William Herman Prusoff

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Chemistry

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William Herman Prusoff's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. (1973) (12101)
Synthesis and biological activities of iododeoxyuridine, an analog of thymidine. (1959) (308)
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus. (1987) (235)
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent. (1989) (187)
Synthesis and biological activity of several amino analogues of thymidine. (1978) (169)
Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication. (1989) (166)
Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses. (1987) (111)
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus. (1978) (109)
Studies of excretion (and absorption) of Co60 labeled vitamin B12 in pernicious anemia. (1952) (104)
Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol (1989) (99)
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). (1988) (97)
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro. (1987) (96)
Studies in the mouse of the pharmacology of 5-iododeoxyuridine, an analogue of thymidine. (1960) (96)
The PC12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs. (1991) (86)
Synthesis of 5-(dihydroxyboryl)-2'-deoxyuridine and related boron-containing pyrimidines (1985) (85)
Nucleoside analogs with antiviral activity. (1976) (84)
A REVIEW OF SOME ASPECTS OF 5-IODODEOXYURIDINE AND AZAURIDINE. (1963) (77)
Structure and conformation of 3′-azido-3′-deoxythymidine (AZT), an inhibitor of the HIV (AIDS) virus (1987) (69)
The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity. (1983) (69)
Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. (1993) (68)
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs. (1976) (67)
Specific herpes simplex virus-induced incorporation of 5-iodo-5'-amino-2',5'-dideoxyuridine into deoxyribonucleic acid. (1976) (66)
Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme. (1979) (66)
Anti-viral Activities of Several Iodinated Pyrimidine Deoxyribonucleosides (1962) (66)
Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine (1975) (65)
Effect of 5-iodo-2'-deoxyuridine on the biosynthesis of phosphorylated derivatives of thymidine. (1962) (63)
RECENT ADVANCES IN CHEMOTHERAPY OF VIRAL DISEASES (1967) (59)
THE COMPARATIVE UPTAKE OF I-125-LABELED 5-IODO-2'-DEOXYURIDINE AND THYMIDINE-H3 INTO TISSUES OF MICE BEARING HEPATOMA-129. (1965) (58)
Mouse ascites Sarcoma 180 deoxythymidine kinase. General properties and inhibition studies. (1974) (57)
Deoxyribonucleotide metabolism in Herpes simplex virus infected HeLa cells. (1975) (56)
Incorporation of iododeoxyuridine into the deoxyribonucleic acid of mouse Ehrlich-ascites-tumor cells in vivo. (1960) (55)
Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells. (1982) (55)
Inhibition of the growth of mouse leukemia cells in culture by 5-iododeoxyuridine. (1959) (55)
Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides. (2010) (54)
CELLULAR AND ANTIVIRAL EFFECTS OF HALOGENATED DEOXYRIBONUCLEOSIDES * (1965) (51)
Studies on the mechanism of action of 5-iododeoxyuridine, an analog of thymidine. (1960) (48)
Design of anti-HIV compounds: from nucleoside to nucleoside 5'-triphosphate analogs. Problems and perspectives. (2000) (47)
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues. (1980) (46)
Mouse ascites sarcoma 180 thymidylate kinase. General properties, kinetic analysis, and inhibition studies. (1973) (46)
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells infected with mutant strains of herpes simplex virus (1979) (46)
3'-Deoxythymidin-2'-ene permeation of human lymphocyte H9 cells by nonfacilitated diffusion. (1991) (45)
Further studies on the inhibition of nucleic acid biosynthesis by azathymidine and by deoxyadenosine. (1959) (42)
Non-utilization of radioactive iodinated uracil, uridine, and orotic acid by animal tissues in vivo. (1953) (41)
Pharmacology of viruses. (1970) (40)
Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4T): a potent and selective inhibitor of human immunodeficiency virus. (1988) (40)
Effect of the deoxyriboside of 6-azathymine (azathymidine) on the biosynthesis of deoxyribonucleic acid by bone marrow and neoplastic cells (in vitro). (1956) (39)
The effect of 5-iododeoxyuridine upon the growth of some transplantable rodent tumors. (1960) (37)
Halogenated Pyrimidine Deoxyribonucleosides (1975) (37)
Studies on the mechanism of action of 6-azathymine. I. Biosynthesis of the deoxyriboside. (1955) (37)
Potential mechanisms of action of antiviral agents. (1973) (37)
Unusual structural features of 2',3'-dideoxycytidine, an inhibitor of the HIV (AIDS) virus. (1988) (36)
Antiviral iodinated pyrimidine deoxyribonucleosides: 5-iodo-2'-deoxyuridine; 5-iodo-2'-deoxycytidine; 5-iodo-5'-amino-2',5'-dideoxyuridine. (1979) (36)
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides. (1978) (36)
Synthesis and properties of boron and silicon substituted uracil or 2′-deoxyuridine (1979) (34)
The incorporation of 5-iodo-5'-amino-2',5-dideoxyuridine and 5-iodo-2'-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure. (1980) (33)
A study of the antiviral mechanism of action of 2-deoxy-D-glucose: normally glycosylated proteins are not strictly required for herpes simplex virus attachment but increase viral penetration and infectivity. (1982) (32)
Studies on the biochemical pharmacology of 5-iodo-2'-deoxycytidine in vitro and in vivo. (1962) (31)
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride. (1991) (30)
Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus. (1989) (30)
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine. (1991) (30)
1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine. A Highly Potent and Selective Anti-HIV Agent. (1989) (30)
Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides. (1993) (30)
Studies on the mechanism of action of azathymine. III. Relationship between incorporation into deoxypentose nucleic acid and inhibition. (1957) (30)
Phosphorylation of 5-iodo-5'-amino-2',5',dideoxyuridine by herpes simplex virus type 1 encoded thymidine kinase. (1979) (29)
Photochemistry of Proteins and Nucleic Acids (1964) (29)
Alteration of ultraviolet sensitivity of thymidine kinase by allosteric regulators, normal substrates, and a photo-affinity label, 5-iodo-2'-deoxyuridine, a metbolic analog of thymidine. (1972) (27)
PHOTOCHEMISTRY OF IODOURACIL. II. EFFECTS OF SULFUR COMPOUNDS, ETHANOL AND OXYGEN. (1965) (27)
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives. (1979) (27)
A new rapid assay for measuring deoxycytidylate- and deoxythymidylate-kinase activities. (1974) (26)
A novel intramolecular hydrogen bond in the crystal structure of 5-hydroxymethyl-2'-deoxyuridine, an antiviral and antineoplastic nucleoside. Conformational analysis of the deoxyribose ring (1980) (24)
Studies on the metabolism of thymine-2-C14 by the rat. (1954) (23)
Potential targets for antiviral chemotherapy. (1986) (23)
Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine. (1976) (23)
Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice. (1980) (23)
5-Bromo-2'-deoxycytidine (BCDR). II. Studies with murine neoplastic cells in culture and in vitro. (1961) (23)
Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides. (1986) (22)
Effect of 3'-amino-3'-deoxythymidine on L1210 and P388 leukemias in mice. (1982) (21)
Inhibition by 5-Iododeoxyuridine of the Oncogenic Effects of Adenovirus Type 12 in Hamsters (1963) (21)
RECENT STUDIES ON THE ANTIVIRAL AND BIOCHEMICAL PROPERTIES OF 5‐HALO‐5'‐AMINO‐DEOXYRIBONUCLEOSIDES * (1977) (20)
Physical and biological consequences of incorporation of antiviral agents into virus DNA. (1984) (19)
Concentration of intrinsic factor and vitamin B12-binding activities of fractions of desiccated hog stomach. (1953) (19)
Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine. (1992) (19)
A synopsis of recent investigations of 5-iodo-2'-deoxyuridine. (1960) (19)
The ability of phage containing 5-iodo-2'-deoxyuridine-subsituted deoxyribonucleic acid to induce enzymes. (1968) (19)
Low-temperature reversal of the ultraviolet photochemical reaction product of 2'-deoxyuridine. (1963) (19)
PHOTOCHEMISTRY OF IODOURACIL. I. PHOTOPRODUCTS OBTAINED IN WATER. (1965) (18)
Purification of deoxythymidine kinase by preparative disc gel electrophoresis and the effects of various halogenated nucleoside triphosphates on its enzymatic activity. (1971) (18)
Studies on the mechanism of action 6-azathymine. II. Azathymine deoxyriboside, a microbial inhibitor. (1956) (18)
Molecular basis of the antineoplastic activity of 3'-amino-3'-deoxythymidine. (1984) (18)
5'-Amino-5'-deoxythymidine: synthesis, specific phosphorylation by herpesvirus thymidine kinase, and stability to pH of the enzymically formed diphosphate derivative (1980) (18)
5-iodo-2'-deoxyuridine 5'-triphosphate, an allosteric inhibitor of deoxycytidylate deaminase. (1968) (18)
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine. (1978) (17)
5-Iodo-5'-amino-2',5'-dideoxyuridine-5'-N'-triphosphate. Synthesis, chemical properties, and effect on Escherichia coli thymidine kinase activity. (1976) (17)
Regulation of thymidine kinase activity by 5-iodo-2'-deoxyuridine 5'-triphosphate and deoxythymidine 5'-triphosphate. (1970) (17)
Inhibition of HIV-1 protease by a boron-modified polypeptide. (2000) (16)
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL ANALOGS OF THYMIDINE * (1975) (16)
Photochemical studies and ultraviolet sensitization of Escherichia coli thymidylate kinase by various halogenated substrate analogs. (1976) (16)
Decrease of sensitivity to ultraviolet radiation of Streptococcus faecalis grown in media supplemented with 6-azathymine, an analog of thymine. (1962) (16)
Biological investigations of 6-azathymine, a thymine analog. (1954) (15)
Reversal of the cytotoxicity of 3'-amino-3'-deoxythymidine by pyrimidine deoxyribonucleosides. (1979) (15)
The distribution of 5-hydroxytryptamine and adenosinetriphosphate in cytoplasmic particles of the dog's small intestine. (1960) (15)
Basic biochemical and pharmacological aspects of antiviral agents. (1985) (14)
Synergistic effect of 5'-amino-5'-deoxythymidine and 5-iodo-2'-deoxyuridine against Herpes Simplex virus infections in vitro. (1979) (14)
THE RELATION OF ANTIVIRAL ACTIVITY OF IUdR TO GENE FUNCTION IN PHAGE * (1970) (14)
Effect of 5-Iodo-5′-Amino-2′,5′-Dideoxyuridine on Varicella-Zoster Virus In Vitro (1979) (14)
Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine. (1976) (14)
[45] Thymidine kinase from Escherichia coli (1978) (14)
Studies on a relationship of uracil and cytosine nucleosides to biosynthesis of deoxyribonucleic acid thymine. (1958) (14)
Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells. (1990) (14)
Synthesis and antineoplastic activity of a novel series of phosphoramide mustard analogues of pyrimidine deoxyribonucleosides. (1980) (13)
Effects of nucleoside analogues on the expression of herpes simplex type 1-induced proteins. (1982) (13)
Interaction of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: implications for human immunodeficiency virus drug design. (1998) (13)
Kinetic and photochemical studies of 3-N-methyl-5-iodo-2-'-deoxyuridine. Sensitization of ultraviolet inactivation of thymidine kinase by 3-N-methyl-5-iodo-2'-deoxyuridine and other halogenated analogs of thymidine. (1972) (13)
Synthesis and antiviral evaluation of carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine. (1988) (12)
Basis for the Selective Antiviral and Antitumor Activity of Pyrimidine Nucleoside Analogs (1979) (12)
Kinetic and photochemical studies and alteration of ultraviolet sensitivity of Escherichia coli thymidine kinase by halogenated allosteric regulators and substrate analogues. (1977) (12)
Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay. (1986) (12)
Development of oral HSV-1 infection model in mice. Evaluation of efficacy of 5'-amino-5-iodo-2',5'-dideoxyuridine. (1982) (12)
Studies on the mechanism of cellular sensitization to ultraviolet radiation by halogenated pyrimidines. I. (1962) (12)
Structural Features of 2′,3′-Dideoxy-2′,3′-Didehydrocytidine, A Potent Inhibitor of the HIV (AIDS) Virus (1989) (12)
5'-Amino-5'-deoxythymidine: Topical Therapeutic Efficacy in Ocular Herpes and Systemic Teratogenic and Toxicity Studies (1982) (11)
Enhancement of the anticancer activity of bis(2-chloroethyl)nitrosourea in mice by coadministration of 2'-deoxyuridine, 2'-deoxycytidine, or thymidine. (1987) (11)
Effect of reserpine on the 5-hydroxytryptamine and adenosinetriphosphate of the dog intestinal mucosa. (1961) (11)
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides. (1978) (11)
Approaches to antiviral drug development. (1989) (11)
Studies on the metabolism of thymine and 6-azathymine. (1962) (10)
5-Bromo-2'-deoxycytidine (BCDR). I. Studies on metabolism in vitro and in mice. (1961) (10)
Antitumor activity of the 3'-chloroethylnitrosourea analog of thymidine and the prevention by co-administered thymidine of lethality but not of anticancer activity. (1982) (10)
Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus--HIV-1. (1993) (10)
Overview of the Possible Targets for Viral Chemotherapy (1984) (10)
Synthesis and properties of 1-(3'-dihydroxyboryl-2',3'-dideoxyribosyl)pyrimidines. (2012) (10)
Dissociation of the inhibitory effects of 2-deoxy-D-glucose on Vero cell growth and the replication of herpes simplex virus (1982) (9)
A comparative study of the effect of normal substrates and 5-iodo-2'-deoxyuridine triphosphate, a metabolic analog of thymidine triphosphate, on the inactivation of Escherichia coli deoxyribonucleic acid polymerase I and II by ultraviolet irradiation. (1974) (9)
Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L1210 cells and its relationship to the potentiation of the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea but not of 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine. (1991) (9)
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides (1984) (9)
Studies on the mechanism of action of 6-uracil methyl sulfone in mouse Ehrlich ascites tumor cells in vitro. (1958) (8)
Photosensitivity of 6-azathymine and its effect on the formation of photoproducts of thymine and cytosine. (1967) (8)
Idoxuridine or How It All Began (1988) (8)
Specific protection against the cytotoxicity of a new class of nitrosoureas by pyrimidine deoxyribonucleosides. (1979) (8)
Anti-Viral Activity of Azathymidine and Uracil Methyl Sulphone (1966) (8)
A novel zwitterionic structure and an unusual sugar ring conformation in 5-iodo-5'-amino-2',5'-dideoxyuridine, an antiviral nucleoside (1979) (8)
Studies of the effects of 5-iodo-2'-deoxyuridine on the formation of adenovirus type 2 virions and the synthesis of virus-induced polypeptides. (1979) (8)
5-Iodo-2′-Deoxyuridine (1979) (7)
Synthesis and biological activity of several amino nucleoside-platinum(II) complexes. (1986) (7)
Protective effect of 6-azathymine and 6-azauracil against the lethal effect of ultraviolet irradiation. II. Isolation of thymine photoproducts from the nucleic acids of Streptococcus faecalis. (1967) (7)
Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine. (1993) (6)
Synthesis of (+)-l-[(lα,2α,3β,4α)-2,3-Dihydroxy-4-Hydroxymethyl] -5-Methyl-2,4-(1H, 3H) Pyrimidinedione, the Carbocyclic Analogue of Ara-T (1988) (6)
Effect of 5-Bromouracil on Utilization of Thymidine by Streptococcus faecalis.∗ (1954) (6)
Synthesis and Anticancer Activity of Various 3′-Deoxy Pyrimidine Nucleoside Analogues and Crystal Structure of 1-(3-Deoxy-β-D- threo-pentofuranosyl)cytosine. (1991) (6)
Separation of thymidine and its mono-, di- and tri-phosphate by paper chromatography. (1961) (6)
RECENT STUDIES WITH 5-IODODEOXYURIDINE (IUDR) AND RELATED COMPOUNDS. (1963) (6)
Synthesis and Antiviral Activity of Various 3′-Azido Analogues of Pyrimidine Deoxyribonucleosides Against Human Immunodeficiency Virus (HIV-1, HTLV-III/LAV). (1988) (6)
COMPARISON OF THE LETHAL EFFECT OF 5‐IODOURACIL INCORPORATED INTO BACTERIOPHAGE T4 IN THE PRESENCE AND ABSENCE OF NEAR‐VISIBLE LIGHT (1975) (6)
Pyrimidine Nucleosides with Selective Antiviral Activity (1982) (6)
Effect of thymine ribonucleoside on the metabolism of 125I-5-iodo-2′-deoxyuridine (1966) (6)
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SEVERAL AMINO ANALOGS OF THYMIDINE (1978) (6)
Synthesis and biological activities of chloroethylurea, methylurea, and nitrosourea analogues of N-deacetylmethylthiocolchicine. (1980) (6)
A NOVEL ZWITTERIONIC STRUCTURE AND AN UNUSUAL SUGAR RING CONFORMATION IN 5-IODO-5′-AMINO-2′,5′-DIDEOXYURIDINE, AN ANTIVIRAL NUCLEOSIDE (1979) (6)
Thymidine kinase from Escherichia coli. (1978) (6)
Role of nucleosides in virus and cancer chemotherapy. (1979) (5)
Anti-viral activity of 5,6-dichloro-1-(2'-deoxy-beta-d-ribofuranosyl)benzimidazole and related derivatives. (1968) (5)
The effect of 5-lodo-2′-deoxyuridine 5′-triphosphate, an allosteric inhibitor, on deoxycytidylate deaminase “induced” by herpes simplex virus (1968) (5)
Preparative and analytical high-performance liquid chromatographic methods in the synthesis and analysis of decomposition of nitrosourea nucleosides. (1985) (5)
Synthesis of 3′-CTNU radiolabelled with 14C in the alkylating moiety and 3H in the carbamoylating moiety† (1985) (5)
Effect of incorporation of 5-iodo-2'-deoxyuridine into HSV-1 DNA on virion sensitivity to ultraviolet light. (1987) (5)
Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine. (1986) (5)
The effect of 5-iodo-2'-deoxyuridine and its mono- and triphosphates on some enzymes concerned with the biosynthesis of DNA in cell-free extracts of murine neoplastic cells. (1969) (5)
[3] Isolation of thymine dimers (1967) (5)
The influence of pteroylglutamic acid on nucleic acid synthesis in Lactobacillus casei. (1948) (5)
Inhibition of herpes simplex virus replication by methyl daunosamine (1982) (4)
Synthesis of [2‐14C] 3′‐deoxythymidin‐2′ ‐ENE (d4T) and [5–125I] 3′ ‐azido‐2′, 3′‐dideoxy‐5‐iodouridine: Potent inhibitors of human immunodeficiency virus (HIV‐1) (1989) (4)
Development of Nitrosourea Nucleosides as Anticancer Agents (1984) (4)
Antiviral activity of certain substituted purine and pyrimidine nucleosides (1969) (4)
Studies of the mechanism of resistance to pyrimidines in Streptococcus faecalis. I. An unusual effect of 5-iodouracil and 5-iodo-2'-deoxyuridine. (1963) (4)
Microbiological Activities of Iodoorotic Acid and Iodouridine.∗ (1954) (4)
Multiplicity Reactivation of 5-Iodouracil-Substituted, Nonviable Bacteriophage T4td8 (1975) (4)
Chemotherapy of Ocular Viral Infections and Tumors (1984) (4)
AIU: an antiherpetic drug with low neonatal toxicity in mice. (1979) (4)
Development of Antiviral Drugs (1981) (3)
Inhibitory action of thymine ribonucleoside and other pyrimidine derivatives on the cleavage of 5-iodo-deoxy-uridine by mouse-liver extract. (1970) (3)
An improved synthesis of 6-azathymidine (1978) (3)
Antiviral drugs: modes of action and strategies for therapy. (1981) (3)
SOME BIOLOGICAL AND BIOCHEMICAL PROPERTIES OF 5-IODOCYTOSINE. (1964) (3)
The relationship between the antiviral activity of 5'-amino-5'-deoxythymidine and its incorporation into herpes simplex virus type 1 DNA. (1984) (3)
Experimental Aspects of Antiviral Pharmacology (1988) (3)
RADIOACTIVE IDOXURIDINE ADMINISTERED INTO THE CONJUNCTIVAL SAC OF THE RABBIT. (1965) (3)
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues. (1986) (3)
The effect of 5-iodo-2′-deoxyuridine-5′-triphosphate on DNA polymerase of uninfected and herpes simplex virus infected cells† (1969) (2)
Effect of ultraviolet light on DNA structure in 5-iodo-2'-deoxyuridine-substituted HSV-1 DNA. (1991) (2)
A NOVEL SYNTHESIS AND BIOLOGICAL ACTIVITY OF SEVERAL 5-HALO-5′-AMINO ANALOGS OF DEOXYRIBOPYRIMIDINE NUCLEOSIDES (1978) (2)
Synthesis and Antiviral Activity of Various 3′-Azido, 3′-Amino, 2′,3′- Unsaturated, and 2′,3′-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides Against Retroviruses. (1987) (2)
Comparative analysis of the immunosuppressive properties of two antiviral, iodinated thymidine analogs, 5-iodo-2'-deoxyuridine and 5-iodo-5'-amino-2',5'-dideoxyuridine. (1980) (2)
EFFECT OF DEOXYCYTIDINE ON THE RATE OF BIOSYNTHESIS OF PHOSPHORYLATED DERIVATIVES OF THYMIDINE. (1964) (2)
Molecular basis for treatment of herpesvirus infections (1984) (2)
SYNTHESIS AND ANTIVIRAL ACTIVITY OF 5- AND 5′-SUBSTITUTED THYMIDINE ANALOGS (1976) (2)
The effect of 5-iodouracil on the growth and biosynthetic processes of bacteriophage T4td8 in the absence of light. (1976) (2)
Effect of 6-azathymine on the isolation and properties of deoxyribonucleic acid from Streptococcus faecalis (1967) (2)
DISCUSSION OF THE POSSIBLE MECHANISMS OF ACTION OF 5-IODO-2'-DEOXYURIDINE (IDU,IUDR) AND CHYMOTRYPSIN IN THE TREATMENT OF HERPES SIMPLEX KERATITIS. (1963) (2)
Synthesis and biochemical investigation of thymine-6-carboxylic acid-2-C14. (1954) (2)
Antiviral Drugs, Mode of Action and Chemotherapy of Viral Infections of Man (1977) (2)
Syntheses of [2‐14C] 2,5′‐anhydro‐3′‐azido‐3′‐deoxythymidine and [2‐14C] 2,5′‐anhydro‐3′‐azido‐2′,3′‐dideoxy‐5‐iodouridine: Inhibitors of human immunodeficiency virus (HIV‐1) (1991) (1)
Synthesis of 1-(5-azido-5-deoxy-. beta. -D-arabinofuranosyl)cytosine and 1-(5-amino-5-deoxy-. beta. -D-arabinofuranosyl)cytosine (1975) (1)
Comparative effects of 5'-amino-5'-deoxythymidine, a new antiviral agent, and 5-iodo-2'-deoxyuridine on the immune response of mice. No immunosuppression with 5'-amino-5'-deoxythymidine. (1982) (1)
SYNTHESIS, ANTIVIRAL ACTIVITY, AND MECHANISM OF ACTION OF A NOVEL SERIES OF PYRIMIDINE NUCLEOSIDE ANALOGS (1978) (1)
Alteration of cellular oncogene expression in L1210 cells by a nitrosourea analog of thymidine. (1991) (1)
Synthesis and Anticancer and Antiviral Activities of Various 2′‐ and 3′ ‐Methylidene‐Substituted Nucleoside Analogues and Crystal Structure of 2′‐Deoxy‐2′‐methylidenecytidine Hydrochloride. (1992) (1)
Interaction of 3′‐Deoxythymidin‐2′‐ene Triphosphate (d4TTP) with Reverse Transcriptase from Human Immunodeficiency Virus a (1990) (1)
Effect of 6-azathymine, an analog of thymine, on the urinary excretion of uracil. (1962) (1)
SENSITIVITY OF MONOMERIC AND DIMERIC FORMS OF E. COLI THYMIDINE KINASE TO ULTRAVIOLET RADIATION * (1972) (1)
A NOVEL INTRAMOLECULAR HYDROGEN BOND IN THE CRYSTAL STRUCTURE OF 5-HYDROXYMETHYL-2′-DEOXYURIDINE, AN ANTIVIRAL AND ANTINEOPLASTIC NUCLEOSIDE. CONFORMATIONAL ANALYSIS OF THE DEOXYRIBOSE RING (1980) (1)
Pharmaceutical composition containing (1987) (1)
Additions and Corrections-Synthesis and Antiviral Activity of Various 3'-Azido, 3'-Amino, 2',3'-Unsaturated, and 2',3'-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides against Retroviruses (1987) (1)
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-(HYDROXYMETHYL, AZIDOMETHYL, OR AMINOMETHYL)-2′-DEOXYURIDINE AND RELATED 5′-SUBSTITUTED ANALOGS (1980) (1)
Synthesis of (.+-.)-1-((1α,2α,3β,4α)-2,3-Dihydroxy-4-hydroxymethylcyc# lopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione, the Carbocyclic Analogue of Ara-T. (1988) (0)
Studies on the mechanism of action of 5-iodo-2'-deoxyuridine. Abstr. (1961) (0)
ANTIVIRAL AND ANTINEOPLASTIC ACTIVITIES OF PYRIMIDINE ARABINOSYL NUCLEOSIDES AND THEIR 5′-AMINO DERIVATIVES (1980) (0)
ANTINEOPLASTIC AGENTS. 1. SYNTHESIS AND ANTINEOPLASTIC ACTIVITIES OF CHLOROETHYL- AND METHYLNITROSOUREA ANALOGS OF THYMIDINE (1978) (0)
SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF A NOVEL SERIES OF PHOSPHORAMIDE MUSTARD ANALOGS OF PYRIMIDINE DEOXYRIBONUCLEOSIDES (1981) (0)
Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Technical progress report, June 1, 1974--February 1, 1975 (1975) (0)
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME URONIC ACIDS, URONATES, URONAMIDES, AND URONONITRILES OF PYRIMIDINE NUCLEOSIDES (1979) (0)
Effect of thymidine on uptake, DNA alkylation, and DNA repair in L1210 cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine. (1988) (0)
Inhibition of poly (ADP-ribose) polymerase by various antiviral and anticancer nucleoside analogs (1991) (0)
RECENT ADVANCES IN VIRAL CHEMOTHERAPY (1968) (0)
DISCUSSION (1977) (0)
Book reviews (2004) (0)
A pharmaceutical preparation with 3'-deoxythymidine-2'-ene (3'-deoxy-2 ', 3'-didehydrothymidine) for treating patients with retroviral infections. (1987) (0)
The effect of 5-iodo-2'-deoxyuridine 5'-triphosphate, an allosteric inhibitor, on deoxycytidylate deaminase "induced" by herpes simplex virus. (1968) (0)
The effect of the nitrosourea analog of thymidine, 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine, on Escherichia coli thymidine kinase. (1980) (0)
The effect of 5'-amino-5'-deoxythymidine on the pattern of polyadenylation of herpes simplex virus type 1 ribonucleic acid. (1988) (0)
3'-amino-3'-deoxythymidine Is a potent inhibitor of dna synthesis that effectively inhibits the growth of l1210 leukemia in vitro and in vivo. Abstr. (1979) (0)
S-phase specificity and reversibility of 3'-amino- -2',3'-dideoxycytidine (3'-nh2-dcyd) induced cytotoxicity. Abstr. (1983) (0)
Enhancement of oncogene expression in L1210 cells by a chemotherapeutic agent (1986) (0)
Herpesvirus : clinical, pharmacological, and basic aspects : proceedings of the International Symposium on Herpesvirus held in Tokushima City, Japan, July 27-30, 1981 (1982) (0)
Riboside of 1,2,4-triazine-3,5(2H, 4H)-dione (I; R=H) (6-azauracil), which interupts pyrimidine nucleoside formation by inhibition of orotydylic acid decarboxylase through conversion to its 5'-monophosphate6) in some mutant of microorganisms7,8) or mam- (2010) (0)
Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Final report, June 1, 1974--May 31, 1978 (1978) (0)
Pharmacological considerations of antiviral agents (1984) (0)
Synthesis of pyrimidine and purine di nucleosides potential transition state analogs (1981) (0)
Antiviral agents. (1983) (0)
Mechanism of Uptake of 3′‐Deoxythymidin‐2′‐ene (d4T) in Human Lymphocyte H9 Cells a (1990) (0)
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CHLOROETHYLUREA, METHYLUREA, AND NITROSOUREA ANALOGS OF N-DEACETYLMETHYLTHIOCOLCHICINE (1981) (0)
Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Technical progress report, June 1, 1975--December 22, 1975. [UV radiation] (1976) (0)
5-iodo-5'amino-2',5'-dideoxyuridine(aiu) And 5-iods-2'- -deoxyuridine, (idurd) are cycle-dependent immunosuppres- sives. Abstr. (1979) (0)
Azathymidine, the deoxyriboside of an analogue of thymine: an antagonist of the utilization of thymidine and of the reproduction of certain cells. (1955) (0)
Herpesvirus: clinical, pharmacological and basic aspects. (1982) (0)
Inhibition of Poly(adenosine Diphosphate-Ribose) Polymerase Thymidine Analogues in LI 210 Cells and Its Relationship to the Potentiation of the Antitumor Activity of l,3-Bis(2-chloroethyl)-l-nitrosourea but not of 3'-[3-(2-Chloroethyl)-3-nitrosoureido]-3'-deoxythymidine' (2006) (0)
Antineoplastic Activity of 3′-(Chloroethyl)nitrosourea Analogues of 2′-Deoxyuridine and 2′-Deoxy-5-fluorouridine. (1986) (0)
MOLECULAR BASIS FOR SERENDIPITOUS DEVELOPMENT OF ANTIVIRAL AND ANTICANCER AMINONUCLEOSIDES (1979) (0)
Biographical Sketch (2000) (0)
Effect of Thymidine on Uptake, DNA Alkylation, and DNA Repair in LI 210 Cells Treated with l,3-Bis(2-chloroethyl)-l-nitrosourea or 3'-[3-(2-Chloroethyl)-3- (2006) (0)
Inhibition and characterization of thymidylate (dtmp) kinase derived from mouse ascites sarcoma 180. Abstr. (1973) (0)
Short communicationDecrease of sensitivity to ultraviolet radiation of Streptococcus faecalis grown in media supplemented with 6-azathymine, an analog of thymine (1962) (0)
Synthesis and Antiviral Activity of Several 2,5′-Anhydro Analogues of 3′-Azido-3′-deoxythymidine, 3′-Azido-2′,3′-dideoxyuridine, 3′-Azido-2′,3′-dideoxy-5-halouridines, and 3′-Deoxythymidine Against Human Immunodeficiency Virus and Rau (1990) (0)
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-TRIFLUOROMETHYL-5′-AZIDO-2′,5′-DIDEOXYURIDINE AND 5-TRIFLUOROMETHYL-5′-AMINO-2′,5′-DIDEOXYURIDINE (1976) (0)
The effect of thymidine on the biological activity of 3'-ctnu and bcnu. Abstr. (1982) (0)
Synthesis and Biological Activity of 5-Phenylseleneny1-Substituted Pyrimidine Nucleosides. (1986) (0)

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