Walter Rosenthal

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Walter Rosenthal is affiliated with the following schools: Humboldt University of Berlin, Free University of Berlin, Technical University of Munich, University of Giessen

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Walter Rosenthal

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#651

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#870

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Pharmacology

#57

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#78

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Why Is Walter Rosenthal Influential?

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According to Wikipedia, Walter Rosenthal is a German physician, pharmacologist & science manager, and President of the German Rectors' Conference since May 2023. Prior to that, he was the President of the Friedrich Schiller University Jena . From 2009 to 2014, he was the foundation board member and scientific director of the Max Delbrück Center for Molecular Medicine in Berlin-Buch. From 1996 to 2008 he headed what is today the Leibniz Research Institute for Molecular Pharmacology .

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Walter Rosenthal's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The GTP-binding protein, Go9 regulates neuronal calcium channels (1987) (839)
Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents (1991) (569)
Molecular cloning of the receptor for human antidiuretic hormone (1992) (504)
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. (1991) (496)
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus (1992) (319)
Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. (2000) (258)
AKAP complex regulates Ca2+ re‐uptake into heart sarcoplasmic reticulum (2007) (190)
Mechanisms of protein kinase A anchoring. (2010) (179)
Protein Kinase A Anchoring Proteins Are Required for Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells* (1999) (177)
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase. (1993) (163)
An Inhibitory Role of Rho in the Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells* (2001) (162)
A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells. (1998) (154)
Pharmacochaperones Post-translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-type and Mutant Vasopressin V2 Receptors* (2004) (152)
X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis. (1993) (150)
Regulation of aquaporin-2 trafficking. (2009) (150)
Role of G proteins in calcium channel modulation. (1990) (149)
Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for Its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells* (2004) (147)
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. (2007) (146)
Ligand-dependent Differences in the Internalization of Endothelin A and Endothelin B Receptor Heterodimers* (2004) (139)
Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus. (1994) (138)
cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI (2003) (135)
Control of voltage‐dependent Ca2+ channels by G protein‐coupled receptors (1988) (130)
Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus. (2002) (130)
A Role of Myosin Vb and Rab11‐FIP2 in the Aquaporin‐2 Shuttle (2007) (125)
Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells. (2001) (125)
The molecular basis of nephrogenic diabetes insipidus (1998) (124)
Structure and chromosomal localization of the human antidiuretic hormone receptor gene. (1992) (122)
Angiotensin II‐induced stimulation of voltage‐dependent Ca2+ currents in an adrenal cortical cell line. (1988) (121)
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho (2003) (113)
Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. (2002) (108)
Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor. (2000) (102)
Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes* (2010) (99)
The mechanisms of aquaporin control in the renal collecting duct. (2000) (98)
Encyclopedia of Molecular Pharmacology (2008) (94)
Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. (2010) (92)
Disease‐causing V2 Vasopressin Receptors are Retained in Different Compartments of the Early Secretory Pathway (2004) (91)
Cyclic AMP‐independent, dual regulation of voltage‐dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line. (1988) (85)
Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils (1986) (83)
Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. (1988) (82)
Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye. (1985) (80)
Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin‐2 in renal epithelial cells (2003) (78)
Properties of the human arginine vasopressin V2 receptor after site-directed mutagenesis of its putative palmitoylation site. (1996) (77)
Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells. (2003) (76)
Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function. (1996) (76)
Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells (2002) (76)
A Heterotrimeric G Protein of the Gi Family Is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells* (1998) (75)
An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system. (1994) (72)
The Signal Peptide of the G Protein-coupled Human Endothelin B Receptor Is Necessary for Translocation of the N-terminal Tail across the Endoplasmic Reticulum Membrane* (2002) (70)
Actin remodeling requires ERM function to facilitate AQP2 apical targeting (2005) (70)
Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C‐terminus (1998) (70)
Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. (1991) (67)
The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process* (2002) (66)
Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells. (1998) (64)
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling1 (2001) (63)
Identification of Rab3‐, Rab5a‐ and synaptobrevin II‐like proteins in a preparation of rat kidney vesicles containing the vasopressin‐regulated water channel (1995) (62)
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells. (2008) (62)
[25] Identification of receptor-activated G proteins with photoreactive GTP analog, [α-32P]GTP azidoanilide (1991) (61)
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. (2006) (58)
The Corticotropin-releasing Factor Receptor Type 2a Contains an N-terminal Pseudo Signal Peptide* (2006) (57)
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. (2006) (57)
Fluorescence Resonance Energy Transfer Analysis Reveals the Existence of Endothelin-A and Endothelin-B Receptor Homodimers (2004) (55)
Aquaporin-1, Nothing but a Water Channel* (2004) (55)
The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. (1988) (53)
Glycogen Synthase Kinase 3β Interaction Protein Functions as an A-kinase Anchoring Protein* (2009) (53)
Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation. (2001) (50)
Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells. (2007) (49)
Congenital nephrogenic diabetes insipidus. (1997) (49)
Functional Rescue of the Nephrogenic Diabetes Insipidus-causing Vasopressin V2 Receptor Mutants G185C and R202C by a Second Site Suppressor Mutation* (2001) (48)
The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor. (2005) (46)
Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor. (2000) (46)
Arrestin-Independent Internalization and Recycling of the Urotensin Receptor Contribute to Long-Lasting Urotensin II–Mediated Vasoconstriction (2005) (45)
A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family. (1990) (44)
Identification and characterization of the 35-kDa beta subunit of guanine-nucleotide-binding proteins by an antiserum raised against transducin. (1986) (44)
Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells. (2001) (44)
Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus (1996) (43)
Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go (1988) (43)
Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions** (2013) (42)
Tissue distribution of β1- and β2-subunits of regulatory guanine nucleotide-binding proteins (1989) (42)
Membrane Targeting and Determination of Transmembrane Topology of the Human Vasopressin V2 Receptor* (1996) (40)
The hydrophobic amino acid residues in the membrane‐proximal C tail of the G protein‐coupled vasopressin V2 receptor are necessary for transport‐competent receptor folding (2005) (40)
Agonist‐sensitive binding of a photoreactive GTP analog to a G‐protein α‐subunit in membranes of HL‐60 cells (1990) (39)
Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus. (1994) (39)
Resolution of transducin subunits by chromatography on blue sepharose. (1987) (38)
A Single Negatively Charged Residue Affects the Orientation of a Membrane Protein in the Inner Membrane of Escherichia coliOnly When It Is Located Adjacent to a Transmembrane Domain* (1999) (38)
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin. (1988) (37)
Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate. Evidence for the involvement of various guanine nucleotide-binding proteins. (1992) (37)
Mutations in the vasopressin V2 receptor gene in families with nephrogenic diabetes insipidus and functional expression of the Q-2 mutant. (1994) (36)
Modulations of voltage-dependent ion channels by extracellular signals (1987) (35)
Rescue of a Nephrogenic Diabetes Insipidus-causing Vasopressin V2 Receptor Mutant by Cell-penetrating Peptides* (2007) (35)
Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB (2009) (33)
Derlin-1 and p97/Valosin-Containing Protein Mediate the Endoplasmic Reticulum-Associated Degradation of Human V2 Vasopressin Receptors (2008) (33)
Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity. (2002) (32)
Immunochemical detection of the alpha-subunit of the G-protein, GZ, in membranes and cytosols of mammalian cells. (1988) (31)
Polarized cell surface expression of the green fluorescent protein‐tagged vasopressin V2 receptor in Madin Darby canine kidney cells (1998) (30)
Encyclopedic reference of molecular pharmacology (2004) (28)
Functional significance of cleavable signal peptides of G protein-coupled receptors. (2012) (28)
Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells. (1991) (28)
N-Terminal Proteolysis of the Endothelin B Receptor Abolishes Its Ability to Induce EGF Receptor Transactivation and Contractile Protein Expression in Vascular Smooth Muscle Cells (2006) (28)
Peptides for disruption of PKA anchoring. (2006) (27)
Heterogeneity of three electrophoretically distinct Go α‐subunits in mammalian brain (1992) (26)
The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues (2000) (26)
G-protein α-subunits in cytosolic and membranous fractions of human neutrophils (1989) (25)
Identification of the G-protein α-subunit encoded by αo2 cDNA as a 39 kDa pertussis toxin substrate (1991) (25)
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells. (1991) (24)
Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2. (2005) (24)
Inhibition of voltage-dependent Ca2+ channels via α2-adrenergic and opioid receptors in cultured bovine adrenal chromaffin cells (1992) (23)
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line. (1989) (21)
The Sequence after the Signal Peptide of the G Protein-Coupled Endothelin B Receptor Is Required for Efficient Translocon Gating at the Endoplasmic Reticulum Membrane (2009) (21)
Differential sensitivity to guanine nucleotides of basal and insulin‐stimulated glucose transporter activity reconstituted from adipocyte membrane fractions (1989) (21)
Small-molecule screening identifies modulators of aquaporin-2 trafficking. (2013) (21)
G protein function in the ischaemic myocardium. (1991) (20)
NADP efficiently inhibits endogenous but not pertussis toxin‐catalyzed co valent modification of membrane proteins incubated with NAD (1987) (20)
Use of Kaede Fusions to Visualize Recycling of G Protein‐Coupled Receptors (2009) (20)
Degradation of inositol 1,3,4,5-tetrakisphosphates by porcine brain cytosol yields inositol 1,3,4-trisphosphate and inositol 1,4,5-trisphosphate. (1988) (20)
Inhibition of Biosynthesis of Human Endothelin B Receptor by the Cyclodepsipeptide Cotransin* (2011) (19)
Identification of receptor-activated G proteins with photoreactive GTP analog, [alpha-32P]GTP azidoanilide. (1991) (19)
Culturing primary rat inner medullary collecting duct cells. (2013) (19)
Updated protocols and comments on the purification without use of activating ligands of the coupling proteins Ns and Ni of the hormone sensitive adenylyl cyclase. (1984) (17)
GTPases in Biology II (1993) (17)
In vitro synthesis of 32P-labelled phosphatidylinositol 4,5-bisphosphate and its hydrolysis by smooth muscle membrane-bound phospholipase C. (1987) (15)
Polarized expression of the vasopressin V2 receptor in Madin-Darby canine kidney cells. (1999) (15)
Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands. (1985) (14)
Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes. (1992) (13)
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha. (1994) (12)
Pertussis toxin-sensitive G-proteins: participation in the modulation of voltage-dependent Ca2+ channels by hormones and neurotransmitters. (1990) (12)
Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels. (1988) (12)
Receptor- and G-protein-mediated modulations of voltage-dependent calcium channels. (1988) (10)
Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein. (2000) (10)
Endothelin A and Endothelin B Receptors Differ in Their Ability to Stimulate ERK1/2 Activation (2006) (9)
Immunocytochemical localization of G-proteins (α subunits) in rat heart tissue (1991) (9)
Heterogeneity of three electrophoretically distinct Go alpha-subunits in mammalian brain. (1992) (9)
Expression cloning of the human V2 vasopressin receptor (1993) (8)
Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production. (1992) (8)
Cloning of the Human Type‐2 Vasopressin Receptor Gene (1993) (7)
Topology of eukaryotic multispanning transmembrane proteins: use of LacZ fusions for the localization of cytoplasmic domains in COS.M6 cells. (1997) (6)
The vasopressin type 2 receptor gene. Chromosomal localization and its role in nephrogenic diabetes insipidus (1993) (5)
[Principles of transmembranous signal transduction in the action of hormones and neurotransmitters]. (1985) (5)
The cytosolic G‐protein α‐subunit in human neutrophils responds to treatment with guanine nucleotides and magnesium (1989) (5)
CHAPTER 16 – Receptor—Ion Channel Coupling through G Proteins (1990) (5)
Chapter 7 Two genes-one disease: The molecular basis of congenital nephrogenic diabetes insipidus (1998) (4)
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. (1989) (4)
STRUCTURAL AND FUNCTIONAL PROPERTIES OF NS AND Ni, THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES* (1985) (4)
Identification of proteins resembling G-protein alpha subunits in locust muscle. (1991) (4)
Properties of human erythrocyte Ns and Ni, the regulatory components of adenylate cyclase, as purified without regulatory ligands. (1985) (4)
Immunocytochemical localization of G-proteins (alpha subunits) in rat heart tissue. (1991) (4)
HMG-CoA-Reductase Inhibitors (Statins) (2007) (4)
Protein-protein interactions as new drug targets. Preface. (2008) (3)
Tissue distribution of beta 1- and beta 2-subunits of regulatory guanine nucleotide-binding proteins. (1989) (3)
Phosphorylation of G-protein alpha-subunits in intact adipose cells: evidence against a mediating role in insulin-dependent metabolic effects. (1989) (2)
Corrigendum to: The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues (2000) (2)
Structural and regulatory properties of nucleotide binding regulatory N proteins of adenylate cyclase and their effects on hormone receptors (1984) (2)
Signal Transduction and Ion Channel Activity (1990) (2)
Approaches to Studying the Interaction between G-Proteins and Voltage- Dependent Ca2+ Channels (1993) (1)
Identification of new protein-protein interactions of the endothelin B receptor (2005) (1)
Gs-activating receptors: modes of transmembrane signalling and genetic defects. (1993) (1)
[Bidirectional hormonal modulation of voltage dependent ca2+ channels]. (1989) (1)
Involvement of Pertussis Toxin-Sensitive G-Proteins in the Modulation of Voltage-Dependent Ca2+ Channels by Extracellular Signals (1989) (1)
Cyclic Amp-Mediated Aquaporin-2 Translocation: Identification of Protein Kinase a Anchoring Proteins and the Role of the Small GTPases of the Rho Family (2000) (1)
Involvement of pertussis-toxin-sensitive G-proteins in the modulation of Ca2+ channels by hormones and neurotransmitters (1993) (1)
Functional involvement of the SNARE machinery in cAMP-induced aquaporin-2 targeting to the apical plasma membrane in renal epithelial cells (2001) (1)
' s response to reviews Title : Multi-locus stepwise regression : an exhaustive haplotype-based algorithm for finding genetic associations applied to atopic dermatitis (2011) (0)
Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg (1990) (0)
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate. (1991) (0)
Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C (1988) (0)
Identification of G-Proteins Involved in the Inhibition of Ca2+ Currents in Neuronal and Endocrine Cells (1992) (0)
Functional involvement of ERM protein in AQP2 trafficking in renal cells (2003) (0)
Improved purification and characterization of membraneous and cytosolic inositol phospholipid-specific phospholipases C from porcine brain cortex. (1991) (0)
[Guanidine nucleotide binding proteins as membrane signal transduction components and regulators of enzymatic effectors]. (1988) (0)
Loss of pertussis toxin-sensitive G proteins from sarcolemma of ischaemic myocardium (1991) (0)
Diabetes Insipidus, Molecular Biology of (2006) (0)
A radiometric method for the determination of NADH in subpicomole amounts. (1988) (0)
Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells. (1998) (0)
New splice variant of a protein kinase A anchor protein and use of these (2003) (0)
Crucial Role of p38MAPK in Control of Aquaporin-2 Abundance in Renal Principal Cells (2010) (0)
Table of Contents (1988) (0)
Identification of proteins involved in the vasopressin-induced shuttle of aquaporin-2 (1999) (0)
Koenzym Q10 [Coenzyme Q10] (1997) (0)
Literature abstracts (2004) (0)
[Functional guanine nucleotide-binding proteins in receptor-mediated modulation of voltage-dependent ion channels]. (1988) (0)
Ca2+-Binding Proteins (2008) (0)
[Coenzyme Q10]. (1997) (0)
Correction: Actin remodeling requires ERM function to facilitate AQP2 apical targeting. (2021) (0)
Characterization ofGTP-binding proteins inGolgi-associated membrane vesicles fromratadipocytes (1992) (0)

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