T. W. J. Huizinga

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T. W. J. Huizinga is affiliated with the following schools: Leiden University

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Philosophy

T. W. J. Huizinga's Degrees

PhD Rheumatology University of Amsterdam
Doctorate Medicine University of Amsterdam

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T. W. J. Huizinga's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (2007) (698)
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. (2004) (652)
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs (2010) (595)
Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. (2012) (525)
Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. (2001) (379)
Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles (2005) (339)
Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY) (2012) (283)
Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? (1997) (240)
Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. (2009) (230)
A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study (2010) (217)
Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis (2008) (210)
Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10 (2002) (210)
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. (2001) (198)
MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis (2005) (194)
The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis. (1989) (194)
TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. (2000) (184)
Soluble Fc gamma receptor III in human plasma originates from release by neutrophils. (1990) (182)
The role of autoantibodies in the pathophysiology of rheumatoid arthritis (2017) (177)
Biallelic neutrophil Na-antigen system is associated with a polymorphism on the phospho-inositol-linked Fc gamma receptor III (CD16). (1990) (171)
MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis (2004) (170)
A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis (2007) (167)
Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study (2010) (166)
The Leiden Early Arthritis Clinic. (2003) (164)
Current evidence for a strategic approach to the management of rheumatoid arthritis with disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis (2010) (158)
Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus (2004) (152)
Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair (2003) (152)
Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus (2008) (151)
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles. (2007) (144)
Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst. (1990) (141)
Determination of tumour necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation. (1998) (141)
Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis (2008) (139)
Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. (2001) (138)
Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. (1990) (126)
Long term high intensity exercise and damage of small joints in rheumatoid arthritis (2004) (125)
Binding characteristics of dimeric IgG subclass complexes to human neutrophils. (1989) (124)
Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study (2011) (122)
Genetic influence on cytokine production in meningococcal disease (1997) (119)
Progression of joint damage in early rheumatoid arthritis: association with HLA-DRB1, rheumatoid factor, and anti-citrullinated protein antibodies in relation to different treatment strategies. (2008) (118)
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3 (2003) (118)
A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis (2005) (114)
Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease. (2001) (110)
Illness perceptions in patients with osteoarthritis: change over time and association with disability. (2009) (107)
Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study (2005) (105)
Are differences in interleukin 10 production associated with joint damage? (2000) (104)
Association with joint damage and physical functioning of nine composite indices and the 2011 ACR/EULAR remission criteria in rheumatoid arthritis (2011) (103)
Allele-specific quantification of tumor necrosis factor α (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals (2001) (100)
Childhood-onset Systemic Lupus Erythematosus: clinical presentation and prognosis in 31 patients. (1999) (100)
Undifferentiated arthritis--disease course assessed in several inception cohorts. (2004) (98)
An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid. (2013) (97)
Mortality in neuropsychiatric systemic lupus erythematosus (NPSLE) (2014) (95)
Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis (2010) (95)
Limitations in daily activities are the major determinant of reduced health-related quality of life in patients with hand osteoarthritis (2010) (89)
Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes (1999) (86)
Evidence of central nervous system damage in patients with neuropsychiatric systemic lupus erythematosus, demonstrated by magnetization transfer imaging. (2000) (85)
Association of High Body Mass Index With Decreased Treatment Response to Combination Therapy in Recent‐Onset Rheumatoid Arthritis Patients (2013) (83)
Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens (2010) (80)
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides (2013) (77)
Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy (2004) (76)
The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study (2011) (76)
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis. (2003) (72)
Detection of cerebral involvement in patients with active neuropsychiatric systemic lupus erythematosus by the use of volumetric magnetization transfer imaging. (2000) (72)
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys. (1999) (71)
Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands (2017) (71)
A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus. (2005) (71)
Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis (2009) (71)
Neutrophil Fc-gamma receptors: a two-way bridge in the immune system. (1990) (70)
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice—a translational model for atherosclerosis (2013) (69)
Disease-modifying antirheumatic drug-free sustained remission in rheumatoid arthritis: an increasingly achievable outcome with subsidence of disease symptoms (2015) (69)
Anti-NMDA receptor autoantibodies in patients with systemic lupus erythematosus and their first-degree relatives (2007) (69)
Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus. (2002) (67)
Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis (1999) (66)
Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice. (2012) (64)
Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis. (2008) (63)
Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis. (2010) (62)
Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production (2002) (61)
Concordance between inflammation at physical examination and on MRI in patients with early arthritis. (2015) (61)
Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. (2007) (60)
Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. (2009) (59)
New biomarkers in rheumatoid arthritis. (2012) (58)
Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF−308A in systemic lupus erythematosus (2001) (58)
Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus. (2004) (57)
Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age. (2010) (57)
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications (2020) (56)
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels (2015) (56)
Selective gray matter damage in neuropsychiatric lupus: A magnetization transfer imaging study (2004) (56)
The plasma concentration of soluble Fc‐gamma RIII is related to production of neutrophils (1994) (56)
Undifferentiated arthritis characteristics and outcomes when applying the 2010 and 1987 criteria for rheumatoid arthritis (2011) (56)
High interleukin-10 production in first-degree relatives of patients with generalized but not cutaneous lupus erythematosus. (2000) (56)
Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study (2012) (55)
Association of Pain in Knee Osteoarthritis With Distinct Patterns of Synovitis (2015) (55)
Assistive devices: usage in patients with rheumatoid arthritis (2009) (54)
A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis (2013) (54)
The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis (2008) (53)
Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber. (2001) (53)
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. (2000) (51)
Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis. (2014) (51)
Pretreatment serum levels of anti-cyclic citrullinated peptide antibodies are associated with the response to methotrexate in recent-onset arthritis (2008) (50)
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab (2010) (49)
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population. (2006) (47)
Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients. (2007) (47)
Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus (2002) (47)
Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNFα and IL18 but not CXCL12 (2005) (46)
Induction of neutrophil FC-gamma receptor I expression can be used as a marker for biologic activity of recombinant interferon-gamma in vivo. (1991) (46)
Arthritis of the large joints—in particular, the knee—at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis (2006) (46)
FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians (2006) (46)
Polymorphism within the tumor necrosis factor alpha (TNF) promoter region in patients with ankylosing spondylitis. (1999) (46)
Toward a data-driven evaluation of the 2010 American College of Rheumatology/European League Against Rheumatism criteria for rheumatoid arthritis: is it sensible to look at levels of rheumatoid factor? (2011) (45)
Role of Anti–Carbamylated Protein Antibodies Compared to Anti–Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First‐Degree Relatives, and Healthy Controls (2016) (45)
Variation in IL7R predisposes to sarcoid inflammation (2009) (44)
Interleukin 10-2849AA genotype protects against pre-eclampsia (2004) (43)
Metabolic profiling reveals differences in concentrations of oxylipins and fatty acids secreted by the infrapatellar fat pad of donors with end-stage osteoarthritis and normal donors. (2013) (43)
Protection against rheumatoid arthritis by HLA: nature and nurture (2008) (43)
EULAR points to consider for conducting clinical trials in systemic lupus erythematosus (2008) (43)
Determinants of absence of osteoarthritis in old age (2011) (43)
Female sex hormones at the onset of systemic lupus erythematosus affect survival. (1998) (42)
Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans. (2017) (41)
RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro. (2007) (41)
MRI-detected subclinical joint inflammation is associated with radiographic progression (2014) (39)
Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis. (2002) (38)
Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. (2011) (38)
Biomarkers for radiographic progression in rheumatoid arthritis. (2014) (37)
Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis (2016) (36)
EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: literature based evidence for the selection of endpoints (2008) (36)
The influence of synovial fluid on adenovirus-mediated gene transfer to the synovial tissue. (2001) (36)
Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis (2010) (36)
Prevalence of vertebral fractures in a disease activity steered cohort of patients with early active rheumatoid arthritis (2012) (35)
Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study. (2008) (35)
Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation. (2007) (34)
Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population (2009) (34)
Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis (2013) (34)
The BeSt way of withdrawing biologic agents. (2013) (33)
Lupus and the central nervous system (2008) (33)
CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis (2014) (33)
No increased risk of valvular heart disease in adult poststreptococcal reactive arthritis. (2009) (33)
Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients (2013) (32)
Clinical value of soluble IgG Fc receptor type III in plasma from patients with chronic idiopathic neutropenia. (1998) (30)
Mortality in osteoarthritis patients (2015) (30)
Complement levels and anti-C1q autoantibodies in patients with neuropsychiatric systemic lupus erythematosus (2016) (29)
The accuracy of diagnosing neuropsychiatric systemic lupus erythematosus in a series of 49 hospitalized patients. (1999) (29)
HLA class II is associated with distal interphalangeal osteoarthritis (2003) (29)
‘Insights in the relationship of joint space narrowing versus erosive joint damage and physical functioning of patients with RA’ (2012) (28)
Drug therapy in undifferentiated arthritis: a systematic literature review (2013) (28)
Evaluating joint destruction in rheumatoid arthritis: is it necessary to radiograph both hands and feet? (2012) (27)
Active MMPs captured by alpha 2 macroglobulin as a marker of disease activity in rheumatoid arthritis. (2003) (26)
A neuroimaging follow up study of a patient with juvenile central nervous system systemic lupus erythematosus (2003) (26)
A decrease in disease activity score (DAS) level is associated with a decrease in health assessment questionnaire (HAQ) score, independent of follow-up duration, during 5 years of tightly controlled treatment: results from the BeSt study (2010) (26)
No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes. (2004) (26)
Concentration-controlled treatment of lupus nephritis with mycophenolate mofetil (2013) (26)
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. (2013) (24)
Doyle Index is a valuable additional pain measure in osteoarthritis. (2010) (23)
Risk factors for reported influenza and influenza-like symptoms in patients with rheumatoid arthritis (2012) (22)
Hyperpigmentation of the skin due to hydroxychloroquine (2008) (22)
Autoantibodies within families of patients with systemic lupus erythematosus are not directed against the same nuclear antigens. (2001) (21)
The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice (2011) (21)
Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts. (2013) (21)
Risk of alanine transferase (ALT) elevation in patients with rheumatoid arthritis treated with methotrexate in a DAS-steered strategy (2013) (20)
Association of Valine and Leucine at HLA–DRB1 Position 11 With Radiographic Progression in Rheumatoid Arthritis, Independent of the Shared Epitope Alleles but Not Independent of Anti–Citrullinated Protein Antibodies (2015) (18)
IL2RA is associated with persistence of rheumatoid arthritis (2015) (18)
Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis (2013) (18)
The effect of pentoxifylline on human neutrophil migration: a possible role for cyclic nucleotides. (1997) (18)
Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (2003) (17)
OP0173 Concordance Between Joint Swelling or Tenderness at Physical Examination and Inflammation on MRI in Early Arthritis Patients (2013) (17)
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with α2 macroglobulin in serum of rheumatoid arthritis patients (2007) (17)
Sensitivity to change of the MOS SF-36 quality of life assessment questionnaire in patients with systemic lupus erythematosus taking immunosuppressive therapy. (2000) (16)
Soluble CD95 concentrations are increased in patients with severe systemic lupus erythematosus, but not in their first degree relatives (2001) (16)
Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis (2011) (16)
FRI0090 Analysis of neutrophils, lymphocytes, and platelets in pooled phase 2 and phase 3 studies of baricitinib for rheumatoid arthritis (2017) (16)
Tumour necrosis factor alpha gene polymorphisms and rheumatic diseases. (1998) (16)
Validity of joint space width measurements in hand osteoarthritis. (2011) (16)
THU0114 Effect of Anti-Cyclic Citrullinated Peptide 2 Immunoglobulin M Serostatus on Efficacy Outcomes Following Treatment with Abatacept Plus Methotrexate in the Avert Trial (2015) (15)
Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients (2017) (14)
Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies (2019) (14)
OP0095 Randomized, Placebo-Controlled Trial To Evaluate Clinical Efficacy and Structure Modifying Properties of Subcutaneous Etanercept (ETN) in Patients with Erosive Inflammatory Hand Osteoarthritis (OA) (2016) (13)
Association between polymorphisms in the human chemokine receptor genes CCR2 and CX3CR1 and rheumatoid arthritis. (2003) (13)
Effectiveness of four dynamic treatment strategies in patients with anticitrullinated protein antibody-negative rheumatoid arthritis: a randomised trial (2016) (13)
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis: a combined analysis of multiple studies (2021) (13)
Correlation between expression of CD44 splice variant v8-v9 and invasiveness of fibroblast-like synoviocytes in an in vitro system. (2004) (13)
Susac syndrome: a report of four cases and a review of the literature. (2015) (12)
The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of HLA-DRB1*0401. (2006) (12)
Simplified versions of the original disease activity score: validation in the BeSt trial (2011) (12)
CNS involvement in systemic lupus erythematosus: a case with remarkable histopathological findings (2001) (12)
Is site of back pain related to location of MRI lesion in patients with chronic back pain included in the SPACE-cohort? (2016) (12)
Drug-free holiday in patients with rheumatoid arthritis: a qualitative study to explore patients’ opinion (2014) (12)
Macrophage migration inhibitory factor (MIF) -173 polymorphism is associated with clinical erythema nodosum in Löfgren's syndrome. (2014) (11)
Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression (2012) (11)
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCP) affects severity of rheumatoid arthritis (2004) (11)
A comparison between the simplified erosion and narrowing score and the Sharp–van der Heijde score: post hoc analysis from the BeSt study (2010) (11)
THU0093 Clinical, radiographic, and immunogenic effects after 1 year of tocilizumab (TCZ)-based treatment strategy with and without methotrexate (MTX) in RA: The act-ray study (2013) (11)
Targeted therapies in rheumatoid arthritis: Focus on rituximab (2007) (11)
Genetic variants in IL-15 associate with progression of joint destruction in rheumatoid arthritis, a multi cohort study (2012) (10)
The METEOR initiative: the way forward for optimal, worldwide data integration to improve care for RA patients. (2014) (10)
CNS involvement in primary Sjögren’s syndrome: a case with a clue for the pathogenesis (2000) (10)
Rheumatologists’ adherence to a disease activity score steered treatment protocol in early arthritis patients is less if the target is remission (2016) (10)
The major risk alleles of age‐related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA) (2011) (10)
Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients. (2006) (10)
First in patient study of anti-GM-CSF monoclonal antibody (MOR103) in active rheumatoid arthritis: Results of a phase 1b/2a randomized, double-blind, placebo-controlled trial (2012) (10)
Administration of an adeno-associated viral vector expressing interferon-β in patients with inflammatory hand arthritis, results of a phase I/II study. (2021) (9)
SAT0210 First-in-Patient Study of Namilumab, an Anti-GM-CSF Monoclonal Antibody, in Active Rheumatoid Arthritis: Results of the Priora Phase IB Study (2015) (9)
The effect of promoter strength in adenoviral vectors in hyperplastic synovium. (2000) (9)
Regulation of tumor necrosis factor-alpha production: basic aspects and pharmacological modulation. (1996) (9)
Aesthetic dissatisfaction in patients with hand osteoarthritis and its impact on daily life (2016) (9)
Does the season at symptom onset influence the long-term severity of radiographic joint destruction in rheumatoid arthritis? (2012) (8)
Interleukin-10 promoter polymorphisms in male and female fertility and fecundity (2006) (8)
OP0154 Clinical and radiological outcomes of four disease activity driven treatment strategies: 8-year results of the best study (2013) (8)
Autoantibodies predict progression to rheumatoid arthritis in undifferentiated arthritis: a prospective cohort study (2003) (8)
A7.10 Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts (2012) (8)
Is current smoking status and its relationship to anti-cyclic citrullinated peptide antibodies a predictor of worse response to biological therapies in rheumatoid arthritis patients? (2018) (8)
Health care in systemic lupus erythematosus (SLE): the patient’s perspective (2014) (8)
Translating basic research into clinical rheumatology. (2008) (8)
The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis (2010) (8)
RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians. (2005) (7)
OP0025 Different Patterns of Synovitis Present in OA Patients Associate Differentially with Pain (2013) (7)
SAT0041 The Course of Bone Marrow Edema in Early Undifferentiated and Rheumatoid Arthritis; A Longitudinal MRI Study on Bone Level (2015) (7)
SAT0585 GEO-EPIDEMIOLOGY OF AUTOANTIBODIES IN RA: DIFFERENT PREVALENCES IN FOUR ETHNICALLY DIVERSE RA POPULATIONS (2020) (6)
SAT0279 Patients fulfilling the imaging-arm and patients fulfilling the HLA-B27-arm of the asas axial spondyloarthritis classification criteria: Are they similar? (2013) (6)
The invasiveness of fibroblast-like synoviocytes is of relevance for the rate of joint destruction in patients with rheumatoid arthritis and is a patient characteristic (2005) (6)
343 THE EFFECTS OF SHOCKWAVE ON BONE HEALING AND SYSTEMIC CONCENTRATIONS OF NITRIC OXIDE ( NO ) , TGF-β 1 , VEGF AND BMP-2 IN LONG BONE NON-UNIONS (2009) (6)
Does a Genetic Variant in FOXO3A Predict a Milder Course of Rheumatoid Arthritis? (2014) (6)
Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care (2019) (6)
Osteoarthritis development is induced by increased dietary cholesterol in APOE*3Leiden.CETP mice, a translational model for atherosclerosis, and can be inhibited by atorvastatin (2013) (6)
No therapeutic effect of plasmin antagonist tranexamic acid in rheumatoid arthritis. A double-blind placebo-controlled pilot study. (2003) (6)
Adenoviral-mediated gene transfer to the synovial tissue. (2002) (5)
Health care usage in Dutch systemic lupus erythematosus patients (2011) (5)
Fc-gamma receptors: mediators, targets and markers of disease. (1991) (5)
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence for the existence of distinctive pathways relevant to disease (2004) (4)
Mortality in osteoarthritis: a systematic review (2013) (4)
A2.05 Carbamylated autoantigens facilitate the break of tolerance: A novel mechanism in the pathogenesis of autoimmune arthritis (2016) (4)
Randomised, placebo-controlled trial to evaluate clinical efficacy and structure modifying properties of subcutaneous etanercept in patients with erosive inflammatory hand osteoarthritis (2017) (4)
Different patterns of synovitis as seen on CE-MRI in patients with knee osteoarthritis (2013) (4)
Adrenic acid as a novel anti-inflammatory player in osteoarthritis (2018) (4)
FRI0152 On Drug and Drug-Free Remission by Baseline Disease Duration in the Avert Trial: Abatacept Versus Methotrexate Comparison in Patients with Early Rheumatoid Arthritis (2015) (3)
Stringent Criteria for Low Disease Activity and Remission after 12 Months of Treatment, and after Treatment Withdrawal, with Abatacept Monotherapy, Abatacept with Methotrexate or Methotrexate Alone in Early Rheumatoid Arthritis. (2014) (3)
Prediction and prevention of rheumatoid arthritis (2007) (3)
FRI0132 A multi-biomarker disease activity score (the vectra DA algorithm score) reflects clinical remission for rheumatoid arthritis (RA) in the best study (2013) (3)
OP0098 Effect of Etanercept on Synovitis and Bone Marrow Lesions in Erosive Hand Osteoarthritis (2016) (3)
Use of methotrexate in undifferentiated arthritis. (2010) (3)
THU0431 Localisation of bone marrow edema in sacroiliac joints in spondyloarthritis patients: Does the site of lesions change over a 3-month period? (2013) (3)
OP0271 Prevalence of Structural Lesions on MRI of the Sacroiliac Joints in Patients with Early Axial Spondyloarthritis and Patients with Back Pain (2013) (3)
OP0272 Prevalence of Structural Lesions MRI-Spine in Patients with (Possible) Axial Spondyloarthritis (AXSPA) Included in the Space-Cohort (2013) (2)
MMP-1, MMP-3 and MMP-10 are involved in the degradation of cartilage (2001) (2)
Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis (2018) (2)
ACPA production by circulating B cells isolated from peripheral blood of patients with rheumatoid arthritis (2012) (2)
Diagnostic value of performing chest x-rays in patients presenting with recent-onset arthritis (2011) (2)
SAT0258 Synergetic b-cell immunomodulation with rituximab and belimumab is clinically effective in severe and refractory systemic lupus erythematosus – the synbiose proof-of-concept study (2017) (2)
Health care usage in Dutch systemic lupus erythematosus patients (2013) (2)
SAT0242 Inflammation in the Posterior Elements of the Spine is Infrequent in Patients with Recent Onset Axial Spondyloarthritis, Especially If No Inflammation in the Vertebral Bodies is Observed (2013) (2)
Degree of synovitis on MRI is correlated with histological and macroscopic features of synovial tissue inflammation in knee osteoarthritis (2012) (2)
in Dutch Caucasians arthritis associated with susceptibility to rheumatoid FCRL3 promoter 169 CC homozygosity is (2007) (2)
AB0446 Treatment Effects and Minimal Clinically Important Differences in Patient-Reported Outcomes Following Treatment and Withdrawal of Abatacept, Methotrexate Or Combination Therapy in Patients with Early Rheumatoid Arthritis (2015) (2)
AB1293 Is it useful to repeat an MRI in the diagnostic work-up for spondyloarthritis? (2013) (2)
FRI0061 Remission after one year follow up of the improved-study, a randomized clinical trial aiming at remission in patients with early rheumatoid and undifferentiated arthritis (2013) (2)
A descriptive study of synovial fluid changes in cytokine, chemokine and growth factor levels between osteoarthritis patients and healthy donors (2012) (2)
THU0444 Assessment of Global Disease Activity in RA by Patients and Physicians: Cultural Differences across Countries in the Meteor Database (2014) (2)
Effect of Etanercept on Several Soluble Biomarkers in a Randomized Controlled Trial of Patients with Erosive Hand Osteoarthritis (2016) (2)
Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles (2007) (2)
To What Extend Do Auto-Antibodies Help to Identify High-Risk Patients in Systemic Sclerosis? (2017) (2)
THU0167 ASSOCIATIONS BETWEEN RHEUMATOID ARTHRITIS DISEASE ACTIVITY AND PATIENT-REPORTED OUTCOMES IN SARILUMAB CLINICAL TRIALS (2020) (2)
THU0464 A genome-wide association study of gout in people of european ancestry (2017) (2)
Effect of etanercept on synovitis and bone marrow lesions in erosive hand osteoarthritis (2017) (2)
OP0049 Presence of ACPA in a Large (>40.000) Population Based Cohort from the Netherlands (2015) (2)
PS7:129 Synergetic b-cell immunomodulation with rituximab and belimumab combination treatment in severe, refractory sle (2018) (2)
Mortality in osteoarthritis patients consulting health care (2012) (2)
SAT0350 Glucose and Insulin Concentrations in Association with Hand Osteoarthritis: The Neo Study (2013) (2)
A4.5 Do High Molecular Weight Adiponectin Levels Associate with Radiographic Progression in early Rheumatoid Arthritis and Hand Osteoarthritis? (2013) (2)
Towards a data-driven evaluation of the 2010 ACR/EULAR criteria for rheumatoid arthritis : Is it sensible to look at levels of rheumatoid factor? (2010) (2)
Age affects joint space narrowing in patients with early active rheumatoid arthritis (2016) (1)
PTPN22 as a rheumatoid arthritis susceptibility but not severity gene (2005) (1)
THU0259 10 Years of Treat-To-Target Therapy in Rheumatoid Arthritis Patients (The Best Study): Clinical and Radiographic Outcomes (2014) (1)
POS0097 JOINT INFLAMMATION TENDS TO RECUR IN THE SAME JOINTS DURING THE RHEUMATOID ARTHRITIS DISEASE COURSE (2021) (1)
THU0013 Interaction between two common HLA antigens defines a subset of individuals at a very high risk for ankylosing spondylitis (2013) (1)
Classifying lupus nephritis: a 32-year-old woman with systemic lupus erythematosus and nephritic syndrome. (2001) (1)
FRI0096 Haq baseline values in an international registry of ra patients during the era of biologic terapies: the 2013 meteor database. (2013) (1)
THU0704 Evaluation of the accuracy of hand and foot mri in the early identification of ra: using the prevalence of low-graded inflammation in the symptom-free population as reference reduces false-positive mri results (2017) (1)
OP0179 Smoking as a Risk Factor for the Severity of Rheumatoid Arthritis (2013) (1)
Effects of TIMP-1 and TIMP-3 gene transfer on invasiveness, proliferation and apoptosis of rheumatoid arthritis (RA) synovial fibroblasts (RA-SF) (2002) (1)
THU0052 Fibroblast-like synoviocytes from rheumatoid arthritis patients are more invasive than from osteoarthritis in an in vitro system: correlation with growth characteristics and expression of mmp-1, mmp-3 and mmp-10 (2001) (1)
SAT0236 Prevalence of Syndesmophytes in Patients with Chronic Back Pain Suspected of Axial Spondyloarthritis (AXSPA) Not Fulfilling the Modified New York (MNY) Criteria (2013) (1)
FRI0242 Association between clinical and radiographic responses, and physical function in a phase 3 study of sarilumab plus methotrexate in patients with active, moderate-to-severe rheumatoid arthritis (2017) (1)
SAT0228 Performance of MRI Compared to Conventional Radiographs in the Detection of Structural Lesions in the Sacroiliac Joints in Patients With Recent Onset Axial Spondyloarthritis (2013) (1)
Adiponectin is a predictor for radiographic progression in early RA patients, independently of anti-CCP antibodies (2011) (1)
SAT0030 Quality Indicators (QIS) in Rheumatoid Arthritis (RA) in Clinical Practice: Results from Measurement of Efficacy of Treatment in The ERA of Outcome in Rheumatology (Meteor) Database (2013) (1)
OP0252 Rheumatoid arthritis patients with continued low disease activity have similar outcomes over 10 years, regardless of initial therapy (2017) (1)
Presence of anti-RNP-A and anti-RNP-C antibodies is inversely associated with renal symptoms of systemic lupus erythematosus (2003) (1)
SAT0199 An estimate of the proportion of patients with sle receiving off-label treatment with rituximab in european countries (2013) (1)
THU0063 A Substantial Decrease in Work Productivity and Physical Health-Related Quality of Life in Patients with Chronic Back Pain in the Space-Cohort (2014) (1)
Changes in hand bone mineral density and the association with the level of disease activity in patients with RA (2011) (1)
THU0257 Acpa-Negative RA Patients Benefit from Initial Combination Therapy with Early Clinical Improvement - A Sub-Analysis of the Best Study (2014) (1)
SAT0275 Almost 40% of patients with chronic back pain starting before the age of 45 fulfill the asas axial spondyloarthritis criteria (2013) (1)
SAT0225 Do Bone Marrow Edema (BME) Lesions in the Sacroiliac Joint (SIJ) Change into Fatty Lesions Over A 3-Month Period in Patients with Axial Spondyloarthritis (AXSPA)? (2013) (1)
Fcγ Receptors of Myeloid Cells (1993) (1)
A1.8 Magnetic Resonance Imaging of Hand and Foot Joints of Patients with ACPA Positive Arthralgia without Clinical Arthritis (2013) (1)
FRI0097 Repair of joint damage in newly diagnosed rheumatoid arthritis patients occurs but does not relate to previous suppression of inflammation; an 8-years sub analysis in the best-cohort (2017) (1)
Functional regulatory immune responses against human cartilage glycoprotein-39 in health versus proinflammatory responses in rheumatoid arthritis (2005) (1)
Retraction for Schuerwegh et al., Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis (2013) (1)
NT-proBNP and sRAGE levels in early rheumatoid arthritis (2022) (1)
THU0635 Precise and simple algorithm to identify ra cases in electronic medical records (2017) (1)
Transfer of protease inhibitors to inhibit cartilage destruction (2001) (1)
THU0091 High multi-biomarker disease activity score is associated with high risk of radiographic progression in six studies (2017) (1)
FRI0675 Rabiopred, an innovative theranostic tool to assist clinicians select an optimal anti-tnf alpha biological therapy for rheumatoid arthritis patients (2018) (1)
SAT0243 Influence of Taking Structural Lesions into Account in Addition to Inflammatory Lesions on MRI of the Sacroiliac Joints On The Classification of Patients with Possible Axial Spondyloarthritis (2013) (1)
A8.09 Trained immunity in monocytes from rheumatoid arthritis patients and healthy individuals (2016) (1)
Gene Therapy of Arthritis and Related Disorders--First International Meeting. 2-3 December 1998, Bethesda, USA. (1999) (1)
FRI0155 Long-term cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis – 5 year follow-up data from the best study (2013) (1)
A2.15 Ra phenotype at presentation differs among patients with few versus many autoantibodies (2016) (1)
AB1282 Assessing active inflammation in sacroiliac joints (SIJ) in spondyloarthritis patients: No added value of gadolinium compared to short TAU inversion recovery (STIR) sequence (2013) (1)
Proposal for An Adaptation of the Berlin Algorithm for Diagnosing Spa : Results of the SPondyloArthritis Caught Early (SPACE)-Cohort (2011) (1)
Synovial CD4+ T cells associate with pain in osteoarthritis: is there a role for fatty acids? (2016) (1)
THU0095 IMPACT OF BASELINE EROSION SCORE ON RESPONSE TO TREATMENT AND FUTURE RADIOLOGICAL DAMAGE IN AVERT-2, A RANDOMISED PHASE IIIB STUDY OF ABATACEPT IN MTX-NAÏVE, ANTI-CITRULLINATED PROTEIN ANTIBODY–POSITIVE (ACPA+) PATIENTS WITH EARLY RA (2020) (1)
SAT0241 Volatility of the Site and Type of Lesions in the Spine in Patients with Recent Onset Spondyloarthritis and Possible Spondyloarthritis Over A 3-Month Period (2013) (1)
A1.1 Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients (2013) (1)
A1.45 Hyperglycosylation of ACPA-IGG variable domains modulates reactivity to citrullinated antigens (2014) (1)
SAT0278 How useful is imaging of the SI-joints (MRI and/or X-ray) in patients with possible spondyloarthritis in the diagnostic work-up? (2013) (1)
Low avidity anti-citrullinated protein antibodies (ACPA) are associated with high radiographic progression in rheumatoid arthritis (2011) (1)
A1.25 Visualisation and characterisation of citrullinated antigen-specific B cells from peripheral blood of patients with rheumatoid arthritis (2015) (1)
IS IT USEFUL TO REPEAT MRI IN THE DIAGNOSTIC WORK-UP FOR SPONDYLOARTHRITIS? (2012) (1)
SAT0342 Mortality in Osteoarthritis : A Systematic Review (2013) (1)
FRI0225 Persistent Work Productivity Loss Over One Year in Patients with Axial Spondyloarthritis and Other Forms of Chronic Back Pain from the Space-Cohort (2015) (1)
THU0001 Variation in granzyme-b is associated with progression of joint destruction in rheumatoid arthritis (2013) (1)
FRI0109 Disease Activity is Strongly Associated with Work Productivity and Physical Health-Related Quality of Life in Patients with Early Axial Spondyloarthritis in the Space-Cohort (2014) (1)
SAT0084 Evaluation of Functional Disability in Patients with Clinically Suspect Arthralgia (2016) (1)
FRI0451 Continuous presence of igm anti-topoisomerase i antibodies indicates an ongoing immune response in systemic sclerosis (2018) (1)
FRI0120 Prevalence and predictors of vertebral fractures after 5 years of disease activity steered treatment in patients with early active rheumatoid arthritis (2013) (1)
Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis (2012) (0)
Specialized pro-resolving lipid mediators in osteoarthritis patients: Evidence for an anti-inflammatory role (2015) (0)
' s response to reviews Title : Prevalence of vertebral fractures in a disease activity steered cohort of patients with early active rheumatoid arthritis (2012) (0)
mRi detected subclinical joint infl ammation is associated with radiographic progression detected subclinical joint detected subclinical joint associated with is associated with (2014) (0)
471 HIGH BODY MASS INDEX OF OSTEOARTHRITIS PATIENTS ASSOCIATES WITH SYNOVIUM INDUCED CHANGES IN CARTILAGE METABOLISM (2010) (0)
Human cartilage glycoprotein 39-directed T cell responses in health and arthritic diseases (2004) (0)
Aiming for a shorter scanning protocol in early arthritis mRi: can gadolinium contrast administration be eliminated? (2014) (0)
FRI0098 ASSOCIATION BETWEEN THE SEROLOGIC STATUS OF ISOTYPE-SPECIFIC AUTOANTIBODIES AND THERAPEUTIC EFFICACY IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: A PROSPECTIVE ULTRASOUND COHORT STUDY IN JAPAN (2020) (0)
MPP protein and activity levels in synovial fluid from patients with joint injury , inflammatory arthritis , and (2005) (0)
THU0120 Do High Molecular Weight Adiponectin Levels Associate with Radiographic Progression in Rheumatoid Arthritis and Hand Osteoarthritis? (2013) (0)
OP0090 Mri Lesions Originating from either Axspa or Degeneration Are Related To Site of Pain in Patients with Chronic Back Pain Included in The Space-Cohort (2016) (0)
SAT0087 Does the season of symptom onset influence the severity of radiographic joint destruction in rheumatoid arthritis? (2013) (0)
The Presence of a Large Number of Autoantibodies at Baseline Is Favourable for Early Treatment Response but Unfavourable for Drug-Free Remission in RA Patients (2017) (0)
The association of serum glucose and insulin concentrations with hand osteoarthritis: the NEO study (2013) (0)
SAT0589 Replacing Radiographic Sacroiliitis by Structural Lesions on MRI of the Sacroiliac Joints: Impact on the Classification of Patients According to the Asas Axial SPA Criteria (2015) (0)
A2.10 The isotype and subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients (2016) (0)
OP0272 PREDNISONE USE AND THE INCIDENCE OF HYPERGLYCEMIA OR DIABETES IN PATIENTS WITH RHEUMATOID ARTHRITIS; A 10-YEAR SUB ANALYSIS OF THE BeSt STUDY. (2022) (0)
FRI0094 Outcomes of two years of remission steered treatment in early arthritis patients (2013) (0)
AB0251 Are acpa associated with more bone loss over time in patients with ra? (2018) (0)
THU0469 Genetic Variants in IL-6, IL-10, C5-TRAF1 and FCRL3 and Progression of Joint Damage in Rheumatoid Arthritis; A Study on Six Cohorts (2014) (0)
Prediction of severity of joint Destruction in Rheumatoid Arthritis (2014) (0)
SAT0235 Prevalence of Inflammatory Lesions MRI-SPINE in Patients with Chronic Back Pain of <2 Years Duration Included in the Space-Cohort (2013) (0)
OP0021 Genetic Factors for the Severity of ACPA-Negative Rheumatoid Arthritis in Two Cohorts of Early Disease: A Genome-Wide Study (2013) (0)
FRI0349 Exploring Symptom Duration, Auto Antibodies and Inflammation in Order to Explain the Predictive Value of Baseline Erosions for Future Structural Damage in Rheumatoid Arthritis (2014) (0)
OP0028 Effects of Sarilumab plus MTX on Clinical, Radiographic, and Functional Endpoints in Patients with Moderate-To-Severe Rheumatoid Arthritis: Results of A Phase 3, Randomized, Double-Blind, Placebo-Controlled, International Study (2014) (0)
TherapeuticsClinical Studies Including Force of the EULAR Standing Committee for systemic lupus erythematosus. Report of a Task EULAR recommendations for the management of (2008) (0)
AB1309 Differential diagnostic value of 1.5 TESLA extremity MRI in early arthritis (2013) (0)
SAT0359 The course of mouth opening and its relationship with disease characteristics, global functioning, health-related quality of life and mouth handicap in patients with systemic sclerosis (2017) (0)
C1q deficient individuals have a wide variety of clinical presentation, quality of life and life expectancy (2014) (0)
4312Left ventricular systolic function in patients with systemic lupus erythematosus and its association with cardiovascular events (2019) (0)
AB0430 MORTALITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND NEUROPSYCHIATRIC SYMPTOMS (2020) (0)
PReS-FINAL-2109: Genetic variations in patients with juvenile idiopathic arthritis and uveitis (2013) (0)
OP0041 Does treatment strategy influence the ability to achieve and sustain dmard-free remission in ra?; results of a longitudinal study comparing an intensive das-steered treatment strategy with treat-to-target in routine care (2018) (0)
THU0026 A single nucleotide polymorphism on the il-10 locus defines an expression polymorphism and a possible risk factor to develop ra (2001) (0)
Early treatment of recent-onset rheumatoid arthritis patients impairs the effect of HLA class II antigents on the progression of joint destruction (2001) (0)
FRI0013 Anti-Carbamylated Protein Antibodies (ANTI-CARP) Precede the Onset of Rheumatoid Arthritis (2014) (0)
THU0040 In Rheumatoid Arthritis, Smoking is not Associated with Anti-Citrullinated Protein Antibodies (ACPA) Per SE, but with the Concurrent Presence of Rheumatoid Factor, Acpa and Anti-Carbamylated Protein Antibodies (2015) (0)
Repair of Joint Damage Is Rare in Newly Diagnosed Rheumatoid Arthritis Patients and Appears Not to Relate to Previous Suppression of Inflammation (2017) (0)
Invasion of synoviocytes is inhibited by gene transfer of TNF-BP or IL10 in an in vitro invasion model (2001) (0)
FRI0356 Antisense long noncoding rnas are deregulated in skin tissue of ssc patients (2017) (0)
AB0782 Health-Related Quality of Life is Substantially Affected at Baseline and After One Year in Patients with Axial Spondyloarthritis and Other Forms of Chronic Back Pain Participating in the Space-Cohort (2015) (0)
Chapter 7 Changes in synovial inflammation over time in rheumatoid arthritis (2008) (0)
P026 Baseline autoantibody profile in rheumatoid arthritis associates with early treatment response but not long-term outcomes (2018) (0)
111 ANTI-INFLAMMATORY EFFECT OF ROSUVASTATIN AND ROSIGLITAZONE SUPPRESSES DEVELOPMENT OF DIET-INDUCED OSTEOARTHRITIS IN HUMAN CRP TRANSGENIC MICE (2011) (0)
SAT0297 DIFFERENTIAL PHENOTYPES OF DISEASE-SPECIFIC AUTO-REACTIVE B CELL RESPONSES IN PATIENTS WITH SYSTEMIC SCLEROSIS (2020) (0)
Fibroblast-like synoviocytes from rheumatoid arthritis patients express less flice-inhibitory protein than FLS from osteoarthritis, trauma and prosthesis loosening patie (2002) (0)
Biomarkers in sarcoidosis 4515 The role of vitamin D 3 in the local inflammatory process in sarcoidosis ( SA ) (2011) (0)
OP0114 Improving early recognition of arthritis: Evaluation of the first year results on two early arthritis recognition clinics (2013) (0)
Fibroblast-like synoviocytes obtained from different joints at different times from one patient show similar invasiveness in vitro (2003) (0)
AB1002 Aesthetic dissatisfaction in hand osteoarthritis patients, its impact and risk factors (2013) (0)
AB1243 TRAINING AND VALIDATION OF A MULTIVARIATE PREDICTOR OF RISK OF RADIOGRAPHIC PROGRESSION FOR PATIENTS WITH RHEUMATOID ARTHRITIS (2020) (0)
A Temporal switch towards a more resolvingchronic toll-like receptor signalling induces lipid profile in monocyte-derived macrophages receptor signalling induces a temporal switch towards a more resolving lipid profile in monocyte-derived macrophages (2017) (0)
FRI0055 Erosions in the Foot at Baseline are Predictive of Orthopedic Shoes Use After 10 Years of Treat to Target Therapy – Results from the Best Study (2015) (0)
THU0069 In ra, becoming seronegative over the 1st year of dmard treatment does not translate to better chances of sustained drug-free remission in the long-term (2018) (0)
A single nucleotide polymorphism on the IL-10 locus defines an expression polymorphism and a possible risk factor to develop RA (2001) (0)
CD25+ regulatory T cells can be used therapeutically in collagen-induced arthritis (2004) (0)
OP0169 A combination of proteins as measured within the multi-biomarker disease activity score at presentation of ra identifies a group of acpa-negative ra patients with high likelihood of developing dmard-free sustained remission (2018) (0)
AB1114 HANDWORK VS MACHINE; A COMPARISON OF RHEUMATOID ARTHRITIS PATIENT POPULATIONS AS IDENTIFIED BY MACHINE-LEARNING AND CRITERIA-BASED CHART REVIEW. (2020) (0)
The Efficacy Of Etanercept In Combination With Methotrexate In Moderate To Severe Rheumatoid Arthritis Is Not Dependent On The Dosage Of Methotrexate (2013) (0)
AB0667 A PROSPECTIVE STUDY INTO COVID-19 LIKE SYMPTOMS IN PATIENTS WITH AND WITHOUT IMMUNE MEDIATED INFLAMMATORY DISEASES OR IMMUNOMODULATING DRUGS (0)
Clinical trials aiming to prevent RA cannot detect prevention without adequate risk stratification: a trial of MTX versus placebo in UA as an example (2018) (0)
Toll-like receptor triggering can synergise with ige-mediated activation in ACPA+RA (2012) (0)
FRI0181 The Course of Fatigue in Rheumatoid Arthritis; A 10 Year Longitudinal Cohort Study (2014) (0)
FRI0083 Large joint damage after 8 years of das-steered treatment in early rheumatoid arthritis (RA) patients (2013) (0)
FRI0173 Efficacy of Sarilumab in Moderate and Severe Rheumatoid Arthritis as Defined by Baseline DAS28-CRP Scores: The Mobility Study (2015) (0)
Using genetics to differentiate patients with similar symptoms: application to inflammatory arthritis in the rheumatology outpatient clinic (2019) (0)
OP0209 Genetic variance in IL2RA associates with progression of joint destruction and circulating SIL-2RA levels in rheumatoid arthritis (2013) (0)
FRI0083 Elevated il-16 level is a non-genetic characteristic of patients with severe systemic lupus erythematosus (2001) (0)
Human anti-citrullinated protein antibodies (ACPA) not only activate the classical- but also the alternative complement pathway (2009) (0)
FRI0585 HIGH-THROUGHPUT METHODOLOGY FOR EMR-BASED IDENTIFICATION OF CLINICAL SUB-PHENOTYPES IN COMPLEX PATIENT POPULATIONS (2020) (0)
Presence of SARS-CoV-2 antibodies in patients with COVID-19 like symptoms from the IENIMINI cohort (2022) (0)
7 Exploring high fat diet-induced osteoarthritis in APOE * 3 Leiden . CETP mice (2013) (0)
AB0012 In the elderly acpa-negative ra is more prevalent than acpa-positive ra while the composition of the acpa-response appears identical (2017) (0)
Anti-citrullinated protein antibodies have a low avidity compared to antibodies against recall-antigens (2010) (0)
FRI0076 Low Disease Activity or DAS-Remission as Treatment Target in Early Rheumatoid Arthritis Patients (2016) (0)
FRI0044 Early treatment with dmards improves radiological outcome in patients with rheumatoid arthritis (2001) (0)
False positivity of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus (2004) (0)
Identification of genes associated with the presence of ectopic lymphoid structures in rheumatoid arthritis synovial tissues (2005) (0)
EXTENDED REPORT Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis (2003) (0)
New Genetic Risk Loci for the Radiographic Severity of Rheumatoid Arthritis (2012) (0)
FRI0122 Evaluation of the Two-Step Referral Strategy for Axial Spondyloarthritis in the Spondyloarthritis Caught Early Cohort (2014) (0)
Elevated IL-16 level is a non-genetic characteristic of patients with severe systemic lupus erythematosus (2001) (0)
OP0089 Association between tnf -308a and systemic lupus erythematosus in relation to hla-dr3 and six microsatellite markers on the short arm of chromosome vi (2001) (0)
Association of the CCR5Δ32 variant with juvenile idiopathic arthritis in a meta-analysis (2011) (0)
Genomic / genetic / proteomic : the added value to arthritis research and treatment 1 Osteoarthritis : degeneration of matrix or cells ? (2015) (0)
OP0190 Smoking is Not Primarily Associated with ACPA, but with the Presence of Multiple Autoantibodies in RA (2013) (0)
P5410Clinical and echocardiographic associates of all-cause mortality and cardiovascular outcomes in patients with systemic sclerosis (2017) (0)
Genetic analysis of ethnicity of sarcoidosis patients in the Netherlands (2013) (0)
A7.1 A Genetic Variant in the Region of MMP-9 is Associated with Serum Levels and Progression of Joint Damage in Rheumatoid Arthritis (2013) (0)
Polymorphisms in CCR5 confer susceptibility to Löfgren's syndrome and may regulate the immune response (2011) (0)
OP0219 MORTALITY OF RHEUMATOID ARTHRITIS PATIENTS, TREATED TO TARGET AT LOW DISEASE ACTIVITY: 17-YEARS FOLLOW-UP OF THE BEST COHORT (2020) (0)
SAT0096 Window or no window: earlier is better when treating rheumatoid arthritis (2018) (0)
013 IMPAIRMENT OF FUNCTION IS THE MAJOR DETERMINANT OF REDUCED HEALTH-RELATED QUALITY OF LIFE IN HAND OSTEOARTHRITIS PATIENTS IN SECONDARY CARE (2009) (0)
SAT0255 Clinical and Radiographic Outcomes at 2 Years and the Effect of TOCILIZUMAB Discontinuation following Sustained Remission in the Second and Third Year of the ACT-RAY Study (2014) (0)
Human cartilage glycoprotein-39 directed T-cell responses in health and arthritic diseases (2003) (0)
THU0008 Mast cells show a reprogrammed transcriptional signature following repeated igg stimulations (2017) (0)
FRI0303 Degree of synovitis on MRI is correlated with histological and macroscopic features of synovial tissue inflammation in knee osteoarthritis (2013) (0)
Assessment of global disease activity in RA by patients and physicians: differences across countries in the METEOR Database (2015) (0)
FRI0086 Before Clinically Detectable Arthritis Develops, ACPA-Positive and ACPA-Negative Arthralgia Patients Have Different Symptoms (2016) (0)
Autoantibodies to GPI are predominantly present in extra-articular complications of human rheumatoid arthritis (2003) (0)
Discovery of distinctive gene expression profiles in human arthritides by cDNA micro-array analysis (2002) (0)
OP0091 What is the Evidence for the Presence of a Therapeutic Window of Opportunity in Rheumatoid Arthritis? A Systematic Literature Review (2013) (0)
FRI0084 Autopsy reports of the cerebrum of 24 patients with sle in the period 1988–99 (2001) (0)
OP0089 Genetic studies on DICKKOPF-1, sclerostin and the severity of joint destruction in rheumatoid arthritis (2013) (0)
OP0221 Is Site of Back Pain Related to Location of Inflammatory Lesions on MRI in Patients with Chronic Back Pain? (2013) (0)
P1473 Detection of cardiac sources of cerebrovascular events in patient with systemic lupus erythematosus with neuropsychiatric manifestations (2020) (0)
Local Swelling and Prolonged Local Pain in a Large Joint Are Independent Predictors of Damage in That Joint in Recent Onset Rheumatoid Arthritis Patients (2011) (0)
Can Anti-Cyclic Citrullinated Peptide Antibody Negative Rheumatoid Arthritis Be Subdivided in Clinical Subphenotypes? (2011) (0)
THU0327 EFFECT OF IMMUNOSUPPRESSIVE MEDICATION ON GASTRO-INTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS STRATIFIED FOR DISEASE DURATION. (2020) (0)
OP0313 Molecular analysis of anti-citrullinated protein antibody variable regions indicates aberrant selection processes during acpa b-cell development (2018) (0)
Adenoviral gene transfer of tissue inhibitors of metalloproteinases (TIMPs) reduces the invasive behaviour of rheumatoid fibroblast-like synovicytes (2001) (0)
OP0145 Gene-environment and disease interactions: is it smart to use cohort studies? (2001) (0)
A gene–environment interaction between HLA SE alleles and smoking affects the reactivity of ACPA to various citrullinated antigens (2010) (0)
SAT0030 Breach of autoreactive b-cell tolerance by post-translationally modified foreign proteins (2017) (0)
Molecular basis for the increased susceptibility of Indigenous North American tribes to seropositive rheumatoid arthritis (2016) (0)
THU0100 Disease Activity Flares in Early Rheumatoid Arthritis Patients are Associated with Joint Damage Progression and Disability – Analysis of 10 Year Follow-up in the Best Study (2015) (0)
THU0413 Normalisation of nailfold microvasculature after hematopoietic stem cell transplantation in severe systemic sclerosis (2018) (0)
Case Number 27: Jaw claudication in Takayasu’s disease (2003) (0)
A4.3 Adipocytes Modulate the Phenotype of Macrophages through Secreted Lipids (2013) (0)
THU0031 Anti-Carbamylated Protein Antibodies (Anti-CarP) Precede the Onset of Rheumatoid Arthritis (2013) (0)
and osteoarthritis arthritis, from patients with joint injury, inflammatory MMP protein and activity levels in synovial fluid (2006) (0)
A polymorphism in the IL-10 promoter affects autoantibody production and subsequent joint destruction in rheumatoid arthritis (2003) (0)
SAT0411 A spondyloarthritis research consortium of canada (SPARCC)-score cut-off ≥3 as best match for the ASAS definition of a positive MRI of the sacroiliac joints (2013) (0)
Difference in Clinical Presentation of Patients with Spondyloarthritis with a Positive MRI of the SI Joints and/or HLA-B27 Positivity (2011) (0)
THU0024 Treatment with immune checkpoint inhibitors and the break of b-cell tolerance to autoantigens (2018) (0)
AB0084 Breadth of baseline autoantibody profile and treatment response in rheumatoid arthritis patients (2017) (0)
Gene expression profiling provides a link between high inflammatory synovitis and myofibroblast-like synoviocytes (2005) (0)
OP0302 Significant reductions of pathogenic autoantibodies by synergetic rituximab and belimumab treatment effectively inhibits neutrophil extracellular traps in severe, refractory sle - the synbiose study (2017) (0)
AB0383 EXTREME FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND NEUROPSYCHIATRIC SYMPTOMS (2020) (0)
SAT0350 Does a systemic sclerosis patient's clinical phenotype demonstrate his autoantibody status? (2017) (0)
Factors influencing adenoviral gene transfer (2001) (0)
FRI0318 Mortality in osteoarthritis patients consulting health care (2013) (0)
Molecular analysis of gene-polymorphisms affecting the host response to infection. (2001) (0)
Role of IL-10 as a susceptibility factor for rheumatoid arthritis and cardiovascular disease (2005) (0)
SAT0082 Evaluation of definitions of rheumatoid arthritis remission by assessing radiographic progression in the leiden early arthritis cohort (2013) (0)
Association of the CD226 (DNAM-1) Gly307Ser polymorphism with juvenile idiopathic arthritis (2011) (0)
AB0086 Anti-Citrullinated Protein Antibodies in Patients with Cardiovascular Disease without RA (2016) (0)
Fibroblast-like synoviocytes from RA patients exploit a tumor-specific apoptosis pathway whereas synoviocytes from controls do not. (2002) (0)
P4440Assessment of left atrial function in patients with systemic lupus erythematosus with and without neuropsychiatric manifestations: association with cardiovascular events (2019) (0)
SAT0262 Should Imaging of the SI Joints be Repeated After 1 Year? Impact on the Classification of Patients According to the ASAS Axial SPA Criteria (2015) (0)
FRI0272 How much does the spondyloarthritis research consortium of canada (SPARCC)-score of the SI-joints change over a 3-month period in patients on non-biological treatment? (2013) (0)
P007 In ra, becoming seronegative over the 1st year of dmard treatment does not translate to better chances of drug-free remission in the long-term (2018) (0)
OP0194 Dna Methylation in Relation to Arthritis Persistency: an Epigenome Wide-Study (2014) (0)
OP0224 Similar short term clinical response to initial treatment with high versus low dose methotrexate in mono- and combination therapy in early rheumatoid arthritis patients (2017) (0)
OP0049 A Genetic Variant in the Region of MMP-9 is Associated with Serum Levels and Progression of Joint Damage in Rheumatoid Arthritis (2013) (0)
Rheumatoid arthritis: a heterogeneous disease evaluated by DNA-microarray technology (2004) (0)
087 IMPLEMENTATION OF A SCID ENGRAFTMENT MODEL WITH SYNOVIAL FIBROBLASTS AND CARTILAGE TO CHARACTERIZE OA PATIENTS (2009) (0)
Association between TNF -308A and systemic lupus erythematosus in relation to HLA-DR3 and six microsatellite markers on the short arm of chromosome VI (2001) (0)
Altered composition of CD97 splice variants in rheumatoid synovial tissue (2005) (0)
AB0988 Inflammation in hand osteoarthritis remains constant after a period of 3 months (2013) (0)
Pro-MMP levels and severity of RA (2003) (0)
Unusual and memorable.... Case number 27: Jaw claudication in Takayasu's disease (2003) (0)
OP0018 Early treatment of recent-onset rheumatoid arthritis patients impairs the effect of hla class ii antigens on the progression of joint destruction (2001) (0)
OP0193 Motivations for seeking medical advice in arthralgia and early arthritis patients (2013) (0)
OP0032 Invasion of synoviocytes is inhibited by gene transfer of tnf-bp or il10 in an in vitro invasion model (2001) (0)
FRI0383 Changes in white matter microstructure correlate with sf-36 mental component subscore in inflammatory npsle (2018) (0)
The Effect of Rituximab on B Cells in Skin and Peripheral Blood in Systemic Sclerosis (2016) (0)
P051/O01 Characterization of the anti-centromere antibody response in systemic sclerosis patients suggests a broad and active B cell response (2019) (0)
FRI0186 Impact of Concomitant Methotrexate Dose on the Efficacy and Safety of Sarilumab for Treatment of Moderate-to-Severe Rheumatoid Arthritis: The Mobility Study (2015) (0)
AB0749 Don’t forget the caregivers of patients with systemic sclerosis (2018) (0)
AB0022 AUTOREACTIVE B CELLS IN RHEUMATOID ARTHRITIS DISPLAY AN ACTIVATED PHENOTYPE OF RECENT ANTIGEN EXPOSURE (2021) (0)
SAT0218 Clinical phenotypes in NPSLE; data from the leiden NPSLE clinic (2013) (0)
SAT0310 ANTI-CENTROMERE ANTIBODY ISOTYPE LEVELS AS BIOMARKER FOR DISEASE PROGRESSION IN SUBJECTS AT RISK TO DEVELOP SYSTEMIC SCLEROSIS (2020) (0)
A6.22 Specialised pro-resolving lipid mediators in chronic inflammation: a comparison between rheumatoid arthritis and osteoarthritis (2015) (0)
FRI0207 Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate, methotrexate alone or placebo: the dinora trial (2017) (0)
FRI0554 Young Patients with Back Pain and Maximally 1 Spondyloarthritis Feature: Is it Necessary to Test HLA-B27 or Image the Sacroiliac Joints? (2015) (0)
AB1096 Local Radiologists Score More Abnormalities in Comparison to Central Readers Leading to More Patients Fulfilling the Classification Criteria of Axial Spa: Data from the Space-Cohort (2015) (0)
Off-Label Use Of Rituximab For Systemic Lupus Erythematosus in Europe: Limited Use Mostly In Refractory Patients (2013) (0)
NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS. AUTHORS' REPLY (1999) (0)
AB0720 Performance of Referral Parameters of Patients with Chronic Back Pain Included in the Spondyloarthritis Caught Early Cohort (SPACE) (2014) (0)
Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor (1999) (0)
Is Site Of Back Pain Related To Location Of Inflammatory and Structural Lesions On MRI In Patients With Chronic Back Pain (2013) (0)
Infrapatellar fat pad from osteoarthritis patients displays a distinctive eicosanoid release profile compared to healthy donors (2012) (0)
The ACPA Recognition Profile and Sub-Grouping of APCA Positive Rheumatoid Arthritis Patients. (2011) (0)
AB0705 Psychopathologic Involvement in Systemic Sclerosis: A Pilot Study (2015) (0)
High Body Mass Index Is Associated with Decreased Response to Initial Combination Therapy in Recent Onset RA Patients. (2012) (0)
Towards personalized treatment: predictors of short term HAQ response in recent onset active RA are different from predictors of rapid radiological progression (2012) (0)
Genetic variants of C1q are a risk for rheumatoid arthritis (2012) (0)
SAT0104 MAINTENANCE OF SDAI REMISSION AND PATIENT-REPORTED OUTCOMES (PROS) FOLLOWING DOSE DE-ESCALATION OF ABATACEPT IN MTX-NAÏVE, ANTI-CITRULLINATED PROTEIN ANTIBODY (ACPA)+ PATIENTS WITH EARLY RA: RESULTS FROM AVERT-2, A RANDOMISED PHASE IIIB STUDY (2020) (0)
SAT0028 The importance of proper handling of human synovial fluid for arthritis research (2018) (0)

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Leiden University

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