Tom Maniatis

Q: What Schools Are Affiliated With Tom Maniatis

Tom Maniatis is affiliated with the following schools: Harvard University, University of Colorado Boulder, California Institute of Technology, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Case Western Reserve University, Johns Hopkins University, Columbia University, Massachusetts General Hospital

Tom Maniatis's AcademicInfluence.com Rankings

Tom Maniatis

Biology

#341

World Rank

#611

Historical Rank

#200

USA Rank

Molecular Biology

#35

World Rank

#35

Historical Rank

#24

USA Rank

biology Degrees

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Biology

Tom Maniatis's Degrees

PhD Molecular Biology Vanderbilt University
Bachelors Chemistry University of Colorado Boulder

Why Is Tom Maniatis Influential?

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According to Wikipedia, Tom Maniatis , is an American professor of molecular and cellular biology. He is a professor at Columbia University, and serves as the Scientific Director and CEO of the New York Genome Center. Education Maniatis received B.A. and M.S. degrees from the University of Colorado in Boulder, and a PhD in Molecular Biology from Vanderbilt University. He carried out postdoctoral studies at Harvard University and at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England.

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Tom Maniatis's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular Cloning: A Laboratory Manual (2001) (208879)
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. (1984) (5230)
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014) (3622)
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB (1994) (1907)
Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers (1995) (1808)
IKKε and TBK1 are essential components of the IRF3 signaling pathway (2003) (1588)
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020) (1524)
The isolation of structural genes from libraries of eucaryotic DNA (1978) (1362)
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. (1995) (1348)
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007) (1285)
Regulation of inducible and tissue-specific gene expression. (1987) (1264)
Nucleotide sequence of the rightward operator of phage lambda. (1975) (1261)
NF-κB: A lesson in family values (1995) (1257)
An extensive network of coupling among gene expression machines (2002) (1185)
Transformation of mammalian cells with genes from procaryotes and eucaryotes (1979) (1177)
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. (2003) (1136)
Transcriptional activation: A complex puzzle with few easy pieces (1994) (1088)
The structure and evolution of the human β-globin gene family (1980) (1042)
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome (1995) (1038)
Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity (1996) (972)
Detection and localization of single base changes by denaturing gradient gel electrophoresis. (1987) (957)
NF-kappaB signaling pathways in mammalian and insect innate immunity. (2001) (896)
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (2015) (816)
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. (1998) (813)
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing (1993) (782)
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. (1975) (782)
Alternative pre-mRNA splicing and proteome expansion in metazoans (2002) (776)
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function (2015) (775)
Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter (2000) (773)
Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model (2007) (760)
Identification of two distinct regulatory regions adjacent to the human β-interferon gene (1983) (694)
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway (1997) (683)
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus (1990) (682)
The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA (1978) (676)
A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes (1999) (666)
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. (1985) (633)
Structure-based prediction of protein-protein interactions on a genome-wide scale (2012) (595)
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro (1984) (579)
The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene (1992) (568)
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. (1994) (542)
Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro (1984) (536)
Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes (1983) (533)
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. (1995) (530)
Associations between distinct pre‐mRNA splicing components and the cell nucleus. (1991) (529)
Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations (2014) (515)
A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. (2013) (510)
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. (1985) (501)
GAL4 activates transcription in Drosophila (1988) (488)
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts (2003) (475)
Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system (1981) (474)
An Atomic Model of the Interferon-β Enhanceosome (2007) (461)
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing (1987) (451)
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. (1999) (450)
Single Molecule Imaging of Transcription Factor Binding to DNA in Live Mammalian Cells (2013) (432)
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements (1993) (419)
The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions (1980) (416)
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene (2018) (414)
The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction (1989) (408)
A role for exon sequences and splice-site proximity in splice-site selection (1986) (396)
Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway (1996) (390)
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. (1995) (382)
Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei (1983) (379)
PROTOCADHERINS MEDIATE DENDRITIC SELF-AVOIDANCE IN THE MAMMALIAN NERVOUS SYSTEM (2012) (372)
Fine structure genetic analysis of a beta-globin promoter. (1986) (360)
Detection of single base substitutions in total genomic DNA (1985) (359)
The nucleotide sequence of the human β-globin gene (1980) (353)
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA (1993) (348)
Caspase-mediated processing of the Drosophila NF-κB factor Relish (2003) (347)
The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. (1997) (345)
Structure and Function of the Interferon-β Enhanceosome (1998) (337)
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro (1985) (337)
Amplification and characterization of a β-globin gene synthesized in vitro (1976) (337)
Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway (1991) (335)
A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. (2000) (328)
Identification and characterization of a novel repressor of beta-interferon gene expression. (1991) (327)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability (2012) (326)
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. (1996) (324)
Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1 (1995) (322)
NF-kappa B: a lesson in family values. (1995) (320)
IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex (2000) (309)
Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y) (1995) (304)
Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity (2007) (304)
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy (2013) (302)
The primary structure of rabbit β-globin mRNA as determined from cloned DNA (1977) (302)
Intron sequences involved in lariat formation during pre-mRNA splicing (1985) (295)
Molecular cloning and characterization of the human β-like globin gene cluster (1980) (288)
A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing (1982) (282)
Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products (1983) (281)
Multilevel Regulation of Gene Expression by MicroRNAs (2008) (278)
The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene (1982) (277)
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. (1996) (268)
Astrocytes in neurodegenerative disease. (2015) (265)
Immune Activation of NF-κB and JNK Requires Drosophila TAK1* (2003) (265)
Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. (1999) (263)
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. (1999) (262)
Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. (1985) (260)
The molecular genetics of human hemoglobins. (1980) (259)
Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues (1989) (256)
Catalysis by a Multiprotein IκB Kinase Complex (1997) (254)
Selection and Characterization of Pre-mRNA Splicing Enhancers: Identification of Novel SR Protein-Specific Enhancer Sequences (1999) (247)
The human β-interferon gene enhancer is under negative control (1986) (247)
Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. (1990) (247)
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing (2002) (246)
NF-B signaling pathways in mammalian and insect innate immunity (2001) (245)
A general method for saturation mutagenesis of cloned DNA fragments. (1985) (243)
A role for the Drosophila neurogenic genes in mesoderm differentiation (1991) (243)
Enzymatic in vitro synthesis of globin genes (1976) (242)
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. (2012) (241)
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. (1996) (239)
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. (1992) (237)
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. (2007) (236)
Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos. (1990) (233)
An HMG-like protein that can switch a transcriptional activator to a repressor (1994) (232)
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (2001) (230)
Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. (1998) (226)
Rapid reprogramming of globin gene expression in transient heterokaryons (1986) (222)
Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro (1991) (221)
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. (1992) (220)
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. (1997) (219)
Characterisation of deletions which affect the expression of fetal globin genes in man (1979) (217)
Activation of the human beta-interferon gene requires an interferon-inducible factor (1986) (215)
Multiple Distinct Splicing Enhancers in the Protein-Coding Sequences of a Constitutively Spliced Pre-mRNA (1999) (213)
Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells (2013) (213)
CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice (2012) (212)
Single-cell topological RNA-Seq analysis reveals insights into cellular differentiation and development (2017) (212)
Mechanisms of alternative pre-mRNA splicing. (1991) (209)
A striking similarity in the organization of the E-selectin and beta interferon gene promoters (1994) (207)
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line (1983) (207)
A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. (1990) (206)
2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression. (1988) (199)
The structure of a human α-globin pseudogene and its relationship to α-globin gene duplication (1980) (196)
Positive control of pre-mRNA splicing in vitro. (1992) (196)
Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences (1984) (195)
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. (1998) (192)
The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site. (1992) (191)
The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2 (1994) (188)
A systematic analysis of the factors that determine the strength of pre‐mRNA splicing enhancers (1998) (185)
Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter (2000) (185)
Human β-interferon gene expression is regulated by an inducible enhancer element (1985) (184)
Structure and in vitro transcription of human globin genes. (1980) (182)
The role of the mammalian branchpoint sequence in pre-mRNA splicing. (1988) (177)
Structure and function of the interferon-beta enhanceosome. (1998) (177)
Synergistic interactions between two distinct elements of a regulated splicing enhancer. (1995) (176)
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda (1975) (176)
Signal induced degradation of IkBa requires site-specific ubiquitina-tion (1995) (175)
MEKK1 activates both IκB kinase α and IκB kinase β (1998) (174)
cis and trans activation of globin gene transcription in transient assays. (1983) (171)
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice (2009) (171)
Overlapping positive and negative regulatory domains of the human beta-interferon gene. (1988) (166)
Crystal structure and mechanism of activation of TANK-binding kinase 1. (2013) (161)
Common themes in the function of transcription and splicing enhancers. (1997) (159)
A splicing enhancer exhibits both constitutive and regulated activities. (1994) (159)
The role of U2AF35 and U2AF65 in enhancer-dependent splicing. (2001) (158)
Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch*♦ (2007) (158)
The structure of ψ DNA (1974) (154)
Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins (2014) (153)
An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. (1995) (150)
Identification of the rel family members required for virus induction of the human beta interferon gene (1995) (148)
Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. (2002) (145)
The Role of Ubiquitination in Drosophila Innate Immunity* (2005) (144)
Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer (2004) (142)
Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression (2012) (140)
Full length and discrete partial reverse transcripts of globin and chorion mRNAs (1975) (140)
Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer Orientation (2000) (139)
Clustered protocadherins (2013) (137)
Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. (2005) (135)
The regulated expression of β-globin genes introduced into mouse erythroleukemia cells (1983) (133)
Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. (1996) (133)
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS (2017) (132)
Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. (1982) (131)
Transcriptional regulation of globin gene expression in the human erythroid cell line K562. (1983) (129)
The structure and transcription of four linked rabbit β-like globin genes (1979) (129)
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine (1995) (128)
IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. (2000) (127)
A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. (1993) (126)
Human genetic and immunological determinants of critical COVID-19 pneumonia (2022) (126)
Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. (1998) (125)
Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species (2016) (124)
Two different virus‐inducible elements are required for human beta‐interferon gene regulation. (1989) (124)
Detection of factors that interact with the human β-interferon regulatory region in vivo by DNAase I footprinting (1986) (124)
The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. (1992) (123)
Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding (1992) (120)
Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions (2015) (120)
Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes. (1980) (118)
Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (2000) (117)
Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch (1989) (115)
Intricate interplay between astrocytes and motor neurons in ALS (2013) (115)
A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (1992) (113)
Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA (1985) (113)
Action of leucine zippers (1989) (112)
Stochastic Expression of the Interferon-β Gene (2012) (108)
IκB kinase ε (IKKε) regulates the balance between type I and type II interferon responses (2011) (107)
Sequence of a represser-binding site in the DNA of bacteriophage λ (1974) (107)
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. (1989) (106)
Connecting Mitochondria and Innate Immunity (2005) (106)
The organization of repetitive sequences in a cluster of rabbit β-like globin genes (1980) (104)
Purification and visualization of native spliceosomes (1988) (104)
A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. (2001) (103)
The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA. (1991) (102)
A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. (1993) (99)
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly (2017) (98)
Postinduction turnoff of beta-interferon gene expression (1990) (97)
The function of multisite splicing enhancers. (1998) (97)
Identification of long-range regulatory elements in the protocadherin-α gene cluster (2006) (96)
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. (1979) (96)
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function (2015) (94)
Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF. (1995) (94)
Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice (2017) (93)
Multiple repressor binding at the operators in bacteriophage lambda. (1973) (93)
Use of a cDNA library for studies on evolution and developmental expression of the chorion multigene families (1979) (90)
The linkage arrangement of four rabbit β-like globin genes (1979) (90)
Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes. (1989) (90)
NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway* (1998) (90)
An ATF/CREB binding site is required for virus induction of the human interferon beta gene [corrected]. (1992) (89)
The nucleotide sequence of a rabbit β-globin pseudogene (1980) (89)
Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice (2019) (88)
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells (1985) (88)
Endocytic pathway is required for Drosophila Toll innate immune signaling (2010) (86)
A new family of IKK-related kinases may function as IκB kinase kinases (2001) (85)
Regulatory elements required for the activation and repression of the protocadherin-α gene cluster (2011) (85)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (84)
The structure and evolution of the human beta-globin gene family. (1980) (84)
Spliced leader RNAs from lower eukaryotes are trans- spliced in mammalian cells (1992) (84)
Structure and transcription of the Drosophila mulleri alcohol dehydrogenase genes. (1985) (83)
The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. (1994) (83)
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease? (2021) (82)
Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster (2012) (80)
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. (2004) (80)
HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. (1997) (78)
Fractionation of low molecular weight DNA or RNA in polyacrylamide gels containing 98% formamide or 7 M urea. (1980) (77)
The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex. (1993) (75)
A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man. (1992) (73)
Inducible processing of interferon regulatory factor-2 (1992) (73)
Drosophila Adh: A promoter element expands the tissue specificity of an enhancer (1988) (71)
Alternatively spliced transcripts of the sex‐determining gene tra‐2 of Drosophila encode functional proteins of different size. (1990) (71)
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. (2006) (70)
Enhancer-dependent interaction between 5' and 3' splice sites in trans. (1995) (70)
Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. (1985) (67)
Regulatory elements involved in Drosophila Adh gene expression are conserved in divergent species and separate elements mediate expression in different tissues. (1986) (65)
Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins (2016) (65)
Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene. (1988) (64)
Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression (1995) (64)
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA. (1988) (63)
Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. (1992) (63)
Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. (1982) (63)
Recent advances in the development of methods for detecting single-base substitutions associated with human genetic diseases. (1986) (63)
Expression cloning of the murine interferon gamma receptor cDNA. (1989) (62)
Visualization of clustered protocadherin neuronal self-recognition complexes (2019) (61)
Catalysis by a multiprotein IkappaB kinase complex. (1997) (61)
Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret (2010) (60)
A new mutation in IVS-1 of the human beta globin gene causing beta thalassemia due to abnormal splicing. (1987) (60)
Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment (2021) (59)
Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. (1999) (59)
The role of specific enhancer-promoter interactions in the Drosophila Adh promoter switch. (1989) (58)
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. (1978) (56)
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice (2020) (55)
Promoters are in the operators in phage lambda (1974) (54)
Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. (2018) (53)
Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA. (1987) (53)
SR proteins are ‘locators’ of the RNA splicing machinery (1999) (52)
Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains. (1990) (51)
Systems-level analyses identify extensive coupling among gene expression machines (2006) (50)
Identification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene. (1990) (50)
Structure of the λ Operators (1973) (49)
Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. (1997) (49)
Cardiac glycosides are potent inhibitors of interferon-β gene expression (2010) (48)
Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers (1992) (47)
Signal-induced site-specific phosphorylation targets IKB x to the ubiquitin-proteasome pathway (2012) (46)
Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. (2005) (45)
Molecular and Functional Interaction between Protocadherin-γC5 and GABAA Receptors (2012) (45)
Protocadherin cis-dimer architecture and recognition unit diversity (2017) (45)
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. (1980) (43)
A new family of IKK-related kinases may function as I kappa B kinase kinases. (2001) (43)
Histone and DNA Modifications as Regulators of Neuronal Development and Function. (2016) (43)
44 Positive and Negative Control of Human Interferon-β Gene Expression (1992) (42)
Amplification and characterization of a beta-globin gene synthesized in vitro. (1976) (42)
γ-Protocadherin structural diversity and functional implications (2016) (40)
Studying severe long COVID to understand post-infectious disorders beyond COVID-19 (2022) (40)
Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. (1996) (39)
Molecular cloning and characterization of the human beta-like globin gene cluster. (1980) (37)
Eucaryotic Gene Regulation (1980) (37)
ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data (2011) (36)
Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells (2014) (36)
The nucleotide sequence of the human beta-globin gene. (1980) (34)
The generation of a protocadherin cell-surface recognition code for neural circuit assembly (2019) (34)
Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus Infections (2011) (33)
High-level expression of a cloned HLA heavy chain gene introduced into mouse cells on a bovine papillomavirus vector (1984) (33)
IKKε is part of a novel PMA-inducible IkappaB kinase complex. Molecular Cell 5:513-522 (2000) (33)
ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy (2021) (32)
Control elements in the DNA of bacteriophage lambda. (1974) (31)
Proteolytic processing of protocadherin proteins requires endocytosis (2010) (30)
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. (1984) (29)
Structural origins of clustered protocadherin-mediated neuronal barcoding. (2017) (29)
The organization, structure, and in vitro transcription of Alu family RNA polymerase III transcription units in the human alpha-like globin gene cluster: precipitation of in vitro transcripts by lupus anti-La antibodies. (1982) (29)
The organization of repetitive sequences in mammalian globin gene clusters. (1981) (28)
Mechanisms of human beta-interferon gene regulation. (1986) (27)
Control of Gene Expression (1974) (27)
Human beta-interferon gene expression is regulated by an inducible enhancer element. (1985) (27)
Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity (2019) (26)
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. (1980) (26)
A dimer-specific function of the transcription factor NFATp (2008) (26)
Regulation of Drosophila Adh promoter switching by an initiator‐targeted repression mechanism (1998) (26)
MEKK1 activates both I k B kinase a and I k B kinase b (1998) (26)
Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster (2012) (24)
Prevalent Presence of Periodic Actin-spectrin-based Membrane Skeleton in a Broad Range of Neuronal Cell Types and Animal Species (2016) (24)
Selection of sequences recognized by a DNA binding protein using a preparative southwestern blot. (1991) (22)
Greek (Aγ) variant of hereditary persistence of fetal haemoglobin: globin gene organization and studies of expression of fetal haemoglobins in clonal erythroid cultures (1982) (22)
The human beta-interferon gene enhancer is under negative control. (1986) (21)
Role of the Ubiquitin—Proteasome Pathway in NF-κB Activation (1998) (21)
Gene regulation. Action of leucine zippers. (1989) (20)
Axonal transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations (2014) (20)
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. (1977) (19)
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs (2022) (18)
A DNA operator-repressor system. (1976) (18)
Solid phase chemistry to covalently and reversibly capture thiolated RNA (2018) (18)
Coordinate viral induction of tumor necrosis factor a and interferon f8 in human B cells and monocytes (17)
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. (1974) (17)
In vitro assembly of enhancer complexes. (1996) (16)
Regulated expression of human alpha- and beta-globin genes in transient heterokaryons (1991) (16)
Clustered gamma-protocadherins regulate cortical interneuron programmed cell death (2020) (16)
Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons (2018) (16)
A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS (2019) (14)
Plasmid vectors for the rapid isolation and transcriptional analysis of human beta-globin gene alleles. (1983) (14)
Gene modification: Targeting in mammalian cells (1985) (13)
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases. (2020) (13)
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children (2022) (12)
Studies on the structure of genes expressed during development. (1978) (12)
The structure of psi DNA. (1974) (11)
ExpressionPlot : A web-based framework for analysis of RNA-Seq and microarray gene expression data (2010) (11)
The Function of Multisite Splicing Enhancers enhancers are thought to function by recruitingthe splic - (1998) (11)
Parallel pathways of virus recognition. (2006) (11)
Structural and functional defects in beta-thalassemia. (1983) (11)
ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy (2021) (10)
An ATF/CREB binding site protein is required for virus induction of the human interferon β gene (1992) (10)
Gene expression and differentiation. (1993) (10)
adhesion molecule 1 . transcriptional activator of vascular cell cooperates with NF-kappa B as a Endothelial interferon regulatory factor 1 (1995) (10)
Role of adenine functional groups in the recognition of the 3'-splice-site AG during the second step of pre-mRNA splicing. (2000) (9)
A Prion-like Trigger of Antiviral Signaling (2011) (9)
THE DEVELOPMENTALLY REGULATED MULTIGENE FAMILIES ENCODING CHORION PROTEINS IN SILKMOTHS (1978) (9)
The linkage arrangement of four rabbit beta-like globin genes. (1979) (7)
Beta-thalassemia: analysis of mRNA precursors of a mutant human globin gene with defective splicing using peripheral blood nucleated red blood cells. (1986) (6)
Structure of the lambda operators. (1973) (6)
Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale (2013) (6)
Activation of Nuclear Factor-κB (2001) (6)
Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells” (2013) (6)
Postinduction Turnoff ofBeta-Interferon GeneExpression (1990) (5)
The structure and transcription of four linked rabbit beta-like globin genes. (1979) (5)
Intramitochondrial localization of the nicotinamide adenien dinucleotide- and nicotinamide adenine dinucleotide phosphate-dependent zylitol dehydrogenases. (1968) (5)
TRANSFORMATION OF MAMMALIAN CELLS WITH PROKARYOTIC AND EUKARYOTIC GENES (1979) (5)
Targeting in mammalian cells. (1985) (5)
Tissue-specific DNA methylation in a cluster of rabbit (-like globin genes ( gene mapping / molecular cloning / gene expression ) (5)
Amplification and characterization of eukaryotic structural genes. (1978) (4)
11 – Recombinant DNA Procedures in the Study of Eukaryotic Genes (1980) (4)
Regulated expression of an extrachromosomal human p-interferon gene in mouse cells ( interferon induction / double-stranded RNA / bovine papilloma virus vector / DNA-mediated gene transfer / transcript mapping ) (4)
Antisense lncRNA transcription drives stochastic Protocadherin α promoter choice (2018) (4)
IN VITRO SYNTHESIS AND MOLECULAR CLONING OF EUKARYOTIC STRUCTURAL GENES (1976) (4)
The nucleotide sequence of a rabbit beta-globin pseudogene. (1980) (4)
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (2023) (3)
Regional Collapsing of Rare Variation Implicates Specific Genic Regions in ALS (2018) (3)
On the road from classical to modern molecular biology (2012) (2)
Mechanisms of human β-globin pre-mRNA splicing (1985) (2)
AN APPROACH TO THE STUDY OF DEVELOPMENTALLY REGULATED GENES (1977) (2)
Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study (2021) (2)
γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons (2022) (2)
Stage-specific reprogramming of globin gene expression. (1987) (1)
Regulated Expression of Human ot- and 1-Globin Genes in Transient Heterokaryons (2004) (1)
6 – Exon Sequences and Splice Site Proximity Play a Role in Splice Site Selection (1987) (1)
Author response: γ-Protocadherin structural diversity and functional implications (2016) (1)
Ultra-Rare Exonic Variants Identified in a Founder Population Implicate Cadherins and Protocadherins in Schizophrenia (2021) (1)
Clustered γ-Protocadherins Regulate Cortical Interneuron Programmed Cell Death (2020) (1)
Postinduction repression of the , 3-interferon gene is mediated through two positive regulatory domains ( positive regulatory domain I / positive regulatory domain il / virus induction / interferon induction / repressor ) (1)
Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic epidemiological study (2021) (1)
Genetic Engineering (1990) (1)
Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons (2018) (1)
Unpicking neurodegeneration in a dish with human pluripotent stem cells (2013) (1)
Regulated expression of cloned globin genes introduced into mouse erythroleukemia cells. (1983) (1)
The Neuroscientist comments (2000) (1)
Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey (2022) (1)
The Human P-Interferon Gene Enhancer nder Negative Control (1986) (0)
Gene expression and differentiation. (1992) (0)
Visualization of clustered protocadherin neuronal self-recognition complexes (2019) (0)
Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells v1 (0)
Author response: Clustered gamma-protocadherins regulate cortical interneuron programmed cell death (2020) (0)
Molecular Cloning and Characterization of a Developmentally Regulated Multigene Family (1976) (0)
Edinburgh Explorer Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells (2018) (0)
Editorial Board (1995) (0)
THE LINKAGE ARRANGEMENT OF MAMMALIAN β-LIKE GLOBIN GENES (1979) (0)
Genetic Engineering (1983) (0)
Introduction and expression of beta-globin genes in murine erythroleukemic cells. (1983) (0)
Genetic Engineering: Principles and Methods (1985) (0)
Protocadherin Gene Clusters Comparative DNA Sequence Analysis of Mouse and Human (2001) (0)
Complex Intracellular Mechanisms of TBK1 Kinase Activation Revealed by a Specific Small Molecule Inhibitor (2022) (0)
Genetic Engineering (1984) (0)
A geneencoding theheavychain ofan HLA humanhistocompatibility (1984) (0)
Genetic Engineering (1988) (0)
Sequences and factors involved in pre-mRNA splicing in vitro (1985) (0)
Tom Maniatis Enhancer Sequences Identification of Novel SR Protein-Specific Pre-mRNA Splicing Enhancers : Selection and Characterization of (1999) (0)
Regulation of NF-kappa-B's effect through the proteasome (1995) (0)
Regulation of NF-KB activity by proteasomes (1995) (0)
"Bound" to Work: The Free Hormone Hypothesis Revisited (2005) (0)
Identification of an inducible factor that binds to a positive regulatory element of the human a 8-interferon gene [ transcription factors / DNA-protein interactions / virus and poly ( I ) poly ( C ) induction / protein modification ] (0)
I. General Papers Ii. Applications 1. Mrna Target A. Dna Probe A. Rpl (0)
Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells. (1984) (0)
Correct Developmental and Tissue Specific Expression of a Cloned Alcohol Dehydrogenase Gene Introduced into the Drosophila Germ Line by P Element Transformation (1984) (0)
Regulation of NF-kappa B activity through proteasome (1995) (0)
Clustered protocadherin molecular assembly and implications for neuronal self-avoidance (2017) (0)
Nucleotile Sequence oftheRightward Operator ofPhagex (Xrepressor/DNA sequencing/restriction enzymes/gene regulation/DNA-protein interaction) (1975) (0)
Editorial Board (1995) (0)
Regulation proteasome activity nf-kappa-B. (1995) (0)
Rearrangement of upstream regulatory elements leads to ectopic expression of the Drosophila mulleri Adh-2 gene. (1992) (0)
Editorial Board (1995) (0)
Characterization of Linked Human Globin Genes by Molecular Cloning Procedures (1981) (0)
Post-vaccination SARS-COV-2 among healthcare workers in New Jersey : a genomic 1 epidemiological study 2 3 4 (2021) (0)
NMR Structure of IBiD, A Domain of CBP/p300 (2001) (0)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (0)
A Striking Similarity intheOrganization oftheE-Selectin andBetaInterferon GenePromoters (1994) (0)
Human Spinal Cord Nuclei Isolation v1 (protocols.io.9yhh7t6) (2019) (0)
PNAS Plus Significance Statements (2015) (0)
Genetic Engineering (1989) (0)
Genetic Engineering (1991) (0)
Common themes in the function of transcription enhancers (2001) (0)
Harold Weintraub (1945–1995) (1995) (0)
Abstract C037: Polyethnic-1000: A New York-based initiative to advance cancer genomics through recruitment of diverse racial & ethnic populations (2023) (0)

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