Walter Becker
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Walter Beckercomputer-science Degrees
Computer Science
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Computational Linguistics
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Machine Learning
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Computer Science
Walter Becker's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Walter Becker's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. (2001) (307)
- Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases* (1998) (272)
- The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. (2001) (260)
- Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII (*) (1996) (259)
- Specificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A* (2000) (222)
- Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation (2009) (221)
- Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. (1999) (214)
- Activation, regulation, and inhibition of DYRK1A (2011) (184)
- Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A. (2001) (170)
- JIP60, a methyl jasmonate-induced ribosome-inactivating protein involved in plant stress reactions. (1994) (160)
- The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation (2014) (130)
- Differences in gene expression between natural and artificially induced leaf senescence (2004) (130)
- Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines (2004) (123)
- Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. (1994) (122)
- Cloning of a Novel Family of Mammalian GTP-binding Proteins (RagA, RagBs, RagB1) with Remote Similarity to the Ras-related GTPases * (1995) (119)
- Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters. (1999) (112)
- Characterization of Cyclin L2, a Novel Cyclin with an Arginine/Serine-rich Domain (2004) (110)
- Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling (2011) (105)
- Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. (2002) (104)
- Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. (1997) (99)
- The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site (2006) (85)
- The identification of leaf thionin as one of the main jasmonate-induced proteins of barley (Hordeum vulgare) (1992) (85)
- Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control (2012) (83)
- DYRK1A: a potential drug target for multiple Down syndrome neuropathologies. (2014) (81)
- The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. (2003) (77)
- The MNB/DYRK1A protein kinase: genetic and biochemical properties. (2003) (76)
- 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A (2015) (75)
- Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (1999) (69)
- STAT3 is enriched in nuclear bodies (2004) (64)
- The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4 (2008) (64)
- A complex interaction pattern of CIS and SOCS2 with the leptin receptor (2006) (61)
- Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. (1994) (61)
- Characterisation of the mouse diabetes susceptibility locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat (2002) (60)
- Mechanism of dual specificity kinase activity of DYRK1A (2013) (54)
- DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. (2003) (52)
- Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties. (2003) (48)
- Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity* (2010) (47)
- Unusual function of the activation loop in the protein kinase DYRK1A. (2003) (45)
- Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors (2015) (44)
- DYRK protein kinases (2015) (39)
- Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and GlutathioneS-Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population (2002) (38)
- A wake‐up call to quiescent cancer cells – potential use of DYRK1B inhibitors in cancer therapy (2018) (36)
- Mechanism of attenuation of leptin signaling under chronic ligand stimulation (2010) (35)
- The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2 (2016) (34)
- Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis. (2004) (34)
- Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini. (1996) (31)
- Isolation and characterization of a cDNA clone encoding a novel jasmonate-induced protein of barley (Hordeum vulgare L.) (1992) (30)
- Leptin induces inflammation-related genes in RINm5F insulinoma cells (2007) (30)
- Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-g on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways (1996) (29)
- Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. (1996) (28)
- Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1 (2008) (28)
- Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK) (2015) (26)
- Characterization of cyclin L1 as an immobile component of the splicing factor compartment (2007) (26)
- The rabbit ileal lipid-binding protein. Gene cloning and functional expression of the recombinant protein. (1996) (22)
- Substitution of conserved tyrosine residues in helix 4 (Y143) and 7 (Y293) affects the activity, but not IAPS‐forskolin binding, of the glucose transporter GLUT4 (1994) (22)
- Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism (2018) (21)
- DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain (2017) (20)
- The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. (1998) (18)
- Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain. (1998) (18)
- NGF Upregulates the Plasminogen Activation Inhibitor-1 in Neurons via the Calcineurin/NFAT Pathway and the Down Syndrome-Related Proteins DYRK1A and RCAN1 Attenuate This Effect (2013) (17)
- Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese [db/db mice, fa/fa rats) rodents (1996) (17)
- Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases. (1996) (17)
- Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design (2018) (17)
- cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis. (1996) (15)
- Distribution of the mRNA for protein phosphatase T in rat brain. (1996) (13)
- Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. (2018) (13)
- Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes (2010) (12)
- Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification. (2018) (11)
- Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors (2011) (11)
- Evidence that reduced leptin levels, but not an aberrant sequence of leptin or its receptor, contribute to the obesity syndrome in NON mice. (1996) (10)
- Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands (1995) (9)
- Recent insights into the function of DYRK1A (2011) (8)
- Characterization of Cyclin L 2 , a Novel Cyclin with an Arginine / Serine-rich Domain PHOSPHORYLATION (2004) (8)
- Heterogeneity of insulin receptors in rat tissues as detected with the partial agonist B29,B29'-suberoyl-insulin. (1993) (8)
- How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition—The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine (2020) (8)
- Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects. (2021) (6)
- [Clinical significance of leptin]. (2008) (5)
- Preparation of recombinant histone H3 as a substrate for protein kinase assays. (1999) (4)
- The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN (2021) (4)
- Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A (2018) (4)
- Cloning and functional characterization of the ovine malic enzyme promoter. (2009) (3)
- Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. (2021) (3)
- Transient expression of Mnb / Dyrk 1 A couples cell cycle exit and neuronal differentiation of neuronal precursors in the vertebrate CNS by inducing p 27 KIP 1 expression and suppressing NOTCH signaling (2011) (2)
- Novel harmine analogues and the effect on dual specificity kinase activity of DYRK1A (2015) (2)
- [Minibrain/DYRK1A gene: candidate gene for mental retardation in Down's syndrome?]. (2000) (2)
- Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B (2022) (2)
- Identification and characterization of a new splice variant of the protein kinase DYRK4 and the role of DYRK1A during mitotic exit (2011) (1)
- Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK) (2015) (0)
- The protein kinase DYRK1A increases α-secretase activity in neuronal cells and accelerates cleavage of amyloid precursor protein (2011) (0)
- Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A (2018) (0)
- Differential activation of signalling pathways by the intracellular tyrosines of the leptin receptor (2004) (0)
- Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK 1 A Esti (2018) (0)
- The protein kinase DYRK1A regulates cell cycle progression, neuronal differentiation, and stability of the proteins p27 Kip1, Cyclin D1 and Septin4 (2014) (0)
- Leptin receptor desensitization does not depend on SOCS 3 (2005) (0)
- Post-receptor resistance to leptin in New Zealand Obese mice (2009) (0)
- Phosphorylation of splicing factor 3b1 (SF3b1) by the protein kinase DYRK1A (2005) (0)
- DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain (2017) (0)
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