Wendell Lim

Q: What Schools Are Affiliated With Wendell Lim

Wendell Lim is affiliated with the following schools: University of California, Berkeley, Yale University, Eötvös Loránd University, Stanford University, Massachusetts Institute of Technology, University of California, San Francisco, Harvard University

Wendell Lim's AcademicInfluence.com Rankings

Wendell Lim

Biology

#3999

World Rank

#6031

Historical Rank

#1565

USA Rank

Biochemistry

#913

World Rank

#1021

Historical Rank

#236

USA Rank

biology Degrees

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Biology

Wendell Lim's Degrees

PhD Biochemistry Stanford University
Bachelors Biochemistry University of California, Berkeley

Why Is Wendell Lim Influential?

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According to Wikipedia, Wendell Lim is an American biochemist who is the Byer's Distinguished Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco. He is the director of the UCSF Cell Design Institute. He earned his A.B. in chemistry from Harvard University working with Jeremy Knowles on enzyme evolutionary optimization. He obtained his Ph.D in biochemistry and biophysics from Massachusetts Institute of Technology under the guidance of Bob Sauer using genetic and biophysical approaches to understand the role of hydrophobic core interactions in protein folding. He then did his postdoctoral work with Frederic Richards at Yale University on the structure of protein interaction domains. Lim's work has focused on cell signaling, synthetic biology, and cell engineering, particularly in immune cells.

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Wendell Lim's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (3736)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013) (2839)
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans (2008) (1032)
Spatiotemporal Control of Cell Signalling Using A Light-Switchable Protein Interaction (2009) (897)
CRISPR interference (CRISPRi) for sequence-specific control of gene expression (2013) (852)
Mechanism and role of PDZ domains in signaling complex assembly. (2001) (845)
Defining Network Topologies that Can Achieve Biochemical Adaptation (2009) (835)
Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information (2011) (784)
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds (2015) (783)
The Principles of Engineering Immune Cells to Treat Cancer (2017) (741)
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation (2015) (670)
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits (2016) (658)
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors (2016) (577)
PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain* (1999) (541)
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. (1999) (532)
Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. (2000) (517)
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor (2015) (513)
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. (2006) (475)
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells (2016) (465)
Deciphering the message in protein sequences: tolerance to amino acid substitutions. (1990) (461)
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains (1995) (441)
Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module (2013) (427)
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016) (424)
Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms (2003) (371)
Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs (2010) (368)
The Structure and Function of Proline Recognition Domains (2003) (365)
Systematic Functional Prioritization of Protein Posttranslational Modifications (2012) (364)
Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics (2008) (362)
Cell-Based Therapeutics: The Next Pillar of Medicine (2013) (351)
Alternative packing arrangements in the hydrophobic core of λrepresser (1989) (331)
Phosphotyrosine Signaling: Evolving a New Cellular Communication System (2010) (317)
Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. (1998) (303)
Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination (2003) (297)
The Ste5 Scaffold Allosterically Modulates Signaling Output of the Yeast Mating Pathway (2006) (276)
Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT (2003) (276)
Optimization of specificity in a cellular protein interaction network by negative selection (2003) (270)
Programming self-organizing multicellular structures with synthetic cell-cell signaling (2018) (265)
Designing customized cell signalling circuits (2010) (263)
Light-based feedback for controlling intracellular signaling dynamics (2011) (250)
Structure of the Enabled/VASP Homology 1 Domain–Peptide Complex A Key Component in the Spatial Control of Actin Assembly (1999) (246)
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. (2001) (234)
Complex transcriptional modulation with orthogonal and inducible dCas9 regulators (2016) (228)
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time (2011) (218)
Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species (2009) (204)
A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. (2005) (203)
Build life to understand it (2010) (200)
The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation (2009) (198)
Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. (2010) (194)
An analysis of packing in the protein folding problem (1993) (193)
Triosephosphate isomerase catalysis is diffusion controlled (1988) (191)
The role of internal packing interactions in determining the structure and stability of a protein. (1991) (189)
Improved Blue, Green, and Red Fluorescent Protein Tagging Vectors for S. cerevisiae (2013) (183)
Structure of the N-WASP EVH1 Domain-WIP Complex Insight into the Molecular Basis of Wiskott-Aldrich Syndrome (2002) (182)
Docking interactions in protein kinase and phosphatase networks. (2006) (178)
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (173)
Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory (2013) (173)
Secreting and Sensing the Same Molecule Allows Cells to Achieve Versatile Social Behaviors (2014) (171)
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function (2002) (167)
Designing Synthetic Regulatory Networks Capable of Self-Organizing Cell Polarization (2012) (164)
SYNZIP Protein Interaction Toolbox: in Vitro and in Vivo Specifications of Heterospecific Coiled-Coil Interaction Domains (2012) (161)
Design principles of regulatory networks: searching for the molecular algorithms of the cell. (2013) (158)
Rapid Diversification of Cell Signaling Phenotypes by Modular Domain Recombination (2010) (157)
Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci (2016) (157)
The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. (2005) (157)
Structural and energetic consequences of disruptive mutations in a protein core. (1992) (156)
Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. (1988) (155)
Converging on proline: the mechanism of WW domain peptide recognition (2000) (147)
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages (2008) (146)
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors (2007) (145)
Scaffolds: interaction platforms for cellular signalling circuits. (2009) (144)
The modular logic of signaling proteins: building allosteric switches from simple binding domains. (2002) (141)
Engineering synthetic signaling proteins with ultrasensitive input/output control (2007) (141)
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. (2004) (141)
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma (2021) (133)
An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis. (2001) (121)
Energetic determinants of internal motif recognition by PDZ domains. (2001) (120)
The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency (2008) (120)
Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Yeast and Immune Cells (2012) (117)
Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. (2017) (110)
The crystal structure of a mutant protein with altered but improved hydrophobic core packing. (1994) (110)
Improving SH3 domain ligand selectivity using a non-natural scaffold. (2000) (103)
Positive Selection of Tyrosine Loss in Metazoan Evolution (2009) (101)
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway (2018) (100)
Synthetic biology: lessons from the history of synthetic organic chemistry (2007) (100)
Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. (2004) (99)
Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition (1994) (97)
The first World Cell Race (2012) (95)
Alternative packing arrangements in the hydrophobic core of lambda repressor. (1989) (94)
Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation (2012) (93)
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains (1995) (89)
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal (2014) (84)
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. (2017) (81)
Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair (2012) (81)
CRISPR/Cas9 for Human Genome Engineering and Disease Research. (2016) (77)
Oscillatory stress stimulation uncovers an Achilles’ heel of the yeast MAPK signaling network (2015) (76)
Random mutagenesis of protein sequences using oligonucleotide cassettes. (1991) (74)
Precise T cell recognition programs designed by transcriptionally linking multiple receptors (2020) (64)
A microfluidic system for dynamic yeast cell imaging. (2008) (63)
T cell circuits that sense antigen density with an ultrasensitive threshold (2021) (62)
Signalling change: signal transduction through the decades (2013) (60)
Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem‐5 (1994) (59)
Modular engineering of cellular signaling proteins and networks. (2016) (58)
Engineering synthetic morphogen systems that can program multicellular patterning (2020) (58)
How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. (2002) (54)
Correction: Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species (2009) (53)
High-throughput multicolor optogenetics in microwell plates (2019) (52)
Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation (2014) (51)
Light control of plasma membrane recruitment using the Phy-PIF system. (2011) (51)
Role of electrostatic interactions in PDZ domain ligand recognition. (2003) (51)
Multiple WASP-interacting Protein Recognition Motifs Are Required for a Functional Interaction with N-WASP* (2007) (50)
β Strand Peptidomimetics as Potent PDZ Domain Ligands (2006) (50)
Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation (2013) (50)
Analysis of DNA-protein interactions by affinity coelectrophoresis. (1991) (49)
Differential genetic interactions of yeast stress response MAPK pathways (2015) (48)
Compactin inhibits insect HMG-CoA reductase and juvenile hormone biosynthesis. (1982) (48)
Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. (2017) (48)
A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. (2009) (47)
Cell signaling : principles and mechanisms (2015) (46)
Engineering dynamical control of cell fate switching using synthetic phospho-regulons (2016) (42)
Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase (2011) (38)
DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation (2020) (38)
Synthetic biology approaches to engineer T cells. (2015) (35)
The first World Cell Race (2013) (34)
Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies. (2020) (32)
Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit. (2017) (32)
Interrogating cellular perception and decision making with optogenetic tools (2017) (31)
Engineering cell-cell communication networks: programming multicellular behaviors. (2019) (30)
Engineering modular protein interaction switches by sequence overlap. (2007) (30)
Genetic sensor for strong methylating compounds. (2013) (29)
A General Model for Preferential Hetero-oligomerization of LIN-2/7 Domains (2005) (27)
Coordinated Folding and Association of the LIN-2, -7 (L27) Domain (2002) (26)
How Src exercises self-restraint (1997) (25)
Reading between the lines: SH3 recognition of an intact protein. (1996) (25)
T cells selectively filter oscillatory signals on the minutes timescale (2021) (25)
The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin (2010) (24)
The Design Principles of Biochemical Timers: Circuits That Discriminate Between Transient and Sustained Stimulation (2017) (22)
Cellular perception and misperception: Internal models for decision‐making shaped by evolutionary experience (2016) (19)
The genome of the choanoflagellate Monosiga brevicollis and the origins of metazoan multicellularity (2008) (19)
Mutational analysis of protein stability (1992) (18)
Synthetic development: learning to program multicellular self-organization (2019) (17)
Sending Mixed Messages for Cell Population Control (2014) (16)
Beta strand peptidomimetics as potent PDZ domain ligands. (2006) (15)
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression (2021) (15)
Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils (2013) (15)
Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution” (2011) (14)
Engineering cytokines and cytokine circuits (2020) (13)
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts (2016) (12)
Engineering T Cells to Treat Cancer: The Convergence of Immuno-Oncology and Synthetic Biology (2020) (12)
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution (2016) (11)
Is pigment patterning in fish skin determined by the Turing mechanism ? (10)
Synthetic cytokine circuits that drive T cell infiltration into immune-excluded tumors (2022) (10)
Reengineering the signaling properties of a Src family kinase. (2009) (9)
The double life of PX domains (2001) (9)
Conformational Control of the Ste 5 Scaffold Protein Insulates Against MAP Kinase (2013) (9)
From folding towards function (2002) (7)
BBF RFC 28: A method for combinatorial multi-part assembly based on the Type IIs restriction enzyme AarI (2009) (7)
Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning (2022) (6)
Programming multicellular assembly with synthetic cell adhesion molecules (2022) (6)
Good Information Scaffold Proteins : Hubs for Controlling the Flow of Cellular (2011) (5)
The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function (2022) (5)
Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains (2003) (5)
DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies (2019) (5)
Structure of the SH 3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding (2001) (5)
Simple Rules Determine Distinct Patterns of Branching Morphogenesis. (2019) (5)
Rethinking cancer targeting strategies in the era of smart cell therapeutics (2022) (5)
Resource Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (4)
Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma (2021) (3)
AN OBLIGATE HETERODIMERIZATION MODULE INVOLVED IN ASSEMBLY OF SIGNALING AND CELL POLARITY COMPLEXES (2002) (3)
Methods and compositions for RNA-directed target DNA modification and for RNA-directed transcription modulation (2013) (3)
Cell biology 2.0. (2012) (3)
Short ArticleSho 1 and Pbs 2 Act as Coscaffolds Linking Components in the Yeast High Osmolarity MAP (2004) (2)
Modular Recombination Reprogramming Control of an Allosteric Signaling Switch Through (2014) (2)
Bio Building Basics : A Conceptual Instruction Manual for Synthetic Biology (2007) (2)
MAP Kinase Misactivation Conformational Control of the Ste 5 Scaffold Protein Insulates Against (2012) (1)
Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning (2022) (1)
Resource Systematic Functional Prioritization of Protein Posttranslational Modifications (2012) (1)
Brief Communication b Strand Peptidomimetics as Potent PDZ Domain Ligands (2006) (1)
SH3-Guanylate Kinase Module from PSD-95 (2002) (1)
Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue (2018) (1)
A Light-Based Feedback Control System for Generating User-Defined Intracelullar Signaling Dynamics (2012) (1)
Design of Tunable Oscillatory Dynamics in a Synthetic NFk B Signaling Circuit Graphical (2017) (0)
Crystal structure of Fus3 phosphorylated on Tyr182 (2006) (0)
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells (2017) (0)
The engineering principles of cellular control and movement systems (2006) (0)
Frederic M Richards 1925–2009 (2009) (0)
What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? (2020) (0)
EXTH-33. PRIMING OF SYNNOTCH CAR T CELLS VIA CNS-SPECIFIC ANTIGEN ALLOWS SPATIAL AND TEMPORAL REGULATION OF CAR EXPRESSION, EFFECTIVE HOMING AND PERSISTENCE OF T CELLS IN THE CNS (2022) (0)
Bridging cross-cultural gaps in scientific exchange through innovative team challenge workshops (2013) (0)
NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins (2005) (0)
IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA (2020) (0)
Analysis of Differentially Expressed Genes Fundamental in the Suspended Animation of Non-hibernating Mice (2014) (0)
Materials and Methods (1999) (0)
Metazoan Evolution ' ' Response to Comment on ' ' Positive Selection of Tyrosine Loss in (2012) (0)
Trends in Biological Physics: Synthetic Biology (2015) (0)
Methods and compositions for modifying target DNA directed RNA and modulation of transcription directed RNA (2013) (0)
Instructional materials that control cellular activity through synthetic Notch receptors. (2023) (0)
Crystal structure of non-phosphorylated Fus3 (2006) (0)
Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells (2019) (0)
Engineered Lymphocytes Expressing Mutant Form of TGFβ Block TGFβ Pathway on Lung Fibroblasts (2019) (0)
Abstract A031: Engineering antigen density sensors for T-cell immunotherapy (2019) (0)
The Modular Logic of Cell Signaling Systems (2006) (0)
Structure of the 'minimal scaffold' (ms) domain of Ste5 that cocatalyzes Fus3 phosphorylation by Ste7 (2009) (0)
IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION (2018) (0)
Author response: Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (0)
Probing Molecular Number Variability in Intracellular Structures using Photoswitchable Fluorescent Proteins (2013) (0)
Short Article Sho1 and Pbs2 Act as Coscaffolds Linking Components in the Yeast High Osmolarity MAP Kinase Pathway (2004) (0)
Principles of Systems Biology, No. 11. (2016) (0)
WHO WE ARE (2020) (0)
SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR (1999) (0)
EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE (1999) (0)
Crystal structure of Fus3 without a peptide from Ste5 (2006) (0)
Harnessing synthetic biology to engineer organoids and tissues. (2023) (0)
The Design Logic of Cell Signaling Systems (2010) (0)
The role of hydrophobic core in protein folding (1991) (0)
Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem-5 (2002) (0)
DNA-scaffolded biomaterials enable modular and tunable presentation of proteins to control immune cell therapies (2020) (0)
Signaling Mechanisms of Proteins and Protein Complexes (2015) (0)
Protein Dynamism and Evolvability (2009) (0)
IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION (2019) (0)
High-throughput multicolor optogenetics for the systematic manipulation of cell behavior (2019) (0)
Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin (2012) (0)
Wingless virgin queens assume helper roles in Acromyrmex leaf-cutting ants (2012) (0)
Engineering circuits for temporal control (2009) (0)
Crystal structure of Fus3 with a docking motif from Far1 (2006) (0)
Structure of the minimal Ste5 VWA domain subject to autoinhibition by the Ste5 PH domain (2012) (0)
Precise control of immune modulation using DNA scaffold-mediated biomaterial functionalization (2021) (0)

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What Schools Are Affiliated With Wendell Lim?

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