Ulrich Mahlknecht

Ulrich Mahlknecht's AcademicInfluence.com Rankings

Ulrich Mahlknecht

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#16944

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#11414

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Philosophy

Why Is Ulrich Mahlknecht Influential?

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According to Wikipedia, Ulrich Rudolph Mahlknecht is an internationally renowned German/Italian physician scientist. Scientific achievements Mahlknecht grew up in in South Tyrol, Italy. He studied medicine at the University of Bochum, the University of Birmingham, the Paris-Sud 11 University and the University of Tübingen, where he received his medical doctorate in 1995. He received his postgraduate medical training in internal medicine at the University of Freiburg in Freiburg im Breisgau. From 1996 until 1999 Ulrich Mahlknecht was a graduate student at the Picower Graduate School Of Molecular Medicine , where he was then employed as a postdoc and later as the Senior Scientist. He has actively published in cancer and HIV research, authoring several classic papers. From 1999 until 2003 he received specialist training in internal medicine and hematology/oncology at the Goethe University Frankfurt in Frankfurt am Main, where he became an assistant professor of internal medicine. From 2004 until 2007 he was an associate professor at the University Hospital Heidelberg where he was the head of the acute leukemias and myelodysplastic syndromes task force. Ulrich Mahlknecht was the founder of the Heidelberg excellence center for myelodysplastic syndromes. Since 2012 Ulrich Mahlknecht is head of the department of hematology/oncology at the St. Lukas Klinik in Solingen, Germany.

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Ulrich Mahlknecht's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 (1998) (437)
Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study (2012) (270)
Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease (2000) (185)
Role of histone deacetylase inhibitors in the treatment of cancer (Review). (2004) (122)
SIRTUIN 1: regulating the regulator. (2008) (96)
Azacytidine causes complex DNA methylation responses in myeloid leukemia (2008) (91)
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. (2006) (90)
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. (2009) (80)
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen‐activated protein kinase activities (2007) (78)
Histone Deacetylase 3, a Class I Histone Deacetylase, Suppresses MAPK11-Mediated Activating Transcription Factor-2 Activation and Represses TNF Gene Expression1 (2004) (77)
Stem cells and ageing (2005) (74)
Age-related changes in peripheral blood counts in humans. (2010) (69)
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells (2010) (67)
Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1. (2006) (67)
Resistance to Apoptosis in HIV-Infected CD4+ T Lymphocytes Is Mediated by Macrophages: Role for Nef and Immune Activation in Viral Persistence1 (2000) (65)
Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group (2009) (64)
Valproic Acid Sensitizes Chronic Lymphocytic Leukemia Cells to Apoptosis and Restores the Balance Between Pro- and Antiapoptotic Proteins (2008) (63)
Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene. (2005) (61)
On the epigenetics of vascular regulation and disease (2012) (59)
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene. (2006) (54)
Curcumin Intake Affects miRNA Signature in Murine Melanoma with mmu-miR-205-5p Most Significantly Altered (2013) (53)
Stem cells and ageing. The potential of stem cells to overcome age-related deteriorations of the body in regenerative medicine. (2005) (52)
SNP analyses in cytarabine metabolizing enzymes in AML patients and their impact on treatment response and patient survival: identification of CDA SNP C-451T as an independent prognostic parameter for survival (2009) (51)
GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. (2014) (49)
The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines. (2005) (46)
NF‐κB‐dependent control of HIV‐1 transcription by the second coding exon of Tat in T cells (2008) (45)
Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization (2006) (44)
Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. (2008) (43)
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines. (2012) (42)
Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. (2006) (41)
HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity. (2009) (37)
Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1 (2013) (37)
DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population (2013) (36)
FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). (2005) (36)
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells (2008) (35)
Valproic Acid and All-Trans Retinoic Acid: Meta-Analysis of a Palliative Treatment Regimen in AML and MDS Patients (2008) (33)
Cooking enhances curcumin anti-cancerogenic activity through pyrolytic formation of "deketene curcumin". (2014) (33)
Genomic organization and chromosomal localization of the human histone deacetylase 3 gene. (1999) (31)
Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells? (2001) (31)
Activation of human T cells by the superantigen Staphylococcus enterotoxin B: analysis on a cellular level. (1994) (31)
Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse. (2009) (30)
Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages. (2008) (27)
Cloning and structural characterization of the human histone deacetylase 6 gene. (2003) (22)
ESR1 single nucleotide polymorphisms predict breast cancer susceptibility in the central European Caucasian population. (2013) (22)
Far-Western based protein-protein interaction screening of high-density protein filter arrays. (2001) (21)
Epigenetic regulation of cellular adhesion in cancer. (2011) (21)
Histone Deacetylase 3, a Class I Histone Deacetylase, Suppresses MAPK11-Mediated Activating Transcription Factor-2 Activation and Represses TNF Gene Expression (2004) (20)
The sirtuins in the pathogenesis of cancer (2010) (20)
Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein (2014) (19)
The toxic shock syndrome toxin-1 induces anergy in human T cells in vivo. (1996) (19)
Pharmacogenomics: questions and concerns (2005) (17)
Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines (2011) (16)
Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5). (2000) (15)
UKCCCR guidelines for the use of cell lines in cancer research (1999) (15)
Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). (2003) (14)
Cloning and characterization of the murine histone deacetylase (HDAC3). (1999) (13)
Assignment1 of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization (2001) (13)
Wogonin sensitizes resistant malignant cells to TNFα-and TRAIL-induced apoptosis. Commentary (2006) (13)
SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability. (2010) (12)
The T_T genotype within the NME1 promoter single nucleotide polymorphism −835 C/T is associated with an increased risk of cytarabine induced neurotoxicity in patients with acute myeloid leukemia (2012) (12)
High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region (1999) (11)
Clinical Epigenetics is now a fully open access journal (2011) (11)
Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse. (2009) (11)
Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9). (2002) (11)
Chronic lymphocytic leukaemia and concomitant relapsing polychondritis: a report on one treatment for the combined manifestation of two diseases. (2005) (10)
Successful treatment of disseminated central nervous aspergillosis in a patient with acute myeloblastic leukemia. (1997) (10)
Interim Analysis of a Prospective Randomised Study Comparing a Therapeutic Platelet Transfusion Strategy with the Prophylactic Platelet Transfusion Standard in Patients after Autologous Peripheral Stem Cell Transplantation (ASCT). (2006) (9)
Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells (2010) (9)
GRHL 1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC 3 (2013) (9)
Involvement of sirtuins in life-span and aging related diseases. (2012) (9)
Sequencing of genomic DNA. (1999) (8)
Multidrug-related protein 1 (MRP1) polymorphisms rs129081, rs212090, and rs212091 predict survival in normal karyotype acute myeloid leukemia (2020) (7)
Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course (2016) (7)
First experiences with DIN ISO 14835-1 in the context of vibration-induced white finger disease (2006) (7)
Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse. (2011) (7)
Phase 2 trial of the continuous IV administration of interferon-beta in patients with disseminated malignant melanoma. (2006) (5)
Class I HDAC SNP analysis in healthy donors compared to AML patients (2007) (5)
Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma (2010) (5)
Cloning, chromosomal characterization and FISH mapping of the NAD(+)-dependent histone deacetylase gene sirtuin 5 in the mouse. (2013) (5)
Assignment1 of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization (1999) (4)
Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease (2012) (4)
The irreplaceable image: Black tea delays recovery from iron-deficiency anemia. (2001) (4)
Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3 (2010) (3)
High CR-Rate after Intensive Chemotherapy but Disappointing Results after Palliative Treatment in Patients with Acute Myeloid Leukemia Above the Age of 60 Years: An Analysis of the AML97#38 Study of the East German Hematology and Oncology Study Group (OSHO). (2007) (2)
SIRT 3 SNPs validation in 640 individuals , functional analyses and new insights into SIRT 3 stability (2)
[Epigenetic regulators as novel therapeutic targets in hematology/oncology]. (2003) (2)
On the epigenetics of vascular regulation and disease (2012) (1)
HDAC3, a Class I Histone Deacetylase, Interacts with the P38 Pathway and Suppresses MAPK11-Mediated ATF-2 Activation and TNF Gene Expression. (2004) (1)
[Pharmacogenomics: principles and perspectives]. (2006) (1)
Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1 (2013) (1)
DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population (2013) (1)
Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany (2016) (1)
Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 ( Sirt 3 ) in the mouse (1)
Multidrug-Related Protein 1 (MRP1) Polymorphisms rs129081, rs212090, and rs212091 Predict Survival In Acute Myeloid Leukemia (2013) (1)
Contents Vol. 112, 2006 (2006) (0)
Reviewer acknowledgement 2015 (2015) (0)
Recommendations from the society for diagnosis and therapy of haematological and oncological diseases Myelodysplastic Syndromes (2018) (0)
Reviewer acknowledgement 2013 (2013) (0)
HIV-1 Nef protein inhibits brefeldin A mediated apoptosis in primary human macrophages (2014) (0)
Reviewer Acknowledgement 2014 (2014) (0)
Reviewer acknowledgement 2013 (2013) (0)
Characterization of the NAD-Dependent Human Histone Deacetylases Gene Sirtuin 1 and Its Implications on Aging and the Development of Malignant Disease. (2006) (0)
Reviewer acknowledgement 2016 (2016) (0)
Histone-Modifying Drugs in Aging (2010) (0)
Reviewer acknowledgement 2016 (2016) (0)
Subject Index Vol. 84, 1999 (1999) (0)
Activation in Viral Persistence Macrophages: Role for Nef and Immune T Lymphocytes Is Mediated by +Resistance to Apoptosis in HIV-Infected CD4 (2000) (0)
Chromosomal Instability Correlates with Poor Outcome in Patients with Myelodysplastic Syndromes (2008) (0)
Darwinism and pharmacogenomics: from 'one treatment fits all' to 'selection of the richest'? (2004) (0)
Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis Running title: Wogonin sensitizes TNFα- and TRAIL-induced apoptosis (2006) (0)
Reviewer Acknowledgement 2014 (2014) (0)
apoptosis - and TRAIL-induced α Wogonin sensitizes resistant malignant cells to TNF (2013) (0)
Introductory editorial (2010) (0)
Unrelated Hematopoietic Blood Stem Cell Transplantation in Patients with Acute Myelogenous Leukemia (AML) in First Remission. (2006) (0)
Abstract 1924: The paraproteins of patients with familial MGUS / multiple myeloma (MM) target family-specific antigens: Experience with paratarg-7 and paratarg-8 (2010) (0)
Represses TNF Gene Expression Activating Transcription Factor-2 Activation Deacetylase , Suppresses MAPK 11-Mediated Histone Deacetylase 3 , a Class I Histone and Georges (2004) (0)
Assignment1 of the human histone deacetylase 4 gene (HDAC4) to chromosome 2q37.2 by in situ hybridization (2001) (0)
P01.030 Combination of Tumor Treating Fields (TTFields) and radiochemotherapy in patients with newly diagnosed glioblastoma (2018) (0)
Reviewer acknowledgement 2015 (2015) (0)
Subject Index Vol. 86, 1999 (1999) (0)
Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease (2012) (0)

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