Walter Kolch

Q: What Schools Are Affiliated With Walter Kolch

Walter Kolch is affiliated with the following schools: National University of Ireland, Stanford University, University of Glasgow, University of California, San Francisco, University of Vienna

Walter Kolch's AcademicInfluence.com Rankings

Walter Kolch

Biology

#6784

World Rank

#9578

Historical Rank

Cell Biology

#236

World Rank

#244

Historical Rank

Molecular Biology

#726

World Rank

#743

Historical Rank

Neuroscience

#832

World Rank

#867

Historical Rank

biology Degrees

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Biology

Walter Kolch's Degrees

PhD Biochemistry University of California, San Francisco
Doctorate Medicine University of California, San Francisco

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Walter Kolch's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MAP kinase signalling pathways in cancer (2007) (2608)
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. (2000) (1483)
Protein kinase Cα activates RAF-1 by direct phosphorylation (1993) (1195)
Coordinating ERK/MAPK signalling through scaffolds and inhibitors (2005) (1096)
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP (1999) (856)
Signalling ballet in space and time (2010) (576)
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. (1993) (533)
Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. (1994) (494)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. (2006) (488)
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells (1991) (446)
Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease* (2010) (425)
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. (2007) (399)
Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells* (2001) (395)
Regulation and Role of Raf-1/B-Raf Heterodimerization (2006) (383)
Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein (2000) (378)
Protein kinase C alpha activates RAF-1 by direct phosphorylation. (1993) (369)
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. (2005) (350)
Epstein–Barr virus latent membrane protein‐1 triggers AP‐1 activity via the c‐Jun N‐terminal kinase cascade (1997) (348)
Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation (2001) (339)
Raf family kinases: old dogs have learned new tricks. (2011) (335)
Mechanism of inhibition of Raf-1 by protein kinase A (1994) (316)
Role of the Kinase MST2 in Suppression of Apoptosis by the Proto-Oncogene Product Raf-1 (2004) (311)
Clinical proteomics: A need to define the field and to begin to set adequate standards (2007) (303)
Recommendations for Biomarker Identification and Qualification in Clinical Proteomics (2010) (298)
Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts (1995) (297)
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity (2020) (295)
Cell fate decisions are specified by the dynamic ERK interactome (2009) (289)
Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. (2004) (287)
Regulation of Raf‐1 activation and signalling by dephosphorylation (2002) (279)
Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. (2005) (273)
The dynamic control of signal transduction networks in cancer cells (2015) (267)
Mutational activation of c-raf-1 and definition of the minimal transforming sequence (1990) (247)
The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier (2010) (237)
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259 (2002) (236)
Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis (2005) (235)
Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation* (2000) (225)
Reverse Signaling Through Transmembrane TNF Confers Resistance to Lipopolysaccharide in Human Monocytes and Macrophages1 (2000) (218)
Urinary Proteomic Biomarkers in Coronary Artery Disease*S (2008) (217)
Negative regulation of Raf-1 by phosphorylation of serine 621 (1996) (214)
Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. (2000) (207)
Functional proteomics to dissect tyrosine kinase signalling pathways in cancer (2010) (202)
Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry. (2004) (200)
Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNFα-Mediated NF-κ B Signal Transduction Pathway (2003) (199)
CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics (2008) (197)
Snail is a repressor of RKIP transcription in metastatic prostate cancer cells (2008) (195)
Untying the regulation of the Raf-1 kinase. (2002) (193)
Reduction in Raf Kinase Inhibitor Protein Expression Is Associated with Increased Ras-Extracellular Signal-Regulated Kinase Signaling in Melanoma Cell Lines (2004) (190)
The role of MAPK pathways in the action of chemotherapeutic drugs. (2002) (187)
When kinases meet mathematics: the systems biology of MAPK signalling (2005) (184)
Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. (2006) (181)
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. (2001) (177)
Regulation of Raf‐1 kinase activity by the 14‐3‐3 family of proteins. (1995) (177)
Evaluating Strategies to Normalise Biological Replicates of Western Blot Data (2014) (175)
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway (2009) (175)
MAP kinase signaling pathways in cancer. Oncogene (2007) (172)
Conferring specificity on the ubiquitous Raf/MEK signalling pathway (2004) (172)
Computational Approaches for Analyzing Information Flow in Biological Networks (2012) (171)
PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase. (1996) (170)
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling (2013) (168)
A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK Pathways (2007) (158)
Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models (2008) (155)
Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. (2002) (152)
Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. (2010) (150)
Big signals from small particles: regulation of cell signaling pathways by nanoparticles. (2013) (145)
Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. (2009) (144)
Comprehensive human urine standards for comparability and standardization in clinical proteome analysis (2010) (142)
Modeling and simulation of intracellular dynamics: choosing an appropriate framework (2004) (141)
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. (1991) (136)
Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients (2015) (135)
The secret life of kinases: functions beyond catalysis (2011) (134)
Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5 (2006) (134)
Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches (2016) (132)
Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: Towards new diagnostic and therapeutic approaches (2005) (126)
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling (2014) (125)
On-Beads Digestion in Conjunction with Data-Dependent Mass Spectrometry: A Shortcut to Quantitative and Dynamic Interaction Proteomics (2014) (124)
Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades (2012) (122)
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. (2011) (121)
Regulation of Raf‐1 kinase by TNF via its second messenger ceramide and cross‐talk with mitogenic signalling (1998) (121)
Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β. (2011) (120)
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. (2005) (118)
Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway (2003) (118)
Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers (2010) (117)
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products. (1994) (115)
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. (1990) (104)
The molecular make-up of a tumour: proteomics in cancer research. (2005) (104)
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. (2010) (102)
The role of Raf kinases in malignant transformation (2002) (101)
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. (2010) (100)
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. (2011) (98)
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. (2010) (94)
Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90* (1996) (92)
Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: a critical assessment. (2009) (90)
Theoretical and experimental analysis links isoform- specific ERK signalling to cell fate decisions (2009) (86)
RASSF2 associates with and stabilizes the proapoptotic kinase MST2 (2009) (86)
Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction. (2006) (86)
Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development (2014) (84)
The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873 (2016) (83)
Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf (1994) (81)
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise (2012) (80)
MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability (2009) (80)
Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein. (1991) (80)
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation (2018) (78)
Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability (2008) (77)
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis (2004) (77)
The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways (2010) (75)
Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species (2010) (73)
Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (2010) (73)
Phosphatase and Feedback Regulation of Raf-1 Signaling (2007) (73)
GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling (2013) (72)
ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2 (2012) (71)
Activation of the Epstein-Barr Virus Transcription Factor BZLF1 by 12-O-Tetradecanoylphorbol-13-Acetate-Induced Phosphorylation (1998) (69)
Protein kinase C-ε associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity (1997) (68)
Oncogenic B-Raf mutations: crystal clear at last. (2004) (68)
Comparison of anthracycline-induced death of human leukemia cells: Programmed cell death versus necrosis (2002) (67)
MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance. (2016) (67)
High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion protein. (2007) (67)
Ras/Raf signalling and emerging pharmacotherapeutic targets (2002) (67)
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway (2009) (67)
HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways. (2014) (66)
Taming the Hippo: Raf-1 Controls Apoptosis by Suppressing MST2/Hippo (2005) (66)
Identification and analysis of phosphopeptides. (2004) (66)
The Raf‐1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments (2000) (66)
Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway. (2005) (63)
LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway (2004) (61)
The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1. (2000) (59)
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells (1997) (57)
An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter. (1991) (57)
A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation (2003) (56)
RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. (2011) (52)
Targeting MAPK signalling: Prometheus' fire or Pandora's box? (2004) (52)
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2 (2013) (51)
Regulation of RKIP binding to the N‐region of the Raf‐1 kinase (2006) (51)
Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. (2009) (51)
One Hippo and many masters: differential regulation of the Hippo pathway in cancer. (2014) (51)
c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway. (2011) (50)
Phosphodiesterase-8A binds to and regulates Raf-1 kinase (2013) (50)
Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network. (1998) (50)
Cell Type-Specific Activation of AKT and ERK Signaling Pathways by Small Negatively-Charged Magnetic Nanoparticles (2012) (49)
Induction of Apoptosis by Protein Kinase Cδ Is Independent of Its Kinase Activity* (2002) (49)
Raf kinase inhibitor protein regulation of raf and MAPK signaling. (2006) (48)
Integrating network reconstruction with mechanistic modeling to predict cancer therapies (2016) (45)
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch. (2009) (44)
Regulation of human myoblast differentiation by PEBP4 (2009) (44)
Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. (2008) (44)
The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. (2008) (44)
Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008) (2009) (43)
Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia (2012) (43)
Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling. (2018) (42)
Proteomics and phosphoproteomics for the mapping of cellular signalling networks (2008) (42)
Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells. (1996) (41)
A Hippo in the ointment: MST signalling beyond the fly (2008) (40)
Lab-on-a-chip technologies for proteomic analysis from isolated cells (2008) (39)
RAN GTPase Is a RASSF1A Effector Involved in Controlling Microtubule Organization (2009) (39)
Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2. (2007) (39)
Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System (2011) (37)
Erbin: Sorting Out ErbB2 Receptors or Giving Ras a Break? (2003) (35)
Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation (2015) (35)
Eukaryotic Translation Initiation Factor 3, Subunit a, Regulates the Extracellular Signal-Regulated Kinase Pathway (2011) (35)
It takes two to tango--signalling by dimeric Raf kinases. (2013) (35)
The topology design principles that determine the spatiotemporal dynamics of G-protein cascades. (2012) (35)
Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3. (2006) (35)
Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades (2012) (35)
Systems medicine: helping us understand the complexity of disease. (2013) (34)
Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation (2019) (33)
Lab-on-a-chip technologies for proteomic analysis from isolated cells. (2008) (33)
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D (2020) (32)
Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity. (1997) (32)
BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research (2016) (32)
Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology (2013) (32)
Giving Space to Cell Signaling (2008) (32)
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. (2008) (31)
RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy (2020) (31)
Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma (2015) (31)
A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model (2017) (30)
Engineering the serine/threonine protein kinase Raf‐1 to utilise an orthogonal analogue of ATP substituted at the N 6 position (2004) (30)
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter (2017) (29)
Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration (2020) (29)
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance (2017) (29)
An Integrated Global Analysis of Compartmentalized HRAS Signaling. (2019) (29)
The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics (2013) (28)
The APC network regulates the removal of mutated cells from colonic crypts. (2014) (27)
Wnt signalling is a bi-directional vulnerability of cancer cells (2016) (27)
Regulation of the MAPK pathway by raf kinase inhibitory protein. (2014) (27)
Molecular mechanisms of asymmetric RAF dimer activation. (2014) (27)
Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. (1999) (27)
Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity (2013) (26)
Mapping of signaling pathways by functional interaction proteomics. (2008) (26)
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer (2019) (25)
Probing structure and function of the raf protein kinase domain with monoclonal antibodies. (1990) (25)
Clinical proteomics: a question of technology. (2004) (25)
Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies (2014) (24)
Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding. (1996) (24)
Robustness and Evolvability of the Human Signaling Network (2014) (24)
On-chip immunoprecipitation for protein purification. (2010) (24)
Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models. (2010) (24)
Multiple roles of the NF‐?B signaling pathway regulated by coupled negative feedback circuits (2009) (23)
Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses (2014) (23)
Mechanochemical Stimulation of MCF7 Cells with Rod‐Shaped Fe–Au Janus Particles Induces Cell Death Through Paradoxical Hyperactivation of ERK (2015) (23)
A novel RNA sequencing data analysis method for cell line authentication (2017) (23)
A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells (2012) (23)
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device (2015) (22)
Network-based identification of feedback modules that control RhoA activity and cell migration. (2015) (22)
Systems biology‐embedded target validation: improving efficacy in drug discovery (2014) (21)
Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum. (1993) (20)
A microfluidic dual gradient generator for conducting cell-based drug combination assays. (2016) (20)
Induction of apoptosis by protein kinase C delta is independent of its kinase activity. (2002) (19)
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells (2013) (19)
Linear Approaches to Intramolecular Förster Resonance Energy Transfer Probe Measurements for Quantitative Modeling (2011) (19)
Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy (2004) (19)
Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis* (2016) (19)
Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1α activity. (2014) (18)
Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses. (2015) (18)
The Ins and Outs of RAS Effector Complexes (2021) (18)
Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli. (1988) (17)
Differential Role of Protein Kinase C in Cytokine Induced Lymphocyte‐Endothelium Interaction In Vitro (1994) (17)
Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA) (2010) (17)
The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway. (2010) (17)
The spatiotemporal regulation of RAS signalling. (2016) (17)
Precision therapy in RAS mutant colorectal cancer. (2020) (16)
The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways. (2003) (16)
Retracted: Mice lacking the Raf‐1 kinase inhibitor protein exhibit exaggerated hypoxia‐induced pulmonary hypertension (2011) (16)
Silence on the relevant literature and errors in implementation (2015) (16)
To be or not to be: a question of B-Raf? (2001) (16)
The Renilla luciferase gene as a reference gene for normalization of gene expression in transiently transfected cells (2010) (16)
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention. (2017) (15)
Personalized Computational Models as Biomarkers (2017) (15)
Role of inhibitory proteins as modulators of oscillations in NFB signalling. (2009) (15)
Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients (2013) (15)
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints. (2020) (15)
SARAH Domain-Mediated MST2-RASSF Dimeric Interactions (2016) (14)
Control of the G-protein cascade dynamics by GDP dissociation inhibitors. (2013) (14)
Raf-1 and B-Raf promote protein kinase C θ interaction with BAD (2007) (14)
Identification of the smooth muscle‐specific protein, sm22, as a novel protein kinase C substrate using two‐dimensional gel electrophoresis and mass spectrometry (2000) (14)
PI 3 K / Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI 3 K-mutant T 47 D breast cancer cells (13)
MST2-RASSF protein-protein interactions through SARAH domains (2016) (13)
ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells (2015) (13)
Mammalian protein expression noise: scaling principles and the implications for knockdown experiments. (2012) (13)
Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation (2016) (13)
Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis (2019) (12)
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation (2015) (12)
Raf-1 and B-Raf promote protein kinase C theta interaction with BAD. (2007) (12)
Defining systems biology: through the eyes of a biochemist. (2008) (12)
Measuring Transcription Rate Changes via Time-Course 4-Thiouridine Pulse-Labelling Improves Transcriptional Target Identification. (2015) (12)
Signalling mechanisms regulating phenotypic changes in breast cancer cells (2015) (11)
Prolonged vs transient roles for early cell cycle signaling components (1998) (11)
Accurate prediction of kinase-substrate networks using knowledge graphs (2019) (11)
Biology using engineering tools (2011) (11)
Control of cell state transitions (2022) (11)
Quantification of Functionalised Gold Nanoparticle-Targeted Knockdown of Gene Expression in HeLa Cells (2014) (11)
Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors (2020) (10)
Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing (2017) (10)
Dynamics of receptor and protein transducer homodimerisation (2008) (10)
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention (2017) (10)
Metabolic stress regulates ERK activity by controlling KSR‐RAF heterodimerization (2018) (9)
Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling (2021) (9)
Reasoning about the ERK signal transduction pathway using (2005) (8)
Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation. (2014) (8)
An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity. (2019) (8)
A systematic analysis of signaling reactivation and drug resistance (2020) (8)
Emerging RAS-directed therapies for cancer (2021) (8)
Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration (2014) (8)
Spatial regulation of ARAF controls the MST2-Hippo pathway (2017) (7)
An integrated Bayesian framework for identifying phosphorylation networks in stimulated cells. (2012) (7)
Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte‐Induced Lysis (2016) (7)
KBoost: a new method to infer gene regulatory networks from gene expression data (2021) (6)
When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization (2009) (6)
Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease (2016) (6)
Systems medicine: opportunities and challenges for systems biology approaches (2013) (5)
Unique Reporter-Based Sensor Platforms to Monitor Signalling in Cells (2012) (5)
Mathematical Systems Biology: Genomic Cybernetics (2004) (5)
Mathematical Systems Biology: Genomic Cybernetics (2004) (5)
Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF. (2016) (5)
Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF. (2016) (5)
Semantic Data Integration for Francisella tularensis novicida Proteomic and Genomic Data (2008) (4)
From oncogenic mutation to dynamic code (2018) (4)
Cell Type-Specific Activation of AKT and ERK Signaling Pathways by Small Negatively-Charged Magnetic (2012) (4)
REDUCTION OF RAF-1 KINASE INHIBITOR PROTEIN ( RKIP ) EXPRESSION IN BREAST CANCER METASTASES (2005) (4)
A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas. (1990) (3)
Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response (2021) (3)
Excitable Responses and Oscillations in the Ring 1 B / Bmi 1 Ubiquitination System (3)
Activation of bcl‐2 suppressible 40 and 44 kDa p38‐like kinases during apoptosis of early and late B lymphocytic cell lines (1998) (3)
A Bayesian Analysis of the ERK Signalling Pathway (2006) (3)
Tumor and Stem Cell Biology Cancer Research Heterogeneous Nuclear Ribonucleoprotein H Blocks MST 2-Mediated Apoptosis in Cancer Cells by Regulating araf Transcription (2010) (3)
Exploration of homodimer receptor: homodimer protein interactions (2009) (3)
suppressing expression of Rab17 and Liprin- 2 (2012) (3)
Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts. (1998) (2)
Genomics, Proteomics and Metabolomics (2009) (2)
Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma (2022) (2)
Expression of human c-raf-1 oncogene proteins in E. coli. (1988) (2)
A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma (2021) (2)
Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models (2017) (2)
The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks. (2005) (2)
Addressing the challenge of dening valid proteomic biomarkers and classiers. (2011) (2)
Cancer esearch rated Systems and Technologies ctional Roles of Multiple Feedback Loops in Extracellular al-Regulated Kinase and Wnt Signaling Pathways R t Regulate Epithelial-Mesenchymal Transition (2010) (2)
A comparative analysis of extracellular vesicles (EVs) from human and feline plasma (2022) (2)
B-cell and complement signature in severe hidradenitis suppurativa that does not respond to adalimumab. (2022) (1)
Raf Function Is Required for Proliferation of NIH|3T3 Cells and Transformation by Nonnuclear Oncogenes (1992) (1)
Targeting KRAS in Pancreatic Cancer (2022) (1)
Biology using engineering tools: The negative feedback amplifier (2017) (1)
Molecular and Cellular Pathobiology Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3 b (2011) (1)
Abstract 2878: The tumor-permissive role of KHSRP in colorectal cancer: Mechanistic insights from a gene expression study (2016) (1)
Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D. (2017) (1)
Identification of a MYCN and Wnt-related VANGL2-ITLN1 fusion gene in neuroblastoma (2018) (1)
Oncotherapeutic Strategies in Early Onset Colorectal Cancer (2023) (1)
ADP-Ribosylation Factor-Like 8B (2012) (1)
The future of genomics in Ireland – focus on genomics for health (2020) (1)
MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21 Stability (2009) (1)
A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin (2022) (1)
Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation (2019) (1)
Author response: Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration (2020) (1)
Integrating network reconstruction with mechanistic modelling to predict potential cancer therapy (1)
Transcriptional regulatory mechanisms of fibrosis development in mouse lung tissue exposed to carbon nanotubes (2018) (1)
Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing. (2020) (1)
Raf kinase inhibitor protein (RKIP), lympho-vascular invasion and peritoneal invasion can be used to identify a high-risk group of stage II colorectal cancer patients (2012) (1)
Towards an Understanding of the Dynamics of Life (2003) (1)
Analysis of Alternative mRNA Splicing in Vemurafenib-Resistant Melanoma Cells (2022) (1)
In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells. (2014) (1)
Signalling ballet in four dimensions (2017) (0)
How does a cell in an organism differentiate signals from noise while being immersed in bath of growth factors and hormones? This issue is one of the major challenges in understanding how the high fidelity and specificity of biological responses (0)
Dynamic regulation of RAS and RAS signaling (2023) (0)
- 1-c-Myc regulates ARaf kinase splicing and ERK pathway activation (2017) (0)
Cancer Cells Cytoskeletal Organization , Adhesion , and Motility in Colon Is Required to Maintain Changes in KRAS Oncogenic (2005) (0)
Title Inferring Signaling Pathway Topologies from MultiplePerturbation Measurements of Specific Biochemical Species (2018) (0)
Theoretical and experimental analysis links isoform-speciﬁc ERK signalling to cell fate decisions (2017) (0)
The ERBB pathway that regulates the G 1 / S transition (2012) (0)
Title Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition (2017) (0)
ERK regulates RhoA activation and tumour cell plasticity by inhibiting GEF-H 1 1 activity 2 (0)
B-cell-derived transforming growth factor-β may drive the activation of inflammatory macrophages and contribute to scarring in hidradenitis suppurativa. (2022) (0)
c-Myc regulates A-Raf kinase splicing and ERK path- way activation (2017) (0)
ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells (2015) (0)
Evolutionarily Conserved Wnk and Ste20 Kinases Are Essential for Acute Volume Recovery and Survival after Kinase to Regulate P21waf1/cip1 Stability Mst Kinases Monitor Actin Cytoskeletal Integrity and Signal via C-jun N-terminal Kinase Stress-activated Small-molecule P21-activated Kinase Inhibitor P (2006) (0)
Proteomics in research and clinic (2007) (0)
prostate cancer signaling pathways (2015) (0)
Retracted: Mice lacking the Raf‐1 kinase inhibitor protein exhibit exaggerated hypoxia‐induced pulmonary hypertension, by I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair and MR MacLean. British Journal of Pharmacology, volume 163(5): 948–963, published in June 2011; DOI 10.1111/j.1476‐5381.2011.0130 (2017) (0)
Association ofMEK1 withp21ras GMPPNP IsDependent on B-Raf (1994) (0)
controlling ARaf splicing in hepatocellular carcinoma development Splicing factor hnRNP A 2 activates the Ras-MAPK-ERK pathway by Material Supplemental (2014) (0)
Loss of RAF Kinase Inhibitor Protein Is a Frequent Event In Acute Myeloid Leukemia with a Monocytic Phenotype and Cooperates with Mutant RAS In Malignant Transformation (2010) (0)
PO-311 Characterisation of colorectal tumour endothelial cells (2018) (0)
Ankyrine-Rich TRP Channel, ANKTM1, TRPA1 (2012) (0)
Signalling ballet in four dimensions Supplementary Information (0)
A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model (2017) (0)
PO-136 Studying pathway interactions and dynamics to predict cell responses to chemotherapeutic treatment in breast cancer cells (2018) (0)
Tumor and Stem Cell Biology c-Myc Regulates RNA Splicing of the ARaf Kinase and Its Activation of the ERK Pathway (2011) (0)
P31: Use of omics technology for the identification of critical mediators and pathways in patients with hidradenitis suppurativa (2021) (0)
Title PI 3 K / Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI 3 K-mutant T 47 D breast cancer cells (2017) (0)
Cancer Biology and Signal Transduction GSK 3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms , Including p 53 and Wnt Signaling (2014) (0)
White paper: The International Receptor Tyrosine Kinase Networks Consortium (2005) (0)
Effects of RKIP Loss in Human and in Animal Models of Colorectal Cancer (2011) (0)
Additional file 3: Figure S3. of ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells (2015) (0)
Small gene networks can delineate immune cell states and characterize immunotherapy response in melanoma (2022) (0)
Essays In Biochemistry: 62 (4) (2018) (0)
Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease (2016) (0)
Details of the Bayesian formalisms (2013) (0)
533: Proteomic profiling of N-Myc-associated proteins in neuroblastoma (2014) (0)
Deciphering the Tumour Immune Microenvironment Cell by Cell (2023) (0)
BHS Abstracts (2006) (0)
Adaptive rewiring of protein-protein interactions and signal flow in the EGFR signaling network by mutant RAS (2018) (0)
A database of naturally occurring human urinary peptides and proteins for use in clinical applications (2007) (0)
P30: Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink (2021) (0)
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer (2019) (0)
Abstract 658: CRABP2 - a novel biomarker for high risk endometrial cancer (2021) (0)
Interactome dynamics of RAF1-BRAF kinase monomers and dimers (2023) (0)
THE RASSF8 CANDIDATE TUMOUR SUPPRESSOR INHIBITS CELL GROWTH AND REGULATES THE WNT AND NF-ΚB SIGNALLING PATHWAYS VIA ADHERENS JUNCTIONS (0)
Introduction into the Concept of Systems Medicine (2018) (0)
Analysis of the mechanisms through which K-RASG12V and K-RASG13D regulate the proliferation and cell death in cells HT-29 (2014) (0)
Additional file 6: Figure S6. of ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells (2015) (0)
Adenylyl Cyclase Inhibitory Gi Alpha Subunit (2012) (0)
Author Correction: Cell fate decisions are specified by the dynamic ERK interactome (2022) (0)
Title HGF induces epithelial-to-mesenchymal transition bymodulating the mammalian Hippo / MST 2 and ISG 15 pathways (2017) (0)
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling (2013) (0)
Choosing an appropriate modeling framework: How deteministic are random processes? (2004) (0)
1 Evaluating Strategies to Normalise Biological Replicates of Western Blot Data 1 (0)
Title Functional proteomics to dissect tyrosine kinase signallingpathways in cancer (2017) (0)
Su2021 The Tumor-Permissive Role of KHSRP as a Target for the Polyphenol Resveratrol: Potential Tumor-Suppressive Effects in a Pre-Clinical Model of Colorectal Cancer (2016) (0)
Edinburgh Research Explorer Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D in (2020) (0)
05.02 Differentiating patient responses in rheumatoid arthritis – systems analysis of key molecular networks (2017) (0)
VEGF promotes assembly of the p 130 Cas interactome to drive endothelial chemotactic signalling and angiogenesis (2016) (0)
121 Mass Spectrometry-based Proteome Analysis of Skin Microdialysates (2019) (0)
Pachinko biology: Gambling on single cells (2009) (0)
11 From benchside to byteside: what we can learn from computational modelling (2010) (0)
Regulation ofRaf-1 kinase activity bythe14-3-3 family ofproteins (1995) (0)
Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks (2015) (0)
KSR proteins link metabolic changes to the MAPK/ERK pathway (2016) (0)
Understanding Cell Fate Decisions by Identifying Crucial System Dynamics (2012) (0)
SP-0220 Precision medicine and systems biology - transforming cancer research in the 21st century (2019) (0)
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma (2023) (0)
498 Metastatic high grade serous ovarian cancer has an immune excluded tumor microenvironment – explaining failure of immunotherapy to date (2021) (0)
TBP-1 subunit of the 19S proteasome cooperates with an ERK-regulated degron to regulate turnover of the Fra-1/AP-1 transcription factor (2016) (0)
Abca (1981) (0)
Proteomic technologies and targets: an overview (2013) (0)
TITLE: The spatiotemporal regulation of RAS signalling (0)
Design principles for information processing through signalling networks (2010) (0)
FD 175 : In vitro Study of the Interaction of Heregulin Functionalized Magnetic-Optical Nanorods with MCF 7 and MDA-MB-231 Cells (2014) (0)
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter (2017) (0)
P29: Routine screening with early‐morning cortisol facilitates identification and improves management of adrenal insufficiency in glucocorticoid‐treated dermatology patients (2021) (0)
CRABP2 - A novel biomarker for high-risk endometrial cancer. (2022) (0)
Title Mutant KRas Activation of the Proapoptotic MST 2 Pathway (2017) (0)
Additional file 5: Figure S5. of ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells (2015) (0)
Systems biology: old news or new stimulus for biochemistry. (2018) (0)
Role of raf and myc Oncogenes in Signal Transduction (2020) (0)
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance (2017) (0)
Title Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease (0)
Suppressor genes of V-RAF transformation: protein kinase C-ξ reverts cellular transformation by inducing prolonged expression of junB and EGR-1 (2007) (0)
Running title : A framework for pathway inference and modelling Character count : 48856 (2017) (0)
PO-461 Mitochondria-mediated anticancer effect of diphenyleneiodonium chloride (DPI) in aggressive neuroblastoma is regulated by MYCN (2018) (0)
All over the place: deciphering HRAS signaling from different subcellular compartments (2019) (0)
Codon 12 and codon 13 mutations in K-RAS differentially affect colorectal carcinoma cells (2014) (0)
Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells (2022) (0)
Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes (2021) (0)

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