Vassilis Pachnis
#119,993
Most Influential Person Now
Senior Group Leader at the Francis Crick Institute in London
Why Is Vassilis Pachnis Influential?
(Suggest an Edit or Addition)According to Wikipedia, Vassilis Pachnis is a Senior Group Leader in the Development and Homeostasis of the Nervous System Laboratory at the Francis Crick Institute. Education Pachnis was born and raised in Greece. He graduated from the University of Athens in 1980 where he studied Medicine. From 1980 until 1986 he worked for his PhD in the laboratory of Shirley Tilghman at the University of Pennsylvania and the Fox Chase Cancer Center where his research identified and characterised the H19 gene.
Vassilis Pachnis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret (1994) (1604)
- Expression of the c-ret proto-oncogene during mouse embryogenesis. (1993) (842)
- GDNF signalling through the Ret receptor tyrosine kinase (1996) (821)
- Functional receptor for GDNF encoded by the c-ret proto-oncogene (1996) (816)
- The Medial Ganglionic Eminence Gives Rise to a Population of Early Neurons in the Developing Cerebral Cortex (1999) (756)
- Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies (2007) (507)
- Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. (1996) (412)
- Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. (1997) (381)
- Spatial Genetic Patterning of the Embryonic Neuroepithelium Generates GABAergic Interneuron Diversity in the Adult Cortex (2007) (380)
- Lhx6 Activity Is Required for the Normal Migration and Specification of Cortical Interneuron Subtypes (2007) (354)
- Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. (2002) (333)
- Glial origin of mesenchymal stem cells in a tooth model system (2014) (327)
- Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. (1996) (323)
- Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. (1998) (314)
- Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. (2011) (305)
- Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. (1984) (282)
- Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. (1999) (267)
- Tyrosine kinase receptor RET is a key regulator of Peyer’s Patch organogenesis (2007) (258)
- Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. (2001) (257)
- Enteric Nervous System Progenitors Are Coordinately Controlled by the G Protein-Coupled Receptor EDNRB and the Receptor Tyrosine Kinase RET (2003) (252)
- The structure and expression of a novel gene activated in early mouse embryogenesis. (1988) (240)
- Fgf-8 determines rostral-caudal polarity in the first branchial arch. (1999) (236)
- Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria (2015) (236)
- Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity. (2000) (206)
- Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures (2003) (202)
- Galanin regulates prolactin release and lactotroph proliferation. (1998) (202)
- The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development (2009) (201)
- Mox2 is a component of the genetic hierarchy controlling limb muscle development (1999) (196)
- The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites (2003) (184)
- Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system (2015) (171)
- Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut (2004) (170)
- Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus1 (2008) (169)
- Parasympathetic neurons originate from nerve-associated peripheral glial progenitors (2014) (167)
- Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling (2006) (152)
- The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System (2016) (147)
- Neuronal programming by microbiota regulates intestinal physiology (2020) (144)
- The enteric nervous system. (2012) (143)
- Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. (1999) (142)
- Expression of the cret proto-oncogene during mouse embryogenesis (1996) (135)
- Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep (2017) (133)
- Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. (2006) (130)
- Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. (2004) (123)
- Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. (2015) (117)
- Two regulatory domains flank the mouse H19 gene (1988) (117)
- Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. (2006) (116)
- Lineage-dependent spatial and functional organization of the mammalian enteric nervous system (2017) (115)
- LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons (2009) (114)
- Development of the mammalian enteric nervous system. (1999) (107)
- Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons (2012) (103)
- Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells (2006) (103)
- RET proto-oncogene is important for the development of respiratory CO2 sensitivity. (1997) (102)
- White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. (2016) (100)
- Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7‐deficient mice (2005) (92)
- Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform (2005) (91)
- Development of the intrinsic and extrinsic innervation of the gut. (2016) (91)
- Enteric nervous system development: Recent progress and future challenges (2009) (90)
- Neuroimmune regulation during intestinal development and homeostasis (2017) (89)
- Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems (2012) (84)
- Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. (2015) (84)
- Immune and nervous systems: more than just a superficial similarity? (2009) (83)
- Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior (2003) (76)
- The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis (1997) (75)
- Planar cell polarity genes control the connectivity of enteric neurons. (2013) (75)
- Prospective Identification and Isolation of Enteric Nervous System Progenitors Using Sox2 (2010) (75)
- Hepatic stellate cells do not derive from the neural crest. (2006) (75)
- Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells. (1990) (73)
- Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex (2017) (72)
- The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition (2009) (70)
- Lhx8 regulates primordial follicle activation and postnatal folliculogenesis (2015) (67)
- Analysis of neural crest–derived clones reveals novel aspects of facial development (2016) (65)
- Expression of the RET proto-oncogene in human embryos. (1998) (65)
- Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System (2017) (65)
- RET‐deficient mice: an animal model for Hirschsprung's disease and renal agenesis (1995) (61)
- The LIM Homeodomain Protein Lhx6 Regulates Maturation of Interneurons and Network Excitability in the Mammalian Cortex (2012) (61)
- The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. (2000) (59)
- Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species (2008) (55)
- Geminin Regulates Cortical Progenitor Proliferation and Differentiation (2011) (55)
- Targeted Disruption of the Murine Galanin Gene a (1998) (54)
- Development of the enteric nervous system: bringing together cells, signals and genes (2009) (52)
- Transcriptional Regulation of Cortical Interneuron Development (2007) (51)
- Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret -/- mice. (1996) (48)
- Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. (2009) (45)
- Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. (2012) (45)
- Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum (2012) (45)
- The effect of the ret- mutation on the normal development of the central and parasympathetic nervous systems. (1996) (43)
- Ret deficiency in mice impairs the development of A5 and A6 neurons and the functional maturation of the respiratory rhythm (2005) (42)
- Regulation of intestinal immunity and tissue repair by enteric glia (2021) (42)
- Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors (2001) (42)
- Isolation and characterization of a chicken homolog of the c-ret proto-oncogene. (1995) (41)
- Meox1Cre: A mouse line expressing Cre recombinase in somitic mesoderm (2005) (39)
- The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system (2015) (38)
- A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity (2016) (37)
- Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells (2010) (35)
- III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system. (1998) (35)
- Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons (2014) (33)
- Structurally defined signaling in neuro‐glia units in the enteric nervous system (2019) (30)
- Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System (2016) (28)
- The influence of Hox genes and three intercellular signalling pathways on enteric neuromuscular development (2004) (24)
- Ventilatory responses to hypercapnia and hypoxia in heterozygous c-ret newborn mice (2002) (20)
- Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (1995) (20)
- Life without geminin (2010) (19)
- Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis (2008) (18)
- RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo (2012) (18)
- Getting to the guts of enteric nervous system development (2006) (17)
- Enteric glia as a source of neural progenitors in adult zebrafish (2020) (15)
- “Enteric glia as a source of neural progenitors in adult zebrafish” (2020) (13)
- Sexually dimorphic effects of the Lhx7 null mutation on forebrain cholinergic function (2006) (11)
- Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis (2016) (10)
- Enteric Nervous System: lessons from neurogenesis for reverse engineering and disease modelling and treatment. (2020) (9)
- Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis. (2016) (9)
- Homeostatic Regulation of Interneuron Apoptosis During Cortical Development (2018) (9)
- Travelling within the fetal gut: simple rules for an arduous journey (2014) (7)
- Neural Injury, Repair, and Adaptation in the GI Tract III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system (1998) (7)
- The role of enteric glia in intestinal immunity (2022) (5)
- Sex differences in water maze performance and cortical neurotrophin levels of LHX7 null mutant mice (2009) (5)
- Neuronal programming by microbiota enables environmental regulation of intestinal motility (2019) (3)
- MTG8 interacts with LHX6 to specify cortical interneuron subtype identity (2022) (3)
- Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep (2017) (3)
- Molecular profiling of enteric nervous system cell lineages (2022) (3)
- Luminal nutrients activate distinct patterns in submucosal and myenteric neurons in the mouse small intestine (2021) (2)
- Multiple Roles of Ret Signalling During Enteric Neurogenesis (2022) (2)
- Linking neurons to immunity: Lessons from Hydra (2020) (2)
- Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains. (2019) (2)
- Enteric glia bring fresh WNT to the intestinal stem cell niche. (2022) (1)
- Travelling within the fetal gut: simple rules for an arduous journey (2014) (1)
- A branching model of cell fate decisions in the enteric nervous system (2022) (1)
- Author response: Enteric glia as a source of neural progenitors in adult zebrafish (2020) (0)
- Neural crest derived mesenchymal cells form a network in the adult thymus (2007) (0)
- Regulation of neural diversity by Ascl1 indicates strong intrinsic control of subtype specification in enteric progenitors during early bowel development (2017) (0)
- Changes in the enteric nervous system and surrounding cells during ageing (2016) (0)
- 14-P001 SOX2 expression provides a means to identify and isolate ENS progenitors (2009) (0)
- Title Sonic hedgehog regulates the proliferation , differentiation , andmigration of enteric neural crest cells in gut (2004) (0)
- DEFECTIVE ENTERIC NERVOUS SYSTEM STEM CELL FUNCTION IN THE PATHOGENESIS OF HIRSCHSPRUNG'S DISEASE?: OP2-06 (2005) (0)
- GEMININ IS ESSENTIAL FOR THE GENERATION AND DIFFERENTIATION OF ENTERIC NERVOUS SYSTEM PROGENITOR CELLS (2011) (0)
- Novel regulatory genes during neuronal diversification in the developing enteric nervous system (2017) (0)
- Lhx8 regulates primordial follicle activation and postnatal folliculogenesis (2015) (0)
- Sox6, a regulatory gene in the specification of gastric dopaminergic neurons (2017) (0)
- III. Role Of the RET signal transduction pathway in development of the mammalian enteric nervous system. (1998) (0)
- Dendritic inhibition defects lead to epilepsy in Lhx6 hypomorphic mutant mice (2010) (0)
- Neuronal programming by microbiota regulates intestinal physiology (2020) (0)
- S-4-4 Role of Ret/GDNF in branching morphogenesis of the ureteric bud (2002) (0)
- Mature T Cells Proliferation of Thymocytes and Differential Geminin Requirement for (2010) (0)
- Use of genetic tools to perform in vivo analysis of glia in the enteric nervous system (2013) (0)
- IDENTIFICATION AND CHARACTERIZATION OF THE H19 LOCUS WHICH IS UNDER THE CONTROL OF THE MURINE RAF AND RIF GENES (1987) (0)
- 12-P010 Role of LIM homedomain transcription factors LHX7 and ISL1 in the specification of mouse basal forebrain cholinergic neurons (2009) (0)
- OrganogenesisProgram/Abstract # 361Expression profiling the developing mammalian enteric nervous system identifies novel markers and candidate Hirschsprung disease genes (2007) (0)
- Studies into the raf and Rif genes in the mouse. (1985) (0)
- LHX7 is required in mouse striatal cholinergic interneurons to maintain neuronal subtype identity (2010) (0)
- TISSUE-SPECIFIC STEM CELLS Geminin Regulates Cortical Progenitor Proliferation and Differentiation (2011) (0)
- Transfer of Yeast Artificial Chromosomes into Cultured Cells: A New Method for Manipulating the Mammalian Genome (1992) (0)
- 21-P027 Clonal deletion of RET using mosaic analysis with double markers (MADM) in the enteric nervous system (2009) (0)
- Modelling transcriptomics data of the developing enteric nervous system (2017) (0)
- regulates primordial follicle activation and postnatal folliculogenesis. (2015) (0)
- Activity-Dependent Control Of Inhibitory Interneuron Number In The Mammalian Cortex (2017) (0)
- 17-P015 Temporal regulation of neurogenesis in the enteric nervous system (2009) (0)
- WITHDRAWN: Expression profiling the developing mammalian enteric nervous system identifies novel markers and candidate Hirschsprung disease genes (2007) (0)
- Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis (2016) (0)
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