Tyler Jacks
#27,669
Most Influential Person Now
American biologist
Tyler Jacks's AcademicInfluence.com Rankings
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Biology
Tyler Jacks's Degrees
- PhD Biology University of California, San Francisco
- Bachelors Biology University of California, Santa Cruz
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Why Is Tyler Jacks Influential?
(Suggest an Edit or Addition)According to Wikipedia, Tyler Jacks is a David H. Koch Professor of Biology at the Massachusetts Institute of Technology , a long-time HHMI investigator, and Founding Director of the David H. Koch Institute for Integrative Cancer Research, which brings together biologists and engineers to improve detection, diagnosis, and treatment of cancer. Dr. Jacks is a member of the board of directors of Thermo Fisher Scientific and Amgen, two of the major biotechnology corporations in the world. He is the President of Break Through Cancer, a foundation dedicated to supporting multi-institutional teams of researchers focused on finding solutions to some of the most difficult to treat cancers. He is also a member of the Board of Overseers, the larger of two governing boards of Harvard University.
Tyler Jacks's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- MicroRNA expression profiles classify human cancers (2005) (9561)
- Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009) (3820)
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia (1992) (3220)
- p53-dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) (3193)
- p53 is required for radiation-induced apoptosis in mouse thymocytes (1993) (3062)
- Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours (1996) (2431)
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009) (2300)
- Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. (2003) (2209)
- Tumor spectrum analysis in p53-mutant mice (1994) (2115)
- Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer (2005) (2101)
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response (2010) (1942)
- Effects of an Rb mutation in the mouse (1992) (1877)
- Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. (2001) (1795)
- Restoration of p53 function leads to tumour regression in vivo (2007) (1737)
- p53 status and the efficacy of cancer therapy in vivo. (1994) (1642)
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters (2008) (1578)
- Impaired microRNA processing enhances cellular transformation and tumorigenesis (2007) (1531)
- Sunburn and p53 in the onset of skin cancer (1994) (1517)
- Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53 (1992) (1396)
- Radiation-induced cell cycle arrest compromised by p21 deficiency (1995) (1356)
- Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome (2004) (1220)
- Somatic activation of the K-ras oncogene causes early onset lung cancer in mice (2001) (1151)
- p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. (1995) (1140)
- Treating metastatic cancer with nanotechnology (2011) (994)
- p53-Dependent apoptosis suppresses tumor growth and progression in vivo (1994) (985)
- Characterization of ribosomal frameshifting in HIV-1 gag-pol expression (1988) (956)
- MicroRNAs and Cancer: Short RNAs Go a Long Way (2009) (904)
- Suppression of non-small cell lung tumor development by the let-7 microRNA family (2008) (899)
- p63 and p73 are required for p53-dependent apoptosis in response to DNA damage (2002) (882)
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype (2014) (841)
- Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. (2004) (807)
- Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 (1996) (797)
- Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 (1994) (747)
- DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 (1994) (707)
- Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase (2009) (698)
- STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications (2001) (696)
- Role for the p53 homologue p73 in E2F-1-induced apoptosis (2000) (674)
- Cre-lox-regulated conditional RNA interference from transgenes. (2004) (660)
- p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens (1994) (653)
- CRISPR-mediated direct mutation of cancer genes in the mouse liver (2014) (636)
- Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. (2000) (633)
- A subset of p53-deficient embryos exhibit exencephaly (1995) (620)
- KRAS and YAP1 Converge to Regulate EMT and Tumor Survival (2014) (613)
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer (2005) (591)
- Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region (1988) (580)
- NF1 Tumor Suppressor Gene Function Narrowing the GAP (2001) (578)
- Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 (2002) (578)
- K-ras is an essential gene in the mouse with partial functional overlap with N-ras. (1997) (574)
- Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells (1996) (572)
- Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry (2003) (566)
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. (2016) (563)
- Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon (2008) (560)
- Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. (2005) (548)
- Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells (2009) (546)
- Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma (2009) (535)
- Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption (1998) (528)
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. (2013) (516)
- AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. (2009) (510)
- The differential effects of mutant p53 alleles on advanced murine lung cancer. (2005) (496)
- Expression of tumour-specific antigens underlies cancer immunoediting (2011) (470)
- Shared role of the pRB-related p130 and p107 proteins in limb development. (1996) (470)
- Mouse models of tumor development in neurofibromatosis type 1. (1999) (466)
- Dicer1 functions as a haploinsufficient tumor suppressor. (2009) (463)
- The retinoblastoma gene family in differentiation and development (1999) (453)
- Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. (1985) (441)
- Commensal Microbiota Promote Lung Cancer Development via γδ T Cells (2019) (431)
- PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells (2013) (430)
- Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression (2008) (426)
- An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis (2005) (421)
- Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. (1998) (418)
- Autophagy is required for glucose homeostasis and lung tumor maintenance. (2014) (416)
- MHC-II neoantigens shape tumor immunity and response to immunotherapy (2019) (413)
- PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. (2000) (411)
- Suppression of Lung Adenocarcinoma Progression by Nkx2-1 (2011) (408)
- Cooperative tumorigenic effects of germline mutations in Rb and p53 (1994) (405)
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers (2016) (403)
- Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects (2000) (401)
- Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. (1998) (392)
- LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. (2014) (385)
- Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis (2017) (376)
- Cancer Modeling in the Modern Era Progress and Challenges (2002) (373)
- Targeted disruption of p107: functional overlap between p107 and Rb. (1996) (367)
- The retinoblastoma gene family: cousins with overlapping interests. (1998) (367)
- Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein (1995) (364)
- Loss of Rb activates both p53‐dependent and independent cell death pathways in the developing mouse nervous system. (1996) (361)
- p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. (1994) (358)
- An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 (2000) (348)
- The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. (2001) (346)
- Applications of the CRISPR–Cas9 system in cancer biology (2015) (339)
- Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice (1998) (334)
- Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle (1996) (334)
- Cell cycle-specific association of E2F with the p130 E1A-binding protein. (1993) (333)
- Single-molecule transcript counting of stem-cell markers in the mouse intestine (2011) (330)
- Extensive contribution of Rb‐deficient cells to adult chimeric mice with limited histopathological consequences. (1994) (323)
- Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. (1994) (322)
- Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. (2004) (321)
- Classification of Proliferative Pulmonary Lesions of the Mouse (2004) (321)
- Circadian Rhythm Disruption Promotes Lung Tumorigenesis. (2016) (315)
- Rapid modeling of cooperating genetic events in cancer through somatic genome editing (2014) (314)
- Taking the Study of Cancer Cell Survival to a New Dimension (2002) (313)
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma (2015) (311)
- Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts (1996) (311)
- PKM2, cancer metabolism, and the road ahead (2016) (309)
- The cell cycle and cancer. (1997) (304)
- Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. (2009) (302)
- A mouse model for the learning and memory deficits associated with neurofibromatosis type I (1997) (301)
- Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. (2015) (300)
- A spatially and temporally restricted mouse model of soft tissue sarcoma (2007) (292)
- Wildtype Kras2 can inhibit lung carcinogenesis in mice (2001) (286)
- Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. (1999) (285)
- Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. (2004) (283)
- Cell-cycle control and its watchman (1996) (280)
- Characterizing deformability and surface friction of cancer cells (2013) (278)
- For better or for worse. (1991) (262)
- Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis. (1996) (260)
- Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. (1993) (259)
- Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 (2017) (258)
- Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization* (2002) (254)
- Stage-specific sensitivity to p53 restoration during lung cancer progression (2010) (254)
- Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. (2003) (242)
- A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma (2017) (241)
- Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing (2014) (227)
- Cell type-specific effects of Rb deletion in the murine retina. (2004) (225)
- The role of p53 in tumour suppression: lessons from mouse models (1999) (224)
- Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function (2002) (215)
- p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis (2009) (213)
- Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress (2011) (208)
- The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. (1997) (205)
- Small RNA combination therapy for lung cancer (2014) (203)
- Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. (2013) (196)
- Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. (2011) (196)
- A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies (2019) (195)
- Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. (1993) (194)
- RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. (1998) (193)
- Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. (2010) (191)
- Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1 (2003) (190)
- Mutations in the p53 and SCID genes cooperate in tumorigenesis. (1996) (186)
- Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis (2016) (185)
- Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy (2010) (185)
- p53-independent apoptosis induced by paclitaxel through an indirect mechanism. (1997) (177)
- Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. (1987) (176)
- Requirement for Rac1 in a K-ras induced lung cancer in the mouse. (2007) (175)
- In vivo genome editing and organoid transplantation models of colorectal cancer (2017) (168)
- Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines (1998) (167)
- A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis (2012) (167)
- Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. (2000) (163)
- p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells (1998) (162)
- Control of CpNpG DNA methylation by the KRYPTONITE histone H 3 methyltransferase (2002) (159)
- A physical sciences network characterization of non-tumorigenic and metastatic cells (2013) (157)
- Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System (2003) (156)
- Insights into cancer from transgenic mouse models (1999) (156)
- Mammalian RNAi: a practical guide. (2005) (156)
- ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. (2006) (150)
- Optimality in the Development of Intestinal Crypts (2012) (149)
- Nf1 and Gmcsf interact in myeloid leukemogenesis. (2000) (147)
- Nuclear factor I/B is an oncogene in small cell lung cancer. (2011) (147)
- p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. (1998) (145)
- p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair (2009) (145)
- Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. (2005) (145)
- Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23 (2004) (139)
- Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli* (1998) (139)
- Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. (2020) (138)
- Modeling human lung cancer in mice: similarities and shortcomings (1999) (138)
- Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules (1993) (137)
- Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. (2003) (135)
- Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389 (2004) (134)
- Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. (2011) (134)
- Translational suppression in gene expression in retroviruses and retrotransposons. (1990) (132)
- Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. (2006) (130)
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. (2007) (129)
- Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. (2011) (128)
- HIF-2α deletion promotes Kras-driven lung tumor development (2010) (127)
- Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma (2016) (127)
- For Better or Worse? Telomerase Inhibition and Cancer (1999) (125)
- Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (125)
- Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. (2011) (123)
- Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer (2004) (122)
- p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer (2014) (121)
- Survival of pancreatic cancer cells lacking KRAS function (2017) (119)
- Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue. (2000) (118)
- Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types (2003) (118)
- Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma (2016) (117)
- Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo (2003) (116)
- Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. (2015) (113)
- The Expanding Role of Cell Cycle Regulators (1998) (111)
- Tumor suppressor gene mutations in mice. (1999) (110)
- Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. (2011) (107)
- The Rb tumor suppressor is required for stress erythropoiesis (2004) (107)
- Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. (2008) (105)
- Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer (2015) (104)
- Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm−/− Mice (1998) (103)
- RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. (2004) (103)
- An Induced Ets Repressor Complex Regulates Growth Arrest during Terminal Macrophage Differentiation (2002) (103)
- Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation (2011) (102)
- Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival (2017) (102)
- Cell‐autonomous and non‐cell‐autonomous functions of the Rb tumor suppressor in developing central nervous system (2001) (102)
- Double indemnity: p53, BRCA and cancer (1997) (101)
- Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. (2004) (96)
- Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer (2021) (95)
- Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. (2014) (93)
- Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. (2020) (93)
- Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis (2015) (91)
- A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. (2013) (89)
- Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. (1996) (89)
- The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung (2015) (89)
- Technologically advanced cancer modeling in mice. (2002) (84)
- Progesterone receptor expression in neurofibromas. (2003) (82)
- Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis. (2011) (80)
- Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap (1997) (80)
- In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. (1999) (80)
- p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB (1998) (79)
- Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas (2010) (77)
- The Related Retinoblastoma (pRb) and p130 Proteins Cooperate to Regulate Homeostasis in the Intestinal Epithelium* (2006) (77)
- Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma (2009) (77)
- Complete deletion of Apc results in severe polyposis in mice (2009) (76)
- Expression of cyclins E1 and E2 during mouse development and in neoplasia (2001) (75)
- ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos (2002) (74)
- Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. (2005) (74)
- A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice (2006) (71)
- Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. (2006) (71)
- The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer (2020) (70)
- Murine bilateral retinoblastoma exhibiting rapid‐onset, metastatic progression and N‐myc gene amplification (2007) (70)
- Identification of DHODH as a therapeutic target in small cell lung cancer (2019) (70)
- V(D)J recombination is not required for the development of lymphoma in p53-deficient mice. (1998) (68)
- Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response. (2013) (67)
- Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. (2012) (67)
- Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) (64)
- Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. (2010) (62)
- The Nf2 tumor suppressor regulates cell–cell adhesion during tissue fusion (2007) (62)
- Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation (2018) (62)
- Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma (2019) (60)
- Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. (2013) (59)
- Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. (2013) (59)
- Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras (2010) (57)
- Spatial genomics enables multi-modal study of clonal heterogeneity in tissues (2021) (57)
- Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. (1995) (57)
- Mouse models of human non-small-cell lung cancer: raising the bar. (2005) (57)
- Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. (1997) (55)
- Multiple response elements and differential p53 binding control Perp expression during apoptosis. (2003) (54)
- Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. (1998) (54)
- Myeloid malignancies induced by alkylating agents in Nf1 mice. (1999) (54)
- Imaging primary lung cancers in mice to study radiation biology. (2010) (54)
- Therapy-induced malignant neoplasms in Nf1 mutant mice. (2005) (53)
- Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers (2016) (52)
- Rb and N-ras Function Together To Control Differentiation in the Mouse (2003) (52)
- Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene (2002) (52)
- A versatile reporter system for CRISPR-mediated chromosomal rearrangements (2015) (51)
- A big step in the study of small cell lung cancer. (2003) (51)
- The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. (2021) (51)
- Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (2005) (51)
- Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. (2007) (50)
- p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage (2007) (49)
- A U.S. “Cancer Moonshot” to accelerate cancer research (2016) (49)
- Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. (2008) (47)
- Comparison of gene expression and DNA copy number changes in a murine model of lung cancer (2006) (47)
- A Modular Assembly Platform for Rapid Generation of DNA Constructs (2016) (47)
- Apoptosis and the prognostic significance of p53 mutation. (1994) (46)
- ARF mutation accelerates pituitary tumor development in Rb+/− mice (2002) (46)
- A mouse model for the learning and memory deficits associated with neurofibromatosis type I (2002) (46)
- Characterization of pheochromocytomas in a mouse strain with a targeted disruptive mutation of the neurofibromatosis gene Nf1 (1995) (45)
- Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. (2006) (45)
- p53 and treatment of bladder cancer (1997) (45)
- Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents (2004) (44)
- Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. (2021) (42)
- Strategies to achieve conditional gene mutation in mice. (2014) (42)
- Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation (2019) (41)
- Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. (2009) (41)
- IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. (2019) (41)
- Genetic and cellular mechanisms of oncogenesis. (2008) (40)
- Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling (2020) (40)
- Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair. (1997) (40)
- Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer (2019) (38)
- iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer (2018) (38)
- PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes (2017) (37)
- Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution (2022) (37)
- CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer (2019) (37)
- Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors (2021) (37)
- Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas. (2005) (36)
- Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment (2022) (35)
- Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS: gelsolin complex (2007) (35)
- Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells (1993) (35)
- Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads (2021) (35)
- Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. (2013) (34)
- Genetically engineered mouse models of astrocytoma: GEMs in the rough? (2001) (33)
- Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells. (2018) (33)
- Enhanced cell survival and tumorigenesis. (1994) (32)
- Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation. (2003) (31)
- SnapShot: Lung Cancer Models (2012) (31)
- Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment (2020) (29)
- Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 (2020) (29)
- Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment. (2002) (29)
- Recombinase-based conditional and reversible gene regulation via XTR alleles (2015) (29)
- Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer (2021) (28)
- Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis (2017) (28)
- Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. (2007) (28)
- Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation (2019) (28)
- Neurofibromatosis and related tumors. Natural occurrence and animal models. (1994) (28)
- The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma. (2014) (27)
- Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer. (2002) (27)
- Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein (2002) (26)
- Guilty by Association (2013) (26)
- Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma (2020) (25)
- Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin‐LGK974 inclusion complexes (2018) (25)
- p53-dependent apoptosis in vivo: impact of p53 inactivation on tumorigenesis. (1994) (25)
- Erratum: Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium (Cancer Research (April 1, 2004) 64 (2307-2316)) (2004) (24)
- Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis (2018) (24)
- The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain (2021) (24)
- A mouse plasma peptide atlas as a resource for disease proteomics (2008) (23)
- SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. (2021) (23)
- Progressive Genomic Instability in the FVB/KrasLA2 Mouse Model of Lung Cancer (2011) (22)
- Coordinate Loss of a MicroRNA Mir 145 and a Protein-Coding Gene RPS14 Cooperate in the Pathogenesis of 5q- Syndrome. (2009) (22)
- The CD155/TIGIT Axis Promotes and Maintains Immune Evasion in Neoantigen-Expressing Pancreatic Cancer (2020) (22)
- NF-κB Fans the Flames of Lung Carcinogenesis (2010) (22)
- Mechanisms of carcinogenesis and the mutant mouse. (1996) (21)
- Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma (2018) (21)
- Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma (2020) (21)
- Future of Early Detection of Lung Cancer: The Role of Mouse Models (2005) (21)
- Inducible de novo expression of neoantigens in tumor cells and mice with NINJA (2020) (20)
- Mist 1-KrasG 12 D KnockIn Mice Develop Mixed Differentiation Metastatic Exocrine Pancreatic Carcinoma and Hepatocellular Carcinoma (2005) (20)
- Genome editing with Cas 9 in adult mice corrects a disease mutation and phenotype Citation (2014) (19)
- The cancer cell and the cell cycle clock. (1994) (19)
- BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency (2020) (19)
- Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality (1997) (18)
- Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation (2005) (18)
- Whole-mount X-Gal staining of mouse tissues. (2014) (18)
- Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin. (2002) (17)
- Tumor suppressor mutations in mice: the next generation. (1998) (17)
- Lessons from the p53 mutant mouse. (1996) (17)
- Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice (2004) (17)
- MHC-II neoantigens shape tumour immunity and response to immunotherapy (2019) (17)
- Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer. (2018) (16)
- Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. (2022) (16)
- Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration (2021) (16)
- Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family (2017) (15)
- Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53. (1994) (15)
- Capitalizing on convergence for health care (2016) (15)
- Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes (2021) (14)
- Increased generation of CD8+ T cell clones in p53 mutant mice. (1999) (14)
- LBA1 Mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: Towards molecular cancer prevention (2022) (14)
- The cell cycle and cancer (1997) (13)
- Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. (2007) (12)
- Deciphering the immunopeptidome in vivo reveals new tumour antigens (2022) (12)
- Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice (2020) (12)
- Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic KRas Citation (2009) (11)
- Cell multiplication. Peering in and peering out: regulation of and by the cell cycle. (1999) (11)
- Supplementary Notes MicroRNA Expression Profiles Classify Human Cancers (2005) (11)
- Nf1 gene targeting: toward models and mechanisms. (1996) (10)
- Seminars in Cancer Biology: Introduction (2001) (10)
- In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. (2014) (9)
- Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer (2020) (8)
- A bumper crop of cancer genes (1999) (8)
- Erratum: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse (Cancer Cell (4) (437-450)) (2004) (8)
- Germline loss of PKM 2 promotes metabolic distress and hepatocellular carcinoma (2016) (8)
- Rlf-Mycl gene fusion drives tumorigenesis and metastasis in a mouse model of small cell lung cancer. (2021) (7)
- Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution (2021) (7)
- Corrigendum: Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells (1996) (7)
- evidence of strain-specific effects (2000) (7)
- Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype (2014) (7)
- The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer (2020) (6)
- KRAS and YAP 1 Converge to Regulate EMT and Tumor Survival Citation (2014) (6)
- Lessons from thep53 mutant mouse (2005) (6)
- A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. (2014) (6)
- Modeling cancer in the mouse. (2005) (6)
- Producing and concentrating lenti-Cre for mouse infections. (2014) (6)
- Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma (2021) (6)
- Introduction. The laboratory mouse in cancer research. (2001) (5)
- P53 and Treatment of Bladder-Cancer - Reply (1997) (5)
- Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection (2021) (5)
- Targeted disruption of pi07: functional overlap between pl07 and Rb (1996) (5)
- Multiscale profiling of protease activity in cancer (2022) (4)
- Mismatch repair deficiency is not sufficient to increase tumor immunogenicity (2021) (4)
- Murine Lung Cancer Alleles on Advanced p 53 The Differential Effects of Mutant Updated (2005) (4)
- Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform (2021) (4)
- p53 Family Members: p63 and p73 (2005) (4)
- Noninvasive lung cancer detection via pulmonary protease profiling (2018) (3)
- PMP-22 / gas 3 family PERP , an apoptosis-associated target of p 53 , is a novel member of the (2000) (3)
- Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression (2019) (3)
- Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER 1 Citation (2012) (3)
- Multiscale profiling of enzyme activity in cancer (2021) (3)
- Neurofibromatosis type 1. (2003) (3)
- Lung adenocarcinoma promotion by air pollutants (2023) (3)
- A mouse model for soft tissue sarcoma. (2005) (2)
- TAMI-08. THE CCL2-CCR2 ASTROCYTE-CANCER CELL AXIS IN TUMOR EXTRAVASATION AT THE BRAIN (2021) (2)
- Chapter 9 – Genetic Mouse Models of Cancer (2008) (2)
- Introductory comments (1999) (2)
- Driving Rel-iant Tregs toward an Identity Crisis. (2017) (2)
- Expression of oncogenic Kras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways (2007) (2)
- Using Mouse Genetics to Dissect the Cellular Target of Radiation in the GI Syndrome (2005) (2)
- Inducible de novo expression of neoantigens in tumor cells and mice (2020) (2)
- MicroRNAs: Roles of microRNAs in cancer and development (2007) (2)
- The mutational landscape of EGFR-, MYC-, and Kras- driven genetically-engineered mouse models of lung adenocarcinoma (2016) (2)
- Abstract A24: Using single-cell RNA-seq approaches to decipher heterogeneity in autochthonous mouse models of small cell lung cancer (2018) (2)
- Abstract 2957: Uncovering tumor-specific components of the p53 pathway using mouse models and RNAi (2012) (2)
- Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models (2021) (1)
- Engineered Mouse Models of Epithelial Ovarian Cancer Cyclooxygenase-1 Is Overexpressed in Multiple Genetically (2006) (1)
- Abstract #3822: PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA- mutant cancers (2009) (1)
- Hypoxia in a tumor may promote emergence of clones with p53 gene mutation (1996) (1)
- Targeting cancer: an interview with Tyler Jacks. Interview by Kathy Weston. (2010) (1)
- Author response: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma (2020) (1)
- Spatially-Resolved Live Cell Tagging and Isolation Using Protected Photoactivatable Cell Dyes (2020) (1)
- Abstract PR-007: Single-nucleus and spatial transcriptomics of archival pancreatic ductal adenocarcinoma reveals multi-compartment reprogramming after neoadjuvant treatment (2020) (1)
- Abrogation of oncogene-associated apoptosis allows transformation of p 53-deficient cells ( tumor suppressor gene / adfovrs ElA / adenovirus E 1 B ) (1)
- Basic Mouse Methods for Clinician Researchers (2016) (1)
- Tissue-specific p19[superscript Arf] regulation dictates the response to oncogenic K-ras (2010) (1)
- Abstract 3992: Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing (2014) (1)
- Abstract LB-284: Engineering a hypermutant mouse model of NSCLC to modulate immune response (2018) (1)
- The beginning of the end of frustration. (2005) (1)
- Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer. (2018) (1)
- 2685: Utilizing Mouse Genetics to Dissect the Cellular Target and Molecular Mechanism of Acute and Late Toxicity of Abdominal Radiation Therapy (2006) (1)
- Abstract A63: Commensal microbiota promote lung tumorigenesis via γδ T cells (2020) (1)
- Microenvironmental adaptations drive obesity-associated pancreatic cancer (2019) (1)
- Abstract PR04: Germline loss of PK-M2 promotes metabolic syndrome and hepatocellular carcinoma (2016) (1)
- Abstract A12: CRISPR-mediated modeling and functional validation of candidate tumor-suppressor genes in small cell lung cancer (2018) (1)
- Single-nucleus RNA-seq and Spatial Transcriptomics of Archival Primary Pancreatic Ductal Adenocarcinoma Uncovers Multi-compartment Intratumoral Heterogeneity Associated with Neoadjuvant Chemoradiotherapy (2020) (1)
- Progesterone Receptor Expression in Neurofibromas 1 (2003) (0)
- Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction. (2013) (0)
- Abstract 1511: A highly plastic cell state emerges during lung adenocarcinoma evolution (2020) (0)
- Abstract PR14: Preclinical models to dissect immune escape in pancreatic cancer (2019) (0)
- “Studying Tumor Progression and Treatment Resistance Using Focused Re- sequencing of High-value Gene Sets in Mouse Models of Human Lung (2008) (0)
- Expression of antigens underlies cancer immunoediting. (2016) (0)
- IMPAIRED SHP2-MEDIATED ERK ACTIVATION CONTRIBUTES TO GEFITINIB SENSITIVITY OF LUNG CANCER CELLS WITH EGFR-ACTIVATING MUTATIONS (2010) (0)
- Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes (2021) (0)
- Abstract 2194: Rapid interrogation of colon cancer driver genes in vivo using split Cre and CRISPR-Cas9 (2022) (0)
- Abstract LB-146: Identification of copy number alterations in small cell lung cancer (2010) (0)
- Abstract 5018: Dissecting antigen-specific T-cell response in a novel mouse model of colon cancer (2017) (0)
- Abstract 1785: NF2 Plays Detrimental Roles through Mst1 against Pressure Overload (PO) in the Heart (2008) (0)
- A versatile reporter system for CRISPR-mediated chromosomal rearrangements (2015) (0)
- Cancer Genes and Genomics Progressive Genomic Instability in the FVB / KrasLA 2 Mouse Model of Lung Cancer (2011) (0)
- SH3PXD2A (SH3 and PX domains 2A) (2017) (0)
- Abstract 4091: Knockout of genes in the DNA mismatch repair pathway to model colorectal cancer hypermutation (2018) (0)
- Abstract A44: The role of PHF6 in maintaining pre-B cell commitment in B-cell acute lymphoblastic leukemia (2016) (0)
- 195 NF-κB signaling is essential in lung adenocarcinoma (2008) (0)
- Spatial genomics enables multi-modal study of clonal heterogeneity in tissues (2021) (0)
- Targets of the p53-related transcription factors (2001) (0)
- Anti-Tumor TCF1+ CD8 T Cells are Functionally Diverse and Evolve During Tumorigenesis and Progression (2020) (0)
- Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (0)
- Abstract A85: Investigating endogenous anti-tumor T cell responses in native tumor microenvironments (2017) (0)
- Abstract IA17: The role of the senescence-associated secretory phenotype in cancer (2021) (0)
- Chapter 4 Lack of p 53 . S 389 phosphorylation predisposes mice to develop 2-acetylaminoflurene-induced bladder tumors but not ionizing radiation-induced lymphomas (2007) (0)
- Abstract 2973: Adhesion of tumor cells to ECM microarrays identifies novel ECM interactions in metastasis (2012) (0)
- Abstract IA34: Targeting cellular heterogeneity in lung adenocarcinoma (2018) (0)
- Abstract A22: Molecular subtypes and resistance programs in pancreatic ductal adenocarcinoma elucidated with single-nucleus RNA-seq (2019) (0)
- Modeling natural killer cell responses against lung cancer (TUM2P.917) (2014) (0)
- Natural Occurrence andAnimal Models (1994) (0)
- Conference Co-Chairpersons: (2002) (0)
- Biomarker discovery and preclinical validation using mouse models of lung cancer. (2006) (0)
- 14 Lung cancer progression (2010) (0)
- Abstract PR08: Leveraging single-cell epigenomics to uncover regulatory programs in lung adenocarcinoma (2020) (0)
- Abstract C014: Broadening the repertoire of PDAC-specific targets for immune-based therapy through high-resolution immunopeptidomics (2022) (0)
- Abstract 94: Multi-compartment reprogramming and spatially-resolved interactions in frozen pancreatic cancer with and without neoadjuvant chemotherapy and radiotherapy at single-cell resolution (2021) (0)
- Increased Dysfunction of Tumor Specific TCF-1+ CD8+ T Cells Associated with Increase in Non-Cycling TCF-1+ SlamF6- Cells Subsets Revealed by Single Cell Analysis (2020) (0)
- Abstract B39: Nkx2-1 down-regulation underlies lung adenocarcinoma progression towards malignancy (2009) (0)
- Abstract A66: Molecular profiling of regulatory T cells in a genetic mouse model of lung adenocarcinoma (2017) (0)
- Abstract SY12-04: Multicellular spatial community featuring a novel neuronal-like malignant phenotype is enriched in pancreatic cancer after neoadjuvant chemotherapy and radiotherapy (2022) (0)
- p53 dependnet sensitivity to radiation in a transplanted tumor model (1994) (0)
- invasion of lung adenocarcinoma isoform expression contributes to metastatic Tks 5 Differential Material Supplemental (2013) (0)
- Circadian Rhythm Disrupt ion Promotes Lung Tumorigenesis Graphical Abstract Highlights (2016) (0)
- Procedes in vivo de validation du role d'un gene d'entretien tumoral (2003) (0)
- Abstract PR02: The diverse roles of long noncoding RNAs in the p53 tumor suppressor pathway (2016) (0)
- 459 Loss of the MiR-200s in a Metastatic Model of Lung Adenocarcinoma Promotes Eps8 Mediated Cell Migration and Invasion (2012) (0)
- Abstract LB-151: Targeted gene resequencing in a K-ras-dependent mouse model of metastatic lung adenocarcinoma (2010) (0)
- Abstract LB-330: Endogenous T cell responses to lung adenocarcinoma neoantigens delay malignant tumor progression (2010) (0)
- Abstract 5877: Intratumoral lymphocyte networks harbor TCF1+ PD1+ progenitor CD8 T cells in lung cancer (2023) (0)
- Abstract 99: Wnt signaling promotes tumor propagation in a mouse model of lung adenocarcinoma (2014) (0)
- In Vitro Analysis of Myeloid Proliferation Caused by Oncogenic Kras. (2004) (0)
- For Better or Worse? Minireview Telomerase Inhibition and Cancer (1999) (0)
- Cell cycle-specific association of E2F with the p 130 E 1A-binding protein (2007) (0)
- Abstract 1124: Wnt-producing niche cells support cancer stem-like cells in pancreatic ductal adenocarcinoma (2018) (0)
- Abstract C052: Identifying mediators of perineural invasion in pancreatic cancer using spatial transcriptomics (2022) (0)
- Studies on the mechanism of cell growth suppression by the retinoblastoma gene (1990) (0)
- Abstract PR-006: Integrative genomic characterization of therapeutic targets for pancreatic cancer (2021) (0)
- Publisher Correction: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 (2020) (0)
- Expression oftheRousSarcoma Virus polGenebyRibosomal Frameshifting (2016) (0)
- Abstract IA-4: Studying tumor evolution in mouse models of cancer (2009) (0)
- Towards an animal model for retinoblastoma (1989) (0)
- Coordinate loss of a microRNAand protein-coding gene cooperate in the pathogenesis of 5qsyndrome (2016) (0)
- High-Throughput RNA Interference Screening Identifies Synthetic Lethality Between Oncogenic KRAS Dependency and Suppression of STK33 (2008) (0)
- Dooley 1 Nuclear Factor I / B is an Oncogene in Small Cell Lung Cancer (2011) (0)
- Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer (2022) (0)
- Abstract #2344: Selective killing of K-ras mutant cancer cells by novel, small molecule inducers of oxidative stress (2009) (0)
- KRAS AND AGO2 INTERACTION PROMOTE INITIATION OF PLASMABLASTIC LYMPHOMA USING AN IN VIVO MOUSE TRANSPLANT MODEL (2017) (0)
- Protein Truncated Species of Retinoblastoma Tumor Suppression by a Severely (2002) (0)
- Abstract 3447: T cell antigen expression levels govern progression and therapy response in a novel model of colon cancer (2020) (0)
- Abstract 2924: In vivo CRISPR/Cas9 models of microsatellite instable colon cancer reveal recurrent mutations in putative tumor supressor genes (2021) (0)
- NINJA: an inducible genetic model for creating neoantigens in vivo (2020) (0)
- Abstract #5608: Synthetic lethal interaction between oncogenic KRAS dependency and suppression of STK33 in human cancer cells (2009) (0)
- Abstract PR11: Tissue-of-origin dictates the metabolic fate of branched chain amino acids in mutant Kras-driven cancers (2016) (0)
- Abstract 1084: Comprehensive genomic analysis of murine small cell lung carcinoma uncovers recurrent Pten alterations that drive tumor progression and alter tumor genome evolution. (2013) (0)
- Abstract 122: Highly multiplexed, spatially-resolved tissue imaging of genetically engineered mouse models of cancer to discover and characterize immune regulators of tumorigenesis (2021) (0)
- Modeling Human Lung Cancer in Mice: 4th International Mouse Lung Tumorigenesis Symposium (2004) (0)
- Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma (2018) (0)
- Anemia and Ineffective Erythropoiesis Caused by Somatic RAS Mutation. (2004) (0)
- Impaired SHP 2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Factor Receptor-Citation (2010) (0)
- Abstract A43: Loss of Keap1 promotes KRAS-driven lung cancer and results in genotype-specific vulnerabilities (2018) (0)
- Abstract A35: Microenvironmental adaptations drive obesity-associated pancreatic cancer (2019) (0)
- A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
- Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. (2017) (0)
- PD-018a Modulation of tumorigenesis and tumor progression in a K-ras mutated mouse model of lung cancer in the presence of TGF-01 heterozygosity (2005) (0)
- Low neoantigen expression and poor T cell priming underlie early immune escape in cancer (2020) (0)
- Engineering the Cancer Genome (2015) (0)
- Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity (2021) (0)
- Abstract 4447: Deep neural network for automatic histopathologic analysis of murine lung tumors (2019) (0)
- Abstract B148: The miRNA-200 family regulates cell migration and metastasis in lung adenocarcinoma. (2011) (0)
- Abstract P010: Antigen dominance hierarchies shape CD8 T cell phenotypes and immunotherapy response in tumors (2022) (0)
- The Use of NF1 and NF2 Mutant Mouse Strains in the Investigation of Gene Function and Disease Development (1998) (0)
- Abstract 1431: In vivo CRISPR/Cas9 screen of adoptively transferred T cells reveals novel mediators of T cell exhaustion and immunosuppression (2019) (0)
- Abstract A05: Investigating mechanisms of obesity-mediated pancreatic cancer progression (2018) (0)
- Abstract 2506:Smarca4inactivation promotes lineage-specific transformation and early metastatic features in the lung (2021) (0)
- Regulation of Mammary Stem Cell Differentiation by BCL11B (2017) (0)
- target as a functional transcriptional LMO 3 lung adenocarcinoma identifies in NKX 2-1 Integrated cistromic and expression analysis of amplified Material Supplemental (2013) (0)
- Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) (0)
- functions as a haploinsufficient tumor suppressor Dicer 1 Material Supplemental (2009) (0)
- New Limitation Change to Approved for Public Release, Distribution Unlimited from Title: the Use of Nfl and Nf2 Mutant Mouse Strains in the Investigation of Gene Function and Disease Development (0)
- Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5 q-syndrome RUNNING TITLE : COOPERATIVE LOSS OF MIR-145 AND RPS 14 IN 5 Q-MDS (2011) (0)
- Construction of an NF2 Mutant Mouse: Towards an Animal Model of Neurofibromatosis Type 2. (1996) (0)
- Abstract PR2: Functional characterization of p53-regulated long intervening non-coding RNAs (lincRNAs (2012) (0)
- Abstract 1612: Investigating NF-κB pathway as a novel therapeutic target in preclinical lung cancer mouse models (2011) (0)
- Abstract 659: Novel refinements for the autochthonous mouse model of cancer (2016) (0)
- Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma (2022) (0)
- Single-nucleus RNA-seq of frozen archival primary pancreatic ductal adenocarcinoma uncovers multi-compartment intratumoral heterogeneity associated with neoadjuvant treatment. (2020) (0)
- Progressive Genomic Instability in the FVB/Kras[superscript LA2] Mouse Model of Lung Cancer (2011) (0)
- A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
- Central Nervous System Cycle Defects without Apoptosis in the Causes Cell Rb Conditional Mutation of (2003) (0)
- Abstract P023: Mismatch repair deficiency is not sufficient to increase tumor immunogenicity (2022) (0)
- Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr 5 and Lgr 6 Graphical Abstract Highlights (2017) (0)
- 7.013 Introductory Biology, Spring 2005 (2005) (0)
- Abstract 2513: Distinct cancer-intrinsic mechanisms mediate nerve recruitment/outgrowth versus perineural invasion (2023) (0)
- Abstract 2961: The level of mitochondrial apoptotic priming determines cell fate upon p53 restoration (2014) (0)
- Abstract PO-063: Functional interrogation of immune escape in neoantigen-expressing pancreatic cancer identifies a critical role for the CD155/TIGIT axis (2021) (0)
- tumor progression in a mouse model of lung cancer Chronic cisplatin treatment promotes enhanced damage repair and Material (2010) (0)
- AKT Activation and Sensitivity to Dietary Restriction-Null Tumors Cohabiting the Same Lung Display Differential Pten (2013) (0)
- Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML). (2007) (0)
- Survival of pancreatic cancer cells lacking KRAS function (2017) (0)
- Abstract PR11: Antigen dominance hierarchies shape tumor T-cell phenotypes and immunotherapy responses (2020) (0)
- New drug combo shows early potential for treating pancreatic cancer (2021) (0)
- Abstract C22: Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma (2013) (0)
- Brief report Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways (2007) (0)
- The Role of K-ras Signaling in Erythropoiesis In Vivo. (2005) (0)
- Using stem cell biology to design precision medicine for non-small cell lung cancer (2016) (0)
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