Varda Rotter
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Molecular biologist and cancer researcher
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Varda Rotterbiology Degrees
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Biology
Varda Rotter's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
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Why Is Varda Rotter Influential?
(Suggest an Edit or Addition)According to Wikipedia, Varda Rotter is a German-born-Israeli cancer researcher. Biography Varda Rotter attended Bar-Ilan University where she studied microbiology for her bachelor's degree and cellular biology for her master's degree . Rotter attended the Weizmann Institute of Science to receive a doctorate in immunology . After completing her studies, Rotter moved to America and became a part of a cancer research group at the Massachusetts Institute of Technology .
Varda Rotter's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- When mutants gain new powers: news from the mutant p53 field (2009) (1087)
- Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. (2011) (827)
- Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation (1984) (751)
- Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. (2000) (744)
- Mutant p53 gain-of-function in cancer. (2010) (719)
- Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. (1985) (409)
- Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis (1990) (383)
- Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. (2013) (381)
- Nitric oxide-induced cellular stress and p53 activation in chronic inflammation (2002) (344)
- 'Cancer associated fibroblasts'--more than meets the eye. (2013) (314)
- Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene (1984) (266)
- Meth A fibrosarcoma cells express two transforming mutant p53 species. (1988) (261)
- Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues (2012) (259)
- Human p53 gene localized to short arm of chromosome 17 (1986) (227)
- Modulation of the vitamin D3 response by cancer-associated mutant p53. (2010) (224)
- Transcription regulation by mutant p53 (2007) (221)
- Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages. (1994) (210)
- p53-dependent cell cycle control: response to genotoxic stress. (1998) (205)
- Nuclear localization is essential for the activity of p53 protein. (1991) (205)
- p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells (1996) (205)
- The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. (2003) (204)
- Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. (1993) (199)
- c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. (1993) (196)
- Activated p53 suppresses the histone methyltransferase EZH2 gene (2004) (196)
- Molecular basis for heterogeneity of the human p53 protein (1986) (190)
- Regulation of AIF expression by p53 (2006) (187)
- Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. (2007) (182)
- Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells. (1990) (179)
- Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50 (1980) (178)
- Involvement of p53 in cell differentiation and development. (1997) (175)
- Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery (2016) (174)
- Involvement of wild-type p53 in pre-B-cell differentiation in vitro. (1991) (170)
- Introduction: p53 – the first twenty years (1999) (168)
- Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies (2011) (166)
- p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation (2008) (165)
- p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner (2008) (164)
- Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif. (1993) (162)
- Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. (2003) (161)
- Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery (1999) (158)
- Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53 (2001) (157)
- Mutant p53 protein expression interferes with p53-independent apoptotic pathways (1998) (157)
- Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes. (1993) (155)
- Mutant p53 proteins bind DNA abnormally in vitro. (1991) (153)
- p53 is balancing development, differentiation and de-differentiation to assure cancer prevention. (2010) (153)
- TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance (2003) (152)
- Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells (2011) (151)
- Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia. (1989) (150)
- Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells (2010) (149)
- Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis (2009) (149)
- A Fast Signal–Induced Activation of Poly(Adp-Ribose) Polymerase (2000) (147)
- Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function (2004) (143)
- Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins. (1991) (138)
- p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells. (1983) (130)
- Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants (2003) (130)
- p53-dependent Down-regulation of Telomerase Is Mediated by p21waf1* (2004) (128)
- Testicular tissue-specific expression of the p53 suppressor gene. (1993) (126)
- Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy. (2017) (121)
- The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. (2002) (117)
- Immunologically distinct p53 molecules generated by alternative splicing (1986) (114)
- Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences (1984) (112)
- Accumulation of wild‐type p53 protein upon gamma‐irradiation induces a G2 arrest‐dependent immunoglobulin kappa light chain gene expression. (1995) (111)
- The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene. (1993) (111)
- p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. (2001) (109)
- TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model (2011) (107)
- A DNA binding domain is contained in the C-terminus of wild type p53 protein. (1991) (105)
- p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity (2013) (105)
- Regulation of lipid metabolism by p53 – fighting two villains with one sword (2012) (105)
- Inhibition of cell growth mediated by plasmids encoding p53 anti-sense. (1987) (101)
- hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis. (2006) (101)
- Direct involvement of p53 in programmed cell death of oligodendrocytes. (1995) (97)
- p53: The barrier to cancer stem cell formation (2014) (96)
- PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb (1997) (95)
- Expression of p53 in human leukemia and lymphoma. (1986) (94)
- Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. (2003) (94)
- Integrity of the N‐terminal transcription domain of p53 is required for mutant p53 interference with drug‐induced apoptosis (2001) (93)
- Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species (2012) (93)
- Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin. (1999) (91)
- P53 transformation‐related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non‐transformed fibroblasts. (1983) (90)
- p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes (2011) (89)
- Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy (2008) (86)
- Modulated expression of WFDC1 during carcinogenesis and cellular senescence (2008) (86)
- The paradigm of mutant p53-expressing cancer stem cells and drug resistance. (2014) (83)
- Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells (2010) (83)
- Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis (2019) (82)
- Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1. (1988) (80)
- Structural and functional involvement of p53 in BER in vitro and in vivo (2001) (79)
- The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation (2005) (79)
- Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer (2011) (78)
- Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1. (2009) (78)
- Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage. (1993) (77)
- Role of wild type p53 in the G2 phase: regulation of the γirradiation-induced delay and DNA repair (1997) (77)
- Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. (2007) (76)
- Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site (2007) (76)
- p53 on the crossroad between regeneration and cancer (2016) (75)
- Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels. (1996) (75)
- p53 increases experimental metastatic capacity of murine carcinoma cells (1988) (74)
- The role of p53 in base excision repair following genotoxic stress. (2003) (73)
- p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways. (2010) (73)
- Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents (1981) (73)
- Pla2g16 phospholipase mediates gain-of-function activities of mutant p53 (2014) (71)
- Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule (1985) (71)
- Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers (2018) (70)
- p53, a novel regulator of lipid metabolism pathways. (2012) (70)
- Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate (2009) (69)
- Abelson murine leukemia virus-transformed cells that lack p53 protein synthesis express aberrant p53 mRNA species (1984) (69)
- p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production (2013) (68)
- p53 controls low DNA damage-dependent premeiotic checkpoint and facilitates DNA repair during spermatogenesis. (1999) (67)
- Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature (2012) (67)
- Idiotypic immunization induces immunity to mutated p53 and tumor rejection (1998) (66)
- Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation (2009) (65)
- Cancer cells suppress p53 in adjacent fibroblasts (2009) (64)
- Does wild-type p53 play a role in normal cell differentiation? (1994) (64)
- Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type II (2007) (63)
- Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation (2008) (63)
- Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer (2009) (61)
- Involvement of wild-type p53 protein in the cell cycle requires nuclear localization. (1991) (61)
- A novel polymorphism in intron 6 of the human p53 gene: a possible association with cancer predisposition and susceptibility. (1995) (61)
- Mutant p53 gain of function is interwoven into the hallmarks of cancer (2011) (61)
- A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype (2010) (60)
- Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. (2005) (59)
- Expression from the murine p53 promoter is mediated by factor binding to a downstream helix-loop-helix recognition motif. (1991) (59)
- Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53 (2006) (58)
- Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies. (2001) (56)
- Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. (2009) (55)
- Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides (2016) (55)
- Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells. (1996) (55)
- Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. (2013) (54)
- p53 orchestrates between normal differentiation and cancer. (2015) (53)
- On a fundamental structure of gene networks in living cells (2012) (53)
- Deconstruction of p53 functions and regulation (2002) (52)
- Biological and molecular analysis of p53 cellular-encoded tumor antigen. (1985) (49)
- p53 and human malignancies. (1991) (48)
- Increased mitogenic reactivity of normal spleen cells to T lectins induced by thymus humoral factor (THF). (1975) (48)
- p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition (2012) (48)
- p53 and the Viral Connection: Back into the Future ‡ (2018) (46)
- In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene (1985) (45)
- Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction. (2006) (45)
- Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation (2014) (45)
- Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression. (2011) (45)
- DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. (2004) (44)
- Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells. (2012) (44)
- Restoration of cellular immune response by levamisole in patients with Hodgkin's disease. (1975) (43)
- COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis. (1999) (42)
- Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress (1999) (42)
- Principles of signaling pathway modulation for enhancing human naive pluripotency induction (2021) (41)
- p53 is dispensable for apoptosis but controls neurogenesis of mouse dentate gyrus cells following gamma-irradiation. (2001) (41)
- Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis. (2010) (41)
- Chromosomal assignment of the murine gene encoding the transformation-related protein p53 (1984) (41)
- SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63 (2011) (41)
- INHIBITION OF TUMOR GROWTH IN SYNGENEIC CHIMERIC MICE MEDIATED BY A DEPLETION OF SUPPRESSOR T CELLS (1975) (40)
- ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters. (2011) (40)
- Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma. (1999) (39)
- Thymus cell population exerting a regulatory function in the immune response of mice to polyvinyl pyrrolidone. (1974) (39)
- Modulation of the Vitamin D 3 Response by Cancer-Associated Mutant p 53 (38)
- Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation. (2016) (38)
- p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss (2010) (37)
- The human 1‐8D gene (IFITM2) is a novel p53 independent pro‐apoptotic gene (2009) (35)
- p53 mutations in matched primary and metastatic human tumors (1995) (35)
- Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein (1993) (35)
- Studies on the effect of a thymic humoral factor on differentiation of thymus‐derived lymphocytes (1973) (35)
- p63 Attenuates Epithelial to Mesenchymal Potential in an Experimental Prostate Cell Model (2013) (34)
- Resistance to hydrocortisone conferred upon thymocytes by a thymic humoral factor (1974) (34)
- In search of the functions of normal p53 protein. (1993) (33)
- Post-translational regulation of p53 function through 20S proteasome-mediated cleavage (2017) (33)
- p53, a novel regulator of lipid metabolism pathways (2012) (32)
- Tissue-specific p53 expression in the nervous system. (1999) (32)
- Amyloid-β precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress (2007) (32)
- Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta (2013) (31)
- Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line. (1992) (31)
- p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53 (2000) (31)
- The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele (2014) (31)
- Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth inhibitory agents: possible relation to high bcl-2/bax ratio? (2000) (31)
- Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. (2007) (30)
- Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C‐terminal domain of p53 that recognizes damaged DNA (2000) (30)
- A novel transcript encoded within the 10-kb first intron of the human p53 tumor suppressor gene (D17S2179E) is induced during differentiation of myeloid leukemia cells. (1996) (29)
- Diverse p53/DNA binding modes expand the repertoire of p53 response elements (2017) (29)
- Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension (2007) (29)
- Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop (2011) (29)
- Activation of p53 protein by telomeric (TTAGGG)n repeats. (2001) (28)
- Liver and Steroid Hormones—Can a Touch of p53 Make a Difference? (2019) (28)
- The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells (1997) (28)
- Convergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach (2011) (28)
- The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts (2003) (27)
- Transcriptional control of the proliferation cluster by the tumor suppressor p53. (2010) (27)
- p53 and its mutants on the slippery road from stemness to carcinogenesis. (2017) (27)
- Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy (2018) (26)
- STUDIES ON CHARACTERIZATION OF THE LYMPHOID TARGET CELL FOR ACTIVITY OF A THYMUS HUMORAL FACTOR (1973) (26)
- BIOCHEMICAL AND BIOLOGICAL PROPERTIES OF THF IN ANIMAL AND HUMAN MODELS (1979) (26)
- Cellular events and the pattern of p53 protein expression following cyclophosphamide-initiated cell death in various organs of developing embryo. (1999) (26)
- Molecular alterations in the TP53 gene of peripheral blood cells of patients with chronic myeloid leukemia (1998) (25)
- SEVERE DISSEMINATED ADENOVIRUS INFECTION SUCCESSFULLY TREATED WITH A THYMIC HUMORAL FACTOR, THF (1977) (25)
- Targeting mutant p53 for cancer therapy (2016) (25)
- Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form. (1995) (25)
- Hypoxia‐dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter (2004) (24)
- The DNA binding activity of wild type p53 is modulated by blocking its various antigenic epitopes. (1995) (24)
- Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits (2016) (23)
- Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ (2014) (23)
- p53 mediates density‐dependent growth arrest (2004) (23)
- p53 is a regulator of macrophage differentiation (2004) (23)
- p53 controls hPar1 function and expression (2008) (23)
- p53 balances between tissue hierarchy and anarchy (2019) (22)
- An insight into the life of p53: a protein coping with many functions! Review of the 9th p53 Workshop, Crete, May 9-13, 1998. (1998) (21)
- The DNA binding regulatory domain of p53: see the C. (1997) (21)
- Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult. (1999) (21)
- The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells. (1996) (20)
- Thymic hormone (THF) therapy in immunosuppressed children with lymphoproliferative neoplasia and generalized varicella. (1977) (20)
- Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation (2015) (19)
- A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells. (2018) (19)
- Variation in antigenic determinants of p53 transformation-related protein obtained from various species. (1983) (19)
- p53 in liver pathologies—taking the good with the bad (2014) (19)
- Falkor, a novel cell growth regulator isolated by a functional genetic screen (2002) (19)
- High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry (2017) (19)
- The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis (2001) (19)
- Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis. (1998) (18)
- Altered Subcellular Localization of p53 in Estrogen-Dependent and Estrogen-Independent Breast Cancer Cells (2002) (18)
- p 53-dependent Down-regulation of Telomerase Is Mediated by p 21 waf 1 * (2004) (18)
- Mutant p53—a potential player in shaping the tumor–stroma crosstalk (2019) (18)
- Discovery of Novel Proteasome Inhibitors Using a High-Content Cell-Based Screening System (2009) (18)
- Pooled analysis of p53 mutations in hematological malignancies (1998) (18)
- Induction of Apoptosis and p53 Expression in Immature Thymocytes by Direct Interaction with Thymic Epithelial Cells (1996) (17)
- Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. (2011) (17)
- Prevalence of Autoantibodies to the p53 Protein in Autoimmune Hepatitis (2002) (17)
- Monoclonal antibody to a DNA‐binding domain of p53 mimics charge structure of DNA: anti‐idiotypes to the anti‐p53 antibody are anti‐DNA (2004) (17)
- The presence of p53 transformation‐related protein in Ab‐MuLV transformed cells is required for their development into lethal tumors in mice (1983) (17)
- Two promoters that map to 5'-sequences of the human p53 gene are differentially regulated during terminal differentiation of human myeloid leukemic cells. (1989) (17)
- Myocardin in Tumor Suppression and Myofibroblast Differentiation (2007) (16)
- Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation. (1997) (15)
- Alternatively spliced mRNA transcripts encoding the extracellular domain of the FSH receptor gene. Expression in the mouse ovary during the ovulatory cycle. (1998) (15)
- Mutant p53 oncogenicity - dominant-negative or gain-of-function? (2020) (15)
- Cancer research, a field on the verge of a paradigm shift? (2012) (15)
- The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells (2014) (15)
- Identification of gene networks associated with erythroid differentiation. (2009) (14)
- Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells (2016) (14)
- Response of human lymphocytes to PHA and Con A, dependent on and regulated by THF, a thymic hormone. (1976) (14)
- Did experimental biology die? Lessons from 30 years of p53 research. (2009) (14)
- Role of thymic hormone (THF) and of a thymic plasma recirculating factor (TPRF) in the modulation of human lymphocyte response to PHA and Con A. (1979) (14)
- The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy. (2009) (14)
- TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response (2016) (14)
- DNA-binding activity of wild-type p53 protein is mediated by the central part of the molecule and controlled by its C terminus. (1998) (13)
- Histochemical studies of progressive p53 mutations during colonic carcinogenesis in Sprague-Dawley rats induced by N-methyl-N-nitro-nitrosoguanidine or azoxymethane. (1994) (13)
- Expression of wild-type and mutant p53 proteins by recombinant vaccinia viruses (1992) (13)
- Role of L-alanine in the response of human lymphocytes to PHA and Con A. (1979) (12)
- Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase (2009) (12)
- Major deletions in the gene encoding the p 53 tumor antigen cause lack of p 53 expression in HL-60 cells ( human p 53 cDNA / c-myc amplification ) (12)
- THE EFFECT OF THF IN LYMPHOPROLIFERATIVE AND MYELOPROLIFERATIVE DISEASES IN CHILDREN * (1979) (12)
- Differential expression of metastasis‐associated cell surface glycoproteins and mRNA in a murine large cell lymphoma (1986) (12)
- DNA binding and 3′–5′ exonuclease activity in the murine alternatively-spliced p53 protein (2002) (11)
- Thymus extracts induce differentiation of thymus derived cells. (1973) (10)
- Spot-1, a novel NLS-binding protein that interacts with p53 through a domain encoded by p(CA)n repeats. (1995) (10)
- Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner (2018) (9)
- RHAMM in the complex p53 cell cycle network (2008) (9)
- Abstract 2465: Gene expression, phenotypic and karyotypic analyses of stepwise prostate carcinogenesisin vitro (2010) (9)
- Can an iPS cell secure its genomic fidelity? (2011) (9)
- p53: balancing tumour suppression and implications for the clinic. (2009) (8)
- Anti‐p53 Autoantibodies in Colon Cancer Patients (1997) (8)
- Unleash the wild type: Restoration of p53 suppressive activity in skin cancer (2011) (8)
- p53 tumor suppressor gene expression in the mouse ovary during an artificially induced ovulatory cycle. (1999) (8)
- Single chain antibody against the common epitope of mutant p53 restores wild‐type activity to mutant p53 protein (2005) (8)
- Genetic Alterations in p 53 , INK 4 A , and HRas Genes along Defined Stages of Malignant Transformation (2005) (7)
- Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. (1994) (7)
- p 53 Controls Low DNA Damage-dependent Premeiotic Checkpoint and Facilitates DNA Repair during Spermatogenesis 1 (1999) (7)
- Modulates Base Excision Repair Activity in a Cell Cycle-specific Manner after Genotoxic Stress 1 (2000) (7)
- Immunohistochemical detection of p53 protein expression in HPV-induced condyloma acuminatum. (1995) (7)
- Elimination of suppressor T-cells in mice undergoing a graft-versus-host reaction expressed by increased response to polyvinylpyrrolidone (PVP). (1975) (6)
- The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity. (2009) (6)
- The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop. (2001) (6)
- P53 gene mutation in a T-acute lymphoblastic leukemia cell line (loucy) with t(16:20) and 5q- chromosomal aberrations. (1998) (6)
- In vitro allogeneic response of human lymphocytes dependent upon dialyzable plasma components and a thymic hormone, THF. (1978) (6)
- Effect of thymic hormone on the response of different lymphoid cell populations to T mitogens. (1977) (5)
- Expression of p 53 in Human Leukemia and Lymphoma (2005) (5)
- in Cancer Cells α Tumor Necrosis Factor B Activation by κ Mutant p 53 Enhances Nuclear Factor (2007) (4)
- Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 (DOI: 10.1016/j.ccr.2009.11.025) (2010) (4)
- An intragenic deletion of nuclear localization signal-1 of p53 tumor suppressor gene results in loss of apoptosis in murine fibroblasts. (1999) (4)
- The Oncogenic Activity of p53 Mutants (2005) (4)
- The murine telomerase catalytic subunit shares the PAb‐240 mutant specific epitope of the p53 protein (2003) (4)
- Induced expression from the Moloney murine leukemia virus long terminal repeat during differentiation of human myeloid cells is mediated through its transcriptional enhancer (1989) (3)
- The expression of transformation-related protein p53 and p53-containing mRNA in murine RAW117 large cell lymphoma cells of differing metastatic potential (1984) (3)
- Mutant p53 attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species (2013) (3)
- Expression of p53 in differentiation and apoptosis and its deregulation in tumor cell. (1997) (3)
- Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia (2021) (3)
- Expression ofabl and other oncogenes is independent of metastatic potential in Abelson virus-transformed malignant murine large cell lymphoma (1985) (3)
- Tumor-Promoting Circuits That Regulate a Cancer-Related Chemokine Cluster: Dominance of Inflammatory Mediators Over Oncogenic Alterations (2012) (3)
- p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production (2013) (3)
- Chromosomal mapping of the murine c-abl proto-oncogene by in situ hybridization. (1990) (3)
- Visual barcodes for clonal-multiplexing of live microscopy-based assays (2022) (3)
- Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi‐directional loss of heterozygosity in bone marrow progenitors (2017) (2)
- Beyond tumor suppression: p53 controls blastocyst implantation (2011) (2)
- Mutations in the tetramerization domain of p53: More than just keeping monomers apart (2009) (2)
- Retraction: Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function. (2019) (2)
- Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus-transformed malignant murine large cell lymphoma. (1985) (2)
- Kinetics of proliferation of splenic macrophage precursor cells during the early primary immune response. (1972) (2)
- Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability (2022) (1)
- Influenza A virus and p53: Can the Two Walk Together? A Commentary on “p53 and the Viral Connection: Back into the Future” (2020) (1)
- Differential Responses of Macrophage Precursors and Antibody Forming Cells to Immunization (1971) (1)
- Abstract 1290: The ability of the transcription factor p63 to induce selected gene expression modules associated with mesenchymal to epithelial transition of prostate cells (2012) (1)
- Proceedings: Increased mitogenic reactivity of lymphoid cells to T lectins induced by thymus humoral factor. (1975) (1)
- Biochemistry and Molecular Biology Raw117 Large Cell Lymphoma (1986) (1)
- Analysis of Transcriptional Regulatory Regions of The Human p53 Gene in Human Cells Using An EBV-Derived Shuttle Vector (1989) (1)
- Corrigendum to ‘p53 balances between tissue hierarchy and anarchy’ (2019) (1)
- Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis (2023) (1)
- Mutant p53 modulates the signal of hepatocyte growth factor (HGF) to endow cancer cells with drug resistance (2016) (1)
- Endothelial Matrix Assembly during Capillary Morphogenesis (2014) (1)
- The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif. (2019) (1)
- Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia (2022) (1)
- detoxifying enzymes and promotes the survival of cells with high ROS levels. (2012) (1)
- The p53 suppressor gene plays a role in cell differentiation (1993) (1)
- cancer cells: projection on the hematologic cell lineages Structure and function of p53 in normal cells and their aberrations in (2011) (0)
- Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner (2018) (0)
- A POTENTIAL TUMOUR SUPPRESSIVE ROLE FOR THE NOVEL PROSTATE BASAL CELL MARKER TSC-22 IN PROSTATE CANCER (2006) (0)
- BIOCHEMISTRY AND MOLECULAR BIOLOGY RAWl17 LARGE CELL LYMPHOMA (1986) (0)
- DKFZ-MOST Cooperation in Cancer Research (2016) (0)
- 39 THE EFFECT OF THE IN IMMUNOSUPPRESSED CHILDREN WITH LYMPHO PROLIFERATIVE DISEASES (1979) (0)
- Abstract 2329: Restriction of androgen receptor and target gene expression (2014) (0)
- Association of Wild-Type P53 with Cell Differentiation: Induction of Pre-b Cell Maturation in Vitro (1993) (0)
- Isolation andCharacterization ofDNA Sequences ThatAre Specifically BoundbyWild-Type p53Protein (1993) (0)
- PCA/DD3, A PROTEIN-BINDING NON-CODING RNA WITH ONCOGENIC PROPERTIES (2006) (0)
- The tumor supressor p 53-our cell gurdian (2009) (0)
- Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy (2018) (0)
- p53 alterations in breast tumors in patients of Brazil (1996) (0)
- Searching for the function of the p53 suppressor gene in normal cells (1994) (0)
- 42: The mutant p53-cancer stem cells and drug resistance paradigm (2014) (0)
- Abstract 154: Genome-wide profiling of histone and DNA methylation in prostate cells during EMT and malignant transformation (2010) (0)
- Correction: Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides (2019) (0)
- Corrigendum to: The role of p53 in base excision repair following genotoxic stress. (2021) (0)
- Abstract B17: Stepwise prostate carcinogenesisin vitroculture (2009) (0)
- p53 in liver pathologies—taking the good with the bad (2014) (0)
- Major deletions in the gene encodi) lack of p53 expression in HL-60 ce) (human p53 cDNA/c-myc amplification) (2016) (0)
- Abstract 1820: TP63 regulation of epithelial to mesenchymal transition in an experimental prostate cell model. (2013) (0)
- Same stem cells but different: Isogenic embryonic stem cells harboring different p53 mutants (2011) (0)
- THYMIC HORMONES WORKSHOP SUMMARY (1979) (0)
- Depletion of suppressor T cells in syngeneic chimeric mice. (1976) (0)
- Mutant p53 hinges between epithelial-mesenchymal transition and cancer stem cells (2018) (0)
- p53Increases Experimental Metastatic Capacity ofMurine Carcinoma Cells (1988) (0)
- Mutant p53 leads to enrichment of cancer stem cells that display ESC expression signature (2018) (0)
- Abstract 3089: The role of p63 regulation during epithelial to mesenchymal transition (EMT) and subsequent accumulation of malignant features of primary immortalized prostate cells (2011) (0)
- Immunophenotypes and Gene Rearrangements of the T-Cell Receptor in Two Patients with a Large Granular Lymphocyte Disorder. (1991) (0)
- Mutant p53 exerts its gain of function through activation of the NF-κB pathway (2005) (0)
- Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R (2009) (0)
- chronic myelogenous leukemia (see comments) Rearrangements in the p53 gene in Philadelphia chromosome positive (2011) (0)
- Abstract 5288: Development of lead mutant-p53 reactivating peptides towards clinical application (2022) (0)
- High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry (2017) (0)
- The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells (2014) (0)
- peptide inhibitors to mediate stress responses (2005) (0)
- Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A (2009) (0)
- Human p53 core domain with hot spot mutation R249S (III) (2009) (0)
- Abstract 2023: Complex in vitro and in vivo prostate cancer models for the PREDECT consortium (2014) (0)
- Abelson MurineLeukemia Virus-Induced TumorsElicit Antibodies Against a HostCellProtein, P50 (1980) (0)
- The Murine C (cid:57) -Terminally Alternatively Spliced Form of p53 Induces Attenuated Apoptosis in Myeloid Cells (1997) (0)
- TRANSFORMING GROWTH FACTOR STIMULATED CLONE 22 (TSC-22): POTENTIAL TUMOR SUPPRESSIVE ROLE IN PROSTATE CANCER AND NOVEL PROSTATE BASAL CELL MARKER (2006) (0)
- The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice (2018) (0)
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