William p. Arend
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Philosophy
William p. Arend's Degrees
- Doctorate Medicine University of California, San Francisco
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(Suggest an Edit or Addition)William p. Arend's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. (2010) (2232)
- The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). (2010) (1997)
- The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. (2010) (1952)
- The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. (2010) (1862)
- Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor (1990) (1096)
- Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist (1990) (1067)
- Interleukin-1 receptor antagonist: role in biology. (1998) (1049)
- Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. (1990) (980)
- The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. (2010) (969)
- Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis (1995) (869)
- Interleukin-1 receptor antagonist. (1993) (816)
- IL‐1, IL‐18, and IL‐33 families of cytokines (2008) (808)
- The American College of Rheumatology 1990 criteria for the classification of Henoch-Schönlein purpura. (2010) (796)
- The balance between IL-1 and IL-1Ra in disease. (2002) (681)
- The American College of Rheumatology 1990 criteria for the classification of vasculitis. Introduction. (2010) (621)
- Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. (1991) (588)
- The American College of Rheumatology 1990 criteria for the classification of vasculitis. Summary. (2010) (569)
- Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. (1990) (564)
- Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. (2006) (548)
- Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. (1995) (330)
- Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. (1997) (327)
- Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor. (1985) (321)
- IL-1 family nomenclature (2010) (302)
- N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis (2011) (252)
- The American College of Rheumatology 1990 criteria for the classification of vasculitis. Patients and methods. (2010) (250)
- Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. (1994) (247)
- The American College of Rheumatology 1990 criteria for the classification of hypersensitivity vasculitis. (2010) (246)
- IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently. (1991) (217)
- Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. (1994) (216)
- The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils. (1994) (211)
- Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. (1994) (210)
- An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties. (1989) (204)
- Biological role of interleukin 1 receptor antagonist isoforms (2000) (188)
- Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation. (1971) (179)
- Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis (2012) (176)
- Physiology of cytokine pathways in rheumatoid arthritis. (2001) (167)
- Alternative Complement Pathway Activation Is Essential for Inflammation and Joint Destruction in the Passive Transfer Model of Collagen-Induced Arthritis1 (2006) (158)
- Interleukin-1 receptor antagonist production by human keratinocytes. (1992) (157)
- Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody. (2004) (147)
- Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein 1 (2003) (139)
- Cytokine imbalance in the pathogenesis of rheumatoid arthritis: the role of interleukin-1 receptor antagonist. (2001) (132)
- The macrophage receptor for IgG: number and affinity of binding sites. (1973) (131)
- Interleukin-1 receptor antagonist in normal and psoriatic epidermis. (1992) (126)
- Pathogenic Complement Activation in Collagen Antibody- Induced Arthritis in Mice Requires Amplification by the Alternative Pathway1 (2007) (123)
- Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice (2012) (115)
- Physiologic role of interleukin-1 receptor antagonist (2000) (114)
- Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (1993) (101)
- The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes. (1998) (98)
- Characterization of a low molecular weight isoform of IL-1 receptor antagonist. (1998) (97)
- Induction of tissue transglutaminase in human peripheral blood monocytes (1984) (95)
- FATE OF PREFORMED IMMUNE COMPLEXES IN RABBITS AND RHESUS MONKEYS (1971) (94)
- Studies on antigen-antibody complexes. II. Quantification of tissue uptake of soluble complexes in normal and complement-depleted rabbits. (1971) (93)
- Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways. (2003) (92)
- The innate immune system in rheumatoid arthritis. (2001) (89)
- IN VITRO ADHERENCE OF SOLUBLE IMMUNE COMPLEXES TO MACROPHAGES (1972) (88)
- Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. (2005) (88)
- The mode of action of cytokine inhibitors. (2002) (88)
- The pathophysiology and treatment of rheumatoid arthritis. (1997) (84)
- Mechanisms of effects of complement inhibition in murine collagen-induced arthritis. (2002) (84)
- Production of IL-1 receptor antagonist by human in vitro-derived macrophages. Effects of lipopolysaccharide and granulocyte-macrophage colony-stimulating factor. (1991) (80)
- Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies. (2008) (79)
- Interleukin-4 (IL-4) and IL-13 enhance the effect of IL-1beta on production of IL-1 receptor antagonist by human primary hepatocytes and hepatoma HepG2 cells: differential effect on C-reactive protein production. (1999) (76)
- IL-1 beta production in cultured human monocytes is regulated at multiple levels. (1989) (76)
- Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. (1997) (73)
- Clinical differentiation between giant cell (temporal) arteritis and Takayasu's arteritis. (1996) (73)
- Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody-Induced Arthritis in Mice1 (2009) (72)
- Production of IL‐1 receptor antagonist by hepatocytes is regulated as an acute‐phase protein in vivo (2001) (72)
- Interleukin-1 receptor antagonist: discovery, structure and properties. (1990) (68)
- The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region. (1993) (66)
- Tumor necrosis factor-α induces interleukin-1α and interleukin-1 receptor antagonist production by cultured human keratinocytes (1993) (65)
- Regulation of nuclear antigen expression on the cell surface of human monocytes. (1992) (65)
- LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements. (1994) (63)
- Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome. (1980) (60)
- Cytokines in the rheumatic diseases. (2004) (59)
- IgG Induction of IL‐1 Receptor Antagonist Production by Human Monocytes (1994) (58)
- Do hyperplastoid cell lines "differentiate themselves to death"? (1975) (58)
- Neutral protease secretion by human monocytes. Effect of surface-bound immune complexes (1979) (57)
- Expression of interleukin-1α, interleukin-1β, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells (1992) (55)
- Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis. (2001) (54)
- Generation and characterization of mice transgenic for human IL‐18‐binding protein isoform a (2003) (54)
- Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions. (1997) (53)
- Essential Role of Complement Mannose-Binding Lectin-Associated Serine Proteases-1/3 in the Murine Collagen Antibody-Induced Model of Inflammatory Arthritis (2010) (53)
- Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis (2006) (52)
- Peripheral blood neutrophil production of interleukin-1 receptor antagonist and interleukin-1β (2005) (51)
- Absence of induction of IL-1 production in human monocytes by complement fragments. (1989) (49)
- Autoimmune neutropenia in systemic lupus erythematosus. (1978) (49)
- Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome1 (2005) (48)
- Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF (1993) (48)
- Characterization of immune complexes and immunoglobulin G antibodies reactive with neutrophils in the sera of patients with Felty's syndrome. (1980) (47)
- Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase. (2004) (45)
- Characteristics of bacterial lipopolysaccharide induction of interleukin 1 synthesis and secretion by human monocytes. (1986) (45)
- Serum disappearance and catabolism of homologous immunoglobulin fragments in rats. (1975) (44)
- Complement activation pathways in murine immune complex‐induced arthritis and in C3a and C5a generation in vitro (2010) (44)
- Human IL-1 receptor antagonist promoter. Cell type-specific activity and identification of regulatory regions. (1992) (42)
- Molecular composition and sedimentation characteristics of soluble antigen-antibody complexes. (1972) (40)
- Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock (1999) (40)
- IL-1ra ELISA: reduction and alkylation of synovial fluid eliminates interference by IgM rheumatoid factors. (1991) (40)
- Neutrophil-binding immunoglobulin G in systemic lupus erythematosus. (1979) (38)
- Mice transgenic for intracellular interleukin‐1 receptor antagonist type 1 are protected from collagen‐induced arthritis (2003) (37)
- Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y1 (2003) (37)
- Treatment of rheumatoid arthritis with IL-1 inhibitors (2004) (37)
- Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic nucleotides (1980) (34)
- Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression (2014) (33)
- Determination of soluble immune complex molar composition and antibody association constants by ammonium sulfate precipitation. (1974) (32)
- The effect of complement depletion on wound healing. (1974) (32)
- Effect of immune complexes on human neutrophil phagocytic function. (1982) (31)
- Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis (2013) (28)
- Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice (2013) (27)
- Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms (1997) (27)
- Lipopolysaccharide and interleukin 1 inhibit interferon-gamma-induced Fc receptor expression on human monocytes. (1987) (26)
- The effects of differentiating agents on IL-1 beta production in cultured human monocytes. (1990) (26)
- Chronic neutropenia: possible association with Sjögren's syndrome. (1981) (26)
- Characteristics of chondrocyte responses to a human interleukin 1-like factor. (1985) (26)
- Nonsecretory myeloma. Immunofluorescent demonstration of paraprotein within bone marrow plasma cells (1974) (26)
- INTERLEUKINS AND ARTHRITIS IL-1 antagonism in inflammatory arthritis (1993) (25)
- Cytokines and cellular interactions in inflammatory synovitis. (2001) (25)
- Enhanced production of IL-1 receptor antagonist by alveolar macrophages from patients with interstitial lung disease. (1993) (24)
- The biological role of naturally-occurring cytokine inhibitors. (1991) (24)
- Differential binding of human interleukin‐1 (IL‐1) receptor antagonist to natural and recombinant soluble and cellular IL‐1 type I receptors (1995) (23)
- Inhibiting the effects of cytokines in human diseases. (1995) (23)
- Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. (2011) (22)
- Interaction of recombinant monocyte-derived interleukin 1 receptor antagonist with rheumatoid synovial cells. (1991) (19)
- Cytokine-induced differentiation of cultured nonadherent macrophages. (1992) (19)
- Regulation of interleukin 1 production in human monocytes. I. Effects of gamma-interferon and cycloheximide. (1988) (19)
- Characteristics of fibrinolytic enzyme release from human monocytes. (1981) (18)
- The effect of complement in adherent immune complexes on Fc and C3 receptor expression in human monocytes. (1981) (16)
- Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. (1992) (16)
- Mixed cryoglobulinemia associated with chronic Q-fever. (1991) (15)
- Tumor necrosis factor-alpha induces interleukin-1 alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes. (1993) (14)
- Monocyte-reactive antibodies in patients with systemic lupus erythematosus. (1977) (13)
- Interleukin-1 inhibitors (1987) (12)
- CHAPTER 28 – Interleukin-1 receptor antagonist [IL-1F3] (2003) (11)
- The human intracellular interleukin 1 receptor antagonist promoter appropriately regulates gene expression in keratinocytes and gastrointestinal epithelial cells in vivo. (1999) (11)
- The role of interleukin-1 receptor antagonist in the prevention and treatment of disease (2003) (11)
- IL-1 antagonism in inflammatory arthritis. (1993) (11)
- Fate of preformed immune complexes in rabbits and rhesus monkeys. (1971) (11)
- Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA. (2007) (11)
- A unified list of acronyms for the rheumatology literature. (1998) (10)
- Composition and biologic properties of soluble IgG-anti-IgG immune complexes: effects of variations in the specificity of rabbit antibodies to different structural components of human IgG. (1979) (9)
- Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1 alpha, IL-3, IL-4 and GM-CSF. (1993) (9)
- STUDIES ON ANTIGEN-ANTIBODY COMPLEXES (1971) (8)
- May 2001: 32 year old female with dural mass encircling cervical spinal cord (2001) (8)
- Grobmyer, S. R. et al. Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock: Paradoxical increase in products of caspase 1 (ICE). Mol. Med. 5, 585−594 (1999) (7)
- A uniform reference system for rheumatology journals. (1997) (6)
- The development of anticytokine therapeutics for rheumatic diseases. (2008) (5)
- Stimulation of Production of Interleukin-1 and an Interleukin-1 Inhibitor in Human Monocytes (1985) (5)
- The Influence of Personality Characteristics And Test Anxiety on Physician Assistant Clinical Knowledge Rating and Assessment Tool (PACKRAT) Performance (2006) (4)
- Arthritis & Rheumatism in 1997 (1997) (4)
- Characterization of two species of Fc fragments obtained from rat IgG2a by prolonged papain digestion. (1977) (4)
- Arthritis & Rheumatism in 2000. (2000) (4)
- Commentary Physiologic role of interleukin-1 receptor antagonist (2000) (3)
- Treatment with Cl-amidine, a peptidyl arginine deiminase (PAD) inhibitor, significantly reduces collagen-induced arthritis (CIA) (50.6) (2009) (3)
- 264 – Approach to the Patient with Rheumatic Disease (2012) (3)
- Training in Subspecialty Internal Medicine: On the Chessboard of Health Care Reform (1994) (3)
- Independent roles for complement C3a and C5a receptors and the membrane attack complex in the pathogenesis of collagen antibody-induced arthritis in mice: Potential therapeutic implications (2011) (2)
- Receptor-targeted immunotherapy. (1992) (2)
- Erratum: IL-1 family nomenclature (2011) (2)
- Mechanisms of gamma interferon and cycloheximide enhancement of interleukin 1 production in cultured human monocytes (1987) (2)
- Cytokine inhibition in the treatment of rheumatic and inflammatory diseases (1998) (2)
- Isoform of IL-1 Receptor Antagonist Characterization of a Low Molecular Weight (1998) (2)
- Signalosome in Keratinocytes through Binding to the 1 Inhibits IL-1-Induced Cytokine Production Intracellular IL-1 Receptor Antagonist Type (2005) (1)
- Potential roles for local adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice (2013) (1)
- Human Interleukin-1 Stimulation of Collagenase Production in Rabbit Articular Chondrocytes (1985) (1)
- Science on trial. Marcia Angell, MD. New York, W. W. Norton, 1996. 256 pp. Indexed. $27.50 (1996) (1)
- James carl steigerwald, 1935–1988 (1988) (1)
- Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis (2012) (1)
- Risk of Aspiration Pneumonia in the Elderly (2017) (1)
- Inhibitors of interleukin-1. (1989) (1)
- Clinical therapeutics. (1997) (0)
- Charley J. Smyth, MD, 1909‐1997 (1998) (0)
- Targeted inhibition of the alternative pathway of complement with complement receptor 2-factor H protein attenuates collagen antibody-induced arthritis in mice (2009) (0)
- Gene / Protein y Inhibitor Complement Receptor 1-Related Mice Transgenic for the Complement Prevention of Collagen-Induced Arthritis in (2003) (0)
- The alternative pathway of complement alone can mediate collagen antibody-induced arthritis in mice and generate high levels of C5a in vitro (2008) (0)
- Interleukin-1 inhibitors encoding DNA sequences, containing the vectors and host cells and a method for producing interleukin-1 inhibitors (1990) (0)
- Essential role of complement MASP-1/3 in the murine collagen antibody-induced model of inflammatory arthritis 1 (2010) (0)
- Transglutaminases are a group of enzymes that catalyze the covalent conju- gation of amines to protein-bound glutamine residues. The products of transglu- taminase activity are proteins covalently cross-linked by ~-(3"-glutaminyl)-lysine isopeptide bonds and proteins containing covalently conjugated (1984) (0)
- ArthritisAntibody-Induced Model of Inflammatory Proteases-1/3 in the Murine Collagen Mannose-Binding Lectin-Associated Serine Essential Role of Complement (2010) (0)
- Targeting interleukin-1 in rheumatic diseases (2007) (0)
- Antibody-Induced Arthritis in Mice Complement Protein C6 Deficiency in Collagen Role of C3a Receptors, C5a Receptors, and (2012) (0)
- Neutrophils and Monocytes of IL-1 Receptor Antagonist by Human The Differential Production of Three Forms (1998) (0)
- Interleukin-1 Receptor Antagonist Isoforms in Collagen-Induced Arthritis (1999) (0)
- The Alternative Pathway is Necessary and Sufficient for Complement Involvement in the Effector Phase of Anti-Collagen Antibody Induced Arthritis (ACAIA) (2007) (0)
- Contributors (2012) (0)
- Antibody-Induced Arthritis in Mice Receptor 2 and Factor H Attenuates Collagen Alternative Pathway with Complement Targeted Inhibition of the Complement (2009) (0)
- A Unified List of Acronyms for the Rheumatology Literature (1999) (0)
- 1122 THE AMERICAN COLLEGE OF RHEUMATOLOGY 1990 CRITERIA FOR THE CLASSIFICATION OF GIANT CELL ARTERITIS (2010) (0)
- Interleukin-1 and its receptor antagonist in inflammatory arthritis (2015) (0)
- Arthritis Murine Collagen Antibody-Induced Model of Lectin-Associated Serine Proteases-1 / 3 in the Essential Role of Complement Mannose-Binding (2010) (0)
- The relative roles of tumor necrosis factor alpha (TNF-A) and interleukin-1 (IL-1) in the induction of intercellular adhesion molecule-1 (ICAM-1) in human epidermis by ultraviolet radiation (1993) (0)
- MiceComplement in Inflammatory Arthritis in Activation of the Alternative Pathway of Roles of Adipocytes and Fibroblasts in (2013) (0)
- The lectin pathway of complement activation participates in the passive transfer model of collagen-induced arthritis (2007) (0)
- Collagen-Induced Arthritis Destruction in the Passive Transfer Model of Is Essential for Inflammation and Joint Alternative Complement Pathway Activation (2006) (0)
- Issue Information (1986) (0)
- Collagen-Induced Arthritis Inhibitor , Reduces the Severity of Murine hine Amide , a Protein Arginine Deiminase-Benzoyl-N 5-( 2-Chloro-1-Iminoethyl )-l-Ornit α (2011) (0)
- Results Transglutaminase in Freshly Isolated and Cultured Monocytes (2003) (0)
- Antibodies to citruiline-modified proteins enhance tissue injury in inflammatory arthritis. (2005) (0)
- O9The alternative pathway is both necessary and sufficient for the complement-dependent injury found in the effector phase of collagen antibody induced arthritis (CAIA) (2007) (0)
- IN VITRO A D H E R E N C E OF SOLUBLE I M M U N E CO MP LEX ES TO MACROPHAGES* BY WILLIAM P. AREND$ AND MART MANNIK (2003) (0)
- Binding Protein Collagen-Induced Arthritis by Murine IL-18 Mechanisms of Inhibition of (2013) (0)
- Collagen Antibody-Induced Arthritis in Mice Complement Protein C6 Deficiency in Role of C3a Receptors, C5a Receptors, and (2011) (0)
- I-4 : IL-1 and IL-1 Ra in rheumatoid arthritis (2002) (0)
- A recombinant DNA method for the production of a receptor antagonist of interleukin 1 (IL-li) (1989) (0)
- Arthritis Reduces the Severity of Murine Collagen-Induced Amide , a Protein Arginine Deiminase Inhibitor ,-Benzoyl-N 5-( 2-Chloro-1-Iminoethyl )-l-Ornithine (2011) (0)
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