William Brewster Pratt

William Brewster Pratt's AcademicInfluence.com Rankings

Biology

#7233

World Rank

#10126

Historical Rank

Molecular Biology

#813

World Rank

#833

Historical Rank

Biochemistry

#986

World Rank

#1097

Historical Rank

biology Degrees

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Biology

William Brewster Pratt's Degrees

PhD Biochemistry Stanford University
Bachelors Chemistry University of California, Berkeley

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William Brewster Pratt's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Steroid receptor interactions with heat shock protein and immunophilin chaperones. (1997) (1745)
Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery 1 (2003) (1487)
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. (2005) (1049)
The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. (1993) (616)
The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors (1998) (458)
Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. (1985) (398)
The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. (1997) (369)
Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. (1989) (346)
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. (1993) (307)
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. (2004) (294)
Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery (1997) (279)
Molybdate inhibition of glucocorticoid receptor inactivation and transformation. (1979) (272)
Protein Phosphatase 5 Is a Major Component of Glucocorticoid Receptor·hsp90 Complexes with Properties of an FK506-binding Immunophilin* (1997) (263)
The Anticancer Drugs (1979) (254)
Chaperoning of glucocorticoid receptors. (2006) (254)
Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus* (2001) (244)
Role of molecular chaperones in steroid receptor action. (2004) (243)
The Tetratricopeptide Repeat Domain of Protein Phosphatase 5 Mediates Binding to Glucocorticoid Receptor Heterocomplexes and Acts as a Dominant Negative Mutant* (1996) (242)
Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin. (1985) (240)
Evidence for a Mechanism of Repression of Heat Shock Factor 1 Transcriptional Activity by a Multichaperone Complex* (2001) (227)
Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor. (1987) (217)
A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex. (1988) (217)
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage (2010) (212)
The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase* (1997) (208)
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. (2015) (201)
Different Regions of the Immunophilin FKBP52 Determine Its Association with the Glucocorticoid Receptor, hsp90, and Cytoplasmic Dynein* (1999) (193)
Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation (*) (1996) (189)
Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery (1997) (187)
The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor (*) (1995) (180)
Stepwise Assembly of a Glucocorticoid Receptor·hsp90 Heterocomplex Resolves Two Sequential ATP-dependent Events Involving First hsp70 and Then hsp90 in Opening of the Steroid Binding Pocket* (2000) (178)
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation (2012) (176)
A Model of Protein Targeting Mediated by Immunophilins and Other Proteins That Bind to hsp90 via Tetratricopeptide Repeat Domains* (1996) (172)
The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins. (1990) (172)
The Role of DnaJ-like Proteins in Glucocorticoid Receptor·hsp90 Heterocomplex Assembly by the Reconstituted hsp90·p60·hsp70 Foldosome Complex* (1998) (172)
Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90. (1990) (171)
A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37. (1999) (167)
Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton. (1998) (167)
Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone* (2005) (166)
Neuronal Nitric-oxide Synthase Is Regulated by the hsp90-based Chaperone System in Vivo * (1999) (164)
Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90. (1994) (164)
Reconstitution of the Steroid Receptor·hsp90 Heterocomplex Assembly System of Rabbit Reticulocyte Lysate* (1996) (160)
Glucocorticoid receptor inactivation under cell-free conditions. (1977) (159)
The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts* (2008) (159)
Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells. (1983) (158)
Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex. (1990) (155)
Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus. (1997) (154)
Transformation of glucocorticoid and progesterone receptors to the DNA‐binding state (1987) (153)
Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. (1991) (153)
Hsp90-binding Immunophilins Link p53 to Dynein During p53 Transport to the Nucleus* (2004) (150)
The effect of glucocorticoids on protein and nucleic acid synthesis in mouse fibroblasts growing in vitro. (1966) (140)
Activation of thymocyte glucocorticoid receptors to the steroid binding form. The roles of reduction agents, ATP, and heat-stable factors. (1979) (136)
Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation, and translocation. (1984) (134)
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. (2008) (130)
p50 cdc37 Binds Directly to the Catalytic Domain of Raf as Well as to a Site on hsp90 That Is Topologically Adjacent to the Tetratricopeptide Repeat Binding Site* (1998) (130)
Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. (1995) (129)
Evidence for Glucocorticoid Receptor Transport on Microtubules by Dynein* (2004) (128)
Androgen Receptor Acetylation Site Mutations Cause Trafficking Defects, Misfolding, and Aggregation Similar to Expanded Glutamine Tracts* (2004) (126)
The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90 (*) (1995) (124)
Evidence that dephosphorylation inactivates glucocorticoid receptors. (1977) (123)
Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain. (2002) (121)
The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein. (1985) (120)
Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. (1993) (120)
The Antimicrobial Drugs (1986) (119)
Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. A possible steroid receptor for growth inhibition. (1970) (114)
Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation* (2004) (114)
Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts (1990) (112)
Hsp90-binding immunophilins in plants: the protein movers. (2001) (112)
ATP-dependent activation of L cell glucocorticoid receptors to the steroid binding form. (1979) (111)
Evidence that the 90-kilodalton heat shock protein is associated with tubulin-containing complexes in L cell cytosol and in intact PtK cells. (1988) (107)
Chaperone functions of the heat shock proteins associated with steroid receptors. (1994) (107)
Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro. (1989) (106)
The Hsp Organizer Protein Hop Enhances the Rate of but Is Not Essential for Glucocorticoid Receptor Folding by the Multiprotein Hsp90-based Chaperone System* (2000) (104)
Control of steroid receptor function and cytoplasmic‐nuclear transport by heat shock proteins (1992) (103)
All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a "foldosome". (1994) (100)
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. (2006) (98)
In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90. (1990) (98)
The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex* (2003) (96)
Inhibition of Glucocorticoid Receptor Nucleocytoplasmic Shuttling by Okadaic Acid Requires Intact Cytoskeleton* (1999) (95)
Studies with Purified Chaperones Advance the Understanding of the Mechanism of Glucocorticoid Receptor–hsp90 Heterocomplex Assembly (1998) (95)
Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation* (2010) (92)
Differential Effects of the hsp70-binding Protein BAG-1 on Glucocorticoid Receptor Folding by the hsp90-based Chaperone Machinery* (1999) (90)
Monovalent cation selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90. (1992) (90)
Differential Responsivity of the Hypothalamic‐Pituitary‐Adrenal Axis to Glucocorticoid Negative‐Feedback and Corticotropin Releasing Hormone in Rats Undergoing Morphine Withdrawal: Possible Mechanisms Involved in Facilitated and Attenuated Stress Responses (2001) (89)
Binding of immunophilins to the 90 kDa heat shock protein (hsp90) via a tetratricopeptide repeat domain is a conserved protein interaction in plants. (1996) (88)
Steady-state level of the specific glucocorticoid binding component in mouse fibroblasts. (1972) (86)
Stoichiometry, Abundance, and Functional Significance of the hsp90/hsp70-based Multiprotein Chaperone Machinery in Reticulocyte Lysate* (2001) (85)
Inactivation of glucocorticoid-binding capacity by protein phosphatases in the presence of molybdate and complete reactivation of dithiothreitol. (1982) (85)
Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. (1992) (82)
Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90. (1991) (81)
Animal and plant cell lysates share a conserved chaperone system that assembles the glucocorticoid receptor into a functional heterocomplex with hsp90. (1996) (81)
Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. (1994) (80)
Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor. (1991) (80)
Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton. (1996) (80)
Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase* (2004) (78)
Independent Functions of hsp90 in Neurotransmitter Release and in the Continuous Synaptic Cycling of AMPA Receptors (2004) (77)
Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. (2012) (77)
The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor. (1994) (77)
Lack of effects of copper gluconate supplementation. (1985) (77)
Interaction of the glucocorticoid receptor with the Mr 90,000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation. (1989) (75)
hsp90 Is Required for Heme Binding and Activation of Apo-Neuronal Nitric-oxide Synthase (2002) (71)
FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. (1993) (71)
Glucocorticoid receptor phosphorylation, transformation, and DNA binding. (1987) (69)
Regulation of Glucocorticoid Receptor Function through Assembly of a Receptor‐Heat Shock Protein Complex a (1993) (69)
Glucocorticoid receptor activation and inactivation in cultured human lymphocytes. (1981) (68)
Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a nonrandom manner throughout all planes of the nucleus. (1991) (67)
Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells. (1989) (66)
Localization of phosphorylation sites with respect to the functional domains of the mouse L cell glucocorticoid receptor. (1988) (66)
The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein? (1993) (65)
Cisplatin Induces Bmi1 and Enhances the Stem Cell Fraction in Head and Neck Cancer (2015) (65)
Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain. (1990) (64)
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. (2000) (62)
A model of glucocorticoid receptor unfolding and stabilization by a heat shock protein complex (1992) (62)
Molecular chaperoning of steroid hormone receptors. (1996) (62)
Cyclophilin-A Is Bound through Its Peptidylprolyl Isomerase Domain to the Cytoplasmic Dynein Motor Protein Complex* (2004) (61)
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. (2004) (61)
Inactivation of glucocorticoid receptors in cell-free preparations of rat liver. (1977) (60)
All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. (2002) (60)
Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex. (1990) (57)
Binding of hsp90 to the Glucocorticoid Receptor Requires a Specific 7-Amino Acid Sequence at the Amino Terminus of the Hormone-binding Domain* (1998) (56)
The kinetics of glucocorticoid binding to the soluble specific binding protein of mouse fibroblasts. (1975) (54)
Untreated congenital hip dysplasia in the Navajo. (1982) (53)
Visualization and Mechanism of Assembly of a Glucocorticoid Receptor·Hsp70 Complex That Is Primed for Subsequent Hsp90-dependent Opening of the Steroid Binding Cleft* (2003) (53)
The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor. (1987) (52)
Specific binding of glucocorticoids in vitro in the soluble fraction of mouse fibroblasts. (1972) (49)
Chemotherapy of infection (1977) (48)
The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98-100 kdalton steroid binding phosphoprotein and a 90 kdalton nonsteroid-binding phosphoprotein that is part of the murine heat-shock complex. (1986) (48)
Characteristics of an endogenous glucocorticoid receptor stabilizing factor. (1982) (48)
Molybdate permits resolution of untransformed glucocorticoid receptors from the transformed state. (1981) (47)
The Seven Amino Acids (547–553) of Rat Glucocorticoid Receptor Required for Steroid and Hsp90 Binding Contain a Functionally Independent LXXLL Motif That Is Critical for Steroid Binding* (1999) (47)
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. (2005) (47)
The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. (1994) (46)
[39] Glucocorticoid receptor thiols andsteroid-binding activity (1995) (45)
Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex (1992) (45)
The mechanism of glucocorticoid effects in fibroblasts. (1978) (45)
The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal. (1992) (44)
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes. (2001) (43)
Effect of glucocorticoids on hexose uptake by mouse fibroblasts in vitro. (1971) (42)
Use of the Thiol-specific Derivatizing Agent N-Iodoacetyl-3-Iiodotyrosine to Demonstrate Conformational Differences between the Unbound and hsp90-bound Glucocorticoid Receptor Hormone Binding Domain (*) (1996) (42)
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. (2009) (42)
Reactivation of thymocyte glucocorticoid receptors in a cell-free system. (1977) (41)
Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state. (1990) (41)
Nucleotide Binding States of hsp70 and hsp90 during Sequential Steps in the Process of Glucocorticoid Receptor·hsp90 Heterocomplex Assembly* (2002) (40)
A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex. (1992) (40)
Hallucinogens and Drosophila: linking serotonin receptor activation to behavior (2002) (40)
Mutations at Positions 547–553 of Rat Glucocorticoid Receptors Reveal That hsp90 Binding Requires the Presence, but Not Defined Composition, of a Seven-amino Acid Sequence at the Amino Terminus of the Ligand Binding Domain* (2002) (39)
Characterization and partial purification of the specific glucocorticoid-binding component from mouse fibroblasts. (1971) (39)
The Role of hsp90 in Heme-dependent Activation of Apo-neuronal Nitric-oxide Synthase* (2004) (39)
Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor. (1993) (38)
Demonstration that the 90-kilodalton heat shock protein is bound to the glucocorticoid receptor in its 9S nondeoxynucleic acid binding form. (1987) (38)
A Conserved Proline in the hsp90 Binding Region of the Glucocorticoid Receptor Is Required for hsp90 Heterocomplex Stabilization and Receptor Signaling* (1998) (38)
THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO (1970) (37)
Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin. (1983) (36)
Hepatic glucocorticoid receptors and the H–2 locus (1978) (36)
Spondylolysis and associated spondylolisthesis in Eskimo and Athabascan populations. (1990) (35)
Untreated acetabular dysplasia of the hip in the Navajo. A 34 year case series followup. (1999) (35)
Phosphorylation of L-cell glucocorticoid receptors in immune complexes: evidence that the receptor is not a protein kinase. (1986) (34)
Glucocorticoid receptor structure and the initial events in signal transduction. (1990) (34)
Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination* (2011) (33)
Hydrogen peroxide stabilizes the steroid-binding state of rat liver glucocorticoid receptors by promoting disulfide bond formation. (1988) (31)
ArticleHDAC 6 Regulates Hsp 90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor (2005) (29)
Evidence that the endogenous heat-stable glucocorticoid receptor stabilizing factor is a metal component of the untransformed receptor complex. (1988) (27)
Destabilization of the Epidermal Growth Factor Receptor (EGFR) by a Peptide That Inhibits EGFR Binding to Heat Shock Protein 90 and Receptor Dimerization*♦ (2013) (27)
Evidence that the hormone-binding domain of the mouse glucocorticoid receptor directly represses DNA binding activity in a major portion of receptors that are "misfolded" after removal of hsp90. (1992) (26)
Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor. (1988) (26)
Nutritional status of orthopedic patients with surgical complications. (1981) (26)
CHAPTER 12 – Inactivation, Activation, and Stabilization of Glucocorticoid Receptors (1984) (26)
Glucocorticoid receptor thiols and steroid-binding activity. (1995) (25)
Regulation of glucocorticoid receptor ligand-binding activity by the hsp90/hsp70-based chaperone machinery. (2003) (24)
Fungemia secondary to gastrointestinal Mucor indicus infection. (2006) (24)
The active transport of cortisol by mouse fibroblasts growing in vitro. (1968) (24)
Evidence for a phospholipid requirement in the specific binding of glucocorticoids to receptors of fibroblasts and thymic lymphocytes. (1976) (24)
Nucleic acid synthesis in intact nuclei isolated from mouse fibroblasts. Characterization of the system and effects of glucocorticoids. (1969) (24)
Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts. (2014) (24)
A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases (2014) (22)
Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases (2019) (21)
ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation (2016) (19)
Selective molybdate-directed covalent modification of sulfhydryl groups in the steroid-binding versus the DNA-binding domain of the glucocorticoid receptor. (1990) (18)
Glucocorticoid receptor stabilization: relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2. (1983) (18)
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. (2011) (18)
The effect of cortisol, administered in vivo, on the in vitro incorporation of DNA and RNA precursors by rat thymus cells. (1967) (17)
Small-Colony Variants of Staphylococcus aureus (2010) (17)
Ability of various members of the hsp70 family of chaperones to promote assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90 (1996) (15)
Association of the transformed glucocorticoid receptor with a cytoskeletal protein complex (1992) (14)
The endogenous heat-stable glucocorticoid receptor stabilizing factor and the H-2 locus. (1982) (13)
Purification and preliminary characterization of a macromolecular inhibitor of glucocorticoid receptor binding to DNA. (1985) (13)
C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination* (2010) (12)
Energy-dependent conversion of transformed cytosolic glucocorticoid receptors from soluble to particulate-bound form. (1992) (12)
Localization of the ∼12 kDa Mr discrepancy in gel migration of the mouse glucocorticoid receptor to the major phosphorylated cyanogen bromide fragment in the transactivating domain (1993) (11)
FUNDAMENTALS OF CHEMOTHERAPY (1974) (11)
The heat-stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease. (1987) (11)
Elevated Hair Copper Level in Idiopathic Scoliosis: Preliminary Observations (1980) (11)
Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery (2018) (11)
Effect of Steroids on the Activity of DNA‐Dependent RNA‐Polymerase (1965) (10)
The relationship between glucocorticoid receptor binding to Hsp90 and receptor function. (1990) (10)
The kinetics of specific glucocorticoid binding in rat thymus cytosol: evidence for the existence of multiple binding states. (1975) (9)
The Functional Relevance of the Heteromeric Structure of Corticosteroid Receptors a (1994) (8)
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts (2020) (8)
Purification of the endogenous glucocorticoid receptor stabilizing factor. (1991) (8)
Synthesis and biological action of two glucocorticoid alkylating agents. (1977) (8)
Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors (1994) (7)
Glucocorticoid receptor inactivation and activation by phosphorylation mechanisms. (1979) (6)
Laboratory testing of bolts and screws in cancellous bone. (1989) (5)
Heat stress protects the perfused rabbit heart from complement-mediated injury. (1996) (5)
The active transport of cortisol by mouse fibroblasts growing in vitro. (1968) (5)
DNA-binding and non-DNA-binding forms of the transformed glucocorticoid receptor (1992) (5)
Speculations on the Role of the 90 kDa Heat Shock Protein in Glucocorticoid Receptor Transport and Function (1989) (4)
Murine glucocorticoid receptors and the H-2 locus--a reappraisal. (1984) (4)
Endosymbionts as a source of cytoplasmic satellite deoxyribonucleic acid. (1968) (4)
Targeting Proteostasis Through the Protein Quality Control Function of the Hsp90/Hsp70-based Chaperone Machinery for Treatment of Adult Onset Neurodegenerative Diseases (2015) (3)
Effects of glucocorticoids on nucleic acid synthesis in intact nuclei isolated from mouse fibroblasts. (1969) (3)
Interaction of the glucocorticoid receptor with the M(r) 90,000 heat shock protein (1989) (3)
The Hsp90 Chaperone Machinery Acts at Protein Folding Clefts to Regulate Both Signaling Protein Function and Protein Quality Control (2007) (3)
Localization of the approximately 12 kDa M(r) discrepancy in gel migration of the mouse glucocorticoid receptor to the major phosphorylated cyanogen bromide fragment in the transactivating domain. (1993) (3)
Elevation of hair copper in idiopathic scoliosis. A follow-up report. (1984) (3)
Small 32P-labeled components of L cells that coelute with the molybdate-stabilized glucorticoid receptor during purification (1984) (3)
Lack of effects of copper gluconate (1985) (2)
Reconstitution of the Multiprotein Complex of pp 6 OSr " , hsp 90 , and p 50 in a Cell-free System * (2001) (2)
Treatment of back pain with copper supplementation (1985) (2)
Evidence that removal of an endogenous metal that stabilizes the untransformed glucocorticoid receptor in cytosol allows ligand-independent receptor transformation. (1989) (2)
Inhibition of Glucocorticoid Receptor Conversion to the DNA-Binding State and Inhibition of Subunit Dissociation (1987) (1)
Point Mutations in the 90‐kDa Heat Shock Protein Binding Region of the Glucocorticoid Receptor Affect the Functional Characteristics of the Receptor a (1995) (1)
EFFECTS OF MOLYBDATE AND ENDOGENOUS INHIBITORS ON (1984) (1)
ATP dependent reactivation of glucocorticoid receptors in L cells (1978) (1)
Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery (2011) (1)
Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases (2019) (0)
Effects of glucocorticoids on nucleic acid synthesis in mouse lymphoma cells growing in vitro and on nuclei isolated from these cells. (1970) (0)
neuroprotective treatment of protein folding diseases A model in which heat shock protein 90 targets protein-folding clefts : Rationale for a new approach to (2014) (0)
945 – AN ENZYMATIC EXPLANATION FOR THE RAPID INACTIVATION OF GLUCOCORTICOID RECEPTORS IN CELL-FREE PREPARATIONS (1978) (0)
Rapid and reversible alteration of glucocorticoid receptor activity in cultured human (IM-9) lymphocytes (1979) (0)
1034 – THE KINETICS OF BINDING OF STEROIDS TO THE SOLUBLE GLUCOCORTICOID RECEPTOR OF L 929 MOUSE FIBROBLASTS AND RAT THYMOCYTES (1977) (0)
[Enzyme induction with steroids in Pseudomonas testosteroni]. (1965) (0)
SYNTHESIS AND BIOLOGICAL ACTION OF TWO GLUCOCORTICOID ALKYLATING AGENTS (1977) (0)
The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control (2012) (0)
Purification and characterization of the macromolecular inhibitor of glycocorticoid receptor translocation (1984) (0)
Untreated Congenital Hip Dysplasia (2006) (0)
Phosphorylation of the glucocorticoid receptor (1984) (0)
947 – REACTIVATION OF INACTIVATED THYMOCYTE GLUCOCORTICOID RECEPTORS BY ADDITION OF DITHIOTHREITOL AND HEAT STABLE FACTORS FROM LIVER AND FIBROBLASTS (1978) (0)
The Y-glutamyl bond in chick embryo collagen. (1964) (0)
At the Cutting Edge Interaction of hsp 90 with steroid receptors : organizing some diverse observations and presenting the newest concepts (2002) (0)
Properties of an endogenous glucocorticoid receptor stabilizing factor (1981) (0)
Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase (2022) (0)
The role of an endogenous heat stable factor(s) in stabilizing glucocorticoid receptors (1981) (0)
Does the binding of glucocorticoids to the L cell receptor involve a two step mechanism (1974) (0)

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