Vishva Dixit

Q: What Schools Are Affiliated With Vishva Dixit

Vishva Dixit is affiliated with the following schools: Ghent University, California Institute of Technology, University of Michigan, University of California, Los Angeles, University of California, Davis, University of Nairobi, Duke University

Vishva Dixit's AcademicInfluence.com Rankings

Vishva Dixit

Biology

#2334

World Rank

#3720

Historical Rank

Biotechnology

#15

World Rank

#15

Historical Rank

Molecular Biology

#185

World Rank

#189

Historical Rank

Genetics

#194

World Rank

#238

Historical Rank

biology Degrees

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Biology

Vishva Dixit's Degrees

Bachelors Biotechnology University of Nairobi
Masters Molecular Biology University of Nairobi

Why Is Vishva Dixit Influential?

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According to Wikipedia, Vishva Mitra Dixit is a physician of Indian origin who is the current Vice President of Discovery Research at Genentech. Early life and education Vishva Dixit was born in Kenya in 1956. His parents were both physicians, working for the British colonial authorities. Dixit was interested in science from an early age, and his parents encouraged him to pursue a career in medicine. He graduated in 1980 from the University of Nairobi with a Bachelor of Medicine and Bachelor of Surgery, becoming a medical doctor.

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Vishva Dixit's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Death receptors: signaling and modulation. (1998) (6143)
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex (1996) (3233)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
Cryopyrin activates the inflammasome in response to toxins and ATP (2006) (2901)
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis (1995) (2607)
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase (1995) (2244)
Caspases: Intracellular Signaling by Proteolysis (1997) (2143)
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling (2015) (2129)
Non-canonical inflammasome activation targets caspase-11 (2011) (1951)
Inflammasomes: mechanism of assembly, regulation and signalling (2016) (1886)
The Receptor for the Cytotoxic Ligand TRAIL (1997) (1845)
Mechanisms and Functions of Inflammasomes (2014) (1775)
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf (2004) (1754)
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling (2004) (1736)
An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (1997) (1650)
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway (1998) (1643)
Apoptosis control by death and decoy receptors. (1999) (1362)
Signaling in innate immunity and inflammation. (2012) (1269)
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (1997) (1253)
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 (2013) (1142)
An Induced Proximity Model for Caspase-8 Activation* (1998) (1128)
Apoptosis signaling. (2000) (1124)
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (2000) (1077)
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells* (1998) (1033)
Caspase activation: the induced-proximity model. (1999) (922)
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis (2007) (808)
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*) (1996) (804)
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014) (799)
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. (1995) (788)
Inflammasomes and their roles in health and disease. (2012) (774)
The ubiquitin ligase COP1 is a critical negative regulator of p53 (2004) (747)
Keratinocytes as initiators of inflammation (1991) (727)
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 (2011) (718)
Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95 (1996) (701)
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome (2009) (696)
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. (2007) (670)
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death (1997) (667)
Molecular Ordering of the Cell Death Pathway (1996) (632)
Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*) (1995) (630)
Mitochondrial reactive oxygen species drive proinflammatory cytokine production (2011) (601)
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival (2010) (592)
RAIDD is a new 'death' adaptor molecule (1997) (587)
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes (2016) (572)
Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies (2008) (564)
Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex* (1998) (561)
Target Protease Specificity of the Viral Serpin CrmA (1997) (559)
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis (2014) (534)
Death receptor signal transducers: nodes of coordination in immune signaling networks (2009) (528)
Caspase-9 Can Be Activated without Proteolytic Processing* (1999) (518)
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection (2006) (517)
Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4 (2004) (515)
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO (2004) (513)
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. (2002) (510)
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella (2010) (509)
The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A* (1996) (493)
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis (2010) (476)
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 (2012) (467)
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. (1992) (464)
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. (1991) (452)
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. (1992) (450)
A Deubiquitinase That Regulates Type I Interferon Production (2007) (448)
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis (1999) (446)
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis (2005) (438)
The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. (1992) (434)
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. (2003) (430)
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. (1990) (429)
Activation and accumulation of B cells in TACI-deficient mice (2001) (429)
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas (2000) (427)
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia (2010) (425)
Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. (2000) (418)
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency (2001) (414)
Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c * (1998) (410)
The domains of death: evolution of the apoptosis machinery. (1999) (408)
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death (2011) (402)
New Paradigm for Lymphocyte Granule-mediated Cytotoxicity (1996) (400)
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) (1999) (400)
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide (2008) (399)
Manipulation of host cell death pathways during microbial infections. (2010) (396)
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. (1995) (396)
Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase (2004) (381)
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI (2000) (381)
A novel RING finger protein interacts with the cytoplasmic domain of CD40. (1994) (378)
Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase (2003) (376)
FLICE Induced Apoptosis in a Cell-free System (1997) (376)
Inflammasomes: guardians of cytosolic sanctity (2009) (376)
The cell-death machine (1996) (374)
Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence (1985) (371)
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation (2012) (368)
TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling (1998) (366)
Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. (1990) (365)
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. (2010) (364)
Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation (2011) (352)
A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis* (1997) (350)
The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis (*) (1995) (349)
Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins (1997) (343)
RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase* (1998) (341)
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. (2001) (340)
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) (1996) (336)
Drugging the undruggables: exploring the ubiquitin system for drug development (2016) (324)
Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)* (1997) (323)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B* (1996) (323)
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. (1995) (305)
Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3* (2002) (296)
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. (2000) (288)
I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis* (1997) (287)
Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling* (1997) (282)
Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. (2001) (281)
Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor (1998) (280)
Signaling to NF-kappaB: regulation by ubiquitination. (2010) (275)
Phosphorylation of NLRC4 is critical for inflammasome activation (2012) (269)
A role for FADD in T cell activation and development. (1998) (267)
Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. (1990) (258)
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation (2005) (247)
ICEBERG A Novel Inhibitor of Interleukin-1β Generation (2000) (243)
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity (2000) (242)
Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation (1988) (236)
RIPK1 inhibits ZBP1-driven necroptosis during development (2016) (234)
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis (2019) (231)
Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis (*) (1995) (230)
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. (2004) (229)
Regulation of NF‐κB by deubiquitinases (2012) (224)
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest (2007) (221)
Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens (2011) (220)
CrmA, a Poxvirus-encoded Serpin, Inhibits Cytotoxic T-lymphocyte-mediated Apoptosis (*) (1995) (217)
Deubiquitinases in the regulation of NF-κB signaling (2011) (216)
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice (2001) (214)
Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo (1988) (210)
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases* (1996) (208)
Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1 (2009) (206)
Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. (1994) (204)
RIP3, a Novel Apoptosis-inducing Kinase* (1999) (203)
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation (2015) (203)
Role of CED-4 in the activation of CED-3 (1997) (199)
USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma (2011) (199)
NINJ1 mediates plasma membrane rupture during lytic cell death (2020) (194)
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control (2017) (190)
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. (1996) (187)
Boo, a novel negative regulator of cell death, interacts with Apaf‐1 (1999) (181)
14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules* (1996) (180)
Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. (1988) (179)
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling. (2010) (176)
Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins* (1996) (176)
Ceramide in apoptosis--does it really matter? (1998) (176)
SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)* (2002) (175)
CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) (1995) (175)
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. (1998) (172)
Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A (2005) (170)
The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. (1985) (169)
Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. (1991) (167)
A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein (1990) (164)
Ubiquitin in the activation and attenuation of innate antiviral immunity (2016) (160)
NF-κB Signaling Many Roads Lead To Madrid (2002) (158)
The PYRIN domain: A member of the death domain‐fold superfamily (2001) (157)
Activity of caspase-8 determines plasticity between cell death pathways (2019) (157)
COP1 is a tumour suppressor that causes degradation of ETS transcription factors (2011) (154)
Mice Lacking the CARD of CARMA1 Exhibit Defective B Lymphocyte Development and Impaired Proliferation of Their B and T Lymphocytes (2003) (154)
Caspase-14 Is a Novel Developmentally Regulated Protease* (1998) (153)
A monoclonal antibody against human thrombospondin inhibits platelet aggregation. (1985) (153)
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. (1984) (153)
Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. (1998) (153)
Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. (1994) (150)
Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. (2005) (150)
ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage (2006) (147)
The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10 (*) (1995) (147)
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. (1996) (144)
Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma (2016) (143)
COP1, the Negative Regulator of p53, Is Overexpressed in Breast and Ovarian Adenocarcinomas (2004) (139)
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (2011) (137)
Fiery Cell Death: Pyroptosis in the Central Nervous System (2019) (137)
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. (2009) (132)
Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. (1987) (129)
Regulation of death receptor signaling by the ubiquitin system (2010) (129)
MALT1/Paracaspase Is a Signaling Component Downstream of CARMA1 and Mediates T Cell Receptor-induced NF-κB Activation* (2004) (128)
Activation of caspases triggered by cytochrome c in vitro 1 (1998) (127)
Characterization of Calcium Release-activated Apoptosis of LNCaP Prostate Cancer Cells* (2000) (127)
Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase (*) (1995) (125)
Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (1992) (124)
mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule* (1999) (122)
Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals (2010) (122)
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A (2010) (121)
IL-33 raises alarm. (2009) (121)
Deposition and role of thrombospondin in the histogenesis of the cerebellar cortex (1990) (120)
Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. (1986) (119)
OTULIN limits cell death and inflammation by deubiquitinating LUBAC (2018) (119)
ICEBERG: a novel inhibitor of interleukin-1beta generation. (2000) (117)
NLRP3 recruitment by NLRC4 during Salmonella infection (2016) (117)
Activated T-cell adhesion to thrombospondin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins. (1993) (117)
Identification of a Novel Death Domain-Containing Adaptor Molecule for Ectodysplasin-A Receptor that Is Mutated in crinkled Mice (2002) (116)
ERICE, a Novel FLICE-activatable Caspase* (1998) (114)
Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling (2000) (113)
Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy (1987) (112)
Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-gamma. (1991) (111)
Apoptosis Induced by Drosophila Reaper and Grim in a Human System (1998) (109)
Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis. (1997) (107)
Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. (1986) (106)
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. (1995) (105)
Direct Association between the Ret Receptor Tyrosine Kinase and the Src Homology 2-containing Adapter Protein Grb7 (*) (1996) (105)
Identification of Paracaspases and Metacaspases (2000) (105)
Engineering and structural characterization of a linear polyubiquitin-specific antibody. (2012) (104)
Phosphorylation-dependent activity of the deubiquitinase DUBA (2012) (103)
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3 (1996) (103)
Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development. (1992) (102)
Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction. (1991) (102)
Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells. (1990) (102)
Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling (2013) (101)
Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing (1985) (101)
T‐cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection (1997) (101)
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A 1 in Vascular Endothelial Cells * (1998) (100)
A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome. (1991) (99)
Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation* (2004) (98)
Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina. (1997) (95)
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells (2014) (95)
All-trans retinoic acid stimulates growth of adult human keratinocytes cultured in growth factor-deficient medium, inhibits production of thrombospondin and fibronectin, and reduces adhesion. (1989) (95)
Recent advances in tumor necrosis factor and CD40 signaling. (1996) (93)
Ubiquitin-mediated regulation of TNFR1 signaling. (2008) (93)
IRF2 transcriptionally induces GSDMD expression for pyroptosis (2019) (92)
The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication (1997) (89)
All-trans retinoic acid stimulates growth and extracellular matrix production in growth-inhibited cultured human skin fibroblasts. (1990) (89)
The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2* (2006) (87)
NF-kappaB signaling. Many roads lead to madrid. (2002) (85)
Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis* (1997) (84)
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity. (2003) (83)
Cell Signalling: Receptor orphans find a family (1995) (82)
CD95 (APO-1/Fas)-associating signalling proteins. (1996) (82)
Thrombospondin-induced adhesion of human keratinocytes. (1988) (81)
Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma. (1991) (77)
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells (2017) (76)
Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. (1992) (76)
Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B. (1993) (73)
Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase (*) (1995) (70)
Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates. (1998) (69)
Role of the extracellular matrix protein thrombospondin in the early development of the mouse embryo (1990) (68)
Src-like adaptor protein (Slap) is a negative regulator of mitogenesis (1998) (67)
B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome. (1994) (67)
Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency (2004) (65)
Thrombospondin 3 is a developmentally regulated heparin binding protein. (1994) (64)
BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. (2003) (64)
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 (2019) (62)
Dying cells fan the flames of inflammation (2021) (60)
Stimulation of fibroblast proliferation by thrombospondin. (1989) (60)
Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins. (2007) (59)
Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers. (1992) (58)
Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin. (1986) (58)
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase‐1 activation in macrophages (2010) (57)
cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. (1994) (54)
Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells. (1997) (54)
Motility of human carcinoma cells in response to thrombospondin: relationship to metastatic potential and thrombospondin structural domains. (1993) (53)
Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6–deficient Mice (2001) (52)
Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism. (1991) (52)
Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X (2014) (52)
Elevated levels of syndecan-1 expression confer potent serum-dependent growth in human 293T cells. (1995) (52)
Properties of recombinant mouse thrombospondin 2 expressed in Spodoptera cells. (1994) (51)
The antimitogenic action of tumor necrosis factor is associated with increased AP-1/c-jun proto-oncogene transcription. (1989) (51)
Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin. (1985) (50)
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. (2020) (49)
Human keratinocytes synthesize and secrete the extracellular matrix protein, thrombospondin. (1987) (48)
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia (2020) (47)
Fyn-ADAP signaling via Carma1-Bcl10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2013) (47)
Thrombospondin binding by human squamous carcinoma and melanoma cells: relationship to biological activity. (1988) (46)
A20 edits ubiquitin and autoimmune paradigms (2011) (45)
Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. (1985) (45)
Signaling to NFk B : Regulation by Ubiquitination (2010) (44)
Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription. (1989) (42)
Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. (1984) (41)
The Inflammasomes (2009) (41)
National Academy of Sciences colloquium “ Proteolytic Processing and Physiological Regulation , ” held February 20 – 21 , 1999 , at the Arnold and Mabel Beckman Center in Irvine , CA . Caspase activation : The induced-proximity model (1999) (41)
Keratinocyte activation following T-lymphocyte binding. (1992) (40)
The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease* (1998) (40)
Isolation of the fibrinogen-binding region of platelet thrombospondin. (1984) (40)
Structure and chromosomal localization of the human thrombospondin gene. (1990) (40)
Modulation of K11-linkage formation by variable loop residues within UbcH5A. (2011) (40)
Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression. (1995) (39)
Integration of innate immune signalling by caspase-8 cleavage of N4BP1 (2020) (39)
High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth. (1993) (39)
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection. (2021) (39)
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1 (2015) (38)
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function (2019) (38)
Thrombospondin 3 Is a Pentameric Molecule Held Together by Interchain Disulfide Linkage Involving Two Cysteine Residues (*) (1995) (38)
Expression and initial characterization of a recombinant human thrombospondin heparin binding domain. (1989) (38)
Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation. (2019) (37)
In Retrospect: The inflammasome turns 15 (2017) (36)
cDNA Cloning and Characterization of a Cek7 Receptor Protein-tyrosine Kinase Ligand That Is Identical to the Ligand (ELF-1) for the Mek-4 and Sek Receptor Protein-tyrosine Kinases (*) (1995) (35)
Activation of human neutrophils increases thrombospondin receptor expression. (1991) (35)
Baculovirus-based Genetic Screen for Antiapoptotic Genes Identifies a Novel IAP* (1999) (35)
Production and utilization of extracellular matrix components by human melanocytes. (1989) (35)
Expression of thrombospondin in the adult nervous system (1994) (34)
Tumor type‐specific differences in cell‐substrate adhesion among human tumor cell lines (1987) (33)
Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma cells. (1992) (33)
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity (2016) (31)
Human carcinoma cells bind thrombospondin through a Mr 80,000/105,000 receptor. (1991) (31)
Synthesis of a thrombospondin-like cytoadhesion molecule by cells of the trabecular meshwork. (1991) (31)
Inhibitory effect of gamma interferon on cultured human keratinocyte thrombospondin production, distribution, and biologic activities. (1988) (30)
Modulation of Inflammasome Activity for the Treatment of Auto-inflammatory Disorders (2010) (30)
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification (2019) (30)
Corrigendum: Signaling by Fyn-ADAP via the Carma1–Bcl-10–MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2014) (29)
Monocyte killing of human squamous epithelial cells: role for thrombospondin. (1989) (29)
A20--a bipartite ubiquitin editing enzyme with immunoregulatory potential. (2014) (27)
Selective activation of PFKL suppresses the phagocytic oxidative burst (2021) (27)
Oligomeric assembly of thrombospondin in the endoplasmic reticulum of thyroid epithelial cells. (1996) (27)
Apoptosis: Searching for FLASH domains (1999) (26)
Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation. (2012) (26)
Role of ICE-proteases in apoptosis. (1996) (25)
Is SIRT2 required for necroptosis? (2014) (25)
Expression and analysis of COOH-terminal deletions of the human thrombospondin molecule (1989) (22)
Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells (1989) (22)
Increased Targeting of Donor Switch Region and IgE in Sγ1-Deficient B Cells (2010) (20)
Corrigendum to: Activation of caspases triggered by cytochrome c in vitro (FEBS 20097) (1998) (20)
Ubiquitin in Cell-Cycle Regulation and Dysregulation in Cancer (2017) (20)
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain (2018) (20)
Characterization of the platelet agglutinating activity of thrombospondin. (1985) (19)
Monocyte diapedesis through an in vitro vessel wall construct: inhibition with monoclonal antibodies to thrombospondin (1992) (19)
Masking MALT1: the paracaspase's potential for cancer therapy (2009) (18)
Rescue from a fiery death: A therapeutic endeavor (2019) (17)
Modulation of Squamous Carcinoma Cell Growth, Morphology, Adhesiveness and Extracellular Matrix Production by Interferon-γ and Tumor Necrosis Factor-α (1990) (17)
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination (2013) (17)
Modulation of fibronectin production in normal human melanocytes and malignant melanoma cells by interferon-gamma and tumor necrosis factor-alpha. (1989) (17)
Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. (2018) (16)
A new lead to NLRP3 inhibition (2017) (15)
Human carcinoma cells express receptors for distinct domains of thrombospondin. (1991) (14)
Unraveling TACIt functions (2005) (13)
Modulation of thrombospondin receptor expression during HL-60 cell differentiation. (1994) (12)
Unleashing cell death: the Fas–FADD complex (2010) (11)
Pillars article: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997. 278: 1612-1615. (2013) (11)
Response: Does Bid Play a Role in the DNA Damage Response? (2007) (9)
Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies. (2016) (8)
Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction (2007) (8)
Paradise revealed III: why so many ways to die? Apoptosis, necroptosis, pyroptosis, and beyond (2020) (8)
Purification of the death substrate poly(ADP-ribose) polymerase. (1997) (7)
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma (2018) (7)
Thrombospondin binding by keratinocytes: modulation under conditions which alter thrombospondin biosynthesis. (1990) (7)
Structure of human thrombospondin: complete amino acid sequence derived from cDNA. (1987) (7)
Cross Talk between Ubiquitination and Demethylation (2011) (7)
Immunology: In command of commensals (2011) (6)
Bacterial and Viral Pathogens Modulation of Inflammasome Pathways by (2012) (4)
Abstract LB-220: Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma (2015) (4)
GPS navigation of the protein-stability landscape (2009) (4)
Thrombospondin and tumor necrosis factor. (1992) (4)
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation (2016) (3)
RIPs: an emerging family of kinases involved in pro-inflammatory and apoptotic signaling. (1999) (3)
Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Subject Collection Signal Transduction The Hippo Pathway (2012) (3)
Ubiquitin Signaling to NF-κB (2016) (3)
Drug Discovery in Apoptosis (2009) (3)
A NovelImmediate-Early Response GeneofEndothelium Is Induced byCytokines andEncodes a Secreted Protein (1990) (2)
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 (2011) (2)
TBK1 and IKKε restrain cell death (2018) (2)
Jürg Tschopp (1951–2011) (2011) (2)
in Vivo and in Vitro Ligand with Tumor Necrosis Factor-related Apoptosis-inducing Agents in Human Gliomas Causes Synergistic Cytotoxicity Increased Death Receptor 5 Expression by Chemotherapeutic (2000) (2)
Modulation of squamous carcinoma cell growth, morphology, adhesiveness and extracellular matrix production by interferon-gamma and tumor necrosis factor-alpha. (1990) (2)
Advances in Brief COP 1 , the Negative Regulator of p 53 , Is Overexpressed in Breast and Ovarian Adenocarcinomas (2004) (1)
Faculty Opinions recommendation of NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. (2011) (1)
Signalling lessons from death receptors: the importance of cleavage (2010) (1)
Crystal structure of EDA-A1 (2003) (1)
Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome (2019) (1)
An interview with Vishva M. Dixit. (2013) (1)
Caspases: Intracellular Minireview Signaling by Proteolysis (1997) (1)
Methods of making recombinant proteins using inhibitors of apoptosis. (2000) (0)
Comprar Protein Discovery Technologies | Renata Pasqualini | 9780824754686 | Informa Healthcare (2007) (0)
Integration of innate immune signalling by caspase-8 cleavage of N4BP1 (2020) (0)
Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold (2003) (0)
OTULIN limits cell death and inflammation by deubiquitinating LUBAC (2018) (0)
1441 Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6–deﬁcient (2001) (0)
On the other hand , CD 28 has a major role in providing a (1998) (0)
Thrombospondin Structural Domains Thrombospondin : Relationship to Metastatic Potential and Motility of Human Carcinoma Cells in Response to Updated (2007) (0)
A process for the production of recombinant proteins by means of inhibitors of apoptosis (2000) (0)
Faculty Opinions recommendation of Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition. (2017) (0)
Violation of the sanctity of the cytosolic compartment provokes the wrath of the inflammasome (2009) (0)
The crystal structure of TNF family member EDA-A2 (2003) (0)
Abstract IA1: COP1: Tumor suppressor role revealed (2012) (0)
Signaling by ADAP via the Carma1-TAK1 axis is critical for pro-inflammatory cytokine production but not for cytotoxicity in NK cells. (IRM7P.477) (2014) (0)
Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide (2002) (0)
Paradise revealed III: why so many ways to die? Apoptosis, necroptosis, pyroptosis, and beyond (2020) (0)
"Death domain" -containing receptor 4 (DR4), a member of the TNF receptor super family, which binds to TRAIL (APO-2L) (1998) (0)
Replacement of Sϵ with Sμ reveals novel mechanistic insights into rearrangements of the IgH locus and cMyc chromosomal translocations (P1400) (2013) (0)
Modulation de la production de cytokines (2008) (0)
A process for the production of recombinant proteins with the use of apoptosis inhibitors (2000) (0)
Response to 'Secreted IgM versus BLyS in germinal center formation' (2000) (0)
APOPTOSIS DELIVERY AND SUBSEQUENT NECESSARY FOR CYTOSOLIC ENDOSOMOLYTIC AGENT IS GRANZYME B, BUT AN CELLS BIND AND INTERNALIZE Granule-mediated Cytotoxicity: TARGET New Paradigm for Lymphocyte Enzymology: (2014) (0)
COMMENTARY Cross Talk between Ubiquitination and Demethylation (2011) (0)
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis (2019) (0)
Erratum: Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells (Laboratory Investigation (1997) 77 (51-61)) (1998) (0)
Cardiology Clinics: Preface (2001) (0)
Abstract BS1-1: Transcription factor stability and stem cell maintenance (2017) (0)
Advances in Brief Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Human Gliomas Causes Synergistic Cytotoxicity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Vitro and in Vivo (2000) (0)
Stimulation of pibrablast proliferation by thrombospondin (1989) (0)
Faculty Opinions recommendation of Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. (2013) (0)
Faculty Opinions recommendation of Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. (2010) (0)
TBK1 and IKKε restrain cell death (2018) (0)
Faculty Opinions recommendation of FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. (2011) (0)
Signaling Lessons from Death Receptors (2010) (0)
CrmA inhibits TNFa-induced apoptosis by a mechanism upstream and distinct from Bcl-2 (1996) (0)
Faculty Opinions recommendation of Linear ubiquitination prevents inflammation and regulates immune signalling. (2011) (0)
Modulation of endothelial apoptosis by lipopolysaccharide involves A1 and A20 (1997) (0)
Faculty of 1000 evaluation for LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. (2018) (0)
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function (2019) (0)
The road to death: Caspases, cleavage, and pores (2023) (0)
Activity of caspase-8 determines plasticity between cell death pathways (2019) (0)
A process for the production of recombinant proteins using the apoptosis inhibitors (2000) (0)
Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome (2019) (0)
USP1 inhibition: a differentiation strategy for Osteogenic Sarcoma (2012) (0)
Modulation of keratinocyte behavior and extracellular matrix production by growth regulating factors (1988) (0)
Method for manufacturing recombinant proteins using inhibitors of apoptosis. (2000) (0)
Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin (2012) (0)
T-cell receptor ligation by peptide / MHC induces activation of a caspase in immature thymocytes : the molecular basis of negative selection generally involves thymocytes at the DP stage of (2013) (0)
Identification of Components of the Cell Death Pathway (1997) (0)
Domains of Thrombospondin Human Carcinoma Cells Express Receptors for Distinct (2013) (0)
CARCINOMA CELL THROMBOSPOND 1 N RECEPTORS MATERIALS AND METHODS Reagents and Materials (2006) (0)
E11 Multiple inflammasomes direct innate immune responses against Salmonella (2010) (0)
SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION (2000) (0)
COP1 and DET: Conserved regulatory molecules in photomorphogenesis and cancer (2005) (0)
Modulation of Fibronectin Production in Normal Human Melanocytes and Malignant Melanoma Cells by Interferon-Y and Tumor Necrosis Factor-a (2007) (0)
Solution Structure of the Extracellular Domain of BLyS Receptor 3 (BR3) (2003) (0)
Faculty Opinions recommendation of Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. (2011) (0)
Mapping Functional Domains of Human Platelet Thrombospondin with Electro-Blotting and High Sensitivity Sequencing (1987) (0)
Searching for FLASH domains. Authors' reply (1999) (0)

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