Utako Okamoto | Academic Influence

Utako Okamoto's AcademicInfluence.com Rankings

Utako Okamoto

Philosophy

#12249

World Rank

#16981

Historical Rank

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#9087

World Rank

#11464

Historical Rank

philosophy Degrees

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Philosophy

Utako Okamoto's Degrees

Bachelors Medicine University of Tokyo
PhD Medical Science Kyoto University

Why Is Utako Okamoto Influential?

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According to Wikipedia, Utako Okamoto was a Japanese medical doctor working as a medical scientist who discovered tranexamic acid in the 1950s in her quest to find a drug that would treat bleeding after childbirth . After publishing results in 1962 she became a chair at Kobe Gakuin University, where she worked from 1966 until her retirement in 1990. Okamoto's career was hampered by a very male dominated environment. During her lifetime she was unable to persuade obstetricians at Kobe to trial the antifibrinolytic agent, which had become a drug on the WHO list of essential medicines in 2009. She lived to see the 2010 beginning of the study of tranexamic acid in 20 000 women with post-partum haemorrhage, but died before its completion in 2016 and the publication of tranexamic acids fatality preventing results in 2017, that she had predicted.

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Utako Okamoto's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

AMINO-METHYL-CYCLOHEXANE-CARBOXYLIC ACID: AMCHA (1962) (146)
AN ACTIVE STEREO-ISOMER (TRANS-FORM) OF AMCHA AND ITS ANTIFIBRINOLYTIC (ANTIPLASMINIC) ACTION IN VITRO AND IN VIVO. (1964) (106)
Enzyme-controlling medicines: introduction. (1997) (90)
SYNTHETIC INHIBITORS OF FIBRINOLYSIS: IN VITRO AND IN VIVO MODE OF ACTION (1968) (67)
A SUPPRESSING EFFECT OF ε-AMINO-N-CAPROIC ACID ON THE BLEEDING OF DOGS, PRODUCED WITH THE ACTIVATION OF PLASMIN IN THE CIRCULATORY BLOOD (1959) (46)
Development of potent and selective plasmin and plasma kallikrein inhibitors and studies on the structure-activity relationship. (2000) (29)
Plasminogen-Activator in Human Early Milk: Its Partial Purification and Characterization (1981) (27)
Synthesis of chromogenic substrates specific for human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE). (1982) (26)
Human Leukocyte Elastase-Like Proteinase Purified by Affinity Chromatography with Suc-L-Tyr-D-Leu-D-Val-pNA, and Its Identification with Human Spleen Fibrinolytic Proteinase (1984) (24)
Development of active center-directed plasmin and plasma kallikrein inhibitors and studies on the structure-inhibitory activity relationship. (1993) (21)
Amino-methyl-cyclohexane-carboxylic acid A new potent inhibitor of fibrinolysis (1962) (20)
Development of plasma kallikrein selective inhibitors. (1992) (19)
Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors. (2001) (16)
Development of active center-directed inhibitors against plasmin. (1991) (15)
Synthesis of substrates specific for human spleen fibrinolytic proteinase (SFP). (2009) (14)
FRACTIONATION OF PLASMINOGEN ACTIVATOR AND PROACTIVATOR IN TISSUE AND BLOOD BY GEL FILTRATION. (1964) (12)
Convenient purification of human spleen fibrinolytic proteinase (SFP) and human leucocyte elastase by affinity chromatography. (1982) (12)
A NEW METHOD OF DETERMINATION OF EPSILON AMINOCAPROIC ACID AND AMINOMETHYL CYCLOHEXANE CARBOXYLIC ACID. (1964) (11)
A new polypeptide substrate, Suc-Tyr-Leu-Val-pNA, specific for spleen fibrinolytic proteinase (SFP). (1980) (11)
Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein. (1992) (10)
Use of an active center-directed plasmin inhibitor elucidates the multiplicity of plasmin actions. (1996) (9)
Synthesis of peptide chloromethyl ketones and examination of their inhibitory effects on human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE). (1987) (9)
Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein. (1989) (9)
Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines. (2000) (9)
Fibrinolytic Activity of Lung and Spleen Extracts Observed in Conventional but not in Germ-Free Rats (1979) (9)
Synthesis of stereoisomeric Suc-Tyr-Leu-Val-pNA and their properties as substrate and inhibitor for human spleen fibrinolytic proteinase (SFP). (1981) (9)
Variation in Activities of Non-Plasmin Fibrinolytic Proteinase and Plasminogen-Activator in the Lung and Spleen Induced by Bacterial Endotoxin in Rats with Special Reference to the Effects of MD-805 (1985) (9)
Highly selective synthetic inhibitors with regard to plasma-kallikrein activities. (1989) (8)
[Studies on a plasminogen activating system in human milk. I. Isolation of plasminogen activator and proactivator from human milk, and estimation of their molecular weights (author's transl)]. (1974) (8)
Human Spleen Insoluble Fibrinolytic Proteinase Acting at Neutral pH: Its Partial Purification and Characterization (1981) (7)
GEL FILTRATION OF FIBRINOLYTIC COMPONENTS OF BLOOD PLASMA IN MAN AND RABBIT. (1965) (7)
Distribution of plasminogen-activator in human milk samples collected at various days after delivery. (1980) (7)
Production of the modified form of human plasminogen in the plasma activated by urokinase. (1983) (6)
Development of selective inhibitors against plasma kallikrein. (1991) (5)
[Studies on the plasminogen activating system in human milk. VI. Differences in properties between milk activator and glandular kallikrein]. (1982) (4)
Enzymatic properties of human leukocyte elastase complexed to alpha 2-macroglobulin: increases in amidolytic and fibrinolytic activities on incubation. (1987) (4)
Enzymatic properties of milk activator in relation to synthetic chromogenic substrates. (1980) (4)
Purification method for human plasma kallikrein by a new affinity chromatography. (1998) (4)
New modified activated partial thromboplastin time and prothrombin time methods using a synthetic chromogenic substrate in combination with diazotization. (1987) (3)
A partially degraded form of human plasminogen in circulating blood. (2008) (3)
Recent studies of the synthetic selective inhibitors; With special reference to non-plasmin fibrinolytic enzyme, plasmin and plasma-kallikrein (1988) (3)
Amino acids and peptides. XXII. Synthesis of substrates and inhibitors of human leukocyte cathepsin G. (1988) (3)
Demonstration of two types of plasminogen activators in human milk by SDS-PAGE copolymerizing fibrinogen and plasminogen: different variations of the activators in pueriperium. (1987) (3)
A hematological approach to germfree rats: concentration of fibrinogen and antiplasmin. (1973) (2)
Inhibition of α-Chymotrypsin by Suc-L-Tyr-D-Leu-D-Phe-pNA, a Stereoisomer of a Specific Substrate (1985) (2)
Stereoisomeric alanine peptides as substrates for human spleen fibrinolytic proteinase (SFP). (1981) (2)
Newly synthesized -Val-pNA type substrate for spleen insoluble serine proteinase (1982) (2)
Recent studies of the synthetic selective inhibitors; with special reference to non-plasmin fibrinolytic enzyme, plasmin and plasma-kallikrein. (1988) (2)
New synthetic inhibitors of leucocyte elastase-like proteinase (ELP): Application to the purification method of ELP (1983) (2)
Plasminogen-free proactivator B obtained from human plasma. (1966) (2)
KCL-EXTRACTED PLASMINOGEN ACTIVATOR IN KIDNEY OF RABBITS. (1964) (2)
Clearance of modified plasminogen produced in the circulation after strenuous exercise. (1984) (2)
[ON THE DISAPPEARANCE OF THE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY IN KIDNEY PRODUCED BY MITOMYCIN C ADMINISTRATION TO RABBITS]. (1964) (2)
Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization. (2001) (2)
Okamoto's Strategy to Develop Argatroban: An Innovative Concept for the Future (2008) (2)
The concentrations of human leukocyte elastase and cathepsin G in plasma, serum and leukocytes (1989) (1)
Search for laboratory findings which well reflect elevation of leukocyte elastase in serum (1988) (1)
A Smaller Molecule SK-Reactive Protein (Plasminogen-Proactivator) Derived from the Macromolecule of Human Plasma Fraction I. (1975) (1)
Studies on the plasminogen activating system in human milk. V. Purification of the milk-activator and its properties. (1980) (1)
Design of plasma kallikrein selective inhibitor and its application to affinity chromatography (1999) (1)
The interesting variation of proactivator of plasminogen in an early infant. (1965) (1)
Synthesis of tripeptide amide derivatives and examination of their inhibitory effect on human leukocyte elastase (HLE). (1988) (1)
Existence of large Molecular Plasminogen Proactivator in Plasma from a Congenital Afibrinogenemia Patient (1971) (1)
New Synthetic Peptide Substrates Of -Val-pNA Type For An Insoluble Fibrinolytic Serine Enzyme Extracted From Human Spleen (1981) (1)
Enzymatic properties of human leukocyte cathepsin G and its complex with α2-macroglobulin (1987) (1)
Increase of nonplasmin fibrinolytic activity in the lung and spleen of streptozotocin-induced diabetic rats. (1987) (1)
SYNTHESIS OF PEPTIDE INHIBITORS OF HUMAN SPLEEN FIBRINOLYTIC PROTEINASE (SFP) AND HUMAN LEUKOCYTE ELASTASE-LIKE PROTEINASE (ELP) (1985) (1)
Production of Lys-plasminogen in urokinase-activated human plasma. (1986) (1)
Enzymatic properties of α2-macroglobulin-elastase complex (1985) (1)
[Studies of a plasminogen activating system in human milk: II. Some properties of milk plasminogen activator (author's transl)]. (1975) (0)
Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolysis System : Synthesis of Plasmin Inhibitor and Evaluation of Their Inhibitory Effect (1998) (0)
[Proceedings: Fibrinolysis activating factor in the human milk]. (1974) (0)
Multimolecular form of human plasminogen in individual subjects. (1984) (0)
Contents, Vol. 19, 1989 (1989) (0)
[The estimation method for plasminogen content using fibrin plate with urokinase (author's transl)]. (1976) (0)
Synthesis of peptide inhibitors of human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase‐like proteinase (ELP) (2009) (0)
[Proceedings: Isolation and purification of proactivator and plasminogen in the human blood]. (1974) (0)
[Proactivator-activator system in human plasma fibrinolysis: studies on the synthetic fibrinolytic system composed of functionally pure fibrinogen, plasminogen and proactivator, separated from human plasma]. (1972) (0)
The characteristics of stereogeometry at the active center of plasmin (1985) (0)
[Inhibitory effect of 4-(2-carboxyethyl) phenyl trans-4-aminomethyl cyclohexane carboxylate hydrochloride on fibrinolysis, esterolysis and proteolysis and its degradation by serum esterases: in vitro study]. (1973) (0)
[A NEW METHOD OF THE ANALYSIS OF EPSILON-AMINOCAPROIC ACID (EACA) AND AMINOMETHYLCYCLOHEXANE CARBOXYLIC ACID (AMCHA), THE POTENT ANTIFIBRINOLYTIC AGENTS]. (1964) (0)
Preparation of Highly Efficient Resin for Affinity Chromatography Employing Synthetic Specific Inhibitors : Further Studies on Purification of Plasma Kallikrein (PK) (2000) (0)
The level of granulocyte elastase (ELP) in children suffering from inflammatory diseases. (1985) (0)
Subject Index, Vol. 19, 1989 (1989) (0)
Streptokinase (SK) and Its Reactive Protein Separated from Human Plasma (1976) (0)
Development of Plasmin Inhibitors and Their Effect on M1(Melanoma) and HT29 Cell Lines (2000) (0)
Lower molecular weight species of alpha 2-macroglobulin-plasmin complexes in human plasma activated by urokinase. (1985) (0)
[Proceedings: 67. Separation of fibrinolytic agents in human blood by lysine-sepharose (author's transl)]. (1973) (0)
Production of the modified form of human plasminogen by alpha 2-macroglobulin-plasmin complexes. (1985) (0)
Enhancement of spleen plasminogenolytic activity with carrageenan-induced inflammation (1988) (0)
[A method for separation of plasminogen from bovine plasma fraction. I. With reference to some properties of the plasminogen]. (1971) (0)
[Studies on a plasminogen activating system in human milk: III. Formation mechanism of plasminogen activator by SK from the aspect of molecular weight (author's transl)]. (1976) (0)
Purification of Plasma Kallikrein (PK) : Preparation of PK Specific Inhibitor-Polymer Conjugate and Its Application to Purification of PK (1996) (0)
STUDIES ON THE URINARY FIBRINOLYTIC ACTIVITY IN NORMAL AND PATHOROGIC STATES (1959) (0)
[Releasing of plasminogen-activator from the kidney to the blood (author's transl)]. (1978) (0)
Variation of spleen fibrinolytic activity in pregnant and puerperal mice (1988) (0)
[Studies on a plasminogen activating system in human milk: V. Purification of milk-activator and its properties (author's transl)]. (1980) (0)
Thrombin in synovial fluids with osteoarthritis patients. (1992) (0)
A separation method of plasminogen from human plasma, and its activity measured by human fibrin agar plate (1976) (0)
Two types of plasminogen activators in human milk (1986) (0)
The assessing method for multimolecular forms of plasminogen in an individual human blood (1980) (0)
PROLONGED HYPERPLASMINEMIA WITH MITOMYCIN C IN RABBITS. REVERSIBLE DISAPPEARANCE OF TISSUE ACTIVATOR IN PARENCHYMA OF KIDNEY. (1964) (0)
Neutral proteinase activity extracted from human spleen (1980) (0)
Elastase activities in neutrophils and plasma of patients with leukemia (38 cases in CML and 10 cases in AML) (1986) (0)
[Activation system of fibrinolysis (author's transl)]. (1974) (0)
Inhibition of alpha-chymotrypsin by Suc-L-Tyr-D-Leu-D-Phe-pNA, a stereoisomer of a specific substrate. (1985) (0)
Fibrinolytic and amidolytic activities of elastase-and chymotrypsin-like proteases in spleen and leukocytes of some mammals. (1989) (0)
[Fluctuations in pulmonary fibrin decomposing activities (plasmin and non-plasmin activities) in an endotoxin DIC model in rats]. (1982) (0)
Characteristics of Human Milk Plasminogen Activator (Galactokinase) (1979) (0)

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