Tsutomu Shimada
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Computer Science
Tsutomu Shimada's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Tsutomu Shimada's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. (1994) (2898)
- Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. (1991) (1037)
- Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. (1996) (832)
- Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1 (2004) (708)
- Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. (2006) (565)
- Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. (1992) (380)
- Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. (1989) (321)
- Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. (1997) (306)
- Activation and detoxication of aflatoxin B1. (1998) (299)
- Catalytic properties of polymorphic human cytochrome P450 1B1 variants. (1999) (292)
- Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. (1989) (285)
- Purification and characterization of human liver microsomal cytochrome P-450 2A6. (1991) (273)
- Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs. (1996) (267)
- Activation of procarcinogens by human cytochrome P450 enzymes. (1998) (266)
- Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. (1992) (256)
- SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. (1987) (251)
- Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes (1999) (247)
- Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. (2002) (245)
- Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. (1986) (241)
- Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. (1989) (233)
- Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. (2002) (232)
- Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. (2001) (219)
- Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. (1990) (205)
- Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. (1998) (203)
- Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. (1995) (201)
- Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4 (1996) (195)
- Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. (2000) (192)
- Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. (1998) (188)
- Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. (2006) (185)
- Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. (1998) (174)
- Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. (1997) (171)
- Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans (1997) (163)
- Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies. (2003) (156)
- Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. (1999) (155)
- Newborn screening and diagnosis of mucopolysaccharidoses. (2013) (148)
- Molecular Cloning of a Novel Human Collectin from Liver (CL-L1)* (1999) (146)
- Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. (1990) (146)
- Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations. (1997) (142)
- Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. (2008) (137)
- Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations. (1996) (136)
- Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. (1997) (133)
- Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. (1997) (133)
- Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2* (2005) (132)
- Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. (2003) (132)
- Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. (1996) (131)
- Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes (1996) (129)
- Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates. (1995) (129)
- Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity. (1992) (125)
- Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. (1994) (121)
- Characterization of cytochrome P-450 2B6 in human liver microsomes. (1993) (118)
- Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers. (1997) (116)
- Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1 (2006) (114)
- Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. (1992) (114)
- Synaptic Vesicle Ultrastructural Changes in the Rat Hippocampus Induced by a Combination of α‐Linolenate Deficiency and a Learning Task (1997) (114)
- Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase. (1999) (109)
- 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. (1996) (108)
- Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. (2010) (107)
- Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. (2001) (103)
- Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. (1994) (103)
- Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. (1999) (101)
- In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. (1996) (100)
- Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. (2001) (100)
- Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues (1999) (99)
- Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. (1992) (96)
- Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity. (1995) (95)
- Recombinant human cytochrome P450 1B1 expression in Escherichia coli. (1998) (94)
- Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells. (2011) (91)
- Specific profile of liver microsomal cytochrome P-450 in Dolphin and Whales (1989) (90)
- Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences (2006) (87)
- Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). (1992) (85)
- Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. (1999) (83)
- Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice (2011) (81)
- Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes. (1997) (81)
- Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. (2002) (80)
- Specificity of 17β-oestradiol and benzo[α]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432 (2001) (78)
- Electron Transport Pathway for a Streptomyces Cytochrome P450 (2007) (76)
- Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O‐acetyltransferase and nitroreductase activities (1993) (75)
- Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation. (1986) (75)
- Mutagenic effects of cadmium on mammalian oocyte chromosomes. (1979) (75)
- Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-Glycoprotein after high-dose steroid therapy (2002) (75)
- Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. (1999) (74)
- Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002. (1987) (74)
- Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. (2005) (73)
- Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). (2003) (73)
- Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. (1994) (73)
- Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. (1994) (73)
- Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs. (1998) (71)
- Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder. (2013) (71)
- Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. (2001) (70)
- Activation of Amino-α-carboline, 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine, and a Copper Phthalocyanine Cellulose Extract of Cigarette Smoke Condensate by Cytochrome P-450 Enzymes in Rat and Human Liver Microsomes (1991) (69)
- Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization (1992) (69)
- Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes. (1995) (68)
- Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice. (2009) (67)
- Genotoxic and mutagenic activation of aflatoxin B1 by constitutive forms of cytochrome P-450 in rat liver microsomes. (1987) (67)
- Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. (1996) (67)
- Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. (1989) (66)
- Establishment of Glycosaminoglycan Assays for Mucopolysaccharidoses (2014) (62)
- CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. (2013) (62)
- Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. (1998) (61)
- Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors. (2007) (61)
- Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome (2015) (61)
- Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes. (1998) (58)
- Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification. (1996) (57)
- Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. (1997) (57)
- Activation of 3,4,3',4'-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system. (1983) (57)
- Metabolic activation of environmental carcinogens and mutagens by human liver microsomes. Role of cytochrome P-450 homologous to a 3-methylcholanthrene-inducible isozyme in rat liver. (1988) (56)
- Impact of enzyme replacement therapy and hematopoietic stem cell therapy on growth in patients with Hunter syndrome (2014) (56)
- CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians (2000) (56)
- Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7 alpha- and coumarin 7-hydroxylations. (1994) (54)
- Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. (2001) (54)
- Morquio A syndrome: diagnosis and current and future therapies. (2014) (53)
- Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology. (1992) (50)
- Preventive effects of Bofutsushosan on obesity and various metabolic disorders. (2008) (50)
- Pharmacokinetic advantage of intraperitoneal injection of docetaxel in the treatment for peritoneal dissemination of cancer in mice (2005) (50)
- Effect of intraperitoneal administration of docetaxel on peritoneal dissemination of gastric cancer. (2004) (49)
- Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives. (1990) (48)
- Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes. (1996) (48)
- Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. (2002) (48)
- Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase. (1997) (47)
- A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system. (1996) (46)
- Potential mutagenicity of cadmium in mammalian oocytes. (1976) (45)
- Enzyme replacement therapy for treating mucopolysaccharidosis type IVA (Morquio A syndrome): effect and limitations (2015) (45)
- Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. (2014) (45)
- Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolism. (2003) (44)
- Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases. (2011) (43)
- Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. (2013) (42)
- Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. (1997) (42)
- Assay for Glycosaminoglycans by Tandem Mass Spectrometry and its Applications (2014) (42)
- Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. (2009) (40)
- Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice (2003) (40)
- Skin fragility in obese diabetic mice: possible involvement of elevated oxidative stress and upregulation of matrix metalloproteinases (2012) (40)
- Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. (1990) (40)
- Insulin resistance and low sympathetic nerve activity in the Tsumura Suzuki obese diabetic mouse: a new model of spontaneous type 2 diabetes mellitus and obesity. (2006) (40)
- Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity (2017) (39)
- Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. (1995) (39)
- Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians. (2002) (38)
- Chondroitin 6-Sulfate as a Novel Biomarker for Mucopolysaccharidosis IVA and VII. (2015) (38)
- The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury. (2012) (37)
- Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation. (2012) (37)
- Growth charts for patients with Hunter syndrome (2014) (37)
- Participation of a rat liver cytochrome P-450 induced by pregnenolone 16 alpha-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin. (1985) (37)
- Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular carcinoma in a mouse model of metabolic syndrome (2013) (37)
- Iron twin-coronet porphyrins as models of myoglobin and hemoglobin: amphibious electrostatic effects of overhanging hydroxyl groups for successful CO/O2 discrimination. (2003) (36)
- Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome. (2011) (36)
- Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. (1993) (35)
- Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I) (2010) (35)
- Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats. (2007) (34)
- Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. (2008) (34)
- A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM1011 having a high nitroreductase activity. (1992) (34)
- Di-sulfated Keratan Sulfate as a Novel Biomarker for Mucopolysaccharidosis II, IVA, and IVB. (2015) (34)
- Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity (2009) (34)
- Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). (1992) (34)
- Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. (1999) (33)
- Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes (2001) (33)
- Covalent binding of polychlorinated biphenyls to rat liver microsomes in vitro: nature of reactive metabolites and target macromolecules. (1980) (33)
- The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. (1998) (33)
- Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes. (2002) (33)
- Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. (1996) (32)
- Species differences in the metabolism of (+)- and (-)-limonenes and their metabolites, carveols and carvones, by cytochrome P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humans. (2002) (32)
- Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. (2013) (32)
- Novel heparan sulfate assay by using automated high-throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses. (2014) (31)
- Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. (2012) (31)
- Therapies of mucopolysaccharidosis IVA (Morquio A syndrome) (2013) (30)
- Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002. (1999) (30)
- Long-term levothyroxine treatment decreases the oral bioavailability of cyclosporin A by inducing P-glycoprotein in small intestine. (2005) (30)
- Aging‐like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling (2013) (30)
- Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal Model of Metabolic Syndrome (2012) (30)
- Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: early treatment rescues bone lesions? (2014) (29)
- Effects of roxithromycin, erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome P450 enzymes. (1996) (28)
- Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice (2012) (27)
- Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes. (2011) (27)
- Mutagenic activation of aflatoxin B1 by pulmonary, renal, and hepatic cytochrome P450s from rats. (1992) (27)
- Understanding electron transport systems of Streptomyces cytochrome P450. (2006) (26)
- Cytochrome P-450 forms and its inducibility by PCB isomers in black-headed gulls and black-tailed gulls (1992) (26)
- Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. (2011) (26)
- Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. (2003) (25)
- Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity. (1994) (25)
- Activity of daily living for Morquio A syndrome. (2016) (24)
- Activation of carcinogens by human liver cytochromes P-450. (1990) (24)
- Cytochrome P450 reconstitution systems. (1998) (24)
- Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. (1999) (24)
- Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. (1992) (24)
- Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus (2011) (23)
- Newborn screening and diagnosis of mucopolysaccharidoses: application of tandem mass spectrometry. (2014) (23)
- Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis (2011) (23)
- Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450. (1981) (23)
- Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. (2000) (22)
- Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes. (1992) (22)
- Differential roles of cytochromes P450 2D1, 2C11, and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes. (1994) (21)
- A dietary restriction influences the progression but not the initiation of MSG-Induced nonalcoholic steatohepatitis. (2014) (21)
- Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH‐cytochrome P450 reductase and bacterial O‐acetyltransferase in SOS/umu assay (2000) (20)
- Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: Clinical, biochemical, and pathological improvements (2015) (20)
- Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 (1994) (20)
- Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor κB ligand-induced osteoclast differentiation. (2012) (20)
- Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13 (2016) (19)
- Roles of CYP 2 A 6 and CYP 2 B 6 in nicotine C-oxidation by human liver microsomes (19)
- Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice. (2006) (19)
- Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes. (1996) (18)
- Docking and QSAR comparative studies of polycyclic aromatic hydrocarbons and other procarcinogen interactions with cytochromes P450 1A1 and 1B1 (2012) (18)
- Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. (2016) (18)
- Disposition Kinetics of Taxanes in Peritoneal Dissemination (2012) (18)
- Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata (2010) (18)
- Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes. (1979) (17)
- Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes. (1991) (17)
- Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl (2016) (17)
- Gallic Acid, the Active Ingredient of Terminalia bellirica, Enhances Adipocyte Differentiation and Adiponectin Secretion. (2016) (17)
- Long-term case study of myelodysplastic syndrome in a dog. (1999) (17)
- The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism (1994) (16)
- Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue (2015) (16)
- A convenient assay for mephenytoin 4-hydroxylase activity of human liver microsomal cytochrome P-450. (1985) (16)
- Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis IVA (2015) (16)
- Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice (2011) (16)
- Procarcinogens by Cytochromes P 450 1 a 1 and P 450 1 B 1 Allelic Variants and Other Human Cytochromes P 450 in Salmonella Typhimurium Nm 2009 (2001) (15)
- Salacia reticulata has therapeutic effects on obesity (2014) (15)
- Involvement of α1‐acid glycoprotein in inter‐individual variation of disposition kinetics of ropivacaine following epidural infusion in off‐pump coronary artery bypass grafting (2007) (15)
- Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene (2000) (15)
- Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora (2014) (15)
- Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. (2015) (14)
- Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies (2018) (14)
- Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone. (2006) (14)
- Cremophor EL releases cyclosporin A adsorbed on blood cells and blood vessels, and increases apparent plasma concentration of cyclosporin A. (2005) (14)
- Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. (2006) (14)
- Noninvasive identification of bladder cancer with subsurface backscattered light (1994) (14)
- Effect of Kaempferia parviflora extract on knee osteoarthritis (2017) (13)
- Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants (2018) (13)
- Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B (2008) (13)
- Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1. (1996) (13)
- The Crude Extract from Puerariae Flower Exerts Antiobesity and Antifatty Liver Effects in High-Fat Diet-Induced Obese Mice (2012) (13)
- Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. (1991) (13)
- Enzyme replacement therapy on hypophosphatasia mouse model (2014) (13)
- Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. (1994) (12)
- Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone (2019) (12)
- Non-invasive pulmonary function test on Morquio patients. (2015) (12)
- Mechanisms of Enhancement and Inhibition of Cytochrome-P450 Catalytic Activities (1994) (12)
- Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. (1991) (12)
- Effects of Green Tea Fractions on Oxygen-Induced Retinal Neovascularization in the Neonatal Rat (2007) (11)
- Efficacy of Tokishakuyakusan on the anemia in the iron-deficient pregnant rats. (2007) (11)
- A study of cardiovascular function in Tsumura Suzuki obese diabetes, a new model mouse of type 2 diabetes. (2010) (11)
- Optical diagnostics based on elastic scattering: recent clinical demonstrations with the Los Alamos optical biopsy system (1994) (10)
- Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. (2019) (10)
- Comparative studies on distribution and covalent tissue binding of 2,4,2′,4′- and 3,4,3′,4′-tetrachlorobiphenyl isomers in the rat (1984) (10)
- N-oxidation of irsogladine by the CYP2C subfamily in the rat, dog, monkey and man. (1997) (10)
- Possible occurrence of P450 related to P450 HFLb in extrahepatic tissues of human fetuses and its contribution to metabolic activation of promutagens. (1994) (10)
- Cytochrome P450 reconstitution systems. (2006) (9)
- Covalent binding in vitro of polychlorinated biphenyls to microsomal macromolecules. Involvement of metabolic activation by a cytochrome P-450-linked mono-oxygenase system. (1978) (9)
- Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes (2018) (9)
- Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus (2015) (8)
- Purification and characterization of acidic form of glutathione S-transferase in human fetal livers: high similarity to placental form. (1991) (8)
- Effect of oleic acid on mitochondrial oxidative phosphorylation in rat brain slices. (1988) (7)
- Interaction of 3,4,3′,4′-tetrachlorobiphenyl metabolites formed by cytochrome P-450 in vitro with rat erythrocytes (1985) (7)
- Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rats (2017) (7)
- Involvement of alpha1-acid glycoprotein in inter-individual variation of disposition kinetics of ropivacaine following epidural infusion in off-pump coronary artery bypass grafting. (2007) (7)
- Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes. (1990) (7)
- [Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer]. (2005) (7)
- Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes (2020) (6)
- Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice (2012) (6)
- Structure and function of cytochrome P-450. (1986) (6)
- Oxidation and conjugation of aflatoxins by humans and experimental animals. (1992) (6)
- ポリ塩化ビフェニール(PCB)によるマウス，ラット肝ミクロゾーム酵素誘導と組織中PCB量の関連について (1976) (6)
- Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes. (1998) (6)
- Activation of mutagens by human cytochrome P-450 enzymes. (1990) (6)
- Preventive effects of Daisaikoto on metabolic disorders in spontaneous obese type II diabetes mice (2006) (6)
- Structure − Function Studies of Naphthalene , Phenanthrene , Biphenyl , and Their Derivatives in Interaction with and Oxidation by Cytochromes P 450 2 A 13 and 2 A 6 (2016) (5)
- Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. (2002) (5)
- Stimulation of Cytochrome P450 Reactions by Apo-cytochromeb 5 (2001) (5)
- In vitro degradation of trans-chlordane and oxychlordane by rat liver microsomes (1989) (5)
- Lack of correlation between formation of reactive metabolites and thymic atrophy caused by 3, 4, 3′, 4′-tetrachlorobiphenyl in C57BL/6N mice (1987) (5)
- Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol (2013) (4)
- Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer (2020) (4)
- Aflatoxin B1 oxidation by human cytochrome P450s. (1998) (4)
- The formation of azoxy-2-phenylethane during the biological oxidation of phenylethylamine by rabbit liver microsomes. (1981) (3)
- Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study (2017) (3)
- PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration (2015) (3)
- Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase 4 isoenzyme. (2006) (3)
- Activation of 6-aminochrysene to genotoxic products by different forms of rat liver cytochrome P450 in an O-acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). (1992) (3)
- Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods (2018) (3)
- Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy (2020) (3)
- High-performance liquid chromatographic method for the determination of (-)-verbenone 10-hydroxylation catalyzed by rat liver microsomes. (2003) (3)
- Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes (2020) (3)
- A Sensitive System (umu Test) for the Detection of Mutagenic Nitroarenes in Salmonella Typhimurium Strain Possessing Elevated Nitroreductase (1992) (3)
- Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma (2020) (3)
- An Autopsy Case of Amaurotic Family Idiocy (1957) (3)
- Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study (2019) (2)
- O I.4 Roles of human cytochrome P450s 1A1, 1A2, 1B1, 2E1, and 3A4/5/7 in the activation of environmental procarcinogens and promutagens (1997) (2)
- A frequent DHFR polymorphism detected by an intron fragment. (1989) (2)
- Studies on Absorption, Distribution and Excretion of Phthalates (1977) (2)
- Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis (2017) (2)
- 3A-02 Effects of co-administration of food antioxidants and naturally occurring components, flavonoids on the activation of mutagens (1997) (2)
- Influence of cytarabine and cyclophosphamide on the disposition kinetics of cyclosporin A after bone marrow transplantation (2003) (2)
- [Recovery from toxicological and biochemical effects of rats intoxicated with polychlorinated biphenyls (author's transl)]. (1977) (2)
- Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat (2018) (2)
- Aggregation in a Suspension of Lansoprazole OD Tablets and Levofloxacin Hydrate Tablets in Water (2017) (2)
- Lipid composition of the plasma membrane isolated from normal and precancerous rat bladder epithelium (2004) (1)
- Comparison of rates of enzymic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses [Erratum to document cited in CA110(23):207559z] (1989) (1)
- Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment. (2021) (1)
- Palonosetron on Days 1 and 5 Versus Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy (2019) (1)
- Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections (1994) (1)
- Roles of Human CYP 2 A 6 and Monkey CYP 2 A 24 and 2 A 26 Cytochrome P 450 Enzymes in the Oxidation of 2 , 5 , 2 ́ , 5 ́Tetrachlorobiphenyl ́Tetrachlorobiphenyl ́Tetrachlorobiphenyl (2016) (1)
- Influence of cytarabine and cyclophosphamide on the disposition kinetics of cyclosporin A after bone marrow transplantation (2003) (1)
- ROLES OF HUMAN CYP 2 A 6 AND 2 B 6 AND RAT CYP 2 C 11 AND 2 B 1 IN THE 10-HYDROXYLATION OF ( )-VERBENONE BY LIVER MICROSOMES (2003) (1)
- Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes (2021) (1)
- Analysis of C6S/C4S ratio in Morquio syndrome type A patients (2015) (1)
- Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. (2020) (1)
- Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice (2011) (1)
- Interindividual Variations in Xenobiotic-Oxidizing P450 Activities in Humans. (2000) (1)
- Comparison of reconstitution conditions for recombinant human P450 2C9 with systems containing P450S 1A1, 1A2, 2D6, 2E1, and 3A4. Effects of P450-P450 and P450-b(5) interactions (1997) (1)
- Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model (2021) (1)
- The active ingredients in the anti‐obesity drug bofutsushosan in high‐fat‐diet‐fed obese mice (2020) (1)
- Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study (2019) (1)
- Effects of DI-(2-ethylhexyl) phthalate on the content and composition of hepatic mitochondrial and microsomal phospholipids in the rat. (1979) (1)
- [Induction of mouse and rat liver microsomal enzymes by polychlorinated biphenyls and its relations to the PCB levels in the tissue]. (1976) (0)
- Metabolic activation of [14C]polychlorinated hinhmvlE by rat liver microsomes (1976) (0)
- [The effect of theanine on oxygen-induced retinal neovascularization in the neonatal rat]. (2004) (0)
- A sensitive umu test system for detecting genotoxicity of mutagenic dihaloalkanes using Salmonella typhimurium tester strain expressing rat glutathione S-transferase (1996) (0)
- METABOLIC ACTIVATION OF 3-METHOXY-4-AMINOAZOBENZENE BY LIVER MICROSOMES : CONTRIBUTION OF DIFFERENT FORMS OF RAT AND HUMAN CYTOCHROME P-450 ENZYMES IN THE REACTION (1991) (0)
- RELATIONSHIPS BETWEEN GENETIC POLYMORPHISMS IN CYP2D6 AND CYP2E1 GENES AND LIVER MICROSOMAL DRUG OXIDATION ACTIVITIES (2000) (0)
- Binding Disposition of Local Anesthetic Ropivacaine to .ALPHA.1 -acid Glycoprotein and Interactions with Co-administered Drugs (2005) (0)
- Roles of rat and human epoxide hydrolase inhydrolysis of aflatoxin B_1 8, 9-epoxide (1998) (0)
- Classification of superficial lesions of the eye with an optical biopsy system: First trials with the Los Alamos instrument (1993) (0)
- Noninvasive pulmonary function test on Morquio syndrome type A patients (2015) (0)
- Evidence for cytochrome P45 ONF , the nifedipine oxidase , being the principal enzyme involved in the bioactivation of aflatoxins in human liver ( mutagenicity / drug metabolism / chemical carcinogens ) (0)
- Expressed P450s in toxicity assays (2001) (0)
- O-16 Detection of CarcinogenicAromatic Amines Using Umu Tester Strains Endogenously Expressing Human Cytochrome P450 1A2 and NADH-P450 Reductase, and/or Bacterial O-Acetyltransferase.(Proceedings of the 27th Annual Meeting) (2000) (0)
- Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression. (2020) (0)
- Use of recombinant human P450 enzymes in the studies of drug metabolism and chemical carcinogenesis (2000) (0)
- L-Theanine Suppresses Lipid Hydroperoxide-Induced Rabbit Corneal Neovascuralization (2007) (0)
- Title Disposition kinetics of taxanes in peritoneal dissemination (2017) (0)
- Title Obesity-induced increase of CYP 2 E 1 activity and its effect on dispositionkinetics of chlorzoxazone in Zucker rats (2017) (0)
- Pharmacokinetics of fentanyl after dermal administration to arthritis model rats (2018) (0)
- MUTAGENIC ACTIVATION OF PROCARCINOGEN IN EXTRAHEPATIC TISSUES -CONTRIBUTION OF CYP4B1- (1995) (0)
- Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13 (2022) (0)
- OMEPRAZOLE HYDROXYLATION BY CYP2C19 AND CYP3A4: PREDICTION TOWARDS HUMAN LIVER ACTIVITIES USING THE DATA OF RECOMBINANT P450 ENZYMES (1997) (0)
- Title Site-dependent contributions of P-glycoprotein and CYP 3 A to cyclosporinA absorption , and effect of dexamethasone in small intestine of mice (2017) (0)
- A surfactant vehicle, Cremophor EL, increases apparent concentration of cyclosporin A in blood (2005) (0)
- Human C ytochrome P450 Enzymes Involved in the Activation of Environmental Carcinogens (1994) (0)
- O11-02 Cytochrome P450 1B1 genetic polymorphisms in relation to cancer susceptibilities in humans. (2001) (0)
- Concluding remarks (2002) (0)
- P-70(O-7) Development of new umu tester strain expressing human NADPH-P450 reductase and P450 1A2 involved in bioactivation of aromatic amines : (1998) (0)
- Expression of P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of the recombinant enzyme (1997) (0)
- Title Establishment of glycosaminoglycan assays for mucopolysaccharidoses (2017) (0)
- Examining tissue-specific bioactivation in vitro: Cytochrome P450 1B1 and other extrahepatic forms in the metabolism of carcinogens (2000) (0)
- 955 MONOSODIUM GLUTAMATE INJECTION INDUCES A NEW COMPREHENSIVE MODEL OF LIFESTYLE-RELATED NON ALCOHOLIC FATTY LIVER DISEASE WITH NEOPLASTIC NODULES (2008) (0)
- Development of umu-test system Bioactivation of aromatic amines by human P450 1A2, NADPH-P450 reductase and/or O-acetyltransferase-expressing Salmonella typhimurium strains (1999) (0)
- Influence of Cerebellar Hemorrhage on the Higher Cerebral Functions (1986) (0)
- Involvement of human P450s in the metabolic activation of heterocyclic amines using UMU tester strains (2000) (0)
- Variations in contents of liver microsomal cytochrome P450 isofoms and activities of drug oxidations in humans (1999) (0)
- Inhibitory Effects of Tea Catechins on Lipid Peroxidation Induced by Rose Bengal and Blue Light Exposure in Porcine Retinal Homogenate (2007) (0)
- Consideration of post-marketing drug safety assessment in hospitals (2018) (0)
- Metabolic Activation of Procarcinogens by Human Cytochrome P450 Enzymes in Microsomes of Adult and Fetal Livers and of Adult Lungs (1995) (0)
- Risk Factors for Peripheral Neuropathy Induced by Albumin-bound Paclitaxel Plus Gemcitabine Therapy in Pancreatic Cancer Patients (2019) (0)
- Chip-shaped laminated ceramic capacitor (1992) (0)
- Expression of human cytochrome P4501B1 in bacteria (1998) (0)
- Incidence and Risk Factors of Cholinergic Syndromes Induced by FOLFIRINOX in Advanced Pancreatic Adenocarcinoma (2018) (0)
- コンピュータ装置、可搬型デバイス、コンピュータ装置の設定方法、プログラム (2002) (0)
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What Schools Are Affiliated With Tsutomu Shimada?
Tsutomu Shimada is affiliated with the following schools:
