Tom Blackburn
#154,937
Most Influential Person Now
Industrial pharmacologist
Tom Blackburn 's AcademicInfluence.com Rankings
Tom Blackburn medical Degrees
Medical
#3604
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Pharmacology
#470
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#527
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Medical
Tom Blackburn 's Degrees
- PhD Pharmacology University of California, San Francisco
- Bachelors Chemistry Stanford University
Why Is Tom Blackburn Influential?
(Suggest an Edit or Addition)According to Wikipedia, Tom Blackburn FBPharmacolS, FRSB is a British industrial pharmacologist. Blackburn studied at both the University of Nottingham and Manchester University, and worked as a senior manager at ICI Pharmaceuticals, Beecham Pharmaceuticals SmithKline Beecham, Synaptic Pharmaceutical Corporation and Helicon Therapeutics.
Tom Blackburn 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist (1997) (513)
- Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist (2002) (400)
- Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS (2000) (381)
- 5-HT2 receptor subtypes: a family re-united? (1995) (364)
- In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties (1996) (250)
- The medical benefit of 5-HT research (2002) (223)
- Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system (1997) (211)
- In vivo properties of SB 200646A, a 5‐HT2C/2B receptor antagonist (1994) (187)
- Trace amine receptors as targets for novel therapeutics: legend, myth and fact. (2003) (167)
- Correction for Swanson et al., Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299 (2005) (165)
- Attenuation of haloperidol‐induced catalepsy by a 5‐HT2C receptor antagonist (1999) (136)
- Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. (1995) (119)
- Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety (1996) (115)
- BW 723C86, a 5-HT2B Receptor Agonist, Causes Hyperphagia and Reduced Grooming in Rats (1997) (108)
- Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT 2C 2B receptor function (1994) (104)
- Activation of 5-HT2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat (1997) (103)
- SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety (2001) (99)
- Further characterization of 5‐hydroxytryptamine receptors (putative 5‐HT2B) in rat stomach fundus longitudinal muscle (1994) (97)
- 5-ht6 receptors as emerging targets for drug discovery. (2000) (97)
- Anxiolytic-like effect of paroxetine in a rat social interaction test (1994) (85)
- Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist (2002) (83)
- 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. (1997) (80)
- Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. (2000) (69)
- Interaction studies and other investigations of the pharmacology of propofol ('Diprivan'). (1985) (61)
- Anxiolytic-like Actions of the Selective 5-HT4 Receptor Antagonists SB 204070A and SB 207266A in Rats (1997) (59)
- 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity. (1995) (57)
- Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents. (1998) (55)
- 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. (2006) (55)
- Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes (1994) (54)
- Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. (1998) (54)
- Depressive disorders: Treatment failures and poor prognosis over the last 50 years (2019) (52)
- In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. (1988) (52)
- BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors (1993) (51)
- Autoradiographic localization of delta opiate receptors in rat and human brain (1988) (50)
- Characterization of a human 5‐hydroxytryptamine3 receptor type A (h5‐HT3R‐AS) subunit stably expressed in HEK 293 cells (1996) (49)
- Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study (2007) (45)
- Profile of SB‐204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures (1997) (43)
- Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety (1994) (41)
- Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists. (1991) (38)
- Effects of viloxazine, its optical isomers and its major metabolites on biogenic amine uptake mechanisms in vitro and in vivo. (1978) (36)
- Effect of acute and chronic administration of the selective 5‐HT2C receptor antagonist SB‐243213 on midbrain dopamine neurons in the rat: An in vivo extracellular single cell study (2002) (36)
- An investigation of the mechanism responsible for fluoxetine-induced hypophagia in rats. (1996) (34)
- Dextromethorphan attenuates post-ischemic hypoperfusion following incomplete global ischemia in the anesthetized rat (1989) (33)
- κ‐Opioid‐induced changes in renal water and electrolyte management and endocrine secretion (1989) (33)
- Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety (1995) (31)
- Suppressant effects of selective 5-HT2 antagonists on rapid eye movement sleep in rats (1989) (30)
- Synthesis and 5-hydroxytryptamine antagonist activity of 2-[[2-(dimethylamino)ethyl]thio]-3-phenylquinoline and its analogues. (1987) (29)
- On the mechanisms of k‐opioid‐induced diuresis (1986) (28)
- An automatic apparatus for recording rotational behaviour in rats with brain lesions. (1973) (26)
- Evidence that the atypical 5‐HT3 receptor ligand, [3H]‐BRL46470, labels additional 5‐HT3 binding sites compared to [3H]‐granisetron (1995) (26)
- Supersensitivity of nigral serotonin receptors and rat rotational behaviour. (1981) (24)
- Unilateral 5,7-dihydroxytryptamine lesions of the dorsal raphe nucleus (DRN) and rat rotational behaviour. (1980) (24)
- Presynaptic GABAB sites in the interpeduncular nucleus (1984) (23)
- Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists. (1996) (22)
- Pharmacology of mammalian GABA-A receptors (1997) (21)
- SB‐205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity (1998) (21)
- 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents. (2000) (21)
- A Query Regarding the Possible Hallucinogenic Effects of Ant Ingestion in South-Central California (1976) (20)
- κ‐Opioid‐receptor agonists modulate the renal excretion of water and electrolytes in anaesthetized rats (1990) (20)
- Additional evidence for functional subclassification of alpha-2 adrenoceptors based on a new selective antagonist, SK&F 104856. (1991) (19)
- BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties (1993) (18)
- 5-hydroxytryptamine antagonistic effects of ICI 169,369, ICI 170,809 and methysergide in human temporal and cerebral arteries. (1991) (17)
- Stereochemical differentiation of anticonvulsant and antihypertensive effects in 4-(fluorobenzoylamino)-benzopyrans (1995) (17)
- GabaB receptor pharmacology - a tribute to Norman Bowery. (2010) (16)
- The acute and chronic administration of the 5‐HT2B/2C receptor antagonist SB‐200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study (2006) (15)
- 1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists. (2000) (15)
- Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist. (1990) (15)
- Evidence that 5-HT agonist-induced rotational behaviour in the rat is mediated via 5-HT1 receptors (2004) (15)
- Isosteric replacement of the indole nucleus by benzothiophene in a series of pyrido[2,3-b]indoles with potential anxiolytic activity (1995) (11)
- Serotonergic agents and Parkinson's disease (2004) (11)
- In vivo studies on delta opioid receptors. (1986) (10)
- ICI 170809, A selective 5-hydroxytryptamine antagonist, inhibits human platelet aggregation in vitro and ex vivo (1990) (10)
- Serotonin (5-Hydroxytryptamine; 5-HT): Receptors (2009) (9)
- GABAB receptor pharmacology - a tribute to Norman Bowery. Preface. (2010) (7)
- Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists. (1999) (7)
- (±)11-Amino-2,6-dimethyl-1,2,3,4-tetrahydro-6H-quinindolin-1-one, a novel gabaA modulator with potential anxiolytic activity (1994) (7)
- Affective Disorders: Depression and Bipolar Disorders (2007) (6)
- The synthesis of pyrazolo[4,3-c]- and imidazo[4,5-c]-Aryl[e]fused pyridines as structural analogues of 4-aminonicotinoates (1995) (6)
- Effects of chronic treatment with two selective 5-HT2 antagonists on sleep in the rat (1993) (4)
- On the mechanisms of kappa-opioid-induced diuresis. (1986) (4)
- A Pharmacological Comparison of the Receptors Mediating Contractile Responses to 5‐Hydroxytryptamine in the Rat Isolated Caudal Artery and Fundic Strip (1993) (4)
- Possible mechanism of 5-methoxy-N, N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats (1982) (4)
- Effects of Lidocaine or Capsaicin on Scratching and Grooming Induced in Mice by Centrally or Peripherally Injected Bombesin a (1988) (3)
- Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5‐HT2C/2B Receptor Antagonists. (1997) (3)
- Effects of amphetamine in major depressive disorder using functional MRI (1995) (2)
- Involvement of a central dopaminergic system in 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in rats with lesions of the dorsal raphé nuclei (2004) (2)
- Neurological drug development: A guide for a start-up biotech (2014) (2)
- Epilepsy, Parkinson’s disease, migraine and brain plasticity — the next paradigm shift? (2003) (2)
- Synthesis and 5-Hydroxytryptamine Antagonist Activity of 2-((2-(Dimethylamino)ethyl)thio)-3-phenylquinoline and Its Analogues. (1988) (1)
- LACK OF CORRELATION BETWEEN IN‐VITRO AND IN‐VIVO ESTIMATES OF 5‐HT2 RECEPTOR ANTAGONISM (1986) (1)
- Differential rotational behaviour after unilateral 5,7-dihydroxytryptamine induced lesions of the dorsal raphé nucleus [proceedings]. (1979) (1)
- The Synthesis of Pyrazolo(4,3‐c)‐ and Imidazo(4,5‐c)‐ Aryl(e)Fused Pyridines as Structural Analogues of 4‐Aminonicotinoates. (1996) (1)
- S.25.05 The 5-HT2C receptor-potential therapeutic opportunities (1997) (1)
- Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation (2022) (1)
- The actions of the selective 5-HT-2c receptor antagonist SB 200646 at 5-HT-2 receptor subtypes in rat caudal artery and stomach fundus (1994) (0)
- P.6.007 Effects of repeated administration of desipramine and fluoxetine on vasopressin-induced grooming in rats (1996) (0)
- In memory of Norman Bowery (1944–2016) (2017) (0)
- Editorial overview: Preface to 'a tribute to professor Norman Bowery'. (2017) (0)
- P-10-26 5-HT2C receptor antagonists and anxiety disorders (1996) (0)
- Current Trends in Drug Discovery – Young Scientists and Tomorrow ’ s Medicines : Highlights from a joint Society for Medicines Research and British Pharmacological Society meeting (2018) (0)
- Analogifremgangsmaade for preparing 2- (aminoalkylthio) -quinolinderivater (1982) (0)
- Characterization of a cloned human 5-hydroxytryptamine-type 3 receptor subunit stably expressed in HEK 293 cells: 30.3 (1995) (0)
- P-2-10 An investigation of the acute effects of sertraline in a rat social interaction test (1995) (0)
- Functional properties of a human recombinant 5-hydroxytryptamine-type 3 receptor expressed in Xenopus laevis oocytes (1995) (0)
- (.+-.)11-Amino-2,6-dimethyl-1,2,3,4-tetrahydro-6H-quinindolin-1-one, a Novel GABAA Modulator with Potential Anxiolytic Activity. (1994) (0)
- INDOLEAMINES AND THERMOREGULATION IN THE RAT (1990) (0)
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