William Allen Frazier

William Allen Frazier's AcademicInfluence.com Rankings

Biology

#12415

World Rank

#15890

Historical Rank

Immunology

#828

World Rank

#851

Historical Rank

biology Degrees

Download Badge

Biology

William Allen Frazier's Degrees

PhD Biomedical Sciences University of California, San Francisco
Bachelors Biology Stanford University

Similar Degrees You Can Earn

Best Online Bachelor's in Biology 2026

Why Is William Allen Frazier Influential?

(Suggest an Edit or Addition)

(See a Problem?)

William Allen Frazier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009) (1324)
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. (1990) (1059)
Integrin-associated protein (CD47) and its ligands. (2001) (786)
CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells (1997) (642)
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity (1993) (577)
CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors (2015) (510)
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. (2000) (447)
Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin (*) (1996) (414)
Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. (1994) (373)
Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence (1985) (371)
CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1* (2006) (254)
Surface components and cell recognition. (1979) (254)
CD47, a Ligand for the Macrophage Fusion Receptor, Participates in Macrophage Multinucleation* (2000) (246)
Critical role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis (2008) (235)
Nerve growth factor and insulin. (1972) (232)
Thrombspondin Acts via Integrin-associated Protein to Activate the Platelet Integrin αIIbβ3 * (1997) (214)
The properdin-like type I repeats of human thrombospondin contain a cell attachment site (1991) (214)
Thrombospondin modulates alpha v beta 3 function through integrin- associated protein (1996) (206)
Role for SpiC in the development of red pulp macrophages and splenic iron homeostasis (2008) (194)
Role of Cholesterol in Formation and Function of a Signaling Complex Involving αvβ3, Integrin-Associated Protein (Cd47), and Heterotrimeric G Proteins (1999) (187)
The Thrombospondin Receptor Integrin-associated Protein (CD47) Functionally Couples to Heterotrimeric Gi * (1999) (185)
Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells (1987) (177)
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. (2008) (174)
The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. (1985) (169)
Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. (1995) (162)
Identification of integrin α 3 β 1 as a neuronal thrombospondin receptor mediating neurite outgrowth (1995) (161)
Properties of the specific binding of 125I-nerve growth factor to responsive peripheral neurons. (1974) (154)
A monoclonal antibody against human thrombospondin inhibits platelet aggregation. (1985) (153)
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. (1984) (153)
The Thrombospondin Receptor CD47 (IAP) Modulates and Associates with α2β1 Integrin in Vascular Smooth Muscle Cells (1998) (151)
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. (2005) (149)
Heparin-binding peptides from thrombospondins 1 and 2 contain focal adhesion-labilizing activity. (1993) (148)
CD47 Mediates Killing of Breast Tumor Cells via Gi-Dependent Inhibition of Protein Kinase A (2004) (130)
Purification and comparison of two developmentally regulated lectins from Dictyostelium discoideum. Discoidin I and II. (1975) (125)
Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses* (2009) (119)
Integrin-Associated Protein Stimulates α2β1-Dependent Chemotaxis via GI-Mediated Inhibition of Adenylate Cyclase and Extracellular-Regulated Kinases (1999) (118)
Increasing Survival of Ischemic Tissue by Targeting CD47 (2007) (112)
In vitro assembly of Neurospora assimilatory nitrate reductase from protein subunits of a Neurospora mutant and the xanthine oxidizing or aldehyde oxidase systems of higher animals. (1970) (112)
Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy (1987) (112)
Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma. (2015) (111)
Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. (2000) (108)
Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. (1986) (106)
Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. (2009) (103)
Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing (1985) (101)
Thrombospondin-1: a physiological regulator of nitric oxide signaling. (2008) (98)
Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery. (1999) (97)
Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems. (1992) (97)
Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in 2β1-Mediated Platelet Activation (1999) (92)
Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins. (1994) (90)
Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. (1997) (87)
Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to Ischemia (2007) (86)
The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A1 (2003) (85)
Interaction of nerve growth factor with surface membranes: biological competence of insolubilized nerve growth factor. (1973) (85)
Thrombospondin Modulates OLv~ 3 Function through Integrin-associated Protein (1996) (83)
Topography of mouse 2.5S nerve growth factor. Reactivity of tyrosine and tryptophan. (1973) (82)
CD47 regulates bone mass and tumor metastasis to bone. (2009) (81)
Formation of assimilatory nitrate reductase by in vitro inter-cistronic complementation in Neurospora crassa. (1970) (79)
Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin. (1993) (79)
Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration1 (2006) (78)
Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts (2008) (77)
Purification, characterization, and partial amino acid sequence of nerve growth factor from cobra venom. (1976) (76)
Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. (1995) (75)
Cell membranes, methods and reviews (1983) (72)
Properties and specificity of binding sites for 125I-nerve growth factor in embryonic heart and brain. (1974) (72)
Erratum: Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species (Journal of Clinical Investigation (2000) 105 (1095-1108)) (2000) (69)
Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling. (2008) (69)
CD47 Augments Fas/CD95-mediated Apoptosis* (2005) (69)
The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. (1998) (67)
Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation. (1999) (60)
Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. (2011) (59)
Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region (1989) (59)
Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin. (1986) (58)
Gene Silencing of CD47 and Antibody Ligation of Thrombospondin-1 Enhance Ischemic Tissue Survival in a Porcine Model: Implications for Human Disease (2008) (57)
Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype. (1998) (56)
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. (2005) (55)
Tissue specific expression of alternatively spliced Murine PECAM‐1 isoforms (1999) (55)
CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions (2013) (54)
Mechanism of action of nerve growth factor and cyclic AMP on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation. (1973) (50)
Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin. (1985) (50)
CD47: a new target in cardiovascular therapy. (2008) (48)
Comparison of normal and tumorigenic endothelial cells: differences in thrombospondin production and responses to transforming growth factor-beta. (1994) (48)
Human keratinocytes synthesize and secrete the extracellular matrix protein, thrombospondin. (1987) (48)
Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain. (1974) (47)
Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. (1985) (45)
Thrombospondin‐1 Regulates Bone Homeostasis Through Effects on Bone Matrix Integrity and Nitric Oxide Signaling in Osteoclasts (2015) (44)
Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases. (2000) (44)
Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. (1984) (41)
Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding (2019) (41)
Cholesterol-independent Interactions with CD47 Enhance αvβ3 Avidity* (2004) (40)
Isolation of the fibrinogen-binding region of platelet thrombospondin. (1984) (40)
Repression of thrombospondin-1 expression, a natural inhibitor of angiogenesis, in polyoma middle T transformed NIH3T3 cells. (1996) (37)
Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. (1992) (37)
Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy (2015) (37)
Transient increase in intracellular pH during Dictyostelium differentiation (1984) (34)
Cell attachment activity of the carboxyl-terminal domain of human thrombospondin expressed in Escherichia coli. (1991) (33)
Photoaffinity labeling of cyclic-AMP- and AMP-binding proteins differentiating Dictyostelium discoideum cells. (1979) (33)
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. (2003) (33)
Comparison of the nerve growth factor proteins from cobra venom (Naja naja) and mouse submaxillary gland. (1976) (32)
Subcellular localization of nerve growth factor receptors. Thirteen-day chick embryo brain. (1976) (32)
[3H]Methotrexate as a ligand for the folate receptor of Dictyostelium discoideum. (1981) (30)
Association of the cyclic AMP chemotaxis receptor with the detergent- insoluble cytoskeleton of Dictyostelium discoideum (1984) (30)
CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model (2015) (30)
CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model (2014) (28)
Purification and characterization of multiple species (isolectins) of a slime mold lectin implicated in intercellular adhesion. (1979) (26)
Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies (2012) (25)
The Thrombospondin Receptor CD 47 ( IAP ) Modulates and Associates with a 2 b 1 Integrin in Vascular Smooth Muscle Cells (1998) (24)
Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages. (2009) (24)
Slime mold lectins. (1982) (24)
Thrombospondins: from structure to therapeutics (2008) (23)
[24] Isolation and characterization of thrombospondin (1987) (22)
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. (2008) (22)
Discoidin I-membrane interactions II. Discoidin I binds to and agglutinates negatively charged phospholipid vesicles (1982) (21)
Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. (2004) (21)
Subcellular localization of nerve growth factor receptors. Developmental correlations in chick embryo brain. (1976) (20)
Preparation of 125I-discoidin I and the properties of its binding to Dictyostelium discoideum cells. (1980) (19)
Hormone receptors as regulators of hormone action. (1977) (19)
Imaging of CD47 Expression in Xenograft and Allograft Tumor Models (2013) (19)
Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays. (2000) (19)
Characterization of the platelet agglutinating activity of thrombospondin. (1985) (19)
Reciprocal periodicity in cyclic AMP binding and phosphorylation of differentiating Dictyostelium discoideum cells. (1977) (18)
The role of cell surface components in the morphogenesis of the cellular slime molds (1976) (17)
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21Cip1/WAF1. (1999) (17)
Reconstitution of discoidin hemagglutination activity by lipid extracts of Dictyostelium discoideum cells. (1979) (16)
Properties of the oscillatory cAMP binding component of Dictyostelium discoideum cells and isolated plasma membranes. (1979) (14)
Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody (2016) (13)
pH‐Dependent self‐association of the Src homology 2 (SH2) domain of the Src homologous and collagen‐like (SHC) protein (1996) (13)
[31] Dictyostelium discoideum agglutinins (discoidins I and II) (1978) (12)
Pearl Harbor : a tomato variety resistant to spotted wilt in Hawaii (1945) (12)
A study of some factors associated with the occurrence of cracks in the tomato fruit (1933) (11)
Plastic mulches for horticultural crops (1957) (11)
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21(Cip1/WAF1). (1999) (10)
Isolation and characterization of thrombospondin. (1987) (10)
Nerve growth factor and insulin: evidence of similarities in structure, function, and mechanism of action. (1974) (10)
A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 integrins in a bent, resting conformation. (2008) (9)
Discoidin I-membrane interactions III. Interaction of discoidin I with living Dictyostelium discoideum cells (1982) (9)
Purification and characterization of a membrane-associated cAMP-binding protein from developing Dictyostelium discoideum. (1984) (9)
Purification of a high-affinity discoidin I-binding proteoglycan from axenic Dictyostelium discoideum growth medium. (1981) (8)
Chemotactic Transduction in the Cellular Slime Molds (1984) (8)
Dictyostelium calmodulin: affinity isolation and characterization. (1983) (8)
Discoidin I-membrane interactions I. Discoidin I binds to two types of receptor on fixed Dictyostelium discoideum cells (1982) (8)
Studies on the Inheritance of Stemphylium Resistance in Tomatoes (1949) (7)
Nerve growth factor: structure and mechanism of action. (1975) (7)
Structure of human thrombospondin: complete amino acid sequence derived from cDNA. (1987) (7)
Miniprep DNA isolation for automated sequencing of multiple samples. (1997) (6)
Direct use of synthetic peptides for antiserum production. (1998) (6)
Nerve growth factor. (1974) (6)
Solubilization and hydrophobic immobilization assay of a cAMP binding protein from Dictyostelium discoideum plasma membranes. (1981) (5)
Seven new Tomatoes-varieties resistant to spotted wilt, Fusarium wilt, and gray leaf spot. (1950) (4)
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in a2b1-Mediated Platelet Activation (1999) (4)
A New Target in Cardiovascular Therapy (2008) (4)
Correlation between certain seedling and mature plant characters in rhubarb. (1960) (4)
Direct and enzyme-mediated photoaffinity labeling of membrane-associated actin in Dictyostelium discoideum. (1979) (4)
Chemotactic Receptors of Dictyostelium discoideum (1982) (3)
Active Peptide Sequences in the Cell Binding Domain of Thrombospondins (1993) (3)
Field behavior and processing characteristics of Blue Lake beans (1950) (3)
Specific Interaction of Nerve Growth Factor with Receptors in the Central and Peripheral Nervous Systems (1976) (2)
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p 21 Cip 1 / WAF 1 (1999) (2)
Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 (2010) (2)
Thrombospondins and Their Receptors: Evolving Functions (2013) (2)
Fertilization of lettuce on alkaline-calcareous soils : soil and plant studies. (1940) (2)
A Naturally Occurring Extracellular R-! Clasp Contributes to Stabilization of ! 3 Integrins in a Bent , Resting Conformation † (2008) (2)
Dictyostelium discoideum agglutinins (discoidins I and II). (1978) (2)
Structural studies of 2.5 S mouse submaxillary gland nerve growth factor. (1972) (1)
Abstract 2: Phosphorylation of BNIP3 is a switch between life and death in cancer cells (2015) (1)
CD47 as a potential target for molecular imaging (2012) (1)
Photoaffinity labeling of cyclic-AMP-and AMP-binding proteins of differentiating Dictyostelium discoideum cells ( chemotactic receptor / cytoplasmic cyclic-AMP-binding proteins / 8-azido-cyclic AMP ) (1)
Preliminary results of fertilizer placement for lettuce in raised irrigated beds. (1940) (1)
Structure and Function of Thrombospondins (1992) (1)
Sulfur placement in the fertilization of alkaline soils. (1940) (1)
198. Blocking Thrombospondin-1-CD47 Signaling Enhances Tissue Survival to Ischemia in a Porcine Model (2008) (1)
Platelets in Storage: Altered S-Nitrosothiol Metabolism and Decreased Responsiveness May Be Related. (2008) (1)
In Vivo Applications of Morpholino Oligonucleotides (2008) (1)
Vegetable crops improvement (1954) (0)
Field behavior and processing characteristics of sweet corn hybrids grown in 1953-54 (1956) (0)
Selective Targeting of Rod Photoreceptors in Inflammation-Induced Neurodegeneration (2015) (0)
Multiple Lectins in Two Species of Cellular Slime Molds (1976) (0)
Quality studies on pole and bush beans, 1958 (1959) (0)
Inhibition of Protein Kinase A -Dependent i of T Cells: Heterotrimeric G The Mechanism of CD47-Dependent Killing (2003) (0)
STRUCTURE-FUNCTION RELATIONSHIPS OF NERVE GROWTH FACTOR AND INSULIN (1976) (0)
ASSOCIATION BETWEEN WAXY POD COLOR AND SOME MORPHOLOGICAL CHARACTERS IN THE BUSH SNAP BEAN (1965) (0)
Inhibition of Protein Kinase A-Dependentiof T Cells : Heterotrimeric G The Mechanism of CD 47-Dependent Killing (2003) (0)
Oregon 4, 5, 6, and 14 Carrot Breeding Lines1 (1980) (0)
Abstract 1521: ApoE-Null Mice Lacking CD36/FAT are Protected Against Neointimal Hyperplasia and Have an Altered Autoimmune Response to Hyperlipidemia (2006) (0)
CD47 blockade improves survival after transplantation of steatotic liver allografts (2014) (0)
CD47 Blockade Improves Hepatic Function In An Ex Vivo Model Of Ischemia/Reperfusion (2011) (0)
Attenuation of hepatic ischemia-reperfusion injury through CD47 blockade in vivo (2012) (0)
A monoclonal antibody against human thrombospondin inhibits platelet aggregation ( domain / epitope / amino acid sequence (0)
Dual-Function Anti-CD47mAbs Induce Tumor Cell Death and Promote Phagocytosis Resulting in Enhanced in Vivo Efficacy (2014) (0)
antithrombotic activity of nitric oxide/cGMP signaling Thrombospondin-1 stimulates platelet aggregation by blocking the (2013) (0)
Thrombospondin-1 regulates blood pressure and cardiac response (2008) (0)
Thrombospondin-1 Stimulates Platelet Aggregation by Blocking the Anti- thrombotic Activity of Nitric Oxide/cGMP Signaling Running head: TSP1 blocks the anti-thrombotic activity of NO (2007) (0)
Mapping Functional Domains of Human Platelet Thrombospondin with Electro-Blotting and High Sensitivity Sequencing (1987) (0)
PSS136 - Thrombospondin-1 Stimulates Macrophage Reactive Oxygen Species Generation via CD47: a Novel Signaling Event in Atherosclerosis (2013) (0)
Analysis of the virus disease complex that reduces yields of Blue Lake beans in Oregon (1956) (0)
P8. Osteoclast dysfunction in CD47−/− mice suppresses metastatic tumor burden and osteolysis (2008) (0)
Novel class of duocarmycin analogs: Design, synthesis and biological evaluation of achiral seco-CBI analogs and CC-1065. (2005) (0)
Role of Cholesterol in Formation and Function of a Signaling Complex Involving (cid:97) v (cid:98) 3, Integrin-associated Protein (CD47), and Heterotrimeric G Proteins (1999) (0)
Methotrexate as a ligand for the folate receptor of Dictyostelium discoideum ( folate deaminase / chemotaxis / chemoldnesis / developmental regulation / receptor coupling ) (0)
807 – STRUCTURE-FUNCTION RELATIONSHIPS OF NERVE GROWTH FACTOR AND INSULIN (1977) (0)
β3 Integrins and Integrin-Associated Protein Regulate Leukocyte Function (1997) (0)
Cellular recognition : proceedings of the UCLA symposium held at Keystone, Colorado, March 1-8, 1981 (1982) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With William Allen Frazier?

William Allen Frazier is affiliated with the following schools:

Oregon State University

William Allen Frazier's Academic­Influence.com Rankings