Virginia Zakian | Academic Influence

Virginia Zakian's AcademicInfluence.com Rankings

Virginia Zakian

Biology

#2583

World Rank

#4078

Historical Rank

#1146

USA Rank

Molecular Biology

#336

World Rank

#342

Historical Rank

#125

USA Rank

Genetics

#694

World Rank

#781

Historical Rank

#236

USA Rank

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Biology

Virginia Zakian's Degrees

Bachelors Biology University of California, Berkeley
Masters Genetics Stanford University

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Why Is Virginia Zakian Influential?

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According to Wikipedia, Virginia Zakian is the Harry C. Wiess Professor in the Life Sciences in the Department of Molecular Biology at Princeton University. She is the director of the Zakian Lab, which has done important research in topics such as telomere-binding protein, telomere recombination, and telomere position effects, at Princeton University. She is a fellow at the American Academy of Microbiology and the American Association for the Advancement of Science., and is an elected member of the National Academy of Sciences . Zakian served as the chair of "Princeton's Task force on the Status of Women Faculty in the Natural Sciences and Engineering at Princeton" from 2001-2003, in 2003 Zakian became Princeton University's representative to Nine Universities, Gender Equity Analysis She was elected as a member of the American Academy of Arts and Sciences in 2019.

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Virginia Zakian's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Structure and function of telomeres. (1989) (2132)
Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription (1990) (1365)
DNA secondary structures: stability and function of G-quadruplex structures (2012) (1100)
Telomeres: Beginning to Understand the End (1995) (842)
Loss of a yeast telomere: Arrest, recovery, and chromosome loss (1993) (809)
DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase (2011) (488)
Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae (1999) (460)
RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability (1990) (416)
The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. (2003) (407)
Saccharomyces telomeres acquire single-strand TG1–3 tails late in S phase (1993) (403)
Expansion and length-dependent fragility of CTG repeats in yeast. (1998) (399)
Pif1 family helicases suppress genome instability at G-quadruplex motifs (2013) (398)
Est1p As a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase (2002) (375)
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation (1994) (365)
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. (2000) (364)
The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo (2009) (331)
Evidence for a New Step in Telomere Maintenance (1996) (330)
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. (1996) (317)
Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. (2009) (297)
Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. (2002) (294)
ATM-related genes: What do they tell us about functions of the human gene? (1995) (290)
Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA (1986) (288)
Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End (2012) (286)
The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA (2000) (280)
Saccharomyces telomeres assume a non-nucleosomal chromatin structure. (1992) (269)
Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. (2000) (264)
G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae (2010) (236)
The yeast Pif1p helicase removes telomerase from telomeric DNA (2005) (230)
Cell cycle-dependent regulation of yeast telomerase by Ku (2004) (229)
Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome (1997) (226)
Pif1p helicase, a catalytic inhibitor of telomerase in yeast. (2000) (226)
Structure, function, and replication of Saccharomyces cerevisiae telomeres. (1996) (201)
Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. (2007) (197)
Unwinding the functions of the Pif1 family helicases. (2010) (197)
The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres (2001) (194)
Replication of each copy of the yeast 2 micron DNA plasmid occurs during the S phase (1979) (185)
The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. (2006) (175)
Ku: a multifunctional protein involved in telomere maintenance. (2005) (163)
Transcriptional silencing at Saccharomyces telomeres: implications for other organisms (2002) (161)
The yeast Pif1p DNA helicase preferentially unwinds RNA–DNA substrates (2007) (158)
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. (2010) (155)
Recombination occurs during telomere formation in yeast (1989) (154)
Sir Proteins, Rif Proteins, and Cdc13p BindSaccharomyces Telomeres In Vivo (1998) (141)
Construction, replication, and chromatin structure of TRP1 RI circle, a multiple-copy synthetic plasmid derived from Saccharomyces cerevisiae chromosomal DNA (1982) (140)
Telomere telomere recombination provides an express pathway for telomere acquisition (1990) (140)
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells (1996) (137)
Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA (2014) (134)
Saccharomyces cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities (2004) (134)
Getting to the end: telomerase access in yeast and humans (2003) (129)
The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. (1997) (128)
Telomere Folding Is Required for the Stable Maintenance of Telomere Position Effects in Yeast (2000) (122)
Roles of Pif1-like helicases in the maintenance of genomic stability (2006) (122)
Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA (2008) (120)
S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. (2006) (117)
Mitotic and meiotic stability of linear plasmids in yeast. (1983) (117)
An in vitro assay for saccharomyces telomerase requires EST1 (1995) (115)
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. (2007) (111)
Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid (1993) (110)
Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility (2003) (109)
Sequencing of Saccharomyces telomeres cloned using T4 DNA polymerase reveals two domains (1990) (103)
Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation (1989) (102)
TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae (1996) (100)
Two Pathways Recruit Telomerase to Saccharomyces cerevisiae Telomeres (2008) (99)
Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA. (1984) (99)
DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. (2012) (98)
CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae. (2000) (89)
Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. (1994) (89)
PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes (2017) (87)
Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. (1994) (87)
Life and Cancer Without Telomerase (1997) (84)
A flexible protein linker improves the function of epitope‐tagged proteins in Saccharomyces cerevisiae (2007) (82)
The Pif1p subfamily of helicases: region-specific DNA helicases? (2001) (81)
Gender Differences and Performance in Science (2005) (81)
Telomeres: Structures in need of unwinding (2010) (80)
Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions. (2001) (79)
Repair of chromosome ends after telomere loss in Saccharomyces. (2001) (76)
Reduced Rif2 and no Mec1 targets short telomeres for elongation rather than double-strand break repair (2010) (75)
The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro (2011) (74)
Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p. (2004) (73)
Origin of replication from Xenopus laevis mitochondrial DNA promotes high-frequency transformation of yeast. (1981) (72)
Murine Pif1 Interacts with Telomerase and Is Dispensable for Telomere Function In Vivo (2006) (72)
Telomeres: the beginnings and ends of eukaryotic chromosomes. (2012) (71)
The Schizosaccharomyces pombe Pfh1p DNA Helicase Is Essential for the Maintenance of Nuclear and Mitochondrial DNA (2008) (68)
Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. (2002) (66)
The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage (2014) (64)
Distribution of telomere-associated sequences on natural chromosomes in Saccharomyces cerevisiae (1988) (64)
Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae. (1995) (63)
Human PIF Helicase is Cell Cycle Regulated and Associates with Telomerase (2006) (62)
DNA repair at telomeres: keeping the ends intact. (2013) (62)
A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1 (2012) (60)
Rap1p telomere association is not required for mitotic stability of a C3TA2 telomere in yeast (2003) (57)
The Saccharomyces cerevisiae Telomerase Subunit Est3 Binds Telomeres in a Cell Cycle– and Est1–Dependent Manner and Interacts Directly with Est1 In Vitro (2011) (57)
Telomeric position effect in yeast. (1992) (57)
Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro. (1994) (55)
Sensitivity of Yeast Strains with Long G-Tails to Levels of Telomere-Bound Telomerase (2007) (54)
The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? (2011) (52)
ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. (2008) (51)
Electron microscopic analysis of DNA replication in main band and satellite DNAs of Drosophila virilis. (1976) (50)
Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres. (1995) (49)
Telomerase: what are the Est proteins doing? (2003) (48)
Replication and segregation of an unstable plasmid in yeast. (1982) (46)
How does the end begin? Formation and maintenance of telomeres in ciliates and yeast. (1990) (45)
Lack of positional requirements for autonomously replicating sequence elements on artificial yeast chromosomes. (1989) (43)
Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. (2012) (41)
Getting it done at the ends: Pif1 family DNA helicases and telomeres. (2016) (40)
The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres (2015) (39)
Effects of excess centromeres and excess telomeres on chromosome loss rates (1991) (39)
Isolation and characterization of sequences from mouse chromosomal DNA with ARS function in yeasts (1983) (37)
Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA. (1998) (37)
Replication and meiotic transmission of yeast ribosomal RNA genes. (1980) (35)
Genome Structure and Replication (1981) (32)
Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length (2015) (32)
Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity (2016) (32)
Subtelomeric Elements Influence But Do Not Determine Silencing Levels at Saccharomyces cerevisiae Telomeres (2007) (32)
5 Saccharomyces Telomeres: Function, Structure, and Replication (1995) (32)
Unwinding the functions of the Pif 1 family helicases (2010) (31)
The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening. (2014) (30)
Differential Nuclear Localization Does Not Determine the Silencing Status of Saccharomyces cerevisiae Telomeres (2007) (28)
Telomere Position Effect : Silencing Near the End (2007) (28)
Telomere functions: lessons from yeast. (1996) (26)
yces Tehwes Acquire Single-St- TG1-3 Tails Late in S Phase (1993) (24)
10 Telomere Position Effect: Silencing Near the End (2006) (23)
To fire or not to fire: origin activation in Saccharomyces cerevisiae ribosomal DNA. (2002) (23)
The Amino Terminus of the Saccharomyces cerevisiae DNA Helicase Rrm3p Modulates Protein Function Altering Replication and Checkpoint Activity (2004) (21)
Size threshold for Saccharomyces cerevisiae chromosomes: generation of telocentric chromosomes from an unstable minichromosome (1986) (19)
Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae (2018) (18)
Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP (2020) (18)
Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. (2013) (18)
Pif1 family DNA helicases: A helpmate to RNase H? (2019) (17)
Telomerase RNA is more than a DNA template (2016) (15)
Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding (2015) (15)
Structural and temporal analysis of telomere replication in yeast. (1993) (15)
The Ends Have Arrived (2009) (14)
Use of non-denaturing Southern hybridization and two dimensional agarose gels to detect putative intermediates in telomere replication inSaccharomyces cerevisiae (1992) (13)
Telomere formation in yeast (1989) (13)
Properties of the transcriptional enhancer in Saccharomyces cerevisiae telomeres. (1990) (13)
Cell biology: Telomeric tethers (2000) (12)
The SV40 A gene product suppresses the adenovirus H5ts125 defect in DNA replication. (1981) (12)
Supplemental Data Telomerase and Tel 1 p Preferentially Associate with Short Telomeres in S . cerevisiae (2007) (12)
One-hybrid systems for detecting protein-DNA interactions. (2001) (11)
Yeast L double-stranded ribonucleic acid is synthesized during the G1 phase but not the S phase of the cell cycle (1981) (11)
Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase (2015) (10)
Extrachromosomal elements cause a reduced division potential in nib 1 strains of Saccharomyces cerevisiae. (1989) (8)
Distribution of telomere-associated sequences in yeast. (1986) (8)
DNA sequence analysis of newly formed telomeres in yeast. (1989) (8)
The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity (2018) (8)
Nuclear structure: Taken with a grain of salt (1985) (8)
Characterization of the helicase activity and anti-telomerase properties of yeast Pif1p in vitro. (2010) (7)
Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. (2019) (7)
DNA replication through G-quadruplex motifs is promoted by the S . cerevisiae Pif 1 DNA helicase (2015) (7)
Saccharomyces cerevisiae linear chromosome stability (lcs) mutants increase the loss rate of artificial and natural linear chromosomes (1993) (5)
A new role for proteins subunits of RNase P: stabilization of the telomerase holoenzyme (2020) (5)
Not just Salk (2017) (5)
Genetic: Control of chromosome behaviour in yeast (1983) (5)
Distribution ofTelomere-Associated Sequences onNatural Chromosomes inSaccharomyces cerevisiae (1988) (4)
Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency (2013) (4)
Origin Activation andFormation ofSingle-Strand TG1.3Tails OccurSequentially inLateSPhaseon aYeast Linear Plasmid (1993) (4)
Identity crisis when telomeres left unprotected. (2010) (4)
Dna-Protein Interactions at Telomeres in Ciliated Protozoans (1988) (3)
Reduced Rif 2 and no Mec 1 targets short telomeres for elongation rather than double-strand break repair (2016) (3)
Formation and stability of linear plasmids in a recombination deficient strain of yeast (1985) (3)
Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding (2019) (3)
The acquisition and association of TG1–3 single-strand tails during replication of Saccharomyces telomeres (1993) (2)
Cell biology: Architecture of interphase nuclei (1984) (2)
Author response: Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA (2014) (2)
Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP (2020) (2)
21st Century Genetics: Mass Spectrometry of Yeast Telomerase. (2015) (2)
Faculty Opinions recommendation of Improving protein solubility: the use of the Escherichia coli dihydrofolate reductase gene as a fusion reporter. (2009) (1)
Telomere Length Regulation by the Pif1 DNA Helicase (1997) (1)
Plasmid associations with residual nuclear structures in Saccharomyces cerevisiae (1988) (1)
Women in biomedicine: encouragement. (1994) (1)
Ciliates: the molecular biology of ciliated protozoa. (1987) (1)
An inexpensive voltage stabilizer for photometric work (1962) (1)
Architecture of interphase nuclei. (1984) (1)
Telomere les(i/s)ons from a telomerase RNA mutant (2015) (1)
Lackofpositional requirements forautonomously replicating sequence elements onartificial yeast chromosomes (1989) (1)
The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage (2014) (1)
Faculty Opinions recommendation of Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. (2009) (1)
Faculty Opinions recommendation of Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. (2010) (0)
METHOD FOR MEASURING TRI-NUCLEOTIDE REPEAT EXPANSION (2011) (0)
28 Telomere DNA Replication, Telomerase, and Human Disease (2006) (0)
SizeThreshold forSaccharomyces cerevisiae Chromosomes: Generation ofTelocentric Chromosomes froman Unstable Minichromosome (1986) (0)
Faculty Opinions recommendation of De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. (2010) (0)
Pif1 helicases: helping replication forks maneuver past replication barriers (2013) (0)
New Members Appointed to NAGMS Council (2004) (0)
Faculty Opinions recommendation of ATP-induced helicase slippage reveals highly coordinated subunits. (2011) (0)
Telomere Replication in Saccharomyces cerevisiae (1992) (0)
telomere elongation. into Saccharomyces cerevisiae results in Introduction of extra telomeric DNA sequences (2013) (0)
Faculty Opinions recommendation of Cdc45: the missing RecJ ortholog in eukaryotes? (2011) (0)
Faculty Opinions recommendation of A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding. (2011) (0)
The fission yeast Pfh1 DNA helicase promotes fork progression through multiple types of replication obstacles (236.1) (2014) (0)
Letter to the editor. (1992) (0)
Women in Science (1992) (0)
Research Highlight Identity Crisis When Telomeres Left Unprotected (2009) (0)
Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. (2019) (0)
Pif1 family helicases promote mutation avoidance during DNA replication. (2022) (0)
Isolation andCharacterization ofSequences fromMouse Chromosomal DNA withARSFunction inYeasts (1983) (0)
Corrigendum: Isolation and characterization of two Saccharomyces cerevisiae genes that encode protein that bind to (TG 1-3 )(n) single strand telomeric DNA in vitro (Nucleic Acids Research, 1994, 22, 4906-4913)) (1994) (0)
Control of chromosome behaviour in yeast. (1983) (0)
Probing Helicase Dynamics on Nucleic Acids through Fluorescence-Force Measurements (2016) (0)

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