Toshihiro Nukiwa

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Toshihiro Nukiwa

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Philosophy

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Toshihiro Nukiwa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. (2010) (4109)
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012) (1089)
Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. (2005) (851)
Pirfenidone in idiopathic pulmonary fibrosis (2009) (726)
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. (2006) (502)
Molecular basis of alpha-1-antitrypsin deficiency. (1988) (501)
Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002). (2013) (492)
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. (2009) (478)
Severe acute interstitial pneumonia and gefitinib (2003) (446)
A Japanese Lung Cancer Registry Study: Prognosis of 13,010 Resected Lung Cancers (2008) (396)
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial. (2019) (378)
Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. (2008) (359)
Epidemiology of sarcoidosis in Japan (2008) (300)
Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. (2005) (277)
Alveolar macrophages release an insulin-like growth factor I-type molecule. (1988) (262)
Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. (2004) (253)
Proinflammatory Cytokine IL-1β Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiogenic Factors: In Vivo Analysis of Tumor-Stromal Interaction1 (2002) (243)
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. (2020) (242)
Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402. (2008) (219)
Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. (1997) (214)
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis (2008) (206)
Serological diagnosis of idiopathic pulmonary alveolar proteinosis. (2000) (204)
Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors. (2002) (197)
Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE. (2000) (197)
Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations (2009) (197)
Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. (2000) (195)
Arkadia amplifies TGF‐β superfamily signalling through degradation of Smad7 (2003) (194)
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. (1993) (182)
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. (2010) (175)
Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. (2007) (174)
Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. (2010) (173)
Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model. (2011) (173)
Possible Oncogenic Potential of ΔNp73: A Newly Identified Isoform of Human p73 (2002) (162)
Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells (2007) (160)
Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells (2007) (152)
Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart. (2002) (151)
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer (2013) (138)
Increased Susceptibility to LPS-induced Endotoxin Shock in Secretory Leukoprotease Inhibitor (SLPI)-deficient Mice (2003) (136)
Structure of the human neutrophil elastase gene. (1988) (134)
First-Line Gefitinib in Patients Aged 75 or Older With Advanced Non–Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Mutations: NEJ 003 Study (2012) (133)
Mouse SWAM1 and SWAM2 Are Antibacterial Proteins Composed of a Single Whey Acidic Protein Motif1 (2003) (125)
Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. (2002) (121)
Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung. (1995) (121)
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. (2007) (120)
Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73. (2002) (119)
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. (2002) (117)
Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells. (1995) (115)
Myelomonocytic cell lineage expression of the neutrophil elastase gene. (1988) (110)
Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene. (1986) (109)
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. (2003) (106)
Targeting Apoptotic Tumor Cells to FcγR Provides Efficient and Versatile Vaccination Against Tumors by Dendritic Cells 1 (2003) (106)
Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. (1980) (105)
Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis. (2012) (104)
Phase III study comparing gefitinib monotherapy (G) to combination therapy with gefitinib, carboplatin, and pemetrexed (GCP) for untreated patients (pts) with advanced non-small cell lung cancer (NSCLC) with EGFR mutations (NEJ009). (2018) (103)
Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment (2011) (103)
Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections. (2004) (101)
Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of North East Japan Study Group 002 Trial. (2012) (98)
Siiyama (serine 53 (TCC) to phenylalanine 53 (TTC)). A new alpha 1-antitrypsin-deficient variant with mutation on a predicted conserved residue of the serpin backbone. (1991) (98)
Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function (2013) (96)
Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. (2004) (96)
Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1. (2012) (93)
The Multicenter Study of a New Assay for Simultaneous Detection of Multiple Anti-Aminoacyl-tRNA Synthetases in Myositis and Interstitial Pneumonia (2014) (92)
Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis. (2005) (91)
Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902. (2014) (89)
Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer. (2006) (85)
Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. (2005) (84)
Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats. (1999) (81)
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial (2011) (81)
Peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp‐based detection test for gefitinib‐refractory T790M epidermal growth factor receptor mutation (2008) (80)
Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1. (2015) (76)
alpha 1-Antitrypsin nullGranite Falls, a nonexpressing alpha 1-antitrypsin gene associated with a frameshift to stop mutation in a coding exon. (1987) (74)
Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells (2005) (73)
Alpha1-Antitrypsin Deficiency and Emphysema Caused by Homozygous Inheritance of Non-Expressing Alpha1-Antitrypsin Genes (1986) (72)
Multifunctional interleukin‐1β promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion‐, invasion‐ and angiogenesis‐related molecules (2003) (71)
Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy. (2002) (70)
Emphysema associated with complete absence of alpha 1- antitrypsin in serum and the homozygous inheritance [corrected] of a stop codon in an alpha 1-antitrypsin-coding exon. (1988) (69)
First-line gefitinib versus first-line chemotherapy by carboplatin (CBDCA) plus paclitaxel (TXL) in non-small cell lung cancer (NSCLC) patients (pts) with EGFR mutations: A phase III study (002) by North East Japan Gefitinib Study Group. (2016) (68)
Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene. (2000) (68)
Low-Dose Gefitinib Treatment for Patients with Advanced Non-small Cell Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations (2011) (65)
Fcγ Receptor Iib–Deficient Mice Develop Goodpasture's Syndrome upon Immunization with Type IV Collagen (2000) (63)
All-case post-marketing surveillance of 1371 patients treated with pirfenidone for idiopathic pulmonary fibrosis. (2015) (61)
Alpha 1-antitrypsin-deficient variant Siiyama (Ser53[TCC] to Phe53[TTC]) is prevalent in Japan. Status of alpha 1-antitrypsin deficiency in Japan. (1995) (61)
Cathepsin L activity is increased in alveolar macrophages and bronchoalveolar lavage fluid of smokers. (1993) (61)
Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis. (2010) (61)
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor. (2007) (60)
Risk factors for acute exacerbation of idiopathic pulmonary fibrosis--Extended analysis of pirfenidone trial in Japan. (2015) (59)
Phase III study comparing bevacizumab plus erlotinib to erlotinib in patients with untreated NSCLC harboring activating EGFR mutations: NEJ026. (2018) (59)
Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis (2011) (58)
Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice (2002) (58)
Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype. (1987) (57)
Retinoid receptors in the developing human lung. (2002) (55)
Alternative splicing of hMSH2 in normal human tissues (1997) (54)
Diminution of 37-kDa laminin binding protein expression reduces tumour formation of murine lung cancer cells (1999) (52)
NEJ026: Final overall survival analysis of bevacizumab plus erlotinib treatment for NSCLC patients harboring activating EGFR-mutations. (2020) (52)
Characterization of the gene and protein of the alpha 1-antitrypsin "deficiency" allele Mprocida. (1988) (52)
Vaccination of dendritic cells loaded with interleukin-12-secreting cancer cells augments in vivo antitumor immunity: characteristics of syngeneic and allogeneic antigen-presenting cell cancer hybrid cells. (2005) (51)
Detection of human T-cell lymphotropic virus type I-related antibodies in patients with lymphocytic interstitial pneumonia. (1991) (51)
High Level of Vascular Endothelial Growth Factor in Hemorrhagic Pleural Effusion of Cancer (2002) (50)
Phase II Study of Gefitinib Readministration in Patients with Advanced Non-Small Cell Lung Cancer and Previous Response to Gefitinib (2011) (50)
Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection (2009) (50)
Dendritic Cells Pulsed with Live and Dead Legionella pneumophila Elicit Distinct Immune Responses1 (2004) (50)
Macrolide-treated Pseudomonas aeruginosa induces paradoxical host responses in the lungs of mice and a high mortality rate. (2002) (49)
Hepatocyte growth factor in bronchoalveolar lavage fluids and cells in patients with inflammatory chest diseases of the lower respiratory tract: detection by RIA and in situ hybridization. (1997) (48)
Expression of the 37-kDa laminin binding protein in murine lung tumor cell correlates with tumor angiogenesis. (2000) (46)
Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele. (1988) (45)
Secretory leukocyte peptidase inhibitor and lung cancer (2008) (44)
Indoleamine 2,3-dioxygenase. Formation of L-kynurenine from L-tryptophan in cultured rabbit fineal gland. (1978) (43)
Atypical X-linked agammaglobulinemia diagnosed in three adults. (1999) (43)
Characterization of gyrA, gyrB, grlA and grlB mutations in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus. (1998) (42)
Intratracheal gene transfer of decorin reduces subpleural fibroproliferation induced by bleomycin. (2003) (41)
Pharmacokinetic analysis of combination chemotherapy with carboplatin and etoposide in small-cell lung cancer patients undergoing hemodialysis. (2004) (41)
Epidemiological and clinical features of idiopathic pulmonary alveolar proteinosis in Japan (2006) (41)
A prospective survey of idiopathic interstitial pneumonias in a web registry in Japan. (2015) (39)
Final overall survival results of NEJ002, a phase III trial comparing gefitinib to carboplatin (CBDCA) plus paclitaxel (TXL) as the first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations. (2011) (39)
Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung. (1997) (37)
Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer (2004) (37)
A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0405. (2010) (37)
The activation of bovine pineal tryptophan 5‐monooxygenase (1974) (37)
Chromosome band 16q24 is frequently deleted in human gastric cancer (1999) (37)
Successful treatment of carcinomatous meningitis with gefitinib in a patient with lung adenocarcinoma harboring a mutated EGF receptor gene. (2008) (36)
Soluble lnterleukin-2 Receptor in Sera of Patients with Pulmonary Tuberculosis (1991) (36)
Phase II study of erlotinib in Japanese patients with advanced non-small cell lung cancer. (2010) (36)
Deterioration in regional health status after the acute phase of a great disaster: respiratory physicians' experiences of the Great East Japan Earthquake. (2013) (36)
The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis. (2010) (36)
Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSF. (2004) (35)
Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors (2006) (35)
Successful treatment of a case with rapidly progressive Bronchiolitis obliterans organizing pneumonia (BOOP) using cyclosporin A and corticosteroid. (2002) (35)
Nintedanib in Japanese patients with idiopathic pulmonary fibrosis: A subgroup analysis of the INPULSIS® randomized trials (2017) (34)
Secretory leukoprotease inhibitor augments hepatocyte growth factor production in human lung fibroblasts. (2000) (34)
Induction of antitumor immunity by combined immunogene therapy using IL-2 and IL-12 in low antigenic Lewis lung carcinoma (2000) (34)
Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for elderly patients with advanced non-small-cell lung cancer. (2010) (34)
EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method (2016) (34)
Bevacizumab plus erlotinib versus erlotinib alone in Japanese patients with advanced, metastatic, EGFR-mutant non-small-cell lung cancer (NEJ026): overall survival analysis of an open-label, randomised, multicentre, phase 3 trial. (2021) (34)
Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas (2002) (34)
Acute-onset sarcoidosis with erythema nodosum and polyarthralgia (Löfgren's syndrome) in Japan: a case report and a review of the literature. (2006) (34)
Chronic inflammation, lymphangiogenesis, and effect of an anti‐VEGFR therapy in a mouse model and in human patients with aspiration pneumonia (2015) (33)
Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival (2006) (33)
Efficacy of pirfenidone and disease severity of idiopathic pulmonary fibrosis: Extended analysis of phase III trial in Japan. (2015) (33)
Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice (2005) (33)
Non-mutated tumor-rejection antigen peptides elicit type-I allergy in the majority of healthy individuals. (2002) (33)
Interstitial lung disease associated with gefitinib in Japanese patients with EGFR-mutated non-small-cell lung cancer: combined analysis of two Phase III trials (NEJ 002 and WJTOG 3405). (2013) (33)
Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. (2003) (33)
Expression of nucleolar protein p120 predicts poor prognosis in patients with stage I lung adenocarcinoma. (2001) (32)
Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models (2009) (31)
Expression of nucleolar protein p120 in human lung cancer: difference in histological types as a marker for proliferation. (1997) (31)
Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. (2006) (31)
Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes. (1986) (31)
Randomized phase II trial comparing amrubicin with re-challenge of platinum doublet in patients with sensitive-relapsed small-cell lung cancer: North Japan Lung Cancer Study Group trial 0702. (2015) (31)
First-line gefitinib for elderly patients with advanced NSCLC harboring EGFR mutations. A combined analysis of North-East Japan Study Group studies (2015) (31)
Phase II Study of Amrubicin Combined with Carboplatin for Thymic Carcinoma and Invasive Thymoma: North Japan Lung Cancer Group Study 0803 (2014) (29)
Involvement of Fractalkine/CX3CL1 Expression by Dendritic Cells in the Enhancement of Host Immunity against Legionella pneumophila (2005) (29)
Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations (2018) (29)
Comparative in vitro Activity of S-4661, a New Parenteral Carbapenem, and Other Antimicrobial Agents against Respiratory Pathogens (2000) (29)
Tumor suppression induced by intratumor administration of adenovirus vector expressing NK4, a 4-kringle antagonist of hepatocyte growth factor, and naive dendritic cells. (2002) (29)
Gene Therapy with Secretory Leukoprotease Inhibitor Promoter-Controlled Replication-Competent Adenovirus for Non-Small Cell Lung Cancer (2004) (29)
A phase II study of weekly paclitaxel combined with carboplatin for elderly patients with advanced non-small cell lung cancer. (2006) (28)
Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults (2001) (28)
Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small cell lung cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel (NEJ002). (2015) (28)
Contiguous Four‐guanosine Sequence in c‐myc Antisense Phosphorothioate Oligonucleotides Inhibits Cell Growth on Human Lung Cancer Cells: Possible Involvement of Cell Adhesion Inhibition (1997) (28)
Gene Mutations in Lung Cancer: Promising Predictive Factors for the Success of Molecular Therapy (2005) (28)
Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation. (2010) (28)
Effects of catechins on the mouse tumor cell adhesion to fibronectin. (1995) (27)
Carcinoembryonic antigen in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis. (1985) (27)
Purification and some properties of bovine pineal tryptophan 5-monooxygenase. (1974) (27)
Structure of the murine secretory leukoprotease inhibitor (Slpi) gene and chromosomal localization of the human and murine SLPI genes. (1998) (27)
Responses of serum and lung angiotensin-converting enzyme activities in the early phase of pulmonary damage induced by oleic acid in dogs. (1982) (26)
Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes (2005) (26)
Granulocyte‐macrophage colony‐stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long‐term treatment with aerosolized granulocyte‐macrophage colony‐stimulating factor: a case report (2006) (25)
Prevalence of community-acquired respiratory tract infections associated with Q fever in Japan. (2004) (24)
Prognostic value of nucleolar protein p120 in patients with resected lung adenocarcinoma. (1999) (24)
Inhibition of Experimental Metastasis of Human Fibrosarcoma Cells by Anti‐recombinant 37‐kDa Laminin Binding Protein Antibody (1999) (24)
Cis-acting region associated with lung cell-specific expression of the secretory leukoprotease inhibitor gene. (1997) (24)
IgG reactive to CTL-directed epitopes of self-antigens is either lacking or unbalanced in atopic dermatitis patients. (2003) (23)
Cloning and characterization of an α1-antitrypsin like gene 12 kb downstream of the genuine α1-antitrypsin gene (1988) (22)
Factors associated with a poor response to gefitinib in the NEJ002 study: smoking and the L858R mutation. (2015) (22)
Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling. (2014) (22)
Reduction of virulence factor pyocyanin production in multidrug-resistant Pseudomonas aeruginosa (2013) (21)
Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells (2012) (21)
[Alpha 1-antitrypsin deficiency in Japan]. (1996) (21)
siRNA Targeting against EGFR, a Promising Candidate for a Novel Therapeutic Application to Lung Adenocarcinoma (2008) (20)
The role of biomarkers in management of interstitial lung disease: implications of biomarkers derived from type II pneumocytes (2009) (20)
Exogenous recombinant human IL-12 augments MHC class I antigen expression on human cancer cells in vitro. (1998) (20)
Comparative in-vitro activity of carbapenem antibiotics against respiratory pathogens isolated between 1999 and 2000 (2001) (20)
First-line gefitinib therapy for elder advanced non-small cell lung cancer patients with epidermal growth factor receptor mutations: Multicenter phase II trial (NEJ 003 study). (2010) (20)
Uracil/Tegafur Plus Cisplatin with Concurrent Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer (2004) (19)
Randomized phase II trial comparing carboplatin plus weekly paclitaxel and docetaxel alone in elderly patients with advanced non-small cell lung cancer: north japan lung cancer group trial 0801. (2014) (19)
Randomized phase II study of concurrent versus sequential alternating ge fi tinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations : NEJ 005 / TCOG 0902 (2015) (19)
Randomized phase II trial of uracil/tegafur and cisplatin versus vinorelbine and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-small-cell lung cancer: NJLCG 0601. (2013) (19)
Evaluation of dosing designs of carbapenems for severe respiratory infection using Monte Carlo simulation (2007) (19)
Sequential Granulocyte‐Macrophage Colony‐Stimulating Factor Inhalation after Whole‐Lung Lavage for Pulmonary Alveolar Proteinosis. A Report of Five Intractable Cases (2017) (19)
Prospective analysis of the epidermal growth factor receptor gene mutations in non-small cell lung cancer in Japan. (2006) (18)
Identification and characterization of a novel Rho GTPase activating protein implicated in receptor‐mediated endocytosis (2004) (18)
A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography (2010) (17)
Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation (2008) (17)
Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma: A Retrospective Analysis of 286 Patients from NEJ023 Study. (2018) (16)
Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model (2004) (16)
Pirfenidone in idiopathic pulmonary fibrosis: A phase III clinical trial in Japan (2009) (16)
A phase II trial of oral UFT plus cisplatin (CDDP) in patients with non-small cell lung cancer (NSCLC). (2001) (16)
[Management of mycobacteriosis in general hospital without isolation ward for tuberculosis patients. Clinical study on pulmonary tuberculosis associated with lung cancer patients]. (1999) (16)
Real-world treatment of over 1600 Japanese patients with EGFR mutation-positive non-small cell lung cancer with daily afatinib (2019) (16)
A Phase I Study of Amrubicin Combined with Carboplatin for Elderly Patients with Small-Cell Lung Cancer (2006) (16)
Human T-cell lymphotropic virus type I (HTLV-I) carrier with clinical manifestations characteristic of diffuse panbronchiolitis. (1996) (16)
Soluble interleukin-2 receptor in sera of patients with pulmonary tuberculosis. (1991) (16)
NEJ009 trial: A randomized phase III study of gefitinib (G) in combination with carboplatin (C) plus pemetrexed (P) versus G alone in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) with EGFR mutation. (2014) (15)
N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers (2003) (15)
Gene analysis of heterozygous protein C deficiency in a patient with pulmonary arterial thromboembolism. (1992) (15)
Alpha 1-antitrypsin deficiency and emphysema caused by homozygous inheritance of non-expressing alpha 1-antitrypsin genes. (1986) (15)
Mycobacterial hypersensitivity pneumonitis requires TLR9–MyD88 in lung CD11b+ CD11c+ cells (2011) (15)
9LBA A randomized phase III study comparing gefitinib with carboplatin (CBDCA) plus paclitaxel (TXL) for the first-line treatment of non-small cell lung cancer (NSCLC) with sensitive EGFR mutations: NEJ002 study (2009) (15)
Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study. (2019) (15)
Autologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1beta, IL-2, IL-4, and IL-6: possible involvement of dendritic cells. (1999) (14)
Mycobacterium avium genotype is associated with the therapeutic response to lung infection (2013) (14)
A newly recognized acetylated metabolite of arbekacin in arbekacin-resistant strains of methicillin-resistant Staphylococcus aureus. (1998) (14)
Novel arbekacin- and amikacin-modifying enzyme of methicillin-resistant Staphylococcus aureus. (2000) (14)
Regulation of plasmacytoid dendritic cell responses by PIR-B. (2012) (14)
Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet. (2003) (14)
Miliary brain metastases in 2 cases with advanced non-small cell lung cancer harboring EGFR mutation during gefitinib treatment. (2012) (14)
Gefitinib combined survival analysis of the mutation positives from the prospective phase II trials (I-CAMP) (2008) (13)
Secretory leukocyte protease inhibitor modulates urethane-induced lung carcinogenesis. (2014) (13)
Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression (2005) (13)
Massive chest wall tumor diagnosed as Askin tumor. Successful treatment by intensive combined modality therapy in an adult. (1993) (12)
Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia – short term evaluation of safety and tolerability (2014) (12)
Additional treatment with clarithromycin reduces fever duration in patients with influenza. (2014) (12)
Comparison of Gefitinib Versus Chemotherapy in Patients with Non-small Cell Lung Cancer with Exon 19 Deletion. (2015) (12)
Fatal acute interstitial pneumonia in a worker making chips from wooden debris generated by the Great East Japan earthquake and tsunami. (2012) (11)
Phase II study of irinotecan as a third- or fourth-line treatment for advanced non-small cell lung cancer: NJLCG0703. (2013) (11)
Mouse and Human Cell Activation by N-Dodecanoyl-dl-Homoserine Lactone, a Chromobacterium violaceum Autoinducer (2006) (10)
Toll-like receptor 4 potentiates Ca2+-dependent secretion of electrolytes from swine tracheal glands. (2011) (10)
Trends in antimicrobial susceptibility of Streptococcus pneumoniae in the Tohoku district of Japan: a longitudinal analysis from 1998 to 2007. (2010) (10)
Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation (2015) (10)
In Vitro Activity of HSR-903, a New Oral Quinolone, against Bacteria Causing Respiratory Infections (1999) (10)
An overview of respiratory medicine during the Tsunami Disaster at Tohoku, Japan, on March 11, 2011. (2012) (10)
Retinoic acids repress the expression of ETS-1 in endothelial cells. (2001) (9)
Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor‐mutant lung cancer (2017) (9)
A phase II study of first-line afatinib for patients aged ≥75 years with EGFR mutation-positive advanced non-small cell lung cancer: North East Japan Study Group trial NEJ027 (2020) (9)
A change in the number of CCSP(pos)/SPC(pos) cells in mouse lung during development, growth, and repair. (2013) (9)
Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan (2020) (9)
Gefitinib should be cautiously administered to poor performance status patients with non-small-cell lung cancer: results from a prospective feasibility study. (2005) (9)
Daily single-dose regimen and alternate-two-week triple-dose/day regimen of oral ofloxacin for the prophylaxis and control of exacerbations of chronic respiratory tract infections. (1995) (8)
NEJ026: Phase III study comparing bevacizumab plus erlotinib to erlotinib in patients with untreated NSCLC harboring activating EGFR mutations (2016) (8)
[A case of hypersensitivity pneumonitis due to isocyanate exposure showing progression even two months after removal of the antigen]. (1992) (8)
A naturally occurring p73 mutation in a p73‐p53 double‐mutant lung cancer cell line encodes p73α protein with a dominant‐negative function (2003) (8)
Correlative analysis of longitudinal changes in bronchoalveolar lavage, 67gallium scanning, serum angiotensin-converting enzyme activity, chest X-ray, and pulmonary function tests in pulmonary sarcoidosis. (1987) (8)
Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells (2017) (7)
Rapidly progressive primary adenocarcinoma of the lung with signet-ring cells responding to 5-fluorouracil and leucovorin: A case report (1997) (7)
Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated in recent years (1999) (7)
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia (2016) (7)
Bilateral peripheral infiltrates refractory to immunosuppressants were diagnosed as autoimmune pulmonary alveolar proteinosis and improved by inhalation of granulocyte/macrophage-colony stimulating factor. (2012) (7)
Towards an effective gene therapy for idiopathic pulmonary fibrosis: anti-inflammation, antifibrosis, and regeneration. (2002) (7)
Phase II Study of Carboplatin Combined with Biweekly Docetaxel for Advanced Non-small Cell Lung Cancer (2006) (7)
Randomized phase II study of concurrent gefitinib and chemotherapy versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer (NSCLC) with sensitive EGFR mutations: NEJ005/TCOG0902. (2014) (7)
A Case of Cutaneous Infection Caused by Mycobacterium Szulgai with Progression to Acute Respiratory Distress Syndrome (2011) (7)
Updated Analysis of NEJ009: Gefitinib-Alone Versus Gefitinib Plus Chemotherapy for Non–Small-Cell Lung Cancer With Mutated EGFR (2021) (7)
Cloning and characterization of an alpha 1-antitrypsin like gene 12 KB downstream of the genuine alpha 1-antitrypsin gene. (1988) (6)
Effective enrichment strategy for EML4-ALK fusion gene screening in patients with non-small cell lung cancer. (2014) (6)
Randomized, phase II trial comparing amrubicin with topotecan in patients (pts) with previously treated small cell lung cancer (SCLC) (2008) (6)
Phase II study of amrubicin (AMR) and carboplatin (CBDCA) for invasive thymoma (IT) and thymic carcinoma (TC): NJLCG0803. (2013) (6)
Total respiratory system compliance after thoracoplasty. (1998) (6)
Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands. (2013) (6)
A new variant of alpha-1-antitrypsin deficiency (Siiyama) associated with pulmonary emphysema. (1992) (6)
Prognostic factors for patients with metastatic or recurrent thymic carcinoma receiving palliative-intent chemotherapy. (2020) (6)
Identification of a CTL‐directed epitope encoded by an intron of the putative tumor suppressor gene Testin of the common fragile site 7G region: a peptide vaccine candidate for HLA‐B52+ and HLA‐62+ cancer patients (2003) (6)
In vitro antimicrobial activity and penetration rate into sputum of gatifloxacin, a novel 6-fluoro-8-methoxy quinolone, and its therapeutic efficacy in respiratory infections (1999) (6)
Phase I Study Evaluating the Combination of Afatinib with Carboplatin and Pemetrexed After First-line EGFR-TKIs (2018) (6)
Randomized phase II study of carboplatin plus irinotecan versus carboplatin plus amrubicin in patients with chemo-naïve extensive-stage small-cell lung cancer: North Japan Lung Cancer Study Group (NJLCG) 0901. (2017) (6)
Specificity of 4'''-acetylation by an aminoglycoside-modifying enzyme in arbekacin-resistant strains of methicillin-resistant Staphylococcus aureus. (1998) (5)
Alpha-1 antitrypsin deficiency with severe pulmonary emphysema. (2004) (5)
NK4, an Antagonist of Hepatocyte Growth Factor (HGF), Inhibits Growth of Multiple Myeloma Cells In Vitro and In Vivo : A Mouse Model for Molecular Targeting of Angiogenic Growth Factor. (2004) (5)
PP47 First line gefitinib versus first line chemotherapy by carboplatin plus paclitaxel in non-small cell lung cancer patients with EGFR mutations: a phase III study (002) by North East Japan Gefitinib Study Group (2009) (5)
Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. (2019) (5)
A comparative study of biapenem and imipenem/cilastatin for bacterial pneumonia (1995) (5)
All-case post-marketing surveillance (PMS) of pirfenidone in Japan: Clinical characteristics, efficacy and safety profile in >1300 patients with idiopathic pulmonary fibrosis (IPF) (2013) (5)
Antibacterial activity of carbapenems against clinically isolated respiratory bacterial pathogens in Japan between 2005 and 2006. (2007) (5)
Enigma of α1-antitrypsin: α1-antitrypsin Deficiency Reveals a Puzzling Physiological Function (2001) (4)
A phase II trial of weekly paclitaxel and carboplatin for elderly patients with advanced non-small cell lung cancer (NSCLC) (2005) (4)
A novel human monoclonal antibody, TONO‐1, reactive with T‐lymphocytic leukemia cells (1995) (4)
Updated survival outcomes of NEJ005/TCOG0902, a randomized phase II study of concurrent (C) versus sequential alternating (S) gefitinib and chemotherapy in previously untreated non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations. (2017) (4)
Antibiotic susceptibility of the sputum pathogens and throat swab pathogens isolated from the patients undergoing treatment in twenty-one private clinics in Japan. (1995) (4)
A comparative study of biapenem and imipenem/cilastatin for chronic respiratory tract infection. (1995) (4)
[Familial occurrence of diffuse panbronchiolitis accompanied with elevation of cold agglutinin titer in a father and his two daughters]. (1982) (4)
Clinical evaluation of ciprofloxacin for bacterial pneumonia - Phase III comparative study of intravenous ciprofloxacin versus ceftazidime (1997) (3)
[In vitro activity of biapenem (BIPM) against clinically isolated respiratory pathogens in 1996-1998]. (1999) (3)
Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells (1998) (3)
[Relapsing polychondritis with idiopathic hypoparathyroidism]. (2003) (3)
[Two cases of mediastinal goiter with progressive deviation of the trachea by its growth and their thyroid hormone values in the fluid of the cystic lesions]. (1990) (3)
[A case of diffuse panbronchiolitis, performed an open lung biopsy after improvement with 6 years medication]. (1991) (3)
An ectopic ACTH-producing small cell lung carcinoma associated with enhanced corticosteroid biosynthesis in the peritumoral areas of adrenal metastasis. (2012) (3)
Drug-induced interstitial pneumonia. (2006) (3)
Current status and future perspectives of cooperative study groups for lung cancer in Japan. (2014) (3)
Phase II study of amrubicin combined with carboplatin for refractory relapsed small-cell lung cancer: North Japan Lung Cancer Group Trial 0802. (2014) (3)
Emphysema Associated with Complete Absence of a I -Antitrypsin of a Stop Codon in an a I -Antitrypsin-Coding Exon (2006) (3)
[Bronchial artery embolization can be effective for primary racemose hemangioma]. (2003) (3)
Presence of atypical laminin on the surface of mouse Lewis lung carcinoma cells. (1996) (3)
First-line gefitinib for elderly patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations: A combined analysis of NEJ studies. (2012) (3)
[A case of mediastinal lymphatic cyst possibly originating from the right thoracic duct]. (1992) (3)
Enigma of alpha1-antitrypsin: alpha1-antitrypsin deficiency reveals a puzzling physiological function. (2001) (2)
Phase II study of amrubicin (AMR) combined with carboplatin (CBDCA) for refractory relapsed small cell lung cancer (SCLC): North Japan Lung Cancer Group 0802. (2012) (2)
Randomized phase II trial of daily administration versus alternate-day administration of S-1 in patients with advanced non-small cell lung cancer (2017) (2)
P2.14-52 The Results from Plasma EGFR Mutation Analysis in NEJ026 Study (2019) (2)
P3.01-035 Post-Marketing Observational Study of Japanese Patients with EGFR Mutation-Positive (EGFRm+) NSCLC Treated with Daily Afatinib (Final Report) (2017) (2)
O1-21-2RANDOMIZED PII OF CONCURRENT VS SEQUENTIAL ALTERNATING GEFITINIB AND CHEMOTHERAPY IN EGFR-MUTANT NSCLC: NEJ005/TCOG0902 (2014) (2)
[Pulmonary thromboembolism associated with antiphospholipid syndrome in scleroderma]. (1997) (2)
Variety of laminin expressions in murine neoplastic cell-lines - neuroblastoma na cells produce only laminin-b2 chain. (1994) (2)
[Antibiotic susceptibility and beta-lactamase activity of pathogenic microbes isolated in Miyagi Prefecture between December in 1999 and February in 2000]. (2002) (2)
Pirfenidone, A Novel Anti-fibrotic Agent, Provides Higher Benefit For Idiopathic Pulmonary Fibrosis (IPF) Patients With Better Pulmonary Function (2010) (2)
Weekly irinotecan combined with carboplatin for patients with small-cell lung cancer: A phase I study. (2015) (2)
Arkadia ampli ® es TGF-b superfamily signalling through degradation of Smad 7 (2)
[Alpha 1-antitrypsin genes in patients with alpha 1AT deficiency in Japan: mutational analysis and allelic background]. (1992) (2)
[Studies on respiratory infections in primary care clinic (V). The pattern of distribution on bacteria, Mycoplasma pneumoniae and virus isolated from patients with respiratory infections, who were seen in six private clinics, and clinical efficacy of ciprofloxacin and roxithromycin]. (1994) (2)
Thyroid metastasis of pulmonary adenocarcinoma. (2005) (2)
Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings. (2008) (1)
Preliminary report on DU-6859a for lower respiratory tract infection (1996) (1)
[Analysis of mediastinal lymphadenopathy in sarcoidosis with transesophageal ultrasonic endoscopy; influences on cardiovascular system]. (1989) (1)
Randomized phase II trial of tegafur-uracil (UFT) and cisplatin versus vinorelbine and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-small cell lung cancer: NJLCG 0601. (2010) (1)
Immunohistochemical detection of the laminin receptor polypeptide, a putative precursor of 67-kda-laminin receptor, in human lung-cancer. (1995) (1)
Clinical significance of serum SP-D as a biomarker for antifibrotics in idiopathic pulmonary fibrosis (IPF): Post hoc analysis of a phase 3 trial of pirfenidone in Japan (2019) (1)
Final result of phase II study of amrubicin (AMR) combined with carboplatin (CBDCA) for elderly patients with small cell lung cancer (SCLC). (2009) (1)
[The clinical manifestation of ocular and non-ocular findings in sarcoidosis]. (1985) (1)
Acute eosinophilic pneumonia associated with the inhalation of phosgene gas under the presence of cigarette smoking (2011) (1)
Randomized phase 2 trial comparing amrubicin (A) with re-challenge of platinum doublet (P) in patients (pts) with sensitive-relapsed small-cell lung cancer (SCLC). (2014) (1)
The launch of Respiratory Investigation and its scope. (2012) (1)
Fc g Receptor IIB–deﬁcient Mice Develop Goodpasture’s Syndrome upon Immunization with Type IV Collagen: A Novel Murine Model for Autoimmune Glomerular Basement Membrane Disease (2000) (1)
Randomized phase II trial of carboplatin combined with weekly paclitaxel (CP) and docetaxel alone (D) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC): NJLCG 0801. (2012) (1)
The efficacy of low-dose gefitinib for advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations: A post-hoc analysis from NEJ002. (2010) (1)
Randomized, phase II trial comparing carboplatin (C) and tri-weekly paclitaxel (tP) with C and weekly paclitaxel (wP) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC) (2008) (1)
Phase I trial of bi-weekly docetaxel combined with carboplatin for patients with non-small cell lung cancer. (2004) (1)
The Proton Pump Inhibitor, Lansoprazole, Reduces Frequency of Exacerbations in Patients With Chronic Obstructive Pulmonary Disease (2011) (1)
Double-blind study on grepafloxacin in chronic respiratory tract infection (1997) (1)
The effect of pirfenidone on the prescription of antibiotics and antitussive drugs in patients with idiopathic pulmonary fibrosis: a post-hoc exploratory analysis of phase III clinical trial. (2021) (1)
Comparative in vitro Activity of Vancomycin and Other Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus and Enterococcus faecium in the Tohoku District of Japan (1998) (1)
Effective detection of the epidermal growth factor receptor mutation in pathologic specimens of non-small cell lung cancer patients by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR Clamp. (2006) (1)
Clinical investigation of ciprofloxacin IV in severe and/or refractory infections in the internal medicine field (1997) (1)
A Case of Small-cell Lung Carcinoma with EGFR Gene Mutation (2011) (1)
[Three cases of surgical treatment of dumbbell neurogenic tumor of the mediastinum--evaluation of intraspinal extension in cases without clinical symptoms]. (1992) (1)
Novel functions of stanniocalcin-1 (STC1) through uncoupling protein 2 (UCP2) up-regulation; promoting survival of cancer cells under oxidative stress and inducing the uncoupling respiration (Warburg effect) (2012) (1)
IS4. Trials in Progress (2012) (1)
S-1 Combined with Bi-Weekly Docetaxel for Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy: A Phase II Study of North Japan Lung Cancer Group (NJLCG0701) (2012) (1)
[Suppressive mechanism of clarithromycin on lipopolysaccharide-induced IL-8 production in human monocytes by mediating AP-1 and NF-kappaB]. (2003) (1)
Real-World Safety and Tolerability of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis: Interim Report of a Post-Marketing Surveillance in Japan (2023) (1)
Clinical Aspects Of Non-Small Cell Lung Cancer Harboring Eml4-Alk Fusion Gene In Tohoku University Hospital (2011) (1)
A multicenter phase I study of adenoviral p53 in Japanese patients with advanced non-small cell lung cancer. (2006) (1)
Design and rationale of the Japanese Idiopathic Interstitial Pneumonias (JIPS) Registry. (2022) (1)
Therapeutic effect of lecithinized superoxide dismutase ( PC-SOD ) on bleomycin-induced pulmonary fibrosis (2009) (1)
Nucleotide sequence analysis of a human monoclonal antibody 22-13 reactive with lung tumor-associated antigen. (1998) (1)
1471PFINAL RESULT OF RANDOMIZED PHASE 2 TRIAL COMPARING AMRUBICIN (A) WITH RE-CHALLENGE OF PLATINUM DOUBLET (P) IN PATIENTS (PTS) WITH SENSITIVE-RELAPSED SMALL-CELL LUNG CANCER (SCLC): NJLCG0702. (2014) (1)
[Expression of hepatocyte growth factor by activated eosinophiles in inflammatory lung tissue]. (1999) (1)
1476PFINAL RESULTS OF A RANDOMIZED PHASE 2 STUDY COMPARING CARBOPLATIN PLUS IRINOTECAN (CI) VERSUS CARBOPLATIN PLUS AMRUBICIN (CA) FOR EXTENSIVE DISEASE SMALL-CELL LUNG CANCER: NJLCG0901. (2014) (0)
[109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium:1. Recent treatments and progress in malignant tumors--chemotherapy and molecular targeting agents antibody therapy; introduction]. (2012) (0)
Anti-fibrotic effects of liver X receptor agonists in human fetal lung fibroblasts (2011) (0)
Clinical Characteristics of Bone Sarcoidosis: 4 Case Series under Treatment (2010) (0)
[Ultrasonographic diagnosis of lung and thoracic diseases]. (1984) (0)
[Gene therapy and clinical trials]. (2002) (0)
Identification of Mycobacterium avium complex isolated in eastern and central Japan by using DNA probes. (1995) (0)
Retrospective Analysis of Acquired Resistance During the Treatment with Gefitinib in Non-Small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Mutations (2009) (0)
Randomized Phase II Trial of Carboplatin Combined with Weekly Paclitaxel (CWP) and Docetaxel Alone (D) in Elderly Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC): NJLCG 0801 (2012) (0)
Randomized phase 2 study of carboplatin plus irinotecan (CI) versus carboplatin plus amrubicin (CA) for extensive disease small-cell lung cancer (ED-SCLC): NJLCG0901. (2014) (0)
Contents Vol. 79, 2010 (2011) (0)
O3-2-1Updated survival outcomes of NEJ005/TCOG0902, a randomized PII of gefitinib and chemotherapy in EGFR-mutant NSCLC (2017) (0)
Abstract 1793: Imatinib treatment for gefitinib-resistant lung cancer harboring epidermal growth factor receptor mutation (2012) (0)
Internal medicine - prospect to twenty-first century. I. Prospects to the twenty-first century on each region of internal medicine. 5. Respiratory organ. (2002) (0)
Aerosolized GM-CSF Therapy of Pulmonary Alveolar Proteinosis (PAP). (2009) (0)
[M. szulgai developed respiratory failure, after presenting with lower leg swelling, skin rash, and multiple lymphadenopathies]. (2009) (0)
Synergistic Anti-Fibrotic Effects Of Pirfenidone And Cyclosporine A On Lung Fibroblasts (2011) (0)
9070 Phase II trial of S-1 with bi-weekly docetaxel for non-small-cell lung cancer previously treated with platinum-based chemotherapy: a North Japan Lung Cancer Study Group (NJLCG0701) (2009) (0)
Different Gene-Expressions In TGF-² Pathway Were Induced By Pirfenidone And Cyclosporine In Human Lung Myofibroblasts (2012) (0)
P1.01-20 Phase III Study Comparing Gefitinib (G) to Gefitinib Combined with Carboplatin and Pemetrexed (GCP) for NSCLC with EGFR Mutations (NEJ009) (2018) (0)
Liver X Receptor Agonists Inhibit TGF-Beta1 Induced Myofibroblast-Differentiation (2011) (0)
Screening of Point Mutations on p53 Gene in Primary Lung Cancer using Single-Strand Conformation Polymorphism Analysis of Polymerase Chain Reaction (2011) (0)
Japanese chest physicians face hopes and enigmas of gefitinib, a molecular targeting drug for lung cancer (2004) (0)
Diagnosis and treatment of new idiopathic interstitial pneumonias cases: Analysis using the Japanese Registry (2020) (0)
[Progress in the filed of pulmonary medicine in the last 100 years: Medical history of interstitial pneumonia]. (2002) (0)
Alveolar Macrophages ReleaseanInsulin-like GrowthFactorI-TypeMolecule (1988) (0)
Fc and Fc-like receptors (PP-095) (2010) (0)
Double-blind study on grepafloxacin in pneumonia (1997) (0)
117. Antitumor Immunity Induced by Adenovirus Vector-Mediated Transduction of OX40 Ligand (2004) (0)
Pirfenidone Delays the Prescription of Concomitant Drugs in Patients with Idiopathic Pulmonary Fibrosis: Post-Hoc Analysis of Japanese Phase III Clinical Trial (2020) (0)
Long-Term Survivors in Non-Small Cell Lung Cancer (NSCLC) Patients with Epidermal Growth Factor Receptor (EGFR) Mutations: Data from a Randomized Phase III Study Comparing GEFITINIB with Carboplatin Plus Paclitaxel (NEJ002) (2012) (0)
Asthma (WS-082) Chairpersons: Hiroshi Nakajima, Dale Umetsu (2010) (0)
Direct Effect Of Vasohibin-1, A Negative Regulator Of Angiogenesis, On Lung Fibroblasts Against Fibrogenesis (2011) (0)
Clinicopathologic Characteristics Of Lung Cancer Occurred In Combined Pulmonary Fibrosis And Emphysema (CPFE) (2011) (0)
Pirfenidone Reduces Serum Level Of SP-D And KL-6, Sensitive Interstitial Biomarkers, Even In Severe Idiopathic Pulmonary Fibrosis (IPF) With Treatment (2011) (0)
Multipotent Stromal Cell-Derived Stanniocalcin-1 Reduces Reactive Oxygen Species And Promotes Survival Of Injured A549 Lung Cancer Cells Through Upregulation Of Uncoupling-Protein 2 And Induction Of The Warburg Effect (2010) (0)
[Idiopathic interstitial pneumonia--its physiopathology and possibility for molecular-targeted control]. (2003) (0)
[Overview of gene transfer in the area of respiratory diseases]. (2005) (0)
3. Clinical Practice of Interstitial Lung Disease (2009) (0)
[Two cases of Legionnaires' disease diagnosed by antigen detection in urine]. (2002) (0)
[Molecular biology of lung neoplasms--progress of the basic understandings of solid tumors in general and the application to clinical study]. (1996) (0)
Microsatellite-Unstable Gastric Cancers Instabilotyping Reveals Unique Mutational Spectra in Updated (2002) (0)
[Recent elucidation of the genetic defects among disease of the chest: cystic fibrosis, chronic granulomatous disease, and alpha 1-antitrypsin deficiency]. (1990) (0)
[Effects of roxithromycin (RXM) on viruses and cultured cells]. (1997) (0)
[NK4 gene therapy]. (2002) (0)
Survey of Acinetobacter baumannii Isolates in a NICU at a General Hospital (2010) (0)
Toll-Like Receptor 4 Signaling As A Potentiator In The Airway Submucosal Gland Secretion (2010) (0)
Correction to: Real-world treatment of over 1600 Japanese patients with EGFR mutation-positive non-small cell lung cancer with daily afatinib (2019) (0)
In vitro antimicrobial activity, penetration into sputum and therapeutic efficacy of grepafloxacin in respiratory tract infections (1990) (0)
Toll-Like Receptor 5 Potentiates Ca2+-Dependent Electrolytes Secretion From Airway Submucosal Gland (2012) (0)
Authors’ Response: Expression of Multiple Corticotropin-Releasing Hormone Receptors in the Human Heart (2002) (0)
IS7. lung cancer (2012) (0)
High carcino embryonic antigen in the lower respiratory tract of patients of idiopathic interstitial pneumonia (1984) (0)
46 A phase II trial of biweekly docetaxel combined with carboplatinfor patients with advanced non-small cell lung cancer (2005) (0)
[A case of pulmonary Langerhans cell histiocytosis discovered by CT mass screening and followed by bronchoalveolar lavage]. (2006) (0)
Preliminary reports Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric (2002) (0)
O1–137PHASEII STUDY OF S-1 WITH IRINOTECAN COMBINATION THERAPY FOR EGFR-MUTATED NSCLC RESISTANT TO EGFR-TKI: NJLCG0804 (2013) (0)
P-glycoprotein (P-gp) May Be Associated with Chemoresistance to Amrubicin (AMR) in Lewis Lung Carcinoma (LLC) Cells. (2009) (0)
479 Amphiregulin contributes to tumor progression in lung adenocarcinoma (2010) (0)
A Mouse Model for Hot Tub Lung by UsingMycobacterium aviumfrom the Patient. (2009) (0)
Final Analysis of Randomized Phase II Trial of Carboplatin Combined with Weekly Paclitaxel (CP) and Docetaxel Alone (D) in Elderly Patients (PTS) with Advanced Non-Small Cell Lung Cancer (NSCLC): NJLCG 0801 (2012) (0)
P2.03-021 A Phase I Study Evaluating the Combination of Afatinib, Carboplatin and Pemetrexed after Failure of 1st Generation EGFR-TKIs (2017) (0)
Nationwide prospective registry of idiopathic interstitial pneumonias with central multidisciplinary diagnosis in Japan (JIPS Registry): Analysis of disease progression (2022) (0)
[A case report of tuberculosis epidemic in a university]. (1996) (0)
Deterioration Of Regional Health Status After Great Disaster; Experience Of The Great East Japan Earthquake (2011 Tohoku Earthquake) (2012) (0)
α1-antitrypsin deficiency as a prototype of pulmonary emphysema (1991) (0)
The Effects Of Clinically Used Phosphodiesterase Inhibitors On Ca2+-Dependent Electrolytes Secretion From Airway Submucosal Gland (2011) (0)
RTP801, An Essential Mediator Of Cigarette Smoke-Induced Emphysema, Is Also Increased In Fibrotic Lesions With And Without Smoking Habits (2011) (0)
[Central Pattern Generators for Breathing and Gait and Possible Medical Application of Oriental BodyWork: Access to Extrapyramidal and Body Trunk Movement System Through Breathing Methods]. (2022) (0)
VASH-1, a Negative Feedback Regulator of Angiogenesis, Is Produced by Lung Myofibroblasts after Differentiation from Fibroblasts and Affects Their Own Proliferation. (2009) (0)
MSCs Ameliorate Elastase Induced Emphysema by Suppressing IL-1b and Inducing Growth Factors. (2009) (0)
Ultrasonographical configuration of thoracic cavities after pleurodesis in patients with malignant pleural effusion (1991) (0)
[A case of neurogenic pulmonary edema with repeated deterioration due to subarachnoid hemorrhage]. (1989) (0)
Randomized Phase II Study of Concurrent Gefitinib Plus Chemotherapy Versus Alternation of Gefitinib and Chemotherapy in Previously Untreated Non-Small Cell Lung Cancer (NSCLC) with Sensitive EGFR Mutations: NEJ005/TCOG0902 (2012) (0)
[Prospect for the 21st century: the respiratory organs]. (2002) (0)
Biphasic Remodeling of Alveolar Capillaries in Idiopathic Pulmonary Fibrosis (2001) (0)
Acute exacerbation of idiopathic pulmonary fibrosis: Analysis in a post-marketing surveillance of pirfenidone (2014) (0)
Chronic solitary pulmonary nodule due to unsuspected pulmonary infarction from silent pulmonary embolism (1996) (0)
Simultaneous Alterations of Gene Expressions in Different Cell Types of Alveolar Septa Induced by Transforming Growth Factor-beta 1 and Recovered by Cyclosporin A. (2009) (0)
Two years of Respiratory Investigation: articles published and upcoming bimonthly publication. (2014) (0)
Diagnostic Value Of Interstitial Biomarkers, KL-6 And SP-D For Progressive Fibrosis In Combined Pulmonary Fibrosis And Emphysema (2011) (0)
Screening of point mutations on p53 gene in tissues from primary lung cancer using single-strand conformation polymorphisms analysis (1991) (0)
Interstitial lung diseases : Advances in diagnosis and treatment.Disease state of idiopathic interstitial pneumonia and complication of lung cancer. (1994) (0)
Book Review Diffuse Lung Disease: A Practical Approach Edited by Robert P. Baughman, Roland M. du Bois, Joseph P. Lynch, and Athol U. Wells. 294 pp., illustrated. London, Arnold, 2004. $125. 0-340-81014-9 (2005) (0)
[Graphic evaluation of the significance band for hypercapnia in pulmonary disorders]. (1992) (0)
[Pre-existing disorders of primary lung cancer: background analysis of multiple primary lung cancer--what are the initiation factors of carcinogenesis?]. (1988) (0)
1284PRANDOMIZED PHASE II STUDY OF CONCURRENT VERSUS SEQUENTIAL ALTERNATING GEFITINIB AND CHEMOTHERAPY IN PREVIOUSLY UNTREATED NON-SMALL CELL LUNG CANCER (NSCLC) WITH SENSITIVE EGFR MUTATIONS: NEJ005/TCOG0902. (2014) (0)
Detection of EGFR gene mutations from daily obtained specimens in NSCLC patients (2006) (0)
Stanniocalcin-1 (STC1) Derived from Bone Multipotent Stromal Cells (MSCs) Inhibit Lung Epithelial Apolptosis under Hypoxia and Lactic Acidosis. (2009) (0)
The Effects of Low Dose Inhaled Carbon Monoxide (CO) on Dyspnea in Patients with Chronic Obstructive Pulmonary Disease (COPD). (2009) (0)
Non-Small Cell Lung Cancer Promoter-Controlled Replication-Competent Adenovirus for Gene Therapy with Secretory Leukoprotease Inhibitor (2004) (0)
Phase I trial of bi-weekly docetaxel combined with carboplatin for patients with non-small cell lung cancer (2004) (0)
monocytes by SAGE Comprehensive gene expression profile of LPS-stimulated human (2011) (0)
Long-term safety of Prolastin®-C, an alpha1-proteinase inhibitor, in Japanese patients with alpha1-antitrypsin deficiency. (2022) (0)
Overall Survival Analysis of Bevacizumab Plus Erlotinib for Advanced EGFR-Mutant Metastatic NSCLC (2021) (0)
Diagnosis of Early Phase of Acute Exacerbation of Idiopathic Pulmonary Fibrosis and Its Successful Treatment by a Neutrophil Elastase Inhibitor. (2009) (0)
Abstract A32: Aberrant gene repression with H3K27me3 modification in human small cell lung cancer (2013) (0)
Clinical usefulness of Z-100 for the treatment of leukopenia induced by radiotherapy. A placebo-controlled double-blind raudomized trial focused on the protection of infection in lung cancer patients. (1999) (0)
Bleomycin - Induced Lung Injury Causes Disturbance Of Tight Junction Of Alveolar Epithelial Cells (2011) (0)
[Gamma-knife radiosurgery for metastatic brain tumors from primary lung cancer]. (1998) (0)
Deletion Of Slpi Reduces Lung Inflammation After Naphtalene Induction (2011) (0)
[Non-small-cell lung cancer (NSCLC) in an elderly patient--a case of squamous cell carcinoma successfully treated with chemotherapy using vinorelbine]. (2001) (0)
Ultrasonographical findings of chest wall tumor in patients with primary and metastatic lung cancer (1991) (0)
Clinical evaluation of pazufloxacin mesilate for bacterial pneumonia: Phase III comparative study of pazufloxacin mesilate versus ceftazidime (2000) (0)
69. Tumor-Targeting Innumogene Therapy by Mesenchymal Stem Cells Expressing CX3CL1 (2005) (0)
[Molecular cellular physiopathology of idiopathic interstitial pneumonia]. (2001) (0)
[Pathophysiology of interstitial lung disease and complication of lung neoplasms]. (1994) (0)
Isoform of Human p 73 Np 73 : A Newly Identified ∆ Possible Oncogenic Potential of Updated (2002) (0)
P2.03-010 Updated Survival Outcomes of NEJ005/TCOG0902, a Randomized PII of Gefitinib and Chemotherapy in EGFR-Mutant NSCLC (2017) (0)
The Occurrence Of Lung Cancer In Patients With Interstitial Pneumonias (2010) (0)
[Idiopathic pulmonary fibrosis: progress in diagnosis and treatment]. (2005) (0)
Current status and study activity of lung cancer in Japan. (2014) (0)
[A case of recurrent pulmonary alveolar proteinosis treated by pulmonary lavage: were the remissions due to the natural course or due to the lavage?]. (1992) (0)
Development Of A Mouse Model For Hot Tub Lung (2010) (0)
[Diffuse lung diseases]. (2006) (0)
Opening Remarks for the 47^ Annual Meeting of the Japanese Respiratory Society (2007) (0)
Effect of Hepatocyte Growth Factor on Lung Injury and Development of Clinical Application (2001) (0)
[New strategies for the etiologic study of interstitial pneumonia: familial registration and sib-pair analysis]. (1996) (0)
[Effect of clarithromycin on monocyte-derived inflammatory cytokine production in bacterial infections with special reference to Mycobacterium avium infection]. (2001) (0)
The Diagnostic Value Of Serum Level Of Surfactant Protein D For The Degree Of Fibrosis After Bleomycin-Induced Lung Injury In Mouse (2012) (0)
Final results of a phase II trial of S-1 with biweekly docetaxel for non-small cell lung cancer previously treated with platinum-based chemotherapy (NJLCG0701). (2010) (0)
A Phase I study of Nedaplatin (CDGP) and docetaxel (TXT) in patients with advanced non-small cell lung cancer (NSCLC) (2000) (0)
3067 Randomized phase II trial of standard daily administration versus alternate-day administration of S-1 in patients with advanced non-small cell lung cancer: North Japan Lung Cancer Group Trial NJLCG1102 (2015) (0)
[Current understanding of interstitial pneumonias and approach for the next treatment]. (2004) (0)
Innate Immunity Mediated By Natural Killer T Cells Is Required For The Development Of Hot Tub Lung In Mice (2012) (0)
Subject Index Vol. 79, 2010 (2011) (0)
[Immunogene therapy for lung cancer]. (2000) (0)
[Biochemical aspects of microvascular injuries caused by various drugs with toxic effects on the lung in dogs]. (1984) (0)
Pivotal Roles of Transforming Growth Factor-beta 1 in Barrier Dysfunction of Alveolar Walls in Lung Injury Prior to Fibrogenesis. (2009) (0)
[A case of sarcoidosis with multiple pulmonary cavities]. (1984) (0)

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Tohoku University

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