Toshio Hirano | Academic Influence

Toshio Hirano's AcademicInfluence.com Rankings

Toshio Hirano

Biology

#2187

World Rank

#3506

Historical Rank

Immunology

#96

World Rank

#102

Historical Rank

Neuroscience

#428

World Rank

#447

Historical Rank

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Biology

Toshio Hirano's Degrees

Bachelors Biology University of Tokyo
Masters Immunology University of Tokyo
PhD Immunology University of Tokyo

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Why Is Toshio Hirano Influential?

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According to Wikipedia, is a Japanese immunologist and academic, best known for his discovery of interleukin-6. Since August 2011, he has served as the 17th President of Osaka University. Chronology 1972—graduated from Graduate School of Medicine, Osaka University1980—assistant professor in the School of Medicine, Kumamoto University1984—assistant professor at Institute for Molecular and Cellular Biology, Osaka University1989—professor at the same university2004—Dean of Graduate School of Frontier Biosciences, Osaka University2008—Dean of Graduate School of Medicine, Osaka UniversityAugust 2011—the 17th president of Osaka University

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Toshio Hirano's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin (1986) (2056)
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas (1988) (1730)
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family. (1990) (1449)
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 (1989) (1353)
Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF) (1990) (1322)
Molecular cloning and expression of an IL-6 signal transducer, gp130 (1990) (1181)
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors (2000) (1175)
IL-6 is produced by osteoblasts and induces bone resorption. (1990) (1129)
Biological and clinical aspects of interleukin 6. (1990) (1074)
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. (1988) (943)
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003) (797)
Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis (1988) (791)
IL-6 in autoimmune disease and chronic inflammatory proliferative disease. (2002) (791)
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells (1988) (784)
Interleukin 6 and its receptor: ten years later. (1998) (761)
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. (1996) (692)
IL-6 signal transduction and its physiological roles: the signal orchestration model. (2003) (685)
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). (1985) (672)
A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells. (1996) (617)
IgG1 plasmacytosis in interleukin 6 transgenic mice. (1989) (607)
Infection with HIV is associated with elevated IL-6 levels and production. (1990) (602)
Molecular regulation of B lymphocyte response. (1988) (554)
COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome (2020) (545)
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes (1988) (530)
Zinc is a novel intracellular second messenger (2007) (527)
AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. (1990) (494)
Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. (2008) (488)
Structure and expression of human B cell stimulatory factor‐2 (BSF‐2/IL‐6) gene. (1987) (483)
IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation1 (2004) (470)
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. (1989) (457)
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells (1989) (456)
Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes (1988) (442)
Interleukin-6 is a potent thrombopoietic factor in vivo in mice. (1989) (439)
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. (1999) (426)
How COVID-19 induces cytokine storm with high mortality (2020) (425)
Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6 (1988) (423)
Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas (1989) (419)
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene (1999) (417)
Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. (2000) (407)
Induction of rat acute‐phase proteins by interleukin 6 in vivo (1988) (393)
Signaling mechanisms through gp130: a model of the cytokine system. (1997) (391)
Zinc homeostasis and signaling in health and diseases (2011) (378)
Extracellular signal‐dependent nuclear import of Stat1 is mediated by nuclear pore‐targeting complex formation with NPI‐1, but not Rch1 (1997) (377)
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer (2004) (361)
IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. (1988) (346)
Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. (1987) (343)
Molecular structure of human lymphocyte receptor for immunoglobulin E (1986) (329)
Toll-like receptor–mediated regulation of zinc homeostasis influences dendritic cell function (2006) (326)
Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses (2008) (313)
Intracellular zinc homeostasis and zinc signaling (2008) (313)
Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. (1988) (305)
Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase (1998) (303)
FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane (2005) (297)
In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets. (1990) (290)
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. (1989) (288)
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. (1988) (286)
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene (1990) (278)
Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells. (1988) (276)
Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells (1987) (273)
Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier (2012) (273)
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression (1987) (270)
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. (2000) (269)
Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines. (2019) (261)
Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation (2000) (259)
STAT3 orchestrates contradictory signals in cytokine‐induced G1 to S cell‐cycle transition (1998) (258)
IL-6 in inflammation, autoimmunity and cancer (2020) (256)
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. (2007) (254)
Action of recombinant human interleukin 6, interleukin 1β and tumor necrosis factor α on the mRNA induction of acute‐phase proteins (1988) (238)
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. (1992) (237)
Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule. (2008) (236)
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis (2002) (234)
The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways (2008) (232)
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. (1996) (230)
Interleukin-6 and its relation to inflammation and disease. (1992) (226)
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. (1999) (226)
The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. (1999) (209)
Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors (*) (1995) (208)
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. (2013) (207)
Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. (2000) (203)
Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells. (1985) (200)
Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. (1989) (199)
Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. (1995) (198)
Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells (2007) (194)
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells (2006) (191)
Identification of alpha 2-macroglobulin as a carrier protein for IL-6. (1989) (190)
The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors (2003) (188)
BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. (1994) (182)
Stat3 Controls Cell Movements during Zebrafish Gastrulation. (2002) (181)
Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages (1988) (181)
Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells* (1997) (181)
Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily (1994) (180)
IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells (2005) (180)
Hepatic interleukin-7 expression regulates T cell responses. (2009) (176)
Inflammation amplifier, a new paradigm in cancer biology. (2014) (176)
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies. (1989) (174)
Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures. (1988) (174)
An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT (1997) (173)
ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST‐1 (1994) (173)
A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression (1996) (171)
Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein* (1998) (170)
Age-associated increase in interleukin 6 in MRL/lpr mice. (1991) (168)
[Interleukin-6 and its receptor]. (1991) (158)
Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. (1995) (157)
IL-6 cytokine family and signal transduction: a model of the cytokine system (2004) (155)
Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin‐6 (1997) (154)
Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B. (1993) (154)
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association (1995) (148)
Recombinant human interleukin 6 (B‐cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1) (1988) (147)
Zinc suppresses Th17 development via inhibition of STAT3 activation. (2010) (144)
The Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth (2011) (143)
A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. (1998) (143)
Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. (2002) (142)
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1 (1999) (142)
Production of interleukin-6 by normal human trophoblast. (1990) (142)
Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir (2010) (142)
Tissue-Specific Autoregulation of thestat3 Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells (2001) (135)
Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter (1993) (128)
Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish (2000) (128)
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells. (2005) (127)
Molecular basis of the cell specificity of cytokine action. (2002) (124)
Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4* (1996) (122)
Distribution of interleukin-6 in normal and diseased human kidney. (1991) (121)
Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. (1991) (121)
In vitro immune response of human peripheral lymphocytes. I. The mechanism(s) involved in T cell helper functions in the pokeweed mitogen-induced differentiation and proliferation of B cells. (1977) (119)
Biochemical Characterization of Human ZIP13 Protein (2011) (119)
Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. (1998) (118)
Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes (1989) (118)
Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. (2000) (116)
Zinc finger gene fez‐like functions in the formation of subplate neurons and thalamocortical axons (2004) (116)
Enhanced expression of interleukin-6 in primary human renal cell carcinomas. (1991) (115)
Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling (2003) (112)
Human helper T cell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell-replacing factor- (TRF) like factor(s). (1982) (110)
Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors. (1991) (109)
Engagement of Gab1 and Gab2 in Erythropoietin Signaling* (1999) (108)
Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo. (1988) (106)
Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK (1997) (105)
Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias. (1991) (104)
Zinc Is Required for FcεRI-Mediated Mast Cell Activation1 (2006) (104)
Quantitative analysis of serum IL-6 and its correlation with increased levels of serum IL-2R in HIV-induced diseases. (1990) (104)
Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. (1994) (104)
INTERLEUKINS AND IgA SYNTHESIS (1989) (102)
Interleukin 6 (IL-6) (1990) (100)
Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011) (100)
Urinary levels of IL-6 in patients with active lupus nephritis. (1993) (100)
Studies on the structure and regulation of the human hepatic interleukin-6 receptor. (1990) (99)
Zinc transporter Znt5/Slc30a5 is required for the mast cell–mediated delayed-type allergic reaction but not the immediate-type reaction (2009) (98)
Docking Protein Gab2 Is Phosphorylated by ZAP-70 and Negatively Regulates T Cell Receptor Signaling by Recruitment of Inhibitory Molecules* (2001) (97)
Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines. (1987) (96)
The biology of interleukin-6. (1992) (93)
Structure‐function analysis of human interleukin‐6 (1990) (92)
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scaffolding/Docking Protein Gab1 With Tyrosine Phosphatase SHP2 in Cardiomyocytes (2003) (92)
Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6. (1988) (91)
Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation (2002) (91)
Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors. (1995) (90)
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis (1990) (89)
Gab-Family Adapter Molecules in Signal Transduction of Cytokine and Growth Factor Receptors, and T and B Cell Antigen Receptors (2000) (88)
Interleukin 6 perfusion stimulates reconstitution of the immune and hematopoietic systems after 5-fluorouracil treatment. (1990) (88)
Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line (1998) (86)
Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. (1991) (86)
c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130 (2008) (84)
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2). (1988) (83)
Interleukin-6 (B-cell stimulatory factor 2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3). (1988) (83)
The prognostic significance of urinary interleukin 6 in IgA nephropathy. (1991) (83)
Regulation of dharma/bozozok by the Wnt pathway. (2001) (83)
Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowan I-stimulated B cells. (1984) (83)
SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent I CaL, [Ca2+]i transient, and APD increase in cardiomyocytes. (2007) (82)
Overexpression of neurogenin induces ectopic expression of HuC in zebrafish (1997) (80)
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (2002) (77)
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. (2007) (77)
Disease-association analysis of an inflammation-related feedback loop. (2013) (77)
Synergistic regulatory effects of interleukin 6 and interleukin 1 on the growth and differentiation of human and mouse myeloid leukemic cell lines. (1989) (73)
IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb1 (2006) (73)
Expression of the zinc finger gene fez-like in zebrafish forebrain (2000) (72)
Recombinant interleukin 6 stimulates immature murine megakaryocytes. (1990) (71)
STAT3 Down-regulates the Expression of Cyclin D during Liver Development* (2002) (71)
Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. (1988) (71)
A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish (2002) (70)
Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by human T cell leukemia virus (HTLV) and characterization of human BGDF (BCGF II). (1985) (69)
IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). (1996) (69)
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway (2001) (69)
Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells (2003) (69)
Biological and clinical aspects of (1990) (68)
Tyrosine dephosphorylation of STAT3 in SARS coronavirus‐infected Vero E6 cells (2004) (68)
Regulation of Pim-1 by Hsp90. (2001) (67)
Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. (1998) (66)
Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. (1994) (66)
Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2 (2003) (65)
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response (2007) (65)
Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation. (1989) (65)
TRIF–GEFH1–RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T‐cell activation (2006) (64)
The Biology of Interleukin-6 (Part 1 of 2) (1992) (64)
IL-6 positively regulates Foxp3+CD8+ T cells in vivo. (2010) (63)
Human BST-1 expressed on myeloid cells functions as a receptor molecule. (1996) (63)
BST-1/CD157 regulates the humoral immune responses in vivo. (2000) (61)
Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish (2004) (61)
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. (2007) (60)
Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6. (1992) (59)
The molecular mechanisms of chronic inflammation development (2012) (59)
A Novel Role of the L-Type Calcium Channel α1D Subunit as a Gatekeeper for Intracellular Zinc Signaling: Zinc Wave (2012) (57)
Temporal Expression of Growth Factors Triggered by Epiregulin Regulates Inflammation Development (2015) (56)
IL-6 Amplifier, NF-κB–Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses (2012) (56)
Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma. (1988) (56)
Zinc is required for Fc epsilon RI-mediated mast cell activation. (2006) (55)
High-level expression of human BSF-2/IL-6 cDNA in Escherichia coli using a new type of expression-preparation system. (1988) (54)
The Pathological and Physiological Roles of IL-6 Amplifier Activation (2012) (54)
ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun (*) (1995) (53)
STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension (2004) (53)
In vitro expansion of the murine pluripotent hemopoietic stem cell population in response to interleukin 3 and interleukin 6. Application to bone marrow transplantation. (1989) (53)
Mini ReviewNew IL-6 (gp130) Family Cytokine Members, CLC/NNT1/BSF3 and IL-27 (2004) (52)
Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium. (1989) (50)
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina (2004) (50)
Demonstration of the involvement of interleukin 2 in the differentiation of Staphylococcus aureus Cowan I-stimulated B cells. (1984) (49)
Full Oncogenic Activities of v-Src Are Mediated by Multiple Signaling Pathways (2000) (48)
Molecular basis underlying functional pleiotropy of cytokines and growth factors. (1999) (48)
Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. (1991) (48)
A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model (2015) (47)
Induction of IgG secretion in a human B cell clone with recombinant IL 2. (1985) (47)
A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth* (1999) (47)
Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. (1996) (46)
Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells. (1987) (45)
Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA. (1991) (45)
Association of Stat3-dependent transcriptional activation of p19INK4D with IL-6-induced growth arrest. (1997) (45)
Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. (2008) (45)
GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1. (2000) (45)
Antiviral action of tumor necrosis factor in human fibroblasts is not mediated by B cell stimulatory factor 2/IFN-beta 2, and is inhibited by specific antibodies to IFN-beta. (1988) (45)
Signal Transduction through IL‐6 Receptor: Involvement of Multiple Protein Kinases, Stat Factors, and a Novel H7‐sensitive Pathway a (1995) (44)
Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. (1999) (44)
Induction of IgG production in human B lymphoblastoid cell lines with normal human T cells (1978) (43)
Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1. (1995) (43)
Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. (1996) (41)
Renin–angiotensin system inhibitors and the severity of coronavirus disease 2019 in Kanagawa, Japan: a retrospective cohort study (2020) (41)
E1A repression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes. (1994) (41)
Gab1 Contributes to Cytoskeletal Reorganization and Chemotaxis in Response to Platelet-derived Growth Factor* (2004) (40)
A novel function of Stat1 and Stat3 proteins in erythropoietin-induced erythroid differentiation of a human leukemia cell line. (1998) (40)
Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells. (1994) (40)
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth. (1992) (39)
Continuous perfusion with interleukin 6 (IL-6) enhances production of hematopoietic stem cells (CFU-S). (1989) (39)
Elevated serum interleukin-6 associated with a failure in B cell differentiation in common variable immunodeficiency. (1990) (39)
Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells. (1992) (39)
Human helper T cell factor(s). III. Characterization of B cell differentiation factor I (BCDF I). (1984) (39)
Interleukin 6 and plasma cell neoplasias. (1989) (38)
BSF‐2/IL‐6 does not augment lg secretion but stimulates proliferation in myeloma cells (1989) (38)
Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. (2004) (38)
A Four-Step Model for the IL-6 Amplifier, a Regulator of Chronic Inflammations in Tissue-Specific MHC Class II-Associated Autoimmune Diseases (2011) (38)
Interleukin 6 and its receptor in the immune response and hematopoiesis. (1990) (37)
The in vivo Anti‐tumor Effect of Human Recombinant Interleukin‐6 (1990) (36)
Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function. (2001) (36)
Genomic structure of human BST-1. (1996) (36)
IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. (2013) (35)
Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. (1991) (35)
Asymmetric p38 Activation in Zebrafish (2000) (35)
Molecular biology and immunology of interleukin-6. (1992) (35)
Effects of interleukin-6 on hematopoiesis in bone marrow-transplanted mice. (1989) (35)
Thrombopoietic effects of interleukin-6 in long-term administration in mice. (1993) (34)
Gab2, via PI-3K, Regulates ARF1 in FcεRI-Mediated Granule Translocation and Mast Cell Degranulation (2011) (34)
Correction: The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways (2008) (34)
Signal TransductionThrough Cytokine Receptors (1998) (34)
Revival of the autoantibody model in rheumatoid arthritis (2002) (34)
Human helper T cell factor(s) (ThF). I. Partial purification and characterization. (1981) (34)
Interleukin-6 receptor and signals. (1992) (33)
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor (1994) (33)
Signal Transducers and Activators of Transcription (STATs) (2003) (33)
A multifunctional cytokine (IL-6/BSF-2) and its receptor. (1989) (32)
Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site. (1993) (32)
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR (2015) (32)
Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. (1996) (32)
Soluble Interleukin‐6 Receptor Is Released from Receptor‐bearing Cell Lines in vitro (1992) (31)
Phorbol ester increases the level of interleukin 2 mRNA in mitogen-stimulated human lymphocytes. (1984) (31)
Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway* (2008) (30)
Production of interleukin 6 and its relation to the macrophage differentiation of mouse myeloid leukemia cells (M1) treated with differentiation-inducing factor and 1 alpha,25-dihydroxyvitamin D3. (1989) (30)
Molecular Cloning of the cDNAs for Interleukin‐6/B Cell Stimulatory Factor 2 and Its Receptor a (1989) (30)
Interleukin-6: possible implications in human diseases (1989) (29)
A new interleukin with pleiotropic activities (1988) (29)
Organizer formation and function. (2002) (28)
Signaling through Gp130: toward a general scenario of cytokine action. (1999) (28)
Mechanisms of differential regulation of interleukin‐6 mRNA accumulation by tumor necrosis factor alpha and lymphotoxin during monocytic differentiation (1990) (28)
Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses1 (2002) (28)
In vitro immune response of human peripheral lymphocytes. IV. Specific induction of human suppressor T cells by an antiserum to the T leukemia cell line HSB. (1979) (27)
Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells1 (2004) (27)
IL‐6/BSF2 in Normal and Abnormal Regulation of Immune Responses a (1989) (27)
Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis (2019) (27)
Detection of receptors for murine B cell stimulatory factor 1 (BSF1): presence of functional receptors on CBA/N splenic B cells. (1987) (27)
CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. (2006) (26)
Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins. (1988) (26)
Novel mix-family homeobox genes in zebrafish and their differential regulation. (2000) (26)
In situ expression of messenger RNA of interleukin-1 and interleukin-6 in psoriasis: interleukin-6 involved in formation of psoriatic lesions (2004) (26)
Revisiting the 1986 Molecular Cloning of Interleukin 6 (2014) (25)
Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. (1989) (25)
Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio). (2000) (25)
Cloning of interleukin 2 mRNAs from human tonsils. (1983) (25)
Cell-free-synthesized interleukin-6 (BSF-2/IFN-beta 2) exhibits hepatocyte-stimulating activity. (1988) (24)
Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling (2011) (23)
Transcriptional regulation of the junB promoter in mature B lymphocytes. Activation through a cyclic adenosine 3',5'-monophosphate-like binding site. (1996) (23)
Zinc-binding metallothioneins are key modulators of IL-4 production by basophils. (2015) (23)
Epidermal Growth Factor Signaling Mediated by Grb2 Associated Binder1 Is Required for the Spatiotemporally Regulated Proliferation of Olig2‐Expressing Progenitors in the Embryonic Spinal Cord (2007) (23)
In vitro induction of HLA-restricted cytotoxic T lymphocytes against autologous Epstein-Barr Virus transformed B lymphoblastoid cell line. (1981) (22)
Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial (2015) (22)
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway. (1992) (22)
The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. (2004) (21)
Signal transduction through cytokine receptors. (1998) (20)
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. (2004) (19)
Cytokines as autocrine growth factors in malignancies. (1989) (19)
A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish (2003) (19)
Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. (1990) (19)
Current concepts of B cell modulation. (1989) (18)
Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011) (18)
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor. (1994) (17)
SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene. (2010) (17)
Development of CD4+ Macrophages from Intrathymic T Cell Progenitors Is Induced by Thymic Epithelial Cells1 (2004) (16)
In Vitro Immune Response of Human Peripheral Lymphocytes (1977) (16)
Physicochemical and functional properties of murine B cell-derived B cell growth factor II (WEHI-231-BCGF-II). (1985) (16)
Establishment of Autoantibody‐Producing Cell Lines from Peripheral Blood Lymphocytes of Patients with Systemic Lupus Erythematosus (1980) (15)
Site-directed removal of N-glycosylation sites in BST-1/CD157: effects on molecular and functional heterogeneity. (2001) (15)
Isolation and characterization of a human interleukin 2 gene. (1983) (14)
Interleukin 6 and autoimmunity and plasma cell neoplasias. (1992) (14)
[Axis formation in zebrafish]. (2000) (14)
Site-directed removal of N-glycosylation sites in BST-1/CD157: Effects on molecular and functional heterogeneity (2001) (13)
[Basic and clinical aspects of IL-6]. (1991) (13)
Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells (1991) (13)
Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the Spondylocheiro dysplastic Ehlers-Danlos syndrome (2011) (13)
The role of interleukin 6 in plasmacytomagenesis. (1992) (12)
Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat (2001) (12)
Role of interleukin-1beta in a murine model of otitis media with effusion. (2001) (12)
Cytokines in autoimmune disease and chronic inflammatory proliferative disease. (2002) (12)
Transcriptional regulation of the junB gene in B lymphocytes: role of protein kinase A and a membrane Ig-regulated protein phosphatase. (1997) (11)
IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. (2009) (11)
STAT 3 Is Required for the gp 130-mediated Full Activation of the c-myc Gene (1998) (10)
Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157) (1999) (9)
[IL-6 signal transduction and its physiological roles]. (2012) (9)
Establishment of the ELISA for murine soluble gp130, a signal transducer for the IL-6 family cytokine, and its detection in the ascitic fluids of tumor-bearing mice. (1994) (8)
Grasp a pTyr-peptide by its SOCS. (2006) (8)
TRIF – GEFH 1 – RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD 4 T-cell activation (2013) (8)
Interleukin-6 receptor and a unique mechanism of its signal transduction. (1989) (8)
Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility (2002) (8)
COVID-19: a new virus, but an old cytokine release syndrome (2020) (8)
Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial (2016) (7)
Gab 1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor (2004) (7)
BSF-2/IL-6 functions as a killer helper factor in the induction of cytotoxic T cells (1988) (7)
Interleukin-6 in myeloma/plasmacytoma. (1993) (7)
BSF-2/IL-6 is an autocrine growth factor for human multiple myeloma (1988) (6)
Mast Cell Degranulation RI-Mediated Granule Translocation and ε Gab 2 , via PI-3 K , Regulates ARF 1 in (2011) (6)
Transduction of a murine dominant negative activation transcription factor 1 increases cell surface expression of the class I MHC on a human epidermoid tumor cell line. (2000) (6)
Association of p 72 Tyrosine Kinase With Stat Factors and Its Activation by Interleukin-3 , Interleukin-6 , and Granulocyte Colony-Stimulating Factor (2002) (6)
Differentiation through STAT3 Activation IL-6 Regulates In Vivo Dendritic Cell (2004) (6)
Activation of Stat3 by v-Src is through a Ras-independent pathway. (1998) (6)
Activation of gp 130 Transduces Hypertrophic Signal Through Interaction of Scaffolding / Docking Protein Gab 1 With Tyrosine Phosphatase SHP 2 in Cardiomyocytes (2003) (5)
IL-6 and Inflammatory Diseases (2014) (5)
Delineation of human B cell differentiation: immunological and molecular characterization of human B cell differentiation factor (BSF-2). (1987) (4)
Interleukin 6 (BSF2/IL-6) is an autocrine growth factor for human multiple myelomas. (1988) (4)
Proliferation of Memory CD 8 Cytokine Involved in Homeostatic-Targeted β Evidence of a Novel IL-2 / 15 R (2004) (4)
Interleukin 6 and Its Receptor in Immune Regulation (1989) (4)
A Novel Function of Stat 1 a and Stat 3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line (1998) (4)
Molecular structure and immunological function of human B cell differentiation factor (BSF2) (1987) (3)
Regulation of Human B Cell Differentiation: Molecular Structure and Immunological Functions of Human B Cell Differentiation Factor (BSF-2) (1986) (3)
Activation of Stat3 by v-Src Is through a Ras-Independent Pathway (1998) (3)
STATs in Cell Mobility and Polarity during Morphogenetic Movement (2003) (3)
Characterization of growth inhibitory factors for mouse monocytic leukemia cells. (1992) (3)
V‐ABL does not abolish IL‐6 requirement by murine plasmacytoma cells (1991) (3)
Mediated Release of Human Chorionic Gonadotropin by Choriocarcinoma Cell Lines (Jar and HCCM-5) Activates Adenosine 3',5'-Monophosphate-Independent Signal (1992) (3)
Translation of Human Interleukin 2 mRNA in Xenopus laevis Oocytes (1983) (3)
Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157). (1999) (2)
Both Stat 3-Activation and Stat 3-Independent BCL 2 Downregulation Are Important for Interleukin-6 – Induced Apoptosis of 1 A 9M Cells (1999) (2)
Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling (2015) (2)
Molecular structure of interleukin 6 receptor. (1988) (2)
B Cell Stimulatory Factor 2 (BSF2/IL-6) and Rheumatoid Arthritis (1987) (2)
Regulation of human IgA and IgA subclass synthesis by recombinant interleukin-6 (1990) (2)
gp130-mediated signalling as a therapeutic target (2000) (2)
[Cytokines and diseases. Abnormal expression of interleukin 6 and diseases]. (1991) (2)
In fl ammation Ampli fi er , a New Paradigm in Cancer Biology (2013) (2)
Regulation of growth and differentiation of human B cells (1985) (2)
[Role of zinc/zinc transporter in allergic response]. (2010) (2)
Reviews of Physiology, Biochemistry and Pharmacology (2003) (1)
[Cytokines and receptors--their functions, structures and cloning of code genes. Functional polymorphism of BSF-2/IL-6 and its abnormal expression]. (1988) (1)
Interleukin 6 and its Receptor: TenYears Later (1998) (1)
Constitutive production of b cell stimulatory factor 2 bsf 2 il 6 in rheumatoid arthritis (1988) (1)
[IL-6 receptor and signal transduction pathway]. (1991) (1)
THU0174 ANTI-IL-6 RECEPTOR ANTIBODY AMELIORATES DISEASE ACTIVITY OF RHEUMATOID ARTHRITIS PATIENTS WITH KNEE JOINT INVOLVEMENT -ANSWER COHORT STUDY- (2020) (1)
Mucosal TD Antigen-Elicited IgA Thymus Independent-2 Antigen-Induced IgG 3 Antigen-1 ( CD 157 ) Gene Impaired Systemic Deletion of Bone Marrow Stromal Cell (1998) (1)
HIV‐induced B Cell Stimulatory Factor 2/Interleukin‐6 (BSF2/IL6) Production a (1989) (1)
Abstract 17707: Gab1 Attenuates Angiotensin II-accelerated Atherosclerosis in Apolipoprotein E Deficient Mice via HGF/c-Met Signaling Pathway (2010) (1)
[Interleukin 6 and disease]. (1991) (1)
Thymus-Independent Antigen-2 Responses Cells and Negatively Regulates Is Specifically Expressed in Marginal Zone B Adapter Molecule Grb 2-Associated Binder 1 (2002) (1)
Molecular Regulation of the Human Immunoglobulin γ1 Heavy Chain Gene by IL‐6 (1989) (1)
Cellular and Molecular Mechanisms of Human B-Lymphocyte Differentiation (1987) (1)
[Evaluation of time dependency of the acetazolamide effect on cerebral hemodynamics as measured by 99mTc-ECD single-photon emission computed tomography]. (2001) (1)
Enhancement of experimental metastasis by gamma-interferon in a murine adenocarcinoma. (1996) (1)
[Left ventricular relaxation in lone atrial fibrillation and atrial fibrillation with heart disease]. (1999) (1)
Mechanisms and Biological Roles of STAT Activation by the IL-6 Family of Cytokines (2003) (1)
Role for interleukins 5 and 6 in IgA synthesis (1990) (1)
Expression of mature human interleukin 2 and its derivatives in Escherichia coli and comparison of their biological activity in vitro (1987) (1)
“Blockage of interleukin-6 Receptor Ameliorates Joint Disease in Murine Collagen-Induced Arthritis.” Arthritis (2017) (1)
Characterization of ZIP 13 protein 1 Biochemical characterization of human ZIP 13 protein : a homo-dimerized zinc transporter involved in the Spondylocheiro dysplastic Ehlers-Danlos syndrome (2011) (1)
Interleukin 6 and its receptor: A cytokine acting in the nervous system (1989) (0)
Activation of multiple protein kinases, Stat factors and a H7-sensitive pathway by GP130-stimulation (1994) (0)
Abnormal production of interleukin 6 and B cell anomaly. (1988) (0)
Role of CD157 in the regulation of chemotaxis by human granulocytes (2003) (0)
Abstract 5439: Scaffolding Docking Protein Gab1 Is Essential for HGF-Mediated Endothelial Signaling and Angiogenesis after Hind-Limb Ischemia (2008) (0)
Cell-Mediated Immune Response in Vitro (1976) (0)
Abstract 5803: Interaction of Docking Protein Gab1 With Tyrosine Phosphatase SHP2 Regulates Hepatocyte Growth Factor-dependent ERK5 Activation and Upregulation of KLF2 in the Vascular Endothelium (2009) (0)
Crystal Structure Analysis of BST-1/CD157 (2002) (0)
Targeted Disruption of Gab1 Gene Leads to Developmental Abnormalities in Heart (2003) (0)
Intrathymic T Cell Progenitors Is Induced by Macrophages from + Development of CD 4 Shigeo Koyasu and Atsushi Miyajima (2004) (0)
[Role of zinc for mast cell degranulation]. (2008) (0)
Rheumatoid arthritis and other inflammatory joint diseases (animal models) (PP-037) (2010) (0)
[IL-6 and IL-6 receptor]. (1990) (0)
Th17 (PP-014) (2010) (0)
[Normal and abnormal regulation of human T lymphocytes in immune response (author's transl)]. (1978) (0)
Anticorps monoclonal contre le bcdf humain (1988) (0)
Agents favorisant la thérapie contre le cancer (1990) (0)
Author response: A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model (2015) (0)
A gene encoding a polypeptide that is capable of growth pre-B cell support. (1994) (0)
[B-cell stimulating factor, BSF-2 and autoimmune diseases]. (1988) (0)
Role of STAT3 in differentiation of fetal hepatic cells induced by mouse oncostatinM (1998) (0)
Triggered by Epiregulin Regulates Temporal Expression of Growth Factors (2014) (0)
The immunobiology of interleukin 6 (IL-6) and its receptor (1990) (0)
Crystal Structure Analysis of BST-1/CD157 with ATPgammaS (2002) (0)
Monoclonal antibody to human BCDF. (1988) (0)
Human recombinant BSF-2/IL-6 augments murine antigen-specific antibody responses in vitro and in vivo (1988) (0)
Cytokines: edited by M.J. Clemens, Bios Scientific Publishers, 1991. £11.95 (ix + 121 pages) ISBN 1 8727 470 8 (1992) (0)
Differentiation andgrowtharrest signals are generated through thecytoplasmic region ofgp130 thatisessential forStat3activation (1996) (0)
Crystal Structure Analysis of BST-1/CD157 complexed with ethenoNADP (2002) (0)
Immunity to bacterial infection (excluding mycobacteria) (WS-060) Chairpersons: Masao Mitsuyama, Seppo Meri (2010) (0)
[gp130F759 mouse]. (2005) (0)
Interleukin 6 and its Receptor: Pathological Role in Autoimmunity and Lymphoid Malignancy (1989) (0)
encoding a polypeptide which has the ability to support the gene pre-B cell proliferation (1994) (0)
stimulated production of platelets In vivo effects of recombinant human interleukin-6 in primates: (2011) (0)
Pim-1 and c-Myc transmit STAT3-mediated signals for cell cycle progression and antiapoptosis (2000) (0)
OJ-523 Skeletal Alpha-actin Gene Expression Is Negatively Regulated by Protein Tyrosine Phosphatase SHP2 Through Inhibition of Rho signaling Pathway in Cardiomyocytes(Molecular Biology, Myocardium 2 (M) : OJ64)(Oral Presentation (Japanese)) (2004) (0)
Correction (2005) (0)
Crystal Structure Analysis of BST-1/CD157 complexed with NMN (2002) (0)
Responsesand Mucosal TD Antigen-Elicited IgA Thymus Independent-2 Antigen-Induced IgG3 Antigen-1 (CD157) Gene Impaired Systemic Deletion of Bone Marrow Stromal Cell (1998) (0)
Correction: IL-6 Amplifier, NF-κB-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses (2012) (0)
The polypeptide of a membrane proteins having the function to support the growth of pre-B cells and his gen (1994) (0)
Erratum (2009) (0)
Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells (2005) (0)
Regulation of human B lymphocytes differentiation: Characterization of B cell stimulatory factors (1985) (0)
Facteur de différenciation recombinant de cellule B (1987) (0)
[Clinical significance of interleukin-6 assay]. (1990) (0)
Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis (2019) (0)
lymphoma-derived T-cell line ( KT-3 ) Interleukin-6 ( B-cell stimulatory factor 2 )-dependent growth of a Lennert ' s (2005) (0)
Anti-inflammatory gp 130-mediated signalling as a therapeutic target (2000) (0)
Survival Signals in T Cells Gene and Its Role in Interleukin-6-Induced stat 3 Tissue-Specific Autoregulation of the (2001) (0)
Cytokine Involved in Homeostatic -Targeted β Evidence of a Novel IL-2/15R (2017) (0)
Ionizing radiation induces IL-6-production by human fibroblasts involving activation of nuclear factor-. kappa. B (1992) (0)
IgE-mediated allergic responses (WS-021) Chairpersons: Keigo Nishida, Yoshiyuki Minegishi (2010) (0)
A role of Gab family in cytokine signal transduction (1998) (0)
T cell homeostasis and memory (PP-059) (2010) (0)
T cell homeostasis and memory (WS-059) Chairpersons: Masaaki Murakami, Naoto Ishii (2010) (0)
Rheumatoid arthritis and other inflammatory joint diseases (animal models) (WS-037) Chairpersons: Hitoshi Kohsaka, Marianna Newkirk (2010) (0)
Gab Family Docking Proteins are Essential for Prevention of Dilated Cardiomyopathy through Transmitting Neuregulin-ErbB Signaling (2006) (0)
Involved in Allogeneic Rejection Responses Feedback for IL-6 Signaling, in Grafts Is Triggered Positive - B κ IL-6 Amplifier, NF- (2012) (0)
Regulatory T cells and autoimmunity (PP-073) (2010) (0)
Inflammation / Cytokines (SY3-5) Chairpersons: Toshio Hirano, Anne O'Garra (2010) (0)
SHP2-mediated signaling cascade through gp130 is essential for LIF- and IL6-dependent ICaL increase in mouse (2005) (0)
Abstract 137: Gab Family Scaffolding Adaptor Proteins are Essential for Postnatal Maintenance of Cardiac Function via Neuregulin-1/ErbB Signaling (2007) (0)
Molecular Structure o f Interleukin 6 Receptort (2006) (0)
to support gene coding for a polypeptide which has the ability to pre-B cell proliferation (1994) (0)
encodes a polypeptide which has the ability to allow a gene of the pre-B cell growth (1994) (0)
OP0152 A longitudinal study of the effects of disease activity on renal function in patients with rheumatoid arthritis utilizing linear mixed effect models - answer cohort study - (2017) (0)
Scaffolding / Docking Protein Gab 1 With Tyrosine Phosphatase SHP 2 in Cardiomyocytes Activation of gp 130 Transduces Hypertrophic Signal Through Interaction of (2003) (0)
THU0107 OBESITY PREDICTS RESPONSE TO NOT ALL BUT CERTAIN BIOLOGICAL / TARGETED DISEASE MODIFYING ANTI-RHEUMATIC DRUGS FOR RHEUMATOID ARTHRITIS - RESULTS FROM KANSAI CONSORTIUM FOR WELL-BEING OF RHEUMATIC DISEASE PATIENTS (ANSWER COHORT) (2020) (0)
INDUCTION IN RAT HEPATOCYTES HEPATOMA-CELLS OF THE ACUTE PHASE RESPONSE - EFFECTS OF DIFFERENT MEDIATORS (1987) (0)
[Pleiotropic functions of BSF-2/IL-6]. (1988) (0)
Interleukin 6 receptor-mediated signal transduction pathways (1994) (0)
S3e1-5 Zinc signaling in epithelial-mesenchymal transition during gastrulation, wound healing, and cancer progression(S3-e1: "Dynamic Features in Immune System",Symposia,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
How COVID-19 induces cytokine storm with high mortality (2020) (0)
Peripheral Blood Stem Cells Harvest in Patients with Hematologic Malignancies : Using COBE Spectra(Hematological Disease,General Presentation,Proceedings of the Thirteenth Annual Meeting of Japanese Society for Apheresis) (1994) (0)
The Biology of Interleukin-6 (Part 2 of 2) (1992) (0)
Tumor immunity and immunosurveillance (PP-093) (2010) (0)
Molecular cloning of the cDNA encoding human B cell stimulatory factor 2 receptor (BSF-2/IL-6R) (1988) (0)
Lymphokines and Monokines (I) (1989) (0)
COSTIMULANT FORHUMANTHYMOCYTES AND TLYMPHOCYTES (1988) (0)
Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production ( B-cell stimulatory factor 2 / NH 2-terminal sequence / cardiac myxoma / autoimmunity ) (0)
Recombinant interleukin-6 enhances specific antibody secretion by in vivo activated human B cells (1990) (0)
Crystal Structure Analysis of BST-1/CD157 complexed with nicotinamide (2002) (0)
B cell stimulatory factor 2 (BSF-2/IL-6) and rheumatoid arthritis (1988) (0)

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