Ulf Rüdiger Rapp

Q: What Schools Are Affiliated With Ulf Rüdiger Rapp

Ulf Rüdiger Rapp is affiliated with the following schools: University of Göttingen, University of California, San Diego, University of Würzburg, Massachusetts General Hospital, Harvard University

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Ulf Rüdiger Rapp

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#7136

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#10005

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Biochemistry

#965

World Rank

#1076

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Biology

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Ulf Rüdiger Rapp's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Raf-1 activates MAP kinase-kinase (1992) (1210)
Protein kinase Cα activates RAF-1 by direct phosphorylation (1993) (1195)
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 (1993) (823)
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria (1996) (814)
Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1. (1994) (539)
The ins and outs of Raf kinases. (1994) (535)
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade (2001) (503)
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells (1991) (446)
Ras oncogenes and their downstream targets. (2007) (441)
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. (1983) (430)
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. (1992) (424)
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. (1996) (376)
Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor (1989) (376)
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. (1988) (370)
Protein kinase C alpha activates RAF-1 by direct phosphorylation. (1993) (369)
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 (1992) (344)
Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration (2005) (334)
Identification of the major phosphorylation sites of the Raf-1 kinase. (1993) (326)
Endothelial apoptosis in Braf-deficient mice (1997) (317)
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase (1997) (311)
Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis (2004) (288)
Active Ras induces heterodimerization of cRaf and BRaf. (2001) (286)
Cell cycle targets of Ras/Raf signalling (1998) (274)
Isotype-specific functions of Raf kinases. (1999) (266)
Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. (1994) (255)
UV‐induced activation of AP‐1 involves obligatory extranuclear steps including Raf‐1 kinase. (1993) (254)
Mutational activation of c-raf-1 and definition of the minimal transforming sequence (1990) (247)
Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. (1994) (237)
The Stress Inducer Arsenite Activates Mitogen-activated Protein Kinases Extracellular Signal-regulated Kinases 1 and 2 via a MAPK Kinase 6/p38-dependent Pathway* (1998) (230)
Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus (1985) (224)
Expression of raf family proto-oncogenes in normal mouse tissues. (1990) (217)
Serine- and threonine-specific protein kinase activities of purified gag–mil and gag–raf proteins (1984) (203)
3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways (1996) (190)
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. (1986) (189)
Deamidation of Cdc42 and Rac by Escherichia coliCytotoxic Necrotizing Factor 1: Activation of c-Jun N-Terminal Kinase in HeLa Cells (1999) (186)
Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1 (1997) (185)
Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. (2000) (180)
Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. (2001) (178)
Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals (2001) (175)
MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1* (2005) (173)
Structure and biological activity of human homologs of the raf/mil oncogene (1985) (169)
Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. (1991) (162)
The MKK6/p38 Stress Kinase Cascade Is Critical for Tumor Necrosis Factor-–Induced Expression of Monocyte-Chemoattractant Protein-1 in Endothelial Cells (1999) (158)
The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. (1984) (155)
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl- 2 suppressible mechanism (1995) (155)
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes (1985) (151)
Influenza Virus-induced NF-κB-dependent Gene Expression Is Mediated by Overexpression of Viral Proteins and Involves Oxidative Radicals and Activation of IκB Kinase* (2000) (151)
Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf. (1990) (146)
Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells (1995) (143)
TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins. (2007) (140)
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction (1993) (139)
Regulation of c-myc expression by Ras/Raf signalling (1998) (137)
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. (1991) (136)
Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl (1989) (134)
Craf-1 protein kinase is essential for mouse development (1998) (130)
Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. (1991) (129)
CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation. (1999) (129)
The role of Raf-1 phosphorylation in signal transduction. (1992) (125)
Myc Is a Metastasis Gene for Non-Small-Cell Lung Cancer (2009) (125)
Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. (1994) (124)
T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. (1990) (122)
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. (1987) (122)
Influenza Virus-induced AP-1-dependent Gene Expression Requires Activation of the JNK Signaling Pathway* (2001) (122)
Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis (2000) (119)
Different Mitogen-activated Protein Kinase Signaling Pathways Cooperate to Regulate Tumor Necrosis Factor α Gene Expression in T Lymphocytes* (1999) (118)
Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. (1990) (117)
Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. (1992) (115)
v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. (1994) (115)
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility (2008) (114)
Raf kinases: Oncogenesis and drug discovery (2006) (113)
The Mitogen-activated Protein (MAP) Kinase p38 and Its Upstream Activator MAP Kinase Kinase 6 Are Involved in the Activation of Signal Transducer and Activator of Transcription by Hyperosmolarity* (1999) (113)
Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus (1985) (111)
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. (1994) (111)
Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611 (1984) (110)
Ras-independent Activation of the Raf/MEK/ERK Pathway upon Calcium-induced Differentiation of Keratinocytes* (2000) (109)
The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization (2000) (108)
Colony stimulating factor‐1 (CSF‐1) stimulates temperature dependent phosphorylation and activation of the RAF‐1 proto‐oncogene product. (1990) (108)
raf family serine/threonine protein kinases in mitogen signal transduction. (1988) (108)
Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons (2001) (107)
Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. (1999) (105)
Identification of the 14.3.3 ζ Domains Important for Self-association and Raf Binding (*) (1995) (105)
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. (1990) (104)
Characterization of murine A-raf, a new oncogene related to the v-raf oncogene (1986) (103)
Primary structure of v-raf: relatedness to the src family of oncogenes. (1984) (102)
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. (2004) (101)
Oncogene-induced plasticity and cancer stem cells (2008) (100)
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling (2010) (99)
Associations of B- and C-Raf with Cholesterol, Phosphatidylserine, and Lipid Second Messengers (2002) (99)
Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor. (1991) (99)
Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. (1993) (98)
Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter (1996) (98)
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. (2000) (97)
Expression of the c-raf protooncogene, gamma-glutamyltranspeptidase, and gap junction protein in rat liver neoplasms. (1988) (96)
The regulatory subunit of protein kinase CK2 is a specific A‐Raf activator (1997) (95)
Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf (1984) (95)
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. (1993) (95)
Expression of raf oncogenes activates the PEA1 transcription factor motif (1989) (94)
Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. (1994) (93)
Neurotrophin Receptor-interacting Mage Homologue Is an Inducible Inhibitor of Apoptosis Protein-interacting Protein That Augments Cell Death* (2001) (92)
The Spir actin organizers are involved in vesicle transport processes (2001) (91)
95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site (1992) (84)
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. (2007) (84)
Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2‐positive cancer cells and cancer stem cells (2012) (83)
Enzymatic characteristics of the c-Raf-1 protein kinase. (1994) (83)
An established rat cell line expressing chondrocyte properties. (1988) (82)
High-intensity Raf signals convert mitotic cell cycling into cellular growth. (1998) (79)
Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma. (2008) (79)
Endogenous oncornaviruses in chemically induced transformation. I. Transformation independent of virus production. (1975) (78)
Serine/Threonine Kinases 3pK and MAPK-activated Protein Kinase 2 Interact with the Basic Helix-Loop-Helix Transcription Factor E47 and Repress Its Transcriptional Activity* (2000) (77)
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. (1991) (76)
Regulation of RAF Activity by 14-3-3 Proteins (2009) (76)
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes (2000) (75)
The Raf-1 serine/threonine protein kinase. (1994) (73)
B- and C-RAF Display Essential Differences in Their Binding to Ras (2007) (72)
The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion. (1999) (71)
Activity of Rap1 Is Regulated by Bombesin, Cell Adhesion, and Cell Density in NIH3T3 Fibroblasts* (1998) (71)
Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade (1995) (70)
Insulin activates the Raf-1 protein kinase. (1990) (69)
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells. (1999) (68)
Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells. (1987) (67)
The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. (2000) (67)
Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells. (1994) (67)
Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages (1990) (66)
Reversible Membrane Interaction of BAD Requires two C-terminal Lipid Binding Domains in Conjunction with 14-3-3 Protein Binding* (2006) (66)
Negative regulation of mitochondrial VDAC channels by C-Raf kinase (2002) (66)
Raf and the road to cell survival: a tale of bad spells, ring bearers and detours. (2003) (66)
Immunogenicity of Constitutively Active V599EBRaf (2004) (65)
Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B (2008) (64)
Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human Immunodeficiency Virus Type 1 Replication in T Lymphocytes (1998) (63)
Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. (2007) (63)
Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus (1978) (62)
Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation. (1991) (62)
Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk (2017) (61)
GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction (1997) (61)
Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells. (1999) (61)
The phosphorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor. (1991) (60)
New mammalian transforming retrovirus: demonstration of a polyprotein gene product (1983) (60)
Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression (2010) (59)
C-Raf antagonizes apoptosis induced by IFN-α in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A (2007) (59)
The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells (*) (1995) (59)
Detection of the myristylated gag-raf transforming protein with raf-specific antipeptide sera. (1985) (59)
Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation (2004) (59)
Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria (2001) (59)
Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis. (1987) (58)
Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site (2015) (57)
An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter. (1991) (57)
Negative regulation of c-myc transcription involves myc family proteins. (1988) (56)
Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant. (1994) (55)
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. (2001) (54)
Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells (1995) (54)
Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. (1993) (54)
BuCy RAFs drive cells into MEK addiction. (2006) (53)
Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells* (1999) (53)
Identification of Novel in Vivo Phosphorylation Sites of the Human Proapoptotic Protein BAD (2009) (53)
Activation of NF-κB by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade (1998) (52)
The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation (1998) (52)
B-raf and a B-raf pseudogene are located on 7q in man. (1992) (52)
Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure (2004) (51)
Effects of anti-proliferative cyclic AMP on interleukin 2-stimulated gene expression. (1987) (51)
Regulation of glycolysis by Raf protein serine/threonine kinases. (2002) (51)
Shigella Mediated Depletion of Macrophages in a Murine Breast Cancer Model Is Associated with Tumor Regression (2010) (50)
c-Raf Regulates Cell Survival and Retinal Ganglion Cell Morphogenesis during Neurogenesis (2000) (50)
v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation. (1993) (49)
Constitutive JNK Activation in NIH 3T3 Fibroblasts Induces a Partially Transformed Phenotype* (2002) (49)
Integration of transfected LTR sequences into the c‐raf proto‐oncogene: activation by promoter insertion. (1985) (48)
Generation of oncogenic mouse type C viruses: in vitro selection of carcinoma-inducing variants. (1980) (48)
Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells (1999) (48)
B‐Raf/Rap1 signaling, but not c‐Raf‐1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection (2002) (45)
T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors. (1995) (45)
The Ras-Raf relationship: an unfinished puzzle. (2001) (44)
Generation of oncogenic type C viruses: rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro. (1978) (44)
Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling (2002) (42)
Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice (2004) (42)
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice (2005) (41)
RAF expression in human astrocytic tumors. (2009) (41)
Loss of heterozygosity at the c-raf locus in small cell lung carcinoma. (1989) (40)
Flat reversion by okadaic acid of raf and ret-II transformants. (1989) (40)
A new oncogene, c-raf, is located on mouse chromosome 6 (1984) (40)
RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation during Early Inner Ear Development (2010) (40)
Rapid activation of C-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells. (1993) (39)
Generation of new mouse sarcoma viruses in cell culture. (1978) (39)
Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. (1991) (39)
H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts. (1993) (38)
Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques (1976) (38)
Novel C‐Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation (2005) (37)
Activation of the Xenopus oocyte mitogen-activated protein kinase pathway by Mos is independent of Raf. (1996) (37)
Evidence that Ha-Ras mediates two distinguishable intracellular signals activated by v-Src. (1992) (37)
Induction of transformation and DNA synthesis after microinjection of raf proteins (1990) (35)
The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells. (1991) (35)
Role of raf oncogenes in lung carcinogenesis (1988) (35)
Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line. (1993) (34)
Ras signaling: PP2A puts Ksr and Raf in the right place (2003) (34)
Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells (1987) (33)
Polycomb Group Protein Bmi1 Is Required for Growth of RAF Driven Non-Small-Cell Lung Cancer (2009) (33)
The role of Raf kinases in development and growth of tumors. (1997) (33)
Unique N-region Determines Low Basal Activity and Limited Inducibility of A-RAF Kinase (2007) (32)
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity (2010) (32)
KSR--A Regulator and Scaffold Protein of the MAPK Pathway (2002) (31)
Positive Regulation of A-RAF by Phosphorylation of Isoform-specific Hinge Segment and Identification of Novel Phosphorylation Sites* (2008) (31)
Role of c-myc and other genes in interleukin 2 regulated CT6 T lymphocytes and their malignant variants. (1987) (31)
Validation of a liquid chromatography assay for the quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse serum. (2004) (31)
Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase. (2011) (31)
BAG-1 haplo-insufficiency impairs lung tumorigenesis (2004) (31)
Oncogene activation of HIV-LTR-driven expression via the NF-ϰB binding sites (1993) (30)
Induction of PPARβ and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARβ (2006) (30)
Vivotif® – A ‘Magic Shield’ for Protection against Typhoid Fever and Delivery of Heterologous Antigens (2007) (29)
raf oncogenes in carcinogenesis. (1990) (29)
Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration* (2012) (29)
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. (2001) (29)
Single Substitution within the RKTR Motif Impairs Kinase Activity but Promotes Dimerization of RAF Kinase* (2011) (28)
Transformation by raf and myc oncogenes. (1986) (28)
Isoform-specific Interaction of C-RAF with Mitochondria* (2008) (28)
Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells (2012) (28)
Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice. (1986) (28)
Tet-system for the regulation of gene expression during embryonic development (2001) (27)
Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear (1999) (27)
C-raf-1 proto-oncogene expression relates to radiosensitivity rather than radioresistance. (1994) (27)
Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways. (2002) (27)
Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. (2003) (26)
Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases. (2004) (26)
An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis. (1989) (26)
Selective expression of calcium-binding proteins S100a8 and S100a9 at distinct sites of hair follicles. (2001) (25)
Probing structure and function of the raf protein kinase domain with monoclonal antibodies. (1990) (25)
Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf. (2002) (25)
Mitogen-activated 3p kinase is active in the nucleus. (2004) (24)
Non‐invasive lung cancer diagnosis by detection of GATA6 and NKX2‐1 isoforms in exhaled breath condensate (2016) (24)
Interaction between the Protein Kinase B-Raf and the α-Subunit of the 11S Proteasome Regulator (1998) (24)
Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene (2007) (24)
Molecular organization of the human Raf-1 promoter region (1990) (23)
v-Raf/v-Myc synergism in abrogation of IL-3 dependence: v-Raf suppresses apoptosis. (1992) (23)
B-Raf specific antibody responses in melanoma patients (2004) (23)
Immunohistochemical localization of raf protein kinase in dendritic spines and spine apparatuses of the rat cerebral cortex (1991) (23)
Transient increase of raf protein kinase-like immunoreactivity in the rat dentate gyrus during long-term potentiation (1990) (23)
Transformed 3T3 cells have reduced levels and altered subcellular distribution of the major PKC substrate protein MARCKS. (1991) (23)
Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes. (1991) (23)
Cortical Migration Defects in Mice Expressing A-RAF from the B-RAF Locus (2006) (22)
Cell surface receptors for ecotropic MULV: Detection and tissue distribution of free receptors in vivo (1978) (22)
Establishment and characterization of the epithelial mouse embryo cell line MMC-E. (1979) (22)
In Vitro and In Vivo Antitumor Activity of a Novel Semisynthetic Derivative of Cucurbitacin B (2015) (22)
A-RAF Kinase Functions in ARF6 Regulated Endocytic Membrane Traffic (2009) (21)
Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction. (1980) (21)
Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages (2018) (21)
Identification and characterization of c-raf phosphoproteins in transformed murine cells. (1988) (21)
E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice. (2012) (21)
Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum. (1993) (20)
Acquisition of oncogenicity by endogenous mouse type C viruses: effects of variations in env and gag genes (1978) (20)
A dominant negative Raf-1 mutant prevents v-Src-induced transformation. (1993) (20)
Ablation of BRaf Impairs Neuronal Differentiation in the Postnatal Hippocampus and Cerebellum (2013) (20)
v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice. (1990) (20)
Regulation of A-raf expression. (1996) (20)
The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro‐apoptotic activity of interferon‐α through the inhibition of multiple survival pathways (2007) (19)
BAD association with membranes is regulated by Raf kinases and association with 14-3-3 proteins. (2007) (19)
Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression. (2011) (18)
MK3 controls Polycomb target gene expression via negative feedback on ERK (2012) (18)
Prostaglandin E suppression of platelet-derived-growth-factor-induced Ito cell mitogenesis occurs independent of raf perinuclear translocation and nuclear proto-oncogene expression. (1994) (18)
Genes and gene products involved in growth regulation of tumor cells. (1985) (18)
Raf kinases in lung tumor development. (2003) (18)
Evidence for one or more Raf-1 kinase kinase(s) activated by insulin and polypeptide growth factors. (1991) (18)
The induction of Egr-1 expression by v-Fps is via a protein kinase C-independent intracellular signal that is sequentially dependent upon HaRas and Raf-1. (1992) (18)
Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain. (2004) (18)
Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling (1999) (17)
C-Raf deficiency leads to hearing loss and increased noise susceptibility (2015) (17)
The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (1994) (17)
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells. (1991) (17)
Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli. (1988) (17)
BAD Contributes to RAF-mediated Proliferation and Cooperates with B-RAF-V600E in Cancer Signaling* (2011) (16)
raf/myc-infected erythroid cells are restricted in their ability to terminally differentiate (1989) (16)
Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. (2007) (16)
Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling. (2008) (16)
MYC-Induced Epigenetic Activation of GATA4 in Lung Adenocarcinoma (2012) (15)
A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture (1988) (15)
Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src. (1985) (15)
Role of raf-1 protein kinase in IL-3 and GM-CSF-mediated signal transduction. (1990) (14)
Genes controlling receptors for ecotropic and xenotropic type C virus in Mus cervicolor and Mus musculus (1979) (14)
The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF* (2012) (14)
Induction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta. (2006) (14)
Growth factor regulation of cell cycle progression and cell fate determination. (1995) (13)
Cerebral ischemia induces transient intracellular redistribution and intranuclear translocation of the raf proto-oncogene product in hippocampal pyramidal cells (2004) (13)
Cascading towards vascular disorder gene therapy (1995) (13)
Normal mouse serum contains peptides which induce fibroblasts to grow in soft agar (1983) (13)
Envelope gene sequence of two in vitro-generated mink cell focus-forming murine leukemia viruses which contain the entire gp70 sequence of the endogenous nonecotropic parent (1984) (13)
Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells (2012) (13)
Association of Raf with the CD3 delta and gamma chains of the T cell receptor-CD3 complex. (1994) (12)
Tumor induction by activated JNK occurs through deregulation of cellular growth. (2004) (12)
The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells (2000) (12)
3'-Terminal region of avian carcinoma virus MH2 shares sequence elements with avian sarcoma viruses Y73 and SR-A (1984) (12)
Polycomb group protein Bmi1 negatively regulates IL‐10 expression in activated macrophages (2011) (12)
The raf Oncogene (1985) (12)
Dome formation by a retrovirus-induced lung adenocarcinoma cell line. (1982) (11)
Susceptibility and resistance to J3V1 retrovirus-induced murine plasmacytomagenesis in reconstituted severe combined immunodeficient mice. (1993) (11)
A-raf oncogene localizes on mouse X chromosome to region some 10–17 centimorgans proximal to hypoxanthine phosphoribosyltransferase gene (1987) (11)
Specific antibody-receptor interactions trigger InlAB-independent uptake of listeria monocytogenes into tumor cell lines (2011) (11)
Histogenesis and clonality of pancreatic tumors induced by v-myc and v-raf oncogenes in NFS/N mice. (1988) (11)
B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade (2005) (10)
Genetic transmission of retroviral genes and cellular oncogenes (1980) (10)
Generation dependent reduction of tTA expression in double transgenic NZL‐2/tTACMV mice (2001) (10)
Oncogenes: clinical relevance. (1987) (10)
The effect of c-raf antisense oligonucleotides on growth factor-induced proliferation of hematopoietic cells. (1996) (10)
Epidermal growth factor-induced alterations in proliferating mouse epithelial cells. (1980) (10)
Structure and Biological Activity of Human Homologs of the rafimil Oncogene (9)
Apoptosis regulation by Raf, Bcl-2, and R-Ras. (1997) (9)
Phorbol ester stimulates the synthesis of sphingomyelin in NIH 3T3 cells A diminished response in cells transformed with human A‐raf carrying retrovirus (1988) (9)
In vitro transformation of murine bone marrow cells with a v-raf/v-myc retrovirus yields clonally related mature B cells and macrophages. (1988) (9)
Immunohistochemical detection of raf protein kinase in cerebral cortical areas of adult guinea pigs and rats (1993) (9)
Murine leukemia virus-mediated transformation of a mouse epithelial cell line MMC-E. (1982) (8)
Apoptosis in tumor cells (1997) (8)
Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli. (2009) (8)
Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth* (2014) (8)
Abrogation of IL-3 dependence of myeloid FDC-P1 cells by tyrosine kinase oncogenes is associated with induction of c-myc. (1988) (7)
Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling. (1999) (7)
protein kinase by cyclic AMP in PC 12 cells . Ras-dependent activation of mitogen-activated Differential regulation of Raf-1 and B-Raf and (1995) (7)
Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sites. (1993) (7)
Raf protein serine/threonine kinases (2007) (7)
Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer (2017) (7)
Genome structure of mink cell focus-forming murine leukemia virus in epithelial mink lung cells transformed vitro by iododeoxyuridine-induced C3H/MuLV cells (1983) (6)
Mutational Activation ofc-raf-1 andDefinition oftheMinimal Transforming Sequence (1990) (6)
Protooncogene-encoded protein kinases in interleukin-2 signal transduction. (1993) (6)
Plasmacytoma induction by J series of v-myc recombinant retroviruses: evidence for the requirement of two (raf and myc) oncogenes for transformation. (1988) (6)
The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro-apoptotic activity of interferon-α through the inhibition of multiple survival pathways (International Journal of Cancer (2007) 121, (2317-2330)) (2008) (6)
Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. (2011) (6)
Raf-dependent signaling pathways in cell growth and differentiation (1998) (6)
Kinetics of expression of infectious ecotropic, xenotropic, and mink cell focus-forming murine leukemia virus after 5-iododeoxyuridine induction of cells from high- and low-leukemia mouse strains (1983) (6)
Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator. (1998) (6)
Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control. (2002) (5)
Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation (2020) (5)
Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers (2021) (4)
Metastasis as a faulty recapitulation of ontogeny (2007) (4)
Sarcoma virus-specific phosphoproteins are packaged in "rescued" type C virions. (1979) (4)
Can BAD pores be good? New insights from examining BAD as a target of RAF kinases. (2010) (4)
Transformation of cultured epithelial cells by ethylnitrosourea. Altered expression of type I procollagen chains. (1984) (4)
Production and characterization of monoclonal antibodies against human BAD protein. (1998) (4)
Rapid induction of plasmacytomas in mice by pristane and a murine recombinant retrovirus containing an avian v-myc and a defective raf oncogene. (1986) (4)
Tyr728 in the Kinase Domain of the Murine Kinase Suppressor of RAS 1 Regulates Binding and Activation of the Mitogen-activated Protein Kinase Kinase* (2013) (4)
Replication-defective S+L-Moloney MSV codes for an envelope glycoprotein with moloney MuLV- and MCF-MuLV-specific determinants. (1979) (4)
Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF (2018) (3)
Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci (1989) (3)
Deregulation of the c-myc and N-myc genes in transformed cells. (1988) (3)
Neuronal expression of the RAF protooncogene in the spinal cord of adult guinea pigs. (1993) (3)
Expression of B-RAF V600E in Type II Pneumocytes Causes Abnormalities in Alveolar Formation, Airspace Enlargement and Tumor Formation in Mice (2011) (3)
A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas. (1990) (3)
Expression of the raf protooncogene in glial cells of the adult rat cerebral cortex, brain stem and spinal cord. (1994) (3)
Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma (2005) (3)
Tumors of newborn NFS/N mice infected with murine retroviruses containing avian v-myc. (1986) (3)
Expression of human c-raf-1 oncogene proteins in E. coli. (1988) (2)
Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures. (1986) (2)
Characterization of a murine monoclonal antibody that detects a C-terminal fragment of the raf oncogene product. (1988) (2)
Survival Regulation by Ras and Raf (2008) (2)
Epidermal GrowthFactor (EGF)Stimulates Association andKinase Activity ofRaf-1 withtheEGF Receptor (1991) (1)
Raf Function Is Required for Proliferation of NIH|3T3 Cells and Transformation by Nonnuclear Oncogenes (1992) (1)
Prohibitin is required for Ras-Raf-MAPK signaling and epithelial cell migration (2005) (1)
Regulation and function of Raf-kinases (2003) (1)
Chromatin , Gene , and RNA Regulation MYC-Induced Epigenetic Activation of GATA 4 in Lung Adenocarcinoma (2013) (1)
MMC-E cells--origin and changes in karyotype accompanying malignant transformation. (1985) (1)
Expression of the c-mf Protooncogene, 7-Glutamyltranspeptidase, and Gap Junction Protein in Rat Liver Neoplasms1 (2006) (1)
Mechanisms in interleukin 3 regulated growth and differentiation. (1987) (1)
Expression of raf-protooncogenes in the hippocampus and hippocampal slices of the guinea-pig. (1992) (1)
C-Raf deficiency leads to hearing loss and increased noise susceptibility (2015) (1)
Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate (2017) (1)
Differential gene expression in apoptotic 32Dcl3 cells: induction of metallothionein (2004) (1)
Genetic markers for oncogenes, growth factors, and cystic fibrosis. (1989) (1)
German Cancer Society: 13th International AEK/AIO Congress of the German Cancer Society, Wrzburg, March 2005: Abstracts (2005) (1)
Induction of raf-1 protein immunoreactivity in guinea pig hippocampal slices during the in vitro maintenance (2004) (1)
Raf kinases and cancer (2004) (0)
446: A gain of function by the cancer-associated FGFR4 c.1162G>A (p.Gly388Arg) variant (2014) (0)
Characterization ofMurineA-raf, aNewOncogene Related to thev-raf Oncogene (1986) (0)
Increased frequency of IFN-γ-secreting CD8T cells after p (2011) (0)
3-Kinase-Dependent Signals Requires MEK-and Phosphatidylinositol Apoptosis Suppression by Raf-1 and MEK 1 (2001) (0)
The Regulation of Genes Encoding Extracellular Matrix Proteins: In Vitro Studies and Relationships to Teratogenic Mechanisms (2019) (0)
Establishment and Characterization of the Epithelial Mouse Embryo Cell Line MMC-E 1 (2006) (0)
Raf1: Raf1 protein kinase (vertebrates) (1995) (0)
In vitro proliferation of human large granular lymphocytes withv-raf/v-myc recombinant retrovirus (1988) (0)
Influenza virus replication and nuclear-cytoplasmic transport of the viral RNP complexes is impaired upon specific inhibition of the RAF/MEK/ERK signalling cascade (2000) (0)
A-Raf: A-Raf protein kinase (vertebrates) (1995) (0)
Thmsformation and Insertional Mutagenesis In Vitro of Primary Hematopoietic Stem CeO Cultures (0)
Correction: Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation. (2022) (0)
The Role of Protein-Protein Interactions in the Activation Cycle of RAF Kinases (2010) (0)
Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor (1991) (0)
MK3 controls Polycomb target gene expression via negative feedback on ERK (2012) (0)
The Tumor Suppressor DiRas 3 Forms a Complex with HRas and C-RAF and Regulates Localization , Dimerization and Kinase Activity of C-RAF * (2012) (0)
New pyridopyrazines and their use as kinasemodulatorer (2004) (0)
Using raf to inhibit bacterial porin factors (2001) (0)
C-RAF deficiency causes cochlear abnormalities and profound sensorineural deafness in the mice (2012) (0)
Identification of the Raf-HlyAs fusion protein by immunoblotting (2011) (0)
Abstract 3227: Lung-targeted expression of B-RAF V600E in alveolar type II cells causes emphysema and delayed adenoma in mice (2010) (0)
The role of NFκB/IKK2 pathway in the pathogenesis of lung cancer (2012) (0)
[Deregulation of intracellular signal pathways in colorectal carcinoma]. (2000) (0)
Expression of the cmf Protooncogene , 7-Glutamyltranspeptidase , and Gap Junction Protein in Rat Liver Neoplasms 1 (2006) (0)
Role of the Raf Signal Transduction Pathway in Fos/Jun Regulation and Determination of Cell Fates (2017) (0)
Scheme for preparation of a novel semisynthetic derivative of cucurbitacin B (DACE). (2015) (0)
Cells as a carrier for bacteria (2004) (0)
PEA1 transcription factor motif. Expression of raf oncogenes activates the (2013) (0)
Mitogen-activated Protein Kinase Kinase Binding and Activation of the Kinase Suppressor of RAS 1 Regulates in the Kinase Domain of the Murine 728 Tyr Signal (2013) (0)
Microorganisms as carriers of coding for antigenic and protein toxins nucleotide sequences, methods for production and uses thereof (2007) (0)
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility (2009) (0)
raflmyc-Infected Erythroid Cells AreRestricted inTheirAbility ToTerminally Differentiate (1989) (0)
Increase of mortality after influenza A virus infection in mice expressing active Raf kinase in the lung (2003) (0)
Nucleic acid encoding at least a part of raf sequence with a MEKK1 binding site (2000) (0)
The Role oj Raj Kinases in Development and Growth oj Tumors (0)
New Pyridopyrazine and their use as kinase inhibitors (2003) (0)
Intracellular bacteria as vaccine carriers — new weapons against cancer? (2001) (0)
Genome structure of MCF/MuLV in epithelial mink lung cells transformed in vitro by IdUrd-induced C3H/MuLV cells. (1983) (0)
EVALUATION OF CYTOTOXIC ACTIVITY OF CUCURBITACINS AND THEIR SEMISYNTHETIC DERIVATIVES (2014) (0)
Abstract 1396: The role of NFκB/IKK2 pathway in the pathogenesis of lung cancer (2012) (0)
Role of raf and myc Oncogenes in Signal Transduction (2020) (0)
Evolution of oncogenic mouse type-C viruses in cell culture. (1980) (0)
serines 63 and 73. stimulates c-Jun activity by phosphorylation of Oncoprotein-mediated signalling cascade (2013) (0)
Activation of a type C virus particle in cells from the inbred mouse strain 129/J: Antigenic relationship with the horizontally transmitted type C viruses of primates (2005) (0)
Abstract 4681: Characterization of pulmonary hypertension in lung cancer. (2013) (0)
Supplementary material to the paper "B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade" (2005) (0)
Test system for the detection of cancer (2002) (0)
Neoplasms-Glutamyltranspeptidase , and Gap Junction Protein in Rat Liver γ Protooncogene , raf Expression of the c-Updated Version (2006) (0)
The method and test system for the detection of nerve cell-protective substances (2001) (0)
cells the monocyte chemoattractant protein-1 gene in primary endothelial dependent transcription of - B κ Multiple signaling pathways regulate NF- (2013) (0)

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