Vadivel Ganapathy

Vadivel Ganapathy's AcademicInfluence.com Rankings

Vadivel Ganapathy

Computer Science

#3881

World Rank

#4078

Historical Rank

Computational Linguistics

#274

World Rank

#278

Historical Rank

Machine Learning

#593

World Rank

#600

Historical Rank

Artificial Intelligence

#793

World Rank

#805

Historical Rank

computer-science Degrees

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Computer Science

Vadivel Ganapathy's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Vadivel Ganapathy's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. (2014) (1417)
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. (1993) (871)
Expression cloning of a mammalian proton-coupled oligopeptide transporter (1994) (856)
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. (2009) (644)
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. (2013) (597)
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. (2009) (527)
Human Intestinal H+/Peptide Cotransporter (1995) (455)
Cloning and Functional Characterization of a Potential-sensitive, Polyspecific Organic Cation Transporter (OCT3) Most Abundantly Expressed in Placenta* (1998) (442)
Death of retinal neurons in streptozotocin-induced diabetic mice. (2004) (434)
Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1). (1996) (400)
Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake2) and Evidence for the Expression of the Transporter in the Brain* (1998) (390)
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. (1998) (363)
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. (1999) (339)
Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet (2006) (323)
Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs. (2015) (311)
Peptide transporters in the intestine and the kidney. (1996) (309)
Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. (1998) (293)
Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. (2000) (286)
Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2 (*) (1995) (278)
Cloning of the Sodium-dependent, Broad-scope, Neutral Amino Acid Transporter Bo from a Human Placental Choriocarcinoma Cell Line* (1996) (265)
Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (1995) (261)
Cloning and Functional Characterization of a σ Receptor from Rat Brain (1998) (260)
Functional Identification of SLC5A8, a Tumor Suppressor Down-regulated in Colon Cancer, as a Na+-coupled Transporter for Short-chain Fatty Acids* (2004) (251)
Cloning of an Amino Acid Transporter with Functional Characteristics and Tissue Expression Pattern Identical to That of System A* (2000) (245)
Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. (1999) (228)
Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. (2012) (224)
Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. (1983) (219)
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. (2013) (212)
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. (2000) (208)
Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer (2008) (205)
Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. (1994) (205)
Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases (2010) (203)
Glutamine transporters in mammalian cells and their functions in physiology and cancer. (2016) (200)
Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. (1997) (199)
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis (2015) (196)
Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development (2009) (195)
Initial conditions of serotonin transporter kinetics and genotype: influence on ssri treatment trial outcome (2002) (193)
Cloning of the Human Thiamine Transporter, a Member of the Folate Transporter Family* (1999) (181)
Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. (2001) (177)
β-Lactam Antibiotics as Substrates for OCTN2, an Organic Cation/Carnitine Transporter* (2000) (174)
Molecular cloning of the human placental folate transporter. (1995) (172)
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. (2006) (171)
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (2000) (168)
SLC19: the folate/thiamine transporter family (2004) (161)
Exon‐Intron Structure, Analysis of Promoter Region, and Chromosomal Localization of the Human Type 1 σ Receptor Gene (1998) (160)
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. (1999) (159)
Regulation of the human serotonin transporter by interleukin-1 beta. (1995) (158)
Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis. (2010) (157)
Mechanisms of the Human Intestinal H-coupled Oligopeptide Transporter hPEPT1 (*) (1996) (155)
Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency. (1999) (152)
Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. (2001) (149)
SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer* (2011) (148)
Cloning and Functional Expression of a cDNA Encoding a Mammalian Sodium-dependent Vitamin Transporter Mediating the Uptake of Pantothenate, Biotin, and Lipoate* (1998) (147)
Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate* (2004) (145)
Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. (1999) (145)
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. (2009) (145)
Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium* (2000) (144)
Human Placental Na+-dependent Multivitamin Transporter (1999) (143)
Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. (1989) (143)
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). (1991) (143)
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line. (1994) (141)
SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. (2006) (141)
Placental transporters relevant to drug distribution across the maternal-fetal interface. (2000) (141)
Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. (2000) (140)
Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2 (2003) (140)
Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. (2000) (139)
Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery (2004) (138)
Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines. (2003) (133)
Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types (2018) (133)
Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2. (1997) (129)
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. (2011) (128)
Nutrient transport pathways across the epithelium of the placenta. (1992) (126)
Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis. (2017) (125)
Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit. (1981) (125)
Citrate transport and metabolism in mammalian cells (2009) (123)
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. (2005) (121)
Colonic Gene Expression in Conventional and Germ-Free Mice with a Focus on the Butyrate Receptor GPR109A and the Butyrate Transporter SLC5A8 (2010) (121)
Identity of SMCT1 (SLC5A8) as a neuron‐specific Na+‐coupled transporter for active uptake of l‐lactate and ketone bodies in the brain (2006) (120)
Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. (1999) (120)
Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. (2001) (119)
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon. (2019) (118)
H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. (2004) (118)
Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles. (1984) (117)
Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. (2001) (116)
Structure, Function, and Expression Pattern of a Novel Sodium-coupled Citrate Transporter (NaCT) Cloned from Mammalian Brain* (2002) (115)
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (1993) (114)
In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. (2008) (113)
Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). (2005) (113)
Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (2001) (111)
NF-κB Directly Regulates Fas Transcription to Modulate Fas-mediated Apoptosis and Tumor Suppression* (2012) (110)
Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. (2008) (110)
Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. (1992) (110)
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth. (2016) (109)
Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. (2002) (108)
Primary Structure, Genomic Organization, and Functional and Electrogenic Characteristics of Human System N 1, a Na+- and H+-coupled Glutamine Transporter* (2000) (108)
Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. (2015) (106)
Cloning and functional characterization of a new subtype of the amino acid transport system N. (2001) (105)
cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. (2000) (105)
Expression of the cystine-glutamate exchanger (xc−) in retinal ganglion cells and regulation by nitric oxide and oxidative stress (2006) (104)
Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts. (2003) (104)
Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. (2000) (104)
Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. (1999) (104)
Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. (2001) (103)
Cloning and functional characterization of a sigma receptor from rat brain. (1998) (103)
Transport of Nicotinate and Structurally Related Compounds by Human SMCT1 (SLC5A8) and Its Relevance to Drug Transport in the Mammalian Intestinal Tract (2007) (102)
Primary Structure and Functional Characteristics of a Mammalian Sodium-coupled High Affinity Dicarboxylate Transporter* (1999) (102)
Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta. (2000) (102)
The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. (2014) (100)
Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. (1994) (100)
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. (1998) (99)
Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains. (1990) (98)
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment (2020) (97)
Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer (2016) (96)
Mutations in Novel Organic Cation Transporter (OCTN2), an Organic Cation/Carnitine Transporter, with Differential Effects on the Organic Cation Transport Function and the Carnitine Transport Function* (1999) (96)
Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. (2006) (95)
Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl−-dependent TauT (SLC6A6) (2008) (95)
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. (2015) (95)
Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter B0. (1997) (95)
Cloning and functional characterization of a Na(+)-independent, broad-specific neutral amino acid transporter from mammalian intestine. (2000) (94)
The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression (2001) (94)
Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon. (2002) (94)
Biological functions of SLC5A8, a candidate tumour suppressor. (2005) (91)
Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. (2007) (90)
GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. (2012) (90)
Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. (1998) (88)
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. (1991) (88)
Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. (2008) (87)
Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. (2007) (86)
Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. (2004) (86)
Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer (2008) (86)
Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor. (2001) (84)
Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. (1997) (82)
Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. (2007) (80)
Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. (2005) (80)
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. (2010) (80)
Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization. (1995) (78)
Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. (2001) (78)
Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. (2000) (77)
GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis (2018) (77)
Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates. (2004) (76)
Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate (2011) (76)
c/ebpδ Null Mouse as a Model for the Double Knock-out of slc5a8 and slc5a12 in Kidney* (2006) (76)
Molecular and structural features of the proton-coupled oligopeptide transporter superfamily. (1998) (76)
PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4 (2010) (75)
Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium (2009) (74)
Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. (2011) (74)
SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. (2016) (72)
Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. (2007) (71)
The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. (2004) (70)
Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence (2014) (70)
Kidney proximal tubular epithelial-specific overexpression of netrin-1 suppresses inflammation and albuminuria through suppression of COX-2-mediated PGE2 production in streptozotocin-induced diabetic mice. (2012) (70)
Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta. (2007) (70)
Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc− in mouse retinal Müller glial cells (2009) (70)
The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy (2014) (70)
Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. (2015) (69)
Functional and molecular identification of sodium‐coupled dicarboxylate transporters in rat primary cultured cerebrocortical astrocytes and neurons (2006) (69)
Na+-H+ exchanger of human placental brush-border membrane: identification and characterization. (1986) (69)
Cloning and Expression of a b0,+-like Amino Acid Transporter Functioning as a Heterodimer with 4F2hc Instead of rBAT (1999) (69)
L-Carnitine-conjugated nanoparticles to promote permeation across blood–brain barrier and to target glioma cells for drug delivery via the novel organic cation/carnitine transporter OCTN2 (2017) (68)
Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production. (2000) (68)
The amino acid transport system y+L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen. (1995) (68)
Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein. (2001) (68)
Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cells. (2004) (68)
Characterization of tryptophan transport in human placental brush-border membrane vesicles. (1986) (67)
Role of transporters in placental transfer of drugs. (2005) (67)
An anti-tumor role for cGMP-dependent protein kinase. (2006) (67)
Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta. (1999) (67)
Vitamin C transport in human lens epithelial cells: evidence for the presence of SVCT2. (2001) (67)
Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). (2001) (67)
A high‐affinity, tryptophan‐selective amino acid transport system in human macrophages (2006) (67)
Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. (2006) (66)
Human placental monoamine transporters as targets for amphetamines. (1995) (66)
Structural and Functional Characteristics of Two Sodium-coupled Dicarboxylate Transporters (ceNaDC1 and ceNaDC2) fromCaenorhabditis elegans and Their Relevance to Life Span* (2003) (65)
Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+). (2001) (65)
Identification of a Na+-dependent cationic and neutral amino acid transporter, B(0,+), in human and rabbit cornea. (2004) (65)
Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. (2003) (65)
Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C. (1993) (64)
Na+ + Cl−‐gradient‐driven, high‐affinity, uphill transport of taurine in human placental brush‐border membrane vesicles (1988) (64)
Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress, and induces caspase-dependent cell death in antiestrogen–sensitive and resistant ER+ breast cancer cells (2010) (64)
Localization of peptide transporter in nuclei and lysosomes of the pancreas (1997) (63)
Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. (2007) (63)
Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (1994) (62)
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. (2006) (61)
Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). (2007) (61)
Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. (2007) (59)
Differential Influence of the 4F2 Heavy Chain and the Protein Related to b0,+ Amino Acid Transport on Substrate Affinity of the Heteromeric b0,+ Amino Acid Transporter* (2000) (59)
Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3‐bromopyruvate (2009) (58)
Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates. (2002) (58)
Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB0,+ to deliver chemotherapeutic agents for colon cancer therapy (2017) (58)
Peptide transport in intestinal and renal brush border membrane vesicles. (1982) (57)
Carrier-mediated reabsorption of small peptides in renal proximal tubule. (1986) (56)
Transport systems for opioid peptides in mammalian tissues (2005) (56)
Cyclic AMP-independent Up-regulation of the Human Serotonin Transporter by Staurosporine in Choriocarcinoma Cells (*) (1995) (56)
Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells. (2001) (56)
Expression of the extraneuronal monoamine transporter in RPE and neural retina (2000) (56)
Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart (2003) (56)
Depressed Patients Have Higher Body Temperature: 5-HT Transporter Long Promoter Region Effects (2003) (55)
Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. (2009) (55)
IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression (2007) (55)
Identification of insulin receptors on the mucosal surface of colon epithelial cells. (1985) (55)
Transport of Amino Acid Esters and the Amino-Acid-Based Prodrug Valganciclovir by the Amino Acid Transporter ATB0,+ (2004) (54)
Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health (2017) (54)
Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells. (1996) (54)
The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties. (1996) (54)
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP. (1996) (53)
Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo. (2018) (53)
A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles. (1988) (53)
Functional Expression of the Serotonin Transporter in Immortalized Rat Brain Microvessel Endothelial Cells (2000) (53)
Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras. (1998) (53)
Identification of histidyl and thiol groups at the active site of rabbit renal dipeptide transporter. (1986) (52)
Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1). (2011) (52)
Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. (2005) (52)
Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury. (2013) (52)
Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. (1995) (52)
Functional and molecular analysis of D-serine transport in retinal Müller cells. (2007) (51)
Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain. (2015) (51)
Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer. (2017) (51)
Isoforms, Expression, Glycosylation, and Tissue Distribution of CTL2/SLC44A2 (2010) (51)
Multiple transport systems for organic cations in renal brush-border membrane vesicles. (1989) (51)
Proton-coupled solute transport in the animal cell plasma membrane. (1991) (51)
Drugs of abuse and human placenta. (2011) (51)
Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy (2017) (50)
Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice. (2002) (50)
Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes* (2006) (50)
Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. (2013) (50)
Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1 (2012) (50)
Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. (1993) (50)
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (1997) (49)
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. (1994) (49)
Transport of guanidine in rabbit intestinal brush-border membrane vesicles. (1988) (49)
Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide (2001) (49)
Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression. (1998) (49)
Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine (2010) (48)
Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. (2010) (48)
Molecular identity and calmodulin-mediated regulation of the taurine transporter in a human retinal pigment epithelial cell line. (1994) (48)
Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. (2005) (48)
Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain. (1998) (48)
Heterologous expression of Pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl- pump activity. (2007) (48)
Sodium-dependent homo- and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATB degree. (1998) (47)
Electrophysiological Characterization and Modeling of the Structure Activity Relationship of the Human Concentrative Nucleoside Transporter 3 (hCNT3) (2006) (47)
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). (1995) (47)
The gamma-aminobutyric acid transporter and its interaction with taurine in the apical membrane of the bovine retinal pigment epithelium. (1992) (47)
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina (2014) (46)
Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. (2007) (46)
ς Receptor Ligand-Induced Up-Regulation of the H+/Peptide Transporter PEPT1 in the Human Intestinal Cell Line Caco-2 (1999) (46)
Serine racemase expression and d‐serine content are developmentally regulated in neuronal ganglion cells of the retina (2008) (46)
Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. (2011) (45)
Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. (2004) (45)
Transport of amino acid aryl amides by the intestinal H+/peptide cotransport system, PEPT1. (1998) (45)
Expression and function of iron‐regulatory proteins in retina (2010) (45)
Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina. (1999) (44)
H(+)-peptide cotransport in Madin-Darby canine kidney cells: expression and calmodulin-dependent regulation. (1995) (44)
The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane. (1990) (44)
An Ambidextrous Approach to Disrupt Redox Balance in Tumor Cell with Increased ROS Production and Decreased GSH Synthesis for Cancer Therapy. (2019) (44)
Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2). (1997) (44)
The blood–brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters (2009) (43)
Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation (2018) (43)
The Na+/Cl−-Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis (2017) (43)
Cotransporting Ion is a Trigger for Cellular Endocytosis of Transporter‐Targeting Nanoparticles: A Case Study of High‐Efficiency SLC22A5 (OCTN2)‐Mediated Carnitine‐Conjugated Nanoparticles for Oral Delivery of Therapeutic Drugs (2017) (43)
The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function. (2013) (42)
Characterization of N5-methyltetrahydrofolate uptake in cultured human retinal pigment epithelial cells. (1997) (42)
Partial purification and characterization of the human placental serotonin transporter. (1993) (42)
Transport characteristics of N‐acetyl‐l‐aspartate in rat astrocytes: involvement of sodium‐coupled high‐affinity carboxylate transporter NaC3/NaDC3‐mediated transport system (2005) (42)
Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H+/peptide transporter PEPT2 (2004) (42)
Interaction of Ibuprofen and Other Structurally Related NSAIDs with the Sodium-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8) (2006) (42)
Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium. (2006) (41)
Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia. (2014) (41)
Active transport of dopamine in human placental brush-border membrane vesicles. (1992) (41)
Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter. (1993) (41)
Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization. (1995) (41)
Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression (2018) (41)
Active transport of taurine in rabbit jejunal brush-border membrane vesicles. (1989) (40)
Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. (1992) (40)
Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta. (1988) (40)
Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa. (2012) (39)
A Na+/Cl–-coupled GABA Transporter, GAT-1, from Caenorhabditis elegans (2005) (39)
Transport and metabolism of monoamines in the human placenta (1993) (39)
Fatty acid-induced alterations in transport systems of the small intestinal brush-border membrane. (1988) (39)
Inhibition of Amino Acid Transport System A by Interleukin-1β in Trophoblasts (2005) (39)
Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2. (2003) (38)
Transcellular transfer of folate across the retinal pigment epithelium (2002) (38)
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter. (2010) (38)
Structure and function of mammalian sodium-dependent multivitamin transporter. (2000) (38)
High-affinity paroxetine binding to the human placental serotonin transporter. (1990) (38)
Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid. (2014) (38)
Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans (2013) (38)
Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood–brain barrier (2003) (37)
Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. (2010) (37)
H+ gradient-driven dipeptide reabsorption in proximal tubule of rat kidney. Studies in vivo and in vitro. (1987) (37)
A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles. (1988) (37)
Sodium-dependent carnitine transport in human placental choriocarcinoma cells. (1996) (37)
Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2) (2005) (37)
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse. (2004) (37)
Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation (2009) (36)
Expression of cyclic guanosine monophosphate‐dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis (2008) (36)
A Novel H+-coupled Oligopeptide Transporter (OPT3) from Caenorhabditis elegans with a Predominant Function as a H+ Channel and an Exclusive Expression in Neurons* (2000) (36)
Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta. (1985) (35)
Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice. (2002) (35)
Constitutive expression of the taurine transporter in a human colon carcinoma cell line. (1992) (35)
Interferon-γ induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells. (2015) (35)
Modulation of serotonin uptake kinetics by ions and ion gradients in human placental brush-border membrane vesicles. (1990) (35)
Human placenta: a direct target for cocaine action. (1994) (35)
Protein Digestion and Absorption (2012) (35)
Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis. (2013) (34)
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line. (1992) (34)
Peptide transport in rabbit intestinal brush-border membrane vesicles studied with a potential-sensitive dye. (1985) (33)
IFNγ Induces DNA Methylation–Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer (2015) (33)
Transporter occluded-state conformation-induced endocytosis: Amino acid transporter ATB0,+-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy. (2016) (33)
Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A (2001) (33)
Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells. (2005) (33)
Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans. (1999) (32)
Growth factors regulation of rabbit sodium-dependent neutral amino acid transporter ATB0 and oligopeptide transporter 1 mRNAs expression after enteretomy. (2001) (32)
Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells (2010) (32)
Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter. (1994) (32)
Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia. (2013) (32)
A Novel Pineal-specific Product of the Oligopeptide Transporter PepT1 Gene (2005) (31)
Interaction of kyotorphin and brain peptide transporter in synaptosomes prepared from rat cerebellum: implication of high affinity type H+/peptide transporter PEPT2 mediated transport system (1999) (31)
Tyrosine residues are essential for the activity of the human placental taurine transporter. (1989) (31)
Iron-mediated retinal degeneration in haemojuvelin-knockout mice. (2012) (31)
Relationship between thyroid hormone transport and neutral amino acid transport in JAR human choriocarcinoma cells. (1994) (30)
Peptide transport in rabbit kidney. Studies with L-carnosine. (1982) (30)
Properties of taurine transport in a human retinal pigment epithelial cell line. (1993) (30)
Difference between pharmacokinetics of mycophenolic acid (MPA) in rats and that in humans is caused by different affinities of MRP2 to a glucuronized form. (2007) (30)
IFN-γ Upregulates Survivin and Ifi202 Expression to Induce Survival and Proliferation of Tumor-Specific T Cells (2010) (30)
Selective Impairment of Taurine Transport by Cyclosporin A in a Human Placental Cell Line (1992) (29)
Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium. (2006) (29)
Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response (2012) (29)
Proton gradient-coupled uphill transport of glycylsarcosine in rabbit renal brush-border membrane vesicles. (1985) (29)
Molecular Mechanism of SLC5A8 Inactivation in Breast Cancer (2013) (29)
Antidepressant effects on kinase gene expression patterns in rat brain (2002) (29)
Specific interaction of 5-(N-methyl-N-isobutyl)amiloride with the organic cation-proton antiporter in human placental brush-border membrane vesicles. Transport and binding. (1992) (29)
Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells. (1999) (29)
Expression and regulation of the taurine transporter in cultured cell lines of human origin. (1994) (28)
Evidence for a dipeptide transport system in renal brush border membranes from rabbit. (1981) (28)
Chapter 10 Intestinal transport of peptides and amino acids (2000) (28)
Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina. (2014) (28)
Recent advances in drug delivery via the organic cation/carnitine transporter 2 (OCTN2/SLC22A5) (2018) (27)
Human solute carrier SLC6A14 is the β-alanine carrier (2008) (27)
Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. (2003) (27)
Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles. (1980) (26)
Carnitine Content and Expression of Mitochondrial β-Oxidation Enzymes in Placentas of Wild-Type (OCTN2+/+) and OCTN2 Null (OCTN2−/−) Mice (2004) (26)
Reconstitution of the human placental 5-hydroxytryptamine transporter in a catalytically active form after detergent solubilization. (1992) (26)
Uphill transport of beta-alanine in intestinal brush-border membrane vesicles. (1990) (26)
Interaction of fluoxetine with the human placental serotonin transporter. (1990) (26)
Norchloro-fluoro-homoepibatidine (NCFHEB) — A promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET (2008) (26)
Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes (1996) (26)
CHAPTER 65 – Protein Digestion and Absorption (2006) (25)
Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. (2008) (25)
Electrophysiological Characterization of the Polyspecific Organic Cation Transporter Plasma Membrane Monoamine Transporter (2012) (25)
Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. (1999) (25)
Polarized distribution of interleukin-1 receptors and their role in regulation of serotonin transporter in placenta. (2000) (25)
Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. (2011) (24)
Evidence for tripeptide-proton symport in renal brush border membrane vesicles. Studies in a novel rat strain with a genetic absence of dipeptidyl peptidase IV. (1990) (24)
Taurine uptake in apical membrane vesicles from the bovine retinal pigment epithelium. (1991) (24)
Sodium-gradient-driven, high-affinity, uphill transport of succinate in human placental brush-border membrane vesicles. (1988) (24)
Cyclic AMP-dependent up-regulation of the taurine transporter in a human retinal pigment epithelial cell line. (1995) (24)
Cellular uptake of amino acids: Systems and regulation (2003) (24)
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine (2016) (23)
Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis (2019) (23)
Protons and regulation of biological functions. (1991) (23)
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR. (1997) (23)
Species-Specific Influence of Lithium on the Activity of SLC13A5 (NaCT): Lithium-Induced Activation Is Specific for the Transporter in Primates (2015) (23)
SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling (2020) (23)
Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2) (2011) (23)
Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer. (2007) (23)
Functional expression of the intestinal peptide-proton co-transporter in Xenopus laevis oocytes. (1991) (23)
Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model (2017) (23)
Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health. (2013) (23)
Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia. (2015) (23)
Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection. (2009) (22)
Molecular characterization and expression pattern of taurine transporter in zebrafish during embryogenesis. (2008) (22)
Human Serotonin Transporter: Regulation by the Neuroprotective Agent Aurintricarboxylic Acid and by Epidermal Growth Factor (1997) (22)
Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter. (1999) (22)
Nicotinic Acid Inhibits Glucose-Stimulated Insulin Secretion Via the G Protein-Coupled Receptor PUMA-G in Murine Islet &bgr; Cells (2011) (22)
A Comparison of Caveolae and Caveolin-1 to Folate Receptor α in Retina and Retinal Pigment Epithelium (2001) (22)
Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1. (2008) (22)
Protein Digestion and Assimilation (2009) (21)
Interaction of clonidine with human placental Na+ -H+ exchanger. (1986) (21)
National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development. (2004) (20)
SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer (2021) (20)
Extracellular Citrate Fuels Cancer Cell Metabolism and Growth (2020) (20)
Receptors for IGF-I, but not for IGF-II, on proximal colon epithelial cell apical membranes. (1989) (20)
Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host (2017) (20)
pH-dependent fluoride transport in intestinal brush border membrane vesicles. (1998) (19)
Effect of papain treatment on dipeptide transport into rabbit intestinal brush border vesicles. (1981) (19)
Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells. (2013) (19)
Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter. (2008) (19)
Driving force for peptide transport in mammalian intestine and kidney. (1987) (19)
Peptide transporters. (1996) (19)
Kinetic evidence for a common transporter for glycylsarcosine and phenylalanylprolylalanine in renal brush-border membrane vesicles. (1990) (19)
Cystathionine Beta Synthase Expression in Mouse Retina (2013) (18)
Therapeutic application and construction of bilirubin incorporated nanoparticles. (2020) (18)
Evidence for active dipeptide transport in isolated proximal straight tubules. (1988) (18)
Preferred transport of O-(2-[18F]fluoroethyl)-d-tyrosine (d-FET) into the porcine brain (2007) (18)
Characterization of an ATP-driven H+ pump in human placental brush-border membrane vesicles. (1992) (17)
Inhibition of human placental Na+-H+ exchanger by cimetidine. (1986) (17)
Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells. (2013) (17)
Evidence for histidyl and carboxy groups at the active site of the human placental Na+-H+ exchanger. (1987) (17)
Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. (2017) (17)
Endocytosis of ATB0,+(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer (2020) (17)
Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines. (1995) (17)
Distribution and properties of the glycylsarcosine-transport system in rabbit renal proximal tubule. Studies with isolated brush-border-membrane vesicles. (1988) (17)
Evidence for two different broad-specificity oligopeptide transporters in intestinal cell line Caco-2 and colonic cell line CCD841. (2011) (17)
Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells (2015) (17)
Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer (2019) (17)
Role of dipeptidyl peptidase IV in uptake of peptide nitrogen from beta-casomorphin in rabbit renal BBMV. (1987) (17)
Preferential recognition of zwitterionic dipeptides as transportable substrates by the high-affinity peptide transporter PEPT2. (1999) (17)
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line (1998) (16)
Relative sensitivity to inhibition by cimetidine and clonidine differentiates between the two types of Na(+)-H+ exchangers in cultured cells. (1991) (16)
Inactivation of the human placental serotonin transporter by tyrosyl group-specific reagents. (1989) (16)
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin (2020) (16)
Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. (1994) (16)
Inhibition of rat and human prolidases by captopril. (1985) (16)
Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells. (2003) (16)
Involvement of thiol groups in the function of the dipeptide/proton cotransport system in rabbit renal brush-border membrane vesicles. (1989) (16)
Serine Racemase and D-Serine Transport in Human Placenta and Evidence for a Transplacental Gradient for D-Serine in Humans (2004) (15)
Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles (2005) (15)
Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease. (2016) (15)
Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis. (2014) (15)
Rapid Report (2001) (15)
Interaction of proline, 5-oxoproline, and pipecolic acid for renal transport in the rabbit. (1983) (15)
L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium (2014) (15)
Solubilization and functional reconstitution of the human placental taurine transporter. (1993) (15)
Functional link between tyrosine phosphorylation and human serotonin transporter gene expression. (1997) (15)
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells. (2011) (15)
Inhibition of system A amino acid transport activity by ethanol in BeWo choriocarcinoma cells. (2002) (15)
OCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo (2020) (15)
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. (2010) (15)
Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier. (2011) (15)
An essential role for vicinal dithiol groups in the catalytic activity of the human placental Na(+)-H+ exchanger. (1990) (15)
Inactivation of taurine transporter by calcium in purified human placental brush border membrane vesicles. (1991) (14)
Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery (2020) (14)
Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis (2016) (14)
The ATP-binding site of the human placental H+ pump contains essential tyrosyl residues. (1990) (14)
Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth. (2013) (13)
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. (2008) (13)
Regulation of proton‐coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate (2012) (13)
Transport and utilization of methionine sulfoxide in the rabbit. (1982) (13)
Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery (2016) (13)
Functional Distinction between Human and Mouse Sodium-Coupled Citrate Transporters and Its Biologic Significance: An Attempt for Structural Basis Using a Homology Modeling Approach. (2020) (12)
Peptidases and peptide transport in mammalian kidney. (1984) (12)
RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal (2020) (12)
Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice (2020) (12)
Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload. (2019) (12)
Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE (2009) (12)
Calcium-induced inhibition of taurine transport in brush-border membrane vesicles from rabbit small intestine. (1990) (12)
Human placenta as a target organ for cocaine action: Interaction of cocaine with the placental serotonin transporter (1994) (12)
Inhibition of brush-border membrane Na+-H+ exchanger by loperamide. (1987) (12)
Electrogenic nature of rat sodium-dependent multivitamin transport. (2000) (11)
Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR). (1994) (11)
Differential Modulation of Sodium- and Chloride-Dependent Opioid Peptide Transport System by Small Nonopioid Peptides and Free Amino Acids (2007) (11)
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier (2021) (11)
Cloning and Expression of a b 0 , 1-like Amino Acid Transporter Functioning as a Heterodimer with 4 F 2 hc Instead of rBAT (1999) (11)
Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu (2019) (11)
Evidence for tripeptide/H+ co-transport in rabbit renal brush-border membrane vesicles. (1990) (11)
Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) (2020) (11)
SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma (2012) (11)
Ratio of miR-196 s to HOXC 8 mRNA Correlates with Breast Cancer Cell Migration and Metastasis (2010) (10)
Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness (2017) (10)
Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. (2011) (10)
Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. (2010) (10)
SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet. (2021) (10)
Cloning and functional identification of slc 5 a 12 as a sodium-coupled low-affinity transporter for monocarboxylates ( SMCT 2 ) (2005) (9)
Transport of peptides in renal brush border membrane vesicles. Suitability of 125I-labelled tyrosyl peptides as substrates. (1991) (9)
Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis (2014) (9)
Dipeptide metabolism in the isolated perfused rat kidney. (1983) (9)
Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina (2020) (9)
Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness. (2011) (9)
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis (2021) (9)
Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. (1998) (8)
Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: A 1H-NMR-based metabolomic study in pancreatic cancer cells. (2020) (8)
Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina (2016) (8)
Molecular and functional characterization of the intestinal amino acid transporter B (1997) (8)
Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells. (1993) (8)
Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy (2021) (8)
The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study. (2004) (8)
Tooth Hypoplasia for Differential Diagnosis of Childhood Epilepsy Associated with SLC13A5 Mutations (2017) (8)
Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells. (2012) (7)
Transport of 5-oxoproline into rabbit renal brush border membrane vesicles. (1982) (7)
Regulation of Reduced-Folate Transporter-1 in Retinal Pigment Epithelial Cells by Folate (2005) (7)
Effects of phenothiazines on the Na+-H+ exchanger of the brush-border membrane from the proximal small intestine of the rabbit. (1988) (7)
Vitamin C Transporters in the Retina (2008) (7)
Electrogenic transport of 5-oxoproline in rabbit renal brush-border membrane vesicles. Effect of intravesicular potassium. (1983) (7)
Molecular cloning, expression, chromosomal localization, and regulation of the human placental taurine transporter (1993) (6)
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity. (2020) (6)
Peptide transport across the animal cell plasma membrane: recent developments. (1991) (6)
Expression and localization of GPR 109 A ( PUMA-G / HM 74 A ) mRNA and protein in mammalian retinal pigment epithelium (2009) (6)
Prolidase contamination in commercial bovine serum albumin. (1982) (6)
Development and radiosynthesis of the first 18 F-labeled inhibitor of monocarboxylate transporters (MCTs). (2019) (6)
Self-assembled nanoparticles with bilirubin/JPH203 alleviate imiquimod-induced psoriasis by reducing oxidative stress and suppressing Th17 expansion (2021) (6)
sigma Receptor ligand-induced up-regulation of the H(+)/peptide transporter PEPT1 in the human intestinal cell line Caco-2. (1999) (6)
SLC6A14 (ATB 0,+ ), A HIGHLY CONCENTRATIVE AND BROAD-SPECIFIC AMINO ACID TRANSPORTER, IS A NOVEL AND EFFECTIVE DRUG TARGET FOR TREATMENT OF ESTROGEN RECEPTOR-POSITIVE BREAST CANCER (2011) (6)
Use of human placenta in studies of monoamine transporters. (1998) (6)
Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues (2014) (6)
Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain. (1998) (6)
Association of 4 F 2 hc with light chains LAT 1 , LAT 2 or y + LAT 2 requires different domains (5)
Embryonic lethality in mice due to carnitine transporter OCTN2 defect and placental carnitine deficiency. (2018) (5)
Transplacental transport of water-soluble vitamins (1998) (5)
Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes. (1996) (5)
Development of Dipeptide Transport in Rat Renal Brush Border Menbranes: Studies with Glycylsarcosine (1987) (5)
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2 (2020) (5)
High fructose-mediated attenuation of insulin receptor signaling does not affect PDGF-induced proliferative signaling in vascular smooth muscle cells. (2016) (5)
The Sigma Receptor-1 (R1) Ligand Pentazocine (PTZ) Affords Marked Protection Against Neuronal Degeneration in the Ins2Akita Mouse Model of Retinopathy (2007) (5)
A traffic signal for heterodimeric amino acid transporters to transfer from the ER to the Golgi. (2009) (5)
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target (2021) (5)
RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy (2021) (5)
Drug Transport in the Placenta (2014) (5)
IFN g InducesDNAMethylation – SilencedGPR 109 A Expression via pSTAT 1 / p 300 and H 3 K 18 Acetylation in Colon Cancer (2015) (4)
A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects (2021) (4)
Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer (2022) (4)
Corrigendum: Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency (Human Molecular Genetics (1999) 8 (655-660)) (1999) (4)
Structure , function , and regional distribution of the organic cation transporter OCT 3 in the kidney (2000) (4)
Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant. (2018) (4)
Abstract 3325: Combination of DNMT and HDAC inhibitors reprogram cancer stem cell signaling to overcome drug resistance (2016) (4)
Rapid report Identity of the F 52 F 12 . 1 gene product in Caenorhabditis elegans as an organic cation transporter (1999) (4)
Breast Cancer Cell Migration and Metastasis (2010) (4)
Identity of the high-affinity sodium/carboxylate cotransporter NaC3 as the N-acetyl-L-aspartate transporter. (2006) (4)
Heterologous expression systems for studying placental transporters. (2006) (3)
Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate. (2005) (3)
Cloning of neutral amino acid transporter B0 from a human placental choriocarcinoma cell line (1996) (3)
Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions (2021) (3)
Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8). (2019) (3)
Evidence for two different broad-specific oligopeptide transporters in the 1 intestinal cell line Caco-2 and the colonic cell line CCD 841 2 3 (2011) (3)
Helping retina to breathe by increasing fetal hemoglobin production in RPE: relevance to outer retinal preservation in hypoxic conditions characteristic of aging and diabetes (2016) (3)
Abstract 4357: The lactate receptor Gpr81 on non-cancer cells promotes an immunosuppressive phenotype in the tumor microenvironment (2019) (3)
Systemic Route for Retinal Drug Delivery: Role of the Blood-Retinal Barrier (2011) (3)
Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling (2021) (3)
Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells (2019) (3)
Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia (2014) (3)
TRANSPORT OF WATER-SOLUBLE VITAMINS - A Review - (1998) (3)
Analysis of Folate Receptor (FR) Alpha in Ganglion and Müller Cells and FR Delta in RPE (2005) (2)
Placental transporters relevant to drug disposition across the maternal-fetal inferface (2003) (2)
Inhibitory effects of basic drugs on the sodium-dependent transport of L-alanine via system B0 in the small intestine. (2003) (2)
High‐ and low‐capacity taurine transport across the luminal membrane of the small intestinal epithelium (2008) (2)
Monomethylfumarate (MMF), a Novel Inducer Of Fetal Hemoglobin In Human Erythroid Progenitors and Retinal Pigment Epithelial Cells (2013) (2)
TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p (2021) (2)
Abstract 2037: The butyrate transporter SLC5A8 is a tumor suppressor in colon linked to dietary fiber content (2015) (2)
A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3 (2021) (2)
The y-aminobutyric acid transporter and its interaction with taurine in the apical membrane of the bovine retinal pigment epithelium (2005) (2)
Involvement of a Na+-coupled Oligopeptide Transport System for β-amyloid Peptide (Aβ1–42) in Brain Cells (2020) (2)
JPET #57109 1 Transport of Amino acid-based Prodrugs by the Na- and Cl- coupled Amino Acid Transporter ATB and Expression of the Transporter in Tissues Amenable for Drug Delivery (2003) (2)
Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues (2022) (2)
Cloning and characterization of a potential-sensitive organic cation transporter (OCT3) from rat placenta (1998) (2)
Cloning of a functional sodium-dependent pantothenate/biotin transporter from rabbit intestine and Caco-2 cells (1998) (2)
α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice (2021) (2)
Mole Rat with (2010) (2)
Molecular and Cellular Pathobiology SIRT 1 Is Essential for Oncogenic Signaling by Estrogen / Estrogen Receptor a in Breast Cancer (2011) (2)
Regulation of the cholesterol efflux transporters ABCA1/ABCG1 in retina in hemochromatosis and by the endogenous iron chelator 2,5-dihydroxybenzoic acid (2013) (2)
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity (2020) (2)
Role of dipeptidylpeptidase IV in renal handling of peptides. (1988) (2)
Direct evidence for functional coupling between human placental folate transporter and folate receptor in a heterologous expression system (1996) (2)
Editorial: Metabolite and Nutrient Transporters in Cancer-Cell Metabolism: Role in Cancer Progression and Metastasis (2022) (1)
RETRACTED ARTICLE: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells (2018) (1)
Regulation of Reduced-Folate Transporter (RFT-1) in Retinal Pigment Epithelial (RPE) Cells by Homocysteine (HCY) (2002) (1)
Abstract 18: Slc5a8 inactivation is associated with mammary gland involution delay, early onset of mammary tumorigenesis and accelerated lung metastasis (2012) (1)
A critical role for Slc5a8 in the suppression of colonic inflammation by commensal bacteria-derived metabolites (MUC9P.821) (2014) (1)
5-Hydroxy-L-lysine excretion in cystinuria (1985) (1)
Altered Retinal Vasculature in Hyperhomocysteinemic Mice (2012) (1)
Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer (2023) (1)
Abstract 17: Tumor-suppressive function of SLC5A8 in renal cancer cells (2012) (1)
Cystathionine Beta Synthase (cbs) Expression In Mouse Retina (2012) (1)
Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death (2016) (1)
Carbidopa suppresses estrogen receptor-positive breast cancer via AhR-mediated proteasomal degradation of ERα (2022) (1)
Alterations of retinal vasculature in cystathionine-beta-synthase heterozygous mice, a model of mild-moderate hyperhomocysteinemia (HHcy). (2014) (1)
Abstract 26: Deletion of Slc5a8 in mice promotes metabolic syndrome, colonic inflammation, and colon cancer: A phenomenon dependent on dietary fiber content (2012) (1)
Abstract 1557: The iron-overload genetic disease hemochromatosis potentiates colonic inflammation and colon carcinogenesis (2015) (1)
Expression of the Niacin Receptor GPR109A in Retina: More than Meets the Eye? (2013) (1)
Identification of the multivalent PDZ domain protein PDZK1 as a binding partner of sodium‐coupled monocarboxylate cotransporter 2 (SMCT2) by yeast two‐hybrid assay (2008) (1)
F004: Effect of nitric oxide donors and synthase agonist peptides on endothelial cell uptake of L-arginine (1998) (1)
The Anti-inflammatory Receptor GPR109A Regulates Angiopoeitin-like-4 (ANGPTL4) Expression in Retina: Potential New Link Between Regulation of Inflammatory and Angiogenic Signaling Mechanisms in Diabetic Retina (2012) (1)
Homocysteine Is an Oncometabolite in Breast Cancer, Which Promotes Tumor Progression and Metastasis (2014) (1)
D-serine and serine racemase in the retina (2011) (1)
Induction of the Cystine/Glutamate Transporter x -c by HIV-1 Transactivator Protein TAT in the Human Retinal Pigment Epithelial Cell Line ARPE-19 (2002) (1)
Induction of ATB0, an Amino Acid Transporter/Retroviral Receptor by HIV-1 TAT in RPE (2003) (1)
Abstract 4340: The amino acid transporter SLC6A14 is an effective drug target for treatment of pancreatic cancer (2014) (1)
Cloning of σ1 Receptor and Structural Analysis of Its Gene and Promoter Region (2007) (1)
Regulation Of Proton-coupled Folate Transporter (PCFT) By Fumaric Acid Esters (2011) (1)
Characterization of N 5-Methyltetrahydrofolate Uptake in Cultured Human Retinal Pigment Epithelial Cells (2005) (1)
Effects of Glucose and Insulin on GLAST and xc– Transporter Function in Primary Mouse Müller Cells (2005) (1)
SLC6A14 as a drug target for cancer therapy (2013) (1)
Cloning of a cDNA encoding the human sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate (1998) (1)
The Arginine Transporter ATB(0,+) is Upregulated in Colorectal Cancer (2004) (1)
Assessment of retinas of diabetic mice with mild elevation of plasma homocysteine. (2004) (1)
Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6) (2022) (1)
Regulation of Expression of Creatine Transporter in ARPE-19 Cells by HIV-1 TAT Protein (2003) (1)
Abstract 4838: Alpha-methyltryptophan, a blocker of the amino acid transporter SLC6A14, induces autophagy and apoptosis in SLC6A14-positive breast cancer and colon cancer cell lines (2010) (0)
Abstract 1479: Bacterial dysbiosis in the mouse model of hemochromatosis: Increased risk of colitis and colitis-associated colon cancer (2019) (0)
Peptide Tags and Domains for Expression and Detection of Mammalian Membrane Proteins at the Cell Surface. (2022) (0)
Keratinocytes join forces with immune cells in the prosecution of SMVT as a "false" biotin transporter. (2003) (0)
Abstract 3599: Expression and function of HFE in mammary gland iron homeostasis and its relevance to breast cancer (2012) (0)
Sigma Receptor (R) Ligands Prevent Apoptotic Retinal Ganglion Cell (RGC) Death Induced by Homocysteine (Hcy) & Glutamate (Glu) (2002) (0)
Retraction Note: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells (2018) (0)
624 Influence of Colonic Bacteria On the Expression of Host Intestinal Tract Genes Which Regulate Water and Electrolyte Absorption (2009) (0)
Mitochondrial histone deacetylase Sirt3 as a regulator of iron homeostasis and metabolite receptors Gpr91 and Gpr81 in retina (2015) (0)
Transient Elevation Of Bip/grp78 Is Associated With Early Preservation Of Sigma Receptor 1 (R1) Null Mouse Retina (2011) (0)
Mitoxantrone Resistance protein (MXR) is down-regulated in colorectal cancer (2004) (0)
Transport Of Oligopeptides In Corneal Epithelial Cells: An Ideal System For Delivery Of Peptides And Peptidomimetic Drugs Into The Anterior Chamber Of Eye (2012) (0)
Analysis of Sigma Receptor (R1) Binding to BiP in Oxidative Stress-Induced Death of Retinal Ganglion Cells (RGC) (2009) (0)
Effects of Folate Supplementation on Homocysteine-Induced Retinopathy in Cbs Mice (2007) (0)
Abstract 2402: Autocrine and paracrine role of tumor derived lactic acid in tumor growth and metastasis and in tumor cell nutrition (2018) (0)
Proton-coupled peptide transport in the small intestine and kidney (1994) (0)
Prevalence of HFE mutation in age-related macular degeneration (AMD) (2014) (0)
Abstract 3928: Genetic deletion or pharmacologic blockade of the amino acid transporter Slc6a14 in mice suppresses breast cancer induced by Polyoma middle T oncogene (2014) (0)
Regulation of Fas Expression in Nonhemopoietic Tumor Cells via IFN Regulatory Factor 8 Mediates Apoptosis (2007) (0)
The transport activity via human oligopeptide transporter (h-PEPT1) is regulated by the protonation/deprotonation state of the most crucial histidine, His57 (2006) (0)
Upregulation of xCT (x–c transporter) expression in HIV–1 Tat–transgenic mouse eyes (2004) (0)
IInduction of the Cystine/Glutamate Transporter xc- by Selenomethionine in ARPE-19 Cells (2010) (0)
Modulating inflammation in retina through targeting of GPR109A: Novel implications for therapeutic management of diabetic retinopathy (2013) (0)
Expression of Matriptase2 (TMPRSS6), a Proteolytic Regulator of Iron Homeostasis, in Retina, and Expression of Iron-regulatory Genes in Matriptase2-null Mouse Retina (2012) (0)
Transport of the photodynamic therapy agent 5-aminolevulinic acid by the amino acid transporter PAT1 (SLC36A1) and the dipeptide transporter PepT1 (SLC15A1). (2009) (0)
IFN-γ activates p300 to over-ride silencing effects of DNA methylation to activate GPR109A and SLC5A8 transcription (P2105) (2013) (0)
Expression of OCTN2, a Sodium-Dependent Carnitine Transporter, in Mouse Retina (2008) (0)
Iron Overload Associated Retinal Degeneration in Hfe Null Mouse (2007) (0)
Expression of HFE and Other Hemochromatosis Genes in Mouse Retina (2006) (0)
P57: The differential expression of apical membrane transporters in colorectal cancer can be exploited for the targeted delivery of short chain fatty acid prodrugs (2007) (0)
Evidence for a K/sup +/-H/sup +/ exchanger in rabbit renal cortical brush-border membrane vesicles (1987) (0)
Regulation of reduced-folate transporter-1 (RFT-1) in retinal pigment epithelial cells by folate (2013) (0)
242. Sert promoter region deletion and alcoholism risk (1998) (0)
Oxidative Stress Is Attenuated in Retinas of Ins2Akita Diabetic Mice Following Treatment With (+)-Pentazocine A Sigma Receptor-1-Specific Ligand (2008) (0)
Molecular Cloning and Functional Characterization of a Polyspecific Organic Anion Transporter from Caenorhabditis elegans 1 (1999) (0)
Abstract 3585: Amino acid transporter SLC6A14: A novel drug target for colorectal cancer (2019) (0)
Peptidases and peptide transport in renal brush-border membrane vesicles from rats with acute renal failure. (1990) (0)
Basic Science Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells (2013) (0)
Abstract 4477: Downregulation of ABCG2 expression in colitis and colon cancer: Relevance to iron overload, hemochromatosis and p53, and therapeutic use of carbidopa to reverse the downregulation (2018) (0)
Stimulation of the Cystine-Glutamate Transporter, System Xc- by the Anti-Psoriatic Drug Monomethylfumarate: Novel Mechanism for Antioxidant Protection of RPE (2012) (0)
Analysis of Folate Transport Proteins in Developing Mouse Retina (2003) (0)
Abstract 2194: SLC5A8, a novel transporter with tumor suppressor function, mediates its effect through survivin depletion (2011) (0)
Abstract #1537: Regulation of angiopoietin-like protein 4 (ANGPTL4) expression in breast cancer and breast cancer cell lines (2009) (0)
Uptake Measurements of Thyroid Hormones and Amino Acids in Cultured Cells (1996) (0)
Erratum: Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans (2014) (0)
Evidence for amino groups at the substrate binding site of the renal brush border membrane dipeptide transporter (1988) (0)
EM Immunolocalization of Folate Receptor alpha (FR) and Proton-Coupled Folate Transporter (PCFT) in Retinal Müller Cells (2009) (0)
Type 2 cGMP-Dependent Protein Kinase Regulates Proliferation and Differentiation in the 5 Colonic Mucosa 6 7 8 ( Running title : PKG 2 regulates colon homeostasis ) 9 10 11 (2012) (0)
Reversal of Premature Delivery Via Cox-2 Inhibition and GPR109A Deletion in Cystathionine-b-Synthase (CBS) Deficient Mice (2012) (0)
kinetics of the H rpeptide cotransport systems in intestine PEPT 1 and / kidney PEPT 2 (1997) (0)
Functional and Morphological Analysis of Retinas of Sigma Receptor 1 (R1) Null Mice (2010) (0)
Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics (2012) (0)
Expression of PUMA–G, a Novel Receptor for ß–Hydroxybutyrate, in Normal and Diabetic Mouse Retina (2006) (0)
558 Sodium-Coupled Transport of Butyrate By SLC5A8 Mediates Tumor Suppression in the Colon (2008) (0)
Localization of a New Proton-Coupled Folate Transporter (PCFT) in Retina (2008) (0)
Characterization of Expression and Binding Activity of Sigma Receptor–1 in Retinal Müller Cells (2006) (0)
Expression and Function of the Glutamine Transporter, System N, in Retinal Müller Cells (2005) (0)
Expression of Succinate Receptor Gpr91 in Retinal Pigment Epithelium (RPE) in Control and Hfe Knockout Mice (2010) (0)
The beta-Hydroxybutyrate Receptor GPR109A Functions as an Anti-inflammatory Receptor In Retinal Pigment Epithelium (RPE) (2011) (0)
TITLE : Homocysteine Is an Oncometabolite in Breast Cancer , Which Promotes Tumor Progression and Metastasis (2018) (0)
Expression of Iron-regulatory Protein Hemojuvelin in Retina and Its Regulation by Cytomegalovirus (2009) (0)
Retraction Note: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells (2018) (0)
Abstract 1100: p53 blocks TGFβ-induced breast cancer metastasis by downregulating angiopoietin-like 4 (2010) (0)
Expression of Succinate Receptor Gpr91 in Retinal Pigment Epithelium (RPE) in Control and Hfe Knockout Mice (2010) (0)
Abstract P005: SLC38A5 characterization and its tumor promoting role in pancreatic ductal adenocarcinoma (2023) (0)
Interleukin-1 receptors in human placenta and their role in the regulation of the serotonin transporter gent expression (1998) (0)
Cloning of a new organic cation transporter hOCTN2 from a human placental trophoblast cell line (1998) (0)
Potent Inhibition of Macropinocytosis by Niclosamide in Cancer Cells: A Novel Mechanism for the Anticancer Efficacy for the Antihelminthic (2023) (0)
Abstract B50: MEK inhibitors mount a two-pronged attack to kill estrogen receptor positive (ER+) breast cancer cells undergoing hormonal therapy: Attenuated autophagy and induction of apoptosis (2014) (0)
Influence of sigma receptor-1 (σR1) on inflammatory, stress and toxicity mediators in retinal Müller glia (rMG) (2014) (0)
Stimulation of Na+-coupled and H+-coupled Monocarboxylate Transporters in RPE by the Non-steroidal Anti-inflammatory Drug (NSAID) Diclofenac (2009) (0)
TAURINE AND GLUTAMINE TRANSPORT IS INCREASED IN JEJUNAL BRUSH BORDER MEMBRANE VESICLES AFTER SHORT-TERM TOTAL PARENTERAL NUTRITION IN RATS 466 (1997) (0)
Interferon Regulatory Factor 8 Mediates Apoptosis via Regulation of Fas and FLIP Expression (2008) (0)
Elevated Endogenous Homocysteine (HCY) Leads to Ganglion Cell Death and Disruption of Retinal Inner Nuclear and Plexiform Layers (2005) (0)
Sodium-dependent high-affinity binding sites for carnitine in human placental brush border membranes (1996) (0)
Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase (Mthfr) deficient mice. (2015) (0)
RETRACTED ARTICLE: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells (2018) (0)
Upregulation of the arginine transporter Atb(0,+) in colorectal cancer (2003) (0)
Fetal hemoglobin induction by monomethylfumarate: relevance to prevention and treatment of sickle cell retinopathy (SR) (2014) (0)
Sigma Receptor Ligands as Neuroprotectants Against Apoptotic Retinal Ganglion Cell (RGC) Death in a Streptozotocin (STZ)-Induced Mouse Model of Diabetes (2003) (0)
Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression (2018) (0)
Expression of Iron Regulatory Proteins in Diabetic Retina (2015) (0)
Abstract 1310: SLC5A8 functions as a tumor suppressor through redistribution and depletion of survivin (2012) (0)
The substrate specificity of the human H + -coupled amino acid transporter (hPAT1) is similar to the imino acid carrier in rat small intestine (2003) (0)
Analysis of the Mechanism by Which the Sigma Receptor (R1) Ligand (+)-pentazocine ((+)-PTZ) Protects Against Excitotoxic Death in Primary Retinal Ganglion Cells (1ºRGC) (2008) (0)
Abstract LB-236: Differential regulation of STAT3 in mammary gland involution as well as in mammary tumorigeneis (2010) (0)
Targeting the achilles heel of cancer: Nutrient transporters (2018) (0)
The Na+/Cl−-Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis (2017) (0)
Functional characterization of Na+-coupled dicarboxylate transporters in central nervous system (2005) (0)
Abstract 4459: a-Methyltryptophan (a-MT) inhibits estrogen receptor (ER)-positive breast cancer growth through blockade of SLC6A14 (2011) (0)
AM Suppression of MiR-18 b on high-glucose-induced proliferation of human retinal endothelial cells by targeting insulin growth factor-1 ( IGF-1 ) / IGF 1 R signaling pathways (2015) (0)
Characterization of antibodies to intestinal NA+dependent neural amino acid transporter (B0) (2000) (0)
3P-216 The role of the acidic residue near PSB in Cl^- pump by Natronomonas pharaonis halorhodopsin(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
Abstract 348: Amino acid-based prodrugs of gemcitabine - a therapeutic option to overcome chemoresistance in pancreatic cancer (2015) (0)
Abstract 3140: Constitutive and regulated expression of GPR109A by DNA methylation and IFN-γ in human colon carcinoma cells (2012) (0)
Expression of SMCT2, a Low-Affinity Sodium-Coupled Monocarboxylate Transporter, in Retina (2007) (0)
Absence of Iron-regulatory Protein Hfe Results in Hyperproliferation of Retinal Pigment Epithelium Possibly Through Induction of Cystine/glutamate Transporter (2009) (0)
xCT Expression and Regulation in Retinal Ganglion Cells (RGC-5) Treated with Glutamate (2003) (0)
Abstract 2461: SLC5A8: A strategic target for advanced metastatic breast cancer (2014) (0)
Placenta as a nutritional unit (2004) (0)
Halorhodopsin from Natronomonas pharaonis (pHR) is a chloride pump : Heterologous expression of pHR in Xenopus oocytes and electrophysiological characterization of its light-driven Cl- pump (2006) (0)
Biochemical and molecular characterization of the most-common SLC13A5-Epilepsy causing missense-mutations. (2023) (0)
Angiocidin, a novel thrombospondin-1 receptor, and matrix metalloproteinase-9 are up-regulated in colon cancer (2004) (0)
Abstract 1015: Repurposing the FDA-approved drug carbidopa to treat human cancers (2016) (0)
Preferred blood-brain transfer of O-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) into the porcine brain (2007) (0)
Functional Analysis of D–Serine Transport in Retinal Müller Cells (2006) (0)
Abstract 2198: Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate (2011) (0)
pH-dependent £uoride transport in intestinal brush border membrane vesicles (1998) (0)
Inactivation in Breast Cancer Molecular Mechanism of SLC5A8 (2014) (0)
GLAST and System Xc–: Transporter Response to Prolonged Hyperglycemia and Acute Oxidative Stress in Primary Mouse Müller Cells (2006) (0)
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin (2020) (0)
Expression Pattern of SMCT, a Sodium–Coupled Monocarboxylate Transporter, in Retina (2005) (0)
Abstract LB-142: Functional role of DNA methyltransferase1 (DNMT1) in regulation of mammary stem/progenitor and cancer stem cells (2015) (0)
Transport via SLC 5 A 8 ( SMCT 1 ) Is Obligatory for 2-Oxothiazolidine-4-Carboxylate to Enhance Glutathione Production in Retinal Pigment Epithelial Cells (2011) (0)
Gpr91, a pro-angiogenic receptor for succinate, is upregulated in hemojuvelin-null mouse retina via increased BMP6 signaling (2014) (0)
Expression of the lactate receptor Gpr81 in mouse retina and its regulation in mouse models of hemochromatosis and diabetes (2014) (0)
Regulation of the cholesterol efflux transporter ABCA1 by the niacin receptor GPR109A: potential relevance to drusen biogenesis and inflammation in age-related macular degeneration (AMD) (2013) (0)
Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells (2019) (0)
GPR109A, A G-PROTEIN-COUPLED RECEPTOR FOR NICOTINATE AND THE BACTERIAL FERMENTATION PRODUCT BUTYRATE, FUNCTIONS AS A TUMOR SUPPRESSOR IN COLON (2009) (0)
Sigma Receptor (R1) is Expressed in Retinal Ganglion Cells (RGC) Under Normal and Diabetic Conditions (2002) (0)
Increased Susceptibility to Retinal Stress in Mice Lacking Sigma Receptor 1 (R1) (2012) (0)
Systeme de transport couple na+ et ci- pour peptides opioides endogenes (2005) (0)
Abstract 2851: Genetic polymorphisms and expression of SLC5A8 in prostate cancer (2010) (0)
A novel method to study binding of protein antigens to syncytiotrophoblast microvilli (1992) (0)
Comprehensive characterization of retinal phenotypic changes in methylene tetrahydrofolate reductase (MTHFR) deficient mice: a model of hyperhomocysteinemia (HHcy) (2014) (0)
Expression of Functional Human Na+- Coupled Citrate Transporter (SLC13A5) in the Yeast Pichia pastoris (2020) (0)
Tyrosine phosphorylation-dependent regulation of the amino acid transporter B) in JAR human placental choriocarcinoma cells (1996) (0)
(+)-Pentazocine ((+)-PTZ), a high affinity sigma 1 receptor (σ1R) ligand preserves cone function in the Pde6rd10 (Rd10) mouse model of retinitis pigmentosa (2015) (0)
The Cysteine Prodrug L-2-Oxothiazolidine-4-Carboxylic Acid (OTC) Elicits Potent Antioxidant and Anti-inflammatory Effects in RPE: Relevance to Treatment of Age-Related Macular Degeneration (2012) (0)
Upregulation of GPR109A, a Novel Receptor for β-Hydroxybutyrate, in Diabetic Retina (2010) (0)
The Sigma Receptor (R1) Ligand (+)-Pentazocine (PTZ) Attenuates Glutamate-Induced Death of Primary Mouse Retinal Ganglion Cells (1ºGC) (2007) (0)
2P302 Mechanism of proton transport via azide-bound halorhodopsin from Natronomonas pharaonis(Native and artificial biomembranes-transport,Poster Presentations) (2007) (0)
Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg (1990) (0)
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity (2020) (0)
Abstract 4032: SIRT1 modulates E2/ERα-associated oncogenic signaling in human breast cancer (2011) (0)
ATB0,+ is a Transporter for Homocysteine (Hcy) in Retinal Cells (2003) (0)
Abstract 3699: Involvement of p53 and KRAS in the regulation of SLC38A5 in colon cancer (2023) (0)
Structural Insights and Classification of the Disease-Causing Mutations in Human Na+- Coupled Citrate Transporter (NACT) using a Homology Modeling Approach (2021) (0)
Changes over time of papillary thyroid carcinoma and total thyroidectomy rates. (2016) (0)
proliferation and differentiation in the colonic mucosa Type 2 cGMP-dependent protein kinase regulates (2012) (0)
Chronic antidepressant treatment effects on kinase gene expression patterns (2001) (0)
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina (2014) (0)
Abstract 537: Platelet Derived Growth Factor Induced Vascular Smooth Muscle Cell Proliferation is Associated with Enhanced Glut1 Expression/glycosylation and Glucose Uptake (2013) (0)
Abstract 2785: Carbidopa/α-methyltryptophan as an ideal combination therapy for breast cancer (2023) (0)

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