William Allen Frazier
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Biology
William Allen Frazier's Degrees
- PhD Biomedical Sciences University of California, San Francisco
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)William Allen Frazier's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009) (1324)
- A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. (1990) (1059)
- Integrin-associated protein (CD47) and its ligands. (2001) (786)
- CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells (1997) (642)
- Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity (1993) (577)
- CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors (2015) (510)
- Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. (2000) (447)
- Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin (*) (1996) (414)
- Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. (1994) (373)
- Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence (1985) (371)
- CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1* (2006) (254)
- Surface components and cell recognition. (1979) (254)
- CD47, a Ligand for the Macrophage Fusion Receptor, Participates in Macrophage Multinucleation* (2000) (246)
- Critical role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis (2008) (235)
- Nerve growth factor and insulin. (1972) (232)
- Thrombspondin Acts via Integrin-associated Protein to Activate the Platelet Integrin αIIbβ3 * (1997) (214)
- The properdin-like type I repeats of human thrombospondin contain a cell attachment site (1991) (214)
- Thrombospondin modulates alpha v beta 3 function through integrin- associated protein (1996) (206)
- Role for SpiC in the development of red pulp macrophages and splenic iron homeostasis (2008) (194)
- Role of Cholesterol in Formation and Function of a Signaling Complex Involving αvβ3, Integrin-Associated Protein (Cd47), and Heterotrimeric G Proteins (1999) (187)
- The Thrombospondin Receptor Integrin-associated Protein (CD47) Functionally Couples to Heterotrimeric Gi * (1999) (185)
- Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells (1987) (177)
- Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. (2008) (174)
- The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. (1985) (169)
- Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. (1995) (162)
- Identification of integrin α 3 β 1 as a neuronal thrombospondin receptor mediating neurite outgrowth (1995) (161)
- Properties of the specific binding of 125I-nerve growth factor to responsive peripheral neurons. (1974) (154)
- A monoclonal antibody against human thrombospondin inhibits platelet aggregation. (1985) (153)
- Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. (1984) (153)
- The Thrombospondin Receptor CD47 (IAP) Modulates and Associates with α2β1 Integrin in Vascular Smooth Muscle Cells (1998) (151)
- Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. (2005) (149)
- Heparin-binding peptides from thrombospondins 1 and 2 contain focal adhesion-labilizing activity. (1993) (148)
- CD47 Mediates Killing of Breast Tumor Cells via Gi-Dependent Inhibition of Protein Kinase A (2004) (130)
- Purification and comparison of two developmentally regulated lectins from Dictyostelium discoideum. Discoidin I and II. (1975) (125)
- Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses* (2009) (119)
- Integrin-Associated Protein Stimulates α2β1-Dependent Chemotaxis via GI-Mediated Inhibition of Adenylate Cyclase and Extracellular-Regulated Kinases (1999) (118)
- Increasing Survival of Ischemic Tissue by Targeting CD47 (2007) (112)
- In vitro assembly of Neurospora assimilatory nitrate reductase from protein subunits of a Neurospora mutant and the xanthine oxidizing or aldehyde oxidase systems of higher animals. (1970) (112)
- Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy (1987) (112)
- Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma. (2015) (111)
- Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. (2000) (108)
- Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. (1986) (106)
- Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. (2009) (103)
- Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing (1985) (101)
- Thrombospondin-1: a physiological regulator of nitric oxide signaling. (2008) (98)
- Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery. (1999) (97)
- Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems. (1992) (97)
- Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in 2β1-Mediated Platelet Activation (1999) (92)
- Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins. (1994) (90)
- Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. (1997) (87)
- Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to Ischemia (2007) (86)
- The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A1 (2003) (85)
- Interaction of nerve growth factor with surface membranes: biological competence of insolubilized nerve growth factor. (1973) (85)
- Thrombospondin Modulates OLv~ 3 Function through Integrin-associated Protein (1996) (83)
- Topography of mouse 2.5S nerve growth factor. Reactivity of tyrosine and tryptophan. (1973) (82)
- CD47 regulates bone mass and tumor metastasis to bone. (2009) (81)
- Formation of assimilatory nitrate reductase by in vitro inter-cistronic complementation in Neurospora crassa. (1970) (79)
- Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin. (1993) (79)
- Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration1 (2006) (78)
- Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts (2008) (77)
- Purification, characterization, and partial amino acid sequence of nerve growth factor from cobra venom. (1976) (76)
- Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. (1995) (75)
- Cell membranes, methods and reviews (1983) (72)
- Properties and specificity of binding sites for 125I-nerve growth factor in embryonic heart and brain. (1974) (72)
- Erratum: Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species (Journal of Clinical Investigation (2000) 105 (1095-1108)) (2000) (69)
- Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling. (2008) (69)
- CD47 Augments Fas/CD95-mediated Apoptosis* (2005) (69)
- The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. (1998) (67)
- Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation. (1999) (60)
- Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. (2011) (59)
- Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region (1989) (59)
- Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin. (1986) (58)
- Gene Silencing of CD47 and Antibody Ligation of Thrombospondin-1 Enhance Ischemic Tissue Survival in a Porcine Model: Implications for Human Disease (2008) (57)
- Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype. (1998) (56)
- Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. (2005) (55)
- Tissue specific expression of alternatively spliced Murine PECAM‐1 isoforms (1999) (55)
- CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions (2013) (54)
- Mechanism of action of nerve growth factor and cyclic AMP on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation. (1973) (50)
- Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin. (1985) (50)
- CD47: a new target in cardiovascular therapy. (2008) (48)
- Comparison of normal and tumorigenic endothelial cells: differences in thrombospondin production and responses to transforming growth factor-beta. (1994) (48)
- Human keratinocytes synthesize and secrete the extracellular matrix protein, thrombospondin. (1987) (48)
- Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain. (1974) (47)
- Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. (1985) (45)
- Thrombospondin‐1 Regulates Bone Homeostasis Through Effects on Bone Matrix Integrity and Nitric Oxide Signaling in Osteoclasts (2015) (44)
- Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases. (2000) (44)
- Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. (1984) (41)
- Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding (2019) (41)
- Cholesterol-independent Interactions with CD47 Enhance αvβ3 Avidity* (2004) (40)
- Isolation of the fibrinogen-binding region of platelet thrombospondin. (1984) (40)
- Repression of thrombospondin-1 expression, a natural inhibitor of angiogenesis, in polyoma middle T transformed NIH3T3 cells. (1996) (37)
- Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. (1992) (37)
- Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy (2015) (37)
- Transient increase in intracellular pH during Dictyostelium differentiation (1984) (34)
- Cell attachment activity of the carboxyl-terminal domain of human thrombospondin expressed in Escherichia coli. (1991) (33)
- Photoaffinity labeling of cyclic-AMP- and AMP-binding proteins differentiating Dictyostelium discoideum cells. (1979) (33)
- An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. (2003) (33)
- Comparison of the nerve growth factor proteins from cobra venom (Naja naja) and mouse submaxillary gland. (1976) (32)
- Subcellular localization of nerve growth factor receptors. Thirteen-day chick embryo brain. (1976) (32)
- [3H]Methotrexate as a ligand for the folate receptor of Dictyostelium discoideum. (1981) (30)
- Association of the cyclic AMP chemotaxis receptor with the detergent- insoluble cytoskeleton of Dictyostelium discoideum (1984) (30)
- CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model (2015) (30)
- CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model (2014) (28)
- Purification and characterization of multiple species (isolectins) of a slime mold lectin implicated in intercellular adhesion. (1979) (26)
- Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies (2012) (25)
- The Thrombospondin Receptor CD 47 ( IAP ) Modulates and Associates with a 2 b 1 Integrin in Vascular Smooth Muscle Cells (1998) (24)
- Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages. (2009) (24)
- Slime mold lectins. (1982) (24)
- Thrombospondins: from structure to therapeutics (2008) (23)
- [24] Isolation and characterization of thrombospondin (1987) (22)
- Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. (2008) (22)
- Discoidin I-membrane interactions II. Discoidin I binds to and agglutinates negatively charged phospholipid vesicles (1982) (21)
- Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. (2004) (21)
- Subcellular localization of nerve growth factor receptors. Developmental correlations in chick embryo brain. (1976) (20)
- Preparation of 125I-discoidin I and the properties of its binding to Dictyostelium discoideum cells. (1980) (19)
- Hormone receptors as regulators of hormone action. (1977) (19)
- Imaging of CD47 Expression in Xenograft and Allograft Tumor Models (2013) (19)
- Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays. (2000) (19)
- Characterization of the platelet agglutinating activity of thrombospondin. (1985) (19)
- Reciprocal periodicity in cyclic AMP binding and phosphorylation of differentiating Dictyostelium discoideum cells. (1977) (18)
- The role of cell surface components in the morphogenesis of the cellular slime molds (1976) (17)
- Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21Cip1/WAF1. (1999) (17)
- Reconstitution of discoidin hemagglutination activity by lipid extracts of Dictyostelium discoideum cells. (1979) (16)
- Properties of the oscillatory cAMP binding component of Dictyostelium discoideum cells and isolated plasma membranes. (1979) (14)
- Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody (2016) (13)
- pH‐Dependent self‐association of the Src homology 2 (SH2) domain of the Src homologous and collagen‐like (SHC) protein (1996) (13)
- [31] Dictyostelium discoideum agglutinins (discoidins I and II) (1978) (12)
- Pearl Harbor : a tomato variety resistant to spotted wilt in Hawaii (1945) (12)
- A study of some factors associated with the occurrence of cracks in the tomato fruit (1933) (11)
- Plastic mulches for horticultural crops (1957) (11)
- Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21(Cip1/WAF1). (1999) (10)
- Isolation and characterization of thrombospondin. (1987) (10)
- Nerve growth factor and insulin: evidence of similarities in structure, function, and mechanism of action. (1974) (10)
- A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 integrins in a bent, resting conformation. (2008) (9)
- Discoidin I-membrane interactions III. Interaction of discoidin I with living Dictyostelium discoideum cells (1982) (9)
- Purification and characterization of a membrane-associated cAMP-binding protein from developing Dictyostelium discoideum. (1984) (9)
- Purification of a high-affinity discoidin I-binding proteoglycan from axenic Dictyostelium discoideum growth medium. (1981) (8)
- Chemotactic Transduction in the Cellular Slime Molds (1984) (8)
- Dictyostelium calmodulin: affinity isolation and characterization. (1983) (8)
- Discoidin I-membrane interactions I. Discoidin I binds to two types of receptor on fixed Dictyostelium discoideum cells (1982) (8)
- Studies on the Inheritance of Stemphylium Resistance in Tomatoes (1949) (7)
- Nerve growth factor: structure and mechanism of action. (1975) (7)
- Structure of human thrombospondin: complete amino acid sequence derived from cDNA. (1987) (7)
- Miniprep DNA isolation for automated sequencing of multiple samples. (1997) (6)
- Direct use of synthetic peptides for antiserum production. (1998) (6)
- Nerve growth factor. (1974) (6)
- Solubilization and hydrophobic immobilization assay of a cAMP binding protein from Dictyostelium discoideum plasma membranes. (1981) (5)
- Seven new Tomatoes-varieties resistant to spotted wilt, Fusarium wilt, and gray leaf spot. (1950) (4)
- HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in a2b1-Mediated Platelet Activation (1999) (4)
- A New Target in Cardiovascular Therapy (2008) (4)
- Correlation between certain seedling and mature plant characters in rhubarb. (1960) (4)
- Direct and enzyme-mediated photoaffinity labeling of membrane-associated actin in Dictyostelium discoideum. (1979) (4)
- Chemotactic Receptors of Dictyostelium discoideum (1982) (3)
- Active Peptide Sequences in the Cell Binding Domain of Thrombospondins (1993) (3)
- Field behavior and processing characteristics of Blue Lake beans (1950) (3)
- Specific Interaction of Nerve Growth Factor with Receptors in the Central and Peripheral Nervous Systems (1976) (2)
- Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p 21 Cip 1 / WAF 1 (1999) (2)
- Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 (2010) (2)
- Thrombospondins and Their Receptors: Evolving Functions (2013) (2)
- Fertilization of lettuce on alkaline-calcareous soils : soil and plant studies. (1940) (2)
- A Naturally Occurring Extracellular R-! Clasp Contributes to Stabilization of ! 3 Integrins in a Bent , Resting Conformation † (2008) (2)
- Dictyostelium discoideum agglutinins (discoidins I and II). (1978) (2)
- Structural studies of 2.5 S mouse submaxillary gland nerve growth factor. (1972) (1)
- Abstract 2: Phosphorylation of BNIP3 is a switch between life and death in cancer cells (2015) (1)
- CD47 as a potential target for molecular imaging (2012) (1)
- Photoaffinity labeling of cyclic-AMP-and AMP-binding proteins of differentiating Dictyostelium discoideum cells ( chemotactic receptor / cytoplasmic cyclic-AMP-binding proteins / 8-azido-cyclic AMP ) (1)
- Preliminary results of fertilizer placement for lettuce in raised irrigated beds. (1940) (1)
- Structure and Function of Thrombospondins (1992) (1)
- Sulfur placement in the fertilization of alkaline soils. (1940) (1)
- 198. Blocking Thrombospondin-1-CD47 Signaling Enhances Tissue Survival to Ischemia in a Porcine Model (2008) (1)
- Platelets in Storage: Altered S-Nitrosothiol Metabolism and Decreased Responsiveness May Be Related. (2008) (1)
- In Vivo Applications of Morpholino Oligonucleotides (2008) (1)
- Vegetable crops improvement (1954) (0)
- Field behavior and processing characteristics of sweet corn hybrids grown in 1953-54 (1956) (0)
- Selective Targeting of Rod Photoreceptors in Inflammation-Induced Neurodegeneration (2015) (0)
- Multiple Lectins in Two Species of Cellular Slime Molds (1976) (0)
- Quality studies on pole and bush beans, 1958 (1959) (0)
- Inhibition of Protein Kinase A -Dependent i of T Cells: Heterotrimeric G The Mechanism of CD47-Dependent Killing (2003) (0)
- STRUCTURE-FUNCTION RELATIONSHIPS OF NERVE GROWTH FACTOR AND INSULIN (1976) (0)
- ASSOCIATION BETWEEN WAXY POD COLOR AND SOME MORPHOLOGICAL CHARACTERS IN THE BUSH SNAP BEAN (1965) (0)
- Inhibition of Protein Kinase A-Dependentiof T Cells : Heterotrimeric G The Mechanism of CD 47-Dependent Killing (2003) (0)
- Oregon 4, 5, 6, and 14 Carrot Breeding Lines1 (1980) (0)
- Abstract 1521: ApoE-Null Mice Lacking CD36/FAT are Protected Against Neointimal Hyperplasia and Have an Altered Autoimmune Response to Hyperlipidemia (2006) (0)
- CD47 blockade improves survival after transplantation of steatotic liver allografts (2014) (0)
- CD47 Blockade Improves Hepatic Function In An Ex Vivo Model Of Ischemia/Reperfusion (2011) (0)
- Attenuation of hepatic ischemia-reperfusion injury through CD47 blockade in vivo (2012) (0)
- A monoclonal antibody against human thrombospondin inhibits platelet aggregation ( domain / epitope / amino acid sequence (0)
- Dual-Function Anti-CD47mAbs Induce Tumor Cell Death and Promote Phagocytosis Resulting in Enhanced in Vivo Efficacy (2014) (0)
- antithrombotic activity of nitric oxide/cGMP signaling Thrombospondin-1 stimulates platelet aggregation by blocking the (2013) (0)
- Thrombospondin-1 regulates blood pressure and cardiac response (2008) (0)
- Thrombospondin-1 Stimulates Platelet Aggregation by Blocking the Anti- thrombotic Activity of Nitric Oxide/cGMP Signaling Running head: TSP1 blocks the anti-thrombotic activity of NO (2007) (0)
- Mapping Functional Domains of Human Platelet Thrombospondin with Electro-Blotting and High Sensitivity Sequencing (1987) (0)
- PSS136 - Thrombospondin-1 Stimulates Macrophage Reactive Oxygen Species Generation via CD47: a Novel Signaling Event in Atherosclerosis (2013) (0)
- Analysis of the virus disease complex that reduces yields of Blue Lake beans in Oregon (1956) (0)
- P8. Osteoclast dysfunction in CD47−/− mice suppresses metastatic tumor burden and osteolysis (2008) (0)
- Novel class of duocarmycin analogs: Design, synthesis and biological evaluation of achiral seco-CBI analogs and CC-1065. (2005) (0)
- Role of Cholesterol in Formation and Function of a Signaling Complex Involving (cid:97) v (cid:98) 3, Integrin-associated Protein (CD47), and Heterotrimeric G Proteins (1999) (0)
- Methotrexate as a ligand for the folate receptor of Dictyostelium discoideum ( folate deaminase / chemotaxis / chemoldnesis / developmental regulation / receptor coupling ) (0)
- 807 – STRUCTURE-FUNCTION RELATIONSHIPS OF NERVE GROWTH FACTOR AND INSULIN (1977) (0)
- β3 Integrins and Integrin-Associated Protein Regulate Leukocyte Function (1997) (0)
- Cellular recognition : proceedings of the UCLA symposium held at Keystone, Colorado, March 1-8, 1981 (1982) (0)
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