Vilhelm A. Bohr

Vilhelm A. Bohr's AcademicInfluence.com Rankings

Vilhelm A. Bohr

Biology

#4233

World Rank

#6345

Historical Rank

Molecular Biology

#314

World Rank

#319

Historical Rank

Biochemistry

#430

World Rank

#510

Historical Rank

biology Degrees

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Biology

Vilhelm A. Bohr's Degrees

PhD Biochemistry University of Copenhagen

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Vilhelm A. Bohr's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall (1985) (1158)
Ageing as a risk factor for neurodegenerative disease (2019) (1032)
Metformin improves healthspan and lifespan in mice (2013) (1031)
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin (2008) (999)
Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival (2007) (752)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease (2019) (740)
p53 modulation of TFIIH–associated nucleotide excision repair activity (1995) (590)
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases (2001) (577)
Base excision repair of oxidative DNA damage and association with cancer and aging. (2008) (575)
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction (2014) (499)
Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells* (1997) (497)
Preferential DNA repair of an active gene in human cells. (1986) (439)
Human RecQ helicases in DNA repair, recombination, and replication. (2014) (434)
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms (2017) (433)
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model (2019) (429)
CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice (2013) (411)
Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest (2000) (399)
Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases* (2002) (397)
Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. (2002) (369)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. (2016) (346)
The mechanics of base excision repair, and its relationship to aging and disease. (2007) (337)
DNA damage and repair in telomeres: relation to aging. (1995) (328)
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. (2001) (327)
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. (1992) (314)
A research agenda for aging in China in the 21st century (2015) (310)
Ku complex interacts with and stimulates the Werner protein. (2000) (305)
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. (2016) (303)
Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity* (2000) (298)
Functional and Physical Interaction between WRN Helicase and Human Replication Protein A* (1999) (297)
DNA repair deficiency in neurodegeneration (2011) (295)
Heterogeneous DNA damage and repair in the mammalian genome. (1987) (294)
SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair (2009) (285)
NAD+ in Aging: Molecular Mechanisms and Translational Implications. (2017) (276)
Nuclear DNA damage signalling to mitochondria in ageing (2016) (270)
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. (2014) (268)
SRT1720 improves survival and healthspan of obese mice (2011) (266)
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. (2006) (265)
NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency (2018) (264)
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity (2001) (262)
Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. (1992) (261)
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges. (2016) (259)
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment (2007) (255)
DNA Damage, DNA Repair, Aging, and Neurodegeneration. (2015) (252)
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2 (2005) (249)
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. (2008) (239)
Protecting the mitochondrial powerhouse. (2015) (235)
Role of DNA Polymerase β in the Excision Step of Long Patch Mammalian Base Excision Repair* (1999) (234)
Repair Pathways for Processing of 8-Oxoguanine in DNA by Mammalian Cell Extracts* (1998) (234)
No Association Between Telomere Length and Survival Among the Elderly and Oldest Old (2006) (232)
Mitochondrial DNA repair pathways. (1999) (231)
FEN1 Stimulation of DNA Polymerase β Mediates an Excision Step in Mammalian Long Patch Base Excision Repair* (2000) (221)
Deficient DNA repair capacity, a predisposing factor in breast cancer. (1996) (211)
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. (2018) (210)
Human Embryonic Stem Cells Have Enhanced Repair of Multiple Forms of DNA Damage (2008) (208)
Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines (1992) (203)
Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria (2008) (202)
Roles of Werner syndrome protein in protection of genome integrity. (2010) (201)
Mitochondrial DNA repair of oxidative damage in mammalian cells. (2002) (200)
Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein (1998) (195)
POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates* (2005) (191)
Human DNA polymerase β initiates DNA synthesis during long‐patch repair of reduced AP sites in DNA (2001) (191)
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. (2003) (190)
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. (2009) (186)
Human premature aging, DNA repair and RecQ helicases (2007) (183)
Repair of Formamidopyrimidines in DNA Involves Different Glycosylases (2005) (182)
DNA damage, mutation and fine structure DNA repair in aging. (1995) (181)
Mitophagy in neurodegeneration and aging (2017) (179)
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner (2006) (177)
DNA repair, mitochondria, and neurodegeneration (2007) (176)
Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene. (1986) (176)
Base excision repair in nuclear and mitochondrial DNA. (2001) (176)
Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos (1986) (174)
Gene specific DNA repair. (1991) (174)
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy (2012) (174)
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells. (1997) (168)
Age-associated change in mitochondrial DNA damage. (1998) (167)
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. (2001) (166)
Replication of an association of variation in the FOXO3A gene with human longevity using both case–control and longitudinal data (2010) (166)
Cockayne syndrome: Clinical features, model systems and pathways (2017) (165)
The HRDC domain of BLM is required for the dissolution of double Holliday junctions (2005) (162)
Mitochondrial DNA damage and repair in neurodegenerative disorders. (2008) (161)
Cockayne syndrome group B cellular and biochemical functions. (2003) (161)
Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation* (2002) (160)
Genomic heterogeneity of nucleotide excision repair. (2000) (152)
Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. (1991) (152)
The Cockayne Syndrome Group B Gene Product Is Involved in General Genome Base Excision Repair of 8-Hydroxyguanine in DNA* (2001) (152)
Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage (2003) (151)
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8‐hydroxyguanine and 8‐hydroxyadenine resulting from oxidative stress (2003) (150)
An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria* (1997) (148)
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells. (1991) (147)
Gene expression profiling in Werner syndrome closely resembles that of normal aging (2003) (147)
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis (2008) (146)
Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein. (1997) (143)
Oxidative DNA damage processing in nuclear and mitochondrial DNA. (1999) (143)
A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. (2000) (140)
Colocalization, Physical, and Functional Interaction between Werner and Bloom Syndrome Proteins* (2002) (140)
Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. (1999) (138)
The Werner syndrome protein is involved in RNA polymerase II transcription. (1999) (137)
Mitochondrial DNA repair and association with aging – An update (2010) (137)
Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis. (1997) (136)
The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53* 210 (2002) (130)
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane (2010) (130)
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging (2008) (130)
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β (2006) (129)
Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria. (1999) (128)
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (2019) (127)
Cooperation of the Cockayne Syndrome Group B Protein and Poly(ADP-Ribose) Polymerase 1 in the Response to Oxidative Stress (2005) (121)
The Werner Syndrome Protein Stimulates DNA Polymerase β Strand Displacement Synthesis via Its Helicase Activity* (2003) (120)
The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life (2003) (120)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52* (2003) (120)
Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1* (2004) (120)
Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein* (2011) (119)
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. (2013) (119)
Unwinding of a DNA Triple Helix by the Werner and Bloom Syndrome Helicases* (2001) (119)
Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains* (2003) (119)
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. (1998) (118)
BDNF and Exercise Enhance Neuronal DNA Repair by Stimulating CREB-Mediated Production of Apurinic/Apyrimidinic Endonuclease 1 (2014) (118)
Base excision repair capacity in mitochondria and nuclei: tissue‐specific variations (2002) (116)
Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction (2004) (116)
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates (2007) (115)
Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3. (1993) (115)
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. (1999) (115)
The mitochondrial transcription factor A functions in mitochondrial base excision repair. (2010) (114)
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B (2002) (113)
DNA repair fine structure and its relations to genomic instability. (1995) (109)
The role of DNA repair in brain related disease pathology. (2013) (108)
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. (2001) (107)
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway (2017) (107)
Aging processes, DNA damage, and repair 1 (1997) (107)
The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1* (2007) (106)
Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions (2011) (106)
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross‐sectional and longitudinal analysis (2012) (106)
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. (2011) (104)
Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome Protein* (2001) (103)
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein. (2002) (102)
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. (2002) (102)
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. (1991) (102)
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes (2014) (101)
RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance* (2011) (100)
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria (2004) (100)
Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein* (2004) (99)
p53 Modulates the Exonuclease Activity of Werner Syndrome Protein* (2001) (99)
Junction of RecQ Helicase Biochemistry and Human Disease* (2004) (97)
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein. (2004) (97)
Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase* (2009) (96)
RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity (2012) (96)
Mitochondrial endogenous oxidative damage has been overestimated (2000) (96)
Mitochondrial DNA, base excision repair and neurodegeneration. (2008) (94)
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links (2006) (92)
The Cockayne Syndrome Group B Gene Product Is Involved in Cellular Repair of 8-Hydroxyadenine in DNA* (2002) (92)
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. (2001) (92)
A UV-responsive G2 checkpoint in rodent cells (1995) (90)
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. (2005) (89)
The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo. (1999) (89)
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells (2013) (89)
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks (2016) (88)
NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING (2021) (88)
Pathways and functions of the Werner syndrome protein (2005) (88)
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity. (2004) (88)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest (2006) (88)
Neurons Efficiently Repair Glutamate-induced Oxidative DNA Damage by a Process Involving CREB-mediated Up-regulation of Apurinic Endonuclease 1* (2010) (86)
Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells. (1986) (86)
The involvement of human RECQL4 in DNA double‐strand break repair (2010) (84)
Regulation of WRN Helicase Activity in Human Base Excision Repair* (2004) (84)
Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias. (2002) (83)
Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts. (1999) (83)
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. (2008) (83)
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging (2009) (82)
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092 (2002) (82)
Third complementarity‐determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non‐mutated genes (2001) (82)
Aprataxin localizes to mitochondria and preserves mitochondrial function (2011) (82)
Mitochondria in the signaling pathways that control longevity and health span (2019) (81)
Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity (2013) (81)
Roles of the Werner syndrome protein in pathways required for maintenance of genome stability (2002) (81)
Single Nucleotide Patch Base Excision Repair Is the Major Pathway for Removal of Thymine Glycol from DNA in Human Cell Extracts* (2000) (81)
Direct and indirect roles of RECQL4 in modulating base excision repair capacity. (2009) (81)
The heritability of telomere length among the elderly and oldest-old. (2005) (80)
Preferential DNA repair of (6-4) photoproducts in the dihydrofolate reductase gene of Chinese hamster ovary cells. (1989) (79)
Mitochondrial DNA Repair Pathways (1999) (79)
Faculty Opinions recommendation of Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (2017) (79)
Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. (1998) (79)
Mitochondria-targeted Ogg1 and Aconitase-2 Prevent Oxidant-induced Mitochondrial DNA Damage in Alveolar Epithelial Cells* (2014) (78)
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells. (1997) (78)
Genome instability in Alzheimer disease (2017) (78)
Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution (2003) (77)
Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction (2005) (76)
Oxidized guanine lesions and hOgg1 activity in lung cancer (2005) (75)
Quantification of aminofluorene adduct formation and repair in defined DNA sequences in mammalian cells using the UVRABC nuclease. (1989) (74)
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. (2008) (74)
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage. (1999) (73)
Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide. (1992) (73)
Phosphorylation of human oxoguanine DNA glycosylase (α-OGG1) modulates its function (2005) (73)
Compromised Incision of Oxidized Pyrimidines in Liver Mitochondria of Mice Deficient in NTH1 and OGG1 Glycosylases* (2003) (73)
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies (2012) (72)
DNA Polymerase Beta Participates in Mitochondrial DNA Repair (2017) (72)
Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases (2016) (70)
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. (2002) (70)
Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis. (2009) (70)
Mitochondrial repair of 8-oxoguanine and changes with aging (2002) (69)
WRN regulates pathway choice between classical and alternative non-homologous end joining (2016) (69)
Gene-specific DNA repair in xeroderma pigmentosum complementation groups A, C, D, and F. Relation to cellular survival and clinical features. (1993) (69)
Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging (2020) (69)
DNA repair and its pathogenetic implications. (1989) (69)
RecQ helicases in DNA double strand break repair and telomere maintenance. (2012) (68)
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. (2010) (68)
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. (2016) (68)
Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrest (2004) (68)
A role for WRN in telomere-based DNA damage responses (2006) (68)
DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts. (2001) (67)
Mitochondrial deficiency in Cockayne syndrome (2013) (67)
Werner protein stimulates topoisomerase I DNA relaxation activity. (2003) (67)
Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans (2008) (67)
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. (2006) (67)
Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin. (1993) (67)
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice (2012) (67)
The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency (2011) (66)
Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice. (2009) (66)
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. (2000) (66)
Oxidative DNA damage processing and changes with aging. (1998) (66)
Studies on the role of topoisomerases in general, gene- and strand-specific DNA repair. (1993) (66)
RECQL4 in genomic instability and aging. (2012) (65)
Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage. (1994) (64)
DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts. (1993) (64)
Deficient DNA repair in the human progeroid disorder, Werner syndrome. (2005) (64)
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. (2000) (63)
Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions (2010) (62)
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells. (1990) (61)
Telomere reduction and telomerase inactivation during neuronal cell differentiation. (1996) (61)
Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells. (1996) (61)
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells (2003) (61)
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts (2000) (60)
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product (2002) (59)
Repair of persistent strand breaks in the mitochondrial genome (2012) (58)
Gene expression and DNA repair in progeroid syndromes and human aging (2005) (58)
Human RecQL4 helicase plays critical roles in prostate carcinogenesis. (2010) (58)
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair (2017) (57)
Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation (2012) (57)
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA (2016) (57)
Genome instability and DNA repair in brain, ageing and neurological disease (2007) (56)
DNA damage, DNA repair, ageing and age-related disease (2008) (56)
DNA repair in the metallothionein gene increases with transcriptional activation. (1987) (56)
Telomeric D-loops Containing 8-Oxo-2′-deoxyguanosine Are Preferred Substrates for Werner and Bloom Syndrome Helicases and Are Bound by POT1* (2009) (56)
Recent Advances in Understanding Werner Syndrome (2017) (55)
Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages. (1999) (55)
Mammalian 8-Oxoguanine DNA Glycosylase 1 Incises 8-Oxoadenine Opposite Cytosine in Nuclei and Mitochondria, while a Different Glycosylase Incises 8-Oxoadenine Opposite Guanine in Nuclei* (2003) (55)
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy (2019) (55)
Cellular dynamics and modulation of WRN protein is DNA damage specific (2005) (55)
SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates (2015) (54)
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. (2004) (54)
Gene-specific DNA repair of interstrand cross-links induced by chemotherapeutic agents can be preferential. (1993) (54)
Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells. (1999) (53)
Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts. (1999) (53)
Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice (2014) (53)
General method for quantifying base adducts in specific mammalian genes. (1988) (53)
The Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases (2015) (53)
Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease (2014) (52)
RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex. (2014) (51)
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability (2012) (51)
Base excision repair in the mammalian brain: Implication for age related neurodegeneration (2013) (51)
Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype. (2012) (51)
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. (2004) (50)
Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters Neurometabolic Functions in C57BL/6J Mice (2013) (50)
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging (2013) (50)
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein. (2003) (50)
The Werner Syndrome: A Model for the Study of Human Aging (2000) (49)
The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. (1999) (49)
DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. (2000) (49)
DNA damage and its processing. Relation to human disease (2002) (48)
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice. (2001) (48)
DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. (2001) (47)
The Recombination Protein RAD52 Cooperates with the Excision Repair Protein OGG1 for the Repair of Oxidative Lesions in Mammalian Cells (2009) (47)
Von Hippel-Lindau–Coupled and Transcription-Coupled Nucleotide Excision Repair–Dependent Degradation of RNA Polymerase II in Response to Trabectedin (2008) (47)
Efficient in vitro repair of 7-hydro-8-oxodeoxyguanosine by human cell extracts: involvement of multiple pathways. (1998) (46)
Cockayne syndrome group B protein has novel strand annealing and exchange activities (2006) (46)
Heterochromatin: an epigenetic point of view in aging (2020) (46)
Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis (2014) (46)
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. (2011) (46)
WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexes (2011) (45)
Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair (2008) (45)
Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. (2015) (45)
CSB interacts with SNM1A and promotes DNA interstrand crosslink processing (2014) (45)
RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression (2011) (45)
Modulation of DNA base excision repair during neuronal differentiation (2013) (45)
Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome (2005) (45)
Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells (1989) (45)
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. (2002) (44)
Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population (2010) (44)
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures (2012) (44)
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice (1991) (44)
Increased sensitivity to cisplatin by nm23-transfected tumor cell lines. (1996) (43)
TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons (2006) (43)
Human diseases deficient in RecQ helicases. (2003) (43)
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. (2011) (42)
Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions. (2013) (42)
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients (2015) (41)
Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle (1995) (41)
DNA repair at the level of the gene. (1988) (41)
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer (2016) (41)
Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells. (1999) (41)
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria. (1998) (41)
Toward understanding genomic instability, mitochondrial dysfunction and aging (2018) (40)
Impact papers on aging in 2009 (2010) (40)
The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61. (1996) (40)
The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair. (2002) (40)
Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines. (1993) (40)
Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase. (1994) (40)
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease (2020) (40)
RECQL4 helicase has oncogenic potential in sporadic breast cancers (2016) (40)
Gene-specific repair of gamma-ray-induced DNA strand breaks in colon cancer cells: no coupling to transcription and no removal from the mitochondrial genome. (2000) (40)
Human RECQL1 participates in telomere maintenance (2014) (39)
Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders (2014) (39)
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. (1999) (39)
Modulation of Werner Syndrome Protein Function by a Single Mutation in the Conserved RecQ Domain* (2005) (39)
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress (2013) (38)
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary (2022) (38)
Lamin A/C promotes DNA base excision repair. (2019) (38)
Role of the ATPase domain of the Cockayne syndrome group B protein in UV induced apoptosis (2000) (38)
The role of WRN in DNA repair is affected by post-translational modifications (2007) (37)
Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells (2013) (37)
Methyl methanesulfonate adduct formation and repair in the DHFR gene and in mitochondrial DNA in hamster cells. (1993) (37)
Werner syndrome protein: biochemical properties and functional interactions (2000) (37)
Sarcopenia, Aging and Prospective Interventional Strategies. (2017) (37)
NAD+ Metabolism in Aging and Cancer (2019) (37)
Caffeine inhibits gene-specific repair of UV-induced DNA damage in hamster cells and in human xeroderma pigmentosum group C cells. (1995) (37)
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease (2012) (37)
Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells* (2011) (36)
Enzymatic mechanism of the WRN helicase/nuclease. (2006) (36)
Human exonuclease 1 (EXO1) activity characterization and its function on flap structures (2015) (36)
Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. (2002) (36)
Purification and Characterization of a Mitochondrial Thymine Glycol Endonuclease from Rat Liver* (1999) (36)
Increased gene specific repair of cisplatin induced interstrand crosslinks in cisplatin resistant cell lines, and studies on carrier ligand specificity. (1996) (36)
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. (2014) (35)
Recruitment and retention dynamics of RECQL5 at DNA double strand break sites. (2012) (35)
DNA repair fine structure in Werner's syndrome cell lines. (1996) (35)
Mitophagy and DNA damage signaling in human aging (2020) (35)
WRN exonuclease activity is blocked by DNA termini harboring 3′ obstructive groups (2007) (35)
Association study of FOXO3ASNPs and aging phenotypes in Danish oldest-old individuals (2014) (35)
NAD+ in DNA repair and mitochondrial maintenance (2017) (34)
Repair of ribosomal RNA genes in hamster cells after UV irradiation, or treatment with cisplatin or alkylating agents. (1993) (34)
Heterogeneous repair of methylnitrosourea-induced alkali-labile sites in different DNA sequences. (1991) (34)
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity (2014) (34)
Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase (2007) (33)
Expression of excision repair genes in non-malignant bone marrow from cancer patients. (1993) (33)
Fine structural analysis of DNA repair in mammalian cells. (1998) (33)
NAD+ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy (2021) (33)
DNA repair and mutagenesis in Werner syndrome (2001) (33)
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (2012) (33)
Telomere length among the elderly and oldest-old. (2005) (32)
Human repair gene restores normal pattern of preferential DNA repair in repair defective CHO cells. (1988) (32)
Human RECQL5 participates in the removal of endogenous DNA damage (2012) (32)
3-Aminobenzamide stimulates unscheduled DNA synthesis and rejoining of strand breaks in human lymphocytes. (1981) (32)
Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: Molecules to patients (2011) (32)
Intrinsic ssDNA annealing activity in the C-terminal region of WRN. (2008) (32)
Loss of intragenomic DNA repair heterogeneity with cellular differentiation. (1991) (32)
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair. (1998) (32)
DNA Damage and Mitochondria in Cancer and Aging. (2020) (31)
A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro. (2001) (31)
DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease (2016) (31)
NAD+: The convergence of DNA repair and mitophagy (2017) (31)
Oxidative stress and mitochondrial DNA repair: implications for NRTIs induced DNA damage. (2004) (31)
DNA repair in genes. (1988) (31)
Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability (2013) (31)
Human premature aging syndromes and genomic instability (2002) (30)
Age-Related Disease Association of Endogenous γ-H2AX Foci in Mononuclear Cells Derived from Leukapheresis (2012) (30)
Mitochondrial base excision repair assays. (2010) (30)
Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients (2004) (30)
The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications (2019) (30)
DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA. (1999) (29)
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy (2020) (29)
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain (2016) (29)
Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance (2013) (29)
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers. (2016) (29)
Immunofluorescent analysis of the organization of telomeric DNA sequences and their involvement in chromosomal aberrations in hamster cells. (1996) (29)
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal. (2009) (29)
DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities (2012) (28)
The Identification of a SIRT6 Activator from Brown Algae Fucus distichus (2017) (28)
Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction (2020) (27)
DNA base excision repair activities in mouse models of Alzheimer's disease (2009) (27)
Impact of Age on Hypermutation of Immunoglobulin Variable Genes in Humans (2001) (27)
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand (2008) (27)
Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops (2010) (27)
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality (2007) (27)
Nucleolin Inhibits G4 Oligonucleotide Unwinding by Werner Helicase (2012) (27)
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation. (2008) (26)
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. (2017) (26)
DNA damage invokes mitophagy through a pathway involving Spata18. (2020) (26)
Mitochondria, oxidative DNA damage, and aging (2000) (26)
The role of DNA base excision repair in brain homeostasis and disease. (2015) (26)
Gene-specific DNA repair of UV-induced cyclobutane pyrimidine dimers in some cancer-prone and premature-aging human syndromes. (1994) (26)
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage (2012) (25)
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks (2014) (25)
Enhanced repair of pyrimidine dimers in coding and non-coding genomic sequences in CHO cells expressing a prokaryotic DNA repair gene. (1987) (25)
Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis (2014) (25)
Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance (2015) (25)
Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation. (2020) (25)
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. (2013) (24)
Redundancy of DNA helicases in p53-mediated apoptosis (2006) (24)
Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver (2011) (24)
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome (2020) (24)
Human RECQL5{beta} stimulates flap endonuclease 1 (2010) (23)
Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle. (2019) (23)
Enzymatic Activities and DNA Substrate Specificity of Mycobacterium tuberculosis DNA Helicase XPB (2012) (23)
NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB (2017) (23)
Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells (2015) (23)
Werner syndrome protein associates with γH2AX in a manner that depends upon Nbs1 (2005) (23)
Pathways defective in the human premature aging disease Werner syndrome (2004) (23)
Multiple RPAs make WRN syndrome protein a superhelicase (2018) (23)
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans. (2008) (23)
Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center. (2005) (23)
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction (2020) (22)
Olfactory dysfunction in aging and neurodegenerative diseases (2021) (22)
Human RECQL5β stimulates flap endonuclease 1 (2010) (22)
DNA repair in lymphocytes from patients with secondary leukemia as measured by strand rejoining and unscheduled DNA synthesis. (1985) (22)
Current and emerging roles of Cockayne syndrome group B (CSB) protein. (2021) (22)
Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging. (2019) (22)
The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage (2007) (21)
Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase (2007) (21)
Preferential and strand-specific DNA repair of (6-4) photoproducts detected by a photochemical method in the hamster DHFR gene. (1992) (21)
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation (2021) (20)
Telomerase activity is elevated in early S phase in hamster cells. (1997) (20)
RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity. (2012) (20)
Mitochondrial DNA repair. (2001) (20)
Transcription-coupled repair is inducible in hamster cells. (2000) (20)
The role of RecQ helicases in non-homologous end-joining (2014) (20)
The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus. (2011) (20)
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. (2005) (19)
Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein. (2000) (19)
Gene-specific repair of DNA damage induced by UV irradiation and cancer chemotherapeutics. (1991) (19)
Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. (2019) (18)
Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells. (1991) (18)
DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene. (1992) (18)
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling (2020) (18)
A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins (2004) (17)
Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice (2015) (17)
Mammalian DNA repair responses and genomic instability. (1996) (17)
Comparative effects of growth inhibitors on DNA replication, DNA repair, and protein synthesis in human epidermal keratinocytes. (1986) (17)
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN) (2019) (17)
A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: Decrease in mitochondrial DNA repair activity during ageing (2009) (16)
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase (2020) (16)
Loss of NEIL1 causes defects in olfactory function in mice (2015) (16)
Functional deficit associated with a missense Werner syndrome mutation. (2013) (16)
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. (2016) (16)
Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms (2010) (16)
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. (2010) (16)
RECQL 4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks Graphical (2017) (16)
PHOTOTOXIC EFFECTS OF FOUR PSORALENS ON L1210 CELLS. THE CORRELATION WITH DNA INTERSTRAND CROSS‐LINKING (1983) (16)
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases (2008) (16)
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. (2014) (16)
Neurogenesis in aging and age-related neurodegenerative diseases (2022) (15)
Mitochondrial DNA Repair and Cell Injury (1993) (15)
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology (2021) (15)
Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence. (1999) (15)
Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro. (2000) (15)
Enhanced mitochondrial DNA repair of the common disease‐associated variant, Ser326Cys, of hOGG1 through small molecule intervention (2018) (15)
The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events (2015) (15)
Special article: Antineoplastic drug resistance and DNA repair (1991) (15)
Emerging Antitumor Activities of the Bitter Melon (Momordica charantia). (2019) (15)
Gene-specific and mitochondrial repair of oxidative DNA damage. (2006) (15)
Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions* (2007) (15)
New areas of focus at workshop on human diseases involving DNA repair deficiency and premature aging (2007) (15)
Homogeneous rate of degradation of nuclear DNA during apoptosis. (1998) (14)
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis (2017) (14)
Aging—From molecules to populations (2008) (14)
DNA repair and transcription in human premature aging disorders. (1998) (14)
Rapid gene-specific repair of cisplatin lesions at the human DUG/DHFR locus comprising the divergent upstream gene and dihydrofolate reductase gene during early G1 phase of the cell cycle assayed by using the exonucleolytic activity of T4 DNA polymerase. (1994) (14)
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. (2019) (14)
Telomeric length in individuals and cell lines with altered p53 status. (1999) (14)
Factors that affect the initiation of excision-repair in chromatin. (1984) (13)
DNA repair defects associated with chromosomal translocation breaksite regions (1994) (13)
Genetic and environmental influence on DNA strand break repair: A twin study (2013) (13)
Base excision repair activities differ in human lung cancer cells and corresponding normal controls. (2010) (13)
Restoration of preferential and strand specific gene repair in group 2 Chinese hamster ovary mutants (UV5) by the XPD (ERCC2) gene. (1997) (13)
DNA repair, oxidative stress and aging (1995) (13)
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. (2006) (13)
Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities (2015) (13)
Identification of phage antibodies toward the Werner protein by selection on Western blots (2000) (13)
The Cockayne syndrome group B protein is a functional dimer (2005) (13)
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase (2016) (13)
The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients (2012) (13)
A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets (2021) (12)
Psoralen-DNA crosslink repair in human lymphocytes. Comparison of alkaline elution with electron microscopy. (1984) (12)
WRN's tenth anniversary. (2006) (12)
Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal (2014) (12)
Overexpression of metallothionein in Chinese hamster ovary cells and its effect on nitrogen mustard-induced cytotoxicity: role of gene-specific damage and repair. (1992) (12)
Self-assembly of multi-component mitochondrial nucleoids via phase separation (2019) (12)
Genomic Instability and DNA Repair (2005) (12)
A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function (2015) (11)
Impact papers on aging in 2009 - eScholarship (2010) (11)
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase (2012) (11)
The Heritability of Telomere Length Among the Elderly and Oldest-Old (2005) (11)
Preferential DNA repair in active genes. (1987) (11)
Novobiocin does not inhibit DNA repair in an active gene. (1986) (10)
Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand (2009) (10)
DNA repair in a UV resistant Chinese hamster ovary cell line. (1995) (10)
DNA repair and the accumulation of oxidatively damaged DNA are affected by fruit intake in mice. (2010) (10)
The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. (2013) (9)
Telomere, telomerase and aging (2008) (9)
Nutrition and aging (2010) (9)
Mitochondrial helicases and mitochondrial genome maintenance (2010) (9)
DNA damage responses in central nervous system and age-associated neurodegeneration (2017) (9)
DNA interstrand crosslinks visualized by electron microscopy in PUVA-treated psoriasis. (1979) (9)
Characterization of specialized mtDNA glycosylases. (2002) (9)
Gene-specific repair in human CD4+ lymphocytes reflects transcription and proliferation. (1996) (9)
Faculty of 1000 evaluation for Repair Pathway Choices and Consequences at the Double-Strand Break. (2017) (9)
Special Issue on the segmental progeria Cockayne syndrome (2013) (9)
Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions (2019) (9)
Antineoplastic drug resistance and DNA repair. (1991) (9)
Oxidative stress and DNA damage–DNA repair system in vascular smooth muscle cells in artery and vein grafts (2006) (8)
Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline (2015) (8)
The C-terminal Domain of p 21 Inhibits Nucleotide Excision Repair In Vitro and In Vivo (1999) (8)
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs (2021) (8)
Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase. (2016) (8)
Effects of purine riboside on nucleic acid synthesis in ascites cells. (1978) (8)
Skin Abnormalities in Disorders with DNA Repair Defects, Premature Aging, and Mitochondrial Dysfunction. (2020) (8)
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease. (2011) (7)
Werner syndrome resembles normal aging (2009) (7)
Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins (2018) (7)
Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli (2014) (7)
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome (2020) (7)
The role of DNA damage and repair in cell aging (2001) (7)
Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface. (2014) (7)
Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging (2021) (7)
A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation (2022) (7)
Transplantation and aging. (2006) (7)
Gene specific damage and repair after treatment of cells with UV and chemotherapeutical agents. (1991) (7)
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities. (2021) (7)
Gene-specific DNA repair and steady state transcription of the MDR1 gene in human tumor cell lines. (1996) (6)
Cockayne syndrome, underlying molecular defects and p53 (2011) (6)
141 Mitochondrial transcription factor a mitochondrial DNA repair (2010) (6)
In vitro crosslinking of DNA by 8-methoxypsoralen visualized by electron microscopy. (1978) (6)
The Anti-Aging Efficacy of Natural Compounds (2012) (6)
The effect of aphidicolin in DNA repair on resting and mitogen stimulated human lymphocytes. (1982) (6)
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins. (2018) (6)
Telomere Length Among the Elderly and Oldest-Old (2005) (6)
Gene specific DNA repair of damage induced in familial Alzheimer disease cells by ultraviolet irradiation or by nitrogen mustard. (1995) (6)
Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry (2012) (6)
Effect of aging on EGF‐stimulated replication of specific genes in rat hepatocytes (1998) (6)
Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy (2021) (6)
Peripheral blood leukocytes as a surrogate marker for cisplatin drug resistance: studies of adduct levels and the repair gene ERCC1. (1990) (6)
Pentoxifylline inhibits gene‐specific repair of UV‐induced DNA damage in hamster cells (1996) (6)
Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair. (2019) (6)
Aging, longevity and health (2011) (5)
Opinion section on frailty (2008) (5)
Quantitation of 2‐amino‐3‐methylimidazo[4,5‐f]quinoline and 2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease (1993) (5)
Editorial [zu: Mechanisms of Ageing and Development ; 151 (2015)] (2015) (5)
Heterogeneity of DNA repair: implications for human disease and oncology. (1990) (5)
DNA damage response , bioenergetics , and neurological disease : The challenge of maintaining brain health in an aging human population (2013) (5)
Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells. (1994) (5)
DNA-Related Pathways Defective in Human Premature Aging (2002) (5)
Mitochondria and aging (2010) (5)
DNA repair in the endogenous and episomal amplified c-myc oncogene loci in human tumor cells. (1995) (5)
DNA Repair mechanisms : proceedings of the Alfred Benzon Symposium 35 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, 9-13 August 1992 (1993) (4)
Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene. (2007) (4)
DNA damage response, bioenergetics, and neurological disease: The challenge of maintaining brain health in an aging human☆,☆☆,★ (2013) (4)
CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice (2021) (4)
Gene-specific damage and repair of DNA adducts and cross-links. (1994) (4)
LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage. (2021) (4)
DNA repair in drug resistance: studies on the repair process at the level of the gene. (1991) (4)
Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway (2022) (4)
Decoupling of DNA excision repair and RNA transcription in translocation breaksite regions of plasmacytoma-susceptible BALB/cAnPt mice. (1997) (4)
Acquired Localized Cutis Laxa due to Increased Elastin Turnover (2016) (4)
Werner syndrome and its protein: clinical, cellular and molecular advances (2003) (4)
Overview of DNA Repair Pathways (2013) (4)
Preface (2014) (4)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest (2006) (4)
Syddansk Universitet Association study of FOXO 3 A SNPs and aging phenotypes in Danish oldest-old individuals (2015) (4)
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians (2021) (4)
Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells. (1999) (4)
Special issue on cancer and ageing (2009) (3)
The DNA Repair Interest Group: a global village. (2005) (3)
Faculty of 1000 evaluation for WRN mutation update: mutation spectrum, patient registries, and translational prospects. (2017) (3)
DNA Repair in Mammalian Mitochondria (2002) (3)
NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways. (2021) (3)
Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis (2018) (3)
RECQL 5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression (2012) (3)
[Treatment of whooping cough in newborn infants with chloramphenicol and sulfadiazine/trimethoprim]. (1981) (2)
Topical treatment of psoriasis with the topoisomerase inhibitors novobiocin and nalidixic acid: A pilot study (2004) (2)
Diverse dealings of the Werner helicase/nuclease. (2003) (2)
Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice (2022) (2)
Genomic Instability in Human Premature Aging (2003) (2)
Toward a rational therapy for psoriasis. (1985) (2)
WERNER SYNDROME AND THE FUNCTION OF (2003) (2)
Measurement of Oxidatively Induced Base Lesions in Liver Nuclear and Mitochodrial DNA from Wistar Rats of Different Ages | NIST (1999) (2)
Advances in Brief Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase ( OGG 1 ) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG 1-defective Mice (2001) (2)
DNA repair and transcriptional activity in genes. (1988) (2)
DNA in psoriatic epidermis. (1979) (2)
DNA repair at the level of the gene: molecular and clinical considerations (2005) (1)
3"-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine do not inhibit gene-specific DNA repair in hamster cells. (1995) (1)
Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome (2001) (1)
Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance (2010) (1)
Corrigendum to "Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair" [DNA Repair 79 (2019) 22-31]. (2019) (1)
human ovarian cancer cell lines. interstrand cross-links in cisplatin-resistant Increased gene-specific repair of cisplatin (2013) (1)
Human RECQL1 participates in telomere maintenance (2016) (1)
DNA interstrand crosslinks in normal human skin visualized by electron microscopy. (1978) (1)
[Telomere terminals and telomerase. The biological aging clock?]. (1999) (1)
Faculty of 1000 evaluation for Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. (2017) (1)
Regulation of the human Suv3 helicase on DNA by inorganic cofactors. (2015) (1)
Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism (2004) (1)
Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model (2022) (1)
DNA repair: front and center and not going away! (2012) (1)
Lack of correlation between repair of DNA interstrand cross-links and differential sensitivity of G0 and proliferating CD4+ lymphocytes towards cisplatin. (1999) (1)
DNA Repair and Neurological Diseases (1999) (1)
Gene Specific Damage and Repair of Platinum Adducts and Crosslinks (1991) (1)
Base excision repair capacity in mitochondria and nuclei: tissue-speciﬁc variations (2002) (1)
DNA damage and its processing with aging: Human premature aging syndromes as model systems (2001) (1)
RECQL5 plays both co‐operative and complementary roles with WRN syndrome helicase. (2013) (1)
Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids (2022) (1)
12 DNA Repair and Aging (2008) (1)
Base Excision Repair in Aging (2017) (1)
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks (2022) (1)
Gene Repair: Depletion of PADPRP by Antisense RNA Expression (1993) (1)
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase. (2016) (1)
Faculty Opinions recommendation of DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination. (2017) (0)
Molecular biology of aging : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, June 14-18, 1998 (1999) (0)
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair (2017) (0)
WRNing for the right DNA repair pathway choice (2022) (0)
[The International Year of the Elderly 1999]. (1999) (0)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease (2019) (0)
First US-EU DNA repair meeting: endogenous stress, National Conference Center, VA, USA, 14-18 October 2003. (2004) (0)
Sensitivity to Nitrogen Mustard Apoptosis in Burkitt ' s Lymphoma Cell Lines Differing in Relationship between DNA Cross-Links , Cell Cycle , and Updated (2006) (0)
The recombination protein RAD52 cooperates with the base excision repair protein OGG1 in the repair of oxidative DNA damage (2006) (0)
3rd International Genome Dynamics in Neuroscience Conference: “DNA repair and neurological disease” (2011) (0)
Preface (2007) (0)
Gene-specific and mitochondrial repair of oxidative DNA damage. (1999) (0)
Preferential Repair of Cisplatin Adducts in the Human DHFR Gene During G1 Phase Assayed with T4 DNA Polymerase (1994) (0)
Human Premature Aging Diseases (2006) (0)
Indo-US workshop on base excision DNA repair, brain function and aging (2012) (0)
BDNF and Exercise Enhance Neuronal DNA Repair by Stimulating CREB-Mediated Production of Apurinic/Apyrimidinic Endonuclease 1 (2013) (0)
Werner syndrome: association of premature aging and cancer predisposition (2013) (0)
RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice (2023) (0)
Faculty Opinions recommendation of DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. (2014) (0)
An evolving bioinformatics tool reveals mitochondrial pathology in diseases and aging (2012) (0)
Mitochondria‐Targeted Ogg1 and Aco‐2 Prevent Oxidant‐Induced Mitochondrial DNA Damage (2013) (0)
Impact papers on aging in 2009 Citation (2022) (0)
RecQ-helicase processing of G-rich DNA (2022) (0)
DNA damage and repair in telomeres : Relation to aging ( human telomeres (2005) (0)
[Reflections after International Year of the Elderly 1999]. (2000) (0)
Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity (2012) (0)
DNA damage, neurodegeneration and mitochondrial dysfunction (2017) (0)
DNA Repair and Transcription in Premature Aging Syndromes (1999) (0)
[Focusing on the molecular biology of aging]. (1999) (0)
Editorial (2007) (0)
Methods to Measure the Repair of Genes (1996) (0)
Characterization of RecQL4 biochemical and cellular functions (2011) (0)
P VI.4 Studies on the possible detection of drug-induced topoiso-merase I-DNA complexes by nucleotide excision repair (1997) (0)
Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli (2014) (0)
Stem Cells: A Cellular Fountain of Youth: Mark P. Mattson, Gary Van Zant (Eds.), Elsevier Press, Amsterdam, 2002, ISBN: 0-444-50731-0 (2003) (0)
Xeroderma pigmentosum group A protein modulates mitophagy through regulation of mitochondrial‐associated proteins (2013) (0)
[DNA repair--a fundamental factor in ageing and development of cancer]. (2006) (0)
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs (2021) (0)
Spatial Transcriptomics characterization of Alzheimer’s disease in the adult mouse brain (2019) (0)
Acknowledgement to referees 2002 (2003) (0)
Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis (2018) (0)
Werner syndrome protein works as a dimer for unwinding and replication fork regression (2022) (0)
Acknowledgement to referees 2003 (2004) (0)
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice (2023) (0)
Effects of lifespan-extending interventions on cognitive healthspan (2022) (0)
Methods to assess DNA damage and repair interspecies comparisons: Edited by R.G. Tardiff, P.H.M. Lohman and G.N. Wogan, Wiley and Sons; Chichester, 1994; xxiv + 257 pages. $45.00. ISBN 0-471-94256-1 (1994) (0)
Editorial (2015) (0)
276 A Small Molecule Inhibitor of the BLM Helicase That Modulates Chromosome Stability in Human Cells (2012) (0)
DNA repair in the c-myc locus. (1990) (0)
[Is the concept "otogenic meningitis" a misunderstanding?]. (2009) (0)
Faculty Opinions recommendation of Predictive impact of genetic polymorphisms in DNA repair genes on susceptibility and therapeutic outcomes to colorectal cancer patients. (2017) (0)
Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis (vol 7, 2017) (2018) (0)
S1/L3 - DNA repair in human diseases and aging (1998) (0)
Molekylær biologisk aldringsforskning (2007) (0)
Faculty Opinions recommendation of Werner syndrome: a model for sarcopenia due to accelerated aging. (2017) (0)
Chapter 21. DNA Damage Leads to Neurodegeneration via Mitochondrial Dysfunction (2020) (0)
Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA. (2023) (0)
[Telomeres--the beginning and the end]. (2010) (0)
Faculty of 1000 evaluation for Epigenetic regulation of ageing: linking environmental inputs to genomic stability. (2017) (0)
Faculty Opinions recommendation of The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription. (2017) (0)
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis (2017) (0)
Perspectivesin CancerResearch Heterogeneous DNA Damage and Repair in the Mammalian Genome1 (2006) (0)
1 Negative Regulation of STAT 3-mediated Cellular Respiration by SirT 1 (2011) (0)
[DNA repair, cancer and clinical picture]. (1988) (0)
Faculty Opinions recommendation of Absence of premature senescence in Werner's syndrome keratinocytes. (2017) (0)
P25 22 WP – LOSS OF HETEROGENEITY IN INTRAGENOMIC REPAIR DURING CELLULAR DIFFERENTIATION (1991) (0)
Linking Human RecQ Helicases to DNA Damage Response and Aging (2009) (0)
Altered spectra of hypermutation in antibodies from mismatch repair-deficient mice (1998) (0)
Erling Christen Seeberg (1946–2004) (2005) (0)
Faculty Opinions recommendation of Werner syndrome through the lens of tissue and tumour genomics. (2017) (0)
DNA and aging (2007) (0)
18. Interaction of poly(ADP-ribose) with the Werner protein and its involvement in the aging process (2009) (0)
DNA repair activity in Podospora anserina (2007) (0)
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model (2019) (0)
Nucleic Acids (DNA) Damage and Repair (2006) (0)
Gene-Speciﬁc and Strand-Speciﬁc DNA Repair in the G 1 and G 2 Phases of the Cell Cycle (1995) (0)
Werner Syndrome Protein Forms a Bidirectional Fork Regression Motor Whose Direction is Switched at DNA Modifications (2013) (0)
O VI.3 Regulation of gene repair and transcription in normal human cells, and in premature aging syndromes (1997) (0)
Cancer esearch cular and Cellular Pathobiology an RecQL 4 Helicase Plays Critical Roles in R state Carcinogenesis (2010) (0)
Human Premature Aging Disorders and Dysfunction of DNA Repair (2006) (0)
Age-associated DNA Damage Change in Mitochondrial (1998) (0)
Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins (2018) (0)
Mitophagy induction inhibits Tau phosphorylation in human cells and improves memory in a Tau C . elegans model of Alzheimer ' s disease (2018) (0)
Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo. (2023) (0)
142 Unraveling the potential role of human Suv3 in genome maintenance (2010) (0)
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy (2020) (0)
PNAS Plus Significance Statements (2013) (0)
Worldwide Studies on Cockayne Syndrome are Needed (2021) (0)
Increased Impact Factor for Mechanisms of Ageing and Development (2011) (0)
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians (2021) (0)
Functional of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. (2010) (0)
Faculty of 1000 evaluation for Non-homologous DNA end joining and alternative pathways to double-strand break repair. (2017) (0)

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Aarhus University
University of Ulsan
La Trobe University
Stanford University
American University
University of Copenhagen
Thomas Jefferson University

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