Viviana Gradinaru
#77,419
Most Influential Person Now
American neuroscientist and biomedical engineer
Viviana Gradinaru's AcademicInfluence.com Rankings
Viviana Gradinaruengineering Degrees
Engineering
#5367
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#6621
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Biomedical Engineering
#815
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#827
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Viviana Gradinarubiology Degrees
Biology
#6721
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#9497
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Neuroscience
#1150
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#1192
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Engineering Biology
Viviana Gradinaru's Degrees
- PhD Neurobiology Stanford University
- Bachelors Biomedical Engineering Johns Hopkins University
Why Is Viviana Gradinaru Influential?
(Suggest an Edit or Addition)According to Wikipedia, Viviana Grădinaru is a Romanian-American neuroscientist who is a Professor of Neuroscience and Biological Engineering at the California Institute of Technology. She develops neurotechnologies including optogenetics CLARITY tissue clearing, and gene delivery vectors. She has been awarded the Presidential Early Career Award for Scientists and Engineers and the National Institutes of Health Director's Pioneer Award. In 2019 she was a finalist for the Blavatnik Awards for Young Scientists. In 2020 she was awarded a Vilcek Prize for Creative Promise in Biomedical Science by the Vilcek Foundation.
Viviana Gradinaru's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease (2016) (2050)
- Structural and molecular interrogation of intact biological systems (2013) (1668)
- Optical Deconstruction of Parkinsonian Neural Circuitry (2009) (1436)
- Amygdala circuitry mediating reversible and bidirectional control of anxiety (2011) (1058)
- Molecular and Cellular Approaches for Diversifying and Extending Optogenetics (2010) (906)
- Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing (2014) (778)
- Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems (2017) (709)
- Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures (2010) (685)
- Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins (2011) (657)
- Global and local fMRI signals driven by neurons defined optogenetically by type and wiring (2010) (649)
- Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain (2015) (635)
- Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors (2018) (589)
- Targeting and Readout Strategies for Fast Optical Neural Control In Vitro and In Vivo (2007) (474)
- eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications (2008) (468)
- Dynamics of Retrieval Strategies for Remote Memories (2011) (465)
- Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning (2010) (439)
- Negative feedback control of neuronal activity by microglia (2020) (360)
- Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex (2017) (273)
- Bioelectronic medicines: a research roadmap (2014) (259)
- Tissue clearing and its applications in neuroscience (2020) (254)
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation (2016) (252)
- LRP1 is a master regulator of tau uptake and spread (2020) (217)
- Leptin regulates the reward value of nutrient (2011) (217)
- Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping (2015) (200)
- Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli (2017) (175)
- Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice (2020) (175)
- A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice (2020) (175)
- Systemic AAV vectors for widespread and targeted gene delivery in rodents (2019) (168)
- The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress (2018) (165)
- Single-molecule RNA detection at depth by hybridization chain reaction and tissue hydrogel embedding and clearing (2016) (164)
- Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways (2016) (155)
- The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) (148)
- Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow (2017) (131)
- Archaerhodopsin Variants with Enhanced Voltage Sensitive Fluorescence in Mammalian and Caenorhabditis elegans Neurons (2014) (122)
- The Serotonergic Raphe Promote Sleep in Zebrafish and Mice (2019) (107)
- Viral Strategies for Targeting the Central and Peripheral Nervous Systems. (2018) (104)
- Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics (2019) (100)
- Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies (2018) (98)
- Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. (2019) (92)
- Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling (2016) (86)
- AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset (2021) (83)
- Hydrogel-Tissue Chemistry: Principles and Applications. (2018) (82)
- Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types (2020) (82)
- Directed evolution of a far-red fluorescent rhodopsin (2014) (79)
- Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization (2017) (77)
- Witten Conditioning Cholinergic Interneurons Control Local Circuit Activity and Cocaine (2011) (77)
- Microbiota regulate social behaviour via stress response neurons in the brain (2021) (74)
- Optogenetic Delay of Status Epilepticus Onset in an In Vivo Rodent Epilepsy Model (2013) (64)
- Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex (2019) (63)
- Two-Photon Microscopy with a Double-Wavelength Metasurface Objective Lens. (2018) (61)
- Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light (2017) (56)
- Enhancer viruses for combinatorial cell-subclass-specific labeling (2021) (52)
- Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. (2017) (52)
- Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. (2015) (46)
- Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins (2017) (41)
- Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy (2018) (40)
- Molecular basis of astrocyte diversity and morphology across the CNS in health and disease (2022) (39)
- Genomic Reconstruction of an Uncultured Hydrothermal Vent Gammaproteobacterial Methanotroph (Family Methylothermaceae) Indicates Multiple Adaptations to Oxygen Limitation (2015) (34)
- TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotectionupon Ischemic Stroke in Mice (2019) (34)
- Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors. (2016) (34)
- RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations (2019) (30)
- Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK (2021) (28)
- Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics (2019) (26)
- Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators (2019) (25)
- Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1 (2019) (23)
- Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems (2022) (23)
- Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes via Single-Cell RNA Sequencing (2021) (21)
- Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research (2018) (21)
- Adeno-Associated Virus Toolkit to Target Diverse Brain Cells. (2022) (21)
- Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling (2019) (19)
- Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice (2021) (18)
- Epigenetic landscape and AAV targeting of human neocortical cell classes (2019) (16)
- Human embryo polarization requires PLC signaling to mediate trophectoderm specification (2021) (15)
- Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation (2020) (14)
- Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice (2021) (14)
- Controlling neuronal activity. (2008) (13)
- The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody (2021) (11)
- Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids (2020) (11)
- Glutamate in primary afferents is required for itch transmission (2021) (8)
- Widespread and targeted gene expression by systemic AAV vectors: Production, purification, and administration (2018) (7)
- Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? (2017) (7)
- LRP1 is a master regulator of tau uptake and spread (2020) (6)
- Intravenous gene transfer throughout the brain of infant Old World primates using AAV (2022) (6)
- Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery (2021) (5)
- Systemic AAV vectors for widespread and targeted gene delivery in rodents (2019) (5)
- Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context (2021) (5)
- Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice (2021) (5)
- Mechanism of cell polarisation and first lineage segregation in the human embryo (2020) (5)
- Expanding the brain researcher's toolkit (2020) (4)
- Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses (2021) (4)
- Publisher Correction: Tissue clearing and its applications in neuroscience (2020) (4)
- Multi-Wavelength Analytical Ultracentrifugation of Biopolymer Mixtures and Interactions (2021) (4)
- Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice (2021) (4)
- Global Collaboration, Learning from Other Fields (2016) (4)
- Neuroscience: Fluorescent boost for voltage sensors (2016) (4)
- Structural basis of receptor usage by the engineered capsid AAV-PHP.eB (2022) (3)
- Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes (2021) (3)
- Dynamics of Retrieval Strategies for Remote Memories (2011) (3)
- Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types (2020) (3)
- Overriding sleep (2017) (3)
- Dorsal raphe dopamine neurons signal motivational salience dependent on internal and external states (2020) (3)
- Structure-Guided Rational Design of Adeno-Associated Viral Capsids with Expanded Sizes (2020) (3)
- Immediate Responses to Ambient Light in the Suprachiasmatic Nucleus Reveal Distinct Activity Profiles and Retinal Connectivity for SCN VIP Neurons (2022) (2)
- Time-reversed ultrasonically encoded (TRUE) focusing for deep-tissue optogenetic modulation (2018) (2)
- AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset (2021) (2)
- Lee et al. reply (2010) (2)
- Spatial transcriptomics for profiling the tropism of viral vectors in tissues. (2023) (2)
- Optogenetic Control of Neural Activity with Time-Reversed Ultrasound Encoded Light (2017) (2)
- Adeno-Associated Viral Gene Therapy Using PHP.B:NPC1 Ameliorates Disease Phenotype in Mouse Model of Niemann-Pick C1 Disease (2017) (2)
- A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice (2022) (2)
- Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid (2022) (2)
- Neuronal activity sensing and modulation with Archers (2014) (1)
- Dysregulated mammalian estrus cycle rescued by timed activation of VIP neurons in the circadian pacemaker and late afternoon light exposure (2023) (1)
- RecV recombinase system for spatiotemporally controlled light-inducible genomic modifications (2019) (1)
- Advances in Neurotechniques: Methods that Reveal the Structure and Function of the Brain (2014) (1)
- Optogenetic Functional Magnetic Resonance Imaging ( ofMRI ) : Genetically Targeted In Vivo Brain Circuit Mapping (2009) (1)
- Paracrine delivery of therapeutic biologics for cancer (2019) (0)
- Brain Circuit Mapping with Optogenetic Functional Magnetic Resonance Imaging (ofMRI) (2010) (0)
- Driving the Next Steps with Technology (2019) (0)
- Engineering Cell Type Specific Delivery Vectors for Noninvasive Modulation of Brain Circuits and Behaviors (2018) (0)
- Transduction Profiles of Engineered Adeno-Associated Viral Capsids in Mouse and Marmoset (2020) (0)
- Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates (2023) (0)
- CRISPR-clear imaging of melanin-rich B16-derived solid tumors (2023) (0)
- Developing AAV Vectors for More Efficient and Selective Gene Expression in Specific Cell Types of the Nervous System Following Systemic Delivery (2018) (0)
- Deeper Insights in Transparent Animals (2014) (0)
- On Brain Circuits and Tools: Switches for Locomotion, Reward, and a Viral-based Approach to Non-invasive Whole-brain Cargo Delivery (2017) (0)
- Rhodopsin Engineering through Structure-Guided Recombination (2016) (0)
- Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies (2019) (0)
- Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs. (2022) (0)
- Engineered AAVs for Non-Invasive Functional Transgene Expression in Rodent and Non-Human Primate Central and Peripheral Nervous Systems (2022) (0)
- Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice (2020) (0)
- Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology (2022) (0)
- Fast, accurate ranking of engineered proteins by receptor binding propensity using structural modeling (2023) (0)
- Multiplexed-CREATE Selection Yields AAV Vectors Targeting Different Cell Types of the Central Nervous System Following Systemic Delivery (2019) (0)
- Targeted Neuronal Activation of the Gastrointestinal Tract Shapes the Environment of the Gut in Mice (2021) (0)
- Negative feedback control of neuronal activity by microglia (2020) (0)
- Tools for Anatomical and Functional Analysis of Widely Distributed Brain Networks (2016) (0)
- Gene therapy for the treatment of Niemann-Pick disease type C1: Comparison of AAV9 to a novel serotype, AAV-PHP.B (2018) (0)
- Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system (2023) (0)
- In-Depth Parallel Profiling of Tissue and Cell-Type Tropism of AAV Variants by Single-Cell RNA Sequencing (2020) (0)
- Neurophysiological and Optogenetic Assessment of Brain Networks Involved in Motor Control (2015) (0)
- Bone CLARITY reveals that anti-sclerostin antibody penetrates the lacunar canalicular system in mice under physiological loading conditions (2017) (0)
- 11 Optogenetics to benefit human health: opportunities and challenges (2013) (0)
- Enhanced Efficacy of Gene Therapy Treatment for Niemann-Pick C1 Disease Using a Novel Serotype, AAV-PHP.B (2018) (0)
- Improving light delivery for optogenetics using wavefront shaping (2017) (0)
- Intravenous functional gene transfer throughout the brain of non-human primates using AAV (2023) (0)
- Author response: Human embryo polarization requires PLC signaling to mediate trophectoderm specification (2021) (0)
- Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier (2023) (0)
- RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations (2020) (0)
- Targeted Activation of Enteric Neurons Shapes the Gut Environment of Mice (2020) (0)
- 252. Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System (2016) (0)
- Cloud-based Software for NGS Data Management and Analysis for Directed Evolution of Peptide-Based Delivery Vectors (2020) (0)
- Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer (2023) (0)
- Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation (2020) (0)
- Building a Toolbox of Compact Enhancers for Cell Type-Specific Gene Expression from AAVs in the Primate Brain (2020) (0)
- Evolution and Investigation of Engineered AAV Capsids Exhibiting Enhanced Transduction of the Central Nervous System with or without Murine Strain Specificity (2020) (0)
- Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? (2017) (0)
- Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors (2023) (0)
- Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators (2019) (0)
- Targeting the Rodent Peripheral Nervous System Efficiently and with Greater Specificity through Intravenous Delivery of AAV Capsids Evolved by Multiplexed-CREATE (2020) (0)
- Visualizing the Activity and Anatomy of Brain Circuits: Optogenetic Sensors and Tissue Clearing Approaches (2015) (0)
- Engineered AAVS for CNS Transduction and Peripheral Organ De-Targeting across Species after Systemic Delivery (2019) (0)
- Method for High-Throughput, In Situ Characterization of AAV Variant Pools in Intact Tissue Using Ultrasensitive Sequential FISH (2020) (0)
- Author response: Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1 (2019) (0)
- 275. Development of Universal, Strong Mini- Promoters for Recombinant Adeno-Associated Viral (rAAV) Vectors (2021) (0)
- A Computational and Experimental Platform for Detecting Full Transcriptome Cell Type Tropism of Lowly Expressed Barcoded and Pooled AAV Variants via Single-Cell RNA Sequencing (2020) (0)
- Tissue clearing and its applications in neuroscience (2020) (0)
- Switches for multiple behavioral states and a viral-based approach to non-invasive whole-brain cargo delivery (Conference Presentation) (2017) (0)
- Optogenetic, Tissue Clearing, and Viral Vector Approaches to Understand and Influence Whole‐animal Physiology and Behavior (2018) (0)
- Double-wavelength metasurface objective lens for two-photon microscopy (Conference Presentation) (2019) (0)
- 'Light-Guided Sectioning' for Precise Localization and 3D Visualization of In Situ Optical Implants (2020) (0)
- Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents (2019) (0)
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