Tom Blundell
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British biochemist
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Why Is Tom Blundell Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Thomas Leon Blundell, is a British biochemist, structural biologist, and science administrator. He was a member of the team of Dorothy Hodgkin that solved in 1969 the first structure of a protein hormone, insulin. Blundell has made contributions to the structural biology of polypeptide hormones, growth factors, receptor activation, signal transduction, and DNA double-strand break repair, subjects important in cancer, tuberculosis, and familial diseases. He has developed software for protein modelling and understanding the effects of mutations on protein function, leading to new approaches to structure-guided and Fragment-based lead discovery. In 1999 he co-founded the oncology company Astex Therapeutics, which has moved ten drugs into clinical trials. Blundell has played central roles in restructuring British research councils and, as President of the UK Science Council, in developing professionalism in the practice of science.
Tom Blundell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comparative protein modelling by satisfaction of spatial restraints. (1993) (12038)
- pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures (2015) (1624)
- FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. (2001) (1304)
- The TRANSPARENT TESTA GLABRA1 Locus, Which Regulates Trichome Differentiation and Anthocyanin Biosynthesis in Arabidopsis, Encodes a WD40 Repeat Protein (1999) (824)
- Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by (1972) (752)
- Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin (2000) (690)
- Insights into DNA recombination from the structure of a RAD51–BRCA2 complex (2002) (680)
- mCSM: predicting the effects of mutations in proteins using graph-based signatures (2013) (666)
- Knowledge-based prediction of protein structures and the design of novel molecules (1987) (636)
- The structure of 2Zn pig insulin crystals at 1.5 A resolution. (1988) (580)
- DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach (2014) (572)
- HOMSTRAD: A database of protein structure alignments for homologous families (1998) (540)
- Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. (1990) (516)
- High-throughput crystallography for lead discovery in drug design (2002) (477)
- New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor (1991) (474)
- Structure of pentameric human serum amyloid P component (1994) (471)
- Structure of Rhombohedral 2 Zinc Insulin Crystals (1969) (454)
- SDM—a server for predicting effects of mutations on protein stability and malfunction (2011) (435)
- Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. (1989) (413)
- JOY: protein sequence-structure representation and analysis (1998) (408)
- X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes (1989) (408)
- The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II (1981) (389)
- Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. (1987) (384)
- Structural evidence for gene duplication in the evolution of the acid proteases (1978) (368)
- Hormone families: pancreatic hormones and homologous growth factors (1980) (358)
- Receptor-binding region of insulin (1976) (357)
- Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations in SDHB and SDHD (2010) (333)
- SDM: a server for predicting effects of mutations on protein stability (2017) (333)
- Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product (1992) (312)
- Environment‐specific amino acid substitution tables: Tertiary templates and prediction of protein folds (1992) (309)
- Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals (1971) (286)
- Keynote review: Structural biology and drug discovery (2005) (283)
- Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures (2017) (279)
- Crystal structure of an Xrcc4–DNA ligase IV complex (2001) (267)
- Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding. (1978) (265)
- pyDock: Electrostatics and desolvation for effective scoring of rigid‐body protein–protein docking (2007) (262)
- Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2 (2003) (261)
- What is 'current opinion' in structural biology? (2011) (259)
- Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. (2004) (259)
- X-ray analysis of the eye lens protein γ-II crystallin at 1·9 Å resolution (1983) (248)
- X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone. (1981) (247)
- Knowledge‐based protein modelling and design (1988) (245)
- PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair (2015) (244)
- X-ray analysis of glucagon and its relationship to receptor binding (1975) (242)
- X-ray analysis of βB2-crystallin and evolution of oligomeric lens proteins (1990) (239)
- The active site of aspartic proteinases (1991) (235)
- Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. (1996) (233)
- Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains. (1987) (232)
- Knowledge-based protein modeling. (1994) (219)
- Crystal Structure of DNA-PKcs Reveals a Large Open-Ring Cradle Comprised of HEAT Repeats (2009) (219)
- Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction (1990) (219)
- Structural basis of hepatocyte growth factor/scatter factor and MET signalling. (2006) (210)
- Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. (1997) (210)
- X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution. (1990) (200)
- Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d (1998) (199)
- Solvent-induced distortions and the curvature of α-helices (1983) (198)
- Conformational flexibility in a small globular hormone: X‐ray analysis of avian pancreatic polypeptide at 0.98‐Å resolution (1983) (193)
- Structural biology in fragment-based drug design. (2010) (192)
- Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling. (1987) (191)
- Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. (2007) (189)
- Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site (1992) (186)
- Three-dimensional structure, specificity and catalytic mechanism of renin (1983) (184)
- Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (2003) (182)
- Structural biology and drug discovery of difficult targets: the limits of ligandability. (2012) (181)
- Fibroblast growth factor receptors: lessons from the genes. (1998) (176)
- Molecular evolution and domain structure of plasminogen‐related growth factors (HGF/SF and HGF1/MSP) (1994) (174)
- A Novel Type of Deubiquitinating Enzyme* (2003) (172)
- Structural and functional constraints in the evolution of protein families (2009) (172)
- Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A. (2001) (170)
- Alignment and searching for common protein folds using a data bank of structural templates. (1993) (163)
- Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. (1993) (162)
- Conformational studies on the pancreatic polypeptide hormone family. (1984) (161)
- Evolution and the tertiary structure of proteins. (1984) (156)
- Atomic Interactions and Profile of Small Molecules Disrupting Protein–Protein Interfaces: the TIMBAL Database (2009) (155)
- Structural biology and drug discovery for protein-protein interactions. (2012) (154)
- BUB1 and BUBR1: multifaceted kinases of the cell cycle (2011) (151)
- Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery (2006) (150)
- Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues (1993) (147)
- DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair (2017) (146)
- Epidermal growth factor binding induces a conformational change in the external domain of its receptor. (1989) (146)
- Ab initio construction of polypeptide fragments: Efficient generation of accurate, representative ensembles (2003) (145)
- Structural biology and drug discovery. (2005) (143)
- From comparisons of protein sequences and structures to protein modelling and design. (1990) (143)
- CODA: A combined algorithm for predicting the structurally variable regions of protein models (2001) (143)
- Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all‐atom statistical potential and the AMBER force field with the Generalized Born solvation model (2003) (139)
- Is the evolution of insulin Darwinian or due to selectively neutral mutation? (1975) (138)
- Does a More Precise Chemical Description of Protein–Ligand Complexes Lead to More Accurate Prediction of Binding Affinity? (2014) (138)
- On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. (1987) (137)
- Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. (2000) (136)
- X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins (1992) (132)
- Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. (2009) (128)
- Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding. (1988) (127)
- The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. (2004) (125)
- Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. (2003) (125)
- Structure-based drug design. (1996) (123)
- Three-Dimensional Atomic Structure of Insulin and Its Relationship to Activity (1972) (123)
- Crystal structure of the pleckstrin homology domain from dynamin (1994) (122)
- Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding (1999) (122)
- Getting knotted: a model for the structure and activation of Spätzle. (1998) (122)
- Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens βγ-crystallins (1985) (120)
- An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure. (1993) (120)
- Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. (2003) (120)
- Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ (2007) (119)
- Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. (2006) (119)
- Phosducin induces a structural change in transducin βγ (1998) (118)
- Energy : the changing climate (2000) (117)
- Using a Fragment-Based Approach To Target Protein–Protein Interactions (2013) (117)
- Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. (2017) (116)
- mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance (2016) (113)
- Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. (1993) (112)
- Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor (2001) (111)
- Is one solution good enough? (2006) (110)
- High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes (1987) (108)
- Protein-protein interactions as druggable targets: recent technological advances. (2013) (108)
- Flexibility and small pockets at protein–protein interfaces: New insights into druggability (2015) (107)
- On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues. (1987) (107)
- High-throughput X-ray crystallography for drug discovery. (2004) (106)
- Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. (2004) (106)
- Protein structure--based drug design. (1994) (106)
- Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases (1992) (106)
- Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer (2012) (104)
- X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin. (1994) (104)
- Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis (2014) (101)
- The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins. (1975) (101)
- The evolution and structure of aminergic G protein-coupled receptors. (1994) (100)
- A novel superfamily of enzymes that catalyze the modification of guanidino groups. (2001) (100)
- Gene and protein structure of a β-crystallin polypeptide in murine lens: relationship of exons and structural motifs (1983) (100)
- Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery (2013) (99)
- Distinguishing structural and functional restraints in evolution in order to identify interaction sites. (2004) (98)
- Exploration of subsite binding specificity of human cathepsin D through kinetics and rule‐based molecular modeling (1993) (98)
- A six-stranded double-psi β barrel is shared by several protein superfamilies (1999) (98)
- Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. (2013) (98)
- Computer graphics modelling of human renin (1984) (97)
- Eye‐lens proteins: The three‐dimensional structure of β‐crystallin predicted from monomeric γ‐crystallin (1981) (97)
- Nerve growth factor revisited. (1993) (97)
- Symmetry, stability, and dynamics of multidomain and multicomponent protein systems. (1996) (96)
- Utilizing graph machine learning within drug discovery and development (2021) (96)
- X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily. (1996) (95)
- Properties of polyproline II, a secondary structure element implicated in protein–protein interactions (2005) (95)
- An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins (1995) (95)
- Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid. (1999) (95)
- Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. (2004) (95)
- Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: A database for modeling and prediction (1996) (94)
- Catching a common fold (1993) (94)
- X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin. (1991) (93)
- Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. (1996) (92)
- Domain flexibility in aspartic proteinases (1992) (91)
- Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing (1998) (91)
- High‐resolution X‐ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme. (1989) (91)
- Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’ in Italy (2015) (91)
- A variable gap penalty function and feature weights for protein 3-D structure comparisons. (1992) (90)
- Snail and spider toxins share a similar tertiary structure and ‘cystine motif’ (1994) (89)
- Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica. (1977) (87)
- CREDO: A Protein–Ligand Interaction Database for Drug Discovery (2009) (85)
- Comparative modelling of barley‐grain aspartic proteinase: A structural rationale for observed hydrolytic specificity (1994) (85)
- Identifying Interactions that Determine Fragment Binding at Protein Hotspots. (2016) (85)
- In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity (2016) (84)
- X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. (1990) (84)
- Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. (1995) (84)
- Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma. (2015) (84)
- Relaxin has conformational homology with insulin (1977) (83)
- Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. (2005) (83)
- Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization. (2002) (83)
- Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery (2012) (82)
- The conformation, flexibility, and dynamics of polypeptide hormones. (1982) (82)
- Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site (2011) (80)
- Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. (2011) (79)
- Predicting the conformational class of short and medium size loops connecting regular secondary structures: application to comparative modelling. (1997) (79)
- Evidence That Heparin Saccharides Promote FGF2 Mitogenesis through Two Distinct Mechanisms* (2008) (78)
- The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis (2016) (78)
- An algorithm for predicting protein–protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements (2006) (76)
- On the Origins of Enzyme Inhibitor Selectivity and Promiscuity: A Case Study of Protein Kinase Binding to Staurosporine (2009) (76)
- TIMBAL v2: update of a database holding small molecules modulating protein–protein interactions (2013) (75)
- Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes (2014) (75)
- X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity. (2000) (74)
- Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency* (2016) (73)
- Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis. (2017) (73)
- Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors. (1983) (72)
- USRCAT: real-time ultrafast shape recognition with pharmacophoric constraints (2012) (72)
- The three‐dimensional structures of mutants of porphobilinogen deaminase: Toward an understanding of the structural basis of acute intermittent porphyria (1994) (71)
- Nerve growth factor: Structure/function relationships (1994) (71)
- High resolution structure of an oligomeric eye lens β-crystallin (1991) (71)
- Cooperative Dimerization of Fibroblast Growth Factor 1 (FGF1) upon a Single Heparin Saccharide May Drive the Formation of 2:2:1 FGF1·FGFR2c·Heparin Ternary Complexes* (2005) (71)
- Mutations in the NHEJ component XRCC4 cause primordial dwarfism. (2015) (70)
- Characterization and modelling of VanT: a novel, membrane‐bound, serine racemase from vancomycin‐resistant Enterococcus gallinarum BM4174 (1999) (70)
- CAMPASS: a database of structurally aligned protein superfamilies. (1998) (70)
- Structure and evolution of insulins: Implications for receptor binding (1992) (68)
- The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules. (1994) (68)
- Molecular anatomy: Phyletic relationships derived from three-dimensional structures of proteins (2005) (68)
- The spatial organization of non-homologous end joining: From bridging to end joining (2014) (67)
- Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. II. Secondary structures. (1994) (67)
- Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. (2010) (67)
- Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis (2018) (66)
- Phylogenetic relationships from three-dimensional protein structures. (1990) (66)
- A Structural Bioinformatics Approach to the Analysis of nonsynonymous Single nucleotide polymorphisms (nsSNPS) and their Relation to Disease (2007) (65)
- Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-Synonymous Single Nucleotide Polymorphisms (2008) (65)
- A novel exhaustive search algorithm for predicting the conformation of polypeptide segments in proteins (2000) (65)
- The binding of heavy metals to proteins (1977) (65)
- The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS. (1990) (64)
- HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families (2001) (64)
- Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. (2006) (64)
- Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry (2017) (64)
- Prothoracicotropic hormone has an insulin‐like tertiary structure (1987) (63)
- X-RAY STRUCTURE OF GELATINASE A CATALYTIC DOMAIN COMPLEXED WITH A HYDROXAMATE INHIBITOR (1999) (63)
- Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database (2011) (63)
- The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet. (1986) (63)
- PDBe-KB: a community-driven resource for structural and functional annotations (2019) (63)
- The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. (2001) (62)
- Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. (2004) (62)
- The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide. (1998) (61)
- Pantothenate biosynthesis in higher plants. (2005) (61)
- Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment. (2006) (61)
- Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains (2012) (61)
- High-resolution crystal structure of the human Notch 1 ankyrin domain. (2005) (60)
- Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. I. Solvent accessibility classes. (1994) (60)
- Structural bioinformatics mutation analysis reveals genotype–phenotype correlations in von Hippel‐Lindau disease and suggests molecular mechanisms of tumorigenesis (2009) (60)
- Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. (1997) (59)
- Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair (2013) (59)
- Structural constraints on protein self‐processing in L‐aspartate‐α‐decarboxylase (2003) (58)
- Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. (2004) (58)
- Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex. (2008) (57)
- Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. (2001) (57)
- Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit. (2006) (57)
- Structural and evolutionary analysis of HLA-D-region products (1984) (57)
- Adaptation of plasminogen activator sequences to known protease structures (1983) (57)
- X-ray analysis and the structure of insulin. (1971) (57)
- An analysis of the periodicity of conserved residues in sequence alignments of G‐protein coupled receptors (1989) (56)
- X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins. (1990) (56)
- Structure of the bovine eye lens protein γB(γII)‐crystallin at 1.47 Å (1993) (56)
- A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus (2014) (56)
- The structure of a synthetic pepsin inhibitor complexed with endothiapepsin. (1987) (56)
- Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1)* (2003) (56)
- Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites (2016) (56)
- Stepwise pathogenic evolution of Mycobacterium abscessus (2021) (56)
- Dissection of DNA double-strand break repair using novel single-molecule forceps (2018) (56)
- Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances. (1993) (56)
- A database of globular protein structural domains: clustering of representative family members into similar folds. (1996) (56)
- Protein-Protein Interactions in Receptor Activation and Intracellular Signalling (2000) (55)
- Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate (2008) (55)
- X‐ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity (1999) (55)
- Structure-based identification and clustering of protein families and superfamilies (1994) (54)
- Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities (2007) (54)
- Genome bioinformatic analysis of nonsynonymous SNPs (2007) (53)
- Chimeric glycosyltransferases for the generation of hybrid glycopeptides. (2009) (52)
- A six-stranded double-psi beta barrel is shared by several protein superfamilies. (1999) (52)
- Dimers of DNA-PK create a stage for DNA double-strand break repair (2020) (52)
- Chemistry, structure and function of insulin and related hormones (1980) (52)
- Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. (2006) (52)
- X-ray studies of aspartic proteinase-statine inhibitor complexes. (1991) (50)
- BIPA: a database for protein-nucleic acid interaction in 3D structures (2009) (50)
- The Crystal Structure of the N-Terminal Region of BUB1 Provides Insight into the Mechanism of BUB1 Recruitment to Kinetochores (2009) (50)
- Structural genomics: an overview. (2000) (49)
- Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations. (2015) (49)
- The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II. (1981) (49)
- Metalloproteinase super–families and drug design (1994) (49)
- A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph (1980) (48)
- The use of amino acid patterns of classified helices and strands in secondary structure prediction. (1996) (48)
- Four-fold structural repeat in the acid proteases. (1979) (46)
- Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist. (2005) (46)
- Crystallographic refinement by knowledge-based exploration of complex energy landscapes. (2005) (46)
- Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites. (2003) (46)
- Cooperative heparin-mediated oligomerization of fibroblast growth factor-1 (FGF1) precedes recruitment of FGFR2 to ternary complexes. (2013) (45)
- Dogfish insulin. Primary structure, conformation and biological properties of an elasmobranchial insulin. (1983) (45)
- Genome3D: exploiting structure to help users understand their sequences (2014) (45)
- Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition* (2010) (45)
- Cell biology: Brief encounters bolster contacts (2006) (45)
- X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus. (1993) (44)
- Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. (2006) (43)
- Browsing the SLoop database of structurally classified loops connecting elements of protein secondary structure (2000) (43)
- Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning (2020) (43)
- Evolutionary and functional relationships between the basic and acidic beta-crystallins. (1988) (43)
- A second front against AIDS (1989) (43)
- Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR* (2005) (43)
- ENERGY: THE CHANGING CLIMATE. 22ND REPORT OF THE ROYAL COMMISSION ON ENVIRONMENTAL POLLUTION (2000) (42)
- X-ray analysis of the eye lens protein gamma-II crystallin at 1.9 A resolution. (1983) (42)
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- The alkanesulfonate-binding protein fromXanthomonas axonopodispv.citri (2009) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 19 (5-fluoroquinazolin-4-ol) (2020) (0)
- X-ray crystallographic studies of human serum amyloid P-component (SAP) (1987) (0)
- Cryo-EM structure of W107R KatG from M. tuberculosis (2021) (0)
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- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution (2017) (0)
- Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India (2019) (0)
- Crystal structure of the human Notch 1 ankyrin domain (2005) (0)
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- The prediction of protein structure and the design of novel ligands for the biotechnological, pharmaceutical and agrochemical industries (2007) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 26 (6-methoxybenzothiazole-2-carboxylic acid) (2020) (0)
- X-ray structural studies of the aspartic proteinases (1984) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 20 (6-Aminobenzothiazole) (2020) (0)
- The determination by X-ray diffraction methods of the crystal and molecular structures of some coordination compounds : a study of the stereochemistry of pentacoordination (1967) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK921295A at 1.61A resolution (2017) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-(cyclopentylmethyl)pyrrolidine-1-carboxamide at 1.77A resolution (2017) (0)
- 3D structure prediction of the kringle 3 domain of human hepatocyte growth factor-scatter factor (HGF-SF) (2006) (0)
- ASPARTIC PROTEINASES: FROM THE FIRST X-RAY PHOTOS OF PEPSIN CRYSTALS TO HUNDREDS OF 3-D STRUCTURES (1997) (0)
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- Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate (2010) (0)
- Structure of Mycobacterium thermoresistibile GlgE in complex with maltose (cocrystallisation with maltose-1-phosphate) at 3.32A resolution (2015) (0)
- Humanised monomeric RadA in complex with 4-methylester indole (2013) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 18 (Isoxazole-5-carbothioamide) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 3 (2-(5-Isoxazolyl) phenol) (2020) (0)
- Cryo-EM structure of DNA-PKcs (State 3) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl-L-homocysteine (2020) (0)
- Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (2020) (0)
- The PAPase Hal2p complexed with magnesium ions and reaction products: AMP and inorganic phosphate (2001) (0)
- 3D structure prediction of the kringle 2 domain of human hepatocyte growth factor-scatter factor (HGF-SF) (2006) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 3 at 1.84A resolution (2016) (0)
- M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 22 (VCC061422) (2019) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 7 (2-Amino-6-fluorobenzothiazole) (2020) (0)
- Cryo-EM structure of DNA-PKcs (State 2) (2020) (0)
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- Protein Engineering and Preliminary X-Ray Analysis of CHY155-165RHI Loop Exchange Mutant (2005) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 6 (2-(1,3-oxazol-5-yl) aniline) (2020) (0)
- Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil (2013) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 5 (Isoxazole-5-carboxamide) (2020) (0)
- Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA FlK - apo wild type FlK (2010) (0)
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- The three-dimensional structure of human serum amyloid P-component defined at 2.0 Å reveals a lectin like fold and calcium mediated ligand binding (1993) (0)
- Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (fragment 1) (2020) (0)
- emical space of the lysine-binding pocket of the fi rst kringle domain of hepatocyte growth factor / scatter factor ( HGF / SF ) yields a new class of inhibitors of HGF / SF-MET binding † (2015) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-((tetrahydrofuran-3-yl)methyl)pyrrolidine-1-carboxamide at 1.93A resolution (2017) (0)
- RadA C-terminal ATPase domain from Pyrococcus furiosus (2012) (0)
- Crystal structure of Mycobacterium tuberculosis ArgF in complex with 5-methyl-4-phenylthiazol-2-amine. (2021) (0)
- Crystal structure of Mycobacterium tuberculosis ArgD with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid. (2021) (0)
- ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME) (1994) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 9 (Adenine) (2020) (0)
- M. thermoresistible IMPDH in complex with IMP and Compound 1 (7759844) (2018) (0)
- Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) (2009) (0)
- BIROn - Birkbeck Institutional Research Online Identification and characterization of genetic determinants of Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis in Southern India. (2021) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid (2009) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-[3-(trifluoromethyl)phenyl]prop-2-enoic acid (2020) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE (2016) (0)
- Crystal structure of Mycobacterium tuberculosis ArgB in complex with 2-phenyl-1H-imidazole (2021) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution (2017) (0)
- Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate (2006) (0)
- Cryo-EM structure of wild-type KatG from M. tuberculosis (2021) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 4 (5-Methoxybenzimidazole) (2020) (0)
- Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs (2022) (0)
- Crystal structure of the Bordetella bronchiseptica enzyme WbmF in complex with NAD+ and UDP (2007) (0)
- Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
- Mycobacterial OtsA structures reveal an allosteric site regulated by 2-oxoglutarate and 2-phosphoglycerate and the mechanism for substrate preference (2019) (0)
- A computer graphics model of frog gamma-crystallin based on the three-dimensional structure of calf gamma-II crystallin. (1986) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide (2020) (0)
- Erratum: Structure of a blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding site (Structure (2011) 19 (1691-1700)) (2011) (0)
- Cryo-EM structure of T275P KatG from M. tuberculosis (2021) (0)
- Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor (2002) (0)
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- Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine (2013) (0)
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- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 2-(4-chloro-3-nitrobenzoyl)benzoic acid (2020) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form (2008) (0)
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- MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE (2016) (0)
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- 3D structure prediction of the Ig2-Ig4 domains of the ectodomain region of the human hepatocyte growth factor-scatter factor receptor, MET (2006) (0)
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- Prarbn engineering of a loop 155-165 in chymosin (1993) (0)
- RadA C-terminal ATPase domain from Pyrococcus furiosus bound to AMPPNP (2012) (0)
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- HR1b domain from PRK1 (2003) (0)
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- Anisotropic refinement of avian (turkey) pancreatic polypeptide at 0. 99 Angstroms resolution. (2004) (0)
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- Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1 (2012) (0)
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- Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID (2013) (0)
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- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 2 at 1.68A resolution (2016) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 2 (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 12 (2-Aminobenzothiazole) (2020) (0)
- Structural and dynamical analysis of integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19 (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 10 (2-Amino-5-bromobenzothiazole) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 16 (2-Amino-3-nitropyridine) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 8 (3-[(2-thienylthio)methyl]benzoic acid) (2020) (0)
- Crystal Structure of Human DNA ligase IV (2013) (0)
- Crystallographic Analysis of Human Serum Amyloid P Component (1988) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 1 (1H-Indole-5-carboxamide) (2020) (0)
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- Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 2-(4-Chloro-3-nitrobenzoyl)benzoic acid (Fragment 6) (2017) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 28 at 1.99A resolution (2016) (0)
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- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution (2016) (0)
- 3D STRUCTURE PREDICTION OF AMINO ACIDS 25 TO 656 OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (MET) RECEPTOR (2004) (0)
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- Biomolecular crystallography: principles, practice and applications to structural biology. By Bernhard Rupp. Pp. 808. Abingdon, New York: Garland Science, Taylor & Francis Group, 2010. Price (hardcover) USD 145.00. ISBN 9780815340812. ISBN-10 0815340818. (2010) (0)
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- Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae (2018) (0)
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- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 5 at 1.57A resolution (2016) (0)
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- Knowledge-Based Protein Modeling and the Design of Novel Molecules (1990) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 4 at 1.87A resolution (2016) (0)
- Crystal structure of Mycobacterium tuberculosis ArgF in complex with (4-nitrophenyl)boronic acid. (2021) (0)
- Crystal structure of human FGF18 (2014) (0)
- Humanised monomeric RadA in complex with 2-amino benzothiazole (2013) (0)
- Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase inMycobacterium leprae (2019) (0)
- Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1 (2013) (0)
- Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with an Alanine insertion at position 26 (2003) (0)
- BIROn - Birkbeck Institutional Research Online impacts of mutations on structures and functions of human cancer-related genes: a preliminary analysis (2021) (0)
- SARS-CoV-2 Omicron subvariant spike N405 unlikely to rapidly deamidate (2023) (0)
- Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 5-methyl-1-phenyl-pyrazole-4-carboxylic acid (Fragment 1) (2017) (0)
- Editorial. (2019) (0)
- 3D structure prediction of the kringle 4 domain of human hepatocyte growth factor-scatter factor (HGF-SF) (2006) (0)
- Peptide Hormones, J.A. Parsons (Ed.). (Macmillan) The British Council, London, New York, San Francisco (1976) (1976) (0)
- Structural characterisation of BtrK decarboxylase from butirosin biosynthesis (2006) (0)
- Comparative Analysis of the Escherichia coli Ketopantoate Hydroxymethyltransferase Crystal Structure Confirms that It Is a Member of the ( (cid:2)(cid:3) ) 8 Phosphoenolpyruvate/Pyruvate Superfamily (2003) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in Apo form (2020) (0)
- Crystal structure of APO form of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus (2017) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with linezolid (2018) (0)
- M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 18 (VCC399134) (2019) (0)
- Comparative Modelling by Restraint-Based Conformational Sampling article openly available. Please share how this access benefits you. Your story matters (2008) (0)
- A base measure of precision for protein stability predictors: structural sensitivity (2021) (0)
- Crystal structure of Mycobacterium tuberculosis ArgC in complex with xanthene-9-carboxylic acid (2021) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 11 (2-Amino-6-chloropurine) (2020) (0)
- Crystallography , structural biology & drug design (2017) (0)
- Crystal structure of human XLF/Cernunnos, a non-homologous end-joining factor (2007) (0)
- ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-135,040 (1994) (0)
- Dimers of DNA-PK create a stage for DNA double-strand break repair (2020) (0)
- Crystal structure of the conserved N-terminal domain of the mitotic checkpoint component BUB1 (2009) (0)
- The PAPase Hal2p complexed with a sodium ion and the reaction product AMP (2001) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3 (2008) (0)
- THE OTHER SIDE OF AChE: ALLOSTERIC SITES AND MODULATORS (2018) (0)
- Serine 25 to Threonine mutation of aspartate decarboxylase (2003) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK1570606A at 1.72A resolution (2017) (0)
- Three-dimensional Structure and Evolution of HIV-1 Protease (1990) (0)
- Ionic control of porin permeability in bacteria (2022) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 1 (0)
- M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718 (2016) (0)
- Sequence Patterns that Characterize Protein Families with a Common Fold (1993) (0)
- Crystal structure of Mycobacterium tuberculosis ArgC apoenzyme (2021) (0)
- From Revolutionary Technologies for Understanding Genes and Proteins to a Focus on New Therapeutics. (2021) (0)
- Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2013) (0)
- ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL) (1994) (0)
- Document S1. Figures S1–S5 and Supplemental Experimental Procedures (2013) (0)
- Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 3-Bromo-1H-indazole-5-carboxylic acid (Fragment 2) (2017) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 27 (Methyl 2-(hydroxymethyl)-6H-thieno[2,3-b]pyrrole-5-carboxylate) (2020) (0)
- Humanised monomeric RadA in complex with napht-2-ol (2013) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 17 (2H-1,3-Benzoxazine-2,4(3H)-dione) (2020) (0)
- 3 – The Analysis of Homologous Tertiary Structures and the Design of Novel Proteins (1973) (0)
- Identification of specificity determining residues in enzymes using environment specific substitution tables (2007) (0)
- Crystal structure of Mycobacterium tuberculosis ArgC in complex with 5-methoxy-1,3-benzoxazole-2-carboxylic acid (2021) (0)
- Polar sidechains bridging to the backbone of proteins have conserved roles in their core (2010) (0)
- Crystal structure of Mycobacterium tuberculosis ArgB in apo form. (2021) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 2 (5-Amino-3-(2-thienyl) pyrazole) (2020) (0)
- Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents (2023) (0)
- The determinants of protein kinase inhibitor selectivity (2011) (0)
- Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis - compound 49e [5-[(3-nitrobenzyl)amino]benzene-1,3-dicarboxylic acid] (2014) (0)
- FUGUE annotated hypothetical proteins derived from microbial genomes (2001) (0)
- From the comparative analysis of proteins to knowledge based modeling (1990) (0)
- Symposium 1: Structure and engineering of proteins: New developments (1990) (0)
- Diffraction data deposition. (1996) (0)
- Multilevel systems biology: Theory and practice (2008) (0)
- Protein Structure, Computer Graphics and Rational Approaches to Molecular Design (1988) (0)
- STRUCTURAL RELATIONSHIPS BETWEEN INSULIN, RELAXIN AND GROWTH FACTORS (1981) (0)
- Structural Biology - Painting the Mechanistic Landscape of Biomolecules. (2022) (0)
- Rule-based approaches to comparative modelling (1993) (0)
- PBMB Commentary on Editorial by Keith Baverstock (2019) (0)
- Genomes , Structural Biology and Drug Discovery : Exploring Chemical and Biological Space (2012) (0)
- The relation of structure to storage and receptor binding of glucagon [proceedings]. (1977) (0)
- KNOWLEDGE-BASED DESIGN OF NOVEL PEPTIDES (1987) (0)
- Archival journal requirements for data deposition. (1996) (0)
- STRUCTURAL EVIDENCE FOR GENE DUPLICATION AND FUSION IN THE EVOLUTION OF PROTEINS (1981) (0)
- Letter to the Editor (1996) (0)
- Archival journal requirements of macromolecular crystallographic data. (1996) (0)
- Structural investigations of peptides and proteins part 2 x ray studies (1972) (0)
- A formal discussion of the archival journal requirements for data deposition. (1996) (0)
- Three-dimensional structure-function relationships in pancreatic hormones (1983) (0)
- Editorial. (2020) (0)
- An Overview. (2022) (0)
- Structural Correlations in Families of Homologous Proteins (1994) (0)
- The Leon Golberg Memorial Lecture. Structural molecular biology and drug discovery. (1995) (0)
- Sequences and topology. (1993) (0)
- Editorial: Seventieth Birthday Celebrations. (2021) (0)
- NCBS SYMPOSIUM ON MOLECULES, MACHINES AND NETWORKS (2003) (0)
- Structural biology - Painting the mechanistic landscape of biomolecules (2022) (0)
- Genomes, protein super-families and drug discovery (1996) (0)
- Crystallography, structural biology and drug design (2017) (0)
- Structural pharmacology and drug discovery: exploring biological and chemical space (2008) (0)
- Predictive Sciences for Drug Discovery (2014) (0)
- Academia industry research networks for the future (1998) (0)
- Plane common sense (2004) (0)
- Dame Louise Napier Johnson. 26 September 1940—25 September 2012 (2022) (0)
- Pantothenate synthase in complex with 2-(5-methoxy-2-(tosylcarbamoyl)-1H-indol-1-yl)acetic acid (2014) (0)
- Crystal structure of Mycobacterium tuberculosis ArgB in complex with methyl 4-hydroxy-3-iodobenzoate (2021) (0)
- Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 4-(2-carboxybenzoyl)-2-nitrobenzoic acid at 1.9A resolution. (2019) (0)
- Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid at 1.8A resolution. (2019) (0)
- Crystal structure of pantothenate synthetase in complex with 2-(5-methoxy-2-(2-nitro-4-(trifluoromethyl)phenylsulfonylcarbamoyl)-1H-indol-1-yl)acetic acid (2014) (0)
- Crystal structure of pantothenate synthetase in complex with 2-(2-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid (2014) (0)
- Crystal structure of pantothenate synthetase in complex with 2-(2-(4-tert-butylphenylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid (2014) (0)
- Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) (2021) (0)
- Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-1-yl)propanoic acid at 1.7A resolution. (2019) (0)
- Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 5-[3-(1H-indol-3-yl)propoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid at 1.8A resolution. (2019) (0)
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