William R. Shapiro
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Biophysics
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William R. Shapirophilosophy Degrees
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Physics Philosophy
William R. Shapiro's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Biophysics University of California, Berkeley
Why Is William R. Shapiro Influential?
(Suggest an Edit or Addition)William R. Shapiro's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. (1980) (1601)
- A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse (2000) (932)
- Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. (1975) (643)
- Cellular-telephone use and brain tumors. (2001) (503)
- Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. (2008) (472)
- Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. (1983) (419)
- Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. (1999) (353)
- Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas. (1981) (322)
- Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. (1989) (265)
- Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. (1996) (261)
- The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group. (1988) (259)
- A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma. (1992) (229)
- Studies on the chemotherapy of experimental brain tumors: development of an experimental model. (1970) (216)
- History of allergies and autoimmune diseases and risk of brain tumors in adults (2002) (210)
- Heterogeneous chemosensitivities of subpopulations of human glioma cells in culture. (1982) (182)
- Results of a randomized trial comparing BCNU plus radiotherapy, streptozotocin plus radiotherapy, BCNU plus hyperfractionated radiotherapy, and BCNU following misonidazole plus radiotherapy in the postoperative treatment of malignant glioma. (1989) (179)
- Reevaluating the imaging definition of tumor progression: perfusion MRI quantifies recurrent glioblastoma tumor fraction, pseudoprogression, and radiation necrosis to predict survival (2012) (172)
- Necrotizing Encephalopath Following Intraventricular Instillatio of Methotrexate (1973) (164)
- Treatment of meningeal neoplasms. (1977) (163)
- Spontaneous recurrent hypothermia accompanying agenesis of the corpus callosum. (1969) (161)
- Safety and Feasibility of Convection-enhanced Delivery of Cotara for the Treatment of Malignant Glioma: Initial Experience in 51 Patients (2005) (160)
- The Brain Tumor Cooperative Group NIH Trial 87-01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine. (2002) (159)
- Therapy of adult malignant brain tumors: what have the clinical trials taught us? (1986) (155)
- Meningeal gliomatosis: A review of 12 cases (1980) (150)
- The Brain Tumor Cooperative Group NIH Trial 87-01: A Randomized Comparison of Surgery, External Radiotherapy, and Carmustine versus Surgery, Interstitial Radiotherapy Boost, External Radiation Therapy, and Carmustine (2002) (147)
- Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points. (2002) (144)
- Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma (2009) (139)
- Treatment of neuroectodermal brain tumors (1982) (138)
- Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma. (2014) (136)
- Reproductive and hormonal factors and risk of brain tumors in adult females (2005) (133)
- Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial. (2009) (128)
- DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. (2010) (128)
- Experimental spinal cord compression by epidural neoplasms (1977) (127)
- Opening the blood–brain and blood–tumor barriers in experimental rat brain tumors: The effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow (1986) (124)
- Human brain tumor transplantation into nude mice. (1979) (122)
- Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration. (1977) (114)
- Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma (2012) (104)
- Oxidative response gene polymorphisms and risk of adult brain tumors. (2008) (101)
- Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine (2001) (101)
- Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults (2007) (100)
- Sociodemographic indicators and risk of brain tumours. (2003) (97)
- Treatment of malignant glioma. A controlled study of chemotherapy and irradiation. (1976) (93)
- Is gross-total resection sufficient treatment for posterior fossa ependymomas? (2002) (92)
- Treatment of experimental spinal cord compression caused by extradural neoplasms. (1977) (87)
- Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. (2003) (85)
- Lead, Genetic Susceptibility, and Risk of Adult Brain Tumors (2006) (80)
- Principles of brain tumor chemotherapy. (1986) (79)
- Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate. (1970) (79)
- Corticosteroid hormones. Effects in an experimental brain tumor. (1974) (75)
- A model of radiation myelopathy in the rat. Pathology, regional capillary permeability changes and treatment with dexamethasone. (1988) (74)
- Occupation and the risk of adult glioma in the United States (2003) (70)
- Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids. (1990) (68)
- Xenograft of Human Malignant Glial Tumors into Brains of Nude Mice A Histopathological Study (1981) (63)
- Treatment of malignant gliomas with interstitial irradiation and hyperthermia. (1992) (62)
- Necrotizing encephalopathy following intraventricular instillation of methotrexate. (1973) (62)
- Treatment modalities for leptomeningeal metastases. (2009) (61)
- Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a quantitative autoradiographic study. (1988) (56)
- Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: preliminary observations and pharmacokinetic implications. (1981) (56)
- A randomized phase III/IV study to determine benefit and safety of cytarabine liposome injection for treatment of neoplastic meningitis. (2006) (53)
- In vitro drug sensitivity testing in human gliomas. (1987) (52)
- The uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma. (1970) (49)
- Metastatic tumor of the brain: Development of an experimental model (1977) (48)
- Current therapy for brain tumors: back to the future. (1999) (47)
- Chemotherapy of experimental meningeal carcinomatosis. (1977) (47)
- Enhancement of CNS penetration of methotrexate by hyperosmolar intracarotid mannitol or carcinomatous meningitis (1979) (47)
- MENINGEAL CARCINOMATOSIS: DEVELOPMENT OF AN EXPERIMENTAL MODEL (1977) (47)
- Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: A pathological study (1989) (47)
- Treatment of cataplexy with clomipramine. (1975) (45)
- Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil. (1971) (44)
- Season of birth and risk of brain tumors in adults (2004) (44)
- Clonal Tumor Cell Heterogeneity1 (1984) (43)
- Occupational exposure to magnetic fields and the risk of brain tumors. (2009) (43)
- The subpopulations and isolated cell types of freshly resected high grade human gliomas: Their influence on the tumor's evolutionin vivo and behavior and therapyin vitro (2004) (43)
- 131I-chTNT-1/B mAb: tumour necrosis therapy for malignant astrocytic glioma (2006) (41)
- Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis. (1983) (39)
- Chemotherapy of primary malignant brain tumors in children (1975) (39)
- Self-reported electrical appliance use and risk of adult brain tumors. (2005) (36)
- Temporal effects of dexamethasone on blood-to-brain and blood-to-tumor transport of 14C-alpha-aminoisobutyric acid in rat C6 glioma (1990) (35)
- Leptomeningeal Metastases in High-Grade Adult Glioma: Development, Diagnosis, Management, and Outcomes in a Series of 34 Patients (2014) (34)
- Vasogenic brain edema induced by arachidonic acid: role of extracellular arachidonic acid in blood-brain barrier dysfunction. (1992) (34)
- Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. (2006) (34)
- Chromosome number and carmustine sensitivity in human gliomas (1993) (33)
- Cancer in first-degree relatives and risk of glioma in adults. (2003) (32)
- Intra-arterial Cisplatin Plus Oral Etoposide for the Treatment of Recurrent Malignant Glioma: A Phase II Study (2004) (32)
- Neurological complications of antineoplastic therapy. (1984) (32)
- Occupation and risk of meningioma and acoustic neuroma in the United States. (2004) (32)
- Experimental spinal cord compression by epidural neoplasm. (1977) (31)
- Heterogeneous response to chemotherapy of human gliomas grown in nude mice and as clones in vitro. (1981) (31)
- Chronic methotrexate toxicity to the central nervous system. (1980) (31)
- Genetic variation in insulin-like growth factors and brain tumor risk. (2008) (30)
- Chemotherapy of experimental metastatic brain tumors in female Wistar rats. (1979) (29)
- Study Design for a Case Control Investigation of Cellular Telephones and Other Risk Factors for Brain Tumors in Adults (1999) (29)
- δ-Aminolevulinic Acid Dehydratase Polymorphism and Risk of Brain Tumors in Adults (2005) (29)
- Does the CO2 laser spread viable brain-tumor cells outside the surgical field? (1984) (29)
- Biology and treatment of malignant glioma. (1998) (27)
- Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. (2006) (27)
- Decompression of epidural metastases from germ cell tumors with chemotherapy (1990) (25)
- Low-grade glioma: Supratentorial astrocytoma, oligodendroglioma, and oligoastrocytoma in adults (2004) (25)
- A phase II study of daily afatinib (BIBW 2992) with or without temozolomide (21/28 days) in the treatment of patients with recurrent glioblastoma. (2011) (24)
- Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a phase III trial. (2006) (24)
- Results of a randomized trial comparing intra-arterial cisplatin and intravenous PCNU for the treatment of primary brain tumors in adults: Brain Tumor Cooperative Group trial 8420A (2005) (23)
- The chemotherapy of intracerebral vs subcutaneous murine gliomas. A comparative study of the effect of VM 26. (1974) (23)
- Meningioma and schwannoma risk in adults in relation to family history of cancer. (2004) (22)
- Magnetic resonance imaging volumetric assessment of the extent of contrast enhancement and resection in oligodendroglial tumors. (2012) (22)
- Reevaluating the efficacy of intra-arterial BCNU. (1987) (22)
- Acute effects of low-dose cranial irradiation on regional capillary permeability in experimental brain tumors (1989) (21)
- Laterality of Brain Tumors (2003) (20)
- Low‐grade gliomas: When to treat? (1992) (19)
- Local blood-to-tissue transport in Walker 256 metastatic brain tumors (2004) (19)
- Handedness and risk of brain tumors in adults. (2003) (18)
- Interaction between route of intra-CSF chemotherapy administration and efficacy of therapy in patients wtih neoplastic meningitis. (2006) (17)
- Chemotherapy of malignant gliomas: studies of the BTCG. (1992) (17)
- Experimental meningeal carcinomatosis selectively depresses local cerebral glucose utilization in rat brain (1989) (16)
- Local blood flow in Walker 256 metastatic brain tumors (1984) (15)
- The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors. (1972) (15)
- Clonal tumor cell heterogeneity. (1984) (13)
- AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma (2014) (13)
- Identical non-random karyotypic changes seen in the primary cytogenetic analyses of low grade and high grade gliomas (1985) (12)
- Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors. (1979) (12)
- Prevention of Central Nervous System Leukaemia in Acute Lymphoblastic Leukaemia with Prophylactic Chemotherapy Alone (1979) (12)
- Cisternal and lumbar acid-base balance in patients with acute brain injuries: its association with respiratory alkalosis. (1968) (11)
- Cerebrospinal Fluid Circulation and the Blood‐Brain Barrier (1988) (11)
- Editorial: Brain tumor. Current status of treatment and its complications. (1975) (11)
- Polio vaccination and risk of brain tumors in adults: no apparent association. (2003) (11)
- Increased capillary permeability in rat brain induced by factors secreted by cultured C6 glioma cells: role in peritumoral brain edema (1991) (10)
- Chemotherapy of Metastatic Central Nervous System Carcinoma (1980) (9)
- Chemotherapy of Brain Tumors — Basic Concepts (1983) (8)
- BCNU-sensitivity in parental cells and clones from four freshly resected near-diploid human gliomas: An astrocytoma, an anaplastic astrocytoma and two glioblastomas multiforme (1993) (8)
- The effect of chemotherapeutic agents on an experimental mouse brain tumor. Abstr. (1968) (7)
- Bias in Uncontrolled Brain Tumor Trials (1997) (7)
- A randomized, double-blind study comparing corticorelin acetate with dexamethasone in patients with primary malignant glioma who require increased dexamethasone doses to control symptoms of peritumoral brain edema. (2009) (7)
- Chemotherapy of malignant glioma with CCNU alone and CCNU combined with vincristine sulfate and procarbazine hydrochloride. (1976) (7)
- Combined modality treatment of malignant glioma. (1985) (6)
- Apparent glucose utilization in Walker 256 metastatic brain tumors (2005) (6)
- Human malignant gliomas secrete a factor that increases brain capillary permeability: role in peritumoural brain oedema. (1990) (6)
- Biopsy vs. extensive resection for first recurrence of glioblastoma: is a prospective clinical trial warranted? (2015) (6)
- Animal models: blood-brain barrier and pharmacology. (1985) (6)
- Selected human leukocyte antigen class II polymorphisms and risk of adult glioma (2011) (5)
- Stereotactic Cerebral Irradiation (INSERM Symposium No. 12) (1981) (5)
- Prognostic factors for patients with newly diagnosed low-grade oligodendroglial tumors: molecular genetics, histopathology, and neuroimaging (2005) (5)
- Effect of chemotherapeutic agents on experimental brain tumors. Abstr. (1969) (5)
- Treatment of Cataplexy with Clomipramine. (1975) (5)
- Possible mechanism of vasogenic brain oedema induced by arachidonic acid. (1990) (4)
- Correlation of BCNU resistance in human glioma cells with over-representation of chromosome 22 and production of a factor resembling platelet-derived growth factor (PDGF) (1985) (4)
- Chemotherapy of primary malignant brain tumors in children. (1975) (4)
- High-dose methotrexate in malignant gliomas. (1977) (4)
- A changing paradigm of glioma biology. (2006) (4)
- Remote effects of Neoplasm on the central nervous system: encephalopathy. (1976) (4)
- Motexafin gadolinium prolongs time to neurologic progression in lung cancer patients with brain metastases: results of a randomized phase III trial (2002) (3)
- Motexafin gadolinium (MGd) combined with whole brain radiation therapy prolongs time to neurologic progression in non- small cell lung cancer (NSCLC) patients with brain metastases: Pooled analysis of two randomized phase III trials (2007) (3)
- Effects of low dose BCNU chemotherapy on human glioma cell lines in vitro (1981) (3)
- Vasogenic Brain Edema Induced by Arachidonic Acid (1992) (3)
- Superiority of PCNU over AZQ in the treatment of primary brain tumors: results of a prospective randomized trial (81-20) by the brain tumor study group (2005) (3)
- Life-threatening neurologicalcomplications of cancer (1979) (2)
- Treatment of experimental spinal compression caused by extradural neoplasms cord (1977) (2)
- MEDICAL RADIATION THERAPIES (2013) (2)
- Current approaches to chemotherapy (1986) (2)
- Glial fibrillary acidic protein (GFA) and vimentin in human glioma cells (1981) (2)
- Heterogeneous chemosensitivities of human glioma cell lines by colony forming assay (CFA) (1981) (2)
- Brain tumors. (1988) (2)
- Langerhans Cell Histiocytosis in an Adult with Involvement of the Calvarium, Cerebral Cortex and Brainstem: Discussion of Pathophysiology and Rationale for the Use of Intravenous Immune Globulin (2015) (2)
- Central nervous system tumors. (2006) (2)
- Meningeal gliomatosis: a review of twelve cases. (1979) (2)
- Brain tumors. (1999) (1)
- Intracranial tumors--panel 2. (1979) (1)
- Experimental models of metastases to the nervous system. (1976) (1)
- Effect of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in sesame oil administered intramuscularly in the treatment of experimental brain tumors. (1972) (1)
- Open-label, dose confirmation study of interstitial 131I-chTNT-1/b mab for the treatment of glioblastoma multiforme (GBM) at first relapse: Interim results. (2011) (1)
- Recent Clinical Results in the Chemotherapy of Brain Tumors: BTCG Studies (1991) (1)
- Apparent glucose utilization in Walker 256 metastatic brain tumors (2005) (1)
- Cellular Telephones and Brain Tumors (2001) (1)
- A Model for Brain Metastasis (1980) (1)
- Lead, Genetic Susceptibility and Risk of Adult Brain Tumors (2006) (1)
- OMICS AND PROGNSTIC MARKERS (2013) (1)
- Open-label, dose confirmation, and dosimetry study of interstitial 131I-chTNT-1/B MAb for the treatment of recurrent glioblastoma multiforme (GBM): Final results. (2008) (1)
- Brain tumor chemotherapy. (1994) (1)
- Life-threatening neurological complications of cancer. (1979) (1)
- Current Therapy for Brain Tumors (2015) (1)
- Stereotactic radiosurgery for brain metastases from gastrointestinal tract cancer: Commentary (2003) (1)
- Intracranial ependymomas in the adult patient: the barrow neurological institute experience (2003) (1)
- Validation of blinded events review committee (ERC)-determined time to neurologic progression (TTNP) demonstrates correlation with survival, radiologic progression, and functional independence endpoints (2005) (1)
- Brain tumors. (2020) (0)
- Cisternography and Hydrocephalus: A Symposium. (1973) (0)
- Management of Primary Brain Tumors—1996 (1997) (0)
- The action of corticosteroid hormones in an experimental brain tumour model. (1973) (0)
- A comparative study of intracerebral vs subcutaneous implantation of murine glioma, differential sensitivity to vm26. Abstr. (1972) (0)
- Human gliomas - In vitro chemosensitivity testing by growth assay (1982) (0)
- Commentary (Green/Shapiro): Malignant Gliomas in Older Adults With Poor Prognostic Signs (1995) (0)
- Dosimetry of phase I interstitial 131I-chTNT-1/B MAb (Cotara) for the treatment of recurrent glioma (2009) (0)
- The Uptake , Distribution , and Antitumor Activity of 1-( 2-Chloroethyl } 3 cyc 1 oh @ exy 1 †” 1-nitrosourea in the Murine Glioma (2006) (0)
- BM-11LEPTOMENINGEAL METASTASES IN HIGH-GRADE ADULT GLIOMA: DEVELOPMENT, DIAGNOSIS, MANAGEMENT AND OUTCOMES IN A SERIES OF 34 PATIENTS (2014) (0)
- Abstract 4138: Five prognostic subgroups differ in expression of Akt pathway genes: Biomarkers for therapy selection (2011) (0)
- Brain tumors (2004) (0)
- Brain tumors. (2002) (0)
- Heterogeneity of human gliomas: II. Growth rate and chemosensitivity of cloned glioma cell lines in culture (1980) (0)
- Why, how, and when? Why did this happen? How should it be treated? When will there be a cure? (1995) (0)
- Leptomeningeal metastases in high-grade glioma: A series of 41 cases. (2014) (0)
- Hyperthermia of high-grade gliomas with ferromagnetic implants (1991) (0)
- CANCER NEUROLOGY IN CLINICAL PRACTICE. 2003. Edited by David Schiff and Patrick Y. Wen. Published by Human Press, Totowa NJ. 464 pages. (2003) (0)
- BERRY ANEURYSM IK AN INFANT: CASE REPORT (1993) (0)
- Comparison of 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine and cytosine arabinoside in the treatment of murine brain tumor. (1976) (0)
- Further studies on chemotherapy of experimental brain tumors. (1970) (0)
- [Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action]. (1989) (0)
- Reply (1987) (0)
- Brain tumors. (2003) (0)
- Glioblastoma Multiforme-Reply (1977) (0)
- Proceedings of the Workshop on Antimetabolites and the Central Nervous System (New York, NY, February 2-3, 1976): Introduction: antimetabolites and central nervous system neoplasia. (1977) (0)
- Brain tumors. (1997) (0)
- Brain tumors. (2001) (0)
- Book ReviewSleep Disorders: Basic and clinical research (1983) (0)
- Meningeal carcinomatosis. (1991) (0)
- Renal Failure in Paraplegia. (1970) (0)
- Abstract 3688: Akt pathway genes classify GBM into 6 prognostic subgroups with different clinical and molecular features (2012) (0)
- Brain tumors. (1993) (0)
- Brain tumors. (1991) (0)
- Commentary (Shapiro): Management of Brain Metastases (1999) (0)
- Neurological and neurosurgical approaches in the management of malignant brain tumours (1987) (0)
- Reply (1988) (0)
- MENINGEAL CARCINOMATOSIS: AN EXPERIMENTAL MODEL (1976) (0)
- Brain tumors. (1987) (0)
- Brain tumors. (1996) (0)
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What Schools Are Affiliated With William R. Shapiro?
William R. Shapiro is affiliated with the following schools:
