Vijay K Kuchroo

Q: What Schools Are Affiliated With Vijay K Kuchroo

Vijay K Kuchroo is affiliated with the following schools: Harvard University, University of Lausanne, University of Queensland, University of Bristol, University of Oxford, Albert Einstein College of Medicine, Augusta University, University of Pittsburgh, Kagawa University, Massachusetts General Hospital

Vijay K Kuchroo's AcademicInfluence.com Rankings

Vijay K Kuchroo

Biology

#3530

World Rank

#5389

Historical Rank

Immunology

#146

World Rank

#153

Historical Rank

Neuroscience

#335

World Rank

#351

Historical Rank

biology Degrees

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Biology

Vijay K Kuchroo's Degrees

PhD Immunology University of Oxford

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Vijay K Kuchroo's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells (2006) (6954)
IL-17 and Th17 Cells. (2009) (4659)
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression (2007) (2163)
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. (1994) (2128)
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells (2007) (1932)
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy (1995) (1863)
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009) (1740)
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity (2005) (1716)
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (2010) (1605)
Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants (2014) (1487)
TH-17 cells in the circle of immunity and autoimmunity (2007) (1485)
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease (2002) (1403)
Interleukin-17 and type 17 helper T cells. (2009) (1384)
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. (2016) (1300)
Induction and effector functions of TH17 cells (2008) (1185)
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients (2010) (1124)
Induction and molecular signature of pathogenic TH17 cells (2012) (956)
IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells (2008) (950)
IL-12 family cytokines: immunological playmakers (2012) (949)
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007) (860)
Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 (2013) (846)
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007) (809)
Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis (2003) (785)
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection (2010) (743)
Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes1 (2009) (726)
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells (2009) (713)
Th17: the third member of the effector T cell trilogy. (2007) (706)
Peripheral deletion of antigen-reactive T cells in oral tolerance (1995) (684)
Tim-3 inhibits T helper type 1–mediated auto- and alloimmune responses and promotes immunological tolerance (2003) (681)
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. (2004) (635)
Dynamic regulatory network controlling Th17 cell differentiation (2013) (626)
Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells (2007) (622)
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance (2003) (609)
CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis (2007) (607)
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. (2014) (606)
IL-21 and TGF-β are required for differentiation of human TH17 cells (2008) (602)
Control of TH17 cells occurs in the Small Intestine (2011) (600)
IL-10 is critical in the regulation of automimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice (1998) (542)
Regulatory T cells: recommendations to simplify the nomenclature (2013) (536)
Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression1 (2008) (531)
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. (2011) (529)
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis (2004) (525)
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells (2008) (518)
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family (2001) (508)
IL-17-producing human peripheral regulatory T cells retain suppressive function. (2009) (501)
Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells1 (2000) (495)
Tim‐3 and its role in regulating anti‐tumor immunity (2017) (489)
Th17 cells: effector T cells with inflammatory properties. (2007) (479)
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity (2015) (460)
Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells (2009) (459)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2014) (455)
CD28/B7 costimulation: a review. (1998) (454)
Proinflammatory T helper type 17 cells are effective B-cell helpers (2010) (444)
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. (2008) (415)
Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions (2011) (411)
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. (2011) (410)
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation (2017) (407)
Role of Th1 and Th17 cells in organ-specific autoimmunity. (2008) (403)
The TIM gene family: emerging roles in immunity and disease (2003) (402)
T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. (2002) (397)
Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells1 (2009) (396)
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions. (2015) (392)
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. (2004) (381)
Robust tumor immunity to melanoma mediated by interleukin 9 (2012) (377)
TIGIT predominantly regulates the immune response via regulatory T cells. (2015) (374)
TIM3 comes of age as an inhibitory receptor (2019) (369)
T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt (2011) (364)
Protective Autoimmunity Is a Physiological Response to CNS Trauma (2001) (349)
Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells1 (2009) (348)
TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation (2005) (348)
The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells (2010) (343)
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells (2009) (341)
The TIGIT/CD226 Axis Regulates Human T Cell Function (2012) (337)
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD‐1−CD8+ Tumor‐Infiltrating T Cells (2019) (334)
CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis1 (2007) (334)
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein (2007) (321)
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. (2012) (317)
Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. (2006) (314)
TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines (2009) (308)
Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. (1993) (302)
High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice (2000) (291)
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway (2009) (291)
Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. (1996) (287)
Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade (2014) (280)
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells (2016) (275)
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39 (2013) (274)
Effector and Regulatory T‐cell Subsets in Autoimmunity and Tissue Inflammation (2010) (270)
CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. (2007) (269)
Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen‐Specific Regulatory T Cells (2007) (268)
Induction and transcriptional regulation of the co-inhibitory gene module in T cells (2018) (266)
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity (2015) (265)
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. (2013) (263)
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation (2015) (261)
Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 (2012) (260)
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. (2015) (252)
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. (2010) (251)
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer (2013) (249)
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. (2014) (249)
Th17 cells: from precursors to players in inflammation and infection. (2009) (244)
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. (2004) (243)
A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. (1994) (242)
Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis (1999) (242)
The many faces of Th17 cells. (2011) (241)
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses (2015) (240)
Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. (2004) (240)
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis (2003) (240)
Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells (2010) (238)
Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. (1997) (232)
The costimulatory role of TIM molecules (2009) (232)
Dysregulated T cell expression of TIM3 in multiple sclerosis (2006) (231)
T Cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-Derived Mononuclear Cells in Multiple Sclerosis1 (2004) (229)
Emerging Tim-3 functions in antimicrobial and tumor immunity. (2011) (228)
CD226 Gly307Ser association with multiple autoimmune diseases (2009) (227)
KIM-1-mediated phagocytosis reduces acute injury to the kidney. (2015) (225)
Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. (2004) (223)
Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-β T Cell-Transgenic Mice1 (2007) (222)
Aiolos promotes TH17 differentiation by directly silencing Il2 expression (2012) (218)
Using EAE to better understand principles of immune function and autoimmune pathology. (2013) (215)
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion (2012) (213)
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. (2004) (207)
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia (2018) (199)
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. (2015) (198)
The TIM gene family regulates autoimmune and allergic diseases. (2005) (198)
Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways (2011) (195)
Phagocytosis imprints heterogeneity in tissue-resident macrophages (2017) (194)
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. (2014) (193)
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice (2010) (188)
IL-9 Induces Differentiation of TH17 Cells and Enhances Function of FoxP3+Natural Regulatory T Cells (2009) (186)
Tim3 binding to galectin-9 stimulates antimicrobial immunity (2010) (180)
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity (2015) (174)
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block (2005) (171)
Peripheral deletion of antigen-reactive T cells in oral tolerance (1995) (170)
Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. (2000) (169)
PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines. (2013) (169)
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function (2016) (168)
TGF-β Induces IL-9 Production from Human Th17 Cells (2010) (167)
IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation (2013) (165)
Predictors of responses to immune checkpoint blockade in advanced melanoma (2017) (162)
Type 1 regulatory T cells (Tr1) in autoimmunity. (2011) (162)
B7-2 (CD86) is essential for the development of IL-4-producing T cells. (1996) (161)
The Sjögren’s Syndrome-Associated Autoantigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death1 (2006) (159)
Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation (2015) (155)
Induction of pathogenic Th 17 cells by inducible salt sensing kinase SGK 1 (2013) (154)
Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions1 (2008) (153)
Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6–lpr/lpr Mice (2010) (150)
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense (2019) (149)
IL-12– and IL-23–induced T helper cell subsets (2005) (149)
Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis1 (2008) (148)
Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. (1992) (146)
Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage. (1992) (145)
QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2 (1999) (145)
An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction (2015) (145)
Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. (1996) (145)
Specific T Regulatory Cells Display Broad Suppressive Functions against Experimental Allergic Encephalomyelitis upon Activation with Cognate Antigen1 (2005) (142)
New roles for TIM family members in immune regulation (2008) (140)
IL-4, IL-10, IL-13, and TGF-β from an Altered Peptide Ligand-Specific Th2 Cell Clone Down-Regulate Adoptive Transfer of Experimental Autoimmune Encephalomyelitis (2000) (139)
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function (2007) (138)
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. (2011) (138)
TIM-3 and its regulatory role in immune responses. (2011) (138)
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans (1994) (136)
Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. (1996) (133)
Th17 cells. (2009) (133)
T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis (1994) (133)
Interplay Between Effector Th17 and Regulatory T Cells (2008) (129)
Tim-2 regulates T helper type 2 responses and autoimmunity (2005) (128)
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. (2008) (127)
Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice (2012) (127)
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. (2012) (126)
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses (2019) (125)
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection (2016) (123)
TGF-β signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis (2008) (122)
Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression (2012) (120)
Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. (2001) (117)
TIM-4 Expressed on APCs Induces T Cell Expansion and Survival1 (2008) (116)
TIM family of genes in immunity and tolerance. (2006) (115)
TCR usage in human and experimental demyelinating disease. (1996) (115)
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. (2019) (111)
Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread (2014) (111)
T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation (2013) (111)
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity (2021) (110)
Spatially organized multicellular immune hubs in human colorectal cancer (2021) (109)
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. (2019) (109)
Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis1 (2005) (109)
IL-23 Receptor Regulates Unconventional IL-17–Producing T Cells That Control Bacterial Infections (2010) (108)
Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3− effector T cells that produce interleukins 9 and 10 (2008) (108)
T‐bet, a Th1 transcription factor regulates the expression of Tim‐3 (2010) (105)
Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts. (2007) (104)
Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation (2015) (103)
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (2011) (102)
Interferon-α Induces Up-regulation and Nuclear Translocation of the Ro52 Autoantigen as Detected by a Panel of Novel Ro52-specific Monoclonal Antibodies (2008) (100)
Inhibition of CTLA-4 Function by the Regulatory Subunit of Serine/Threonine Phosphatase 2A1 (2002) (99)
Immune checkpoints in central nervous system autoimmunity (2012) (98)
Tim-3, Lag-3, and TIGIT. (2017) (97)
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity (2020) (96)
Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity (2018) (96)
Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. (2006) (95)
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation (1995) (93)
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. (1997) (91)
T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses (2011) (90)
IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet (2013) (90)
Th3 Cells in Peripheral Tolerance. II. TGF-β-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity1 (2007) (89)
Dysregulation of immune homeostasis in autoimmune diseases (2012) (89)
Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation (2017) (87)
Bat3 Protects T cell Responses by Repressing Tim-3-Mediated Exhaustion and Death (2012) (87)
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. (2016) (86)
The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance1 (2005) (86)
The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. (1992) (84)
Mapping and identification of autoimmunity genes. (2000) (83)
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation (2021) (83)
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production (2002) (83)
OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells (2008) (83)
T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice (2014) (82)
CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions1 (2005) (81)
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling (2013) (81)
Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function (2018) (80)
Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance. (2019) (79)
Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IAs) Tetramers1 (2003) (78)
High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model1 (2005) (77)
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 (2012) (77)
Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice1 (2009) (76)
Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. (1999) (76)
Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis (2017) (75)
How Cytokine Networks Fuel Inflammation: Interleukin-17 and a tale of two autoimmune diseases (2013) (73)
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells (2018) (73)
IL-4-Deficient and Transgenic Mice Demonstrated by Studies of IL-10- and Autoimmune Encephalomyelitis as IL-10 Is Critical in the Regulation of (1998) (72)
Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein (1997) (71)
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization (2016) (71)
Polyamine metabolism is a central determinant of helper T cell lineage fidelity (2021) (71)
Effector T cell differentiation: are master regulators of effector T cells still the masters? (2015) (69)
TIMs: central regulators of immune responses (2008) (69)
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. (1997) (69)
The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis 1 (2004) (68)
T‐cell immunoglobulin and mucin domain 4 (TIM‐4) signaling in innate immune‐mediated liver ischemia‐reperfusion injury (2014) (65)
Immunology of neuromyelitis optica: a T cell–B cell collaboration (2013) (65)
TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. (2014) (64)
Th 1 , Th 17 , and Th 9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes 1 (2009) (64)
Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. (2020) (63)
Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. (2001) (63)
Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. (2008) (63)
Coinhibitory receptors and CD8 T cell exhaustion in chronic infections (2014) (63)
SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells (2018) (62)
B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. (1999) (62)
High Ro52 expression in spontaneous and UV-induced cutaneous inflammation. (2009) (62)
Response to Comment on “CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions” (2006) (61)
Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. (2008) (61)
Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy (2018) (61)
Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells. (2010) (61)
Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen (1998) (61)
A Transgenic Model of Central Nervous System Autoimmunity Mediated by CD4+ and CD8+ T and B Cells (2012) (60)
B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism (1999) (59)
IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling (2015) (57)
Suppressor T cells: some answers but more questions. (1992) (57)
Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. (1991) (54)
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. (2012) (54)
IL-10 Plays an Important Role in the Homeostatic Regulation of the Autoreactive Repertoire in Naive Mice1 (2004) (54)
IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation (2009) (53)
Disease‐related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis (2004) (53)
Targeting latency-associated peptide promotes antitumor immunity (2017) (52)
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. (2021) (52)
Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content (2018) (51)
Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells1 (2000) (51)
Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. (2011) (51)
H1N1 vaccination in Sjögren’s syndrome triggers polyclonal B cell activation and promotes autoantibody production (2017) (50)
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. (2002) (50)
Metallothioneins negatively regulate IL-27–induced type 1 regulatory T-cell differentiation (2013) (49)
Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. (1999) (49)
Tim‐1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells (2011) (49)
Inheritance of susceptibility to experimental autoimmune encephalomyelitis (1996) (48)
IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis. (2003) (48)
Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. (2002) (48)
Faculty Opinions recommendation of Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. (2009) (47)
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system (2016) (46)
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. (2004) (46)
IL-17 Blockade in Psoriasis (2016) (46)
T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function. (1991) (46)
Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors (2013) (45)
Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. (2014) (44)
The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program (2017) (44)
Characterization of MHC‐ and TCR‐binding residues of the myelin oligodendrocyte glycoprotein 38–51 peptide (2004) (44)
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity (2021) (44)
Oct1 and OCA-B are selectively required for CD4 memory T cell function (2015) (44)
Anti-Ro52 monoclonal antibodies specific for amino acid 200–239, but not other Ro52 epitopes, induce congenital heart block in a rat model (2011) (44)
Transcription factor T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the RORγt gene (2010) (42)
Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 (2018) (42)
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. (2004) (42)
Podoplanin negatively regulates CD4+ effector T cell responses. (2015) (42)
Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. (2015) (41)
Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7‐1/B7‐2‐deficient mice (2003) (41)
Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. (2004) (40)
Reduced Self-Reactivity of an Autoreactive T Cell After Activation with Cross-reactive Non–Self-Ligand (2002) (40)
Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity (2016) (39)
Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma (2018) (39)
Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung (2014) (39)
Emerging new roles of Th17 cells (2012) (38)
Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules (2004) (38)
Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. (2005) (37)
Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. (2019) (37)
The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation (2014) (36)
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis. (2010) (35)
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block (2010) (35)
Cutting Edge: CD94/NKG2 Is Expressed on Th1 But Not Th2 Cells and Costimulates Th1 Effector Functions1 (2002) (35)
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. (2014) (35)
Expression of Self-antigen in the Thymus (2003) (33)
T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice (1994) (32)
Minireview: Autoimmune responses to myelin proteolipid protein (1994) (32)
TIM Family Proteins Promote the Lysosomal Degradation of the Nuclear Receptor NUR77 (2012) (32)
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2016) (32)
Tim-1 Signaling Substitutes for Conventional Signal 1 and Requires Costimulation to Induce T Cell Proliferation1 (2009) (32)
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis (2018) (32)
IκB Kinase 2/β Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis1 (2007) (32)
Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity. (2020) (31)
Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90 (2012) (31)
Structurally Derived Mutations Define Congenital Heart Block‐Related Epitopes Within the 200–239 Amino Acid Stretch of the Ro52 Protein (2005) (30)
Structural Organization and Zn2+-dependent Subdomain Interactions Involving Autoantigenic Epitopes in the Ring-B-box-Coiled-coil (RBCC) Region of Ro52* (2005) (30)
Role of Th1 and Th2 cells in neurologic disorders. (1996) (30)
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets (2020) (30)
Th 17 cells : from precursors to players in inflammation and infection (2009) (30)
Differentiation and Characterization of Tr1 Cells (2016) (29)
Induction and molecular signature of pathogenic T[subscript H]17 cells (2012) (29)
Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species (2006) (29)
The cytotoxic process of CD4 Th1 clones. (1992) (29)
T Cell–Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A–Mediated Epidermal Hyperplasia (2016) (29)
IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. (2015) (28)
TGF-β Signaling Initiated in Dendritic Cells Instructs Suppressive Effects on Th17 Differentiation at the Site of Neuroinflammation (2014) (28)
The Yin and Yang of Follicular Helper T Cells (2009) (28)
Overexpression of the CTLA-4 Isoform Lacking Exons 2 and 3 Causes Autoimmunity (2012) (27)
The TIGIT / CD 226 Axis Regulates Human (2012) (27)
Podoplanin is a negative regulator of Th17 inflammation. (2017) (26)
Defining the functional states of Th17 cells (2015) (26)
Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment (2015) (25)
Combinatorial prediction of marker panels from single-cell transcriptomic data (2019) (25)
Protect the killer: CTLs need defenses against the tumor (2002) (25)
Expression and characterization of TCA3: a murine inflammatory protein. (1990) (24)
TIM-4 Identifies IFN-γ–Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection (2017) (24)
Mechanisms of Disease Interleukin-17 and Type 17 Helper T Cells (2009) (24)
Functional Th1 Cells Are Required for Surgical Adhesion Formation in a Murine Model1 (2008) (23)
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3 (2018) (23)
Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation (2018) (23)
Good guys gone bad: exTreg cells promote autoimmune arthritis (2014) (23)
Combinatorial prediction of marker panels from single‐cell transcriptomic data (2019) (23)
Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells (2000) (23)
Epigenetic and transcriptional mechanisms for the regulation of IL-10. (2019) (22)
Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity. (1989) (21)
Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. (2020) (21)
Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b+CD11c− APC1 (2008) (21)
New pieces in the puzzle: How does interferon‐β really work in multiple sclerosis? (2009) (21)
Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. (2007) (20)
Genetic background determines the requirement for B7 costimulation in induction of autoimmunity (2002) (19)
Immunology: Fast and feel good? (2003) (19)
Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. (2014) (19)
Copolymer effects on microglia and T cells in the central nervous system of humanized mice (2005) (19)
Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells (2018) (19)
TIM 3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection (2016) (19)
Relationships between antigen-specific helper and inducer suppressor T cell hybridomas. (1990) (19)
Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression. (1988) (19)
Correction: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction (2015) (18)
The Autoimmune Diabetes Locus Idd9 Regulates Development of Type 1 Diabetes by Affecting the Homing of Islet-Specific T Cells1 (2006) (18)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2020) (18)
A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks. (1989) (17)
Cytokines and Autoimmune Diseases (2001) (17)
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function. (2021) (17)
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. (2007) (17)
An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells. (2005) (16)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2022) (16)
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion (2021) (16)
Characterization of the phenotype and function of CD8+, α / β+ NKT cells from tumor‐bearing mice that show a natural killer cell activity and lyse multiple tumortargets (2001) (16)
OR.100. PD-L1 Regulates the Development, Maintenance and Function of Induced-regulatory T Cells (2009) (16)
Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation. (2001) (16)
Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function. (1990) (15)
A chimeric T cell receptor with super-signaling properties. (2004) (15)
Chronic stress physically spares but functionally impairs innate-like invariant T cells (2020) (14)
Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells (2020) (14)
Prior exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis: T-cell repertoire engaged by the autoantigen determines clinical outcome (1996) (13)
Cytosolic Phospholipase A2α Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs (2011) (13)
Role of Co-stimulatory Molecules in T Helper Cell Differentiation. (2019) (13)
In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity (2020) (13)
Regulation of T-Cell Immunity by T-Cell Immunoglobulin and Mucin Domain Proteins (2007) (12)
T Cell Tolerance Induced by Cross-Reactive TCR Ligands Can Be Broken by Superagonist Resulting in Anti-Inflammatory T Cell Cytokine Production1 (2005) (11)
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases * (2022) (11)
Mechanisms of TIGIT-driven immune suppression in cancer (2014) (11)
Systems-based approaches to study immunometabolism (2022) (11)
Human disease mutations highlight the inhibitory function of TIM-3 (2018) (11)
T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction. (1995) (11)
Unexpected Targets and Triggers of Autoimmunity (2014) (11)
Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. (2001) (10)
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice (2015) (10)
Tim Protein Structures Reveal a Unique Face for Ligand Binding (2007) (10)
Co-expression of Tim-3 and PD-1 Identifies a CD8+T-Cell Exhaustion Phenotype in Mice with Disseminated Acute Myelogenous Leukemia (2011) (10)
Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. (1988) (10)
Expression of CD3-associated antigen-binding receptors on suppressor T cells. (1988) (10)
Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity. (1995) (9)
Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion (2021) (9)
Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. (2013) (9)
Cutting Edge: CD4CD25 Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis 1 (2005) (9)
Antigen-driven regulation of experimental autoimmune encephalomyelitis. (1998) (9)
Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics. (2019) (9)
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool. (2022) (9)
Antigen Specific Suppressor Cells, Receptors, and Factors (1989) (8)
Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia (2018) (8)
Gene-environment interaction in induction of autoimmunity. (2011) (8)
Ezh2 lines up the chromatin in T regulatory cells. (2015) (8)
A monoclonal antibody raised to tumor-specific T cell-derived suppressor factors also recognizes T suppressor inducer factors of the 4-hydroxy-3-nitrophenyl acetyl hapten suppressor network. (1987) (8)
A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. (2015) (8)
Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses. (2020) (8)
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function (2022) (7)
Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation (2017) (7)
Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection” (2014) (7)
Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis (2022) (7)
Tim-3 mediates T cell trogocytosis to limit antitumor immunity (2022) (7)
Horn cancer in an intact bull (1980) (7)
Response to Comment on “Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-κB-Dependent Cytokine Expression in Fibroblasts” (2009) (7)
How does Epstein-Barr virus trigger MS? (2022) (7)
SGK 1 Governs the Reciprocal Development of Th 17 and Regulatory T Cells (2018) (6)
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling. (2022) (6)
Pathogenic versus protective repertoires in autoimmune disease: Tuning the balance (1998) (6)
Requirements for suppressor cell activation. Role of accessory cells. (1989) (6)
Antigen-driven regulation of experimental autoimmune encephalomyelitis (1998) (6)
T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity (2020) (6)
A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs (2012) (6)
Th1 and Th2 cells in health and disease (1996) (6)
Physical attraction of Th9 cells is skin deep. (2015) (6)
Genetics of experimental autoimmune encephalomyelitis. (1999) (6)
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium (2020) (6)
Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway (2020) (6)
Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H‐2s congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes (2004) (5)
TH17 cell heterogeneity and its role in tissue inflammation (2023) (5)
IL-18: throwing off the shackles to boost anti-tumor immunity (2020) (5)
The Origin and Regulation of Autopathogenic T Cells (2001) (5)
Microenvironment and Immunology CD 8 þ T Cells Speci fi c for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1 (2012) (5)
Cytokines in Autoimmune Disease (2002) (4)
KIM-1 Mediated Tubular Fatty Acid Uptake Leads to Progressive Diabetic Kidney Disease (2020) (4)
Microenvironment and Immunology PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen – Speci fi c CD 8 þ T Cells Induced by Melanoma Vaccines (2014) (4)
Value added: neural progenitor cells suppress inflammation and autoimmunity. (2011) (4)
Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cells (2019) (4)
Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression (2013) (4)
Encephalomyelitis Experimental Autoimmune Clone DownRegulate Adoptive Transfer of Altered Peptide Ligand-Specific Th 2 Cell from an β IL-4 , IL-10 , IL-13 , and TGF-and Mary Collins (2000) (4)
Polyamine metabolism regulates the T cell epigenome through hypusination (2020) (4)
FoxP3+Tim-3+ Tregs are site-specific suppressors supporting tumor growth by influencing the functional phenotype of tumor-infiltrating lymphocytes (46.5) (2012) (4)
T helper cells modulate intestinal stem cell renewal and differentiation (2017) (4)
Metabolic regulation and function of T helper cells in neuroinflammation (2022) (4)
'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. (1994) (4)
Th17 Cells in Autoimmune Inflammation and Demyelination in the Central Nervous System (2013) (3)
Author Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity (2020) (3)
Sa.15. The TIM-3 and its Ligand Mediated Signaling Negatively Regulates T Helper Type 1 Immunity (2006) (3)
Thymus derived rosette forming cell counts and lymphocyte response to phytohaemagglutinin in animals affected with squamous cell carcinoma of horn. (1981) (3)
Understanding suppressor cells: where have we gone wrong? (1988) (3)
Abstract 5410: Tim-3 expression and function in natural killer cells from metastatic melanoma patients (2012) (3)
Myelin-specific Regulatory T Cells Accumulate in the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation (2007) (3)
Defining the contribution of T cell exhaustion to failed immunity during TB (2016) (3)
IRF-1 is a key transcriptional regulator of Tr1 differentiation (P1135) (2013) (3)
An agenda to advance research in MDS: A TOP 10 Priority List from the first international workshop in MDS (iwMDS). (2022) (3)
Th17 cell differentiation increases aquaporin-3 expression, which is further increased by treatment with NaCl. (2016) (3)
The role of immune deviation in regulation of experimental autoimmune encephalomyelitis and multiple sclerosis. In immunointervention in autoimmunity by Th1/Th2 regulation (1997) (2)
Trial watch: Targeting IL-17A shows broad promise in autoimmune diseases (2010) (2)
B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease (2022) (2)
IL-23 receptor deficiency prevents the development of lupus nephritis in B6/lpr mice (96.20) (2010) (2)
Regulates Proliferation and Cell Death Autoantigen Ro 52 Is an E 3 Ligase That The Sjögren ' s Syndrome-Associated Kuchroo and (2006) (2)
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer (2021) (2)
for Activation of CD28-Deficient T Cells Intercellular Adhesion Molecule 1 Is Critical (2000) (2)
The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states (2022) (2)
Constitutive co-stimulation by B cells is sufficient to trigger T cell-driven autoimmune disease (2010) (2)
Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells (2018) (2)
Droplet-based forward genetic screening of astrocyte–microglia cross-talk (2023) (2)
Fine tuning of the immune response by the Aryl Hydrocarbon Receptor (2013) (2)
Functional Th 1 Cells Are Required for Surgical Adhesion Formation in a Murine Model 1 (2008) (2)
Down-regulation of suppressor cell induction. (1988) (2)
Lab management: insights for the new investigator (2006) (2)
Selecting killers: the line between life and death (2000) (2)
Deficiency in IL23R Accelerates Wound Healing in Experimental Colitis (2011) (2)
An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment (2019) (2)
T Cells and Their Subsets in Autoimmunity (2014) (2)
Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium. (1990) (2)
Experimental allergic encephalitis in B7-deficient C57BL/6 mice (1998) (2)
MHC genes determine fetal susceptibility in a rat model of congenital heart block (2012) (2)
Heterogeneous T cell receptor (TcR) Vβs of acute experimental allergic encephalomyelitis (EAE) induced with a myelin proteolipid protein (PLP) peptide and peptide-specific T cell clones (1991) (1)
Tim-1 Mucin Domain-Mutant Mice Display Exacerbated Atherosclerosis (2019) (1)
TIM-1 Plays a Crucial Role in the Expansion of Autopathogneic T-Cells and Regulation of Autoimmunity (2006) (1)
Expression of CD 3-associated antigen-binding receptors on suppressor T cells ( CD 3 expression / T-ceil receptors ) (1)
Receptor Expression Signaling and Inhibiting IL-6 and IL-23 -Driven Smad3 b by Enhancing TGF-Cells and Inhibits Development of Th17 Cells Regulatory T + Retinoic Acid Increases Foxp3 (2008) (1)
OR.56. The Sjögren's Syndrome Associated Autoantigen Ro52 Is a Ring-Dependent E3 Ligase That Regulates Cell Death (2006) (1)
Abstract A10: A distinct gene module for T cell dysfunction uncoupled from T cell activation and controlled by metallothioneins (2017) (1)
Fine tuning of the immune response by the Aryl Hydrocarbon Receptor (2013) (1)
OR.57. IL-4 Inhibits TGF-β-induced Foxp3+T Cells and, Together with TGF-β, Generates IL-9+IL-10+Foxp3-Effector T Cells (2009) (1)
Myelin proteolipid protein specific TH2 clones suppress autoimmune encephalomyelitis (1994) (1)
Cell Function The TIGIT/CD226 Axis Regulates Human T (1)
Experimental Autoimmune Encephalomyelitis (2001) (1)
Phenotype in Mice with Disseminated Acute Myelogenous Leukemia Running title: PD-1+Tim-3+ CD8+T-cells induced by AML are dysfunctional (2011) (1)
Autoantigenic PLP peptides identified by MHC binding (1994) (1)
Receptor Tim-3 Expressed on Innate Immune Cells Promotion of Tissue Inflammation by the Immune (2008) (1)
The role of the T cell receptor alpha chain in antigen-specific immune suppression. (1993) (1)
From T H 1/T H 2 Paradigm to T H 17 Cells: Le Roi Est Mort, Vive Le Roi (2011) (1)
Abstract 5407: The upregulation of BTLA and PD-1 defines a novel subset of dysfunctional tumor antigen-specific CD8+ T cells (2012) (1)
T Cells Induced by Melanoma Vaccines + CD 8 Specific − PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen (2014) (1)
Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia (2018) (1)
Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex. (1990) (1)
DUBA-UBR5 axis: other than transactivation (2015) (1)
PD-1 and Tim-3 regulate the expansion of vaccine-induced tumor antigen-specific CD8+ T cells in patients with advanced melanoma (VAC3P.944) (2014) (1)
Myelin basic protein (MBP)-specific TGFβ-secreting CD4+ T-cell clones derived from orally tolerized animals suppress experimental autoimmune encephalomyelitis (1994) (1)
Induced-Tolerogenic Dendritic Cells That Promote Tolerance And De Novo Differentiation Of Regulatory T Cells (2012) (1)
Antigenic similarity between squamous cell carcinoma of horn (horn cancer) and normal bovine foetal tissues (1979) (1)
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19. (2023) (1)
Dysregulation of the TIM-3-Galectin-9 Pathway in Type I Diabetic T Cells (2007) (1)
OR.98. IL-23 Receptor (IL-23R) GFP Reporter Mice Reveal New Populations of IL-17-producing and IL-23-responsive Cells (2008) (1)
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut (2023) (1)
Killers come to the rescue (2002) (1)
Tim-3 expression and function in natural killer cells from advanced melanoma patients. (2012) (1)
Preface Emerging new roles of Th17 cells (2012) (1)
NEGATIVE IMMUNE REGULATOR TIM-3 IS OVEREXPRESSED ON INTRAHEPATIC AND PERIPHERAL T CELLS IN CHRONIC HCV INFECTION AND ITS BLOCKADE RESCUES DYSFUNCTIONAL CD4+AND CD8+T CELLS (2009) (1)
Going beyond a whack‐a‐mole game: A systems biology approach to immune tolerance (2018) (0)
Susceptibility in Congenital Heart Block MHC-Encoded Genes Determine Pathogenic Antibodies and Fetal Maternal MHC Regulates Generation of (2010) (0)
Strategies and rationale for the design of antigen analogs to study the T cell receptor (1997) (0)
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium (2021) (0)
Autoimmunity Lacking Exons 2 and 3 Causes Overexpression of the CTLA-4 Isoform (2011) (0)
Th17 and Th22 Cells (2016) (0)
Cell Expansion and Survival TIM-4 Expressed on APCs Induces T (2010) (0)
HTAPP_Dissociation of human primary colorectal cancer resection specimens into single cell suspension for single cell RNA-seq v2 (2021) (0)
Sa.102. Discovery and Characterization of Novel Human TIM-3 Splice Variants (2008) (0)
Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells (2022) (0)
896 Oncolytic herpes simplex virus immuno-virotherapy in combination with tigit immune checkpoint blockade to treat glioblastoma (2022) (0)
IL-27 acts on DCs to suppress CNS autoimmunity by inducing CD39 expression (2014) (0)
Time for TIM-3: Beyond Immune Checkpoint Inhibition This symposium took place on 19 th November 2020, as part of the virtual European Hematology Association (EHA)–Scientific Working Group (SWG) Scientific Meeting on Immunotherapy for Hematological Disorders (2021) (0)
interferon The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and (2013) (0)
Defining the functional states of Th17 cells The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2015) (0)
Faculty Opinions recommendation of A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. (2002) (0)
Encephalomyelitis Experimental Autoimmune Suppressive Monocytes inhiLy-6 C + CD 11 b (2007) (0)
Defining the functional states of Th17 cells [version 1; peer review: 3 approved] (2022) (0)
Transcriptional regulation of IL-10 in T helper cells (2019) (0)
Faculty Opinions recommendation of Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). (2015) (0)
Introduction to the Special Issue: Immuno-oncology. (2021) (0)
The protective effect of the NOD.Idd3 genetic interval is associated with enhanced regulatory T cell function and IL-10 production (B37) (2007) (0)
964 Dynamic immune landscapes during melanoma progression reveal a role for endogenous opioids in driving T cell dysfunction (2022) (0)
Promotion of proinflammatory Th1 and Th17 responses by Tim‐1 expressed on dendritic cells (2008) (0)
Th17 / Treg (SY2-1) Chairpersons: Shimon Sakaguchi, Daniel Cua (2010) (0)
Regulatory Factors Tripartite-Motif 21 Is Controlled by IFN Expression of the Immune Regulator (2013) (0)
with Cognate Antigen Allergic Encephalomyelitis upon Activation Suppressive Functions against Experimental Specific T Regulatory Cells Display Broad (2005) (0)
Abstract A26: Modeling the ovarian cancer immune response and tumor microenvironment (2020) (0)
Tim-3/Tim-3L Pathway as a Target for Restoring Effector Functions in Exhausted CD8 Lymphocytes in Tumors (2010) (0)
Tim-3 is expressed by a majority of NK cells at periphery but not at tumor site in patients with advanced melanoma (TUM2P.919) (2014) (0)
A gene module driving co-inhibitory receptors expression on T cells (2017) (0)
Movie S2. Confocal Time-Lapse Imaging of DC Motility in LN Slices from WT BM → Ub-GFP Mice (2012) (0)
Autoimmune Response and Immune Tolerance (2007) (0)
Chemical inhibition of the ROR{gamma}t-dependent transcriptional network in Th17 cells (P5163) (2013) (0)
Proliferationto Induce T Cell Conventional Signal 1 and Requires Tim-1 Signaling Substitutes for (2010) (0)
Abstract IA02: Next targets for immune checkpoint blockade in melanoma (2020) (0)
CD4+FoxP3+ Tregs are activated by injury (2008) (0)
Endogenous glucocorticoid signaling regulates effector differentiation and development of dysfunction in CD8 + T cells in the tumor microenvironment (2020) (0)
T Cells + of CD4 Costimulation and Regulates Differentiation (ICOS) Expression Is Enhanced by CD28 Mouse Inducible Costimulatory Molecule (2000) (0)
Human disease mutations highlight the inhibitory function of TIM-3 (2018) (0)
NFIL3 and Ets1 co-regulate a cluster of genes, including Tim-3, that is associated with T cell tolerance (2016) (0)
Movie S6. Time-Lapse Imaging Shows the Interaction of Clec1b−/− DCs with WT FRCs Cultured in 3D Matrix (2012) (0)
THU0032 Ccr6+cd4+ t cells drive antigen-induced arthritis via the il-23r pathway (2018) (0)
A second encephalitogenic PLP epitope for SJL mice (1993) (0)
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity (2020) (0)
08.14 IL-23 receptor signalling is critical in normal bone remodelling and influences osteoclast activity in vitro and t cell-driven inflammatory bone damage in vivo (2017) (0)
Regulatory T cells demonstrate an injury-specific recall response (2009) (0)
Sa.43. Identification of the Specific Sjögren-syndrome Related Maternal Ro52 Autoantibodies that Induce Heart Block in the Fetus During Pregnancy (2008) (0)
OR.42. Constitutive Expression of the Costimulatory Molecule CD70 by Non-antigen Specific B Cells is Sufficient to Drive T Cell-driven Autoimmune Disease (2009) (0)
Identiﬁcation of genetic loci associated with paralysis, inﬂammation and weight loss in mouse experimental autoimmune encephalomyelitis (2001) (0)
Sclerosis Fluid-Derived Mononuclear Cells in Multiple and Th 2 Cells and in Cerebrospinal Are Differentially Expressed on Human Th 1 Molecule-3 ( TIM-3 ) and TIM-1 (2004) (0)
Immunotherapy in Neuroimmunologic Diseases (1998) (0)
Absence of STAT1 Signaling IL-27 Induces Th17 Differentiation in the (2015) (0)
Cell-specific metabolic models reveal novel metabolic regulators of Th17 pathogenicity: from single-cell RNA-Seq to actionable metabolic targets (2018) (0)
Compositions et methodes associees a tim-3, molecule de surface cellulaire specifique a th1 (2003) (0)
Su.32. Myelin-specific Regulatory T Cells Accumulatein the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation [abstract only] (2007) (0)
OR.25. Promotion of Proinflammatory Th1 and Th17 Responses by Tim-1 Expressed on Dendritic Cells (2008) (0)
High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13) (2012) (0)
OR.31. Human TIM-3 Regulates Th1 and Th17 Cytokines (2009) (0)
The regulatory role of naturally occurring CTLA-4 splice variants:the suppressive function of short splice variant 1/4 WT CTLA-4 (B91) (2007) (0)
Single-cell RNA-seq identifies the neuropeptide NMU as a novel regulator of ILC2 function (2018) (0)
Faculty Opinions recommendation of Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (2010) (0)
Overexpression of the CTLA-4 Isoform (2011) (0)
Targeting PD-1 and Tim-3 pathways to reverse tumor antigen-specific CD4+ T cell dysfunction in patients with advanced melanoma (66.1) (2011) (0)
of Low Dose Oral Tolerance Costimulation Is Required for the Induction B7.2 (CD86) But Not B7.1 (CD80) (1999) (0)
Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells (2018) (0)
University of Birmingham Podoplanin negatively regulates CD4+ effector T cell responses (2014) (0)
Effector Functions Th1 But Not Th2 Cells and Costimulates Th1 Cutting Edge: CD94/NKG2 Is Expressed on (2002) (0)
Induced-tolerogenic Dendritic Cells promote tolerance and de novo differentiation of regulatory T cells (65.6) (2012) (0)
Glucocorticoid signaling regulates CD8+T cell responses in cancer (2019) (0)
OR.44. Incomplete Freund's Adjuvant Skews the Balance Between TH17 and Foxp3+ T-regs and Induces Antigen-specific Tolerance Due to the Lack of IL-6 Induction (2008) (0)
SP0150 Th17 cells drive and regulate tissue inflammation (2017) (0)
Abstract B085: Combining transcriptomic profiling and genome engineering to dissect regulation of tumor immunology (2016) (0)
Transcriptional Regulation of IL-10-producing Regulatory Type 1 Cells (2010) (0)
SY-23 Human CD4+CD25high natural Tregs and Th17 effector cells are related (2008) (0)
Ligands de tim-3 et methodes associees (2004) (0)
Maresin-1 regulates type 2 innate lymphoid cells and promotes generation of regulatory T cells to limit allergic inflammation (HYP2P.336) (2015) (0)
HTAPP_Dissociation of human primary colorectal cancer resection specimens into single cell suspension for single cell RNA-seq v1 (2019) (0)
tRNA-m1A modification: a translational checkpoint for T cell expansion (2022) (0)
EXTH-61. MODULATION OF THE IL-27 RECEPTOR SIGNALING PATHWAY IN GLIOBLASTOMA AND ONCOLYTIC VIROTHERAPY (2021) (0)
The upregulation of the inhibitory receptors BTLA and PD-1 defines a novel subset of dysfunctional tumor antigen-specific CD8+ T cells (127.19) (2012) (0)
Erratum: IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ Foxp3− effector T cells (2009) (0)
Diff erential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and eff ector function (2007) (0)
Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis (2017) (0)
046 Dynamic regulatory network controlling Tr1 cell development in epithelial tissue inflammation (2017) (0)
Heterogeneity of T cell clones specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) (1991) (0)
Faculty Opinions recommendation of Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. (2015) (0)
Lung Inflammation Cell Activation and Promote Resolution of T Cells To Limit Type 2 Innate Lymphoid Cutting Edge: Maresin-1 Engages Regulatory (2014) (0)
Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis. (2022) (0)
The Diabetes Susceptibility LocusIdd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis (2004) (0)
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells (2018) (0)
Correction: Figure 5. (2005) (0)
Melanoma progression is associated with NK cell exhaustion (2014) (0)
Movie S7. Time-Lapse Imaging Shows the Interaction of WT DCs with Pdpn−/− FRCs Cultured in 3D Matrix (2012) (0)
TIM-1 is a novel trafficking receptor controlling T cell recruitment in the CNS and induction of experimental autoimmune encephalomyelitis (2014) (0)
OR.36. Bat3 is a Negative Regulator of Tim-3-mediated Th1 Cell Death (2009) (0)
The Role of the T Cell Receptor α Chain in Antigen‐Specific Immune Suppression (1993) (0)
OR.107. TIM-1 Plays a Crucial Role in the Expansion of Autopathogneic T-Cells and Regulation of Autoimmunity [abstract only] (2006) (0)
and Caspase-3 Activation Macrophages by Regulating TNFR Signaling Promotes Antimicrobial Immunity in β IL-1 (2013) (0)
PhenotypesEncephalomyelitis with Different Pathological Experimental Autoimmune Th1, Th17, and Th9 Effector Cells Induce (2009) (0)
the Development of Mucosal Tolerance The ICOS Molecule Plays a Crucial Role in (2005) (0)
Chemical inhibition of the RORγt-dependent transcriptional network in Th17 cells (P5163) (2013) (0)
Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells (2018) (0)
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3 (2018) (0)
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function (2022) (0)
Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling (2021) (0)
Author Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity (2020) (0)
TIM3 comes of age as an inhibitory receptor (2019) (0)
087 Molecular and cellular mechanisms of tolerogenic signature induction in CD4+ T cells by apoptotic cells (2019) (0)
Sa.107. Mice Overexpressing the Truncated 1/4 CTLA-4 Isoform Have Hyperactive T Cells and Accumulate Memory Cells Without Developing Spontaneous Autoimmune Disease (2008) (0)
Transcript of open discussion (1997) (0)
Signal 1 and Requires Costimulation to Tim-1 Signaling Substitutes for Conventional (2009) (0)
A new spontaneous mouse model for human Devic's disease. (2005) (0)
Crystal structure of the human TIM-3 with bound Calcium (2018) (0)
Critical role of the transcription factors IRF 1 and BATF in preparing the chromatin landscape during Type 1 regulatory cell differentiation (2018) (0)
Tumour associated antigens in bovine horn cancer. (1982) (0)
Cross-Reactive Environmental Antigen Encephalomyelitis by T Cells Primed with a the Induction of Experimental Autoimmune Expansion by Self Antigen Is Necessary for (1998) (0)
by IL-10 Expression Signature in Th Cells Functionally Defined Galectin-1 Triggers an Immunoregulatory (2012) (0)
Tim3/Galectin-9 interactions regulate innate and adaptive immunity to Mycobacterium tuberculosis (70.6) (2012) (0)
Tim-1 expressed on dendritic cells enhances effector T cell responses and inhibits development and function of regulatory T cells (99.9) (2009) (0)
Silencing Nociceptor Neur ons Reduces Allergic Airway Inflammation Highlights (2015) (0)
Movie S4. Time-Lapse Imaging Shows DCs Approaching Branched FRCs in 3D Matrix (2012) (0)
Expression in Fibroblasts''B-Dependent Cytokine k TRIM21/Ro52 in NF-Study Reveals a Nonredundant Role for Response to Comment on ''Gene Disruption (2009) (0)
Analysis of Autoreactive T-Cells in Type I Diabetes (2006) (0)
This information is current as Abrogated within the Cystic Fibrosis Lung Gram-Negative Bacterial Killing: An Effect Involved in Neutrophil-Mediated Galectin-9 Signaling through TIM-3 Is (2014) (0)
194 Interleukin-23 Receptor Signaling on CD4+ T Cells Is Required for Colitis Mediated by Interleukin-10 Receptor-Deficient Innate Immune Cells (2016) (0)
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses (2019) (0)
Myelin specific regulatory T cells expand from naturally occurring regulatory T cells and accumulate in the CNS during EAE (128.8) (2007) (0)
II Molecules Antigens Presented by Different MHC Class Cross-Reactive TCR Responses to Self (2004) (0)
Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells (2023) (0)
Journal club (2008) (0)
Unexpected Targets and Triggers of Autoimmunity (2014) (0)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2021) (0)
Novel synthetic amino acid copolymers suppress MBP 85-99-induced EAE in humanised double-transgenic mice through different effects on T cell responses (2004) (0)
QS379. Injury Activates and Expands Regulatory T Cells (2008) (0)
List of Contributors (2020) (0)
Forum on Th17 cells (2009) (0)
TFR-derived Fibrinogen-like Protein 2 regulates production of autoantibodies and induction of systemic autoimmunity (2020) (0)
Activation and expansion of FoxP3+ Tregs after injury (2008) (0)
IL-17 IL-23 Receptor Regulates Unconventional (2010) (0)
3071 – HEALTHY AND MALIGNANT HEMATOPOIETIC STEM CELLS ACT AS IMMUNOREGULATORY ANTIGEN PRESENTING CELLS (2021) (0)
Cell-Transgenic Mice T β Cells by Th 3 Cells Derived from TGF-Induction of Foxp 3-Positive Regulatory T Th 3 Cells in Peripheral Tolerance (2006) (0)
Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS). (2023) (0)
This information is current as Promote Tumor and Allograft Rejection Proinflammatory B Effector 1 Cells That Expressing − γ TIM-4 Identifies IFN (2017) (0)
Balance in Humans (Th1/Th17)/Anti-Inflammatory (Th2) Proinflammatory The CD226/CD155 Interaction Regulates the (2013) (0)
Cannabinoids May Have a Neuroprotective Effect in MS (2004) (0)
Sa.92. Ligand Independent CTLA-4 Can Replace Some but Not All the Functions of Full Length CTLA-4 (2008) (0)
EncephalomyelitisSusceptibility to Experimental Autoimmune Cells Contribute to Gender Differences in Regulatory T + CD25+ Cutting Edge: CD4 (2005) (0)
Movie S5. Time-Lapse Imaging Shows the Migration of WT DCs along WT FRCs Cultured in 3D Matrix (2012) (0)
OR.26. Tim-3:Galectin-9 Pathway Expands Myeloid Suppressor Cells (2008) (0)
TIM-1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells through Apoptotic Cell Binding or TIM-1 Ligation.: Abstract# 2141 (2014) (0)
The PD-Ligand Pathway regulates the development, maintenance and function of induced regulatory T cells in vitro and in vivo (49.16) (2010) (0)
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis (2018) (0)
Induction and transcriptional regulation of the co-inhibitory gene module in T cells (2018) (0)
Transcription Factor T-bet CTL Activity via the + IL-21 Promotes CD8 (0)
Crystal structure of E99A mutant of human CEACAM1 (2021) (0)
A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes (2023) (0)
The Antigen T cell Receptor: Selected Protocols and Applications (1997) (0)
Transcriptomic and Epigenomic Regulation of Leukocytes by the Polyamine Pathway (2020) (0)
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation Please share how this access benefits you. Your story matters (2015) (0)
Identification of a transcriptional regulator of pathogenicity of Th17 cells (2014) (0)
Single-cell clonotype tracing of tissue Th17 cells during CNS autoimmunity reveals the conversion of intestinal homeostatic cells to pathogenic cells (2021) (0)
P120 IL-23 receptor signaling is important during physiological bone remodeling and radial bone growth through regulation of osteoblast differentiation (2019) (0)
Faculty Opinions recommendation of Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. (2012) (0)
Encephalomyelitis by Its Action on APCs Effector Phase of Experimental Autoimmune Abrogates Disease during the Tissue-Damage Blockade a 2 Cytosolic Phospholipase A (2011) (0)
Immune Checkpoint Molecule TIGIT Regulates Kidney T Cell Functions and Contributes to AKI (2023) (0)
Mice from Autoimmunity -Transgenic Th3 Cells Rescue IL-2-Deficient b Th3 Cells in Peripheral Tolerance. II. TGF-WeinerYijun (2006) (0)
Anti-TIM-4 mediates long-term engraftment of islet allografts by promoting IL-10 expression by TIM-1+ Bregs and inhibiting IFNγ expression by proinflammatory “Be1” B cells (IRC3P.464) (2014) (0)
Congress Schedule (1998) (0)
Inhibitory Functions Cutting Edge: TIGIT Has T Cell-Intrinsic (2010) (0)
Correction (2005) (0)
Abstract 3657: Upregulation of PD-1 and Tim-3 expression on tumor antigen-specific CD4+ T cells is associated with reversible T cell dysfunction in patients with advanced melanoma (2011) (0)
Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and Survival (2007) (0)
Faculty Opinions recommendation of Mina, an Il4 repressor, controls T helper type 2 bias. (2009) (0)
CTL differentiation and function (WS-108) Chairpersons: Hideo Yagita, Laurence Boumsell (2010) (0)
Cell adhesion in immunity (WS-103) Chairpersons: Tatsuo Kinashi, Sirpa Jalkanen (2010) (0)
“LESS IS MORE”: APC WITH WEAKER CO-STIMULATORY ACTIVITIES SUPPORT BETTER CONVERSION OF NAÏVE T CELLS (2006) (0)
Cytokines and T Cell Subsets (2010) (0)
Defect in TIM-3 Regulation of CD4+ T Cells in a Human Autoimmune Disease (2007) (0)
OR.21. Idd5.4 On Chromosome 1 Mediates Resistance to Experimental Autoimmune Encephalomyelitis (2006) (0)

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