Wayne Bowen
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American pharmacologist and biologist
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Wayne Bowen's Degrees
- PhD Pharmacology Cornell University
- Bachelors Biology Morgan State University
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Why Is Wayne Bowen Influential?
(Suggest an Edit or Addition)According to Wikipedia, Wayne Bowen is an American pharmacologist and biologist, currently the Upjohn University Professor of Pharmacology at Brown University.
Wayne Bowen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sigma receptors: biology and function. (1990) (818)
- A proposal for the classification of sigma binding sites. (1992) (706)
- Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. (1995) (475)
- Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling (1994) (361)
- A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain (1990) (358)
- Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. (1991) (278)
- Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. (2002) (245)
- Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism (1995) (234)
- Sigma receptors: recent advances and new clinical potentials. (2000) (231)
- Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. (2000) (187)
- Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs (1988) (185)
- Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling. (1994) (150)
- Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. (1990) (148)
- Evidence for a multi-site model of the rat brain σ receptor (1989) (134)
- Role of Sigma-1 Receptor C-terminal Segment in Inositol 1,4,5-Trisphosphate Receptor Activation (2008) (129)
- Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype. (1992) (128)
- Interconverting mu and delta forms of the opiate receptor in rat striatal patches. (1981) (127)
- Synthesis and evaluation of optically pure [3H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors (1989) (123)
- Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. (1992) (117)
- Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. (1995) (108)
- Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity (1999) (107)
- Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides (2002) (104)
- Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors. (1999) (103)
- A malignant melanoma imaging agent: synthesis, characterization, in vitro binding and biodistribution of iodine-125-(2-piperidinylaminoethyl)4-iodobenzamide. (1993) (102)
- σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain (1988) (101)
- ς1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward (2003) (95)
- Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats (1992) (91)
- Drug specificity of pharmacological dystonia (1990) (88)
- The sigma1 (σ1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming (2004) (79)
- Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. (1984) (76)
- Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. (2004) (76)
- σ2 Receptors regulate changes in sphingolipid levels in breast tumor cells (2002) (75)
- A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of sigma 2 receptors in motor function. (1993) (75)
- A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site. (1985) (75)
- Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine (1999) (74)
- Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons (1989) (74)
- Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study (1992) (73)
- Location of nicotinic and muscarinic cholinergic and μ-opiate receptors in rat cerebral neocortex: evidence from thalamic and cortical lesions (1992) (72)
- Sigma receptor-active neuroleptics are cytotoxic to C6 glioma cells in culture. (1993) (72)
- Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice. (2001) (71)
- Differential Effects of σ1 Receptor Blockade on Self-Administration and Conditioned Reinstatement Motivated by Cocaine vs Natural Reward (2007) (70)
- Signaling Pathways from Cannabinoid Receptor-1 Activation to Inhibition of N-Methyl-d-Aspartic Acid Mediated Calcium Influx and Neurotoxicity in Dorsal Root Ganglion Neurons (2009) (67)
- Affinity labeling of delta-opiate receptors using [D-Ala2,Leu5,Cys6]enkephalin. Covalent attachment via thiol-disulfide exchange. (1987) (66)
- Highly selective σ receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes (1998) (65)
- Ibogaine and its congeners are σ2 receptor-selective ligands with moderate affinity (1995) (64)
- Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters (2001) (63)
- Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. (1989) (63)
- Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells. (1994) (62)
- Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. (1992) (61)
- Differentiation of σ ligand‐activated receptor subtypes that modulate NMDA‐evoked [3H]‐noradrenaline release in rat hippocampal slices (1996) (61)
- Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. (1992) (59)
- N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice (2001) (59)
- Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: Evidence for a two-site allosteric model (1984) (56)
- Synthesis and Pharmacological Characterization of 4-[125I]-N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide: A High Affinity σ Receptor Ligand for Potential Imaging of Breast Cancer (1995) (55)
- Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands. (1991) (54)
- Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds. (1993) (54)
- Sigma receptors are expressed in human non-small cell lung carcinoma. (1995) (54)
- Ingestive behavior following central [D-Ala2, Leu5, Cys6]-Enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor (1991) (52)
- CB-64D and CB-184: ligands with high σ2 receptor affinity and subtype selectivity (1995) (49)
- Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1'-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer. (1999) (42)
- Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats (1995) (41)
- Synthesis and evaluation of [18F] labeled benzamides: high affinity sigma receptor ligands for PET imaging. (1997) (41)
- Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared to normal breast epithelial cells. (2003) (40)
- Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. (1999) (38)
- Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: selective actions at the deltanoncomplexed site. (1990) (37)
- Evidence for a multi-site model of the rat brain sigma receptor. (1989) (37)
- Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine. (1993) (37)
- Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. (1992) (37)
- Characterization of the enantiomers of cis-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)cyclohexylamine (BD737 and BD738): novel compounds with high affinity, selectivity and biological efficacy at sigma receptors. (1992) (36)
- Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. (1990) (36)
- Effect of β-FNA on opiate receptor binding: Preliminary evidence for two types of μ receptors (1983) (35)
- Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. (1999) (35)
- Synthesis, in vitro binding, and tissue distribution of radioiodinated 2-[125I]N-(N-benzylpiperidin-4-yl)-2-iodo benzamide, 2-[125I]BP: a potential sigma receptor marker for human prostate tumors. (1998) (34)
- Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. (1993) (34)
- Altered haloperidol-sensitive σ receptors in the genetically dystonic (dt) rat (1988) (34)
- Novel analogs of the σ receptor ligand BD1008 attenuate cocaine-induced toxicity in mice (2004) (33)
- N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. (2002) (31)
- Highly selective sigma receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes. (1998) (31)
- 3‘-Chloro-3α-(diphenylmethoxy)tropane But Not 4‘-Chloro-3α- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile† (1997) (31)
- sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. (2002) (29)
- Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors. (1989) (29)
- Characterization of a (+)-azidophenazocine-sensitive sigma receptor on splenic lymphocytes. (1993) (28)
- Ibogaine and its congeners are sigma 2 receptor-selective ligands with moderate affinity. (1995) (28)
- 99mTc-labeled sigma-receptor-binding complex: synthesis, characterization, and specific binding to human ductal breast carcinoma (T47D) cells. (1997) (27)
- μ-Opiate binding and morphine antagonism by octapeptide analogs of somatostatin (1987) (27)
- Down-regulation of sigma receptors by chronic haloperidol. (1990) (27)
- Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. (1999) (26)
- Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors. (1996) (26)
- Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. (1993) (26)
- 1,4-dibenzylpiperazines possess anticocaine activity. (2003) (26)
- Nigral 6-hydroxydopamine lesions equally decrease mu and delta opiate binding to striatal patches: further evidence for a conformationally malleable type 1 opiate receptor. (1982) (24)
- Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice. (1994) (24)
- Age-related differences in the sensitivity of rats to a selective sigma ligand (1989) (24)
- Substituted Halogenated Arylsulfonamides: A New Class of σ Receptor Binding Tumor Imaging Agents (1998) (24)
- N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice. (2001) (23)
- Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. (1999) (23)
- Acylation of σ receptors by Metaphit, an isothiocyanate derivative of phencyclidine (1989) (23)
- CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. (1995) (23)
- Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. (1997) (23)
- Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. (2003) (22)
- Adrenergic agents. 4. Substituted phenoxypropanolamine derivatives as potential beta-adrenergic agonists. (1977) (22)
- Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands. (1998) (22)
- Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. (2009) (21)
- Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. (1996) (21)
- [D-Ala2,Leu5,Cys6]enkephalin: Short-term agonist effects and long-term antagonism at delta opioid receptors (1989) (20)
- Structure–activity comparison of YZ-069, a novel σ ligand, and four analogs in receptor binding and behavioral studies (2004) (19)
- Distribution of opiate receptors within visual structures of the cat brain (2004) (19)
- A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes. (1994) (18)
- A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays. (2000) (18)
- Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity (2015) (18)
- Human antiidiotypic antibody against opiate receptors (1988) (18)
- Differential solubilization of rat liver σ1 and σ2 receptors: retention of σ2 sites in particulate fractions (1996) (17)
- The Effects of Sigma, PCP, and Opiate Receptor Ligands in Rats Trained With Ibogaine as a Discriminative Stimulus (1998) (17)
- Characterization of [3H] (+)-pentazocine, a highly selective sigma ligand. (1990) (17)
- Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives (2018) (17)
- Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. (2001) (16)
- Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain. (1988) (16)
- Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma (2016) (16)
- Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites. (1993) (16)
- Dissociation of the motor effects of (+)-pentazocine from binding to σ1 sites (1996) (15)
- Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions. (1996) (15)
- Sigma receptors and iboga alkaloids. (2001) (15)
- Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents. (1992) (14)
- Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans. (1995) (14)
- Sigma receptors and signal transduction: negative modulation of signaling through phosphoinositide-linked receptor systems. (1993) (14)
- Synthesis and pharmacological characterization of 4-[125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide: a high affinity sigma receptor ligand for potential imaging of breast cancer. (1995) (14)
- Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the delta non-complexed-opioid receptor. (1991) (14)
- Synthesis and characterization of [125I]3′-(−)-iodopentazocine, a selective σ1 receptor ligand (1997) (13)
- Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice. (2004) (13)
- Stress-induced tolerance to delta receptor agonist DPDPE and selectivity of the irreversible δ-ligand, DALCE (1990) (13)
- Design and Investigation of a [18F]-Labeled Benzamide Derivative as a High Affinity Dual Sigma Receptor Subtype Radioligand for Prostate Tumor Imaging. (2017) (12)
- (+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (sigma 1) site and quantitative structure-affinity relationship studies. (1995) (12)
- (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. (1995) (11)
- Investigation of the mechanism by which sigma ligands inhibit stimulation of phosphoinositide metabolism by muscarinic cholinergic agonists. (1990) (11)
- σ Binding parameters in developing rats predict behavioral efficacy of a σ ligand (1993) (11)
- Tritiated-6-beta-fluoro-6-desoxy-oxymorphone 〈[3H] FOXY〉: a new ligand and photoaffinity probe for the MU opioid receptors (1988) (11)
- Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity. (1996) (11)
- Characterization of type 2 opiate receptors. (1982) (10)
- A study of the effect of the irreversible delta receptor antagonist [d-Ala2,Leu5,Cys6]Enkephalin on δ cx and δ ncx opioid binding sites in vitro and in vivo (1992) (10)
- Chiral, potentially irreversible ligands for the sigma receptor based on the structure of 3-(3-hydroxyphenyl)-N-propylpideridine (3-PPP) (1992) (10)
- Evidence for intrinsic expression of enkephalin-like immunoreactivity and opioid binding sites in cat superior colliculus (1991) (9)
- [D-Ala2,(F5)Phe4]-dynorphin1–13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1–13 (1987) (9)
- Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes. (1988) (8)
- Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues. (1995) (7)
- Torticollis, midbrain, and sigma receptors. (1990) (7)
- Altered haloperidol-sensitive sigma receptors in the genetically dystonic (dt) rat. (1988) (6)
- Relationship between modulation of the cerebellorubrospinal system in the in vitro turtle brain and changes in motor behavior in rats: effects of novel sigma ligands (1999) (6)
- Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease (2020) (6)
- Biological Studies of Turmeric Oil, Part 2: Isolation and Characterization of Turmeric Oil Components; Cytotoxic Activity against Pancreatic Cancer Cells (2013) (6)
- Photoaffinity labeling of opiate receptors using intrinsically photoactive 3H-opiates. (1988) (6)
- Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands. (1999) (5)
- Wash-resistant inhibition of phencyclidine- and haloperidol-sensitive sigma receptor sites in guinea pig brain by putative affinity ligands: Determination of selectivity (1990) (5)
- Synthesis and Evaluation of Conformationally Restricted N‐(2‐(3,4‐ Dichlorophenyl)ethyl)‐N‐methyl‐2‐(1‐pyrrolidinyl)ethylamines at σ Receptors. Part 2. Piperazines, Bicyclic Amines, Bridged Bicyclic Amines, and Miscellaneous Compounds. (2010) (5)
- Microsomal enzymes of cholesterol biosynthesis from lanosterol: A progress report (1982) (5)
- 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. (1997) (5)
- Inhibition of cholinergic analgesia by (+)-opiates. (1990) (5)
- Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors. (1983) (5)
- Visualization and solubilization of rat brain opiate receptors with a “κ” ligand selectivity pattern (1982) (5)
- Synthesis and characterization of optically pure [3H](+)azidophenazocine ([3H](+)‐AZPH), a novel photoaffinity label for sigma receptors (1991) (4)
- Acylation of sigma receptors by Metaphit, an isothiocyanate derivative of phencyclidine. (1989) (4)
- Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites. (1996) (4)
- A novel stereo- and enantioselective synthesis of trans-9-alkyl-2-benzyl-5-methyl-6,7-benzomorphans (1994) (4)
- μ, δ AND κ OPIATE RECEPTORS: INTERCONVERTIBLE FORMS OF THE SAME RECEPTOR (1981) (3)
- Conformational malleability of opiate receptors: Sulfhydryl modification alters ion-inducedµ/δ-ligand selectivity shifts in rat striatal sections (1982) (3)
- Sigma binding parameters in developing rats predict behavioral efficacy of a sigma ligand. (1993) (3)
- A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo. (1992) (3)
- Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents. (1998) (3)
- Identification and characterization of MAM03055A: a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity. (2021) (3)
- Cytochrome P-450-dependent Oxidation of Lanosterol in Cholesterol Biosynthesis (2001) (3)
- Synthesis and σ Binding Properties of 2′-Substituted 5,9α- Dimethyl-6,7-benzomorphans. (1995) (3)
- σ2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics (2007) (2)
- Synthesis and σ Binding Properties of 1′‐ and 3′‐Halo‐ and 1′,3′‐ Dihalo‐N‐normetazocine Analogues. (1995) (2)
- Abstract 2559: Pharmacological characterization of sigma-2 receptor ligand-induced metabolic stimulation in human SK-N-SH neuroblastoma cells (2020) (2)
- A novel asymmetric synthesis of 3-benzyl-1,2,3,4,5,6-hexahydro-11-alkyl-2,6-methano-3-benzazocines (1994) (2)
- Sigma-i and Sigma-2 Receptors Are Expressed in a Wide Variety of Human and Rodent Tumor Cell Lines (2)
- Photoaffinity labeling of opiate receptors with 3H-etorphine: possible species differences in glycosylation. (1986) (2)
- Proceedings from the Fourth International Symposium on sigma-2 receptors: Role in health and disease (2022) (2)
- Sphingolipid biology and its role in cancer development and therapy (2016) (2)
- ADRENERGIC AGENTS. 4. SUBSTITUTED PHENOXYPROPANOLAMINE DERIVATIVES AS POTENTIAL β-ADRENERGIC AGONISTS (1977) (2)
- Sigma receptors as novel target structures for cancer chemotherapeutics (2008) (2)
- Novel kappa opioid receptor and sigma ligands. (1992) (2)
- Signaling pathways from CB1 receptor activation to inhibition of NMDA-mediated calcium influx and neurotoxicity in dorsal root ganglion neurons (2009) (2)
- Synthesis, Binding (Sigma Site) and Pharmacophore Model of N- Substituted N-Normetazocine and N-Nordeoxymetazocine Analogues. (1992) (1)
- N-(3,4-Dichlorobenzyl)azoles—Investigations Regarding Synthesis, NMR-Spectroscopy and Affinity Towards Sisma-1 and Sigma-2 Receptors (2004) (1)
- The effect of blocking the prosurvival AKT/P13K/mTOR and mutant KRAS-signaling pathways on chemotherapy resistance of pancreatic cancer. (2011) (1)
- Synthesis, Binding (Sigma Site) and Molecular Modeling Studies of N-Substituted N-Normetazocine and N-Nordeoxymetazocine Analogs: (1991) (1)
- Activation of sigma receptors results in down regulation of muscarinic cholinergic receptors (1990) (1)
- Abstract 2017: The role of ceramide in the dual cytotoxic and metabolic stimulative effects of sigma-2 receptors (2017) (1)
- Abstract B104: Liposomal C6 Ceramide appears to potentiate chemotoxicity of paclitaxel, gemcitabine and cetuximab against aggressive pancreatic cancer. (2013) (1)
- The competitive NMDA receptor antagonist, CPP, allosterically modulates NMDA receptor associated PCP binding sites in the absence of steric hinderance. (1990) (1)
- Abstract 2440: Evaluation of structural changes in SN79-derived sigma-2 receptor modulators: effect on apoptotic efficacy in SK-N-SH neuroblastoma (2015) (0)
- Abstract 221: C6-ceramide sensitizes the aggressive L3-6 pancreatic cancer cell line to paclitaxel-mediated antitumor effects in vivo and in vitro (2010) (0)
- Abstract 2242: Development of selective irreversible antagonists for sigma-2 receptors. (2013) (0)
- Abstract 4767: C6 ceramide sensitizes multiple aggressive pancreatic cancer cell lines to gemcitabine, paclitaxel and cetuximab mediated anti tumor effectsin vivoandin vitro (2011) (0)
- Abstract 1279: Sigma-2 receptor-mediated cell death is altered by cell density in human SK-N-SH neuroblastoma 2-D and 3-D cultures (2016) (0)
- Sigma 2-Agonist CB-64D Induces Apoptosis in Non Hodgkin’s Lymphoma Cells: Association with Decreased Akt Expression. (2004) (0)
- Decision letter: The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains (2021) (0)
- Synthesis, binding affinity (sigma, PCP, µ opioid), and molecular modeling study of (+)- and (-)-N-substituted N-normetazocine analogs (1991) (0)
- A Novel Asymmetric Synthesis of 3‐Benzyl‐1,2,3,4,5,6‐hexahydro‐11‐ alkyl‐2,6‐methano‐3‐benzazocines. (1995) (0)
- Radiolabeled monoclonal antibodies or their fragments (2006) (0)
- Letters to the editor (0)
- P-4-22 Haloperidol and reduced haloperidol discriminate sigma receptor subtypes in the neuronal response to N-methyl-D-aspartate in the rat hippocampus (1995) (0)
- Abstract 1699: Differential aggregation rates and therapeutic response of pancreatic cancer cell lines to sigma-2 receptor activation in 3D culture (2015) (0)
- Lack of irreversible antagonism of opioid & receptors by [D-ala2,Leu5,Cys6] enkephalin in the mouse isolated vas deferens preparation. (1990) (0)
- Effect of C6Ceramide on chemotoxicity of gemcitabine against chemoresistant pancreatic cell lines. (2015) (0)
- Affinity Labeling of & Opiate Receptors Using [ o-Ala 2 , Leu 5 , Cys 6 ] Enkephalin (2001) (0)
- A Novel Stereo- and Enantioselective Synthesis of trans-9-Alkyl-2- benzyl-5-methyl-6,7-benzomorphans. (1995) (0)
- Abstract 3797: C6Ceramide as potential novel therapy for pancreatic cancer (2015) (0)
- Characterization of D-Ala2,Leu5,Cys6-enkephalin: a novel synthetic opioid peptide with slowed dissociation from delta receptors. (1986) (0)
- Abstract 3237: Characterization of CM-572 and CM-769: Novel irreversible modulators of sigma-2 receptor function (2014) (0)
- Chiral, Potentially Irreversible Ligands for the σ Receptor Based on the Structure of 3-(3-Hydroxyphenyl)-N-propylpiperidine (3- PPP). (1993) (0)
- Abstract 3804: Structural changes to SN79 result in ligands that stimulate a metabolic function of sigma-2 receptors (2016) (0)
- The role of novel ligands in the biological characterization of sigma receptors (1996) (0)
- Identification of a novel class of highly potent sigma ligands related to the kappa-selective agonist U50,488. (1990) (0)
- Abstract 1671: Identification and characterization of MAM03055A, a novel bivalent sigma-2 receptor agonist (2018) (0)
- Abstract 600: Liposomal C6 ceramide appears to potentiate enhanced chemotoxicity of pancreatic cancer. (2013) (0)
- Synthesis and characterization of [125I]3'-(-)-iodopentazocine, a selective sigma 1 receptor ligand. (1996) (0)
- Abstract 1294: Differential sigma-2 receptor-mediated metabolic stimulative and apoptotic effects of monovalent CM571 and its homo-bivalent counterpart, MAM03055A (2019) (0)
- Interconverting ja and 6 forms of the opiate receptor in rat striatal patches (type 1 receptor pattern/divalent metal cations/sulfhydryl effectors/adenylate cyclase/autoradiography) (0)
- Comprar Sigma Receptors · Chemistry, Cell Biology and Clinical Implications | Matsumoto, Rae R. | 9780387365121 | Springer (2007) (0)
- Synthesis and Evaluation of Aryl-Substituted N-(Arylethyl)-N-methyl-2-( 1-pyrrolidinyl)ethylamines and Corresponding Arylacetamides for Sigma Receptor Affinity. (1996) (0)
- Abstract 5428: Sigma-2 receptor-induced cell death: a novel approach to triple-negative breast cancer treatment (2015) (0)
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