W. Wallace Cleland
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American biochemist
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W. Wallace Cleland's Degrees
- Bachelors Chemistry University of California, Berkeley
Why Is W. Wallace Cleland Influential?
(Suggest an Edit or Addition)According to Wikipedia, William Wallace Cleland Life and education Cleland was born in 1930 in Baltimore, Maryland. He received his A.B. from Oberlin College in 1950 and his M.S. and Ph.D. from the University of Wisconsin–Madison in 1953 and 1955, respectively. He was an avid stamp collector and was awarded the Lifetime Achievement Award in Philately by the Smithsonian Institution in 2008. Cleland died on March 6, 2013, after falling on ice.
W. Wallace Cleland's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS. (1964) (1782)
- The statistical analysis of enzyme kinetic data. (1967) (1270)
- Statistical analysis of enzyme kinetic data. (2006) (1155)
- The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. (1963) (1085)
- Low-barrier hydrogen bonds and enzymic catalysis. (1994) (787)
- The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory. (1963) (643)
- Computer Programmes for Processing Enzyme Kinetic Data (1963) (490)
- The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. 1963. (1989) (486)
- 1 Steady State Kinetics (1970) (442)
- The Low Barrier Hydrogen Bond in Enzymatic Catalysis* (1998) (417)
- The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection. (1963) (403)
- A specific and sensitive assay for disulfides. (1968) (380)
- Structure, mechanism and regulation of pyruvate carboxylase. (2008) (359)
- Enzyme kinetics revisited: a commentary on 'The Kinetics of Enzyme-Catalyzed Reactions With Two or More Substrates or Products'. (1989) (348)
- Enzymatic mechanisms of phosphate and sulfate transfer. (2006) (329)
- Mechanism of Rubisco: The Carbamate as General Base. (1998) (299)
- Partition analysis and the concept of net rate constants as tools in enzyme kinetics. (1975) (285)
- Symbiotic Nitrogen Fixation in the Fungus Gardens of Leaf-Cutter Ants (2009) (282)
- Enzyme Kinetics and Mechanism (2007) (271)
- Determining the chemical mechanisms of enzyme-catalyzed reactions by kinetic studies. (2006) (268)
- Stability constants of Mg2+ and Cd2+ complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of MgATP and MgADP. (1984) (254)
- Understanding enzymic catalysis: the importance of short, strong hydrogen bonds. (1997) (221)
- PRODUCT INHIBITION STUDIES ON YEAST AND LIVER ALCOHOL DEHYDROGENASES. (1963) (188)
- Low-barrier hydrogen bonds and low fractionation factor bases in enzymatic reactions. (1992) (185)
- KINETIC STUDIES OF GLUTAMIC OXALOACETIC TRANSAMINASE ISOZYMES. (1964) (159)
- Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase. (1982) (156)
- Low-barrier hydrogen bonds and enzymatic catalysis. (2000) (155)
- Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine ammonia-lyase. (1985) (141)
- Use of isotope effects to elucidate enzyme mechanisms. (1982) (138)
- Mechanistic deductions from isotope effects in multireactant enzyme mechanisms. (1981) (127)
- The enzymatic synthesis of psychosine. (1960) (127)
- Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme (2007) (126)
- 1-Acylglycerol 3-phosphate acyltransferase from rat liver. (1969) (123)
- The use of pH studies to determine chemical mechanisms of enzyme-catalyzed reactions. (1982) (118)
- What limits the rate of an enzyme-catalyzed reaction (1975) (118)
- The use of isotope effects to determine enzyme mechanisms. (2003) (118)
- Isotope exchange studies of the mechanism of the reaction catalyzed by adenosine triphosphate: creatine phosphotransferase. (1966) (117)
- Phosphorus-31 NMR studies of complexes of adenosine triphosphate, adenosine diphosphate, tripolyphosphate, and pyrophosphate with cobalt(III) ammines (1977) (117)
- Preparation and properties of chromium (3)-nucleotide complexes for use in the study of enzyme mechanisms. (1973) (117)
- Kinetic studies of yeast nucleoside diphosphate kinase. (1969) (114)
- pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same. (1981) (109)
- [7] Isocitrate dehydrogenase (TPN-specific) from pig heart (1969) (105)
- Kinetic and chemical mechanisms of yeast formate dehydrogenase. (1980) (105)
- The Use of Isotope Effects to Determine Enzyme Mechanisms (2003) (104)
- Use of chromium-adenosine triphosphate and lyxose to elucidate the kinetic mechanism and coordination state of the nucleotide substrate for yeast hexokinase. (1975) (103)
- [20] Substrate inhibition (1979) (102)
- Some physical properties of palmityl-coenzyme A micelles. (1968) (101)
- Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase. (1984) (100)
- Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions. (1980) (100)
- Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis. (1979) (98)
- Investigations of substrate specificity and reaction mechanism of several kinases using chromium(III) adenosine 5'-triphosphate and chromium(III) adenosine 5'-diphosphate. (1980) (97)
- Substrate activity of (adenosine triphosphato)tetraamminecobalt(III) with yeast hexokinase and separation of diastereomers using the enzyme. (1978) (95)
- Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase. (1981) (91)
- Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase. (1981) (88)
- Mechanisms of phosphoryl and acyl transfer (1995) (87)
- Preparation and properties of chromium(III) adenosine 5'-triphosphate, chromium(III) adenosine 5'-diphosphate, and related chromium(III) complexes. (1980) (85)
- Kinetic mechanism of glutamate dehydrogenase. (1980) (84)
- pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase. (1981) (82)
- Measurement of isotope effects by the equilibrium perturbation technique. (1980) (80)
- Kinetic studies of Escherichia coli galactokinase. (1968) (77)
- Pigeon liver malic enzyme. V. Kinetic studies. (1967) (76)
- Reaction intermediate analogues for enolase. (1984) (76)
- Inhibition of isocitrate lyase by 3-nitropropionate, a reaction-intermediate analogue. (1982) (75)
- Transition-state structures for enzymatic and alkaline phosphotriester hydrolysis. (1991) (75)
- Equilibrium perturbation by isotope substitution. (1975) (73)
- The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange studies. (1974) (72)
- Interaction of metal(III)-adenosine 5'-triphosphate complexes with yeast hexokinase. (1980) (72)
- Tracer experiments on the mechanism of citric acid formation by Aspergillus niger. (1954) (72)
- Inhibition of creatine kinase by chromium nucleotides. (1973) (71)
- Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase (1999) (70)
- Slow-binding inhibition: the general case. (1996) (69)
- Use of isotope effects to deduce the chemical mechanism of fumarase. (1980) (69)
- Studies on the microsomal acylation of L-glycerol-3-phosphate. II. The specificity and properties of the rat liver enzyme. (1969) (69)
- Insights into the mechanism of flavoprotein-catalyzed amine oxidation from nitrogen isotope effects on the reaction of N-methyltryptophan oxidase. (2007) (69)
- Purification and kinetic studies of beef liver cytoplasmic aconitase. (1967) (69)
- Bovine liver fructokinase: purification and kinetic properties. (1977) (68)
- Rat liver pyruvate carboxylase. II. Kinetic studies of the forward reaction. (1971) (68)
- Nitrogen isotope effects as probes of the mechanism of D-amino acid oxidase [17] (2000) (67)
- Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis. (2003) (65)
- Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin. (1998) (64)
- Kinetic Studies with Liver Alcohol Dehydrogenase (1965) (62)
- The use of isotope effects in the detailed analysis of catalytic mechanisms of enzymes (1987) (62)
- Mechanism of Rubisco: The Carbamate as General Base (1998) (62)
- Substrate synergism and the kinetic mechanism of yeast hexokinase. (1982) (62)
- Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies. (1977) (61)
- Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase. (1984) (60)
- AN ALLOSTERIC REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE OXIDASE FROM MYCOBACTERIUM TUBERCULOSIS. (1965) (59)
- Purification and kinetic studies of the citrate cleavage enzyme. (1967) (59)
- Substrate inhibition. (1979) (58)
- Nitro analogues of citrate and isocitrate as transition-state analogues for aconitase. (1980) (57)
- Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase. (1987) (57)
- Determination of the chemical mechanism of glutamate dehydrogenase from pH studies. (1980) (57)
- Inhibition and alternate-substrate studies on the mechanism of malic enzyme. (1977) (57)
- Purification and mechanism of action of hog liver mevalonic kinase. (1970) (57)
- Influence of salt, substrate, and cofactor concentrations on the kinetic and mechanistic behavior of phosphoglycerate mutase. (1968) (56)
- THE PARTIAL PURIFICATION, PROPERTIES, AND MECHANISM OF ACTION OF PIG LIVER ISOPENTENYL PYROPHOSPHATE ISOMERASE. (1965) (56)
- Studies on the formation of oxalic acid by Aspergillus niger. (1956) (55)
- The inhibition of acetate, pyruvate, and 3-phosphogylcerate kinases by chromium adenosine triphosphate. (1974) (55)
- The kinetic mechanism of glycerokinase. (1974) (55)
- The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. II. Dead-end and multiple inhibition studies. (1974) (55)
- Derivation of rate equations for multisite ping-pong mechanisms with ping-pong reactions at one or more sites. (1973) (54)
- Kinetic mechanism of Bacillus subtilis L-alanine dehydrogenase. (1981) (54)
- Rabbit muscle phosphofructokinase. II. Product and dead end inhibition. (1974) (53)
- Meanings of Ki for conventional and alternate-substrate inhibitors. (1981) (53)
- 3 Steady-State Kinetics (1990) (53)
- Isotope effects: determination of enzyme transition state structure. (1995) (52)
- Investigating the roles of putative active site residues in the oxalate decarboxylase from Bacillus subtilis. (2007) (51)
- Optimizing coupled enzyme assays. (1979) (50)
- Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate. (1984) (49)
- Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase. (2001) (49)
- pH variation of the kinetic parameters and the catalytic mechanism of malic enzyme. (1977) (48)
- Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues. (1988) (48)
- Mechanism of action of the nonspecific phosphomonoesterase from potatoes. (1966) (48)
- Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin. (2001) (47)
- Mechanistic studies of the flavoenzyme tryptophan 2-monooxygenase: deuterium and 15N kinetic isotope effects on alanine oxidation by an L-amino acid oxidase. (2006) (47)
- Low‐Barrier Hydrogen Bonds and Enzymic Catalysis. (1994) (47)
- High Resolution X-ray Structure of dTDP-Glucose 4,6-Dehydratase from Streptomyces venezuelae* (2004) (47)
- Studies of Transition-State Structures in PhosphorylTransfer Reactions of Phosphodiesters of p-Nitrophenol (1995) (46)
- Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 1. Liver alcohol dehydrogenase with benzyl alcohol and yeast aldehyde dehydrogenase with benzaldehyde. (1984) (46)
- Carbon-13 and deuterium isotope effects on oxalacetate decarboxylation by pyruvate carboxylase. (1986) (45)
- Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects. (2000) (44)
- X-ray crystal and molecular structure and absolute configuration of (dihydrogen tripolyphosphato) tetraamminecobalt(III) monohydrate, Co(NH3)4H2P3O10.H2O. A model for a metal-nucleoside polyphosphate complex. (1978) (44)
- Use of pH studies to elucidate the chemical mechanism of yeast hexokinase. (1978) (44)
- DIrect measurement of transition-state bond cleavage in hydrolysis of phosphate esters of p-nitrophenol (1990) (43)
- 13 C, 15 N, and 18 O equilibrium isotope effects and fractionation factors (1999) (43)
- Rabbit muscle phosphofructokinase. I. Anomeric specificity; initial velocity kinetics. (1974) (43)
- Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases. (1988) (42)
- Role of metal ions in catalysis by enolase: an ordered kinetic mechanism for a single substrate enzyme. (2001) (42)
- Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli. (2011) (42)
- Studies of the microsomal acylation of L-glycerol-3-phosphate. I. The specificity of the rat brain enzyme. (1969) (41)
- Studies on the microsomal acylation of L-glycerol-3-phosphate. 3. Time course of the reaction. (1969) (41)
- Determination of the chemical mechanism of malic enzyme by isotope effects. (1997) (41)
- Lanthanide-adenosine 5'-triphosphate complexes: determination of their dissociation constants and mechanism of action as inhibitors of yeast hexokinase (1983) (40)
- Enzyme Mechanisms from Isotope Effects (2005) (40)
- Determination of equilibrium 18O isotope effects on the deprotonation of phosphate and phosphate esters and the anomeric effect on deprotonation of glucose 6-phosphate (1986) (39)
- A kinetic investigation of phosphoenolpyruvate carboxylase from Zea mays. (1992) (39)
- Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli. (2009) (39)
- The substrate and anomeric specificity of fructokinase. (1973) (39)
- Isotope Effects on Enzyme-Catalyzed AcylTransfer from p-Nitrophenyl Acetate: Concerted Mechanisms and Increased Hyperconjugation inthe Transition State (1998) (38)
- The use of isotope effects to determine transition-state structure for enzymic reactions. (1982) (38)
- Characterization of the Transition-State Structures and Mechanisms for the Isomerization and Cleavage Reactions of Uridine 3‘-m-Nitrobenzyl Phosphate (2000) (38)
- Hydrolysis of phosphotriesters: determination of transition states in parallel reactions by heavy-atom isotope effects. (2001) (38)
- Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase. (1988) (37)
- HYDROGEN BONDING IN COMPLEXES OF CARBOXYLIC ACIDS WITH 1-ALKYLIMIDAZOLES :STERIC AND ISOTOPIC EFFECTS ON LOW BARRIER HYDROGEN BONDING (1999) (36)
- Are There Strong Hydrogen Bonds in Aqueous Solutions (1998) (35)
- pH profiles and isotope effects for aconitases from Saccharomycopsis lipolytica, beef heart, and beef liver. alpha-Methyl-cis-aconitate and threo-Ds-alpha-methylisocitrate as substrates. (1984) (35)
- Energetics of substrate binding, catalysis, and product release. (1999) (35)
- Kinetic analysis of the individual reductive steps catalyzed by beta-hydroxy-beta-methylglutaryl-coenzyme A reductase obtained from yeast. (1976) (35)
- The low-barrier hydrogen bond in enzymic catalysis (2010) (35)
- Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase. (1981) (35)
- 18O Isotope Effects Support a Concerted Mechanism for Ribonuclease A (1997) (34)
- Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction. (1991) (34)
- Evidence from multiple isotope effect determinations for coupled hydrogen motion and tunneling in the reaction catalyzed by glucose-6-phosphonate dehydrogenase (1984) (34)
- Carbon-13 and deuterium isotope effects on the catalytic reactions of biotin carboxylase. (1988) (34)
- Kinetic and isotope-exchange studies on shikimate dehydrogenase from Pisum sativum. (1971) (34)
- Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA. (2007) (33)
- Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA. (2012) (33)
- Enzymatic Mechanisms of Phosphate and Sulfate Transfer (2006) (33)
- Carbon isotope effect study on orotidine 5'-monophosphate decarboxylase: support for an anionic intermediate. (2008) (32)
- Decarboxylation of oxalacetate by pyruvate carboxylase. (1986) (32)
- The specificity of chromium nucleotides as inhibitors of selected kinases. (1974) (32)
- Phosphoryl Transfer Reactions of Phosphodiesters:Characterization of Transition States by Heavy Atom Isotope Effects (1991) (31)
- Secondary 18O isotope effects for hexokinase-catalyzed phosphoryl transfer from ATP. (1991) (31)
- Catalytic mechanism of biotin carboxylase: steady-state kinetic investigations. (1988) (31)
- Rat liver pyruvate carboxylase. 3. Isotopic exchange studies of the first partial reaction. (1971) (30)
- Stereospecificity of the metal--adenosine 5'-triphosphate complex in reactions of muscle pyruvate kinase. (1979) (30)
- Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli. (2011) (30)
- RING OPENING AND CLOSING RATES FOR THIOSUGARS (1979) (29)
- Kinetic competence of enzymic intermediates: fact or fiction? (1990) (29)
- Isotope exchange studies on liver alcohol dehydrogenase with cyclohexanol and cyclohexanone as reactants. (1972) (29)
- Isotope effects on the enzymatic and nonenzymatic reactions of chorismate. (2005) (29)
- Acid Catalyzed Condensations. I. 1,3,5-Triarylbenzenes1 (1953) (29)
- Use of intermediate partitioning to calculate intrinsic isotope effects for the reaction catalyzed by malic enzyme. (1985) (29)
- Preparation of chromium(III) and cobalt(III) nucleotides as chirality probes and inhibitors. (1982) (29)
- Reverse protonation is the key to general acid-base catalysis in enolase. (2003) (29)
- A kinetic method for determining dissociation constants for metal complexes of adenosine 5'-triphosphate and adenosine 5'-diphosphate. (1980) (28)
- Symmetry and asymmetry in mandelate racemase catalysis. (1985) (28)
- Kinetic and Structural Analysis of α-d-Glucose-1-phosphate Cytidylyltransferase from Salmonella typhi* (2005) (28)
- Alkaline phosphatase catalyzes the hydrolysis of glucose-6-phosphate via a dissociative mechanism (1989) (28)
- 15N kinetic isotope effects on uncatalyzed and enzymatic deamination of cytidine. (2002) (28)
- [20] An analysis of haldane relationships (1982) (28)
- Fatty acid synthetase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from pigeon liver. (1975) (27)
- Metal-catalyzed phosphodiester cleavage: secondary 18O isotope effects as an indicator of mechanism. (2006) (27)
- Activation and inhibition of pyruvate carboxylase from Rhizobium etli. (2011) (26)
- Kinetic Isotope Effects for Acyl Transfer from p-Nitrophenyl Acetate to Hydroxylamine Show a pH-Dependent Change in Mechanism (1997) (25)
- 13C and deuterium isotope effects suggest an aldol cleavage mechanism for L-ribulose-5-phosphate 4-epimerase. (2000) (25)
- pH properties and chemical mechanism of action of 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1981) (25)
- Secondary 18 O isotope effects as a tool for studying reactions of phosphate mono‐, di‐, and triesters1 (1990) (25)
- A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase. (2012) (24)
- [19] Initial velocity analysis for terreactant mechanisms (1982) (24)
- The catalytic base of enolase is a sulfhydryl group (1987) (23)
- Isotope effect studies of chicken liver NADP malic enzyme: role of the metal ion and viscosity dependence. (1988) (23)
- pH dependency of the reactions catalyzed by chorismate mutase-prephenate dehydrogenase from Escherichia coli. (1991) (23)
- Role of metal ions in the reaction catalyzed by L-ribulose-5-phosphate 4-epimerase. (2000) (22)
- Bimodal substrate inhibition of lactate dehydrogenase. Factors affecting the enzyme in vivo. (1978) (22)
- Kinetic studies on chorismate mutase-prephenate dehydrogenase from Escherichia coli: models for the feedback inhibition of prephenate dehydrogenase by L-tyrosine. (1991) (21)
- Kinetics of aminoacyl-tRNA synthetases catalyzed ATP-PPi exchange. (1974) (21)
- Secondary 18O and primary 13C isotope effects as a probe of transition-state structure for enzymatic decarboxylation of oxalacetate. (1994) (21)
- Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-ornithine. (2005) (21)
- pH studies on the chemical mechanism of rabbit muscle pyruvate kinase. 2. Physiological substrates and phosphoenol-alpha-ketobutyrate. (1985) (21)
- A novel method for determining rate constants for dehydration of aldehyde hydrates. (1984) (21)
- APPENDIX INHIBITION PATTERNS OBTAINED WHERE AN INHIBITOR IS PRESENT IN CONSTANT PROPORTION TO VARIABLE SUBSTRATE (1973) (20)
- Substrate specificity and kinetic mechanism of Escherichia coli ribulokinase. (2001) (20)
- Characterization of the transition-state structure of the reaction of kanamycin nucleotidyltransferase by heavy-atom kinetic isotope effects. (2001) (20)
- Mechanistic studies of phosphoenolpyruvate carboxylase from Zea mays with (Z)- and (E)-3-fluorophosphoenolpyruvate as substrates. (1992) (20)
- Studies on the tyrosine aminotransferase mechanism. (1968) (19)
- Secondary 18O isotope effects on the hydrolysis of glucose 6-phosphate (1986) (19)
- Metal ion catalyzed hydrolysis of ethyl p-nitrophenyl phosphate. (2003) (19)
- 13C isotope effects as a probe of the kinetic mechanism and allosteric properties of Escherichia coli aspartate transcarbamylase. (1992) (19)
- Mechanisms of Enzymatic Oxidative Decarboxylation (1999) (19)
- Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants. (1998) (19)
- Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses. (2012) (19)
- Isotope effects on enzyme-catalyzed reactions : [proceedings of the Sixth Annual Harry Steenbock Symposium, held in Madison, Wisconsin, on June 4 and 5, 1976] (1977) (18)
- Determination of the rate-limiting steps and chemical mechanism of fructokinase by isotope exchange, isotope partitioning, and pH studies. (1977) (18)
- Chorismate mutase-prephenate dehydrogenase from Escherichia coli. 1. Kinetic characterization of the dehydrogenase reaction by use of alternative substrates. (1990) (18)
- Probing the catalytic roles of Arg548 and Gln552 in the carboxyl transferase domain of the Rhizobium etli pyruvate carboxylase by site-directed mutagenesis. (2010) (18)
- Phosphorylated aminosugars: synthesis, properties, and reactivity in enzymatic reactions. (1991) (18)
- Secondary 15N isotope effects on the reactions catalyzed by alcohol and formate dehydrogenases. (1991) (18)
- pH studies on the chemical mechanism of rabbit muscle pyruvate kinase. 1. Alternate substrates oxalacetate, glycolate, hydroxylamine, and fluoride. (1985) (17)
- 13C and (15)N kinetic isotope effects on the reaction of aspartate aminotransferase and the tyrosine-225 to phenylalanine mutant. (2000) (17)
- Synthesis of various chelating celluloses and their application in removing Al3 from ATP. (1982) (16)
- MECHANISM OF PHOSPHODIESTER CLEAVAGE WITH BETA -CYCLODEXTRIN (1991) (16)
- Thiol and amino analogues as alternate substrates for glycerokinase from Candida mycoderma. (1989) (16)
- Steady-state kinetics and isotope effects on the mutant catalytic trimer of aspartate transcarbamoylase containing the replacement of histidine 134 by alanine. (1992) (16)
- Relationship of the oxidation state of the iron-sulfur cluster of aconitase to activity and substrate binding. (1981) (16)
- 15N isotope effects in glutamine hydrolysis catalyzed by carbamyl phosphate synthetase: evidence for a tetrahedral intermediate in the mechanism. (2000) (16)
- Carbon-13 and deuterium isotope effects on the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase. (1991) (16)
- Enthalpic Studies of Complex Formation between Carboxylic Acids and 1-Alkylimidazoles (1998) (16)
- An analysis of Haldane Relationships. (1982) (15)
- Heavy-Atom Isotope Effects on Reactions ofCo(III)-Bound p-Nitrophenyl Phosphate: Nucleophilic Displacements of p-Nitrophenol andDissociation of p-Nitrophenyl Phosphate (1997) (15)
- Carbon isotope effects on the metal ion catalyzed decarboxylation of oxalacetate (1986) (15)
- pH‐rate profiles support a general base mechanism for galactokinase (Lactococcus lactis) (2013) (15)
- Nitrogen-15 isotope effects on nonenzymic and aspartate transcarbamylase catalyzed reactions of carbamyl phosphate (1992) (15)
- Multiple isotope effect study of the acid-catalyzed hydrolysis of methyl formate. (2005) (15)
- 13C and 15N isotope effects as a probe of the chemical mechanism of Escherichia coli aspartate transcarbamylase. (1992) (14)
- The interaction of liver alcohol dehydrogenase with phenyl adenine dinucleotide, a novel analog of pyridine nucleotide coenzymes. (1978) (14)
- Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme. (2008) (14)
- Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli. (2013) (14)
- A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea. (2010) (14)
- Alteration of the concentrations of dilute palmityl-CoA solutions by surface adsorption. (1969) (14)
- Probing the allosteric activation of pyruvate carboxylase using 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA. (2011) (13)
- Mechanisms of decarboxylation of carboxybiotin (1988) (13)
- Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae. (2012) (13)
- Multiple isotope effect study of the acid-catalyzed hydrolysis of formamide. (2006) (12)
- Magnitude of the equilibrium isotope effect on carbon-tritium bond synthesis. (1977) (12)
- PRIMARY AND SECONDARY OXYGEN-18 ISOTOPE EFFECTS IN THE ALKALINE AND ENZYME-CATALYZED HYDROLYSIS OF PHOSPHOTRIESTERS (1991) (11)
- Aldehyde-induced adenosine triphosphatase activities of fructose 6-phosphate and fructose kinases. (1980) (11)
- 13C isotope effect on the reaction catalyzed by prephenate dehydratase. (2010) (11)
- Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase. (2006) (11)
- Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate. (1998) (11)
- Multiple isotope effect study of the hydrolysis of formamide by urease from jack bean (Canavalia ensiformis). (2006) (10)
- 13C isotope effect studies of Escherichia coli aspartate transcarbamylase in the presence of the bisubstrate analog N-(phosphonoacetyl)-L-aspartate. (1992) (10)
- Properties of 3-hydroxypropionaldehyde 3-phosphate. (1979) (10)
- Roles of Arg427 and Arg472 in the binding and allosteric effects of acetyl CoA in pyruvate carboxylase. (2012) (10)
- Enzymes Enzymes: Physical Principles H. Gutfreund (1973) (9)
- Enzyme kinetics revisited: a commentaryon “The kinetics of enzyme-catalyzed reactions with two or more substrates or products’ by W.W. Cleland Biochim. Biophys. Acta 67 (1963) 104 ff. with Biochim. Biophys. Acta 67 (1963) 173, 188 (summaries) (1989) (9)
- Regiospecificity assignment for the reaction of kanamycin nucleotidyltransferase from Staphylococcus aureus. (2001) (9)
- Separation of aldehydes and ketones by chromatography on Dowex-50 in the ethylenediamine form. (1981) (9)
- The contribution of threonine 55 to catalysis in aspartate transcarbamoylase. (1992) (8)
- A heavy-atom isotope effect and kinetic investigation of the hydrolysis of semicarbazide by urease from jack bean (Canavalia ensiformis). (2008) (8)
- Phosphonate analogue substrates for enolase. (1990) (8)
- Inhibition and kinetic mechanism of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. (1972) (7)
- Enzyme Kinetics: Steady State (2009) (7)
- Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers. (2007) (7)
- Use of isotope effects to determine enzyme mechanisms (2007) (7)
- Chemical mechanism of malic enzyme as determined by isotope effects and alternate substrates (2000) (7)
- Determination of the mechanism of human malic enzyme with natural and alternate dinucleotides by isotope effects. (2001) (7)
- Determination of the absolute configurations of the isomers of triamminecobalt(III) adenosine triphosphate (1986) (7)
- Steady-state kinetic studies of the metal ion-dependent decarboxylation of oxalacetate catalyzed by pyruvate kinase. (1989) (6)
- EVIDENCE FROM MULTIPLE ISOTOPE EFFECT DETERMINATIONS FOR COUPLED HYDROGEN MOTION AND TUNNELING IN THE REACTION CATALYZED BY GLUCOSE-6-PHOSPHATE DEHYDROGENASE (1985) (6)
- 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus. (2006) (6)
- 2H, 13C, and 15N kinetic isotope effects on the reaction of the ammonia-rescued K258A mutant of aspartate aminotransferase. (2003) (6)
- Structures of the meridional and facial isomers of triamminechromium pyrophosphate dihydrate. (1990) (5)
- Carbon-13 isotope effects on reactions involving carbamate and carbamoyl phosphate. (1988) (5)
- N-hydroxycarbamate is the substrate for the pyruvate kinase catalyzed phosphorylation of hydroxylamine. (1984) (5)
- 2-Keto-3-fluoroglutarate: a useful mechanistic probe of 2-keto-glutarate-dependent enzyme systems. (1987) (5)
- Enzyme kinetics: by Irwin H. Segel, published by Wiley and Sons, New York, £17.05 ($34.10) (xxii + 957 pages) (1976) (5)
- Solvent isotope effects on the reaction catalyzed by yeast hexokinase. (1983) (4)
- The effect of oligomeric environment on the kinetics of lactate dehydrogenase subunits. (1982) (4)
- Mechanistic studies of phosphoenolpyruvate carboxylase from Zea mays utilizing formate as an alternate substrate for bicarbonate. (1992) (4)
- Initial velocity analysis for terreactant mechanisms. (1982) (4)
- Characterization of isomers of monoamminechromium-ATP and their use in mapping enzyme active sites. (1993) (4)
- Investigation of substrate specificity of creatine kinase using chromium (III) and cobalt(III) complexes of adenosine 5'-diphosphate. (1984) (4)
- Mechanisms of aldehyde-induced adenosinetriphosphatase activities of kinases. (1984) (4)
- Secondary 18O Isotope Effects as a Tool for Studying Reactions of Phosphate Mono‐, Di‐, and Triesters (1991) (4)
- Effect of the presence of a reversible inhibitor on the time course of slow-binding inhibition. (1987) (4)
- Phosphorylated thiosugars: synthesis, properties, and reactivity in enzymatic reactions. (1991) (4)
- Initial Rate Enzyme Kinetics.Herbert J. Fromm (1977) (3)
- Initial Velocity Studies in the Absence of Added Inhibitors (2007) (3)
- Determination of the absolute configurations of the isomers of triamminecobalt(III) adenosine triphosphate [Erratum to document cited in CA105(3):20891F] (1988) (2)
- Structures of the monohydrate and dihydrate of (bidentate pyrophosphato) trans-diammine cis-diaqua chromium (III). (1990) (2)
- Exchange rates of the amide protons of d-biotin sulfoxide stereoisomers (1987) (2)
- Determination of the screw sense specificity of bovine liver fructokinase. (1985) (2)
- pH profile for the mutarotation of 6-thio-d-fructose (1980) (2)
- A 50-cm-path-length spectrophotometer cuvette for enzyme kinetic studies. (1981) (2)
- Triamminemonoaquocobalt(III) complexes of pyrophosphate and adenosine diphosphate (ADP). (1989) (2)
- Synthesis of (2R,3R)-erythro- and (2R,3S)-threo-fluoromalate using malic dehydrogenase; stereoselectivity of malic dehydrogenase. (1998) (2)
- [7] Kinetic method for determination of dissociation constants nucleotide complexes (1995) (2)
- CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-PHENYLALANINE TRIFLUOROMETHYL KETONE BOUND AT THE ACTIVE SITE (2000) (1)
- Kinetic method for determination of dissociation constants of metal ion-nucleotide complexes. (1995) (1)
- The use of chromium(III) and cobalt(III) complexes of adenosine diphosphate to elucidate the catalytic mechanisms of creatine kinase (1983) (1)
- Deuterium Isotope Effects on the Presteady State Burstofan Enzymatic Reaction (1989) (1)
- Inhibition kinetics of D-glyceraldehyde 3-phosphate dehydrogenase. (1971) (1)
- Characterization of ammine and aquo substituted chromium pyrophosphates by ion exchange chromatography (1993) (1)
- Mechanisms of Decarboxylation of Carboxybiotin. (1988) (1)
- Triamminechromium(III) complexes of tripolyphosphate and adenosine tri- and diphosphate (1991) (1)
- Enzymatic synthesis and inhibitory characteristics of tartronate semialdehyde phosphate. (1989) (1)
- Deuterium isotope effects on lactate dehydrogenase using L-2-hydroxysuccinamate and effect of an inhibitor in the variable substrate on observed isotope effects. (1980) (1)
- Determination of the Absolute Configurations of the Isomers of Triamminecobalt(III) Adenosine Triphosphate. (1986) (0)
- 25 – Kinetics of Aminoacyl-tRNA1 Synthetases Catalyzed ATP-PPi Exchange2 (1981) (0)
- 13C Carbon Isotope Effects on the Metal Ion Catalyzed Decarboxylationof Oxalacetate (1987) (0)
- Crystal Structure of DesIV double mutant (dTDP-glucose 4,6-dehydratase) from Streptomyces venezuelae with NAD and DAU bound (2004) (0)
- Isotope Effects on the Hydrolysis of Cobalt (II)-Bound Phosphate Esters (1994) (0)
- Studies on biotin dependent carboxylases and the properties of carboxybiotin (1986) (0)
- Substrate Binding, Catalysis, and Product Release (2013) (0)
- Determination of equilibrium isotope effects by the equilibrium perturbation method. (1982) (0)
- Enzyme Kinetics: Behavior of Enzyme Systems . John M. Reiner. Second edition. Van Nostrand Reinhold, New York, 1969. xviii + 350 pp., illus. $14.50. (1969) (0)
- Co(III) and Zn(II) Catalyzed Hydrolysis ofPhosphodiesters (1999) (0)
- Mechanistic Probes of Acyl andPhosphoryl Transfer Reactions Using Heavy Atom Isotope Effects (1993) (0)
- Alkaline Phosphatase Catalyzes the Hydrolysis of Glucose 6-Phosphate via a Dissociative Mechanism (1989) (0)
- Crystal Structure of DesIV (dTDP-glucose 4,6-dehydratase) from Streptomyces venezuelae with NAD and TYD bound (2004) (0)
- Introduction to Kinetics (2007) (0)
- Comprehensive enzyme tome (1976) (0)
- The pyruvate carboxylase tetramer - a complex machine (2008) (0)
- Pre-Steady-State and Relaxation Kinetics (2007) (0)
- Enzyme Kinetics. (Book Reviews: Behavior of Enzyme Systems) (1969) (0)
- X-ray crystal structure of PerB from Caulobacter crescentus in complex with CoA and GDP-perosamine at 1.0 Angstrom resolution (2012) (0)
- 1,4‐Dithiothreitol (2001) (0)
- Mechanism of yeast magnesium enolase (1980) (0)
- Stereochemical basis for the four isomers of bidentate chromium ATPγS (1984) (0)
- Determination of the Transition States for Phosphoryl Transferand Hydrolysis Reactions (1990) (0)
- The Mechanism of Aldehyde-Induced ATPase Activities of Kinases (1981) (0)
- alpha-D-glucose-1-phosphate cytidylyltransferase complexed with CTP (2005) (0)
- X-ray crystal structure of the H141A mutant of GDP-perosamine N-acetyl transferase from Caulobacter crescentus in complex with CoA and GDP-perosamine (2012) (0)
- Secondary Oxygen-18 Isotope Effects on PhosphodiesterHydrolysis Reactions (1990) (0)
- Benzoylformate analogues exhibit differential rate-determining steps in the benzoylformate decarboxylase reaction (1987) (0)
- Carbon isotope effect studies of the role of the metal ion in TPN malic enzyme (1985) (0)
- Erratum: Determination of the absolute configurations of the isomers of triamminecobalt(III) adenosine triphosphate (Journal of the American Chemical Society (1986) 108, (4167-4171)) (1988) (0)
- X-ray crystal structure of PerB from Caulobacter crescentus in complex with coenzyme A and GDP-N-acetylperosamine at 1 Angstrom resolution (2012) (0)
- CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-LEUCIL-PHENYLALANINE ALDEHYDE BOUND AT THE ACTIVE SITE (2000) (0)
- Stability constants and dissociation rate constants for Mg2+ and Cd2+ complexes of adenine nucleotides (1984) (0)
- Reaction between CO/sub 2/ and phosphate to form carboxyphosphate (1986) (0)
- X-ray structure of GDP-perosamine N-acetyltransferase in complex with transition state analog at 0.9 Angstrom resolution (2012) (0)
- Solution and Enzymatic Phosphoryl Transfer Reactions ofPhosphodiesters: Characterization of Transition States by Heavy Atom Isotope Effects (1991) (0)
- Enzyme kinetics. (1967) (0)
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