Vincent J. Cristofalo
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Vincent J. Cristofalobiology Degrees
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Cell Biology
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Neuroscience
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Biochemistry
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Biology
Why Is Vincent J. Cristofalo Influential?
(Suggest an Edit or Addition)Vincent J. Cristofalo's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. (1998) (535)
- Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells. (1973) (513)
- Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. (2000) (456)
- Characterization of a new human diploid cell strain, IMR-90. (1977) (339)
- Is beta-galactosidase staining a marker of senescence in vitro and in vivo? (2000) (331)
- Replicative senescence of human fibroblast-like cells in culture. (1993) (267)
- Replicative senescence: a critical review (2004) (248)
- Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. (2001) (248)
- Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts. (1986) (204)
- Ultrastructural changes accompanying the aging of human diploid cells in culture. (1972) (176)
- Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence (2001) (168)
- The effect of oxygen tension on the growth and metabolism of WI‐38 cells (1976) (151)
- Proliferative capacity and DNA content of aging human diploid cells in culture: A cytophotometric and autoradiographic analysis (1974) (143)
- Characterization of the cell cycle of cultured human diploid cells: Effects of aging and hydrocortisone (1977) (135)
- Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state. (1993) (130)
- Progressive loss of the proliferative response of senescing WI-38 cells to platelet-derived growth factor, epidermal growth factor, insulin, transferrin, and dexamethasone. (1984) (114)
- A standard procedure for cultivating human diploid fibroblastlike cells to study cellular aging (1980) (114)
- Cloning of the human twist gene: its expression is retained in adult mesodermally-derived tissues. (1997) (112)
- Age-dependent modifications of gene expression in human fibroblasts. (1998) (105)
- Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts (1983) (93)
- Metabolic Aspects of Aging in Diploid Human Cells (1970) (93)
- Reinitiation of cellular DNA synthesis in BrdU‐selected nondividing senescent WI‐38 cells by simian virus 40 infection (1985) (90)
- Lysosomal enzymes and aging in vitro: Subcellular enzyme distribution and effect of hydrocortisone on cell life-span (1975) (88)
- Cell size and nucleic acid content in the diploid human cell line WI-38 during aging. (1969) (87)
- The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro (1977) (87)
- Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI‐38) (1999) (85)
- [125I]EGF binding ability is stable throughout the replicative life‐span of WI‐38 cells (1983) (83)
- Alterations in the responsiveness of senescent cells to growth factors. (1989) (83)
- Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene. (1993) (77)
- Oxygen-sensitive stages of the cell cycle of human diploid cells (1978) (75)
- A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. (1998) (74)
- SA β Gal staining: Biomarker or delusion (2005) (72)
- Respiration and glycolysis in the human diploid cell strain wi‐38 (1966) (70)
- Studies on respiration and glycolysis in transplanted hepatic tumors of the rat. (1968) (69)
- Enzyme activity during the growth and aging of human cells in vitro (1967) (69)
- The influence of culture medium volume on cell density and lifespan of human diploid fibroblasts. (1975) (67)
- Histone acetylation during aging of human cells in culture. (1972) (66)
- Molecular markers of senescence in fibroblast-like cultures (1996) (65)
- Growth regulation of WI38 cells in s serum-free medium. (1981) (65)
- Significant correlation of species longevity with DNA double strand break recognition but not with telomere length (2009) (65)
- Expression of p21 is not required for senescence of human fibroblasts. (1996) (62)
- Cellular replicative capacity correlates primarily with species body mass not longevity (2005) (62)
- Insulin‐like growth factor‐I: Specific binding to high and low affinity sites and mitogenic action throughout the life span of WI‐38 cells (1987) (61)
- Cellular biomarkers of aging (1988) (61)
- Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast. (2001) (59)
- GLUCOSE UTILIZATION IN HOMOGENATES OF THE MORRIS HEPATOMA 5123 AND RELATED TUMORS. (1963) (58)
- Reduction in heat shock gene expression correlates with increased thermosensitivity in senescent human fibroblasts. (1992) (55)
- Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene. (1991) (55)
- Chromatin template activity during aging in WI38 cells. (1975) (53)
- Hydrocortisone effects on cell proliferation: specificity of response among various cell types. (1977) (53)
- Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling* (2006) (53)
- Thymidine triphosphate synthesis in senescent WI38 cells. Relationship to loss of replicative capacity. (1983) (52)
- Cellular Senescence in Vitro (1982) (50)
- Late induction of CREB/ATF binding and a concomitant increase in cAMP levels in T and B lymphocytes stimulated via the antigen receptor. (1996) (50)
- Inhibition of growth of HeLa and WI-38 cells by dehydroepiandrosterone and its reversal by ribo- and deoxyribonucleosides. (1986) (50)
- Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence (2002) (49)
- Aging in Cell and Tissue Culture (1970) (49)
- Proteasome inhibitors shorten replicative life span and induce a senescent‐like phenotype of human fibroblasts (2006) (49)
- Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts. (2003) (47)
- Putative role for EPC‐1/PEDF in the G0 growth arrest of human diploid fibroblasts (2003) (47)
- Changes in specific dexamethasone binding during aging in WI-38 cells. (1981) (47)
- Hydrocortisone: A specific modulator of in vitro cell proliferation and aging (1979) (46)
- IGF-1 receptor levels and the proliferation of young and senescent human fibroblasts. (1993) (45)
- The Pathway of Cell Senescence: WI-38 Cells Arrest in Late G1 and Are Unable to Traverse the Cell Cycle from a True G0 State (1998) (45)
- Loss of EPC-1/PEDF expression during skin aging in vivo. (2004) (45)
- SA beta Gal staining: biomarker or delusion. (2005) (44)
- Differential gene expression between young and senescent, quiescent WI-38 cells (1992) (44)
- Effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts. (1993) (43)
- Cell size in aging monolayer cultures (1977) (40)
- Growth factors as probes of cell aging (1989) (38)
- Growth and Glycolysis in the Human Diploid Cell Strain WI-38.∗ (1965) (38)
- EGF- and PDGF-stimulated phosphorylation in young and senescent WI-38 cells. (1991) (38)
- Thymidine labelling index as a criterion of aging in vitro. (1976) (37)
- Classification system based on the functional equivalency of mitogens that regulate WI-38 cell proliferation. (1988) (35)
- Regulation of Collagenase Expression during Replicative Senescence in Human Fibroblasts by Akt-Forkhead Signaling* (2002) (35)
- Identification of proteins differentially expressed in quiescent and proliferatively senescent fibroblast cultures. (1995) (35)
- Skin fibroblasts from aged Fischer 344 rats undergo similar changes in replicative life span but not immortalization with caloric restriction of donors. (1992) (34)
- Expression and regulation of superoxide dismutase activity in human skin fibroblasts from donors of different ages (1995) (33)
- Molecular biology of aging. (1994) (33)
- Error accumulation and aging in human diploid cells. (1974) (33)
- Analysis of the G1 arrest position of senescent WI38 cells by quinacrine dihydrochloride nuclear fluorescence. Evidence for a late G1 arrest. (1986) (31)
- Use of the fibroblast model in the study of cellular senescence. (2000) (31)
- Analysis of EPC‐1 growth state–dependent expression, specificity, and conservation of related sequences (1995) (30)
- Hydrocortisone as a modulator of cell division and population life span. (1975) (30)
- Effects of cellular aging on the induction of c-fos by antioxidant treatments (1996) (30)
- Overexpression of the two-chain form of cathepsin B in senescent WI-38 cells. (1992) (29)
- Cellular senescence: factors modulating cell proliferation in vitro. (1985) (29)
- Renewed DNA synthesis in senescent WI‐38 cells by expression of an inducible chimeric c‐fos construct (1992) (28)
- Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: Reduced AP‐1 activation and collagenase gene expression (1995) (28)
- The effect of hydrocortisone on DNA synthesis and cell division during aging in vitro. (1975) (28)
- Mitogen-independent phosphorylation of S6K1 and decreased ribosomal S6 phosphorylation in senescent human fibroblasts. (2000) (26)
- Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors (2002) (25)
- Regulation of EPC‐1/PEDF in normal human fibroblasts is posttranscriptional (2000) (25)
- Cell cycle-dependent regulation of Ca2+ in young and senescent WI-38 cells. (1993) (24)
- Expression and structure of human SPARC transcripts: SPARC mRNA is expressed by human cells involved in extracellular matrix production and some of these cells show an unusual expression pattern. (1990) (23)
- The effect of dexamethasone on epidermal growth factor binding and stimulation of proliferation in young and senescent WI38 cells. (1986) (22)
- Modulation of cell proliferation and senescence of WI-38 cells by hydrocortisone. (1979) (21)
- Dysdifferentiative nature of aging: passage number dependency of globin gene expression in normal human diploid cells grown in tissue culture. (1985) (21)
- Normal and neoplastic human cells have different histone H1 compositions. (1982) (20)
- 10 – HUMAN DIPLOID CELL CULTURES: THEIR USEFULNESS IN THE STUDY OF GENETIC VARIATIONS IN METABOLISM (1972) (20)
- Enhanced proliferation of human fibroblasts, in the presence of dexamethasone, is accompanied by changes in p21Waf1/Cip1/Sdi1 and the insulin‐like growth factor type 1 receptor (1998) (19)
- Cell Impairment in Aging and Development (2013) (18)
- Analysis of cell division by time‐lapse cinematographic studies of hydrocortisone‐treated embryonic lung fibroblasts (1984) (18)
- A procedure for the serum-free growth of normal human diploid fibroblasts (1980) (17)
- Ten years later: what have we learned about human aging from studies of cell cultures? (1996) (17)
- Changes in gene expression during senescence in culture (1992) (16)
- Modulation of WI‐38 cell proliferation by elevated levels of CaCl2 (1986) (16)
- A DNA chip off the aging block (2000) (16)
- A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts (1998) (16)
- CRC handbook of cell biology of aging (1985) (15)
- Pharmacological Intervention in the Aging Process (1978) (15)
- Enhanced proliferation of WI38 cells in the presence of glucocorticoid-conditioned medium. (1985) (14)
- Cell senescence: an evaluation of replicative senescence in culture as a model for cell aging in situ. (2003) (14)
- Human fetal lung fibroblasts: Observations on origin and stability in culture (1983) (14)
- Extension of replicative lifespan in WI-38 human fibroblasts by dexamethasone treatment is accompanied by suppression of p21 Waf1/Cip1/Sdi1 levels. (2003) (13)
- Abundance of α1(I) and α1(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal dermis (1997) (13)
- Trypsinization frequency and loss of proliferative capacity in WI-38 cells. (1979) (13)
- Glucocorticoid Modulation of Cell Proliferation (1981) (13)
- Alterations in contact and density-dependent arrest state in senescent WI-38 cells (1994) (12)
- Age-associated changes in glutamine synthetase activity in WI-38 cells (1978) (12)
- Effect of cell density and senescence of WI-38 cells on cytochemically demonstrable phosphatases (1979) (12)
- SOME PROPERTIES OF GLUCOKINASE IN NORMAL AND NEOPLASTIC LIVER. (1963) (12)
- Metabolism of rubella virus-infected BHK21 cells Enhanced glycolysis and late cellular inhibition (2005) (11)
- Scintillation fluid shortens exposure times in autoradiography. (1979) (11)
- Enzyme Activities of Some Cultured Human Cells.∗ (1967) (10)
- Oxygen sensitivity in the insect Prodenia eridania. (1960) (10)
- Cell culture aging: Insights for cell aging in vivo? (1999) (10)
- Some Effects of Oxygen on the Insects Anagasta kuehniella and Tenebrio molitor (1961) (9)
- Autocrine stimulation of WI38 cell proliferation in the presence of glucocorticoids. Characteristics of the stimulatory factor(s) involved in this response. (1987) (9)
- Aging and cellular defense mechanisms (1992) (8)
- Is increased arachidonic acid release a cause or a consequence of replicative senescence? (2001) (8)
- Hydrocortisone stimulation of DNA synthesis in bromodeoxyuridine-selected non-dividing WI-38 cells (1982) (8)
- Chlamydomonas: Colored Excretion Products (1962) (8)
- Culture of epithelial cells from the rat pleura (2007) (8)
- Altered Expression of theTwistGene in Young versus Senescent Human Diploid Fibroblasts (1996) (7)
- 8 – Glucocorticoid Enhancement of Cellular Proliferation in Vitro (1987) (7)
- Cell Aging: A Model System Approach (1978) (7)
- Stimulation of DNA synthesis in senescent human cells following incubation with plasma membranes. (1992) (7)
- Abundance of alpha 1(I) and alpha 1(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal dermis. (1997) (6)
- Hydrocortisone-dependent alterations of transcriptional activity in WI38 cells. (1979) (6)
- Senescent WI-38 fibroblasts overexpress LPC-1, a putative transmembrane shock protein. (1998) (6)
- Growth factors and cell aging. (1990) (6)
- Control of cell proliferation in senescent cells. (1992) (6)
- Lithium mimics dexamethasone in stimulating DNA synthesis by WI-38 cells. (1992) (6)
- Transition probability model and aging human diploid cell cultures: a reply to Smith (1977). (1978) (6)
- The 1983 Robert W. Kleemeier Award lecture. The destiny of cells: mechanisms and implications of senescence. (1985) (5)
- Atmospheric stability in cell culture vessels (1976) (5)
- Immortalization in a normal foreskin fibroblast culture following transduction of cyclin A2 or cdk1 genes in retroviral vectors. (2004) (5)
- Altered expression of the twist gene in young versus senescent human diploid fibroblasts. (1996) (5)
- Overview of biological mechanism of aging. (1990) (4)
- Spontaneous transformation of a cloned cell line of normal diploid bovine vascular endothelial cells (1984) (4)
- The growth of WI-38 cells in a serum-free, growth factor-free, medium with elevated calcium concentrations (1986) (4)
- LOSS OF RESPONSIVENESS TO GROWTH FACTORS IN CELL SENESCENCE (1984) (4)
- Defects in signal transduction during replicative senescence of diploid human fibroblasts in vitro. (1998) (4)
- On models and the study of senescence: reflections on the state of biogerontology and a farewell. (1991) (3)
- The energy status of aging cells in culture: the adenine nucleotide pool [proceedings]. (1978) (3)
- "I no longer believe that cell death is programmed. ..", an interview with Vincent Cristofalo. (2001) (2)
- CHAPTER 12 – Glucocorticoid Actions on Fibroblasts in Tissue Culture (1986) (2)
- Focus on modern topics in the biology of aging (2002) (2)
- Enzyme activity during the growth and aging of human cells. (1967) (2)
- Characterization of a new human diploid cell line—IMR-91 (1983) (2)
- REGULATION OF PROLIFERATIVE CAPACITY DURING AGING IN CELL CULTURE (1977) (2)
- Use of the Fibroblast Model (1998) (2)
- Special Focus on the Biology of Aging (1991) (2)
- On understanding the biology of aging: Studies in space (1991) (2)
- Perspectives in the Biology of Aging (1987) (1)
- Additional thoughts on free radicals and life span (1993) (1)
- Cell Culture as a Model (2011) (1)
- Explorations in Aging (2012) (1)
- Processing Cells for Enzyme Assays (1973) (1)
- Cellular senescence: cell proliferation and its control. (1980) (1)
- Momentum in the Biology of Senescence: Renaissance or Illusion? (1991) (1)
- Cell culture as a model for gerontological research. (1997) (1)
- Hydrocortisone is associated with cell surface blebbing in cultures of human embryonic lung fibroblasts (1986) (1)
- Overview of Biological Mechanism of Aging (1990) (0)
- Program schedule (2022) (0)
- Journal of the American Aging Association (2002) (0)
- Recent articles in ageing research. (1973) (0)
- Thymidine metabolism in human cells during aging in vitro [proceedings]. (1978) (0)
- Book Review:Variation, Senescence, and Neoplasia in Cultured Somatic Cells. John W. Littlefield (1977) (0)
- Obituary. Jay Roberts, PhD (1927–2002) (2003) (0)
- Impaired synergism of dexamethasone and IGF-I in cultures of aged fibroblasts. (1988) (0)
- A model system approach to the biology of aging. (1976) (0)
- Oxidation of Cholesterol by Rat Liver Mitochondria: Influence of Ethyl α -p-Chlorophenoxyisobutyrate (1969) (0)
- The Philadelphia Symposium on Aging (1975) (0)
- THE COMPARATIVE METABOLISM OF A NORMAL AND A PARALYZED MUTANT STRAIN OF CHLAMYDOMONAS (1962) (0)
- Effect of dehydroepiandrosterone on the proliferation and replicative life span of wi 38 cells and its cytotoxic effect on hela tcrc 2 cells (1984) (0)
- Dave Kritchevsky On the occasion of his sixtieth birthday (1980) (0)
- Preface (1990) (0)
- Impaired synergism of dexamethasone and IGF-I in cultures of aged fibroblasts. (1988) (0)
- Lankenau Medical Research Center (2000) (0)
- Cellular Aging (2001) (0)
- Overview of cellular senescence (2000) (0)
- Biological Gerontology (1977) (0)
- 5. Differential gene expression during senescence in culture (1992) (0)
- Biochemical Studies on Aging Diploid Cells1 (1969) (0)
- Control of cell proliferation in senescent cells. (1992) (0)
- Contents, Vol. 19, 1969 (1969) (0)
- The regulation of gene expression in cell cultures: What can we learn from cell cultures about the mechanisms of human senescence (1995) (0)
- Program schedule (2022) (0)
- Contents, Vol. 31, 1985 (1985) (0)
- Preface (2001) (0)
- Pharmacological intervention in the aging process : [proceedings] (1978) (0)
- Gordon Conference Satellite — Intervention in Aging IV: “Consequences of age changes explored at the cellular and subcellular levels on organismic function” (1995) (0)
- Senescence in Cell Culture: An Accumulation of Errors or Terminal Differentiation? (1977) (0)
- The Regulation of Cell Senescence (2020) (0)
- THE REGULATION OF WI-38 CELL PROLIFERATION BY EGF AND PDGF IN SERUM-FREE MEDIUM (1981) (0)
- Samuel Goldstein (1938-1994) (1994) (0)
- Effects of tumor necrosis factor and interferon-β on proliferation and epidermal growth factor binding in young and senescent WI-38 cells (1993) (0)
- Growth Factors and Cell Aging (1990) (0)
- Program schedule (2007) (0)
- Altered endocrine status during aging : proceedings of the Fourth Philadelphia Symposium on Aging, Philadelphia, Pennsylvania, April 7-8, 1983 (1984) (0)
- Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation (2001) (0)
- THE EFFECT OF O X Y G E N A N D VITAMIN E ON THE LIFESPAN OF H U M A N DIPLOID CELLS IN VITRO (2003) (0)
- Abstracts from Twenty-Fifth Annual Meeting (2007) (0)
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