Walter J Koch

Q: What Schools Are Affiliated With Walter J Koch

Walter J Koch is affiliated with the following schools: Stanford University, University of North Carolina at Chapel Hill, Temple University, University of Oulu, Heidelberg University, University of Innsbruck, University of Cincinnati, University of California, Berkeley, Kyushu University, University of Cologne, California Institute of Technology, University of Michigan, University of California, San Francisco, Thomas Jefferson University, Kyoto University, Duke University, Imperial College London, Shanxi Medical University

Walter J Koch's AcademicInfluence.com Rankings

Walter J Koch

Biology

#5385

World Rank

#7850

Historical Rank

Molecular Biology

#476

World Rank

#486

Historical Rank

Neuroscience

#595

World Rank

#621

Historical Rank

Biochemistry

#629

World Rank

#723

Historical Rank

biology Degrees

Download Badge

Biology

Walter J Koch's Degrees

PhD Biochemistry University of California, San Francisco
Masters Molecular Biology Stanford University
Bachelors Biology University of California, Berkeley

Similar Degrees You Can Earn

Best Online Bachelor's in Biology 2025

Why Is Walter J Koch Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Walter J Koch's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Seven-transmembrane-spanning receptors and heart function (2002) (978)
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. (1995) (682)
A novel protective effect of erythropoietin in the infarcted heart. (2003) (584)
Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. (2015) (531)
A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse (2010) (529)
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (1998) (524)
Sequence and expression of MRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel (1988) (524)
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. (1998) (491)
Adrenergic Nervous System in Heart Failure: Pathophysiology and Therapy (2013) (479)
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. (2001) (475)
Structure and mechanism of the G protein-coupled receptor kinases. (1993) (455)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (1994) (441)
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. (1993) (431)
Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress (2007) (427)
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. (1999) (419)
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. (1994) (414)
Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress (2002) (404)
Biology of Intracranial Aneurysms: Role of Inflammation (2012) (386)
Animal models of heart failure: a scientific statement from the American Heart Association. (2012) (372)
Distinct Pathways of G- and G-mediated Mitogen-activated Protein Kinase Activation (*) (1995) (370)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (1996) (339)
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure (2008) (339)
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 (2007) (287)
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. (1998) (285)
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice (2015) (283)
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases (1992) (282)
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. (2015) (282)
Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase* (1997) (280)
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure (2001) (258)
Gene therapy in heart failure. (2008) (251)
Catecholamines, Cardiac b-Adrenergic Receptors, and Heart Failure (2000) (237)
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure (2007) (229)
Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (2019) (228)
Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice (1999) (227)
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. (1999) (225)
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. (2004) (223)
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. (1996) (219)
G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure (2008) (219)
cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms. (1990) (215)
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008) (214)
G-protein -Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism (*) (1996) (212)
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction (2000) (210)
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. (1994) (210)
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. (1998) (207)
Myocardial Adeno-Associated Virus Serotype 6–&bgr;ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure (2009) (207)
Gβγ-dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy* (2000) (206)
Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration (1995) (204)
Cardioprotective Effects of Erythropoietin in the Reperfused Ischemic Heart (2004) (203)
Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model (2011) (203)
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. (1997) (203)
In Vivo Ventricular Gene Delivery of a &bgr;-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction (2001) (201)
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. (2001) (194)
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. (2005) (191)
Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor (*) (1995) (190)
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. (1994) (189)
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES* (1996) (189)
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice* (1998) (187)
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. (2013) (184)
Differential gene expression and genomic patient stratification following left ventricular assist device support. (2003) (182)
Stable Myocardial-Specific AAV6-S100A1 Gene Therapy Results in Chronic Functional Heart Failure Rescue (2007) (179)
Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and &bgr;-Adrenergic Signaling (2006) (174)
New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging (2018) (170)
Cardioprotective effects of thioredoxin in myocardial ischemia and the reperfusion role of S-nitrosation (2004) (168)
Functional consequences of altering myocardial adrenergic receptor signaling. (2000) (167)
Gβγ interactions with PH domains and Ras-MAPK signaling pathways (1995) (166)
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. (2016) (166)
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. (2012) (161)
S100A1: A regulator of myocardial contractility (2001) (152)
Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. (2010) (150)
Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart. (2008) (149)
Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Toward Heart Failure After Myocardial Infarction (2006) (149)
Cardiac Overexpression of a Gq Inhibitor Blocks Induction of Extracellular Signal–Regulated Kinase and c-Jun NH2-Terminal Kinase Activity in In Vivo Pressure Overload (2001) (147)
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. (2002) (147)
CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy (2012) (145)
β-Adrenergic Receptor-mediated DNA Synthesis in Cardiac Fibroblasts Is Dependent on Transactivation of the Epidermal Growth Factor Receptor and Subsequent Activation of Extracellular Signal-regulated Kinases* (2002) (144)
Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors (1997) (143)
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. (2013) (143)
Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation (2016) (140)
GRK2 as a novel gene therapy target in heart failure. (2011) (140)
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. (1996) (136)
AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. (2013) (136)
C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart (2012) (134)
G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia (2011) (134)
Transgenic Overexpression of the Ca2+-binding Protein S100A1 in the Heart Leads to Increased in Vivo Myocardial Contractile Performance* (2003) (133)
AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin (2009) (133)
Defective β-Adrenergic Receptor Signaling Precedes the Development of Dilated Cardiomyopathy in Transgenic Mice with Calsequestrin Overexpression* (1999) (132)
Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms (2010) (132)
Pharmacological- and Gene Therapy–Based Inhibition of Protein Kinase Cα/β Enhances Cardiac Contractility and Attenuates Heart Failure (2006) (132)
TNF-α Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Pathology (2013) (131)
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. (2000) (129)
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. (2019) (127)
Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation. (2007) (126)
The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. (2015) (124)
Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture (2012) (121)
SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death (2014) (119)
Ischemic Neoangiogenesis Enhanced by &bgr;2-Adrenergic Receptor Overexpression: A Novel Role for the Endothelial Adrenergic System (2005) (118)
C1q/Tumor Necrosis Factor–Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation (2013) (116)
Comparative Cardiac Gene Delivery of Adeno‐Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart (2010) (112)
Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction* (2010) (111)
Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity (2017) (111)
Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart. (1992) (111)
Ca2+-Dependent Interaction of S100A1 with F1-ATPase Leads to an Increased ATP Content in Cardiomyocytes (2007) (109)
SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. (2015) (108)
The role of oxidative stress in cerebral aneurysm formation and rupture. (2013) (107)
Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction (2015) (105)
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. (2011) (104)
Targeted &bgr;-Adrenergic Receptor Kinase (&bgr;ARK1) Inhibition by Gene Transfer in Failing Human Hearts (2004) (104)
Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase. (1995) (103)
Improved Myocardial &bgr;-Adrenergic Responsiveness and Signaling With Exercise Training in Hypertension (2005) (102)
Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction (2012) (101)
Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting (2013) (101)
Role of Omi/HtrA2 in Apoptotic Cell Death After Myocardial Ischemia and Reperfusion (2005) (101)
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. (2001) (101)
Catecholamines, cardiac beta-adrenergic receptors, and heart failure. (2000) (101)
The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. (1999) (99)
Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. (1988) (99)
S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance. (2007) (99)
Specific β2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the β2AR in Myocytes From Failing Human Heart (2002) (98)
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function (1999) (98)
Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. (2010) (98)
Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice (2012) (97)
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. (2006) (96)
Ischemic Neoangiogenesis Enhanced by β2-Adrenergic Receptor Overexpression (2005) (95)
Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart. (2007) (94)
Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. (1994) (93)
Negative Impact of &bgr;-Arrestin-1 on Post-Myocardial Infarction Heart Failure via Cardiac and Adrenal-Dependent Neurohormonal Mechanisms (2014) (93)
An adrenal β-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo (2009) (92)
Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading. (2006) (92)
Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction (2010) (91)
G protein-coupled receptor kinases in normal and failing myocardium. (2011) (88)
Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization. (2004) (88)
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. (1999) (87)
Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress (2008) (87)
Cardiac Gene Delivery With Cardiopulmonary Bypass (2001) (87)
β-arrestin–biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction (2016) (87)
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. (2005) (86)
β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy Regulation by β- but not α1-Adrenergic Stimulation (1999) (84)
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity. (2008) (84)
A Novel Preclinical Strategy for Identifying Cardiotoxic Kinase Inhibitors and Mechanisms of Cardiotoxicity (2011) (84)
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. (2005) (83)
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. (2000) (83)
21 G-protein-coupled receptors and their regulation (1997) (83)
AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. (2015) (83)
Extracellular S100A1 Protein Inhibits Apoptosis in Ventricular Cardiomyocytes via Activation of the Extracellular Signal-regulated Protein Kinase 1/2 (ERK1/2)* (2003) (83)
Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling(*) (1995) (82)
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. (1997) (82)
Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. (2011) (82)
Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy (2013) (81)
Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy: Short Communication (2012) (80)
Adiponectin Inhibits Tumor Necrosis Factor-&agr;–Induced Vascular Inflammatory Response via Caveolin-Mediated Ceramidase Recruitment and Activation (2014) (80)
Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. (2010) (80)
Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis (2017) (80)
Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury. (2016) (79)
Chronic β-Adrenergic Receptor Stimulation Induces Cardiac Apoptosis and Aggravates Myocardial Ischemia/Reperfusion Injury by Provoking Inducible Nitric-Oxide Synthase-Mediated Nitrative Stress (2006) (77)
G protein-coupled receptor kinases as therapeutic targets in the heart (2019) (77)
Myocardial Gene Transfer and Overexpression of &bgr;2-Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts (2002) (77)
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. (2016) (77)
S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes. (2011) (77)
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. (2001) (75)
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. (1992) (75)
Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3–Dependent Cyclooxygenase-2 Inhibition (2013) (75)
G Protein–Coupled Receptor Kinase 2: A Link Between Myocardial Contractile Function and Cardiac Metabolism (2014) (74)
TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury (2014) (74)
Interleukin-10 Deficiency Alters Endothelial Progenitor Cell–Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment (2019) (73)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (1994) (73)
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. (2007) (73)
Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport. (2004) (73)
Gi-Biased &bgr;2AR Signaling Links GRK2 Upregulation to Heart Failure (2012) (72)
GRK2 inhibition in heart failure: something old, something new. (2012) (72)
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. (1999) (72)
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. (1998) (71)
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility (2013) (71)
GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity (2014) (71)
Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. (2004) (70)
Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. (2000) (69)
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. (2007) (69)
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. (1997) (69)
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases (2017) (69)
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation. (2011) (68)
Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo (2011) (68)
The β-adrenergic receptor kinase in heart failure (2003) (68)
Activation of Liver-X-Receptor &agr; But Not Liver-X-Receptor &bgr; Protects Against Myocardial Ischemia/Reperfusion Injury (2014) (68)
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. (2000) (67)
Differential myocardial gene expression in the development and rescue of murine heart failure. (2003) (67)
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through β2-adrenoceptors (2003) (67)
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes (2005) (67)
Calcium channels from Cyprinus carpio skeletal muscle. (1991) (66)
Gq-Coupled Receptor Agonists Mediate Cardiac Hypertrophy Via the Vasculature (2002) (65)
G Protein–Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning (2004) (65)
Negative Regulation of miR‐375 by Interleukin‐10 Enhances Bone Marrow‐Derived Progenitor Cell‐Mediated Myocardial Repair and Function After Myocardial Infarction (2015) (64)
Heart Failure Gene Therapy: The Path to Clinical Practice (2013) (64)
Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice (2020) (64)
Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction. (1999) (64)
Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System (2017) (64)
&bgr;2-Adrenergic Receptor Gene Delivery to the Endothelium Corrects Impaired Adrenergic Vasorelaxation in Hypertension (2002) (63)
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. (1997) (63)
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. (1999) (63)
&bgr;-Arrestin2 Improves Post–Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase–Dependent Positive Inotropy in Cardiomyocytes (2017) (63)
Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury. (2019) (62)
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. (2013) (60)
Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process (2013) (60)
Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. (2007) (59)
Vascular Endothelial Growth Factor Blockade Prevents the Beneficial Effects of &bgr;-Blocker Therapy on Cardiac Function, Angiogenesis, and Remodeling in Heart Failure (2013) (59)
Level of &bgr;-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure (2005) (58)
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. (2010) (58)
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes (2002) (58)
Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function (1999) (58)
Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy. (2007) (58)
Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. (2003) (58)
Convergence of G Protein–Coupled Receptor and S-Nitrosylation Signaling Determines the Outcome to Cardiac Ischemic Injury (2013) (58)
Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors (2001) (57)
Myocardial β2‐adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure (2012) (57)
Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade (2016) (57)
BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes. (2016) (57)
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. (2004) (57)
Targeting Gβγ Signaling to Inhibit Prostate Tumor Formation and Growth* (2003) (57)
Regulated Overexpression of the A1-Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function (2006) (56)
Ex vivo adenovirus-mediated gene transfer to the adult rat heart. (1998) (54)
Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway (2013) (54)
Future G protein-coupled receptor targets for treatment of heart failure (2009) (54)
Male and female mice overexpressing the β2-adrenergic receptor exhibit differences in ischemia/reperfusion injury: Role of nitric oxide (2002) (54)
Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell–Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium (2017) (53)
Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance. (2015) (53)
The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development. (2016) (52)
&bgr;1-Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 (S1PR1) Reciprocal Downregulation Influences Cardiac Hypertrophic Response and Progression to Heart Failure: Protective Role of S1PR1 Cardiac Gene Therapy (2013) (52)
Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor (2001) (52)
&bgr;-Adrenergic Regulation of Cardiac Progenitor Cell Death Versus Survival and Proliferation (2013) (51)
Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling. (1999) (51)
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. (1996) (51)
Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists. (2008) (51)
Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3. (2011) (51)
Restoration of b-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer (1997) (51)
Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy. (2003) (51)
Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases (2016) (50)
Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration. (2009) (50)
Impaired neoangiogenesis in β2–adrenoceptor gene‐deficient mice: restoration by intravascular human β2–adrenoceptor gene transfer and role of NFκB and CREB transcription factors (2011) (50)
Adrenergic receptors: recent insights into their mechanism of activation and desensitization. (1993) (49)
GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels. (2015) (49)
Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease. (2003) (49)
Cigarette Smoke Modulates Vascular Smooth Muscle Phenotype: Implications for Carotid and Cerebrovascular Disease (2013) (49)
Cardiovascular gene therapy for myocardial infarction (2014) (48)
L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac β2-adrenoceptor (1999) (48)
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. (1995) (48)
Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. (2016) (48)
Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. (2008) (47)
Characterization of cDNA clones encoding two putative isoforms of the α1 subunit of the dihydropyridine‐sensitive voltage‐dependent calcium channel isolated from rat brain and rat aorta (1989) (47)
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. (1995) (47)
Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling. (2011) (47)
Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. (1999) (47)
Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice (2014) (46)
Increasing Cardiac Contractility After Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction (2009) (46)
Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection (2013) (46)
Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction (2019) (46)
The Inotropic Peptide &bgr;ARKct Improves &bgr;AR Responsiveness in Normal and Failing Cardiomyocytes Through G&bgr;&ggr;-Mediated L-Type Calcium Current Disinhibition (2011) (46)
Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. (2002) (46)
Leukocyte-Expressed &bgr;2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury (2016) (45)
Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure (2018) (45)
&bgr;-Arrestin1–Biased &bgr;1-Adrenergic Receptor Signaling Regulates MicroRNA Processing (2014) (45)
Nuclear Effects of G-Protein Receptor Kinase 5 on Histone Deacetylase 5–Regulated Gene Transcription in Heart Failure (2011) (44)
The effect of Gi‐protein inactivation on basal, and β1‐ and β2AR‐stimulated contraction of myocytes from transgenic mice overexpressing the β2‐adrenoceptor (2000) (44)
Aldosterone increases cardiac vagal tone via G protein‐coupled oestrogen receptor activation (2013) (44)
Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. (1995) (44)
Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging (2018) (44)
Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction. (2010) (44)
Adiponectin inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling. (2013) (43)
"Canonical and non-canonical actions of GRK5 in the heart". (2016) (43)
Physiological Induction of a &bgr;-Adrenergic Receptor Kinase Inhibitor Transgene Preserves &bgr;-Adrenergic Responsiveness in Pressure-Overload Cardiac Hypertrophy (2000) (42)
Regulation of Nuclear Factor κB (NF-κB) in the Nucleus of Cardiomyocytes by G Protein-coupled Receptor Kinase 5 (GRK5)* (2013) (42)
Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison (2015) (42)
Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. (1996) (42)
The beta-adrenergic receptor kinase in heart failure. (2003) (42)
Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor*♦ (2015) (42)
G-Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Adiponectin Receptor 1 in Failing Heart (2015) (41)
Native‐type DHP‐sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac α1 subunits expressed in Xenopus laevis ooeytes and are regulated by α2‐ and β‐subunits (1992) (41)
Overexpression of wild‐type Gαi‐2 suppresses β‐adrenergic signaling in cardiac myocytes (2003) (41)
Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor (2014) (41)
Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia (2007) (41)
The adrenergic pathway and heart failure. (2004) (40)
Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling (2017) (40)
Essential Role of Caveolin-3 in Adiponectin Signalsome Formation and Adiponectin Cardioprotection (2011) (40)
Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction (2012) (39)
Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. (2014) (39)
β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury (2016) (39)
A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction (2016) (39)
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. (2005) (39)
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts (2004) (39)
Downregulation of adiponectin induced by tumor necrosis factor &agr; is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury* (2011) (38)
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. (1999) (38)
Endothelial S100A1 Modulates Vascular Function via Nitric Oxide (2006) (38)
Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure. (2016) (38)
A1 Adenosine Receptor Upregulation Accompanies Decreasing Myocardial Adenosine Levels in Mice With Left Ventricular Dysfunction (2007) (37)
Involvement of Nuclear Factor κB (NF-κB) Signaling Pathway in Regulation of Cardiac G Protein-coupled Receptor Kinase 5 (GRK5) Expression* (2012) (37)
INO-4885 [5,10,15,20-Tetra[N-(benzyl-4′-carboxylate)-2-pyridinium]-21H,23H-porphine Iron(III) Chloride], a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice (2009) (36)
Antisense oligonucleotide to proto-oncogene c-myb inhibits the formation of intimal hyperplasia in experimental vein grafts. (1997) (36)
G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. (1995) (36)
A novel and efficient model of coronary artery ligation in the mouse. (2013) (36)
The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury. (2012) (36)
Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. (2011) (36)
Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation (2018) (35)
Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy (2014) (35)
Differential Activation of Cultured Neonatal Cardiomyocytes by Plasmalemmal Versus Intracellular G Protein-coupled Receptor 55* (2013) (35)
Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model (2013) (35)
Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. (2011) (35)
Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy. (2015) (35)
Different potencies of angiotensin receptor blockers at suppressing adrenal β-Arrestin1-dependent post-myocardial infarction hyperaldosteronism. (2014) (35)
Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function (2007) (35)
Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. (2017) (34)
Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. (2004) (34)
Nesfatin‐1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats (2013) (33)
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy. (1999) (33)
Predisposition to Arrhythmia and Autonomic Dysfunction in Nhlh1-Deficient Mice (2002) (33)
Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure (2014) (32)
Gene Therapy Targets in Heart Failure: The Path to Translation (2011) (32)
Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts. (2004) (32)
Cardiac &bgr;ARK1 Upregulation Induced by Chronic Salt Deprivation in Rats (2001) (32)
β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling. (2017) (32)
Toward an understanding of the dihydropyridine-sensitive calcium channel. (1990) (32)
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. (1998) (32)
Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade (2012) (32)
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. (1995) (32)
Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. (2001) (32)
Cardiac-restricted Expression of the Carboxyl-terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth (2008) (32)
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. (2020) (31)
Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes. (2002) (31)
Inhibition of Spontaneous β2-Adrenergic Activation Rescues β1-Adrenergic Contractile Response in Cardiomyocytes Overexpressing β2-Adrenoceptor* (2000) (31)
Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression. (2002) (31)
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. (2002) (31)
Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction. (2012) (31)
Viral-based myocardial gene therapy approaches to alter cardiac function. (2004) (30)
Transgenic studies of cardiac adrenergic receptor regulation. (2001) (30)
Dynamic Changes in Lymphocyte GRK2 Levels in Cardiac Transplant Patients: A Biomarker for Left Ventricular Function (2010) (30)
βARKct: A Therapeutic Approach for Improved Adrenergic Signaling and Function in Heart Disease (2010) (30)
Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. (2012) (30)
&bgr;-Adrenergic Receptor–Mediated Cardiac Contractility Is Inhibited via Vasopressin Type 1A-Receptor–Dependent Signaling (2014) (30)
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets. (2003) (30)
Guidelines for Translational Research in Heart Failure (2015) (30)
Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. (2003) (30)
Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling (2018) (30)
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (1999) (29)
Molecular Scaffolds Regulate Bidirectional Crosstalk Between Wnt and Classical Seven-Transmembrane Domain Receptor Signaling Pathways (2007) (29)
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. (1998) (29)
Pro-Death Signaling of GRK2 in Cardiac Myocytes after Ischemic Stress Occurs via ERK-Dependent, Hsp90-Mediated Mitochondrial Targeting (2013) (29)
Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice (2019) (28)
Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2 (2013) (28)
S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. (2018) (28)
Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts. (2000) (28)
Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation (2013) (28)
Simultaneous Administration of Insulin‐Like Growth Factor‐1 and Darbepoetin Alfa Protects the Rat Myocardium Against Myocardial Infarction and Enhances Angiogenesis (2008) (28)
S100A1 Deficiency Impairs Postischemic Angiogenesis Via Compromised Proangiogenic Endothelial Cell Function and Nitric Oxide Synthase Regulation (2013) (28)
Cardiac AAV 9S 100 A 1 gene therapy rescues postischemic heart failure in a preclinical large animal model (2014) (28)
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. (1997) (28)
Vascular rarefaction in peripheral skeletal muscle after experimental heart failure. (2003) (27)
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy (2017) (27)
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. (2001) (27)
BMP‐2 and FGF‐2 Synergistically Facilitate Adoption of a Cardiac Phenotype in Somatic Bone Marrow c‐kit+/Sca‐1+ Stem Cells (2008) (27)
Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. (2019) (27)
Phospholemman and beta-adrenergic stimulation in the heart. (2010) (26)
β2‐Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels (1999) (26)
Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats. (2007) (26)
Therapeutic potential of G-protein coupled receptor kinases in the heart. (1999) (26)
Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. (2014) (26)
Persistent increases in Ca2+ influx through Cav1.2 shortens action potential and causes Ca2+ overload-induced afterdepolarizations and arrhythmias (2015) (25)
GRK2 negatively regulates IGF‐1R signaling pathway and cyclins' expression in HepG2 cells (2013) (25)
Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective. (2019) (25)
Cardiac‐Restricted Overexpression of the A2A‐Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A1‐Adenosine Receptor (2008) (24)
Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. (2012) (24)
Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury (2019) (24)
Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction. (1999) (24)
Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. (2000) (24)
Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice (1996) (23)
p38α regulates SERCA2a function. (2014) (23)
Beta blocker specificity: a building block toward personalized medicine. (2007) (23)
Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. (2015) (23)
Cardiac‐Specific Disruption of Bin1 in Mice Enables a Model of Stress‐ and Age‐Associated Dilated Cardiomyopathy (2015) (23)
Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor. (2012) (23)
Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. (2015) (23)
Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. (2010) (23)
GRK5 is a regulator of fibroblast activation and cardiac fibrosis (2021) (23)
Changes of plasma norepinephrine and serum N-terminal pro-brain natriuretic peptide after exercise training predict survival in patients with heart failure. (2014) (23)
Adenoviral-mediated inhibition of Gβγ signaling limits the hyperplastic response in experimental vein grafts (1998) (22)
Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling. (2017) (22)
Myocardial gene transfer (2001) (22)
A possible role for the endothelium in porcine coronary smooth muscle responses to dihydropyridine calcium channel modulators. (1987) (22)
Targeting G bg signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis (1999) (22)
Developing Strategies to Link Basic Cardiovascular Sciences with Clinical Drug Development: Another Opportunity for Translational Sciences (2007) (21)
S100A1: a calcium-modulating inotropic prototype for future clinical heart failure therapy. (2007) (21)
Genetic and phenotypic targeting of β-adrenergic signaling in heart failure (2004) (21)
Structure–activity relationship study of angiotensin II analogs in terms of β‐arrestin‐dependent signaling to aldosterone production (2016) (21)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by GBy activation of p 2 lras (2005) (21)
Paroxetine‐mediated GRK2 Inhibition Reverses Cardiac Dysfunction and Remodeling Post‐Myocardial Infarction (2015) (20)
Male and female mice overexpressing the beta(2)-adrenergic receptor exhibit differences in ischemia/reperfusion injury: role of nitric oxide. (2002) (20)
Designer Approaches for G Protein–Coupled Receptor Modulation for Cardiovascular Disease (2018) (20)
Direct evidence of intracrine angiotensin II signaling in neurons. (2014) (20)
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. (2007) (20)
Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). (2013) (20)
Vascular β -Adrenergic Receptor Adenylyl Cyclase System in Maturation and Aging (2000) (20)
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. (2008) (20)
Cardioprotection of Controlled and Cardiac-Specific Over-Expression of A2A-Adenosine Receptor in the Pressure Overload (2012) (19)
Intracellular Endothelin Type B Receptor-driven Ca2+ Signal Elicits Nitric Oxide Production in Endothelial Cells* (2012) (19)
Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. (2003) (19)
Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism (2008) (19)
Impact of Paroxetine on Proximal β‐adrenergic Receptor Signaling (2017) (19)
Right ventricular gene therapy with a beta-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding. (2001) (19)
Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy (2002) (19)
Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the β‐adrenergic receptor kinase (βARK1) (2005) (19)
The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor. (2000) (19)
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G‐protein‐coupled receptor kinase 2 (2012) (19)
Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction. (2019) (18)
Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase. (1998) (18)
Preservation of myocardial b-adrenergic receptor signaling delays the development of heart failure after myocardial infarction (2000) (18)
Induced overexpression of Na(+)/Ca(2+) exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction. (2013) (18)
Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts (2014) (18)
The Inotropic Peptide (cid:1) ARKct Improves (cid:1) AR Responsiveness in Normal and Failing Cardiomyocytes Through G (cid:1)(cid:2) -Mediated L-Type Calcium Current Disinhibition (2010) (18)
Consequence of the tumor-associated conversion to cyclin D1b (2015) (18)
Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure. (2004) (18)
Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein–Coupled Receptor Kinase 2 Inhibitors (2017) (18)
G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart. (2018) (17)
α2-Adrenergic receptor subtype-specific activation of NF-κB in PC12 cells (2006) (17)
Cardiac Dysfunction in HIV‐1 Transgenic Mouse: Role of Stress and BAG3 (2015) (17)
A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic. (2011) (17)
Prior β-blocker treatment decreases leukocyte responsiveness to injury. (2019) (16)
Alteration of myocardial GRK2 produces a global metabolic phenotype. (2014) (16)
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. (1996) (16)
MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction (2013) (16)
β -Adrenergic Regulation of Cardiac Progenitor Cell Death Versus Survival and Proliferation (2012) (16)
GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease. (2018) (16)
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. (1999) (16)
Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. (2014) (16)
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. (2017) (16)
Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding. (2004) (16)
Cardiac hypertrophy and altered β-adrenergic signaling in transgenic mice that express the amino terminus of β-ARK1 (2003) (16)
Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans. (2017) (15)
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe (2019) (15)
Phospholemman and -adrenergic stimulation in the heart (2010) (15)
Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets (2021) (15)
Catheter‐mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method (2005) (15)
Myocardial overexpression of adrenergic receptors and receptor kinases. (1998) (15)
GRK2 in the heart: a GPCR kinase and beyond. (2014) (15)
S 100 A 1 Gene Therapy Preserves in Vivo Cardiac Function after Myocardial Infarction (2005) (14)
Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts. (2002) (14)
Sealing the leak, healing the heart (2003) (14)
Gene therapy approaches to cardiovascular disease. (2005) (14)
GRK2 and GRK5 as therapeutic targets and their role in maladaptive and pathological cardiac hypertrophy (2019) (14)
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. (2008) (14)
S100A1 gene transfer in myocardium. (2006) (14)
S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. (2015) (14)
Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism (2019) (13)
G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure (2021) (13)
β2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery (2004) (13)
Gene transfer strategies for augmenting cardiac function. (1997) (13)
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. (2019) (13)
Role of Omi / HtrA 2 in Apoptotic Cell Death After Myocardial Ischemia and Reperfusion (2004) (13)
Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation. (2002) (13)
Urotensin II promotes vagal‐mediated bradycardia by activating cardiac‐projecting parasympathetic neurons of nucleus ambiguus (2014) (13)
PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein–coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro (2018) (12)
β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia (2016) (12)
Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. (2003) (12)
Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance. (2014) (12)
Vascular β-adrenergic receptor system is dysfunctional after myocardial infarction (2001) (11)
Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2 (2019) (11)
Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy (2014) (11)
Functionally active targeting domainofthef-adrenergic receptor kinase: Aninhibitor ofGp'.mediated stimulation oftypeII adenylyl cyclase (1994) (10)
Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (2020) (10)
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function (2021) (10)
Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice (2019) (10)
Targeting GRK5 for Treating Chronic Degenerative Diseases (2021) (10)
Targeted (cid:1) -Adrenergic Receptor Kinase ( (cid:1) ARK1) Inhibition by Gene Transfer in Failing Human Hearts (2004) (10)
External support modulates G protein expression and receptor coupling in experimental vein grafts. (1999) (10)
GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells. (2017) (10)
GRK2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance Following Myocardial Ischemia (2011) (10)
Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. (2014) (10)
β-Arrestin 1 – Biased β 1-Adrenergic Receptor Signaling Regulates MicroRNA Processing (2014) (9)
Negative Regulation of VEGF Signaling in Human Coronary Artery Endothelial Cells by G Protein‐Coupled Receptor Kinase 5 (2009) (9)
β-arrestin2 Affects Cardiac Progenitor Cell Survival through Cell Mobility and Tube Formation in Severe Hypoxia (2018) (9)
Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1). (2005) (9)
Specific 2 AR Blocker ICI 118 , 551 Actively Decreases Contraction Through a Gi-Coupled Form of the 2 AR in Myocytes From Failing Human Heart (2002) (9)
A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure (2021) (9)
Regulated Overexpression of the A 1-Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function (2006) (9)
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction. (2001) (9)
Cardiac Fibroblast GRK 2 Deletion Enhances Contractility and Remodeling Following Ischemia / Reperfusion Injury (2016) (9)
G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. (2012) (8)
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. (1999) (8)
Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells. (2006) (8)
Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. (2013) (8)
Abstract 057: β-arrestin1-Biased β1-adrenergic Receptor Signaling Regulates MicroRNA Processing (2013) (8)
Reduction of lymphocyte G-protein coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure (2013) (8)
Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration (2018) (8)
A Gβγ inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts (2005) (8)
Aldosterone and Myocardial Pathology. (2019) (8)
c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. (2016) (8)
Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure. (2022) (8)
Dose dependent effects of cardiac β2 adrenoceptor gene therapy1 (2004) (8)
A 1 Adenosine Receptor Upregulation Accompanies Decreasing Myocardial Adenosine Levels in Mice With Left Ventricular Dysfunction failure, transgenic mice with left ventricular systolic Molecular Cardiology (2007) (8)
Potentiation of beta-adrenergic signaling by gene transfer. (1997) (8)
Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion. (2014) (7)
Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium (2013) (7)
Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure. (2009) (7)
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. (2002) (7)
L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta 2-adrenoceptor. (1999) (7)
Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging. (2000) (7)
Native-type DHP-sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac alpha 1 subunits expressed in Xenopus laevis oocytes and are regulated by alpha 2- and beta-subunits. (1992) (7)
Level of (cid:1) -Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure Heart Failure (2005) (7)
A pharmacokinetic analysis of molecular cardiac surgery with recirculation mediated delivery of βARKct gene therapy: developing a quantitative definition of the therapeutic window. (2011) (7)
Characterization of βARKct engineered extracellular vesicles and model specific cardioprotection. (2021) (6)
Comparative effects of urocortins and stresscopin on cardiac myocyte contractility. (2015) (6)
Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction. (2016) (6)
Abstract 2883: Retroinfusion-facilitated Inotropic AAV9-S100A1 Gene Therapy Restores Global Cardiac Function In A Clinically Relevant Pig Heart Failure Model (2008) (6)
Adiponectin Inhibits Oxidative/Nitrative Stress During Myocardial Ischemia and Reperfusion via PKA Signaling (2013) (6)
Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy* (2016) (6)
LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury (2021) (6)
1-Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 Reciprocal Down-Regulation Influences Cardiac Hypertrophic Response and Progression Toward Heart Failure : Protective Role of S 1 PR 1 Cardiac Gene Therapy (2013) (6)
beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery. (2004) (6)
Nuclear Effects of GRK5 on HDAC5-regulated Gene Transcription in Heart Failure (2011) (6)
Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia. (2013) (6)
Methods to improve cardiac gene therapy expression (2014) (6)
G Protein Signaling and Vein Graft Intimal Hyperplasia: Reduction of Intimal Hyperplasia in Vein Grafts by a Gbg Inhibitor (1998) (6)
Dose dependent effects of cardiac beta2 adrenoceptor gene therapy. (2004) (6)
Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells (2020) (6)
Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders (2022) (5)
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. (2000) (5)
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging (2020) (5)
Gbetagamma‐Mediated Signaling: New Therapeutic Target for Proliferative Vascular Disease (1999) (5)
Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy (2020) (5)
C1q/TNF-Related Protein-3, a Newly Identified Adipokine, Is a Novel Anti-Apoptotic, Pro-Angiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart (2012) (5)
MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis (2021) (5)
Metabolic Crosstalk between the Heart and Fat (2020) (5)
In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis. (2004) (5)
- Adrenergic Receptor Kinase Inhibitor β Transfer of a Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene (2001) (5)
Epidermal growth factor receptor-dependent maintenance of cardiac contractility. (2021) (5)
Adenoviral-mediated inhibition of G beta gamma signaling limits the hyperplastic response in experimental vein grafts. (1998) (5)
Catheter‐mediated delivery of adenoviral vectors expressing β‐adrenergic receptor kinase C‐terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries (2004) (5)
Abstract 5326: S100A1 Prevents Arrhythmogenic Diastolic Sarcoplasmic Reticulum Calcium Leak In Ventricular Cardiomyocytes (2008) (5)
GRK2-Mediated Desensitization of AdipoR1 in Failing Heart (2015) (5)
exhibit differences in ischemia / reperfusion injury: role of nitric oxide (2002) (4)
Potential future therapies for heart failure: gene transfer of beta-adrenergic signaling components. (1999) (4)
G Protein-Coupled Receptor Kinases and Hypertension (2006) (4)
Gene delivery approaches to heart failure treatment (2004) (4)
Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice. (2004) (4)
Cardiomyocyte GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms (2021) (4)
Calcium channel function and regulation in β1- and β2-adrenoceptor transgenic mice (2004) (4)
Gαq and its Aktions (2006) (4)
Systemic Blockade of ACVR 2 B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury (4)
A Gbetagamma inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts. (2005) (4)
A porcine model of intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts. (2003) (4)
Genetic manipulation of beta-adrenergic signalling in heart failure. (2001) (4)
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels (2022) (4)
Cardiomyocyte‐GSK‐3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms (2021) (3)
Myocardial overexpression of the cardiac b-adrenergic receptor kinase-1 inhibitor (BARKI) delay the development of cardiomyopathy induced by myocardial expression of monocyte chemo-tactic protein-1 (MCP-1) (2002) (3)
Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production (2021) (3)
Recent findings into the potential of gene therapy to reverse heart failure (2007) (3)
Gene interventions in the β-adrenergic system for treating heart failure (2003) (3)
Abstract 110: Tumor Necrosis Factor-alpha Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells via KLF4: Implications for Cerebral Aneurysm Pathology (2012) (3)
Abstract 371: Long-term Cardioselective S100A1 Gene Therapy Improves Cardiac Function in Heart Failure (2006) (3)
Gene transfer of β-adrenergic signaling components for heart failure (2002) (3)
Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging (2020) (3)
Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment. (2011) (3)
Galphaq and its Aktions. (2006) (3)
Abstract 112: Cigarette Smoke Directly Produces a Pro-inflammatory/matrix remodeling Phenotype in Cerebral Vascular Smooth Muscle Cells via KLF4: A Potential Mechanism for Cerebral Aneurysm Pathogenesis (2012) (3)
CALL FOR PAPERS Regulation of Cardiac Muscle Contraction S 100 A 1 : a novel inotropic regulator of cardiac performance . Transition from molecular physiology to pathophysiological relevance (2007) (3)
Abstract 308: CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways (2017) (3)
Intracoronary transgene delivery during cardiopulmonary bypass results in transmural cardiac-specific gene expression in neonatal pigs (2000) (3)
CARVEDILOL EXERTS POSITIVE INOTROPY IN CARDIOMYOCYTES BY UNIQUELY STIMULATING BETA-ARRESTIN2-DEPENDENT SERCA2A ACTIVITY VIA THE BETA1-ADRENERGIC RECEPTOR (2018) (3)
A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload. (2021) (3)
In Vivo Stimulation of α- and β-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles (2021) (3)
Reduction of Vascular Intimal-Medial Hyperplasia in Polytetrafluoroethylene Arteriovenous Grafts via Expression of an Inhibitor of G Protein Signaling (2005) (3)
Metabolomics, heart disease and aging (2021) (3)
Commentary: Advancing the Research Mission in an Academic Department: The Creation of a Center for Translational Medicine (2010) (3)
Selective Inhibition of Heterotrimeric GsSignaling (2002) (3)
Gene therapy for heart failure (2004) (2)
GRK2 in cardiovascular disease and its potential as a therapeutic target. (2022) (2)
Adrenergic Receptor Gene Delivery to the Endothelium Corrects Impaired Adrenergic (2002) (2)
Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure (2022) (2)
Gi/o signaling and its potential role in cardioprotection (2008) (2)
Abstract 14878: AAV6-betaARKct Cardiac Gene Therapy Rescues Failing Myocardium in a Clinically Relevant Large Animal Heart Failure Model (2010) (2)
Gene therapy for chronic heart failure (1997) (2)
Inhibition of Spontaneous b2-Adrenergic Activation Rescues b1-Adrenergic Contractile Response in Cardiomyocytes (2000) (2)
Basic Science and Experimental Study A Pharmacokinetic Analysis of Molecular Cardiac Surgery With Recirculation Mediated Delivery of bARKct Gene Therapy: Developing a Quantitative Definition of the Therapeutic Window (2011) (2)
Translational medicine in genetic familial diseases: from the autopsy room to the molecular bench and vice versa. (2005) (2)
Abstract 74: Nitrative Inactivation of Thioredoxin-1 and Its Role in Post-Ischemic Myocardial Apoptosis (2006) (2)
Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to injured heart. (2020) (2)
Potentiation of (cid:98) -Adrenergic Signaling by Adenoviral-mediated Gene Transfer in Adult Rabbit Ventricular Myocytes (1997) (2)
Eating Away at Heart Failure. (2015) (2)
Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and (cid:1) -Adrenergic Signaling Integrative Physiology (2006) (2)
A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload (2017) (2)
Is erythropoietin behind maladaptive anemic heart failure? (2009) (2)
A porcine Model of Intimal-Medial Hyperplasia in Polytetrafluoroethylene Arteriovenous Grafts (2003) (2)
Highlights of the 2009 Scientific Sessions of the Heart Failure Society of America, Boston, MA, September 13-16, 2009 (2010) (2)
Abstract 163: Inhibition of p38a Regulates SERCA2a Function (2013) (1)
Mitochondrial Dynamics in Neonatal and Adult Cardiomyocytes (2014) (1)
Circulation Research Compendium on Heart Failure (2013) (1)
Erythropoietin augments cardiomyocyte survival and left ventricular function after hypoxia (2003) (1)
Gene transfer of beta-adrenergic signaling components for heart failure. (2002) (1)
Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics (2022) (1)
GRK5‐mediated inhibitory phosphorylation is essential for inverse agonism at the cardiac mineralocorticoid receptor (2019) (1)
Cardioprotective effects of erythropoietin: a journey from the bedside back to the bench (2004) (1)
Abstract 75: Ischemic Heart Failure is Exacerbated in CD39-null Mice (2015) (1)
Endogenous Norepinephrine and Epinephrine-Adrenergic Receptor Kinase-1 in Mice Lacking β Enhanced Contractility and Decreased (1999) (1)
Abstract 16144: Death Associated Protein Kinase Mediates Myofibril Degeneration and Myocyte Apoptosis Induced by Beta-adrenergic Receptors (2016) (1)
Exosomes from G Coupled Receptor Kinase ( GRK 2 ) Knock-down Cells Suppress Fibroblast Apoptosis Potential Mechanism by Which GRK 2 Inhibition Provides Protection after Myocardial Infarction (2016) (1)
G i -Biased (cid:1) 2 AR Signaling Links GRK2 Upregulation to Heart Failure (2012) (1)
Late-Breaking Basic Science I 23633 The Transcription Factor Early B-cell Factor 1 is Critical for Proper Formation of the Cardiac Ventricular Conduction System (2016) (1)
Abstract 113: Klf5 and Ppara Expression is Increased at the Early Stage and Reduced at the Late Stage of Myocardial Ischemia/Reperfusion in Mice (2015) (1)
Abstract 14287: Ang II-induced Pathological Autophagy is Inhibited by IL-10 via Akt Dependent Inhibition of Beclin 1 in Mice Heart (2015) (1)
The e(cid:128)ect of Gi-protein inactivation on basal, and b 1 - and b 2 AR-stimulated contraction of myocytes from transgenic mice overexpressing the b 2 -adrenoceptor (1)
Abstract 577: S100A1 Decreases Calcium Spark Frequency and Alters their Spatial Characteristics in Ventricular Cardiomyocytes (2006) (1)
Abstract 37: The Positive Inotropic S100a1 Prevents Arrhythmogenic Sarcoplasmic Reticulum Ca2+ Leak And Ventricular Arrhythmias (2014) (1)
Gene interventions in the beta-adrenergic system for treating heart failure. (2003) (1)
Inhibition of G-protein coupled receptor kinase-2 protects from myocardial ischemia-reperfusion injury via an anti-apoptotic effect (2009) (1)
Ectonucleoside triphosphate diphosphohydrolase-1 (CD39) impacts TGF-β1 responses: Insights into cardiac fibrosis and function following myocardial infarction. (2022) (1)
Beta-Adrenergic gene therapy for cardiovascular disease (2000) (1)
[Gene therapy and benefits in modulating of system beta-adrenergic in cardiac insufficiency]. (2002) (1)
Abstract 19454: mmu_circ_008396 a Novel Circular RNA Involved in Myocardial Infarction (2016) (1)
Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. (2001) (1)
Abstract MP247: Mitochondrial Complex V Is Regulated By GRK2 In The Heart (2021) (1)
G Protein-coupled receptor kinase 2 impairs fatty acid metabolism in the failing heart through novel mechanisms (2018) (1)
Biased Agonism/Antagonism of β-Arrestin Activation by the Angiotensin II Type 1 Receptor: A Study of Sartans and Angiotensin II Analogs Using Aldosterone Turnover as a Readout (2010) (1)
Abstract 178: Calcineurin Inhibition Normalizes Beta-Adrenergic Responsiveness in the Spontaneously Hypertensive Rat (2007) (1)
Not All β-Receptors Appear the Same in Heart Failure: Emergence of β3-Agonists as a Therapeutic Option. (2022) (1)
Abstract 887: Cardiac-Specific Ablation of GRK2 Re-Defines its Roles in Heart Development and Beta-Adrenergic Signaling (2006) (1)
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension (2020) (1)
β ARKct gene-therapy improves β 2-adrenergic receptor-dependent neoangiogenesis following hindlimb ischemia (2015) (1)
The Path to Clinical Practice (2013) (1)
The yin and yang of increased β-adrenergic signaling: β1-adrenergic genetic polymorphism and protection against acute myocardial ischemic injury (2006) (1)
Adding another GRK to the fire of heart failure. (2020) (1)
Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner (2022) (1)
GRK2-S670A Mice reveal cardioprotection post ischemia-reperfusion (2016) (1)
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility (2013) (1)
Abstract 19138: S100A1 Genetically-targeted Therapy Reverses Dysfunction of Human Failing Myocardium (2010) (1)
Abstract 114: AdipoRon, the First Orally Active Adiponectin Receptor Activator, Attenuates Post-ischemic Myocardial Apoptosis via AMPK Activation and Oxidative Stress Reduction (2015) (1)
Abstract 3861: Over-expression of the A1-Adenosine Receptor Alters Cardiac Function by Inhibiting Production of Caveolin-3 (2009) (1)
Abstract 2733: Enhanced Cav1.2 Influx Induces Cardiac Conduction Disturbances and SR Ca2+ Overload to Induce Cardiac Arrhythmia but With Shortened QT and Action Potentials (2009) (1)
Adenoviral - mediated gene transfer of a β - adrenergic receptor kinase inhibitor attenuates right ventricular dilatation after pulmonary artery banding (2000) (1)
G bg -dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy* (2000) (1)
Abstract 396: GRK5-mediated Exacerbation of Ischemic Heart Failure Involves Cardiac Immune-Inflammatory Responses (2017) (1)
Abstract 646: Myocardial Ischemia/Reperfusion Impairs Adipocyte Endocrine Function via Exosome-Mediated Endoplasmic Reticulum Dysfunction (2019) (1)
The yin and yang of increased beta-adrenergic signaling: beta1-adrenergic genetic polymorphism and protection against acute myocardial ischemic injury. (2006) (1)
Cardiac gene delivery using DNA-adenoviral constructs. (2005) (1)
Abstract 10263: Biased Agonism/Antagonism of Sartans and Angiotensin II Analogs for Angiotensin II Type 1 Receptor-Induced, {beta}-Arrestin--Dependent Aldosterone Production in Heart Failure (2010) (1)
- βARK: β-Adrenergic receptor kinases (vertebrates) (1995) (1)
Science Signaling Podcast for 22 March 2016: Preventing heart failure with GRK2 (2016) (0)
β 1 -Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 (S1PR1) Reciprocal Downregulation Influences Cardiac Hypertrophic Response and Progression to Heart Failure Protective Role of S1PR1 Cardiac Gene Therapy Heart Failure (2013) (0)
β2‐Adrenergic Receptor Expression on Hematopoietic Cells is Critical for Survival Following Myocardial Infarction (2015) (0)
Abstract 108: Transcriptional and Epigenetic Regulation of MCP1 by Tumor Necrosis Factor-a and Cigarette Smoke: Key Mediators in Aneurysm Formation (2013) (0)
Abstract 51: Aldosterone Induces Cardiac Deleterious Effects Through A Grk2 And Grk5 Dependent Pathway (2014) (0)
08 β2-AR-mediated DNA synthesis is dependent on EGFR and ERK MAP kinases in adult rat cardiac fibroblasts (2002) (0)
Domain‐Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure (2017) (0)
Abstract 13552: Clinical Relevance of Endogenous Tissue-plasminogen Activator in Patients With Aortic Valve Sclerosis (2020) (0)
βARKct gene delivery reverses atrophic gene regulation and enhances β-adrenergic response in the unloaded heart (2012) (0)
Podoplanin neutralization improves cardiac remodeling and function after myocardial infarction (2019) (0)
β‐Arrestin‐Biased β2‐Adrenergic Receptor Signaling Provides Cardioprotection in Ischemia/Reperfusion Injury (2017) (0)
Abstract 630: Effects of Chronic Exercise on Restoring Age-impaired VEGF Upregulation and Angiogenetic Responses to Hindlimb Ischemia (2006) (0)
Abstract MP122: Effects of Cardiac Beta3-Adrenoceptors on the Inhibition of G Protein-coupled Receptor Kinase 2 via S-nitrosylation (2020) (0)
Abstract 954: Novel Mechanism of Adiponectin Cardioprotection Following Myocardial Ischemic/Reperfusion (2006) (0)
TRPM2ChannelsProtectagainstCardiacIschemia-Reperfusion InjuryIA *□S (2014) (0)
TRUSS Training in Reducing Uncertainty in Structural Safety: D3.11: WP3 - Structured Training (2019) (0)
363 Apoptosis Occurs in Late Stages of Unloading Related Ventricular Remodeling (2012) (0)
Abstract 1609: GRK2 Overexpression is Deleterious in Myocardial Ischemia-Reperfusion Injury - Inhibition via {beta}ARKct Mediates Cardioprotection (2008) (0)
Correction for Martini et al., Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008) (0)
Abstract 1576: A Novel Nuclear Function for GRK5 and Its Potential Role in the Cardiac Hypertrophic Response (2006) (0)
Abstract 2696: Phospholemman and B-Adrenergic Stimulation in Intact Hearts (2009) (0)
Abstract 516: GRK5 Regulates Cardiac Fibroblast Differentiation and Fibrosis (2019) (0)
Vascular b -adrenergic receptor system is dysfunctional after myocardial infarction (2001) (0)
SUPPLEMENTAL MATERIAL Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V 1 A Receptor Causes Reversible Left Ventricular Dysfunction Through G q-Mediated Cell Signaling (2011) (0)
Differential regulation of rat myocardial genes in the unloaded heart: a time course study (2010) (0)
Abstract 16796: β2-Adrenergic Receptor Expression on Hematopoietic Cells is Critical for Survival Following Myocardial Infarction (2014) (0)
Abstract 19301: Lymphocyte G-Protein Coupled Receptor Kinase-2 (grk2) Levels Predict Cardiac Mortality in Patients With Advanced Heart Failure. (2010) (0)
Determines the Outcome to Cardiac Ischemic Injury Convergence of G Protein-Coupled Receptor and S-Nitrosylation Signaling ` (2013) (0)
Differential temporal regulation of cardiac cytokine expression in response to chronic β‐adrenergic receptor stimulation (652.4) (2014) (0)
Abstract 606: Stimulation of Cardiomyocyte a- and b-Adrenoceptors Uniquely Regulates Exosome Generation and miRNA Content (2019) (0)
Abstract 3390: G- Protein Coupled Receptor Kinase-2 (GRK2) Induces Insulin Resistance in Cardiac Myocytes (2009) (0)
β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure (2023) (0)
Abstract 3: Il-10 Regulated Mir-375 Enhances Endothelial Progenitor Cell Mediated Myocardial Repair And Survival After Myocardial Infarction. (2014) (0)
Abstract 9485: Cardiac G Protein-Coupled Receptor Kinase 2 Knockdown Decreases Ischemia/Reperfusion-Induced Injury and Improves Cardiac Function through Anti-Apoptotic Mechanisms (2010) (0)
Abstract 169: Elucidating the role of GRK5 in Physiological Hypertrophy (2014) (0)
Abstract 339: Long-term AAV6-{beta}ARKct Myocardial Gene Therapy Improves Cardiac Function Via Restoration Of {beta}-Adrenergic Receptor Signaling And Neurohormonal Status Of The Failing Heart (2008) (0)
Abstract 208: Mitochondrial-targeted Grk2 Increases Superoxide Formation And Impairs Cardiomyocyte Respiratory Reserve Capacity (2014) (0)
Abstract 3637: Expression of the NOS3 Activator S100A1 is Negatively Regulated by a NO-dependent Posttranslational Mechanism in Cardiac Endothelial Cells (2008) (0)
Abstract 1623: Cardiac Expression of an Intracellular G{alpha}q Inhibitor Preserves Cardiac Function and Reduces Apoptosis Following Ischemia and Reperfusion Injury in Mice (2006) (0)
Adrenergic Signaling and Function β Hybrid Transgenic Mice Restores Normal-Adrenergic Receptor Kinase Activity in β In Vivo Inhibition of Elevated Myocardial (1999) (0)
Abstract 16831: β-Arrestin-Biased β2-Adrenergic Receptor Activation Confers Cardioprotection in Ischemia/Reperfusion Injury (2017) (0)
Abstract 372: Regulation of Nox1 and Nox2 by Cigarette Smoke in Cerebral Vascular Smooth Muscle Cells: A Role of Oxidative Stress in Cerebral Aneurysm Formation (2012) (0)
Darbepoetin Alpha and Insulin-Like Growth Factor-1 Protect the Rat Myocardium Against Myocardial Infarction and Lead To Enhance Angiogenesis (2007) (0)
Abstract 3506: Lymphotoxin-a is a Novel Suppressor of Adiponectin Expression and Contributes to Hypoadiponectinemia in Myocardial Ischemic/Reperfused Mice (2009) (0)
Abstract 362: Restoring Diabetes-induced Autophagic Flux Arrestment in Ischemic/Reperfused Heart by Adiponectin Receptor Activation Involves Both AMPK-Dependent and AMPK-Independent Signaling (2017) (0)
Abstract P033: β-Adrenergic Signaling Mediates Cardiac Stem Cell Survival (2011) (0)
Abstract 258: Elucidating Sex Differences in Stress-related Atrial Remodeling and AF Risk in a Mouse Model of Atrial Dysfunction (2019) (0)
In vivo pulmonary artery adenoviral gene transfer of nitric oxide synthase enhances pulmonary nitric oxide production (1997) (0)
Adrenal-Specific G Protein-Coupled Receptor Kinase (GRK)-2 Deficiency Reduces Circulating Catecholamine Levels and Improves Cardiac Function after Myocardial Infarction (2013) (0)
Abstract 312: Cardiomyocyte-secreted Signaling Factors Modulate Adipocyte Differentiation And Function (2018) (0)
Erratum: Antisense oligonucleotide to proto-oncogene c-myb inhibits the formation of intimal hyperplasia in experimental vein grafts (Journal of Vascular Surgery (1997) 25 (433-63)) (1997) (0)
Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (2020) (0)
Abstract 340: Myocyte-borne Bdnf is Essential to Limit Post-ischemic Cardiac Injury and Dysfunction (2020) (0)
Abstract 475: Beta-adrenoceptor Stimulation Uniquely Regulates Exosome Micro-rna Content Secreted From Cardiomyocytes in vitro and Those Found in vivo Circulating in Blood (2020) (0)
Abstract 075: Novel Role for GRK2 in Cardiac Hypertrophy and Heart Failure (2013) (0)
Abstract P346: Regulation of GRK5 in Myocytes Is Mediated by Nuclear Transcription Factor [ê]B: A New Clue in Heart Disease (2011) (0)
S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models (2023) (0)
Abstract 578: β-arrestin-Biased β2-Adrenergic Receptor Signaling Enhances Cardiomyocyte Contractility via ROCK-Dependent Signaling (2018) (0)
Abstract 298: Pluripotent Stem Cell Microrna-294 as a Mediator of Cardiac Proliferative Response After Myocardial Injury (2016) (0)
Cardiac hypertrophy is associated with increased β-adrenergic receptor kinase (βARK) (1997) (0)
Abstract 109: G Protein-coupled Receptor Kinase 2 Impairs Fatty Acid Metabolism in the Failing Heart Through Novel Mechanisms (2018) (0)
Abstract EC103: A Novel Nuclear Role For REDD1 In Cardiac Insulin Sensitivity And Resistance (2022) (0)
2009 Thomas W. Smith Memorial Lecture--GRK2 Inhibition as a Novel Therapeutic Target in Heart Failure (2009) (0)
Abstract 125: Role for β-Arrestins in Cardiac Inflammation and Regenerative Repair (2014) (0)
GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12 (2021) (0)
Adenoviral gi-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae (2002) (0)
Abstract 372: {beta}1-adrenergic Receptor Blockade and Cardiac {beta}2 Overexpression Stimulates Angiogenesis in the Failing Heart (2006) (0)
Abstract 16932: Embryonic Stem Cell Derived Exosomes Revive Endogenous Repair Mechanisms in Failing Hearts (2014) (0)
Abstract 129: Embryonic Stem Cell Derived Exosomes Revive Endogenous Repair Mechanisms In Failing Heart (2014) (0)
Abstract 557: Exosome Biogenesis/Uptake Mediates Cardioprotection by Globular Adiponectin but Not High Molecular Weight Adiponectin (2018) (0)
Abstract 17154: G Protein-Coupled Receptor Kinase-2 Regulates Alpha2a-Adrenergic Receptor Function and Catecholamine Release in Human Adrenal Chromaffin Cells (2012) (0)
Abstract 13228: Apoptosis Occurs in Late Stages of Unloading Related Ventricular Remodeling (2011) (0)
G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation (2016) (0)
Adrenergic Receptor Signaling Components in Gene Therapy (2006) (0)
Exercise Training Increases Beta Adrenergic Responsiveness In Hypertension: 2176 9:45 AM - 10:00 AM (2005) (0)
Abstract 12746: Impaired Autophagic Flux in Ischemic/Reperfused Diabetic Heart and Its Reversal by a Novel Orally Active Adiponectin Receptor Agonist via AMPK-Mediated Autophagosome Formation and AMPK-Independent Autophagosome Clearance (2015) (0)
08 Transgenic mice with vascular GRK5 over-expression have elevated blood pressure which segregates by sex (2002) (0)
Metoprolol prevents post‐ischemic myocardial decompensation via β3AR‐dependent protective Sphingosine‐1 phosphate signaling (2017) (0)
Abstract 24047: G Protein-coupled Receptor Kinase 2 Negatively Regulates Fatty Acid Utilization and Mitochondrial Bioenergetics (2017) (0)
Abstract 1250: Loss Of G Protein-coupled Receptor Kinase 2 (grk2) In Cardiac Myocytes Protects Against Structural Heart Disease (2007) (0)
Abstract 20107: The Matricellular Protein CCN2/CTGF Attenuates Ventricular Remodeling by Enhancing Scar Healing after Myocardial Infarction (2014) (0)
Abstract 841: Loss of S-nitrosylation of G Protein-Coupled Receptor Kinase 2 Leads to Cardiovascular Dysfunction With Aging (2019) (0)
657 Dual S100A1/BARKct adenoviral gene transfer in ventricular cardiomyocytes (2007) (0)
Abstract 366: The Role of Mitochondrial Calcium Uniporter Complex in Cardiac Contractility and Function (2018) (0)
Myocytes From Failing Human Heart (2002) (0)
AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin Molecular Cardiology (2009) (0)
Heart Failure Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction (2012) (0)
Abstract 580: A β-arrestin-Biased β2-Adrenergic Receptor-Specific Pepducin Confers Cardioprotection (2018) (0)
Abstract P1036: Role Of Mitochondrial Ribosomal Protein L7/l12 (mrpl12) In Diabetic Ischemic Heart Disease (2022) (0)
Abstract 8556: Inhibition of Grk2 Augments Cardiac Beta2-Adrenergic Receptor-Dependent Contractility via Prevention of Receptor Interaction with Phosphodiesterase Type 4d (2011) (0)
Abstract 13141: Cellular Microrna 449b Upregulation Sensitizes Ischemia/reperfusion Injury via Inhibition of Nrf-1, Increasing Ros Production and Apoptosis in the Diabetic Heart (2015) (0)
adrenergic stimulation signaling and enhance cardiac responsiveness to-adrenergic receptor β age-dependent impairment of-blocker treatment ameliorate β Exercise training and (2007) (0)
Abstract 318: Adrenal G-Protein Coupled Receptor Kinase (GRK) 2 Activity is a Potential novel Bio-Marker of Sympathetic Outflow in Chronic Heart Failure (2006) (0)
Abstract 17341: The Matricellular Protein CCN2/CTGF Enhances Scar Healing After Myocardial Infarction and Inhibits TGFβ-Induced Myofibroblast Differentiation Limiting Myocardial Fibrosis (2013) (0)
Abstract 5570: {beta}-2 Adrenergic Receptors Overexpression Promotes Angiogenesis in the Failing Myocardium through Activation of Vascular Endothelial Growth Factor/Akt Transduction Pathway (2008) (0)
Abstract 19409: β2-Adrenergic Receptor Regulation of Innate Immune Responses Following Acute Myocardial Injury (2015) (0)
- Adrenergic Receptor Stimulation and Blockade β Expression by Coupled Receptor Kinase − Reciprocal In Vivo Regulation of Myocardial G Protein (1998) (0)
Abstract 9478: GRK2-Mediated Phosphorylative Desensitization of AdipoR1 in the Failing Heart (2014) (0)
Excess Ca2+ Influx through the L-Type Ca2+ Channel Exacerbates Ischemia-Induced Cardiac Damage (2007) (0)
G-Protein Coupled Receptor Kinase Expression in Lymphocytes – A Novel Biomarker of Left Ventricular Systolic Function in Heart Failure Patients (2009) (0)
Abstract 5118: Cardiac β1-Adrenergic Receptor Blockade Promotes Angiogenesis in the Post-Ischemic Failing Heart via Activation of VEGF- and Akt-dependent Signalling Pathways (2009) (0)
GRK2 downstream aldosterone and mineralocorticoid receptor system induces cardiac insulin-resistance and β-adrenergic dysfunction (2020) (0)
Abstract 70: Upregulation of Myeloperoxidase as a Novel Mechanism for Increased Myocardial Ischemic/Reperfusion Injury in Hypercholesterolemia (2006) (0)
The Pharmacokinetics of Molecular Cardiac Surgery with Recirculating Delivery (MCARD™) Results in Robust Cardiac-Specific βARKct Gene Delivery to Ovine Myocardium (2010) (0)
Identification of Role of Mitochondrial Chloride Intracellular Channel (CLIC) Protein, CLIC4 and CLIC5 in Cardioprotection from IR Injury via Probably Modulating the Opening of MPTP Pore (2020) (0)
1-Adrenergic Stimulation α-but not β Hypertrophy : Regulation by-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial (1999) (0)
Abstract 341: Nucleotide Triphosphate Diphosphohydrolase-1 (NTPDase1) Overexpression Improves Post-Myocardial Infarction Recovery (2013) (0)
Mitochondrial Calcium Entry Induces Mitochondrial Reactive Oxygen Species Production by ATP Synthase‐uncoupled, But Proton Leak‐coupled Mechanism – A New System of How Atherogenic Stimuli Activate Aortic Endothelial Cells without Compromising Endothelial Cell Survival (2016) (0)
Abstract 9571: Activation of LXR{alpha} but Not LXR{beta} Protects the Heart from Ischemia/Reperfusion Injury (2012) (0)
Correction to "Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine". (2019) (0)
Abstract 13730: Cardiac-Specific GRK2 Ablation Can Promote Cardiac Myocyte Regeneration after Ischemia/Reperfusion Injury (2011) (0)
Abstract 16734: Il-10-Inhibit Pressure Overload-Induced Proliferation and Differentiation of Fibroblast Progenitor Cells and Thus Improve Cardiac Function (2014) (0)
Abstract 24071: A Peptide Of The Amino-terminus Of Grk2 Induces Hypertrophy And Yet Elicits Cardioprotection After Pressure Overload. (2017) (0)
Abstract 262: GRK5 is a Novel Regulator of Fibroblast Activation (2018) (0)
Modification of in vivo cardiac performance by intracoronary gene transfer of beta-adrenergic receptor signaling components. (2003) (0)
Walter J. Koch: two decades, one mission. (2015) (0)
Abstract 9905: Nitrative Modification of Caveolin-3 and Subsequent Dissociation From AdipoR1 Occurs in Failing Heart and Contributes to Adiponectin Resistance (2013) (0)
Abstract 288: Circular RNA CircFNDC3b Modulates Cardiac Repair After Myocardial Infarction via FUS-1/VEGF-A Axis (2018) (0)
Abstract 11678: Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation (2014) (0)
In Vivo Inhibition of Elevated Myocardial (cid:98) -Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal (cid:98) -Adrenergic Signaling and Function (1999) (0)
Abstract 074: GRK5 Increases Cardiac NFAT Transcriptional Activity (2013) (0)
Science Signaling Podcast: 29 October 2013 (2013) (0)
Adiponectin improves vascular endothelial dysfunction through caveolin-1 mediated nuclear translocation and HDAC inhibition (2020) (0)
Abstract 347: S100A1 is Critical for Neoangiogenesis Following Hind-Limb Ischemia (2006) (0)
Uncovering a role of β3-adrenoceptors in control of bladder size (2021) (0)
Abstract 17473: GRK2 in the Mitochondria: Uncovering Novel Mechanisms in Heart Failure (2020) (0)
Abstract 353: Genetic GRK2 Abolishment Enhances Excitation-Contraction Coupling and Inhibits Adverse Ca2+-Handling Remodeling after Myocardial Infarction (2008) (0)
Abstract 446: Synergistic Rescue of Failing Ventricular Cardiomyocytes through Dual S100A1/BARKct Adenoviral Gene Transfer (2006) (0)
Abstract 374: Epigenetic Mechanisms Regulate TNF-α-Induced Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Biology (2012) (0)
Cardiac GRK2 Ablation Induces a Novel Ca Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction (2012) (0)
Abstract 1378: Cardiac-Specific Deletion of GRK2 using Cre-LoxP-Technology (2006) (0)
Abstract 1322: Exercise Stimulates Angiogenesis and Improves {beta}-Adrenergic Receptor Signaling in the Failing Heart (2006) (0)
Persistent Increases In Ca2+ Influx Through Cav1.2 (ICaL)Induce Cardiac Conduction Disturbances And Sarcoplasmic Reticulum Ca2+ Overload To Induce Cardiac Arrhythmia And Sudden Death (2009) (0)
Specific &bgr;2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the &bgr;2AR in Myocytes From Failing Human Heart (2002) (0)
Abstract 195: Increases in Ca2+Influx through the L-type Ca2+Channel Induces Pathological Cardiomyocyte Hypertrophy (2007) (0)
Abstract 19709: Increasing Ca2+ Influx After Myocardial Infarction Improves Myocyte Contractility but Depresses Cardiac Pump Function by Increasing Myocyte Death (2010) (0)
Abstract 1574: Lymphocyte GRK2 as a Novel Biological Marker of Alzheimer's Disease (2006) (0)
Abstract 13024: GRK5 Regulates Cardiac Fibroblast Differentiation and Fibrosis (2019) (0)
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection (2022) (0)
Abstract 333: TNF Receptor Modulation of Progenitor Cells and Exosomes for Myocardial Repair (2018) (0)
Abstract 3274: Differential Role of TNF Receptor 1 and Receptor 2 in Myocardium Ischemic Injury: Potential Role of Adiponectin Expression (2009) (0)
Abstract 70: Domain-Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure (2014) (0)
Methods of Sequestering βγ in the Intact Cell (2020) (0)
Genetic Deletion of β-Arrestin-1 Improves Function of the Infarcted Heart by Reducing Cardiac β-Adrenergic Receptor Desensitization and Cardiotoxic Neurohormonal Overstimulation (2009) (0)
Thomas L. Force, MD: 1951-2020: A Brilliant Physician-Scientist Gone Too Soon. (2021) (0)
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. (1998) (0)
Association Animal Models of Heart Failure : A Scientific Statement From the American Heart (2012) (0)
Abstract 277: Neonatal Cardiomyocyte-Released Signaling Protein Reduces Adipocyte Differentiation (2019) (0)
Abstract 1057: Specific Targeting of Gi Signaling in Normal and Dysfunctional Myocardium (2007) (0)
A novel mitochondrial associated membrane chloride channel, clic4, in cardio-protection from ischemia-reperfusion injury (2022) (0)
CardioprotectionCells Contributes to Ischemic Activation of Hypoxia Response in (2014) (0)
Abstract 815: Adrenal Beta-arrestin 1 Mediates Angiotensin II-induced Aldosterone Production In Vitro And In Vivo (2007) (0)
Kinase 5 ( GRK 5 ) Expression Cardiac G Protein-coupled Receptor Signaling Pathway in Regulation of B ) κ B ( NF-κ Involvement of Nuclear Factor Gene Regulation : (2012) (0)
Abstract 13813: Prior β-Blocker Treatment Dampens Immune Cell Responses Following Myocardial Infarction (2016) (0)
Abstract 15111: Ctrp9 Enhances the Proliferation, Survival, and Paracrine Effect of Engrafted Adipose-Derived Mesenchymal Stem Cells (adsc) in Post-mi Mouse Heart (2016) (0)
Enhanced insulin‐responsive AS160 elicits cardioprotection during metabolic stress (2021) (0)
Abstract 295: Enhanced Cardiac Function And Lower Circulating Aldosterone Levels In βArrestin1 Knockout Mice During Post-myocardial Infarction Heart Failure Progression (2013) (0)
134 Time-dependent loss of beta 4-adrenoceptor responses in beta 2-overexpressing rat myocytes is reversed by pertussin toxin treatment (2003) (0)
Abstract 318: MicroRNA Regulation of G Protein-Coupled Receptor Kinase 2 After Cardiac Injury (2018) (0)
Abstract 301: Initial Increase of Klf5 and Ppara Expression After Myocardial Ischemia/Reperfusion in Mice Appears to be Critical for Survival (2016) (0)
Decision letter: The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy (2018) (0)
2 Gene Therapy Approaches to Cardiovascular Disease (2004) (0)
Abstract 098: Blocking Cardiac Gq-Receptor Coupling Prevents Adverse Remodeling and Preserves Myocardial Function after Ischemic Injury in Mice and Promotes Repair via Cardiac Regeneration (2013) (0)
Abstract 330: Systemic Blocking Exosome Formation/Release Improves Ischemic Hindlimb Repair in Diabetic db/db Mice (2018) (0)
Abstract 311: In vitro Regulation of G-protein Coupled Receptor Kinase 5 (GRK5) Induced Cardiac Hypertrophy by a Novel Interaction With the Phosphatase PHLPP2 (2018) (0)
Abstract 16220: Negative Regulation of Mir-375 by Interleukin-10 Enhances Endothelial Progenitor Cell Mediated Myocardial Repair and Function After Myocardial Infarction (2014) (0)
Abstract 043: Regulation of cardiac excitability by non-canonical Sonic Hedgehog signaling. (2013) (0)
Death‐associated protein kinase mediates myofibril degeneration and myocyte apoptosis induced by beta‐adrenergic receptors (404.3) (2014) (0)
Abstract 9951: Cardiac GRK2 Inhibition via ARKct Augments 2-adrenergic Receptor-dependent Contractility and Survival Post-Myocardial Infarction (2012) (0)
Abstract 56: Candesartan And Valsartan, Contrary To Irbesartan, Are Potent Biased Antagonists Of Adrenal (beta)arrestin-dependent, Angiotensin II Type 1 Receptor-induced Aldosterone Production And Improve Cardiac Function Post-myocardial Infarction (2014) (0)
GRK5 contributes to impaired cardiac function and immune cell recruitment in post- ischemic heart failure Short title: Myocardial GRK5 in post-ischemic heart failure (2021) (0)
Improvement of cardiomyocyte performance in a pacing model of heart failure via adenoviral-mediated S100A1 gene delivery (2003) (0)
Gene Therapy Strategies to Augment Contractile Function in Heart Failure (2001) (0)
Abstract 52: Temporal Regulation Of Cardiac Cytokine Expression in Response to Chronic β-Adrenergic Receptor Stimulation (2014) (0)
phosphorylation : role of the F 0 / F 1-ATPase Ca 2 + activation of heart mitochondrial oxidative (2000) (0)
G Protein-Coupled Receptors: β-Adrenoceptors in cardiovascular and respiratory diseases (2010) (0)
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair. (2023) (0)
Identifying Sex‐dependent Markers of Heart Failure and Atrial Myopathy (2021) (0)
CLIC4 and CLIC5, Mitochondrial Chloride Channel Proteins Mediate Cardioprotection Against Ischemia Reperfusion Injury (2018) (0)
Abstract 124: Chronic Beta-Adrenergic Stimulation Prevents Protective Insulin-Induced Increases in Cardiomyocyte Respiratory Capacity (2017) (0)
Abstract P3053: Mitochondrial Calcium Accumulation Drives The Progression Of Non-ischemic Heart Failure: Integrated Lessons From Genetic Mouse Models (2022) (0)
A Novel Nuclear Function for GRK5 and Its Potential Role in the Hypertrophic Response (2007) (0)
Abstract 16409: Potential Role for βArrestins in Cardiac Regeneration (2012) (0)
Research August 30 , 2013 Safe and Efficient Viral Vector Systems for Clinical Cardiac Gene Delivery (2013) (0)
G-Protein Receptor Kinase-5 Polymorphism Influences Therapeutic Efficacy of β-Blockers in Heart Failure (2006) (0)
Adrenal-Targeted GRK2 Gene Deletion Ameliorates Sympathetic Overstimulation and Improves Function of the Failing Heart (2008) (0)
Abstract 3673: A Novel Mechanism for Akt2 in Ischemic Myocardial Repair: Limiting Macrophage Density (2009) (0)
Abstract 11301: AdipoRon, the First Orally Active Adiponectin Receptor Activator, Attenuates Myocardial Ischemia/Reperfusion Injury by AMPK-Mediated Autophagy and AMPK-Independent Anti-Apoptosis (2014) (0)
Abstract 327: Inhibition of Cardiac Myocyte Gq Signaling in High Blood Pressure Improves Cardiac Remodeling and Beta-Adrenergic Receptor Response (2008) (0)
Vascular Endothelial Growth Factor Blockade Prevents the Beneficial Effects of - Blocker Therapy on Cardiac Function, Angiogenesis and Remodeling in Heart Failure Rengo et al: -Blocker Induces Angiogenesis via VEGF/Akt/eNOS Pathway (2013) (0)
Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals (2023) (0)
GRK5‐Dependent p53 Activity Controls Basal Cardiac Function and Survival (2021) (0)
Abstract 16335: S100A1 Prevents SR Ca2+ Leak and Protects Against Arrhythmias in Ventricular Cardiomyocytes (2012) (0)
Results Novel Method of MI or I / R Is More Efficient Than Classic Method With Shortened Recovery Time and Less Inflammation (2010) (0)
Abstract 110: Adiponectin Inhibits TNF-a-Induced Vascular Inflammatory Response via Caveolin-Mediated Ceramidase Recruitment and Activation (2013) (0)
β2‐Adrenergic Receptors Regulate Innate Immune Responses Through β‐Arrestin Dependent Pathways (2016) (0)
Regulation of Myocardial bARK1 Expression in Catecholamine-Induced Cardiac Hypertrophy in Transgenic Mice Overexpressing a1B-Adrenergic Receptors (2016) (0)
Abstract 9763: Cardiac Beta-arrestin2 Promotes Contractility by Enhancing SERCA2a SUMOylation and Activity (2015) (0)
Abstract P339: The Mechanistic Relationship Between GRK2 and eNOS During Cardiac Ischemia/Reperfusion Injury (2011) (0)
Abstract 254: MicroRNA Regulation of G Protein-Coupled Receptor Kinase 2 After Cardiac Injury (2017) (0)
Commentary on Article by White and Milano Entitled “Gene Therapy in Cardiovascular Disease: State of the Art” (2003) (0)
Identification of a CTRP9 Fragment Capable of Enhancing Bone Marrow Mesenchymal Stem Cell Cardioprotection via Cardioreparative Exosome Production Promotion (2020) (0)
Myocardial gene transfer of β-adrenergic signaling components as potential therapy for heart failure (1998) (0)
Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice (1998) (0)
Abstract 1577: Cardiac Specific Inhibition of Gq Signaling Improves Cardiac Function by Improving Extracellular Remodeling Following Chronic Hypertension (2006) (0)
Abstract P426: Inactivating Grk5 Impairs Basal Cardiac Function And Survival Via P53 Modulation (2021) (0)
Abstract 16325: Robust MCARDTM-mediated {beta}ARKct Expression Results in Acute Reverse Remodeling in Ovine Ischemic Cardiomyopathy (2010) (0)
STIMulating a new treatment for sepsis (2013) (0)
Abstract 917: Actively Blocking Nuclear Localization of G Protein-Couple Receptor 5 Blunts Hypertrophy and Heart Failure After TAC (2019) (0)
inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts (2005) (0)
Abstract 15: Limiting GRK2 in the Ischemic Heart can Promote Cardiac Regeneration (2014) (0)
Abstract 106: G Protein-coupled Receptor Kinase 2 Associates With Mitochondrial Proteins and Negatively Alters Mitochondrial Respiration After Myocardial Infarction (2016) (0)
CARDIAC-TARGETED AAV-S100A1 HEART FAILURE GENE THERAPY: TRANSLATION OF A NOVEL MOLECULAR TARGET TOWARDS CLINICAL CARE (2011) (0)
189 Extracellular S100A1 protein modulates cardiac matrix gene expression through activation of the MAPK - NF-kappaB signalling pathway (2007) (0)
Abstract P375: Gender-based Cardio-protective Functional Dimorphism Of Bone Marrow Endothelial Progenitor Cells And Their Exosomes: Estrogen-independent Epigenetic Mechanisms (2021) (0)
L-type calcium current and contractility in ventricular myocytes from mice 1 overexpressing the cardiac b -adrenoceptor 2 (1999) (0)
Abstract 19097: Enhanced Beta-Adrenergic Signaling Reverses Atrophic Gene Regulation in the Unloaded Heart (2010) (0)
Abstract 18468: ERK-Mediated Phosphorylation of GRK2 at Ser 670 is Essential for its Hsp90-dependent, Stress-Activated Mitochondrial Localization (2010) (0)
[Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]. (2009) (0)
Abstract P006: A Potential Role for β-Arrestins in Cardiac Regeneration (2011) (0)
Abstract 548: Exercise and {beta}-Adrenergic Receptor (AR) Blockade Restore Age-dependent Impairment of {beta}-AR Signaling and Myocardial Inotropic Reserve (2006) (0)
Abstract 290: Cardiac Myocyte Gq Signaling Decreases Cardiac Function During Chronic High Blood Pressure Through Cardiac Remodeling (2007) (0)
Abstract 227: The Effect of PHLPP2 Removal on Cardiomyocyte Hypertrophy (2015) (0)
Abstract 3880: GRK2 Inhibition Prevents Development Of Cardiac Insulin Resistance And Impaired Glucose Uptake In Post Ischemic Heart Failure (2008) (0)
Abstract 693: Rgs Homology Domain Of GRK5 Regulates Postischemic Neoangiogenesis By Inhibiting NFkB Trascriptional Activity (2007) (0)
Deletion Of P 53 In Endothelial Cells Prevents Cardiac Fibrosis And Heart Failure Induced By Pressure Overload In Mice Via Enhanced Angiogenesis (2013) (0)
Integrative Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction (2012) (0)
Transgenic Mouse Models of Cardiovascular Function and Disease (2004) (0)
GRK2 Expression in Lymphocytes of Human Patients with Heart Failure-A New Biomarker (2006) (0)
Heart failure gene therapy: closer to reality. Professor Walter Koch speaks to Christine Forder, commissioning editor. (2009) (0)
G¯°-Mediated Signaling: New Therapeutic Target for Proliferative Vascular Disease (1999) (0)
Basic Science and Experimental Study Induced Overexpression of Na D /Ca 2D Exchanger Does Not Aggravate Myocardial Dysfunction Induced by Transverse Aortic Constriction (2012) (0)
Abstract TMP26: Binding of KLF4 and HDAC2 to The Promoter Region of SM22alpha Mediates Phenotypic Modulation In vitro and In vivo: Implications in Cerebral Aneurysm Formation (2013) (0)
Differential expression of G-protein coupled receptor kinases after mechanical unloading in the failing human heart (2003) (0)
Abstract 11333: Muscle Specific MicroRNA-499-5p Impairs Angiogenesis in Ischemic Hindlimb of Diabetic Micehindlimb of Diabetic Mice (2021) (0)
Abstract P2104: Adeno-associated Virus Serotype 5 Is A Suitable Vector For S100a1-based Gene Therapy Of Post-ischemic Chronic Cardiac Dysfunction (2022) (0)
Nuclear Translocation of GRK5 Following Hypertrophic Stimuli Is a Calmodulin-Dependent Process (2010) (0)
Abstract 16333: S100A1 Deficiency Impairs Post-Ischemic Angiogenesis via Compromised Proangiogenic Endothelial Cell Function and Nitric Oxide Synthase Regulation (2012) (0)
Abstract 47: Loss of the Cardio Protection Inferred by S-nitrosylation of GRK2 At Cysteine 340 Leads to Decreased Cardiac Performance and a Hypertensive Phenotype With Aging (2015) (0)
IS106 Genetic Manipulation of Beta-adrenergic Signaling in the Failing Heart (2000) (0)
Abstract 1605: T-Type Calcium Current Activates Pro-Survival Signaling Pathways after Myocardial Infarction (2008) (0)
Mitochondrial Fusion Dynamics in the Heart (2015) (0)
Abstract 16563: FOXO1 Induces Cardiomyocyte-KLF5, Which Drives Oxidative Stress and Diabetic Cardiomyopathy (2020) (0)
Abstract 298: Circular Rna Mmu_circ_008396 Attenuates Cardiac Remodeling After Myocardial Infarction in Mice (2017) (0)
- RhK: Rhodopsin kinase (vertebrates) (1995) (0)
Highlights of the 2010 scientific sessions of the Heart Failure Society of America, San Diego, California, September 12-15, 2010. (2011) (0)
Abstract 16788: Delivery of Pluripotent Stem Cell Specific Microrna-294 Induces Cardiomyocyte Proliferation Augmenting Cardiac Function After Myocardial Infarction (2014) (0)
718-3 Cardiac Overexpression of βARK in Transgenic Mice Inhibits Isoproterenol Stimulated Contractility In Vivo (1995) (0)
Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy (2003) (0)
Abstract P2065: Ischemic Injury Aggravated Muscle-specific Mir-499-5p-impaired Angiogenic Property Of Endothelial Cell In Hindlimb Of Diabetic Db/db Mice: Role Of Small Extracellular Vesicles (2022) (0)
GRK5‐mediated Exacerbation of Ischemic Heart Failure Involves Cardiac Immune and Inflammatory Responses (2019) (0)
Abstract 3862: Controlled Overexpression of Na+/Ca2+ Exchanger Does Not Lead to Heart Failure (2009) (0)
Abstract # 16325: Robust MCARD-mediated {beta}ARKct Expression in Ovine Ischemic Cardiomyopathy (2010) (0)
Abstract 381: Mcur1 is a Potential Target to Modulate Cardiac Contractility and Alleviate Cardiac Function During Heart Failure (2020) (0)
Abstract P3093: Gender-specific Functional Dimorphism Of Bone Marrow Endothelial Progenitor Cells: Estrogen Independent Epigenetic Mechanisms (2022) (0)
Abstract 10526: Surface Located Adiponectin On Adipocytes-derived Exosomes Mediates Adipocytes/cardiomyocytes Communication And Contributes To Cardioprotection (2021) (0)
Abstract 3392: G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Decreases Ischemia/Reperfusion Induced Myocardial Apoptosis and Improves Cardiac Function (2009) (0)
Adrenal beta-Arrestin 1 Mediates Physiological Production of Aldosterone In Vivo (2007) (0)
The GRK2 Inhibitor βARKct Enhances β2-Adrenergic Receptor-Dependent Cardiac Contractility In Vivo by Opposing Receptor Interaction with Phosphodiesterase Type 4D (2011) (0)
Lymphocyte G-protein coupled receptor kinase 2 and cardiac mortality in heart failure (2013) (0)
Abstract 14936: Circular Rna CircularFNDC3b Modulates Cardiac Repair After Myocardial Infarction (2017) (0)
, ARK 1 Upregulation Induced by Chronic Salt Deprivation in Rats β Cardiac (2001) (0)
Ca 2 (cid:2) entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance MAMMALIAN CELLS (2015) (0)
Commentary b-Adrenergic gene therapy for cardiovascular disease (2000) (0)
The Adrenergic System and Stem Cell-Mediated Myocardial Repair (2015) (0)
Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition (2022) (0)
Abstract 103: Cardiac Grk2 Blockade Augments β2-Adrenergic Receptor-Dependent Contractility and Survival Post Myocardial Infarction (2012) (0)
Abstract 220: Adipocyte-Derived Exosome-Containing miRNAs Exacerbated Cardiac Ischemia/Reperfusion Injury in Diabetic Mice (2018) (0)
386. Intra-Arterial Adenoviral Mediated |[beta]|2Adrenergic Receptor (AR) Gene Delivery Induces Neoangiogenesis in Rat Ischemic Hindlimb (2004) (0)
Percutaneous intracoronary adenoviral-mediated delivery and overexpression of the β2-adrenergic receptor in the normal and failing heart (1999) (0)
Abstract P2012: GRK2-Induced Cardiomyocyte AdipoR1 Phosphorylation Blocks Adipocytes-Derived Exosomes Cardioprotection Against Ischemic Heart Failure (2022) (0)
β-Adrenergic Receptor Desensitization in Cardiac Disease: Insights from Gene-Targeted Mice (2000) (0)
Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation (2013) (0)
Abstract P2022: Tipifarnib Mediated Protection By Reduction Of Circulating Exosomes In Pressure Overloaded Cardiac Hypertrophy (2022) (0)
Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts (2023) (0)
Selectively Targeting Gi Signaling in Normal and Dysfunctional Myocardium (2007) (0)
The putative beta four-adrenergic receptor is a novel state of the beta one-adrenergic receptor (2002) (0)
Abstract 5935: Genetic Deletion of {beta}-arrestin-1 Improves Function of the Infarcted Heart by Reducing Cardiac {beta}-adrenergic Receptor Desensitization and Cardiotoxic Neurohormonal Overstimulation (2009) (0)
Abstract 591: Expanding the therapeutic window through pharmacological activation of the RB pathway in breast cancer treatment (2011) (0)
Abstract 18646: The Dynamic Relationship Between GRK2 and NOS/NO Critically Determines Cardiac Ischemia/Reperfusion Injury (2012) (0)
CARDIAC AAV6-BETAARKCT GENE THERAPY RESCUES FAILING MYOCARDIUM AND NORMALIZES NEUROHORMONAL SIGNALING IN A CLINICALLY RELEVANT SWINE HEART FAILURE MODEL (2011) (0)
Coupling of (cid:98) 2 -Adrenoceptor to G i Proteins and Its Physiological Relevance in Murine Cardiac Myocytes (1999) (0)
Abstract 3222: When the L-type Ca2+ Current is Increased After Myocardial Infarction Determines if the Effects Will be Beneficial or Detrimental (2009) (0)
Differential Effects on Susceptibility to Ischemic Injury ARK 1 ) Inhibitor Both Increase Myocardial Contractility but Have β Receptor Kinase-1 (-Adrenergic β-Adrenergic Receptor and Expression of a 2 β Overexpression of the Cardiac (1999) (0)
Abstract 878: Wild Type A1 Adenosine Receptor and a Mutated A1 Adenosine Receptor Differentially Induced Cardiomyopathy Gene Expression In Transgenic Mouse Hearts (2006) (0)
Abstract 013: Role for β-Arrestins in Stem/Precursor Cell Function and Cardiac Regeneration (2013) (0)
G Protein-Coupled Receptors: Structure, Signaling, and Physiology “Beta adrenergic receptors in cardiovascular and respiratory disease (2010) (0)
Abstract 249: Plasma Exosomes Impair Angiogenesis in Ischemic Hind Limb of Diabetic Mice- Role of Histone Methylation (2020) (0)
Abstract P074: Loss of Function of TRPC4 Protects Against Cardiac Dysfunction Progression After Myocardial Infarction (2011) (0)
Abstract 15544: GRK2 RGS Domain-Specific Interaction With Gαq Inhibits Hypertrophy and Cardiac Dysfunction During Pressure Overload (2015) (0)
Abstract 106: Pluripotent Stem Cell Microrna-294 Induces Cardiomyocyte Proliferation and Augments Cardiac Function After Myocardial Infarction (2015) (0)
Abstract 15873: Modulation of Ischemic Neoangiogenesis by in vivo Gene Transfer and Manipulation of G Protein-Coupled Receptor Kinase-2 Activity: A Novel Role for the Peptide BARKct (2011) (0)
Abstract 185: Infliximab Suppresses TNF-a Induced Inflammatory Phenotype in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Formation (2013) (0)
Abstract 757: β-arrestin-Biased β2-Adrenergic Receptor Signaling Mediates Novel Mechanisms of Cardiomyocyte Contractility (2019) (0)
Abstract 13507: Human Cardiac Progenitor Cells Engineered with {beta}ARK-ct Have Increased Survival and Proliferation (2012) (0)
Abstract 292: Mitochondrial CLIC4 and CLIC5B Mediate Cardio-protection From Ischemia/reperfusion Injury (2018) (0)
Ark1-directed β2-adrenergic receptor coupling to Gi signaling leads to heart failure (2007) (0)
G-protein coupled receptor kinase 2 (GRK-2), a new regulator in the pathological cardiac hypertrophy by interacting NFAT signaling (2013) (0)
Abstract 18372: Bone Marrow Beta-Arrestin 1 and 2 in Outcomes of Myocardial Ischemic Injury: A Novel Role in Cardiac Regeneration (2010) (0)
Pharmacologic- and gene therapeutic-based inhibition of PKC α / β enhances cardiac contractility and attenuates heart failure (2009) (0)
Mitochondrial GRK2 is a Novel Regulator of Cardiac Energetics (2022) (0)
Abstract 373: Cigarette Smoke Produces Phenotypic Modulation of Cerebral Vascular Smooth Muscle Cells: Role of KLF4 and Epigenetic Control (2012) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Walter J Koch?

Walter J Koch is affiliated with the following schools:

Walter J Koch's Academic­Influence.com Rankings

Walter J Koch's Degrees

Similar Degrees You Can Earn

Why Is Walter J Koch Influential?

Walter J Koch's Published Works

Published Works

What Schools Are Affiliated With Walter J Koch?

Walter J Koch's AcademicInfluence.com Rankings