Van Luu‐the
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- Masters Biochemistry Stanford University
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(Suggest an Edit or Addition)Van Luu‐the's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. (2003) (534)
- Is dehydroepiandrosterone a hormone? (2005) (454)
- The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology (1997) (411)
- Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. (1999) (368)
- DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging (1998) (350)
- DHEA and Its Transformation into Androgens and Estrogens in Peripheral Target Tissues: Intracrinology (2001) (348)
- Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-lsomerase in Human Adrenals and Gonads (1991) (345)
- Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides (2009) (333)
- 17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes. (1999) (304)
- Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease. (2000) (295)
- Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction. (2005) (286)
- DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology (1995) (270)
- Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase (2001) (257)
- Characteristics of human types 1, 2 and 3 17β-hydroxysteroid dehydrogenase activities: Oxidation/reduction and inhibition (1995) (234)
- Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. (2002) (226)
- Characteristics of a Highly Labile Human Type 5 17β-Hydroxysteroid Dehydrogenase1. (1999) (224)
- Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues (1992) (211)
- Structure of human type II 5 alpha-reductase gene. (1992) (192)
- Androgen biosynthetic pathways in the human prostate. (2008) (190)
- Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. (1991) (174)
- Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women. (2006) (172)
- Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. (1990) (171)
- EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium (1999) (166)
- The intracrine sex steroid biosynthesis pathways. (2010) (157)
- Gonadotropin-releasing hormone agonists in the treatment of prostate cancer. (2005) (154)
- Role of 17β-Hydroxysteroid Dehydrogenases in Sex Steroid Formation in Peripheral Intracrine Tissues (2000) (147)
- Localization of Type 5 17β-Hydroxysteroid Dehydrogenase, 3β-Hydroxysteroid Dehydrogenase, and Androgen Receptor in the Human Prostate by in Situ Hybridization and Immunocytochemistry. (1999) (139)
- Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues (1992) (139)
- The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. (1997) (134)
- Assessment of steroidogenesis and steroidogenic enzyme functions (2013) (132)
- Structure of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) gene : adrenal and gonadal specificity (1991) (132)
- Intracrinology and The Skin (2001) (122)
- Androgen metabolism in adipose tissue: Recent advances (2009) (114)
- Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta. (1992) (111)
- Characterization, Expression, and Immunohistochemical Localization of 5α-Reductase in Human Skin (1994) (110)
- Type 5 17β-hydroxysteroid dehydrogenase: its role in the formation of androgens in women (2001) (110)
- Science behind total androgen blockade: from gene to combination therapy. (1993) (109)
- Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. (2001) (107)
- Immunocytochemical Localization of Type 5 17 β-Hydroxysteroid Dehydrogenase in Human Reproductive Tissues (1999) (105)
- Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride (2010) (103)
- Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women (2010) (102)
- Characterization of a human 20alpha-hydroxysteroid dehydrogenase. (2000) (100)
- Structure and tissue-specific expression of 3ß-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues (1992) (97)
- Oestrogenic Regulation of Pro‐Opiomelanocortin, Neuropeptide Y and Corticotrophin‐Releasing Hormone mRNAs in Mouse Hypothalamus (2007) (91)
- Characterization, Expression, and Immunohistochemical Localization of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase in Human Skin (1992) (90)
- Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. (2006) (85)
- Molecular Cloning of Human Type 3 3α-Hydroxysteroid Dehydrogenase That Differs from 20α-Hydroxysteroid Dehydrogenase by Seven Amino Acids (1996) (84)
- Steroid sulfotransferases. (1996) (82)
- Evidence of heterogeneity and quantitative differences of the type 1 5alpha-reductase expression in cultured human skin cells--evidence of its presence in melanocytes. (1998) (82)
- 11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues (1994) (80)
- Molecular Characterization of a First Human 3(α→β)-Hydroxysteroid Epimerase* (2000) (80)
- Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis. (2009) (79)
- Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase. (2000) (77)
- Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women. (2009) (76)
- Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™ (2009) (74)
- Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3β‐hydroxy‐5‐ene steroid dehydrogenase/Δ5‐Δ4 isomerase (1989) (73)
- Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. (2003) (72)
- Human Types 1 and 3 3α-Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution1 (2001) (72)
- Immunocytochemical Localization of 5α-Reductase in Rat Brain (1994) (70)
- Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads. (1991) (70)
- Localization of 3β-Hydroxysteroid Dehydrogenase in Rat Brain as Studied by in Situ Hybridization (1994) (69)
- Expression of aromatase and 17β-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer An immunocytochemical study (2006) (68)
- gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. (2000) (68)
- Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol. (1999) (68)
- Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cells (1992) (65)
- Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue (2010) (63)
- Cellular localization of estrogen receptor beta messenger ribonucleic acid in cynomolgus monkey reproductive organs. (1999) (63)
- Molecular biology and genetics of the 3 beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. (1996) (62)
- Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. (1999) (62)
- Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. (2005) (62)
- Molecular biology and genetics of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family (1996) (61)
- Immunocytochemical Localization and Biological Activity of Hydroxysteroid Sulfotransferase in the Frog Brain (1999) (60)
- Local androgen inactivation in abdominal visceral adipose tissue. (2003) (58)
- Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes. (1995) (57)
- Localization of 3β-Hydroxysteroid DehydrogenaseΔ5-Δ4-Isomerase in Rat Gonads and Adrenal Glands by Immunocytochemistry and in Situ Hybridization (1990) (56)
- Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. (1993) (56)
- Changes in 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Messenger Ribonucleic Acid, Activity and Protein Levels During the Estrous Cycle in the Bovine Ovary* (1990) (56)
- Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (1995) (54)
- Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Expression and Activity in the Hypophysectomized Rat Ovary: Interactions between the Stimulatory Effect of Human Chorionic Gonadotropin and the Luteolytic Effect of Prolactin* (1990) (53)
- Immunocytochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human ovary. (1992) (53)
- Ontogeny and subcellular localization of 3β-hydroxysteroid dehydrogenase (3β-HSD) in the human and rat adrenal, ovary and testis (1992) (53)
- Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5α-reductase, 20α-hydroxysteroid dehydrogenase and estrogen sulfotransferase (2005) (52)
- Evidence for distinct dehydrogenase and isomerase sites within a single 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein. (1991) (52)
- Cloning and expression of cDNA encoding human placental estrogen sulfotransferase (1994) (51)
- Inhibitors of type II 17β-hydroxysteroid dehydrogenase (2001) (51)
- Localization by in situ hybridization of steroid 5alpha-reductase isozyme gene expression in the human prostate and preputial skin. (1998) (50)
- Updated survey of the steroid-converting enzymes in human adipose tissues (2015) (50)
- History of LHRH agonist and combination therapy in prostate cancer (1996) (50)
- Androgen Formation and Metabolism in the Pulmonary Epithelial Cell Line A549: Expression of 17β-Hydroxysteroid Dehydrogenase Type 5 and 3α-Hydroxysteroid Dehydrogenase Type 3. (2000) (50)
- Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibians (2001) (50)
- Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase. (2007) (49)
- Structure of the Human 3α-Hydroxysteroid Dehydrogenase Type 3 in Complex with Testosterone and NADP at 1.25-Å Resolution* (2001) (49)
- Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland. (2001) (49)
- Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina. (2004) (49)
- Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. (1999) (48)
- Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. (2002) (48)
- Immunocytochemical localization of type I 17β-hydroxysteroid dehydrogenase in the rat brain (1995) (47)
- Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17α‐hydroxylase/C17, 20‐lyase (P450C17) in the frog brain and pituitary (2007) (47)
- Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities. (1999) (46)
- Light Microscopic Immunocytochemical Localization of 3β-Hydroxy-5-ene-steroid dehydrogenase/Δ5-Δ4- Isomerase in the Gonads and Adrenal Glands of the Guinea Pig (1990) (46)
- Cations Inhibit Specifically Type I 5α-Reductase Found in Human Skin (1995) (46)
- Developmental regulation of connexin 43 expression in fetal mouse testicular cells (2001) (46)
- Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid. (2005) (45)
- Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain (2006) (45)
- Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ 5-Δ 4 isomerase (3β-HSD) in human adrenal gland performed by immunocytochemistry (1990) (44)
- The 3β-Hydroxysteroid Dehydrogenase/Isomerase Gene Family: Lessons from Type II 3β-HSD Congenital Deficiency (1996) (44)
- Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase: Chemical Synthesis and Structure−Activity Relationship (2005) (44)
- Progesterone metabolism in adipose cells (2009) (43)
- Structure-based Inhibitor Design for an Enzyme That Binds Different Steroids (2007) (43)
- Purification of Microsomal and Mitochondrial 3β‐Hydroxysteroid Dehydrogenase/Δ5‐Δ4 Isomerase from Human Placenta (1990) (42)
- Immunohistochemical localization and biological activity of 3β-hydroxysteroid dehydrogenase and 5α-reductase in the brain of the frog, Rana esculenta, during development (2010) (42)
- Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line. (2010) (42)
- Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues. (1992) (41)
- Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. (2004) (41)
- Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (1994) (40)
- Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord (2005) (39)
- Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450. (1980) (39)
- Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. (2003) (38)
- Inhibitors of type 1 17β-hydroxysteroid dehydrogenase with reduced estrogenic activity: Modifications of the positions 3 and 6 of estradiol (2005) (38)
- Visceral adiposity and endothelial lipase. (2006) (38)
- Androgens in the maternal and fetal circulation: association with insulin resistance (2013) (37)
- Differential estrogenic 17β-hydroxysteroid dehydrogenase activity and type 12 17β-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes (2009) (37)
- Pangenomic changes induced by DHEA in the skin of postmenopausal women (2008) (36)
- Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG) (2006) (35)
- C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation. (2007) (35)
- Localization and glucocorticoid regulation of 11β-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain (2007) (35)
- Human phenol sulfotransferase gene contains two alternative promoters: Structure and expression of the gene. (1996) (34)
- Regulation of Neurosteroid Biosynthesis by Neurotransmitters and Neuropeptides (2011) (34)
- Characterization of 17α-hydroxysteroid dehydrogenase activity (17α-HSD) and its involvement in the biosynthesis of epitestosterone (2005) (34)
- Comparative biosynthetic pathway of androstenol and androgens (2001) (33)
- Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. (2009) (33)
- Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase close to D1S514 and the centromeric D1Z5 locus (1995) (32)
- Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes. (2012) (32)
- Cloning and characterization of human form 2 type 7 17β-hydroxysteroid dehydrogenase, a primarily 3β-keto reductase and estrogen activating and androgen inactivating enzyme (2005) (32)
- Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17 (2002) (32)
- Immunohistochemical localization of 3β‐hydroxysteroid dehydrogenase and 5α‐reductase in the brain of the African lungfish Protopterus annectens (2001) (30)
- Neuropeptide Y Inhibits the Biosynthesis of Sulfated Neurosteroids in the Hypothalamus through Activation of Y1 Receptors. (2002) (30)
- Characterization of a human 20-hydroxysteroid dehydrogenase (2000) (30)
- Expression of Enzymes Involved in Estrogen Metabolism in Human Prostate (2006) (29)
- Regulation of Neurosteroid Biosynthesis in the Frog Diencephalon by GABA and Endozepines (2001) (29)
- Dinucleotide repeat polymorphisms in the HSD3B2 gene. (1994) (29)
- Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues. (2004) (29)
- Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line (2009) (29)
- Expression of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) and 17B-hydroxysteroid dehydrogenase (17β-HSD) in adipose tissue (1991) (29)
- Contents Vol. 54, 2000 (2001) (28)
- Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. (2009) (28)
- Localization of 17 beta-hydroxysteroid dehydrogenase throughout gestation in human placenta. (1991) (28)
- Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin. (1992) (28)
- The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. (2008) (28)
- Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase. (2003) (27)
- Ontogenesis of 3β-Hydroxysteroid DehydrogenaseΔ5-Δ4 Isomerase in the Rat Adrenal as Revealed by Immunocytochemistry and in Situ Hybridization (1991) (27)
- Expression and activity of 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women. (2005) (27)
- Immunohistochemical localization of 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5----delta 4 isomerase in human placenta and fetal membranes throughout gestation. (1992) (27)
- Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal and gonadal specificity. (1991) (27)
- Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors (2002) (27)
- Purification, Cloning, Complementary DNA Structure, and Predicted Amino Acid Sequence of Human Estradiol 17β‐Dehydrogenase (1990) (26)
- Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3β-hydroxy-5-ene-steroid dehydrogenase/Δ 5-Δ 4 isomerase (3β-HSD) expression and activity in the rat ovary (1990) (26)
- Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity. (1995) (26)
- Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases. (2007) (26)
- Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. (2001) (25)
- Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey (2007) (25)
- 3β-Sulfamate Derivatives of C19 and C21 Steroids Bearing a t -Butylbenzyl or a Benzyl Group: Synthesis and Evaluation as Non-estrogenic and Non-androgenic Steroid Sulfatase Inhibitors (2003) (25)
- Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus. (2007) (25)
- Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in human testis as studied by immunocytochemistry. (1991) (25)
- Structure and activity of the murine type 5 17β-hydroxysteroid dehydrogenase gene (1999) (25)
- Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. (2005) (25)
- Localization of Type 8 17β-hydroxysteroid Dehydrogenase mRNA in Mouse Tissues as Studied by In Situ Hybridization (2005) (24)
- Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ5 — Δ4 isomerase (3β-HSD) in rat testis as studied by immunocytochemistry (1993) (24)
- Steroid metabolism and profile of steroidogenic gene expression in Episkin™: High similarity with human epidermis (2007) (24)
- Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase (2001) (24)
- Structure-function relationships and molecular genetics of the 3β-hydroxysteroid dehydrogenase gene family (1995) (24)
- Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. (2008) (23)
- Steroid Biosynthesis within the Frog Brain (2009) (23)
- Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase. (2000) (23)
- Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization. (1993) (22)
- Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17. (1989) (22)
- Immunohistochemical localization of 3 beta-hydroxysteroid/delta 5-delta 4-isomerase, tyrosine hydroxylase and phenylethanolamine N-methyl transferase in adrenal glands of sheep fetuses throughout gestation and in neonates. (1992) (22)
- Expression of 17β-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: A correlation to clinicopathological parameters (2008) (22)
- Characterization, expression, and immunohistochemical localization of 5 alpha-reductase in human skin. (1994) (22)
- Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3β-hydroxysteroid dehydrogenase/5→4-ene-isomerase activity (1990) (22)
- Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone. (1996) (22)
- Comparison of crystal structures of human type 3 3α‐hydroxysteroid dehydrogenase reveals an “induced‐fit” mechanism and a conserved basic motif involved in the binding of androgen (2005) (22)
- Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities. (2001) (22)
- Immunocytochemical localization of 5 alpha-reductase in rat brain. (1994) (21)
- Repetitive and site-specific molecular staging of prostate cancer using nested reverse transcriptase polymerase chain reaction for prostate specific antigen and prostate specific membrane antigen (2004) (21)
- Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. (2007) (20)
- Androgen formation and metabolism in the pulmonary epithelial cell line A549: expression of 17beta-hydroxysteroid dehydrogenase type 5 and 3alpha-hydroxysteroid dehydrogenase type 3. (2000) (20)
- In vivo evidence for the production of sulfated steroids in the frog brain. (2000) (20)
- Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. (2001) (19)
- Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes. (1990) (19)
- Characterization of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. (2001) (19)
- Reversal of divergent differentiation by ras oncogene-mediated transformation. (1992) (18)
- Major impact of hormonal therapy in localized prostate cancer—death can already be an exception (2004) (18)
- Sex-related Expression of 20α-hydroxysteroid Dehydrogenase mRNA in the Adult Mouse (2003) (18)
- Isolation and characterization of a cDNA encoding mouse 3α-hydroxysteroid dehydrogenase An androgen-inactivating enzyme selectively expressed in female tissues (2006) (18)
- ["Intracrinology". Autonomy and freedom of peripheral tissues]. (1995) (18)
- Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids. (1996) (17)
- Modulation of the androgenic response by recombinant human 11-cis retinol dehydrogenase (2001) (17)
- Response of the adipose tissue transcriptome to dihydrotestosterone in mice. (2008) (17)
- Neurosteroid Biosynthesis in the Brain of Amphibians (2011) (16)
- Assessment of steroidogenic pathways that do not require testosterone as intermediate (2011) (16)
- Localization of type 7 17β-hydroxysteroid dehydrogenase in mouse tissues In situ hybridization studies (2005) (15)
- Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(α→β)-hydroxysteroid epimerase (2001) (15)
- Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates. (2002) (15)
- Androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase (2000) (15)
- Inhibitors of type II 17beta-hydroxysteroid dehydrogenase. (2001) (15)
- Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. (2006) (15)
- Neuropeptide Y inhibits the biosynthesis of sulfated neurosteroids in the hypothalamus through activation of Y(1) receptors. (2002) (14)
- Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus (2006) (14)
- Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2 (2015) (14)
- Immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the brain of the African lungfish Protopterus annectens. (2001) (14)
- Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization (2005) (14)
- Ontogeny of 3β‐Hydroxysteroid Dehydrogenase and 5α‐Reductase in the Frog Brain (2005) (13)
- Changes in 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase messenger ribonucleic acid, activity and protein levels during the estrous cycle in the bovine ovary. (1990) (13)
- Cellular Localization of mRNA Expression of Enzymes Involved in the Formation and Inactivation of Hormonal Steroids in the Mouse Prostate (2004) (13)
- Cations inhibit specifically type I 5 alpha-reductase found in human skin. (1995) (13)
- Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells (2002) (13)
- Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry (2007) (13)
- Assignment1 of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15→p14 and mouse chromosome 13 region A2 by in situ hybridization: Identification of a new syntenic relationship (1999) (13)
- Microarray analysis of survival pathways in human PC-3 prostate cancer cells. (2007) (13)
- Expression of 11β-hydroxysteroid Dehydrogenase Type 1 in Breast Cancer and Adjacent Non-Malignant Tissue. An Immunocytochemical Study (2011) (13)
- Isolation and characterization of a stereospecific 3beta-hydroxysteriod sulfotransferase (pregnenolone sulfotransferase) cDNA. (1996) (13)
- Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study (2009) (12)
- Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. (1992) (12)
- Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland (2012) (12)
- Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization. (2009) (12)
- Assignment1 of steroid 5β-reductase (SRD5B1) and its pseudogene (SRD5BP1) to human chromosome bands 7q32→q33 and 1q23→q25, respectively, byin situ hybridization (1999) (12)
- Changes in the abundance of mRNA for type-I 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase in the human placenta and fetal membranes during pregnancy and labor. (1993) (12)
- Expression of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) in adipose tissue. (1991) (12)
- Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family (2007) (11)
- Vinyl fluoride as a mimic of the "intermediate' enol form in the 5 alpha-reductase transformation: synthesis and in vitro activity of (N-1',1'-dimethylethyl)-3-haloandrost-3,5-diene-17 beta-carboxamides. (1996) (11)
- Structure, regulation and role of 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues. (1994) (11)
- Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase (2010) (11)
- The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells. (2004) (11)
- Structure-activity relationships of a series of analogs of the endozepine octadecaneuropeptide (ODN(11)(-)(18)) on neurosteroid biosynthesis by hypothalamic explants. (2007) (11)
- Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region. (1995) (11)
- Target deletion of the bifunctional type 12 17β-hydroxysteroid dehydrogenase in mice results in reduction of androgen and estrogen levels in heterozygotes and embryonic lethality in homozygotes (2010) (11)
- Immunoelectron microscopic localization of 3 (cid:1) -hydroxysteroid dehydrogenase and type 5 17 (cid:1) -hydroxysteroid dehydrogenase in the human prostate and mammary gland (2001) (11)
- Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization. (2004) (10)
- Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1). (1999) (10)
- Conversion of pregnenolone to DHEA by human 17alpha-hydroxylase/17, 20-lyase (P450c17). Evidence that DHEA is produced from the released intermediate, 17alpha-hydroxypregnenolone. (2000) (10)
- 3-Hydroxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17β-carbolactone as inhibitor of 17β-hydroxysteroid dehydrogenase type 2 (1994) (10)
- Crystallization and preliminary crystallographic results of apo and complex forms of human dehydroepiandrosterone sulfotransferase. (2001) (10)
- Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. (2013) (10)
- 3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines (2006) (10)
- High metabolization of catecholestrogens by type 1 estrogen sulfotransferase (hEST1) (2001) (9)
- Rat liver plasma membrane Ca2+- or Mg2+-activated ATPase. Evidence for proton movement in reconstituted vesicles. (1987) (9)
- Expression of human 17 beta-hydroxysteroid dehydrogenase in mammalian cells. (1992) (9)
- Molecular Biology of Steroid Sulfotransferases a (1996) (8)
- Suppression of luteal steroidogenesis by an LHRH antagonist (Nal-Lys antagonist: antide) in vitro during early pregnancy in the rat. (1994) (8)
- Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression. (2004) (8)
- Inhibition of steroidogenesis by luteal cells of early pregnancy in the rat in response to in vitro administration of a gonadotropin- releasing hormone agonist (1994) (8)
- Ontogeny and subcellular localization of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) in the human and rat adrenal, ovary and testis. (1992) (7)
- Cloning and expression of human tyrosine aminotransferase cDNA. (1995) (7)
- Differential inhibition of dehydrogenase and 5-ene→4-ene isomerase activities of purified 3β-hydroxysteroid dehydrogenase. Evidence for two distinct sites (1991) (7)
- Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) expression and activity in the rat ovary. (1990) (6)
- Regulation of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase expression and activity in the hypophysectomized rat ovary: interactions between the stimulatory effect of human chorionic gonadotropin and the luteolytic effect of prolactin. (1990) (6)
- First Inhibitors of the Steroidogenic Enzyme Type 7 17β-Hydroxysteroid Dehydrogenase (2004) (5)
- Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in human adrenal gland performed by immunocytochemistry. (1990) (5)
- Expression of 5α-reductase type 1 in breast cancer and adjacent non-malignant tissue: an immunohistochemical study (2010) (5)
- Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase. (1989) (5)
- Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization. (1991) (5)
- Localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in rat gonads and adrenal glands by immunocytochemistry and in situ hybridization. (1990) (5)
- Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3α-hydroxysteroid dehydrogenase at 1.8 Å resolution (2001) (5)
- Assignment of steroid 5beta-reductase (SRD5B1) and its pseudogene (SRD5BP1) to human chromosome bands 7q32-->q33 and 1q23-->q25, respectively, by in situ hybridization. (1999) (4)
- Androgens, DHEA and breast cancer (2005) (4)
- Inhibition of human-type 1 3β-hydroxysteroid deshydrogenase/Δ5-Δ4-isomerase expression using siRNA (2005) (4)
- Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship. (2005) (4)
- Molecular Cloning of Rat 3β-HSD: Structure of Two Types of cDNAs and Differential Expression of Corresponding mRNAs in the Ovary (1991) (4)
- Inhibition of human-type 1 3beta-hydroxysteroid deshydrogenase/Delta(5)-Delta(4)-isomerase expression using siRNA. (2005) (4)
- Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase. (2001) (4)
- Ontogeny of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the frog brain. (2005) (3)
- Immunohistochemical Localization of Hydroxysteroid Sulfotransferase and Sulfatase in the Brain of Rana esculenta Tadpoles (2009) (3)
- Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase close to D1S514 and the centromeric D1Z5 locus. (1995) (3)
- Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3 alpha-hydroxysteroid dehydrogenase at 1.8 A resolution. (2001) (2)
- Structure and Control of Expression of the 3βHSD and 17βHSD Genes in Classical Steroidogenic and Peripheral Intracrine Tissues (1993) (2)
- DHEA, The Precursor of Androgens and Estrogens in Peripheral Tissues in the Human: Intracrinology (2000) (2)
- Parallel solid-phase synthesis of 3beta-peptido-3alpha-hydroxy-5alpha-androstan-17-one derivatives for inhibition of type 3 17beta-hydroxysteroid dehydrogenase. (2001) (2)
- Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase. (2000) (2)
- Molecular Genetics, Structure-Function Relationships, and Tissue-Specific Expression and Regulation of the 3βHSD Gene Family (1994) (2)
- Light microscopic immunocytochemical localization of 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase in the gonads and adrenal glands of the guinea pig. (1990) (2)
- Purification of cytochrome P-450 by double chromatography on substituted Sepharose. Effect of type I and type II ligands [proceedings]. (1979) (1)
- RELATION BETWEEN IN VITRO ALTERATION BY ALLYL COMPOUNDS AND FORMS OF CYTOCHROME P-450 (1980) (1)
- Crystal structure of 17alpha-hydroxysteroid dehydrogenase in its apo-form (2006) (1)
- Purified Microsomal and Mitochondrial 3β‐Hydroxysteroid Dehydrogenase/Δ4‐Δ5 Isomerase from Human Placenta. (1990) (1)
- Subject Index Vol. 54, 2000 (2001) (1)
- Characterization , Expression , and Intmunohistochemical Localization of 3 fi-Hydroxysteroid Dehydrogenase / d 5d 4 Isomerase in Human Skin (2010) (1)
- CYP450 characterization of the reconstructed human epidermis Episkin™ involved in xenobiotic metabolism (2008) (1)
- [From the gene to the clinic: prostate cancer death can now be an exception?]. (2003) (1)
- Analysis of phases 1 and 2 metabolism enzymes in human skin suggests important role of phase 2 enzymes in the detoxification (2008) (1)
- Quantification of phases 1 and 2 metabolism enzymes in Episkin™ and epidermis (2008) (0)
- Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation (2006) (0)
- Crystal structure of human 17bet a-hydroxysteroid dehydrogenase type 5 in complexes with PEG and NADP (2006) (0)
- The Passing of Dr. Fernand Labrie (1937–2019): The legacy of excellence in science (2019) (0)
- Control of neurosteroid biosynthesis by neurotransmitters and neuropeptides (2001) (0)
- Antagonistic activity of acolbifene, fulvestrant, tamoxifen, and raloxifene on cancer-associated genes in the mouse mammary gland. (2012) (0)
- Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone (2007) (0)
- Conversion of 7[alpha]-hydroxyDHEA into 7-ketoDHEA: Role of type 2 11[beta]-hydroxysteroid dehydrogenase (2012) (0)
- Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone (2003) (0)
- Neuroendocrine control of steroid biosynthesis within the hypothalamus (2007) (0)
- Control of 3β-HSD mRNA and Activity During the Estrous Cycle in the Bovine Ovary (1991) (0)
- Contents, Vol. 35, 1993 (1993) (0)
- [Structure and expression of the genes encoding the enzymes for ovarian and peripheral steroidogenesis]. (1992) (0)
- Probing the active site of reconstituted human placental aromatase [Poster 02] (1987) (0)
- Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules (2005) (0)
- Vasotocin and mesotocin stimulate neurosteroid biosynthesis in the frog brain. Possible involvement of a V1a receptor (2006) (0)
- Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone (2007) (0)
- Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH (2004) (0)
- Production of carbon monoxide by sonication of medium containing glycerol. Effect on cytochrome P-450 reconstituted systems. (1981) (0)
- Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H) (2006) (0)
- Biphenyl derivatives and their use as anti-androgenic (2003) (0)
- Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone (2007) (0)
- Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(H) in an open conformation (2006) (0)
- Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404 (2006) (0)
- Regulation of neurosteroid biosynthesis by the endozepine ODN: Structure–activity relationships and characterization of the receptor (2006) (0)
- Control of neurosteroid biosynthesis by neurotransmitters and neuropeptides (2002) (0)
- Abstract P2-06-03: Specific Transcriptional Response of Four Blockers of Estrogen Receptors on Estrogen-Modulated Genes in ZR-75-1 Breast Cancer Xenografts (2012) (0)
- Role of retinol dehydrogenase 12 (RDH12) in the biosynthesis of 5[alpha]-androstane-3[beta],17[beta]-diol (3[beta]-diol) in the skin (2013) (0)
- Localization of 17 (cid:1) -hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues (2004) (0)
- Pituitary Hormone Regulation of Ovarian 3β-HSD Gene Expression and Activity in the Rat (1991) (0)
- Subject Index Vol. 84, 1999 (1999) (0)
- Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone (2004) (0)
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