Ulrich K. Laemmli
#7,079
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Swiss biochemist
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Ulrich K. Laemmlibiology Degrees
Biology
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#237
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Biochemistry
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#3
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Biology
Ulrich K. Laemmli's Degrees
- PhD Biochemistry University of Geneva
Why Is Ulrich K. Laemmli Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ulrich K. Laemmli, real name Lämmli, is a Professor in the biochemistry and molecular biology departments at University of Geneva. He is known for the refinement of SDS-PAGE, a widely used method for separating proteins based on their electrophoretic mobility. His paper describing the method is among the most cited scholarly journal articles of all time. His current research involves studying the structural organization of nuclei and chromatin within the cell.
Ulrich K. Laemmli's Published Works
Published Works
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 (1970) (221674)
- Cleavage of structural proteins during (1970) (15743)
- Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. (1977) (4468)
- Maturation of the head of bacteriophage T4. I. DNA packaging events. (1973) (3477)
- Maturation of the head of bacteriophage T4. II. Head-related, aberrant tau-particles. (1973) (1153)
- Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold (1984) (997)
- The structure of histone-depleted metaphase chromosomes (1977) (970)
- Polypeptides of the tail fibres of bacteriophage T4. (1971) (813)
- The detection of DNA-binding proteins by protein blotting (1980) (626)
- Metaphase chromosome structure: Evidence for a radial loop model (1979) (522)
- Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster (1986) (514)
- The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes. (2008) (507)
- Metaphase chromosome structure. Involvement of topoisomerase II. (1986) (489)
- Form-determining function of the genes required for the assembly of the head of bacteriophage T4. (1970) (415)
- A glimpse at chromosomal order (1987) (391)
- Chromatin Boundaries in Budding Yeast The Nuclear Pore Connection (2002) (378)
- Higher order metaphase chromosome structure: Evidence for metalloprotein interactions (1982) (376)
- A factor preventing the major head protein of bacteriophage T4 from random aggregation. (1970) (367)
- Chromosome assembly in vitro: Topoisomerase II is required for condensation (1991) (365)
- Metaphase chromosome structure: Bands arise from a differential folding path of the highly AT-rich scaffold (1994) (364)
- Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. (1992) (336)
- Visualization of chromosomal domains with boundary element-associated factor BEAF-32 (1995) (328)
- A two-step scaffolding model for mitotic chromosome assembly. (2003) (289)
- Preferential, cooperative binding of DNA topoisomerase II to scaffold‐associated regions. (1989) (283)
- Characterization of DNA condensates induced by poly(ethylene oxide) and polylysine. (1975) (283)
- SAR‐dependent mobilization of histone H1 by HMG‐I/Y in vitro: HMG‐I/Y is enriched in H1‐depleted chromatin. (1993) (276)
- Architecture of metaphase chromosomes and chromosome scaffolds (1983) (270)
- Nup-PI: the nucleopore-promoter interaction of genes in yeast. (2006) (270)
- The organisation of chromatin loops: characterization of a scaffold attachment site (1986) (257)
- Role of nonhistone proteins in metaphase chromosome structure (1977) (247)
- The metaphase scaffold is helically folded: Sister chromatids have predominantly opposite helical handedness (1988) (216)
- Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element (1991) (216)
- Non-histone proteins and long-range organization of HeLa interphase DNA. (1982) (211)
- Metaphase chromosome structure: the role of nonhistone proteins. (1978) (199)
- ChIC and ChEC; genomic mapping of chromatin proteins. (2004) (170)
- SARs are cis DNA elements of chromosome dynamics: Synthesis of a SAR repressor protein (1995) (163)
- In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics. (1992) (163)
- Isolation of a protein scaffold from mitotic HeLa cell chromosomes. (1977) (162)
- Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei. (1982) (159)
- Highly preferential nucleation of histone H1 assembly on scaffold-associated regions. (1989) (143)
- Interaction of DNA with nuclear scaffolds in vitro. (1988) (133)
- Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A (1992) (129)
- Scaffold attachment of DNA loops in metaphase chromosomes. (1988) (124)
- The scs' boundary element: characterization of boundary element-associated factors (1997) (118)
- Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA).oligo(dT) tracts. (1989) (116)
- A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin. (1993) (115)
- Facilitation of chromatin dynamics by SARs. (1998) (109)
- Correlation between structural transformation and cleavage of the major head protein of T4 bacteriophage (1976) (100)
- Identification of a Class of Chromatin Boundary Elements (1998) (98)
- SARs stimulate but do not confer position independent gene expression. (1994) (95)
- Evidence for an antagonistic relationship between the boundary element-associated factor BEAF and the transcription factor DREF (1999) (94)
- Bacteriophage T4 tail assembly: structural proteins and their genetic identification. (1973) (91)
- Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster. (2000) (87)
- Metaphase chromosome structure (1977) (87)
- Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides (2001) (80)
- Structural and dynamic functions establish chromatin domains. (2003) (78)
- Maturation of the head of bacteriophage T4. IV. The proteins of the core of the tubular polyheads and in vitro cleavage of the head proteins. (1974) (74)
- Improved methods for the isolation of individual and clustered mitotic chromosomes. (1987) (72)
- A simple method to renature DNA-binding proteins separated by SDS-polyacrylamide gel electrophoresis. (1993) (70)
- Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome. (1986) (68)
- Relation of chromosome structure and gene expression. (1987) (68)
- Chromatin opening of DNA satellites by targeted sequence-specific drugs. (2000) (68)
- Maturation of the head of bacteriophage T4. V. A possible DNA packaging mechanism: in vitro cleavage of the head proteins and the structure of the core of the polyhead. (1974) (64)
- Chromosome structure: improved immunolabeling for electron microscopy (2005) (62)
- Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPα but not importin α (1999) (62)
- From the chromosomal loops and the scaffold to the classic bands of metaphase chromosomes. (1993) (59)
- The AT-Hook Protein D1 Is Essential for Drosophila melanogaster Development and Is Implicated in Position-Effect Variegation (2002) (58)
- Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide (2006) (54)
- Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains (2002) (54)
- Head length determination in bacteriophage T4: the role of the core protein P22. (1976) (48)
- Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins. (1984) (41)
- Morphogenetic core of the bacteriophage T4 head. Structure of the core in polyheads. (1977) (40)
- Maturation of the head of bacteriophage T4. III. DNA packaging into preformed heads. (1974) (40)
- Cell cycle changes in Physarum polycephalum histone H1 phosphate: relationship to deoxyribonucleic acid binding and chromosome condensation. (1980) (38)
- Silver staining the chromosome scaffold (2004) (28)
- Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha. (1999) (27)
- Mapping nucleolar proteins with monoclonal antibodies (1984) (27)
- Levels of organization of the DNA in eucaryotic chromosomes. (1978) (22)
- Maturation of the head of bacteriophage T4: 9-aminoacridine blocks a late step in DNA packaging. (1979) (19)
- Studies on the morphopoiesis of the head of phage T-even (1968) (12)
- A Two-Step Scaffolding Model for Mitotic (2003) (8)
- Studies on the maturation of the head of bacteriophage T4. (1976) (7)
- Packaging genes into chromosomes (1996) (2)
- CHROMOSOME STRUCTURAL STUDIES (1981) (2)
- EVIDENCE FOR A STRUCTURAL ROLE OF COPPER IN HISTONE-DEPLETED CHROMOSOMES AND NUCLEI (1981) (1)
- A nuclear traffic jam: unraveling multicomponent machines and compartments. (1996) (1)
- Isolation ofaprotein scaffold frommitotic HeLacell chromosomes (metaphase/nonhistones/DNA superstructure/micrococcal nuclease/dextran sulfate) (1977) (0)
- The Biochemistry Department of the University of Geneva: Understanding the Molecular Basis and Function of Intracellular Organization. (2009) (0)
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