Walter Gilbert
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American biochemist
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#23
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#33
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Biology
Why Is Walter Gilbert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Walter Gilbert is an American biochemist, physicist, molecular biology pioneer, and Nobel laureate. Education and early life Walter Gilbert was born in Boston, Massachusetts, on March 21, 1932, into a Jewish family, the son of Emma , a child psychologist, and Richard V. Gilbert, an economist.
Walter Gilbert's Published Works
Published Works
- Sequencing end-labeled DNA with base-specific chemical cleavages. (1980) (10425)
- Genomic sequencing. (1984) (5181)
- A new method for sequencing DNA. (1977) (4201)
- Origin of life: The RNA world (1986) (2090)
- Why genes in pieces? (1978) (1906)
- Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis (1988) (1475)
- Molecular basis of base substitution hotspots in Escherichia coli (1978) (1100)
- Mapping adenines, guanines, and pyrimidines in RNA. (1977) (921)
- Nucleotide sequence of rous sarcoma virus (1983) (757)
- A sodium-potassium switch in the formation of four-stranded G4-DNA (1990) (668)
- B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. (1985) (666)
- DNA sequencing at 40: past, present and future (2017) (645)
- E. coli RNA polymerase interacts homologously with two different promoters (1980) (637)
- ISOLATION OF THE LAC REPRESSOR (1966) (555)
- The evolution of spliceosomal introns: patterns, puzzles and progress (2006) (555)
- The evolution of genes: the chicken preproinsulin gene (1980) (527)
- Hepatitis B virus genes and their expression in E. coli (1979) (504)
- Unstable Ribonucleic Acid Revealed by Pulse Labelling of Escherichia Coli (1961) (490)
- The genetic data environment an expandable GUI for multiple sequence analysis (1994) (482)
- STREPTOMYCIN, SUPPRESSION, AND THE CODE. (1964) (408)
- The exon theory of genes. (1987) (405)
- The nucleotide sequence of the lac operator. (1973) (383)
- DNA replication: the rolling circle model. (1968) (382)
- The structure and evolution of the two nonallelic rat preproinsulin genes (1979) (371)
- A bacterial clone synthesizing proinsulin. (1978) (354)
- Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. (1978) (334)
- Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7. (1980) (325)
- Chemical probes for higher-order structure in RNA. (1980) (320)
- Mutants that make more lac repressor. (1968) (318)
- Polypeptide synthesis in Escherichia coli. II. The polypeptide chain and S-RNA. (1963) (303)
- Ligands for ErbB-family receptors encoded by a neuregulin-like gene (1997) (298)
- MSI and MSII made on Ribosome in Idling Step of Protein Synthesis (1972) (271)
- Construction of plasmids carrying the cI gene of bacteriophage lambda. (1976) (267)
- On the antiquity of introns (1986) (260)
- Intron phase correlations and the evolution of the intron/exon structure of genes. (1995) (260)
- Cell-type-specific contacts to immunoglobulin enhancers in nuclei (1985) (253)
- The lac operator is DNA. (1967) (238)
- Origin of genes. (1997) (235)
- One-sided polymerase chain reaction: the amplification of cDNA. (1989) (225)
- Absence of polymorphism at the ZFY locus on the human Y chromosome. (1995) (224)
- Large-scale comparison of intron positions in mammalian genes shows intron loss but no gain (2003) (213)
- How big is the universe of exons? (1990) (209)
- Rates of intron loss and gain: implications for early eukaryotic evolution. (2005) (208)
- Large-scale comparison of intron positions among animal, plant, and fungal genes (2002) (201)
- Retinoic acid is necessary for development of the ventral retina in zebrafish. (1994) (199)
- Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. (1998) (183)
- Eukaryotic signal sequence transports insulin antigen in Escherichia coli. (1980) (176)
- Polypeptide synthesis in Escherichia coli. I. Ribosomes and the active complex. (1963) (161)
- Rous sarcoma virus genome is terminally redundant: the 5' sequence. (1977) (160)
- The triosephosphate isomerase gene from maize introns antedate the plant-animal divergence (1986) (155)
- Complex early genes. (2005) (146)
- Towards a paradigm shift in biology (1991) (145)
- Starting and Stopping Sequences for the RNA Polymerase (1976) (143)
- Cellular location affects protein stability in Escherichia coli. (1982) (140)
- THE BINDING OF S-RNA BY ESCHERICHIA COLI RIBOSOMES. (1963) (139)
- The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: Implication of in vivo functions for this novel DNA structure (1994) (139)
- EID: the Exon?Intron Database?an exhaustive database of protein-coding intron-containing genes (2000) (137)
- Climate change and the integrity of science. (2010) (137)
- Evolution of the intron-exon structure of eukaryotic genes. (1995) (133)
- DNA-binding site of lac repressor probed by dimethylsulfate methylation of lac operator. (1979) (133)
- On the ancient nature of introns. (1993) (131)
- The pattern of intron loss. (2005) (126)
- Bacteria mature preproinsulin to proinsulin. (1980) (120)
- “Useful Proteins from Recombinant Bacteria” (1980) (117)
- Intron positions correlate with module boundaries in ancient proteins. (1996) (116)
- Immunological screening method to detect specific translation products. (1978) (111)
- Intron/exon structure of the chicken pyruvate kinase gene (1985) (108)
- An amino-terminal fragment of lac repressor binds specifically to lac operator. (1978) (107)
- Molecular and biological characterization of messenger RNA. (1961) (105)
- Relationship between "proto-splice sites" and intron phases: evidence from dicodon analysis. (1998) (102)
- Pioneer neurons in the mouse trigeminal sensory system. (1990) (99)
- Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene. (1981) (99)
- Regularities of context-dependent codon bias in eukaryotic genes. (2002) (97)
- Phylogenetic analysis of RNA editing: a primitive genetic phenomenon. (1994) (94)
- Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology (1995) (92)
- The Most Conserved Genome Segments for Life Detection on Earth and Other Planets (2008) (90)
- An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A (2014) (90)
- Exon shuffling and the origin of the mitochondrial targeting function in plant cytochrome c1 precursor. (1996) (90)
- Contacts between the lac repressor and the thymines in the lac operator. (1977) (89)
- Reaction energetics of a mutant triosephosphate isomerase in which the active-site glutamate has been changed to aspartate. (1986) (89)
- A Yeast Gene Product, G4p2, with a Specific Affinity for Quadruplex Nucleic Acids (*) (1995) (83)
- Active site of triosephosphate isomerase: in vitro mutagenesis and characterization of an altered enzyme. (1985) (80)
- Identification and characterization of a nuclease activity specific for G4 tetrastranded DNA. (1993) (78)
- Detection of cytosine methylation in the maize alcohol dehydrogenase gene by genomic sequencing (1986) (76)
- Mystery of intron gain. (2003) (75)
- Primary structure of chicken muscle pyruvate kinase mRNA. (1983) (73)
- Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening. (1995) (73)
- Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells. (1984) (71)
- DNA sequencing and gene structure. (1981) (67)
- Sequences of controlling regions of the lactose operon. (1974) (67)
- Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing (1979) (66)
- Recent Experiences in the Rapid Identification of Bacterium coli Type I (1948) (66)
- RNA editing as a source of genetic variation (1993) (62)
- Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene (1985) (62)
- Resolution of a deep animal divergence by the pattern of intron conservation. (2005) (62)
- Introns and gene evolution (1996) (59)
- A fate map for the first cleavages of the zebrafish (1993) (58)
- STRUCTURE OF THE VERTEX FUNCTION (1959) (58)
- Broken Symmetries and Massless Particles (1964) (58)
- Promoter region for yeast 5S ribosomal RNA (1977) (57)
- Active transposition in zebrafish. (1996) (57)
- Chicken triosephosphate isomerase complements an Escherichia coli deficiency. (1985) (57)
- Rous sarcoma virus encodes a transcriptional activator (1985) (57)
- DNA trapping electrophoresis (1990) (56)
- Detection in vivo of protein-DNA interactions within the lac operon of Escherichia coli (1985) (54)
- An ‘internal” signal sequence directs secretion and processing of proinsulin in bacteria (1981) (53)
- Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. (1997) (52)
- Intron distribution difference for 276 ancient and 131 modern genes suggests the existence of ancient introns (2001) (51)
- Production of immunologically active surface antigens of hepatitis B virus by Escherichia coli. (1981) (50)
- Estimating the Age of the Common Ancestor of Men from the ZFY Intron (1996) (49)
- Discovery of amphibian Tc1-like transposon families. (1996) (49)
- INTRONS AND EXONS: PLAYGROUNDS OF EVOLUTION (1979) (48)
- Neuronal differentiation and maturation in the mouse trigeminal sensory system, in vivo and in vitro (1991) (47)
- [39] Lac Repressor from Escherichia coli (1971) (45)
- Basic protein enhances the incorporation of DNA into lipid vesicles: model for the formation of primordial cells. (1987) (45)
- Large scale bacterial gene discovery by similarity search (1994) (44)
- The fates of the blastomeres of the 16-cell zebrafish embryo. (1994) (44)
- Lactose Operator Sequences and the Action of Lac Repressor (1975) (43)
- Centripetal modules and ancient introns. (1999) (43)
- The limited universe of exons (1991) (43)
- Localization of an acetylcholine receptor intron to the nuclear membrane. (1990) (42)
- Germ-line MuLV reintegrations in AKR/J mice (1982) (41)
- The structure of telomeric DNA: DNA quadriplex formation (1991) (37)
- Differential expression of acetylcholine receptor mRNA in nuclei of cultured muscle cells. (1989) (35)
- A Novel Yeast Gene Product, G4p1, with a Specific Affinity for Quadruplex Nucleic Acids (*) (1995) (34)
- The monoclonal antibody B30 recognizes a specific neuronal cell surface antigen in the developing mesencephalic trigeminal nucleus of the mouse (1989) (32)
- Dealing with database explosion: a cautionary note. (1997) (30)
- CONNECTION BETWEEN GAUGE INVARIANCE AND MASS (1962) (30)
- Direct genomic sequencing of bacterial DNA: the pyruvate kinase I gene of Escherichia coli. (1989) (29)
- New Dispersion Relations for Pion-Nucleon Scattering (1957) (28)
- The Yeast Splice Site Revisited: New Exon Consensus from Genomic Analysis (1997) (28)
- The genomic sequencing technique. (1985) (26)
- Phylogenetically older introns strongly correlate with module boundaries in ancient proteins. (2003) (25)
- Preferential protection of the minor groove of non-operator DNA by lac repressor against methylation by dimethyl sulphate (1976) (24)
- 9 Introns and the RNA World (1999) (23)
- Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. (1996) (23)
- Footprints of primordial introns on the eukaryotic genome. (2001) (22)
- The correlation between introns and the three-dimensional structure of proteins. (1997) (20)
- The signal of ancient introns is obscured by intron density and homolog number (2002) (19)
- Do introns favor or avoid regions of amino acid conservation? (2002) (18)
- The B30 ganglioside is a cell surface marker for neural crest-derived neurons in the developing mouse. (1991) (18)
- Delta-interacting protein A and the origin of hepatitis delta antigen. (1997) (18)
- DNA sequencing and gene structure (1981) (17)
- Structure of the Forward Scattering Amplitude (1960) (17)
- A new method for sequencing DNA. 1977. (1992) (16)
- A novel zebrafish gene expressed specifically in the photoreceptor cells of the retina. (1997) (15)
- Protein Synthesis in Escherichia Coli (1963) (15)
- Zebrafish embryology and neural development. (1991) (13)
- Evolution of antibodies: The road not taken (1986) (13)
- 2 CHEERS FOR HUMAN-GENE SEQUENCING (1986) (13)
- Retinoic acid in the anteroposterior patterning of the zebrafish trunk (1995) (12)
- Studies on Methylated Bases in Transfer RNA (1963) (11)
- THE STRUCTURE OF RAT PREPROINSULIN GENES (1980) (11)
- More Haemophilus and Mycoplasma genes. (1996) (11)
- The Fate of Industrial Carbon Dioxide (2004) (10)
- The boundaries of partially edited transcripts are not conserved in kinetoplastids: implications for the guide RNA model of editing. (1993) (10)
- One-sided anchored polymerase chain reaction for amplification and sequencing of complementary DNA. (1993) (9)
- The Universe of Exons Revisited (2003) (9)
- Simultaneous visualization of neuronal protein and receptor mRNA. (1990) (8)
- Spatial domains in the developing forebrain: developmental regulation of a restricted cell surface protein. (1991) (8)
- Introns and the RNA World (2005) (8)
- Science Over Politics (1999) (8)
- Erratum to: An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A (2016) (8)
- Projections of probability distributions (1955) (8)
- The genomic structure of C14orf1 is conserved across eukarya (2000) (8)
- Life after the helix (2003) (8)
- The lac repressor and the lac operator. (2008) (7)
- Factors released by ciliary neurons and spinal cord explants induce acetylcholine receptor mRNA expression in cultured muscle cells. (1990) (7)
- Genomic sequencing ( DNA methylation / UV crosslinking / filter hybridization / immunoglobulin genes ) (7)
- Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. (1990) (6)
- Recombinant DNA research: government regulation. (1977) (6)
- DNA sequencing, today and tomorrow. (1991) (6)
- Genetic repressors. (1970) (5)
- Large-scale genomic sequencing: optimization of genomic chemical sequencing reactions. (1995) (5)
- Integral representations of two-point functions (1960) (5)
- Boston colloquium for philosophy of science (2002) (5)
- Yang-Fermi Ambiguity (1956) (4)
- [A method for determining DNA sequence by labeling the end of the molecule and cleaving at the base. Isolation of DNA fragments, end-labeling, cleavage, electrophoresis in polyacrylamide gel and analysis of results]. (1986) (4)
- Publisher Correction: DNA sequencing at 40: past, present and future (2019) (4)
- A bacterial clone synthesizing proinsulin. 1978. (1992) (4)
- Chapter V: The Lactose Repressor (1970) (4)
- The synthesis of insulin in bacteria: a model for the production of medically useful proteins in prokaryotic cells. (1980) (4)
- YEAST MITOCHONDRIAL INTRON PRODUCTS REQUIRED INTRONS FOR RNA SPLICING (1980) (4)
- Sequences of controlling regions of the E. coli lactose operon (1975) (3)
- Nobel laureates' letter to President Bush. (2001) (3)
- The kinetic consequences of altering the catalytic residues of triosephosphate isomerase (1986) (3)
- Response: Estimating the Age of the Common Ancestor of Men from the ZFY Intron (1996) (3)
- THE STRUCTURE AND TRANSCRIPTION OF RAT PREPROINSULIN GENES (1979) (2)
- Toward a resolution of the introns earlyylate debate: Only phase zero introns are correlated with the structure of ancient proteins (introns-earlyyintrons-lateymodules) (1998) (2)
- A new method for sequencing DNA (DNA chemistry/dimethyl sulfate cleavage/hydrazine/piperidine) (2016) (2)
- Walter Gilbert - Selected Works (2020) (2)
- Expression of active polypeptides in E. coli. (1981) (1)
- Human genome sequencing. (1988) (1)
- On generalised dispersion relations II (1956) (1)
- 9and the RNA World (1999) (1)
- Completely monotonic functions on cones (1956) (1)
- On generalized dispersion relations and meson-nucleon scattering (1957) (0)
- A bacterial clone synthesizing proinsulin ( rat preproinsulin / cDNA cloning / solid-phase radioimmunoassay / DNA sequence / fused proteins ) (0)
- 1L1115 Structural features of protein modules and their introns. (2002) (0)
- Evolution Exon shuffling and the origin of the mitochondrial targeting function in plant cytochrome cl precursor ( glyceraldehyde-3-phosphate dehydrogenase / presequences / transit peptides / nucleus-encoded organelle genes ) (2005) (0)
- Evolution Toward a resolution of the introns early y late debate : Only phase zero introns are correlated with the structure of ancient proteins (1998) (0)
- Evolution Intron positions correlate with module boundaries in ancient proteins ( intron evolution y introns-early ) (1996) (0)
- Bacteria mature preproinsulin to proinsulin ( hybrid signal sequences / secretion / signal peptidase / immunoprecipitation / protein processing ) (0)
- Contacts between the lac repressor and thymines in the lac operator ( E . coli genetic control / bromodeoxyuridine substitution / ultraviolet light crosslinking / DNA sequencing ) (0)
- 1964 Gordon Research Conference on Nucleic Acids (2008) (0)
- Invited presentation: introns and modules in ancient conserved genes (abstract only) (2000) (0)
- Mycoplasma capricolum Genome Project (1998) (0)
- Phylogenetic analysis of RNA editing: A primitive (2016) (0)
- DNA sequencing conference, 2 (1991) (0)
- UCLA Symposium on Molecular Evolution (1988) (0)
- Full manuscript with supplementary data (2015) (0)
- Bacteria mature preproinsulin to proinsulin. 1980. (1992) (0)
- Cellular location affects protein sta (2016) (0)
- Foerfarande Foer framstaellning of the protein utvalt (1979) (0)
- Genomic Sequencing STOR (2012) (0)
- More Haemophilus and Mycoplasma Genes (1996) (0)
- Prior to the development of rapid DNA sequencing methods in the early 1970 s by Sanger in England and (0)
- Publisher Correction: DNA sequencing at 40: past, present and future (2019) (0)
- Modular structural units, exons, and function in chicken lysozyme (0)
- Proinsulin from Bacteria (1981) (0)
- Interview with Walter Gilbert by Molly Nicholson and Robert Cook-Deegan (2005) (0)
- Immunological screening method to detect specific translation products. 1978. (1992) (0)
- Testimony of Walter Gilbert (1995) (0)
- Letter to Robert Edgar, Thimann Labs, University of California, Santa Cruz. (1985) (0)
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