Tomas Ganz
American physician
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Philosophy
Tomas Ganz's Degrees
- Bachelors Biochemistry University of California, Berkeley
Why Is Tomas Ganz Influential?
(Suggest an Edit or Addition)According to Wikipedia, Tomas Ganz is an American physician-scientist who has made important contributions to innate immunology and the pathophysiology of iron regulation. He was born in Prague, Czechoslovakia in 1948, and immigrated to the United States in 1966. He studied physics at University of California, Los Angeles and obtained a Ph.D. in Applied Physics from the California Institute of Technology in 1976 and an M.D. from the University of California, Los Angeles in 1978. In 1983, after receiving training in pulmonology and internal medicine, he became a faculty member at UCLA in the department of medicine. Later he received a joint appointment in the graduate program in cellular and molecular pathology. He has studied the role of small peptide mediators in human physiology and disease. In 2005, he received the Marcel Simon Prize of the International Bioiron Society for the discovery of the iron-regulatory hormone hepcidin and in 2014 was honored by the E. Donnall Thomas Award from the American Society of Hematology "... for his groundbreaking research in iron homeostasis, including the discovery of the iron-regulatory hormone hepcidin and investigation of its roles in iron metabolism". He is also credited with the discovery erythroferrone, the hormone produced by red cell precursors in the marrow to maintain the iron supply for the production of red cells. He lists more than 400 publications with a Google H-index of 166 . He is a Distinguished Professor of Medicine and Pathology at the David Geffen School of Medicine at UCLA.
Tomas Ganz's Published Works
Published Works
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization (2004) (3422)
- Defensins: antimicrobial peptides of innate immunity (2003) (2517)
- IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004) (2422)
- Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver* (2001) (2078)
- Endogenous antimicrobial peptides and skin infections in atopic dermatitis. (2002) (1839)
- Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. (2003) (1452)
- Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. (2003) (1402)
- Defensins. Natural peptide antibiotics of human neutrophils. (1985) (1391)
- An antimicrobial activity of cytolytic T cells mediated by granulysin. (1998) (1083)
- Hepcidin and iron homeostasis. (2012) (1013)
- Defensins: antimicrobial and cytotoxic peptides of mammalian cells. (1993) (1007)
- Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis (2004) (958)
- Reduced Paneth cell α-defensins in ileal Crohn's disease (2005) (870)
- IDENTIFICATION OF ERYTHROFERRONE AS AN ERYTHROID REGULATOR OF IRON METABOLISM (2014) (864)
- Hepcidin and iron regulation, 10 years later. (2011) (861)
- High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin (2007) (811)
- KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease (2012) (793)
- Systemic iron homeostasis. (2013) (782)
- Kidney disease: Improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease (2012) (757)
- Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. (1998) (754)
- Antimicrobial peptides in mammalian and insect host defence. (1999) (723)
- Regulation of iron metabolism by hepcidin. (2006) (713)
- Immunoassay for human serum hepcidin. (2008) (693)
- Defensins of vertebrate animals. (2002) (693)
- Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. (1999) (684)
- Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. (1989) (666)
- Anemia of inflammation. (2014) (605)
- Reduced Paneth cell alpha-defensins in ileal Crohn's disease. (2005) (584)
- Production of β-defensins by human airway epithelia (1998) (559)
- Iron homeostasis in host defence and inflammation (2015) (535)
- Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. (2005) (531)
- Monocyte-chemotactic activity of defensins from human neutrophils. (1989) (513)
- Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. (1990) (511)
- The Role of Hepcidin in Iron Metabolism (2009) (507)
- A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. (1990) (506)
- Primary structures of three human neutrophil defensins. (1985) (500)
- Suppression of hepcidin during anemia requires erythropoietic activity. (2006) (493)
- Hepcidin and disorders of iron metabolism. (2011) (444)
- Hepcidin in iron overload disorders. (2005) (439)
- The molecular mechanism of hepcidin-mediated ferroportin down-regulation. (2007) (427)
- Paneth cell trypsin is the processing enzyme for human defensin-5 (2002) (424)
- The multifaceted Paneth cell (2002) (410)
- Hepcidin is decreased in TFR2 hemochromatosis. (2005) (407)
- Antimicrobial peptides of vertebrates. (1998) (405)
- Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity1 (2001) (405)
- Ironing out Ferroportin. (2015) (398)
- Detection, evaluation, and management of iron-restricted erythropoiesis. (2010) (386)
- Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. (2005) (368)
- Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. (2009) (363)
- Anemia of inflammation. (2019) (362)
- Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. (2002) (354)
- Iron imports. IV. Hepcidin and regulation of body iron metabolism. (2006) (349)
- Neutrophils and host defense. (1988) (347)
- Liver iron concentrations and urinary hepcidin in beta-thalassemia. (2007) (342)
- Cathelicidins: a family of endogenous antimicrobial peptides (2002) (337)
- Defensins: Endogenous antibiotic peptides of animal cells (1991) (336)
- Defensins and Host Defense (1999) (334)
- Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors1 (2003) (334)
- Defensins and other endogenous peptide antibiotics of vertebrates (1995) (331)
- Molecular control of iron transport. (2007) (329)
- Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. (2005) (327)
- Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. (2009) (324)
- Iron sequestration and anemia of inflammation. (2009) (304)
- Innate Antimicrobial Activity of Nasal Secretions (1999) (301)
- The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis* 210 (2002) (283)
- The Role of Antimicrobial Peptides in Innate Immunity1 (2003) (279)
- Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. (1998) (279)
- Activation of Toll-Like Receptor 2 on Human Tracheobronchial Epithelial Cells Induces the Antimicrobial Peptide Human β Defensin-2 1 (2003) (275)
- The N‐terminus of Hepcidin is Essential for Its Interaction with Ferroportin: Structure‐Function Study (2005) (275)
- Production of beta-defensins by human airway epithelia. (1998) (274)
- Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. (1989) (274)
- Iron in innate immunity: starve the invaders. (2009) (273)
- Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. (2007) (266)
- Localized antimicrobial peptide expression in human gingiva. (2001) (261)
- Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. (2012) (261)
- Hepcidin and its role in regulating systemic iron metabolism. (2006) (260)
- Antimicrobial components of vaginal fluid. (2002) (256)
- In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. (1986) (252)
- Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. (2008) (246)
- Discovery of new human β-defensins using a genomics-based approach (2001) (241)
- Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. (1988) (238)
- Broad-spectrum antimicrobial activity of human intestinal defensin 5 (1997) (237)
- Antimicrobial polypeptides in host defense of the respiratory tract. (2002) (235)
- Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. (2015) (235)
- Differential Regulation of β-Defensin Expression in Human Skin by Microbial Stimuli1 (2005) (231)
- Regulation of iron acquisition and iron distribution in mammals. (2006) (229)
- Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice (2011) (226)
- Macrophages and Systemic Iron Homeostasis (2012) (225)
- Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. (2011) (224)
- Defensin-rich dense granules of human neutrophils. (1987) (224)
- Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. (1993) (224)
- Antimicrobial peptides of phagocytes and epithelia. (1997) (220)
- Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. (2005) (219)
- Granulysin, a T Cell Product, Kills Bacteria by Altering Membrane Permeability1 (2000) (217)
- Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans1 (2003) (217)
- Antimicrobial factors in the cervical mucus plug. (2002) (212)
- The molecular basis of ferroportin-linked hemochromatosis. (2005) (210)
- The human β-defensin-1 and α-defensins are encoded by adjacent genes : Two peptide families with differing disulfide topology share a common ancestry (1997) (208)
- Proinflammatory state, hepcidin, and anemia in older persons. (2010) (207)
- Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. (2010) (207)
- Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. (2008) (204)
- Antimicrobial polypeptides of human neutrophils. (1990) (204)
- Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. (1988) (203)
- Antibiotic peptides from higher eukaryotes: biology and applications. (1999) (201)
- Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. (2007) (199)
- Defensins (1990) (196)
- Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. (2005) (196)
- Localization of human intestinal defensin 5 in Paneth cell granules (1997) (195)
- Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. (2012) (195)
- Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization (2008) (195)
- Defensins: a family of antimicrobial and cytotoxic peptides. (1994) (195)
- Posttranslational processing of defensins in immature human myeloid cells. (1992) (194)
- Hepcidin in iron metabolism (2004) (193)
- Cationic Polypeptides Are Required for Antibacterial Activity of Human Airway Fluid1 (2002) (193)
- Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. (2005) (192)
- Determinants of Staphylococcusaureus Nasal Carriage (2001) (191)
- Cellular iron: ferroportin is the only way out. (2005) (186)
- Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. (1999) (186)
- By IL-1 Signaling, Monocyte-Derived Cells Dramatically Enhance the Epidermal Antimicrobial Response to Lipopolysaccharide1 (2003) (186)
- Human defensin gene copy number polymorphisms: Comprehensive analysis of independent variation in α- and β-defensin regions at 8p22–p23 (2005) (184)
- Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. (1988) (184)
- In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. (1986) (184)
- Defensins and innate host defence of the gastrointestinal tract (1999) (182)
- Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. (2012) (181)
- Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. (2018) (180)
- Defensins: antimicrobial peptides of vertebrates. (2004) (178)
- Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. (2015) (177)
- Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. (1990) (171)
- Antimicrobial peptides of leukocytes (1997) (168)
- The molecular basis of hepcidin-resistant hereditary hemochromatosis. (2009) (165)
- Reduced serum hepcidin levels in patients with chronic hepatitis C. (2009) (164)
- In human epidermis, β-defensin 2 is packaged in lamellar bodies (2003) (163)
- Urinary hepcidin in congenital chronic anemias (2007) (162)
- Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes (1985) (161)
- The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study (2015) (159)
- Hepcidin and Host Defense against Infectious Diseases (2015) (159)
- Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae (2004) (158)
- Activity of rabbit leukocyte peptides against Candida albicans (1985) (156)
- Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens1 (2006) (153)
- Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. (2007) (153)
- Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins (1997) (153)
- Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism. (2006) (152)
- Antimicrobial polypeptides (2004) (150)
- Iron and infection (2017) (150)
- The hepcidin-binding site on ferroportin is evolutionarily conserved. (2008) (149)
- Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes (1987) (148)
- TGF-α Regulates TLR Expression and Function on Epidermal Keratinocytes1 (2005) (148)
- Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. (2006) (146)
- Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. (1988) (144)
- Hepcidin and iron-loading anemias. (2006) (144)
- Isolation and characterization of human defensin cDNA clones. (1988) (144)
- Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. (2001) (143)
- Neutrophil defensins: purification, characterization, and antimicrobial testing. (1994) (141)
- The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. (2011) (138)
- Iron-regulatory protein hepcidin is increased in female athletes after a marathon (2005) (137)
- Reversible Deficiency of Antimicrobial Polypeptides in Bacterial Vaginosis (2006) (137)
- Human neutrophil defensin and serpins form complexes and inactivate each other. (1995) (135)
- Discovery of new human beta-defensins using a genomics-based approach. (2001) (133)
- Purification and characterization of defensins from cystic fibrosis sputum (1997) (131)
- Anemia of Inflammation. (2019) (131)
- Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. (2011) (131)
- In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. (2010) (129)
- Cationic defensins arise from charge‐neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity? (1992) (128)
- Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. (2016) (128)
- Regulation of Human β-Defensins by Gastric Epithelial Cells in Response to Infection with Helicobacter pylori or Stimulation with Interleukin-1 (2000) (128)
- Intramolecular inhibition of human defensin HNP-1 by its propiece. (1996) (128)
- Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. (2012) (127)
- Iron metabolism: interactions with normal and disordered erythropoiesis. (2012) (126)
- Iron homeostasis: An anthropocentric perspective (2017) (124)
- Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. (2005) (122)
- Erythroferrone contributes to recovery from anemia of inflammation. (2014) (121)
- Defensins and other antimicrobial peptides: a historical perspective and an update. (2005) (120)
- Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare (1992) (119)
- Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. (2016) (118)
- Iron homeostasis: fitting the puzzle pieces together. (2008) (116)
- Endogenous Vertebrate Antibiotics (1996) (116)
- Porcine Epithelial β-Defensin 1 Is Expressed in the Dorsal Tongue at Antimicrobial Concentrations (1999) (113)
- The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes (1989) (112)
- An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy. (2001) (112)
- Disordered hepcidin-ferroportin signaling promotes breast cancer growth. (2014) (110)
- Molecular pathogenesis of anemia of chronic disease (2006) (110)
- Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. (2008) (107)
- A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. (2014) (107)
- Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. (2008) (107)
- Purification and antimicrobial properties of three defensins from rat neutrophils (1989) (107)
- A 450-kb contig of defensin genes on human chromosome 8p23. (1999) (105)
- Involvement of Hepcidin in the Anemia of Multiple Myeloma (2008) (105)
- The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. (2001) (105)
- Distinct Defensin Profiles in Neisseria gonorrhoeae and Chlamydia trachomatis Urethritis Reveal Novel Epithelial Cell-Neutrophil Interactions (2005) (105)
- Detection of β-defensins secreted by human oral epithelial cells (2001) (103)
- Macrophages and Iron Metabolism. (2016) (103)
- Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. (2016) (103)
- Inhibition of hepcidin transcription by growth factors (2012) (102)
- Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin (2014) (102)
- Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. (2008) (101)
- Hepcidin Induction by Pathogens and Pathogen-Derived Molecules Is Strongly Dependent on Interleukin-6 (2013) (99)
- Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity (1985) (99)
- The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. (1997) (98)
- Erythropoietic regulators of iron metabolism. (2019) (98)
- Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. (1997) (98)
- Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan. (2003) (97)
- The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment†,‡ (2001) (97)
- Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. (2010) (97)
- Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. (2017) (96)
- Calcitermin, a novel antimicrobial peptide isolated from human airway secretions (2001) (96)
- Immunoassay for human serum erythroferrone. (2017) (95)
- Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis (2021) (95)
- Epithelia: Not just physical barriers (2002) (93)
- Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. (2014) (92)
- Activated α2-Macroglobulin Is a Principal Defensin-binding Protein (1991) (92)
- Cancer-Specific Loss of β-Defensin 1 in Renal and Prostatic Carcinomas (2003) (91)
- The structure of porcine protegrin genes (1995) (91)
- Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors (2011) (90)
- Protegrins: new antibiotics of mammalian origin (2000) (89)
- Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. (2008) (88)
- Immunohistochemical localization of defensin in human coronary vessels. (1997) (88)
- Molecular cloning and tissue expression of porcine β‐defensin‐1 (1998) (87)
- The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting. (1995) (86)
- Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow (2017) (85)
- Effects of maternal iron status on placental and fetal iron homeostasis. (2019) (85)
- Structures of genes for two cathelin‐associated antimicrobial peptides: prophenin‐2 and PR‐39 (1995) (84)
- Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. (1997) (83)
- Defensin Modulates Tissue-type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells* (1996) (83)
- In human epidermis, beta-defensin 2 is packaged in lamellar bodies. (2003) (82)
- TGF-alpha regulates TLR expression and function on epidermal keratinocytes. (2005) (82)
- Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. (2009) (81)
- Assignment of defensin gene(s) to human chromosome 8p23. (1989) (81)
- Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. (2004) (80)
- Defensin promotes the binding of lipoprotein(a) to vascular matrix. (1999) (79)
- Human beta defensin is absent in burn blister fluid. (2000) (79)
- Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. (2010) (79)
- Paneth cells—guardians of the gut cell hatchery (2000) (78)
- The structure of neutrophil defensin genes (1993) (78)
- Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. (1988) (78)
- Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines. (1993) (78)
- Isolation of human intestinal defensins from ileal neobladder urine (1998) (78)
- Activation of a Src-dependent Raf–MEK1/2–ERK signaling pathway is required for IL-1α-induced upregulation of β-defensin 2 in human middle ear epithelial cells (2002) (77)
- In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins (1990) (77)
- Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. (2009) (76)
- Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins. (1988) (75)
- The Role of Protegrins and Other Elastase-Activated Polypeptides in the Bactericidal Properties of Porcine Inflammatory Fluids (1998) (74)
- The structure of the rabbit macrophage defensin genes and their organ-specific expression. (1989) (73)
- High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists (2013) (71)
- A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo. (2002) (71)
- A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis (2011) (71)
- Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. (2018) (70)
- Faculty Opinions recommendation of Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. (2003) (70)
- Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. (2003) (70)
- An enzyme immunoassay for human defensins. (1991) (69)
- Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides. (1996) (68)
- The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. (2002) (67)
- β-Defensin Expression in Human Mammary Gland Epithelia (2000) (66)
- Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. (2017) (65)
- The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. (2000) (65)
- Hepcidin is a key mediator of anemia of inflammation in Crohn's disease. (2013) (63)
- Versatile Defensins (2002) (62)
- Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. (2008) (62)
- Human antimicrobial peptides: analysis and application. (2000) (61)
- Dysregulated iron metabolism in polycythemia vera: etiology and consequences (2018) (60)
- Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? (2018) (60)
- Identification of defensin binding to C1 complement (1994) (60)
- Defensins in the urinary tract and other tissues. (2001) (59)
- Detection of beta-defensins secreted by human oral epithelial cells. (2001) (58)
- Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease (2005) (56)
- Biosynthesis of defensins and other antimicrobial peptides. (1994) (54)
- Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism (2018) (54)
- Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. (1983) (53)
- Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract (2005) (53)
- Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. (2011) (53)
- Antimicrobial proteins and peptides in host defense. (2001) (52)
- Faculty Opinions recommendation of A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins. (2004) (51)
- Antimicrobial Proteins and Peptides (2001) (51)
- Activated alpha 2-macroglobulin is a principal defensin-binding protein. (1991) (51)
- Cellular Catabolism of the Iron-Regulatory Peptide Hormone Hepcidin (2013) (51)
- Interaction of Human Defensins with Escherichia coni (1989) (50)
- Defensins: endogenous antibiotic peptides from human leukocytes. (1992) (50)
- Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. (2016) (49)
- Molecular and clinical correlates in iron overload associated with mutations in ferroportin. (2006) (49)
- Testing the iron hypothesis in a mouse model of atherosclerosis. (2013) (49)
- Increased Bronchoalveolar Lavage Human &bgr;-Defensin Type 2 in Bronchiolitis Obliterans Syndrome after Lung Transplantation (2004) (48)
- Increased Genomic Copy Number of DEFA1/DEFA3 Is Associated with Susceptibility to Severe Sepsis in Chinese Han Population (2010) (48)
- Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia (2007) (48)
- Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. (2002) (47)
- A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome (2019) (47)
- Differential Processing of α- and β-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7)* (2009) (47)
- Identification of TWSG 1 as a second novel erythroid regulator of hepcidin expression in murine and human cells (2009) (45)
- ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. (2020) (45)
- Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. (2002) (44)
- Second Round Robin for plasma hepcidin methods : First steps toward harmonization (2012) (44)
- Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2. (1985) (42)
- Liver iron concentrations and urinary hepcidin in β-thalassemia (2007) (42)
- Molecular cloning and tissue expression of porcine beta-defensin-1. (1998) (41)
- Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. (2010) (41)
- Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients (2018) (41)
- Antimicrobial activity of phagocyte granule proteins. (1986) (41)
- Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus (1987) (41)
- Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. (2011) (40)
- Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin (1994) (40)
- Laboratory production of antimicrobial peptides in native conformation. (1997) (40)
- Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets. (1990) (40)
- Animal models of anemia of inflammation. (2009) (39)
- Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M (2005) (39)
- Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism (2009) (38)
- Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype (2018) (38)
- Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. (2001) (38)
- Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice. (1999) (38)
- Oxygen-independent bactericidal systems. Mechanisms and disorders. (1988) (37)
- Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease. (2019) (37)
- Macrophage function. (1993) (36)
- Beta-defensin expression in human mammary gland epithelia. (2000) (35)
- Maternal Hepcidin Determines Embryo Iron Homeostasis. (2020) (34)
- Calcium is an essential cofactor for metal efflux by the ferroportin transporter family (2018) (34)
- Microbiology: Gut defence (2003) (33)
- Oxygen-independent microbicidal mechanisms of phagocytes. (1999) (33)
- Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis (2019) (33)
- Erythroferrone structure, function, and physiology: Iron homeostasis and beyond (2020) (33)
- Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis (2008) (33)
- Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease (2018) (33)
- Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity. (1993) (33)
- Increased serum hepcidin levels during treatment with deferasirox in iron‐overloaded patients with myelodysplastic syndrome (2011) (32)
- Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. (2004) (32)
- Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis. (2018) (31)
- Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis (2019) (31)
- Small cyclic agonists of iron regulatory hormone hepcidin. (2015) (31)
- A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. (2005) (31)
- Hepcidin Expression in Iron Overload Diseases Is Variably Modulated by Circulating Factors (2012) (30)
- Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1. (1990) (30)
- Fatal Attraction Evaded (2001) (29)
- A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis (2015) (29)
- Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. (2017) (28)
- Synergistic activity of rabbit granulocyte peptides against Candida albicans (1986) (28)
- Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia (2017) (27)
- Copy number polymorphisms are not a common feature of innate immune genes. (2006) (27)
- Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk (2020) (27)
- The Erythroid Factor Erythroferrone and Its Role In Iron Homeostasis (2013) (27)
- Microanalysis of antimicrobial properties of human fluids. (2000) (26)
- Iron homeostasis in pregnancy and spontaneous abortion (2018) (26)
- Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy (2013) (26)
- Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome (2011) (26)
- Contribution of rabbit leukocyte defensins to the host response in experimental syphilis (1991) (26)
- Polymorphic expression of defensins in neutrophils from outbred rats (1990) (25)
- Angiogenin: an antimicrobial ribonuclease (2003) (25)
- Thiol-derivatized minihepcidins retain biological activity. (2015) (25)
- Erythroferrone and matriptase‐2 independently regulate hepcidin expression (2017) (25)
- Defensins and Other Antimicrobial Peptides and Proteins (2005) (23)
- Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice (2018) (23)
- Mouse Models of Anemia of Cancer (2014) (23)
- Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. (2015) (23)
- Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. (2020) (23)
- Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age (2013) (22)
- Hepcidin and the global burden of iron deficiency. (2015) (22)
- DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. (2006) (21)
- Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells (2004) (21)
- New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia (2019) (19)
- Chemistry: Rings of destruction (2001) (19)
- CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib (2017) (19)
- Sequential evaluation of serum hepcidin in anemic myeloma patients: Study of correlations with myeloma treatment, disease variables, and anemia response (2009) (19)
- The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. (2021) (18)
- The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia (2011) (18)
- Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. (2002) (18)
- Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate) (2019) (17)
- Murine 32D c13 cells--a transfectable model of phagocyte granule formation. (1995) (17)
- Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections. (2001) (17)
- Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer. (2018) (17)
- In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment (2017) (16)
- Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model (2017) (15)
- Defensins and Other Antimicrobial Peptides: Innate Defense of Mucosal Surfaces (2005) (15)
- Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone. (2021) (15)
- Isocitrate treatment of acute anemia of inflammation in a mouse model. (2016) (14)
- Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. (2013) (13)
- Is TfR2 the iron sensor (2004) (13)
- Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. (2012) (12)
- The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation (2019) (12)
- The Discovery of the Iron-Regulatory Hormone Hepcidin. (2019) (12)
- Inducibility of HBD-2 in acute burns and chronic conditions of the lung. (2003) (12)
- Antibacterial activity of peptides derived from envelope glycoproteins of HIV‐1 (2003) (12)
- Antimicrobial peptides and proteins in the CF airway. (2002) (11)
- In Chronic Inflammation, There Exists an IL-6 Independent Pathway for the Induction of Hepcidin. (2004) (11)
- Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils1 (2002) (11)
- Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy (2020) (9)
- Hepcidin and Iron in Health and Disease (2022) (9)
- Iron Metabolism in Chronic Kidney Disease Patients. (2019) (9)
- [Hepcidin and Plasmodium falciparum malaria in anemic school children in Mali]. (2009) (9)
- Iron‐related markers are associated with infection after liver transplantation (2017) (9)
- Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat (2018) (9)
- Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines (1993) (9)
- The utility of detecting of autoantibodies against neutrophil cytoplasmic components in Wegener's granulomatosis. (1989) (9)
- Hepcidin Suppression By Momelotinib Is Associated with Increased Iron Availability and Erythropoiesis in Transfusion-Dependent Myelofibrosis Patients (2018) (8)
- Treatment With Minihepcidin Peptide Improves Anemia and Iron Overload In a Mouse Model Of Thalassemia Intermedia (2013) (8)
- The effect of biotinylation on the antigenic specificity of anti-defensin monoclonal antibodies. (1993) (8)
- Parenteral iron therapy and phosphorus homeostasis: A review (2021) (8)
- Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice. (2021) (7)
- Does Pathological Iron Overload Impair the Function of Human Lungs? (2017) (7)
- Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia. (2021) (7)
- Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples. (2021) (7)
- Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis (2021) (7)
- Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. (2017) (7)
- Immunoassay for human serum hepcidin. Commentary (2008) (7)
- Neutrophils and host defense. (1988) (6)
- P105 Decrease in intra- and extra-cellular free iron species and oxidative stress parameters and increase in serum and urinary hepcidin during treatment with deferasirox in iron-loaded patients with MDS (2009) (6)
- HEPCIDIN IS THE PRINCIPLE MEDIATOR OF ANEMIA OF INFLAMMATION (2005) (6)
- BLUNTED HEPCIDIN RESPONSE TO ORAL IRON CHALLENGE IN HFE-HEMOCHROMATOSIS (2007) (6)
- Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice (2021) (6)
- Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. (2018) (6)
- Concurrent Treatment with Minhepcidin and Deferiprone Improves Anemia and Enhances Reduction of Spleen Iron in a Mouse Model of Non-Transfusion Dependent Thalassemia (2014) (6)
- New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis (2022) (5)
- Hepcidine et infection due à Plasmodium falciparum chez un groupe d'écoliers anémiés du Mali (2009) (5)
- Expression, purification, crystallization and preliminary X-ray analysis of the cathelicidin motif of the protegrin-3 precursor. (2001) (5)
- Prognostic associations of plasma hepcidin in women with early breast cancer (2020) (5)
- Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial. (2021) (5)
- Erythrocytes and erythroblasts give up iron. (2018) (5)
- Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin. (2021) (5)
- Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors. (2020) (5)
- Defensins in macrophages (1992) (5)
- IL-6 and Anemia of Inflammation. (2007) (5)
- The structure of neutrophil defensin genes (1993) (5)
- Increase of plasma erythroferrone levels during high‐altitude exposure: A sub‐analysis of the TOP OF HOMe study (2021) (5)
- Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD (2019) (5)
- Angiogenin: an antimicrobial ribonuclease (2003) (5)
- Antimicrobial Activity of Leukocytes (2001) (5)
- Direct Inactivation ofViruses byMCP-1andMCP-2,Natural Peptide Antibiotics fromRabbit Leukocytest (1985) (5)
- Iron overload causes a mild and transient increase in acute lung injury (2020) (5)
- Molecular Regulation of Systemic Iron Metabolism (2012) (5)
- The Role of Hepcidin in Iron Homeostasis (2009) (4)
- Urinary Hepcidin Excretion in Patients with Myelodysplastic Syndrome (MDS) and Myelofibrosis (MF). (2006) (4)
- Evaluation of serum markers for improved detection of autologous blood transfusions (2018) (4)
- Human defensin-inspired discovery of peptidomimetic antibiotics (2022) (4)
- 1133 A TIME COURSE OF HEPCIDIN RESPONSE TO ORAL IRON CHALLENGE IN HFE AND TFR2 HEMOCHROMATOSIS PATIENTS (2010) (4)
- Reduced Paneth Cell &agr;-Defensins and Antimicrobial Activity in Ileal Crohn's Disease (2006) (4)
- Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion (2022) (4)
- Proteolytic cleavage of human enteric defensin 5 (HD5) precursor by intestinal proteases (2000) (4)
- Comment on “Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet” (2018) (3)
- Erythropoietin and iron-a conflicted alliance? (2018) (3)
- Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins (2021) (3)
- New regulators of systemic iron homeostasis (2021) (3)
- Structural Aspects of Hepcidin-Ferroportin Binding (2008) (3)
- Maternal Hepcidin Suppression Is Essential for Healthy Pregnancy (2020) (3)
- Secretions Innate Antimicrobial Activity of Nasal (1999) (3)
- Correction to: Iron and infection (2017) (3)
- Differential Processing of - and -Defensin Precursors by (2009) (3)
- Does Gene Therapy in Beta Thalassemia Normalize Novel Markers of Ineffective Erythropoiesis and Iron Homeostasis? (2019) (3)
- IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). (2012) (3)
- Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression. (2022) (3)
- Minihepcidins: Small Peptides Involved in Disulfide Exchange with Ferroportin Act as Agonists (2010) (3)
- Immunoassay for Human Hepcidin in Blood (2008) (3)
- Retraction notice to: The hepcidin-binding site on ferroportin is evolutionarily conserved. (2014) (3)
- Erythroferrone Regulates Hepcidin Expression Independently of Matriptase 2 (2016) (2)
- The role of hepcidin in fetal iron homeostasis. (2020) (2)
- Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis (2020) (2)
- Hepcidin is elevated in primary and secondary myelofibrosis and remains elevated in patients treated with ruxolitinib (2022) (2)
- Drugging erythroferrone to treat anemias. (2020) (2)
- Solution Structure of Hepcidin-20 (2002) (2)
- Use of Minihepcidins As a “Medical Phlebotomy” in the Treatment of Polycythemia Vera (2014) (2)
- Functional expression in Xenopus oocytes reveals that human ferroportin is an iron exporter shared with zinc (2010) (2)
- Urinary Hepcidin in Thalassemic Syndromes. (2005) (2)
- Hepcidin-Induced Hypoferremia Is a Host-Defense Mechanism Against Siderophilic Bacteria (2013) (2)
- Identification of hepcidin antagonists through a high throughput screening approach (2010) (2)
- NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges (2017) (2)
- Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis (2020) (2)
- Blood Disorders in the Elderly: Iron and aging (2007) (1)
- Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells’ Reactive Oxygen Species and Inflammation Prevent Polycythemia (2018) (1)
- Association of Cirrhosis and Increased Risk of Cardiovascular Events in a VA Patient Population, A Retrospective Cohort Study (2020) (1)
- INTERLEUKIN-6 INDEPENDENT REGULATION OF HEPCIDIN IN ANEMIA OF INFLAMMATION (2007) (1)
- Rapid Communication Activated oe-Macroglobulin Is a Principal Defensin-binding Protein (1991) (1)
- ActivityChemokines Display Defensin-Like Antimicrobial CXC - Cutting Edge: IFN-Inducible ELR (2001) (1)
- Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. (2021) (1)
- Hepcidin Contributes to Anemia of Malignancy by Causing Sequestration of Iron in Hepatic Stores. (2004) (1)
- A Novel Sandwich ELISA to Quantify Erythroferrone in Mouse Serum (2019) (1)
- Anemia of chronic disease (2019) (1)
- Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism (2020) (1)
- Anemia of Inflammation in Patients with Intestinal Failure on Home Parenteral Nutrition (2020) (1)
- Antimicrobial Response to Dramatically Enhance the Epidermal By IL-1 Signaling, Monocyte-Derived Cells (2013) (1)
- Ectopic Hepcidin Production in Anemia of Cancer (2008) (1)
- In iron‐deficient mouse pregnancies, erythroferrone contributes to iron mobilization for embryo erythropoiesis (2022) (1)
- Mice Lacking Liver‐Specific [beta]‐Catenin Develoop Steatohepatitis and Fibrosis After Iron Overload (2017) (1)
- Growth factors EGF and HGF suppress hepcidin by direct interference with bone morphogenetic protein signaling (2010) (1)
- The role of hepcidin in anemia of inflammation and anemia of cancer (2008) (1)
- Normal Hemoglobin Concentrations in Obstructive Sleep Apnea and Associated Neocytolysis-Mediated Hemolysis and Inflammation Mediated Suppression of Expected Elevated Hemoglobin (2019) (1)
- Hepcidin and iron regulation, ten years later (2011) (1)
- Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease (2022) (1)
- Hepcidin: an emerging biomarker for iron disorders, inflammatory diseases, and infections (2010) (1)
- Antimicrobial peptides: from host defense to therapeutics (2001) (1)
- Hepcidin independent anemia of inflammation (2010) (1)
- Role of Erythroferrone in the Pathophysiology of Common Anemias (2014) (1)
- Two Mouse Models Illustrate Different Mechanisms of Anemia of Cancer (2010) (0)
- Comparative analysis of the functional properties of human and mouse ferroportin. (2023) (0)
- Erythroferrone Modulates Iron Distribution for Fetal Erythropoiesis (2021) (0)
- Hepcidin Suppression Following Phlebotomy Is Regulated by an Erythropoietic Regulator Found in Serum. (2006) (0)
- Hepcidin Inhibits Ferroportin Activity Via a Rapid, Low‐Affinity, and Calcium‐Dependent Mechanism in Xenopus Oocytes Independent of Endocytosis (2021) (0)
- Calcium is an essential cofactor for metal efflux by the ferroportin transporter family (2018) (0)
- ferroportin: structure-function study The N-terminus of hepcidin is essential for its interaction with (2013) (0)
- Hepcidin Protects Against Extracellular Infections By Eliminating Non-Transferrin-Bound Iron (2016) (0)
- Hepcidin‐regulated and hepcidin–independent iron release pathways in hepatocytes and macrophages (2008) (0)
- Ferric pyrophosphate citrate for parenteral administration of maintenance iron: structure, mechanism of action, clinical efficacy and safety (2022) (0)
- Determinants Of Tissue Iron Loading In Transfused and Non-Transfused β-Thalassemia and Sickle Cell Disease Patients – Biomarkers Of Iron Regulation and Inflammation (2013) (0)
- NON-TRANSFERRIN-BOUND IRON (NTBI) IS ESSENTIAL FOR RAPID GROWTH AND VIRULENCE OF VIBRIO VULNIFICUS (2016) (0)
- Characterization of the Erythroferrone Structural Domains Relevant for Its Iron-Regulatory Function (2022) (0)
- Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron‐deficient mouse pregnancies (2022) (0)
- Hepcidin in Male Double Red Blood Cell Donors - Relationship Between Parameters of Iron Metabolism and Erythropoiesis (2011) (0)
- Identification of erythroferrone as an erythroid regulator of iron metabolism (2014) (0)
- Ferroportin‐mediated cellular iron efflux requires extracellular calcium (2015) (0)
- A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection (2022) (0)
- Mice Lacking β‐catenin In Liver Develop Hepatic Fibrosis In Response To Iron Overload (2015) (0)
- Human Beta Defensin 2 Is Absent in Burn Blister Fluid: 182. (2000) (0)
- Reduced Paneth cell a-defensins in heal Crohn's disease (2005) (0)
- Defensins and Cathelicidins: Antimicrobial Peptide Effectors of Mammalian Innate Immunity (2002) (0)
- Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis (2007) (0)
- RED CELLS , IRON , AND ERYTHROPOIESIS Erythroferrone contributes to recovery from anemia of in fl ammation (2014) (0)
- Preface: iron and cancer. (2013) (0)
- Ferroportin residue C326 is critical for its interaction with hepcidin (2008) (0)
- Association of Increased Risk of Atherosclerotic Cardiovascular (ASCVD) Event in Chronic Liver Disease Patients with and without Cirrhosis (2022) (0)
- IL-6 is necessary for the induction of hepcidin by inflammation (2004) (0)
- by Altering Membrane Permeability Granulysin, a T Cell Product, Kills Bacteria (2000) (0)
- Correction to Supporting Information for Chen et al., Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis (2022) (0)
- TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis (2023) (0)
- THE ROLE OF IRON AND HEPCIDIN IN YERSINIA ENTEROCOLITICA INFECTION (2016) (0)
- Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension (2022) (0)
- Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat (2018) (0)
- Defensin-2 b Antimicrobial Peptide Human the Tracheobronchial Epithelial Cells Induces Activation of Toll-Like Receptor 2 on Human (2003) (0)
- 5 REGULATION OF HEPCIDIN RELEASE BY IL-6 AND DIETARY IRON IN HUMAN VOLUNTEERS. (2004) (0)
- Faculty Opinions recommendation of BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. (2009) (0)
- Recoveryfrombloodlossrequiresagreatlyenhancedsupplyofirontosupportexpandederythropoiesis.Afterhemorrhage, suppressionoftheiron-regulatoryhormonehepcidinallowsincreasedironabsorptionandmobilizationfromstores.Weidentified anewhormone,erythroferrone(ERFE),thatmediateshepcidinsuppressionduringstresseryt (2014) (0)
- Reconstitution of active NADPH oxidase in nonhematopoietic cells: a milestone in the study of a complex system (2002) (0)
- Human defensin-5 immunohistochemistry and Paneth cell morphology helps to differentiate Crohn's colitis from active ulcerative colitis (2000) (0)
- Characterization of Hepcidin-Inducing Cytokines in Multiple Myeloma. (2009) (0)
- P034 Urinary hepcidin excretion in patients with myelodysplastic syndrome (MDS) and myelofibrosis (MF) (2007) (0)
- The Authors Reply (2020) (0)
- Micrococcus luteus and its peptidoglycan Increased inflammation in lysozyme M-deficient mice in response to (2013) (0)
- Hepcidin. (2020) (0)
- The determinants of hepcidin‐ferroportin interaction (2009) (0)
- partial dependence on hepcidin A mouse model of anemia of inflammation: complex pathogenesis with (2014) (0)
- Altered Hepcidin Regulation in Hereditary Hemochromatosis (2006) (0)
- 1 TIME COURSE OF HEPCIDIN RESPONSE TO ORAL IRON TEST CLARIFIES THE ROLE OF HFE AND TFR2 IN IRON SENSING (2010) (0)
- Small Peptide Agonists and Antagonists of the Iron Regulatory Hormone Hepcidin (2011) (0)
- Faculty Opinions recommendation of Synthesis and characterization of human alpha-defensins 4-6. (2004) (0)
- Evidence Of Relative Iron Deficiency in Apheresis Platelet Donors Correlates With Donation Frequency (2013) (0)
- OP-NDTJ180322 2051..2088 (2019) (0)
- Isocitrate Reverses Anemia of Inflammation in a Mouse Model Treated with Heat-Killed Brucella Abortus (2014) (0)
- Isolation and thermal stabilization of mouse ferroportin (2020) (0)
- Cell proliferation in liver in response to iron overload is dependent on β‐catenin in male mice (2012) (0)
- Iron in Transfusion Medicine: Consequences of Too Much or Too Little (2017) (0)
- Human enteric defensin-5 (HD5) expression in acute pouchitis (2000) (0)
- Brief Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5 (cid:1) -UTR of the HAMP gene (2004) (0)
- Transgenic Mice Overexpressing Erythroferrone, a Novel Erythrokine, Develop Iron Overload and Multi-Organ Iron-Independent Abnormalities (2020) (0)
- erythropoiesis in humans in vivo: data from the HIGHCARE project Modulation of hepcidin production during hypoxia-induced (2012) (0)
- Iron Deficiency without Anemia In Premenopausal Blood Donors Is Associated with Future Deferral From Whole Blood Donation. (2010) (0)
- Faculty Opinions recommendation of MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing. (2003) (0)
- Pathogenic Mechanisms in Thalassemia II: Iron Overload. (2023) (0)
- Upregulation of human defensin-5 in acute pouchitis suggests an infectious etiology (2000) (0)
- Hepatocyte growth factor (HGF) suppresses hepcidin expression in hepatocytes by interfering with BMP‐mediated hepcidin induction (2009) (0)
- Enteric defensin in Crohn's disease and ulcerative colitis (2000) (0)
- Intracellular Pathogens for Antimicrobial Activity against Macrophages Acquire Neutrophil Granules (2006) (0)
- Is Serum Hepcidin a Useful Diagnostic Test for Iron Deficiency (2010) (0)
- THE METABOLIC FATE OF THE PEPTIDE HORMONE HEPCIDIN (2011) (0)
- Effect of defensin HNP-1 of human neutrophils on production of tumor necrosis factor α by human blood monocytes in vitro (1992) (0)
- Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms. (2023) (0)
- downregulation of hepcidin expression mutation is associated with R200W VHL Chuvash polycythemia (2012) (0)
- HEPCIDIN MEDIATES HOST DEFENSE AGAINST GRAM-NEGATIVE PATHOGENS BY CONTROLLING NON-TRANSFERRIN-BOUND IRON (2017) (0)
- IOD IN RHINOS—IMMUNITY GROUP REPORT: REPORT FROM THE IMMUNITY, GENETICS AND TOXICOLOGY WORKING GROUP OF THE INTERNATIONAL WORKSHOP ON IRON OVERLOAD DISORDER IN BROWSING RHINOCEROS (FEBRUARY 2011) (2012) (0)
- Additive Effects of Decreased TfR1 and Ablated Erfe Improve Both Ineffective Erythropoiesis and Iron Overload in β-Thalassemic Mice (2018) (0)
- Faculty Opinions recommendation of Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. (2006) (0)
- Hepcidin interaction with ferroportin in the Xenopus oocyte expression system (2018) (0)
- THE IRON-HYPOXIA LINK: HEPCIDIN HAS A CENTRAL ROLE IN THE RESPONSE TO ACUTE AND CHRONIC EXPOSURE TO HYPOBARIC HYPOXIA. DATA FROM THE HIGHCARE PROJECT: PP.12.453 (2010) (0)
- Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease (2022) (0)
- Oligomerization of ferroportin and the mechanism of autosomal dominance in ferroportin disease (2018) (0)
- Contents Vol. 4, 2012 (2012) (0)
- Altered Hepcidin Regulation in Hereditary Hemochromatosis and Dysmetabolic Hyperferritinemia. (2005) (0)
- The Role of the Iron Transporter Zip8 in Pulmonary Host Defense (2020) (0)
- S1109 The Role of Hepcidin in Crohn's Disease (CD)-Associated Anemia (2009) (0)
- culture through hemojuvelin and BMP2/4 Iron transferrin regulates hepcidin synthesis in primary hepatocyte (2010) (0)
- What can urine teach us about intestinal defense (1998) (0)
- Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia. (2023) (0)
- Placental Ferroportin Protein Abundance Is Associated With Neonatal Rather Than Maternal Iron Status in Women at High Risk for Gestational Iron Insufficiency (2022) (0)
- Patients More on Prognostic Significance of Flt3/itd Size in Acute Myeloid Leukemia (aml) (0)
- Iron metabolism and innate immunity (2009) (0)
- Determinants of Staphylococcus aureus Nasal Carriage (2001) (0)
- ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles ” (1999) (0)
- Faculty Opinions recommendation of Bacteria-selective synergism between the antimicrobial peptides alpha-helical magainin 2 and cyclic beta-sheet tachyplesin I: toward cocktail therapy. (2001) (0)
- Sensing Iron: Reciprocal Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin. (2005) (0)
- Nutrient Sensing , Nutrition , and Metabolism Hamp 1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice (2017) (0)
- Abstract P3-08-08: Prognostic associations of plasma hepcidin in early breast cancer (BC) (2018) (0)
- Common Growth Factors Human Keratinocytes , a Consequence of Antimicrobial Peptides / Polypeptides in Wound Healing and Expression of (2003) (0)
- P028 - The role of hepcidin in Crohn's disease associated anemia (2009) (0)
- Faculty Opinions recommendation of Discovery of multiple beta-defensin like homologues in teleost fish. (2006) (0)
- THE PATHOGENESIS OF HEREDITARY HEMOCHROMATOSIS (2009) (0)
- Dependent on Interleukin-6 Pathogen-Derived Molecules Is Strongly Hepcidin Induction by Pathogens and (2014) (0)
- The Effect of IL‐6 in the Anemia of Inflammation (2008) (0)
- Faculty Opinions recommendation of The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides. (2006) (0)
- High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists s (2013) (0)
- Mini-Hepcidins Prevent Iron Overload In A Mouse Model of Hereditary Hemochromatosis (2011) (0)
- Cell-Neutrophil Interactions Urethritis Reveal Novel Epithelial Chlamydia trachomatis and gonorrhoeae Neisseria Distinct Defensin Profiles in (2005) (0)
- Hepcidin inhibits ferroportin in the Xenopus oocyte expression system via a calcium‐dependent mechanism that does not involve endocytosis (2020) (0)
- Hepcidin Suppression Relative to Iron Status in Patients with Chronic Hepatitis C. (2008) (0)
- The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice (2023) (0)
- Structural Study of the Pro-Sequence of Protegrin-3 (2001) (0)
- 4 IN VITRO ANALYSIS OF IRON-REGULATED HEPCIDIN EXPRESSION. (2004) (0)
- Helicobacter pylori and IL-1 upregulate the expression of human b-defensin (HBD)-2 but not HBD-1 in gastric epithelium (2000) (0)
- Functional properties of mouse ferroportin, a cellular iron‐export protein (2019) (0)
- Expression of defensins in human renal cell carcinomas (1997) (0)
- Antimicrobial Peptides: Defensins and Cathelicidins (2010) (0)
- Erythroferrone Overexpression Impairs Survival and Greatly Increases Tissue Iron Loading in a Mouse Model of β-Thalassemia (2022) (0)
- Commentary to: “Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin,” by Erika Valore and Tomas (2008) (0)
- P027-The usefulness of fecal calprotectin in distinguishing between non-active inflammatory bowel diseases and functional bowel disorders (2009) (0)
- The suppression of hepcidin by anemia and erythropoietin (EPO) is mediated by a fall in serum iron (2006) (0)
- Solution Structure of Hepcidin-25 (2002) (0)
- The Role of Hepcidin in Anemia of Cancer (2008) (0)
- Activite antimicrobienne des chimiokines elr- inductibles par interferon (2003) (0)
- Response to “Elevated Fibroblast Growth Factor 23 and decreased Klotho levels are associated with diastolic dysfunction in CKD G4-5D patients” (2020) (0)
- gene HAMP-UTR of the ′ mutation in the 5 Severe hemochromatosis in a Portuguese family associated with a new (2004) (0)
- The molecular basis of iron metabolism (2019) (0)
- Serum Hepcidin Antimicrobial Peptide Levels Predict Infection After Lung Transplantation (2014) (0)
- Erythron to the Liver: Send Iron (2014) (0)
- William Ganz and His Legacy (2019) (0)
- Hepcidin-The Culprit Explaining Disturbed Iron Homeostasis in Chronic Renal Disease?: IL-6 Mediates Hypoferremia of Inflammation by Inducing the Synthesis of the Iron Regulatory Hormone Hepcidin. J Clin Invest 113:1271-1276, 2004. (2005) (0)
- Increased BAL human β-defensin-2 bronchiolitis obliterans syndrome after lung transplantation (2002) (0)
- Differential Processing of (cid:1) - and (cid:2) -Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7) * (2020) (0)
- Comment on “Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet” (2018) (0)
- Ceruloplasmin Is Essential for the Mobilization of Tissue Iron Stores. (2005) (0)
- Erythroferrone Represses Hepcidin Expression in a Mouse Model of Malaria (2014) (0)
- 12 BACTERIAL VAGINOSIS IS ASSOCIATED WITH DEFICIENCY OF ANTIMICROBIAL SUBSTANCES IN VAGINAL FLUID. (2004) (0)
- EFFECT OF A COLLABORATIVE WEANING PLAN ON LONG TERM VENTILATOR PATIENTS IN THE CRITICAL CARE SETTING (1999) (0)
- a 1 -Acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma (2010) (0)
- HEPCIDIN MODULATION AS A TREATMENT FOR ANEMIA OF INFLAMMATION (AI) (2008) (0)
- Hepcidin Overproduction Mediates the Anemia of Multiple Myeloma. (2006) (0)
- Hamp 1 mRNA and plasma hepcidin levels are influenced by sex and 1 strain but don ’ t predict tissue iron levels in inbred mice 2 3 (2017) (0)
- 1015 DYSMETABOLIC HEPATIC IRON OVERLOAD SYNDROME: ANALYSIS OF HEPCIDIN RESPONSE TO ACUTE ORAL IRON AND CHRONIC IRON OVERLOAD (2009) (0)
- THE ROLE OF BONE MORPHOGENETIC PROTEIN 6 IN THE ANEMIA OF LUNG CANCER (2009) (0)
- Fluids Bactericidal Properties of Porcine Inflammatory Elastase-Activated Polypeptides in the The Role of Protegrins and Other (1998) (0)
- IRON HOMEOSTASIS AND ITS DISORDERS IN MICE AND MEN: POTENTIAL LESSONS FOR RHINOS (2012) (0)
- Detection of a Small‐Volume Autologous Blood Transfusion by Hepcidin, Erythroferrone, and the Athlete Biological Passport (2021) (0)
- PS1294 MULTIFACTORIAL HEPCIDIN SUPPRESSION IN BETA-THALASSEMIA CARRIERS WITH IRON OVERLOAD (2019) (0)
- Hepcidin: looking back at two decades of progress (2022) (0)
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Other Resources About Tomas Ganz
What Schools Are Affiliated With Tomas Ganz?
Tomas Ganz is affiliated with the following schools:
- University of California, Berkeley
- University of Delaware
- California Institute of Technology
- University of California, Los Angeles
- University of Montpellier
- Stanford University
- University of Iowa
- University of Bern
- National and Kapodistrian University of Athens
- University of Turin
- University of Utah
- Harvard University