Urs A. Meyer
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Physician-scientist and clinical pharmacologist
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Urs A. Meyermedical Degrees
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Urs A. Meyerphilosophy Degrees
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Urs A. Meyer's Degrees
- Doctorate Medicine University of Zurich
- PhD Pharmacology University of Zurich
Why Is Urs A. Meyer Influential?
(Suggest an Edit or Addition)According to Wikipedia, Urs Albert Meyer is a Swiss physician-scientist and clinical pharmacologist. Life Meyer is professor emeritus of pharmacology at the Biozentrum University of Basel. After clinical and research training at the University of California, San Francisco, USA, he worked as assistant professor in clinical pharmacology at the same institution. In 1974, he became Head of Clinical Pharmacology at the University Hospital of Zurich. From 1983 to 2008, Meyer carried out research and taught as professor of pharmacology at the Biozentrum University of Basel, where he also acted as Chairman. He has served in various World Health Organization and National Institutes of Health functions and was president of the Clinical Section of the Swiss National Science Foundation.
Urs A. Meyer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. (1994) (961)
- Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. (1994) (795)
- The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology (2006) (718)
- Characterization of the common genetic defect in humans deficient in debrisoquine metabolism (1988) (714)
- Advances in Drug Research (1964) (606)
- Pharmacogenetics and adverse drug reactions (2000) (598)
- Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. (1989) (566)
- Cyclosporine metabolism in human liver: Identification of a cytochrome P‐450III gene family as the major cyclosporine‐metabolizing enzyme explains interactions of cyclosporine with other drugs (1988) (564)
- Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems (2014) (484)
- Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification (1990) (465)
- Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. (1989) (461)
- Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia (2005) (448)
- Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice (2008) (436)
- Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. (1990) (432)
- The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. (1989) (428)
- Nomenclature for human CYP2D6 alleles. (1996) (409)
- Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice (2013) (405)
- Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. (1997) (402)
- Pharmacogenetics – five decades of therapeutic lessons from genetic diversity (2004) (399)
- Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies. (1973) (379)
- Nomenclature for N-acetyltransferases. (1995) (378)
- Molecular mechanism of slow acetylation of drugs and carcinogens in humans. (1991) (371)
- Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α (2005) (350)
- Epidemiology-driven neurodevelopmental animal models of schizophrenia (2010) (348)
- Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice (2012) (342)
- In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders (2009) (324)
- Schizophrenia and Autism: Both Shared and Disorder-Specific Pathogenesis Via Perinatal Inflammation? (2011) (321)
- A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. (2009) (317)
- Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. (1991) (290)
- Induction of drug metabolism: the role of nuclear receptors. (2008) (289)
- Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. (1990) (280)
- The Neurodevelopmental Impact of Prenatal Infections at Different Times of Pregnancy: The Earlier the Worse? (2007) (277)
- Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4 (1989) (276)
- High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. (1987) (268)
- Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes. (1991) (262)
- Immunological stress at the maternal–foetal interface: A link between neurodevelopment and adult psychopathology (2006) (259)
- Developmental neuroinflammation and schizophrenia (2013) (258)
- Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (2001) (249)
- Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. (1993) (239)
- Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling (2008) (236)
- Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. (1988) (230)
- Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia (2017) (226)
- Identification and functional characterization of eight CYP3A4 protein variants. (2001) (226)
- Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. (1991) (223)
- Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond. (2011) (223)
- Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. (1990) (222)
- Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia. (2009) (219)
- Late Prenatal Immune Activation in Mice Leads to Behavioral and Neurochemical Abnormalities Relevant to the Negative Symptoms of Schizophrenia (2010) (216)
- Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. (1988) (215)
- To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models (2012) (214)
- Drug metabolism in adult rat hepatocytes in primary monolayer culture. (1977) (211)
- PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE (1973) (209)
- Acute porphyrias: pathogenesis of neurological manifestations. (1998) (207)
- A LONGITUDINAL EXAMINATION OF THE NEURODEVELOPMENTAL IMPACT OF PRENATAL IMMUNE ACTIVATION IN MICE REVEALS PRIMARY DEFECTS IN DOPAMINERGIC DEVELOPMENT RELEVANT TO SCHIZOPHRENIA (2010) (207)
- Relative Prenatal and Postnatal Maternal Contributions to Schizophrenia-Related Neurochemical Dysfunction after In Utero Immune Challenge (2008) (206)
- Overview of enzymes of drug metabolism (1996) (202)
- Intermittent acute porphyria--demonstration of a genetic defect in porphobilinogen metabolism. (1972) (202)
- Induction of Drug Metabolism: The Role of Nuclear Receptors (2003) (194)
- NUBIScan, an in silico approach for prediction of nuclear receptor response elements. (2002) (192)
- Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. (2005) (176)
- Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. (2004) (168)
- Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia (2018) (167)
- cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. (1989) (166)
- Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man. (1988) (162)
- Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. (1988) (160)
- The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. (1990) (160)
- Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. (1988) (157)
- Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. (2002) (157)
- Maternal Immune Activation and Neuropsychiatric Illness: A Translational Research Perspective. (2018) (154)
- Prenatal Immune Challenge Is an Environmental Risk Factor for Brain and Behavior Change Relevant to Schizophrenia: Evidence from MRI in a Mouse Model (2009) (153)
- Neural basis of psychosis-related behaviour in the infection model of schizophrenia (2009) (153)
- Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. (1991) (149)
- Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria (1996) (143)
- Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily. (1993) (142)
- Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression (2008) (141)
- Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. (1992) (141)
- Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. (1987) (140)
- MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. (1987) (139)
- Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy (2008) (139)
- Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. (1998) (138)
- Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model (2018) (137)
- Critical review of the safety assessment of titanium dioxide additives in food (2018) (136)
- Omics and drug response. (2013) (134)
- The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. (1986) (131)
- Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: Implications for schizophrenia (2006) (130)
- CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). (2000) (130)
- N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers. (1993) (129)
- Pregnane X Receptor Is a Target of Farnesoid X Receptor* (2006) (129)
- Transgenerational transmission and modification of pathological traits induced by prenatal immune activation (2017) (125)
- Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations. (1996) (125)
- Decreased red cell uroporphyrinogen I synthetase activity in intermittent acute porphyria. (1972) (124)
- Prenatal and postnatal maternal contributions in the infection model of schizophrenia (2006) (122)
- Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver. (1990) (121)
- Role of P450IID6, the target of the sparteine‐debrisoquin oxidation polymorphism, in the metabolism of imipramine (1991) (120)
- Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine (2006) (117)
- Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome. (2014) (116)
- Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. (1999) (115)
- Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism. (1988) (114)
- Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia. (2010) (112)
- Characterisation of theophylline metabolism in human liver microsomes. (1987) (111)
- Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs (1996) (110)
- Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes. (1997) (108)
- Gut Vagal Afferents Differentially Modulate Innate Anxiety and Learned Fear (2014) (108)
- Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation (2019) (108)
- Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry (2018) (108)
- Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol. (1986) (107)
- Prenatal Immune Activation Interacts with Genetic Nurr1 Deficiency in the Development of Attentional Impairments (2012) (107)
- Three haplotypes associated with CYP2A6 phenotypes in Caucasians (2005) (106)
- Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders (2017) (106)
- The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. (1989) (105)
- Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies (2016) (104)
- Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia (2009) (102)
- Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia (2016) (101)
- A multifamily study on the relationship between CYP2C19 genotype and s-mephenytoin oxidation phenotype. (1995) (101)
- Isolation and characterization of rough endoplasmic reticulum associated with mitochondria from normal rat liver. (1981) (96)
- Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex (2015) (95)
- The International Society for Developmental Psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development. (2006) (95)
- Cytochrome P450 of small intestinal epithelial cells. Immunochemical characterization of the increase in cytochrome P450 caused by phenobarbital. (1985) (93)
- Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging (2015) (91)
- Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. (1988) (91)
- Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis (2010) (89)
- Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms (2017) (88)
- Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver (2006) (88)
- In vitro characterization of the human cytochrome P‐450 involved in polymorphic oxidation of propafenone (1989) (88)
- Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models (2012) (88)
- Age-related accumulation of Reelin in amyloid-like deposits (2009) (86)
- Identification of the xenosensors regulating human 5-aminolevulinate synthase (2004) (86)
- Hepatic Monooxygenase Activities in Subjects With a Genetic Defect in Drug Oxidation (1983) (85)
- A novel pregnane X receptor and S14‐mediated lipogenic pathway in human hepatocyte (2009) (83)
- Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: Relationship to the presence of immunoidentified cytochrome P‐450IID1 (1990) (82)
- Pharmacogenetics: the slow, the rapid, and the ultrarapid. (1994) (82)
- Patients with type ii autoimmune hepatitis express functionally intact cytochrome P‐450 db1 that is inhibited by LKM‐1 autoantibodies in vitro but not in vivo (1990) (79)
- In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase (2007) (79)
- Cytochrome P450 enzymes (2012) (79)
- Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation (2017) (78)
- Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melanogaster expressed in the nervous system and the gut. (1996) (77)
- Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes (2008) (77)
- Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (1994) (75)
- Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. (1985) (75)
- Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders. (2014) (74)
- Evidence for two closely related isozymes of arylamine N‐acetyltransferase in human liver (1989) (74)
- Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene. (1993) (72)
- An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis. (1995) (71)
- Increased risk for hepatocellular carcinoma in NAT2-slow acetylators and CYP2D6-rapid metabolizers. (1996) (70)
- Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Activate a Drug-responsive Enhancer of the Murine 5-Aminolevulinic Acid Synthase Gene* (2003) (70)
- Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice (2013) (70)
- A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity (2009) (70)
- Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products. (1998) (69)
- Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency. (1987) (69)
- DANGEROUS INTERACTION BETWEEN AMIODARONE AND QUINIDINE (1982) (69)
- Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation (2019) (68)
- Long-term pathological consequences of prenatal infection: beyond brain disorders. (2015) (67)
- Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation. (1989) (67)
- Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). (2000) (67)
- Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers. (1984) (67)
- Anti-inflammatory signaling in schizophrenia (2011) (66)
- Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation (2014) (66)
- Hemoprotein catabolism during stimulation of microsomal lipid peroxidation. (1972) (65)
- Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation (2019) (63)
- Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450* (2002) (61)
- Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation (2020) (60)
- Neuronal activity increases translocator protein (TSPO) levels (2020) (60)
- Spreading Depression Triggers Headache by Activating Neuronal Panx 1 Channels (60)
- Extent and character of phenobarbital-mediated changes in gene expression in the liver. (1997) (60)
- The Roots of Autism and ADHD Twin Study in Sweden (RATSS) (2014) (59)
- Mouse models of maternal immune activation: Mind your caging system! (2018) (59)
- Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring (2008) (59)
- The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). (1992) (59)
- Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo (1985) (59)
- Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri). (1998) (59)
- Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. (2000) (59)
- Priming of metabolic dysfunctions by prenatal immune activation in mice: relevance to schizophrenia. (2013) (58)
- Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability (2020) (58)
- Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency. (2010) (57)
- DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond (2016) (57)
- Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency. (1987) (56)
- Joint Effects of Exposure to Prenatal Infection and Peripubertal Psychological Trauma in Schizophrenia (2017) (56)
- Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine (2004) (56)
- Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males. (1993) (55)
- Sulfonylureas and Glinides Exhibit Peroxisome Proliferator-Activated Receptor γ Activity: A Combined Virtual Screening and Biological Assay Approach (2007) (55)
- Genome-Wide Transcriptional Profiling and Structural Magnetic Resonance Imaging in the Maternal Immune Activation Model of Neurodevelopmental Disorders (2016) (55)
- Drugs Mediate the Transcriptional Activation of the 5-Aminolevulinic Acid Synthase (ALAS1) Gene via the Chicken Xenobiotic-sensing Nuclear Receptor (CXR)* (2002) (55)
- Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. (2002) (55)
- Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation. (1990) (54)
- Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency (2017) (53)
- Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro. (2001) (52)
- Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies. (1990) (52)
- Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers (2009) (51)
- Enzymatic Dissociation Induces Transcriptional and Proteotype Bias in Brain Cell Populations (2020) (51)
- Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. (1983) (50)
- Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. (2001) (50)
- Genetic polymorphism of debrisoquine oxidation: restriction fragment analysis and allele-specific amplification of mutant alleles of CYP2D6. (1991) (49)
- N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits. (1989) (49)
- Truncated human P450 2D6: expression in Escherichia coli, Ni(2+)-chelate affinity purification, and characterization of solubility and aggregation. (1995) (49)
- Induction of delta-aminolevulinate synthase and cytochrome P-450 hemoproteins in hepatocyte culture. Effect of glucose and hormones. (1981) (48)
- Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (1991) (48)
- Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor (2007) (48)
- Perinatal programming by inflammation (2017) (48)
- Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro. (1975) (47)
- Isolation and characterization of an arylalkylamine N‐acetyltransferase from Drosophila melanogaster (1995) (47)
- Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes. (1989) (47)
- [Heme biosynthesis]. (1975) (46)
- A Conserved Nuclear Receptor Consensus Sequence (DR-4) Mediates Transcriptional Activation of the Chicken CYP2H1 Gene by Phenobarbital in a Hepatoma Cell Line* (2000) (45)
- Amylin at the interface between metabolic and neurodegenerative disorders (2015) (44)
- Drug regimen compliance : issues in clinical trials and patient management (1999) (44)
- Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation. (1990) (43)
- Potent Inhibition of Cytochrome P450IID6 (Debrisoquin 4‐Hydroxylase) by Flecainide In Vitro and In Vivo (1990) (42)
- Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation (2018) (42)
- Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine‐type polymorphism of drug oxidation (1984) (41)
- N‐Acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus (1996) (40)
- Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). (2010) (40)
- Transcriptional Activation of Cytochrome P450 CYP2C45 by Drugs Is Mediated by the Chicken Xenobiotic Receptor (CXR) Interacting with a Phenobarbital Response Enhancer Unit* (2002) (40)
- The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals (2004) (39)
- Isolation of a subfraction of rough endoplasmic reticulum closely associated with mitochondria. Evidence for its role in cytochrome P450 synthesis. (1978) (38)
- Polymorphisms of N-acetyltransferase genes. (1992) (38)
- Schizophrenia‐relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency (2011) (38)
- PYY3 – 36: Beyond food intake (2015) (38)
- Cytochrome P450 of small intestinal epithelial cells (1985) (36)
- Altered GSK3β signaling in an infection-based mouse model of developmental neuropsychiatric disease (2013) (36)
- Purification and characterization of a human liver arylacetamide deacetylase. (1991) (36)
- Behavioral animal models of antipsychotic drug actions. (2012) (35)
- Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers (2004) (35)
- LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M400453-JLR200 (2005) (34)
- Behavioral Effects of the Benzodiazepine-Positive Allosteric Modulator SH-053-2’F-S-CH3 in an Immune-Mediated Neurodevelopmental Disruption Model (2015) (33)
- Primary liver carcinoma in two sisters with acute intermittent porphyria. (1990) (33)
- Chronic high fat diet consumption impairs sensorimotor gating in mice (2013) (33)
- Genomics and the prediction of xenobiotic toxicity. (2002) (33)
- Role of heme in cytochrome P450 transcription and function in mice treated with lead acetate. (1996) (33)
- Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. (2002) (32)
- Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis. (1996) (31)
- Hereditary hepatic porphyrias. (1973) (31)
- Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver. (1989) (30)
- Prenatal exposure to TiO2 nanoparticles in mice causes behavioral deficits with relevance to autism spectrum disorder and beyond (2018) (30)
- Expression of the CS- and US-Pre-Exposure Effects in the Conditioned Taste Aversion Paradigm and Their Abolition Following Systemic Amphetamine Treatment in C57BL6/J Mice (2004) (30)
- Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation. (1986) (29)
- Individual and combined effects of maternal anemia and prenatal infection on risk for schizophrenia in offspring (2016) (29)
- Steric configuration and polymorphic oxidation of lipophilic beta-adrenoceptor blocking agents: in vivo — in vitro correlations (1985) (29)
- Interaction between amiodarone and lidocaine. (1996) (29)
- Role of haem in the induction of cytochrome P-450 by phenobarbitone. Studies in chick embryos in ovo and in cultured chick embryo hepatocytes. (1981) (29)
- Intermittent Acute Porphyria (1973) (27)
- Targeting Glia with N-Acetylcysteine Modulates Brain Glutamate and Behaviors Relevant to Neurodevelopmental Disorders in C57BL/6J Mice (2015) (27)
- Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture (1983) (27)
- Administration of the Y2 Receptor Agonist PYY3-36 in Mice Induces Multiple Behavioral Changes Relevant to Schizophrenia (2013) (26)
- Polymorphism of human acetyltransferases. (1994) (26)
- Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type (2004) (26)
- Abdominal Vagal Afferents Modulate the Brain Transcriptome and Behaviors Relevant to Schizophrenia (2018) (25)
- Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. (2001) (25)
- Frontal-Subcortical Protein Expression following Prenatal Exposure to Maternal Inflammation (2011) (25)
- A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency (1995) (24)
- Stereo- and regioselectivity of hepatic oxidation in man — Effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation (2004) (24)
- Neonatal Levels of Inflammatory Markers and Later Risk of Schizophrenia (2015) (24)
- Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR. (2009) (24)
- Effects of rifampicin on global gene expression in human small intestine (2007) (24)
- Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. (1998) (24)
- Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction. (1991) (23)
- Disruption of the US pre-exposure effect and latent inhibition in two-way active avoidance by systemic amphetamine in C57BL/6 mice (2007) (23)
- Challenges and opportunities of a-priori and a-posteriori variability in maternal immune activation models (2019) (22)
- A Link between cholesterol levels and phenobarbital induction of cytochromes P450. (2002) (22)
- The Sterolgene v0 cDNA microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism (2008) (22)
- Association of Extracolonic Manifestations of Familial Adenomatous Polyposis with Acetylation Phenotype in a Large FAP Kindred (1997) (22)
- Microglia and schizophrenia: where next? (2017) (22)
- Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency (2005) (21)
- Regulation of human liver δ‐aminolevulinic acid synthase by bile acids (2007) (21)
- Adolescence is a sensitive period for prefrontal microglia to act on cognitive development (2022) (21)
- Transgenerational modification of dopaminergic dysfunctions induced by maternal immune activation (2020) (21)
- Effects of 5-methylpyrazole-3-carboxylic acid on adipose tissue. I. Inhibition of lipolysis, effects on glucose, fructose, and glycogen metabolism in vitro and comparison with insulin. (1967) (20)
- Human P-450 genes: evolution, regulation and possible role in carcinogenesis. (1987) (20)
- The neuropathological contribution of prenatal inflammation to schizophrenia (2011) (19)
- Abnormal context–reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia (2015) (19)
- Nurr1 is not essential for the development of prepulse inhibition deficits induced by prenatal immune activation (2011) (19)
- Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis (2021) (19)
- Heme and hemoprotein catabolism during stimulation of microsomal lipid peroxidation. (1973) (19)
- Mechanisms of phenobarbital-type induction of cytochrome P-450 isozymes. (1987) (19)
- Intermittent acute porphyria: the enzymatic defect. (1974) (19)
- Multiple Mutations of the Human Cytochrome P 450 IID 6 Gene ( CYP 2 D 6 ) in Poor Metabolizers of Debrisoquine (2001) (19)
- Stereoselective Metabolism of Bufuralol Racemate and Enantiomers in Human Liver Microsomes (2002) (18)
- Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method. (1990) (18)
- Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers (2005) (18)
- Zinc mesoporphyrin represses induced hepatic 5‐aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria (2001) (18)
- The Y2 receptor agonist PYY(3-36) increases the behavioural response to novelty and acute dopaminergic drug challenge in mice. (2014) (17)
- Endo-Xenobiotic Crosstalk and the Regulation of Cytochromes P450 (2007) (17)
- Effect of Griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic nodules. (1981) (17)
- Cognitive effects of subdiaphragmatic vagal deafferentation in rats (2017) (16)
- Effects of phenobarbital, beta-naphthoflavone, dexamethasone, and formamidoxime on the turnover of inducible microsomal proteins in cultured hepatocytes. (1981) (16)
- Nucleotide sequence of rabbit NAT2 encoding polymorphic liver arylamine N-acetyltransferase (NAT). (1990) (16)
- Comparison of the long-term consequences of withdrawal from repeated amphetamine exposure in adolescence and adulthood on information processing and locomotor sensitization in mice (2013) (16)
- Nucleotide sequence of rabbit NAT1 encoding monomorphic arylamine N-acetyltransferase. (1990) (16)
- Induction of cytochrome P450 by phenobarbital in rat liver visualized by monoclonal antibody immunoelectron microscopy in situ. (1990) (15)
- Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders (2020) (14)
- The substituted pyridines metyrapone and nicotinamide are inducers of 5-aminolevulinate synthase and cytochrome P-450 in hepatocyte culture. (1982) (14)
- Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations (2003) (14)
- Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice (2011) (14)
- Effects of 5-methylpyrazole-3-carboxylic acid on adipose tissue. II. Antilipolytic and hypoglycemic effects in vivo. (1967) (13)
- Regulation of human liver delta-aminolevulinic acid synthase by bile acids. (2007) (13)
- Premenstrual exacerbations in hepatic porphyria: prevention by intermittent administration of an LH-RH agonist in combination with a gestagen. (1989) (12)
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice (2015) (12)
- The pathogenesis of tumour hypoglycaemia: Blocks of hepatic glucose release and of adipose tissue lipolysis (1967) (12)
- Effects of withdrawal from repeated amphetamine exposure in peri-puberty on neuroplasticity-related genes in mice (2013) (12)
- Acetylation of Serotonin in the Rabbit Pineal Gland: An N‐Acetyltransferase with Properties Distinct from NAT1 and NAT2 Is Responsible (1991) (11)
- Hypolipidemic effects of silymarin are not mediated by the peroxisome proliferator-activated receptor alpha (2007) (11)
- In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. (2003) (11)
- Biosynthesis of rat liver cytochrome P-450 in mitochondria-associated rough endoplasmic reticulum and in rough microsomes in vivo. (1984) (11)
- Drug Regimen Compliance (1998) (10)
- Oleoylethanolamide‐induced anorexia in rats is associated with locomotor impairment (2018) (10)
- Abdominal vagal deafferentation alters affective behaviors in rats. (2019) (10)
- Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future". (2020) (9)
- Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. (2005) (9)
- Pharmacogenetics in the Field of Heme Metabolism: Drug Sensitivity in Hereditary Hepatic Porphyria (1978) (9)
- 32P-postlabelling studies on the DNA adducts of the food mutagens/carcinogens IQ and PhIP--adduct formation in a chemical system, and by rat and human metabolism. (1993) (9)
- Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions (2018) (8)
- Drug sensitivity in hereditary hepatic porphyria. (1978) (8)
- Identification of New Human CYP 2 C 19 Alleles ( CYP 2 C 19 * 6 and CYP 2 C 19 * 2 B ) in a Caucasian Poor Metabolizer of Mephenytoin 1 (1998) (8)
- Pyridoxine-responsive primary acquired sideroblastic anaemia. In vitro and in vivo effects of vitamin B6 on decreased 5-aminolaevulinate synthase activity. (2009) (8)
- Response to Comment on "Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice" (2013) (7)
- Intermittent acute porphyria. Clinical and biochemical studies of disordered heme biosynthesis. (1973) (7)
- Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide. (1976) (7)
- Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects. (1980) (7)
- Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems (2021) (7)
- Systems medicine, personalized health and therapy. (2015) (7)
- [Acute hepatic porphyria and its neurological syndrome]. (1996) (6)
- REGULATORY CROSSTALK BETWEEN DRUG METABOLISM AND LIPID HOMEOSTASIS: CAR AND PXR INCREASE INSIG-1 EXPRESSION (2007) (6)
- Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias (1978) (6)
- COGNITIVE IMPAIRMENT FOLLOWING PRENATAL IMMUNE CHALLENGE IN MICE CORRELATES WITH PREFRONTAL CORTICAL AKT1 DEFICIENCY (2010) (6)
- [Persistent disorders of ACTH secretion following surgery of an adrenal cortex adenoma in 3 cases of Cushing's syndrome]. (1967) (5)
- Cytochrome P 450 of Small Intestinal (1985) (5)
- New serological evidence points toward an infectious route to bipolar disorder. (2014) (5)
- Dual ligand binding of pyridylalkanamides to microsomal cytochrome P-450. (1986) (5)
- Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology". (2017) (5)
- 8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016 (2017) (4)
- [Thoughts on the qualitative improvement of self medication]. (1986) (4)
- Pharmacogenomics, Second Edition (2005) (4)
- Dependency of prepulse inhibition deficits on baseline startle reactivity in a mouse model of the human 22q11.2 microdeletion syndrome (2018) (4)
- Author Proof A Invited ArticleQ 12 The International Society for Developmental Psychobiology Annual Meeting Impact of Early Life Experiences on Brain and Behavioral Development (2006) (4)
- Introduction to the Theme "Old and New Toxicology: Interfaces with Pharmacology". (2021) (3)
- Neuroinflammation and Schizophrenia (2020) (3)
- Metabolic Diseases of the Liver (1975) (3)
- Hepatic porphyrias: new findings on the nature of metabolic defects. (1976) (3)
- LATE PRENATAL IMMUNE ACTIVATION IN MICE LEADS TO BEHAVIORAL ABNORMALITIES RELEVANT TO THE NEGATIVE SYMPTOMS OF SCHIZOPHRENIA (2010) (3)
- Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. (2003) (3)
- Comment on: “The serological evidence for maternal influenza as risk factor for psychosis in offspring is insufficient: Critical review and meta-analysis” (2017) (2)
- Long-term behavioural and neurochemical consequences of prenatal immune activation: Towards an immunoprecipitated neurodevelopmental animal model of schizophrenia schizophrenia (2005) (2)
- Susceptibility and resilience to maternal immune activation are associated with differential expression of endogenous retroviral elements (2022) (2)
- Placebos and Nocebos (1989) (2)
- Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging (2015) (2)
- Introduction to the Theme "Cancer Pharmacology". (2016) (2)
- Welcome to the Journal of Personalized Medicine: A New Open-Access Platform for Research on Optimal Individual Healthcare (2011) (2)
- Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders (2021) (2)
- Developmental Immune Activation Models with Relevance to Schizophrenia (2015) (2)
- Altered Local Beta and Gamma Synchronization in Prefrontal Cortex of Mice with Redox Dysregulation or Maternal Immune Activation (2011) (2)
- Transport and metabolism of glucose, insulin sensitivity and lipolysis of epididymal adipose tissue of alloxan-diabetic rats after prolonged incubation in vitro. (1968) (2)
- The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy. “The Odyssey from Hope to Practice”, Santorini, Greece, 30 September–3 October 2018 (2018) (1)
- Prediction of cis-regulatory elements for drug-activated transcription factors in the regulation of drug-metabolising enzymes and drug transporters (2006) (1)
- 117.2 Translational Evaluation of Translocator Protein (TSPO) as a Marker of Neuroinflammation in Schizophrenia (2017) (1)
- Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development". (2018) (1)
- [Clinically significant inherited differences in the mode of action of drugs]. (1982) (1)
- Second Annual Meeting of the European Association for the Study of Diabetes abstracts (1966) (1)
- 14:30 DOPAMINE AND SCHIZOPHRENIA. DO ALL ROADS LEAD TO DOPAMINIE OR IS IT THE START OF THE JOURNEY? EVIDENCE FROM ANIMAL MODELS (2012) (1)
- PORPHYRIA AND LIVER CANCER. REPLY (1991) (1)
- Creation of the Swiss group of Pharmacogenomics and personalised Therapy (SPT) (2017) (1)
- The Psychotic Face of the Immune System: Inflammation and Schizophrenia (2013) (1)
- DRUG-MEDIATED INDUCTION OF CYTOCHROME P450 HEMOPROTEINS IN PRIMARY CHICK EMBRYO HEPATOCYTE CULTURE (1980) (1)
- Porphyrin biosynthesis. Enhancement of the fractional catabolic rate of microsomal haem in chemically induced porphyria. (1971) (1)
- Human Cytochromes P450: Regulation and Functional Variability (1995) (1)
- The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics (2003) (1)
- Double trouble: Prenatal immune activation in stress sensitive offspring (2021) (1)
- Transport and metabolism of glucose, insulin sensitivity and lipolysis of epididymal adipose tissue of alloxan-diabetic rats after prolonged incubationin vitro (1968) (1)
- STRUCTURAL AND FUNCTIONAL INTERACTION OF ROUGH ENDOPLASMIC RETICULUM (RER) AND MITOCHONDRIA DURING SYNTHESIS OF HEPATIC CYTOCHROME P450 (1977) (1)
- [Drug interactions. A selection for dental practice]. (1989) (1)
- Sulfonylureas and Glinides Exhibit PPARγ Activity: A Combined Virtual Screening and Biological Assay Approach* (2006) (1)
- Characterisation oftheophylline metabolism inhumanliver microsomes (1987) (1)
- Molecular mechanisms of variation in cytochrome p 450 function in human liver use of a human liver bank (1985) (1)
- Letter to the Editor re: Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration (2018) (1)
- Cytochrome P450 (CYP) Monooxygenase Superfamily (2008) (1)
- Maternal Immune Activation and Retrotransposition in Neurodevelopmental Disorders (2021) (1)
- Introduction to the Theme "New Therapeutic Targets". (2019) (1)
- 4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation. (2019) (1)
- An A-Z Guide to Pharmacogenomics. (2007) (1)
- Motor patterns in an isolated arterially-perfused small intestine of the mouse (1998) (1)
- SULFONYLUREAS AND GLINIDES AS NEW PPARγ AGONISTS: VIRTUAL SCREENING AND BIOLOGICAL ASSAYS (2007) (1)
- F21. THE PHOSPHODIESTERASE-9 INHIBITOR BI 409306 ATTENUATES SOCIAL INTERACTION AND DOPAMINERGIC DEFICITS IN ADULT OFFSPRING OF POLY(I:C)-BASED MATERNAL IMMUNE ACTIVATION NEURODEVELOPMENTAL MOUSE MODEL (2019) (1)
- [Which drug interactions are clinically relevant?]. (1979) (0)
- Neuronal activity increases translocator protein (TSPO) levels in the adult mouse brain (2020) (0)
- T179. WHEN TOO LITTLE IS TOO MUCH: TEMPORARY PREFRONTAL MICROGLIA DEFICIENCY DURING ADOLESCENCE IMPAIRS ADULT BRAIN FUNCTIONS (2020) (0)
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice (2015) (0)
- Giovanoli of Prenatal Immune Activation in Mice Stress in Puberty Unmasks Latent Neuropathological Consequences (2013) (0)
- Cytochrome P450 Monooxygenase 2C9 (2008) (0)
- Title Frontal-subcortical protein expression following prenatalexposure to maternal inflammation (2011) (0)
- 1029 – APOCYTOCHROME P-450: REGULATOR OF CYTOCHROME P-450 SYNTHESIS? (1977) (0)
- Correction: Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis (2021) (0)
- Stimulation of DNA synthesis and mitotic activity of chick embryo hepatocytes in primary culture (1984) (0)
- Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders (2022) (0)
- Preface: Circles in drug research (1996) (0)
- Abstract # 3223 Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation (2019) (0)
- [Nature, chemistry and modern medicine]. (1985) (0)
- Heme Synthesis and Degradation: Its Role in Predicting Drug Toxicity — Opening Remarks (1982) (0)
- S.16.03 Infection-based neurodevelopmental animal models for schizophrenia-like brain and behavioural pathology (2009) (0)
- 15 Prenatal infections and long-term mental outcome: Modeling schizophrenia-related dysfunctions using the prenatal Polyl:C model in mice (2011) (0)
- Poster #M12 REWARD DEFICITS IN THE MATERNAL IMMUNE ACTIVATION MODEL (2014) (0)
- Poster #S14 PRENATAL IMMUNE ACTIVATION IMPAIRS SYNAPTIC DEVELOPMENT IN THE ABSENCE OF OVERT GLIAL PATHOLOGY (2014) (0)
- F39. MATERNAL IMMUNE ACTIVATION MODELS: MIND YOUR CAGING SYSTEMS! (2018) (0)
- [Drug interactions]. (1979) (0)
- Abstract # 3212 Maternal immune activation induces transgenerational effects on prefrontal cortex structure and function (2019) (0)
- [Polypragmasy and polypharmacy; perspective on the restrictions to fewer therapeutic agents (author's transl)]. (1976) (0)
- CLINICAL ASPECTS OF PHARMACOGENETICS AND PHARMACOGENOMICS : PRESENT AND FUTURE (2007) (0)
- Metabolism of adipose tissue in normal and alloxan-diabetic rats and in rats refed after starvation during prolonged incubation in vitro. (1966) (0)
- Cytochrome P450 Monooxygenase 1A1-2 (2008) (0)
- Cytochrome P450 Monooxygenase 2C19 (2008) (0)
- Rapid Publication (0)
- BRIDGING EPIDEMIOLOGY AND RODENT MODELS: MATERNAL INFLAMMATION AND PSYCHOBIOLOGY OF OFFSPRING (2012) (0)
- Poster #16 SYNERGISTIC INTERACTIONS BETWEEN PRENATAL INFECTION AND PUBERTAL STRESS IN THE DEVELOPMENT OF SCHIZOPHRENIA-RELEVANT ABNORMALITIES (2012) (0)
- Cytochrome P450 Monooxygenase 3A4-5 (2008) (0)
- Preface: The Search for Consensus (1997) (0)
- Effect on Induction of Polysubstrate Monooxygenase Activity (1984) (0)
- 14:15 ONTOGENY OF COGNITIVE IMPAIRMENT FOLLOWING PRENATAL INFECTION (2012) (0)
- The effects of systemic amphetamine treatment on the USpre-exposure effect and latent inhibition in CS7BL/6J mice (2005) (0)
- Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation (2018) (0)
- CHAPTER 3:Developmental Neuroimmune Mechanisms in Schizophrenia (2015) (0)
- MOLECULAR CLONING OF A NOVEL ESTERASE INVOLVED IN THE METABOLIC ACTIVATION OF ARYLAMINE CARCINOGENS WITH HIGH SEQUENCE SIMIMI'N TO HORMONE-SENSITJYE LIPASE* (1994) (0)
- Rodent Models of Multiple Environmental Exposures with Relevance to Schizophrenia (2016) (0)
- [Interindividual differences in the reaction to drugs and poisons]. (1992) (0)
- P.3.f.003 Prenatal immune activation induces primary defects in dopaminergic development relevant to schizophrenia (2009) (0)
- Susceptibility and Resilience in a Mouse Model of Maternal Immune Activation (2020) (0)
- Studies on the molecular basis of polymorphic drug oxidation (debrisoquine/sparteine-type) in man (1985) (0)
- INFECTION-INDUCED WORKING MEMORY DEFICITS WITHOUT INFLUENCING ADULT HIPPOCAMPAL NEUROGENESIS (2010) (0)
- Abstract # 3224 Role of microglia deficiency in brain maturation and behaviors relevant to neurodevelopmental disorders (2019) (0)
- P.2.006 Ontogeny of cognitive impairment following prenatal infection (2012) (0)
- Abstract #4387 Modeling prenatal depression in mice: Behavioral and molecular consequences and the impact of antidepressant treatment (2019) (0)
- Poster #M240 BEHAVIORAL EFFECTS OF THE NOVEL BENZODIAZEPINE POSITIVE ALLOSTERIC MODULATOR SH-053-2′F-S-CH3 IN AN IMMUNE-MEDIATED NEURODEVELOPMENTAL DISRUPTION MODEL (2014) (0)
- [Drug interactions. A selection for dental practice]. (1988) (0)
- Cytochrome P450 Monooxygenase 2D6 (2008) (0)
- Cytochrome P450 Monooxygenase 2B6 (2008) (0)
- [Bioavailability of 3 theophylline delayed-release preparations. Comparison of theophylline concentrations in the serum and saliva in the steady state]. (1982) (0)
- 239. Prenatal Immune Activation Modifies Behavioral Phenotypes Across Multiple Generations (2018) (0)
- MATERNAL IMMUNE ACTIVATION DURING PREGNANCY MODULATES FETALDOPAMINERGIC DEVELOPMENT: IMPLICATIONS FOR THE ETIOLOGY OF SCHIZOPHRENIA (2008) (0)
- Late prenatal immune activation in mice induces transgenerational effects via the maternal and paternal lineages. (2022) (0)
- M180. SUSCEPTIBILITY AND RESILIENCE IN A MOUSE MODEL OF MATERNAL IMMUNE ACTIVATION (2020) (0)
- Poster #17 TRANSIENT NEUROINFLAMMATION MEDIATES PATHOLOGICAL SYNERGISMS BETWEEN PRENATAL INFECTION AND PUBERTAL STRESS (2012) (0)
- [Metabolism of adipose tissue of normal, alloxan-diabetic and fasted-refed rats during prolonged incubation in vitro]. (1966) (0)
- PXR and CAR: more than meets the eye (2005) (0)
- 40.2 MATERNAL IMMUNE ACTIVATION LEADS TO INCREASED LEVELS OF INFLAMMATORY CYTOKINES IN THE ABSENCE OF OVERT MICROGLIA ANOMALIES IN THE MIDBRAIN (2018) (0)
- Effect of Drugs and Chemicals on δ-Aminolevulinic Acid Synthase, the Rate-limiting Enzyme of Heme Synthesis (1982) (0)
- S188. The Phosphodiesterase-9 Inhibitor BI 409306 Attenuates Social Interaction and Dopaminergic Deficits in Adult Offspring of poly(I:C)-Based Maternal Immune Activation Neurodevelopmental Mouse Model (2019) (0)
- T178. MICROPIPETTE-GUIDED DRUG ADMINISTRATION (MDA) METHOD AS A NOVEL PHARMACOLOGICAL TREATMENT METHOD IN MICE: PRECLINICAL VALIDATION USING RISPERIDONE IN THE MATERNAL IMMUNE ACTIVATION MODEL OF NEURODEVELOPMENTAL DISORDERS (2020) (0)
- Prenatal immune priming of metabolic dysfunctions related to schizophrenia (2011) (0)
- 190 POLYMORPHIC N-ACETYLTRANSFERASE 2 IS INHIBITED BY ACETAMINOPHEN IN VITRO & IN VIVO (1996) (0)
- In vitro, in vivo, and in silico Approaches to Predict Induction of Drug Metabolism (2007) (0)
- Poster #S19 PERIPUBERTAL HIGH FAT DIET EXPOSURE LEADS TO A DOPAMINE-DEPENDENT DISRUPTION OF SENSORIMOTOR GATING IN ADULTHOOD (2014) (0)
- Apocytochrome P-450: Reconstitution of (2016) (0)
- 4th ESPT summer school: precision medicine and personalised health. (2019) (0)
- F191. Maternal Immune Activation Models: Mind Your Caging Systems! (2018) (0)
- 3.2 PARVALBUMIN INTERNEURON IMPAIRMENT INDUCED BY OXIDATIVE STRESS AS A COMMON PATHOLOGICAL MECHANISM IN ANIMAL MODELS OF SCHIZOPHRENIA (2018) (0)
- [Drug interactions]. (1976) (0)
- The neurodevelopmental impact of prenatal infection at different times during pregnancy: Implications for pathological symptom profiles fit the offspring (2008) (0)
- Maternal Immune Activation Induces Transgenerational Effects on Prefrontal Cortex Structure and Function (2020) (0)
- 6.1 STUDY OF ALTERED NEUROIMMUNITY IN PSYCHOSIS USING PET-BASED IMAGING OF THE TRANSLOCATOR PROTEIN 18 KDA: PROMISES, PITFALLS, AND FUTURE DIRECTIONS (2018) (0)
- Introduction to the Theme "New Insights, Strategies, and Therapeutics for Common Diseases". (2021) (0)
- PM489. Altered GABAergic function following prenatal immune activation in mice: modulation by chronic lurasidone treatment. (2016) (0)
- TRANSIENT NEUROINFLAMMATION IS A KEY MECHANISM MEDIATING THE NEUROPATHOLOGICAL INTERACTIONS BETWEEN PRENATAL IMMUNE CHALLENGE AND PERIPUBERTAL STRESS (2014) (0)
- Prenatal immune challenge causes frontal-subcortical proteome changes relevant to schizophrenia and autism (2010) (0)
- P.3.f.002 Synergistic interactions between prenatal immune challenge and peri-pubertal stress in the disruption of adult behavioural functions (2011) (0)
- Debrisoquine hydroxylation polymorphism: comparison of debrisoquine- and dextromethorphan-test and restriction fragment analysis in healthy volunteers (1990) (0)
- Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care". (2022) (0)
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