Toshimitsu Niwa
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Biology
Toshimitsu Niwa's Degrees
- PhD Biochemistry University of Tokyo
- Masters Molecular Biology University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Toshimitsu Niwa's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular identification of a renal urate–anion exchanger that regulates blood urate levels (2002) (1280)
- Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. (1994) (399)
- Determination of Advanced Glycation End Products in Serum by Fluorescence Spectroscopy and Competitive ELISA (1997) (277)
- Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. (2002) (271)
- Differential accumulation of advanced glycation end products in the course of diabetic retinopathy (1999) (215)
- Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production (2012) (214)
- Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation (2010) (206)
- The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients. (1997) (200)
- Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients. (1997) (197)
- Improvement of renal function with prostaglandin E1 infusion in patients with chronic renal disease. (1974) (196)
- Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. (2002) (186)
- Molecular Identification of a Novel Carnitine Transporter Specific to Human Testis (2002) (184)
- Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains. (1987) (184)
- Interactions of Human Organic Anion Transporters with Diuretics (2004) (181)
- Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography. (1988) (179)
- Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats. (2008) (178)
- Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells. (2009) (177)
- Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate. (1994) (166)
- Indoxyl sulfate is a nephro-vascular toxin. (2010) (165)
- Indoxyl Sulfate Inhibits Nitric Oxide Production and Cell Viability by Inducing Oxidative Stress in Vascular Endothelial Cells (2009) (160)
- 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication. (1999) (130)
- Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. (1996) (127)
- NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. (2011) (126)
- Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis. (2003) (125)
- Potential cardiovascular risk factors in chronic kidney disease: AGEs, total homocysteine and metabolites, and the C-reactive protein. (2004) (124)
- Oxidative stress, advanced glycation end product, and coronary artery calcification in hemodialysis patients. (2006) (122)
- Uremic toxicity of indoxyl sulfate. (2010) (119)
- Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease (2016) (116)
- Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry. (2010) (113)
- Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells. (2012) (112)
- Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB (2013) (110)
- Elevated C-reactive protein levels in patients with polypoidal choroidal vasculopathy and patients with neovascular age-related macular degeneration. (2007) (109)
- Increased glutathionyl hemoglobin in diabetes mellitus and hyperlipidemia demonstrated by liquid chromatography/electrospray ionization-mass spectrometry. (2000) (102)
- Indoxyl Sulfate and Atherosclerotic Risk Factors in Hemodialysis Patients (2007) (98)
- Role of Indoxyl Sulfate in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Experimental and Clinical Effects of Oral Sorbent AST‐120 (2011) (98)
- Efficient removal of albumin-bound furancarboxylic acid, an inhibitor of erythropoiesis, by continuous ambulatory peritoneal dialysis. (1990) (95)
- Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. (2012) (95)
- Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains. (1991) (94)
- Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: The behavioral and biochemical changes (1990) (94)
- Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. (2010) (93)
- Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients. (2005) (92)
- Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients. (1997) (92)
- Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats. (2013) (91)
- Indoxyl Sulfate Reduces Superoxide Scavenging Activity in the Kidneys of Normal and Uremic Rats (2007) (87)
- Modification of beta 2m with advanced glycation end products as observed in dialysis-related amyloidosis by 3-DG accumulating in uremic serum. (1996) (87)
- Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings (2005) (85)
- Indoxyl Sulfate Downregulates Renal Expression of Klotho through Production of ROS and Activation of Nuclear Factor-ĸB (2011) (84)
- Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry. (2010) (83)
- In vitro formation of N(epsilon)-(carboxymethyl)lysine and imidazolones under conditions similar to continuous ambulatory peritoneal dialysis. (2001) (82)
- Interactions of human organic anion as well as cation transporters with indoxyl sulfate. (2003) (81)
- Increased levels of advanced glycation end products in human cataractous lenses (2003) (77)
- Metabolic profiling with gas chromatography-mass spectrometry and its application to clinical medicine. (1986) (77)
- Presence of tetrahydroisoquinoline, a parkinsonism-related compound, in foods. (1989) (76)
- Oral sorbent suppresses accumulation of albumin-bound indoxyl sulphate in serum of haemodialysis patients. (1991) (76)
- Molecular Cloning of a Novel Thyroid Hormone-responsive Gene, ZAKI-4, in Human Skin Fibroblasts* (1996) (74)
- Phenol and p-cresol accumulated in uremic serum measured by HPLC with fluorescence detection. (1993) (70)
- Inhibitory effect of oral sorbent on accumulation of albumin-bound indoxyl sulfate in serum of experimental uremic rats. (1991) (69)
- Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese. (2011) (68)
- Evidence for non‐enzymatic glycosylation of Escherichia coli chromosomal DNA (2005) (68)
- Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats. (2010) (66)
- Update of uremic toxin research by mass spectrometry. (2011) (66)
- Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats. (2011) (66)
- CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells. (2013) (66)
- Removal of Protein-Bound Uraemic Toxins by Haemodialysis (2013) (65)
- Evidence for non‐enzymatic glycosylation in Escherichia coli (2001) (65)
- Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum. (1993) (65)
- Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducing oxidative stress. (2009) (65)
- Amyloid β2-microglobulin is modified with Nε-(carboxymethyl)lysine in dialysis-related amyloidosis (1996) (64)
- Roles of Organic Anion Transporters in the Progression of Chronic Renal Failure (2007) (63)
- Protein-bound molecules: a large family with a bad character. (2014) (62)
- Suppressive effect of an oral sorbent on the accumulation of p-cresol in the serum of experimental uremic rats. (1993) (62)
- Increased erythrocyte 3-DG and AGEs in diabetic hemodialysis patients: role of the polyol pathway. (1999) (62)
- SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients. (2012) (61)
- Pyridoxal phosphate prevents progression of diabetic nephropathy. (2007) (60)
- Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity. (2012) (60)
- Accumulation of furancarboxylic acids in uremic serum as inhibitors of drug binding. (1988) (58)
- Gas chromatographic--mass spectrometric analysis of polyols in urine and serum of uremic patients. Identification of new deoxyalditols and inositol isomers. (1983) (57)
- Mass spectrometry in the search for uremic toxins. (1997) (57)
- Indoxyl sulfate induces nephrovascular senescence. (2012) (56)
- An Oral Adsorbent Downregulates Renal Expression of Genes That Promote Interstitial Inflammation and Fibrosis in Diabetic Rats (2002) (56)
- 3-deoxyglucosone and AGEs in uremic complications: inactivation of glutathione peroxidase by 3-deoxyglucosone. (2001) (56)
- KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects. (2009) (56)
- Amyloid β2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis (1997) (56)
- N2-carboxyethyl-2'-deoxyguanosine, a DNA glycation marker, in kidneys and aortas of diabetic and uremic patients. (2006) (56)
- An oral adsorbent ameliorates renal overload of indoxyl sulfate and progression of renal failure in diabetic rats. (2001) (56)
- Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells (2011) (56)
- Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques (2017) (55)
- Suppressed serum and urine levels of indoxyl sulfate by oral sorbent in experimental uremic rats. (1992) (55)
- Efficient removal of albumin-bound furancarboxylic acid by protein-leaking hemodialysis. (1995) (54)
- Elevated serum levels of 3-deoxyglucosone, a potent protein-cross-linking intermediate of the Maillard reaction, in uremic patients. (1995) (54)
- Mass spectrometry for the study of protein glycation in disease. (2006) (54)
- Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy. (2013) (53)
- Accumulation of indoxyl-beta-D-glucuronide in uremic serum: suppression of its production by oral sorbent and efficient removal by hemodialysis. (1996) (53)
- Dialysis-related amyloidosis of the heart in long-term hemodialysis patients. (2001) (53)
- Accumulation of indoxyl sulfate in OAT1/3-positive tubular cells in kidneys of patients with chronic renal failure. (2006) (53)
- RNA metabolism in uremic patients: accumulation of modified ribonucleosides in uremic serum. Technical note. (1998) (52)
- Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice (2017) (52)
- Imidazolone, a novel advanced glycation end product, is present at high levels in kidneys of rats with streptozotocin‐induced diabetes (1997) (51)
- Immunohistochemical detection of advanced glycation end products in dialysis-related amyloidosis. (1995) (50)
- Two immunochemical assays to measure advanced glycation end-products in serum from dialysis patients (2005) (50)
- GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese. (2005) (50)
- AST-120 for the management of progression of chronic kidney disease (2014) (50)
- Protein glutathionylation and oxidative stress. (2007) (49)
- Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry. (1988) (49)
- Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis. (2005) (49)
- Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells. (2004) (47)
- Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction. (2013) (47)
- Polymorphism of Nrf2, an Antioxidative Gene, is Associated with Blood Pressure and Cardiovascular Mortality in Hemodialysis Patients (2014) (47)
- Biomarker discovery for kidney diseases by mass spectrometry. (2008) (46)
- Indoxyl sulfate-lowering capacity of oral sorbents affects the prognosis of kidney function and oxidative stress in chronic kidney disease. (2007) (46)
- Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells (2014) (46)
- C9-R95X polymorphism in patients with neovascular age-related macular degeneration. (2012) (46)
- Uremic Toxicity: Urinary Indoxyl Sulfate is a Clinical Factor that Affects the Progression of Renal Failure (1999) (44)
- Formation of advanced glycation end products during CAPD. (2003) (44)
- Glucose-modified proteins modulate essential functions and apoptosis of polymorphonuclear leukocytes. (2001) (44)
- Effects of oral adsorbent on gene expression profile in uremic rat kidney: cDNA array analysis. (2003) (43)
- Relative quantification of N(epsilon)-(Carboxymethyl)lysine, imidazolone A, and the Amadori product in glycated lysozyme by MALDI-TOF mass spectrometry. (2003) (43)
- Oral Adsorbent AST-120 Ameliorates Interstitial Fibrosis and Transforming Growth Factor-β1 Expression in Spontaneously Diabetic (OLETF) Rats (2000) (43)
- Pattern of aliphatic dicarboxylic acids in uremic serum including a new organic acid, 2,4-dimethyladipic acid. (1979) (43)
- Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells. (2013) (42)
- An Oral Sorbent, AST-120, Increases Klotho Expression and Inhibits Cell Senescence in the Kidney of Uremic Rats (2009) (42)
- Quantification of serum 1,5-anhydroglucitol in uremic and diabetic patients by liquid chromatography/mass spectrometry. (1994) (42)
- Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells (2014) (42)
- Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin. (1994) (42)
- Significant association between Helicobacter pylori infection and serum C-reactive protein (2008) (42)
- Indoxyl Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3-Mediated Uptake and Activation of AhR/NF-κB Pathway (2014) (41)
- Glutathionyl hemoglobin in uremic patients undergoing hemodialysis and continuous ambulatory peritoneal dialysis. (2001) (41)
- AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats. (2012) (41)
- Glycation and Post-translational Processing of Human Interferon-γ Expressed in Escherichia coli* (2003) (40)
- KLOTHO Gene Polymorphisms G-395A and C1818T Are Associated with Low-Density Lipoprotein Cholesterol and Uric Acid in Japanese Hemodialysis Patients (2009) (40)
- Recent progress in the analysis of uremic toxins by mass spectrometry. (2009) (39)
- Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells. (2014) (38)
- Advanced glycation end-products and peritoneal sclerosis. (2004) (38)
- Role of advanced glycation end products and growth factors in peritoneal dysfunction in CAPD patients. (2003) (37)
- Tryptophan and indolic tryptophan metabolites in chronic renal failure. (1980) (36)
- Inhibition of mitochondrial respiration by furancarboxylic acid accumulated in uremic serum in its albumin-bound and non-dialyzable form. (1993) (36)
- Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. (2004) (36)
- Advanced glycation endproducts (AGE) on IgG, a target for circulating antibodies in North American Indians with rheumatoid arthritis (RA). (1998) (36)
- Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence (2012) (35)
- Targeting protein-bound uremic toxins in chronic kidney disease (2013) (35)
- Combination Therapy with Benazepril and Oral Adsorbent Ameliorates Progressive Renal Fibrosis in Uremic Rats (2002) (34)
- Analysis of polyols in uremic serum by liquid chromatography combined with atmospheric pressure chemical ionization mass spectrometry. (1993) (34)
- Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. (2009) (34)
- Dialysis‐Related Amyloidosis: Pathogenesis Focusing on AGE Modification (2001) (32)
- Effect of hemodialysis on plasma levels of vasoactive peptides: endothelin, calcitonin gene-related peptide and human atrial natriuretic peptide. (1993) (32)
- Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry. (1992) (32)
- Are advanced glycation end products cardiovascular risk factors in patients with CRF? (2003) (32)
- Indoxyl Sulfate Enhances p53-TGF-β1-Smad3 Pathway in Proximal Tubular Cells (2013) (31)
- Indoxyl sulfate upregulates renal expression of icam-1 via production of ros and activation of nf-κb and p53 in proximal tubular cells (2012) (31)
- Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage. (2004) (31)
- Preventive Effects of an Oral Sorbent on Nephropathy in Rats (1999) (31)
- Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry. (1989) (30)
- Unified capillary chromatography (1988) (29)
- β2-Microglobulin Dialysis Amyloid and Its Formation: Role of 3-Deoxyglucosone and Advanced Glycation End Products (1997) (29)
- Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation. (2013) (29)
- Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells (2017) (28)
- Signal transduction of beta2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts. (2002) (27)
- Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS. (2013) (27)
- Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells. (2012) (27)
- Coronary artery calcification score is associated with mortality in Japanese hemodialysis patients. (2012) (26)
- Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration (2010) (26)
- Determination of glutathionyl hemoglobin in hemodialysis patients using electrospray ionization liquid chromatography-mass spectrometry. (1999) (26)
- Novel Mutations (H337R and 238–362del) in the CPS1 Gene Cause Carbamoyl Phosphate Synthetase I Deficiency (2001) (25)
- Dialysis-related spinal canal stenosis: a clinicopathological study on amyloid deposition and its AGE modification (2000) (25)
- Analysis of glutathionyl hemoglobin levels in diabetic patients by electrospray ionization liquid chromatography-mass spectrometry: effect of vitamin E administration. (2000) (25)
- Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of N-methylisoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline. (1990) (25)
- Advanced glycation end products (AGEs)-induced expression of TGF-beta 1 is suppressed by a protease in the tubule cell line LLC-PK1. (2001) (25)
- Rapid detection of deletion mutations in inherited metabolic diseases by melting curve analysis with LightCycler. (2000) (25)
- Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis. (1991) (24)
- Serum levels of 3-deoxyglucosone and tissue contents of advanced glycation end products are increased in streptozotocin-induced diabetic rats with nephropathy. (1996) (24)
- Serum pyridinolines as specific markers of bone resorption in hemodialyzed patients. (1995) (24)
- Oral sorbent AST-120 increases renal NO synthesis in uremic rats. (2008) (24)
- Gas chromatographic-mass spectrometric profile of organic acids in urine and serum of diabetic ketotic patients. (1981) (23)
- Oral adsorbent ameliorates renal TGF-β1 expression in hypercholesterolemic rats (1999) (23)
- Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients (2006) (23)
- Profiling of uremic ultrafiltrate using high resolution gas chromatography-mass spectrometry - identification of 6 polyphenols. (1980) (23)
- Identification and quantification of a protein-bound ligand in uremic serum. (1987) (22)
- Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease. (2013) (22)
- Urinary prostaglandins and thromboxane in patients with chronic glomerulonephritis. (1987) (22)
- Immunohistochemical detection of imidazolone and N(epsilon)-(carboxymethyl)lysine in aortas of hemodialysis patients. (1998) (21)
- Rapid assay for indoxyl sulphate in uremic serum by internal-surface reversed-phase high-performance liquid chromatography. (1988) (21)
- Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin. (2002) (21)
- Experimental induction of AGEs in fetal L132 lung cells changes the level of intracellular cathepsin D. (1999) (21)
- Ultrastructural localization of advanced glycation end products and beta2-microglobulin in dialysis amyloidosis. (2000) (20)
- Advanced glycation end products contribute to the immunogenicity of IFN-β pharmaceuticals. (2012) (19)
- Plasma indoxyl sulfate and estimated glomerular filtration rate. (2014) (19)
- Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells (2016) (18)
- Localization of imidazolone in the peritoneum of capd patients: a factor for a loss of ultrafiltration. (2001) (18)
- POLYMORPHISMS OF NRF2, AN ANTIOXIDATIVE GENE, ARE ASSOCIATED WITH BLOOD PRESSURE IN JAPANESE (2014) (17)
- Carbamoyl phosphate synthetase I deficiency: molecular genetic findings and prenatal diagnosis (2001) (17)
- Mutation Analysis in a Patient with Succinic Semialdehyde Dehydrogenase Deficiency: A Compound Heterozygote with 103–121del and 1460T > A of the ALDH5A1 Gene (2002) (17)
- Cell-wash dialysis (CWD). (1980) (17)
- Retention behaviour in liquid and supercritical fluid chromatography using methanol or diethyl ether as mobile phase (1987) (17)
- Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells. (2015) (16)
- Immunohistochemical detection of an AGE, a ligand for macrophage receptor, in peritoneum of CAPD patients. (2003) (16)
- Chemical and physiological relevance of glucose degradation products in peritoneal dialysis. (2012) (16)
- Clinical effects of selective thromboxane A2 synthetase inhibitor in patients with nephrotic syndrome. (1988) (16)
- Analysis of salsolinol in human brain using high-performance liquid chromatography with electrochemical detection. (1988) (16)
- A gas chromatographic-mass spectrometric analysis for phenols in uremic serum. (1981) (16)
- Presence of tetrahydroisoquinoline-related compounds, possible MPTP-like neurotoxins, in parkinsonian brain. (1993) (16)
- Fate of the glucose degradation products 3-deoxyglucosone and glyoxal during peritoneal dialysis. (2005) (15)
- Stepwise gradient elution using switching valves in micro high-performance liquid chromatography (1987) (15)
- An inhibitor of advanced glycation end product formation reducesNϵ-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats (2003) (15)
- Multiplex PCR with confronting two-pair primers for CYP1A1 Ile462Val, GSTM1, GSTT1, and NQO1 C609T. (2005) (14)
- Involvement of interleukin-8 in dialysis-related arthritis. (1998) (14)
- Gas chromatographic-mass spectrometric analysis of erythrocyte 3-deoxyglucosone in hemodialysis patients. (1999) (14)
- Amyloid beta 2-microglobulin is modified with N epsilon-(carboxymethyl)lysine in dialysis-related amyloidosis. (1996) (14)
- Interleukin 8 and biocompatibility of dialysis membranes. (1995) (14)
- Metabolic syndrome defined by new criteria in Japanese is associated with increased liver enzymes and C-reactive protein. (2008) (14)
- Simultaneous detection of methylenetetrahydrofolate reductase gene polymorphisms, C677T and A1298C, by melting curve analysis with LightCycler. (2002) (14)
- Gas chromatographic-mass spectrometric analysis of organic acids in renal tissue biopsy: identification of 4-hydroxybutyric acid and 4-hydroxy-2-butenoic acid. (1982) (14)
- Glycation and post-translational processing of human interferon-gamma expressed in Escherichia coli. (2003) (13)
- Mass spectrometry in diabetes mellitus. (1995) (13)
- Profiling of organic acids and polyols in nerves of uraemic and non-uraemic patients. (1986) (13)
- Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. (2020) (12)
- A novel mutation (E358K) in the α‐galactosidase A gene detected in a Japanese family with Fabry disease (1998) (12)
- Urinary trehalase activity in chronic glomerulonephritis. (1993) (12)
- An inhibitor of advanced glycation end product formation reduces N epsilon-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats. (2003) (12)
- Unchanged serum levels of advanced glycation endproducts in patients with liver disease (2007) (12)
- Enzyme immunoassay for urinary albumin at low concentration in diabetes mellitus. (1990) (11)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- New Syntheses of 6-Deoxy-L-gulose and 6-Deoxy-L-talose (1986) (11)
- Immunochemical detection of imidazolone in uremia and rheumatoid arthritis. (2000) (10)
- Mass spectrometry in uremia. (1995) (10)
- 3-Hydroxyhexanoic acid: an abnormal metabolite in urine and serum of diabetic ketoacidotic patients. (1985) (10)
- Amyloid beta 2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis. (1997) (10)
- Detection and characterization of modified nucleosides in serum and urine of uremic patients using capillary liquid chromatography-frit-fast atom bombardment mass spectrometry. (2000) (10)
- Problems with activated charcoal and alumina as sorbents for medical use. (2008) (10)
- Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine. (1994) (10)
- Maillard Reaction Products in the Escherichia coli–derived Therapeutic Protein Interferon Alfacon‐1 (2008) (9)
- Molecular insights into preventive effects of AST-120 on the progression of renal failure (2001) (9)
- Advanced glycation end products are associated with beta 2-microglobulin amyloidosis. (1995) (9)
- Presence of N-methyldopamine in parkinsonian and normal human brains. (1993) (8)
- Molecular heterogeneity of amyloid beta2-microglobulin and modification with advanced glycation end products. (2001) (8)
- Myoinositol inhibits proliferation of cultured Schwann cells: evidence for neurotoxicity of myoinositol. (1989) (8)
- Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry. (1995) (8)
- Gas chromatographic-mass spectrometric determination of erythrocyte 3-deoxyglucosone in diabetic patients. (2002) (8)
- Application of micro HPLC to the analyis of amino acids after precolumn derivatization with O-phthalaldehyde and N-acetyl-L-cysteine (1988) (7)
- Identification of 2-hydroxy-2-methyllevulinic acid in urine and serum of diabetic patients with ketoacidosis. (1982) (7)
- Identification of 6-deoxyallitol and 6-deoxygulitol in human urine. Electron-impact mass spectra of eight isomers of 6-deoxyhexitol. (1984) (7)
- Amine metabolite profile of normal and uremic urine using gas chromatography--mass spectrometry. (1982) (7)
- Rapid assay for furancarboxylic acid accumulated in uremic serum using high-performance liquid chromatography and on-line mass spectrometry. (1994) (7)
- Characterization of antibody affinities using an AGE-modified dipeptide spot library. (2002) (7)
- The role of carbon adsorbent in the conservative management of chronic kidney disease. (2017) (7)
- Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats. (2011) (6)
- Ischemic change of organic acids in kidney. (1983) (6)
- Analysis of urinary organic acids by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. (1993) (6)
- Clinical and biochemical findings of a patient with thanatophoric dysplasia type I: additional finding of dicarboxylic aciduria. (2002) (6)
- Gas chromatographic-mass spectrometric identification of isosaccharino-1,4-lactone in human serum and urine. (1980) (6)
- Porous glass beads as stationary phase in supercritical fluid chromatography (1988) (6)
- Biomedical mass spectrometry (2013) (6)
- Identification of some abnormal metabolites in psoriatic nail using gas chromatography--mass spectrometry. (1980) (6)
- Indoxyl Sulfate-induced Vascular Calcification is mediated through Altered Notch Signaling Pathway in Vascular Smooth Muscle Cells (2020) (6)
- Procedures for MS analysis of clinically relevant compounds. (1995) (5)
- Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital. (2004) (5)
- [Effect of oral sorbent, AST-120, on serum concentration of indoxyl sulfate in uremic rats]. (1990) (5)
- Proteome Analysis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients (2006) (5)
- Oral adsorbent ameliorates renal TGF-beta 1 expression in hypercholesterolemic rats. (1999) (5)
- Immunohistochemical Detection of Imidazolone in Kidneys of NSY Mice (1998) (5)
- Maillard reaction and immunogenicity of protein therapeutics (2016) (4)
- Hemodiafiltration with sodium concentration-controlled dialysate. (1980) (4)
- Precolumn concentration and/or stepwise-gradient elution by switching valve techniques in micro high-performance liquid chromotography (1987) (4)
- Gas chromatographic-mass spectrometric analysis of amine metabolites in urine. (1982) (4)
- Basic theory of mass spectrometry. (1995) (4)
- Clinical mass spectrometry. Introduction. (1995) (4)
- Therapeutic application of phenylalanine immunoadsorbent with on-line regeneration. (1987) (4)
- Plasma exchange for treatment of intractable psoriasis. (1983) (4)
- Cardiac Troponin T and Advanced Glycation End-Products in Hemodialysis Patients (2008) (4)
- Mass spectrometry in disorders of organic acid metabolism. (1995) (4)
- Medical mass spectrometrist (MMS) training and certification: A key step to expanding routine clinical mass spectrometry usage in Japan (2020) (3)
- B-type natriuretic peptide and cardiovalvulopathy in Parkinson disease with dopamine agonist (2009) (3)
- Analysis of tetrahydroisoquinolines in the brain by gas chromatography/mass spectrometry (1993) (3)
- Subject Index Vol. 76,1997 (1997) (3)
- [Thromboxane A2 metabolism and clinical effects of selective thromboxane A2 synthetase inhibitor in patients with chronic glomerulonephritis]. (1987) (3)
- Uremic Toxins: Niwa/Uremic Toxins (2012) (3)
- Mass-spectral analysis of human interferon-gamma and chloramphenicol acetyltransferase I produced in two Escherichia coli strains. (2000) (3)
- The roles of the Multiplex PCR with Confronting Two-pair Primers for CYP 1 A 1 Ile 462 Val , GSTM 1 , GSTT 1 , and NQO 1 C 609 T (2005) (3)
- A gas chromatographic-mass spectrometric assay for nine hydroxyphenolic acids in uremic serum. (1979) (2)
- Analysis of Uremic Toxins with Mass Spectrometry (2012) (2)
- A case of lupus nephritis showing rectal erosion with cytomegalovirus infection. (1991) (2)
- Iindoxyl Sulfate, A Tryptophan Metabolite, Induces Nephro-Vascular Toxicity (2012) (2)
- Tetrahydroisoquinoline and its derivatives: the occurrence and the metabolism in the brain, and the effects on catecholamine metabolism (1991) (2)
- Beta2-Microglobulin dialysis amyloid and its formation: role of 3-deoxyglucosone and advanced glycation end products. (1997) (2)
- 4. Indoxyl Sulfate (2012) (2)
- 3‐Carboxy‐4‐Methyl‐5‐Propyl‐2‐Furanpropionic Acid (2012) (2)
- Molecular Cloning of Rat ZAKI-4 Gene (1996) (2)
- Post-translational Processing of Human Interferon- γ Produced in Escherichia coli and Approaches for its Prevention (2008) (2)
- Separation of oligomers by supercritical fluid chromatography with an open-tubular glass capillary silica gel column (1988) (2)
- Endogenous MPTP-Like Amines in the Brain: Isoquinolines (1994) (1)
- Comparison of nephrotoxicity of pirarubicin and doxorubicin (1998) (1)
- Clinical and Biochemical Findings of a Patient with Thanatophoric Dysplasia Type I: Additional Finding of Dicarboxylic Aciduria (2002) (1)
- Therapeutic Removal of Uremic Toxins by Oral Sorbent (2012) (1)
- Extracorporeal dialysis: techniques and adequacy (2011) (1)
- Rapid Genotyping of 2-bp and 9-bp Deletion Mutations Using the LightCycler Instrument (2002) (1)
- Influence of AHRR Pro189Ala polymorphism on kidney functions (2017) (1)
- [Oral sorbent]. (2004) (1)
- C 9-R 95 X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration (2012) (1)
- Subject Index, Vol. 63, 1993 (1993) (1)
- Mass spectrometry in Parkinson's disease. (1995) (1)
- Mass spectrometry in hepatic diseases. (1995) (1)
- Advances in Nutrition and Metabolism in Renal Disease: Introduction (2003) (0)
- Present conditions of research on substances causing uremia in 1998 - Current Concept of the 43rd Japan Dialysis Medical Society. (1998) (0)
- Indoxyl Sulphate is Associated with Cardiac Dysfunction in Patients with Dilated Cardiomyopathy (2011) (0)
- The 32nd Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry. Preface. (2008) (0)
- Hyperlipidemia and tissue contents of N epsilon-(carboxymethyl)lysine in streptozotocin diabetes. (1997) (0)
- Uremic toxin-induced nephro-vascular injury and thrombophilia (2015) (0)
- [Analysis of organic acids in uremic serum during intravenous infusion of essential amino acids using gas chromatography-mass spectrometry]. (1983) (0)
- Experimental models of CKD (2013) (0)
- Uremia research and toxicity. (2010) (0)
- [SHORT REPORTS]Suppression of Cerebral Gene (UAB3) Expression under Uremia (1994) (0)
- 1,3-DIARYLCYCLOPROPENES: SYNTHESES AND A FACILE ENE DIMERIZATION (1985) (0)
- Polymorphism in Patients with Neovascular Age-Related Macular Degeneration (2012) (0)
- Investigation of removal of protein-bound compounds accumulated in uremic serum. (1989) (0)
- 39th and 40th Annual Meetings of the Japanese Society for Biomedical Mass Spectrometry (JSBMS): New Applications of Mass Spectrometry in Biomedicine (2014) (0)
- 24th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry, Hyogo, Japan, 23-25 September, 1999. (2000) (0)
- Reducing Tryptophan Metabolites to Reduce Progression in Chronic Kidney Failure (2013) (0)
- Title Pages / Contents (1999) (0)
- Contents, Vol. 15, 1995 (1995) (0)
- Subject Index Vol. 29, 2009 (2009) (0)
- Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry (1990) (0)
- GC/MS study on metabolism of tetrahydroisoquinoline, an endogenous MPTP-like substance, in brain (1989) (0)
- Contents Vol. 29, 2009 (2009) (0)
- Dicarboxylic aciduria and 3-hydroxycarboxylic aciduria in a patient of thanatophoric dysplasia type I (2000) (0)
- [A gas chromatographic-mass spectrometric analysis of organic acids in uremic ultrafiltrate (author's transl)]. (1981) (0)
- Immunohistochemical demonstration of advanced glycation end products in synovial amyloid deposits of patients on long-term hemodialysis (1995) (0)
- Hyperlipidemia and Tissue Contents of Nε-(Carboxymethyl)lysine in Streptozotocin Diabetes (1997) (0)
- Sixth International Congress on Uremia Research and Toxicity, Sinaia, Romania, 18-19 October 2009. (2010) (0)
- Biocompatibility of hemodialysis membranes assessed on the basis of changes in gene expression and plasma interleukin-8 levels (1995) (0)
- Erratum to the special issue of the Japanese Society for Biomedical Mass Spectrometry [J. Chromatogr. B, 731 (1999)]☆ (1999) (0)
- Indoxyl sulfate in hemodialysis patients (1988) (0)
- New challenge of mass spectrometry technique (2007) (0)
- Contents, Vol. 64,1993 (1993) (0)
- New Syntheses of 6-Deoxy-L-gulose and 6-Deoxy-L-talose. (1987) (0)
- Inhibitory effect of furancarboxylic acid, a protein-bound uremic toxin, on mitochondrial respiration. (1992) (0)
- A case of IgD type multiple myeloma after long-term hemodialysis (1986) (0)
- Wiley Series on Mass Spectrometry (2012) (0)
- Subject Index Vol. 25, 1999 (1999) (0)
- [Therapeutic effect of prostaglandin E1 infusion in chronic renal patients with decreased renal function]. (1983) (0)
- Cardiovascular complications - 1 (2009) (0)
- Molecular Cloning of RMPQ, a Gene Containing CAG Triplet Repeats from Rat Mesangial Cells (1998) (0)
- Effects of Bifidobacteria in a astroresistant Seamless Capsule on yperhomocysteinemia in Hemodialysis atients (0)
- Editorial: Mass spectrometry for the study and diagnosis of human disease (2006) (0)
- Organic Acids And Other Metabolites In Renal Failure And Their Removal With Blood Purification Procedures (1984) (0)
- Parkinsoism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice (1990) (0)
- AnalytIcal Recovery of a-D-lsosaccharlno-1 , 4-lactone Added to Ultraflltrate (2004) (0)
- Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry (JSBMS) (2006) (0)
- Title Page. Should Microalbuminuria Ever Be Considered as a Renal Endpoint in Any Clinical Trial? (2010) (0)
- [Analysis of phenols in uremic serum by gas chromatography-mass spectrometry (author's transl)]. (1981) (0)
- 33rd Annual Meeting Of The Japanese Society For Biomedical Mass Spectrometry. (2009) (0)
- Overview of Uremic Toxins (2020) (0)
- 38th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry (JSBMS): New Applications of Mass Spectrometry in Biomedicine (2014) (0)
- Contents, Vol. 69, 1995 (1995) (0)
- Associations between disease risk and eight polymorphisms adopted for genotype announcements at Nagoya University Hospital. (2004) (0)
- Chronic Kidney Disease : Early Detection by Ningen Dock Followed by Dietary and Lifestyle Guidance (2015) (0)
- Contents Vol. 25, 1999 (1999) (0)
- Subject Index Vol. 15, 1995 (1995) (0)
- GC/MS and LC/MS analysis of urinary carbohydrates and polyols in galactosemia (1995) (0)
- Reduced Circulating AGE Levels and Lower Genomic Damage in Patients Undergoing Daily versus Standard Hemodialysis (2005) (0)
- Subject Index Vol. 69, 1995 (1995) (0)
- Effect of oral sorbent on a protein-bound uremic toxin, indoxyl sulfate, accumulated in serum of hemodialysis patients. (1991) (0)
- Uremia research and toxicity. (2012) (0)
- Association Between Gamma-Glutamyltranspeptidase Levels and Genetic Polymorphisms of Alcohol-Metabolizing Enzymes in Japanese Population (2005) (0)
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What Schools Are Affiliated With Toshimitsu Niwa?
Toshimitsu Niwa is affiliated with the following schools:
