Werner Arber | Academic Influence

Why Is Werner Arber Influential?

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Areas of Specialization: Microbiology
Werner Arber is a geneticist and microbiologist. He studied at the Swiss Federal Institute of Technology and the University of Geneva. His doctorate was completed at the University of Geneva, where he studied electron microscopy and lambda bacteriophages.

Arber has worked with students, scientists and researchers at the University of Southern California, the University of Geneva, the University of California, Berkeley and the University of Basel.

He was among the first to work in the University of Basel’s new interdisciplinary research center, the Biozentrum. His work on restriction endonucleases (and arguably his experience working with Daisy Roulland-Dussoix, a PhD student) led to a shared Nobel Prize in Physiology or Medicine.

He has provided exceptional scientific leadership, serving as a member of the World Knowledge Dialogue Scientific Board and the Pontifical Academy of Sciences. In 2011, he became the first protestant to be appointed as President of the Pontifical Academy of Sciences. He is co-founder of the World Cultural Council and a fellow of the American Academy of Arts and Sciences.

Arber has been generous with his time, sharing his expertise and knowledge with future scientists through the Lindau Nobel Laureate Meetings. Through these interactions, he is able to mentor young scientists and nurture a spirit of inquiry and deep curiosity.

Featured in Top Influential Biologists Today

According to Wikipedia, Werner Arber is a Swiss microbiologist and geneticist. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. Their work would lead to the development of recombinant DNA technology.

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Werner Arber's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

DNA modification and restriction. (1969) (563)
Host specificity of DNA produced by Escherichia coli. 9. Host-controlled modification of bacteriophage fd. (1966) (361)
Genetic variation: molecular mechanisms and impact on microbial evolution. (2000) (284)
Genomic evolution during a 10,000-generation experiment with bacteria. (1999) (267)
Host specificity of DNA produced by Escherichia coli. II. Control over acceptance of DNA from infecting phage lambda. (1962) (205)
Transduction of chromosomal genes and episomes in Escherichia coli. (1960) (189)
Host-Controlled Modification of Bacteriophage (1965) (177)
Experimental Methods for Use with Lambda (1983) (176)
Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form. (1962) (173)
Host specificity of DNA produced by Escherichia coli (1964) (172)
Electron microscopical studies of phage multiplication. I. A method for quantitative analysis of particle suspensions. (1957) (165)
Insertion sequence-related genetic variation in resting Escherichia coli K-12. (1994) (145)
Genetic manipulation : impact on man and society (1984) (138)
Nucleotide sequence of IS26, a new prokaryotic mobile genetic element. (1983) (131)
CHAPTER 4 – Prokaryotic IS Elements (1983) (119)
Mutational analysis of a prokaryotic recombinational enhancer element with two functions. (1989) (113)
Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of bacteriophage lambda. (1962) (111)
HOST SPECIFICITY OF DNA PRODUCED BY Escherichia coli, XI. In vitro MODIFICATION OF PHAGE FD REPLICATIVE FORM (1968) (107)
Host-controlled modification of bacteriophage. (1963) (103)
HOST SPECIFICITY OF DNA PRODUCED BY ESCHERICHIA COLI V . THE ROLE OF METHIONINE IN THE PRODUCTION OF HOST SPECIFICITY. (1965) (103)
Dynamics of IS-related genetic rearrangements in resting Escherichia coli K-12. (1995) (98)
A site‐specific, conservative recombination system carried by bacteriophage P1. Mapping the recombinase gene cin and the cross‐over sites cix for the inversion of the C segment. (1982) (89)
Host specificity of DNA produced by Escherichia coli. XV. The role of nucleotide methylation in in vitro B-specific modification. (1972) (85)
DNA modification and restriction. (1974) (80)
DNA restriction--modification genes of phage P1 and plasmid p15B. Structure and in vitro transcription. (1983) (79)
Two DNA antirestriction systems of bacteriophage P1, darA, and darB: characterization of darA- phages. (1987) (79)
Nucleotide sequence of the prokaryotic mobile genetic element IS30. (1984) (78)
Horizontal Gene Transfer among Bacteria and Its Role in Biological Evolution (2014) (76)
Rearrangements of genetic material in Escherichia coli as observed on the bacteriophage P1 plasmid. (1979) (74)
An Escherichia coli mutant which inhibits the injection of phage λ DNA (1974) (73)
Phage λ DNA injection into Escherichia coli pel− mutants is restored by mutations in phage genes V or H (1976) (64)
Evolution of prokaryotic genomes. (1993) (58)
DNA inversion regions Min of plasmid p15B and Cin of bacteriophage P1: evolution of bacteriophage tail fiber genes (1992) (58)
TEMPERATURE-SENSITIVE MUTANTS OF COLIPHAGE LAMBDA. (1964) (57)
Promotion and limitation of genetic exchange. (1979) (56)
Polylysogeny for Bacteriophage Lambda. (1960) (55)
Host specificity of DNA produced by Escherichia coli. XII. The two restriction and modification systems of strain 15T-. (1970) (52)
Functional characterization of the prokaryotic mobile genetic element IS26 (2004) (52)
Site-specific DNA inversion is enhanced by a DNA sequence element in cis. (1985) (50)
Three functions of bacteriophage P1 involved in cell lysis (1996) (50)
Terminal inverted repeats of insertion sequence IS30 serve as targets for transposition (1997) (49)
The insertion element IS1 is a natural constituent of coliphage P1 DNA. (1978) (49)
Elements for a theory of molecular evolution. (2003) (47)
HOST SPECIFICITY OF DNA PRODUCED BY ESCHERICHIA COLI. IV. HOST SPECIFICITY OF INFECTIOUS DNA FROM BACTERIOPHAGE LAMBDA. (1965) (44)
The N-terminal domain of the insertion sequence 30 transposase interacts specifically with the terminal inverted repeats of the element. (1990) (44)
Plaque-forming transducing bacteriophage P1 derivatives and their behaviour in lysogenic conditions. (1976) (42)
Genesis and natural history of IS-mediated transposons. (1981) (40)
E. coli K-12 pel mutants, which block phage λ DNA injection, coincide with ptsM, which determines a component of a sugar transport system (1978) (40)
Physical mapping of BglII, BamHI, EcoRI, HindIII and PstI Restriction fragments of bacteriophage P1 DNA (1977) (40)
Target specificity of insertion element IS30 (1998) (39)
IS2 insertion is a major cause of spontaneous mutagenesis of the bacteriophage P1: non‐random distribution of target sites. (1983) (39)
Gene organization and target specificity of the prokaryotic mobile genetic element IS26 (2004) (39)
The kanamycin resistance transposon Tn2680 derived from the R plasmid Rts1 and carried by phage P1Km has flanking 0.8-kb-long direct repeats. (1982) (38)
Bent DNA is needed for recombinational enhancer activity in the site-specific recombination system Cin of bacteriophage P1. The role of FIS protein. (1989) (38)
Erweiterung des Wirtsbereiches des Bakteriophagen λauf Escherichia coli B (1961) (37)
Formation of the tandem repeat (IS30)2 and its role in IS30-mediated transpositional DNA rearrangements (1993) (36)
Genetic engineering compared to natural genetic variations. (2010) (35)
Elements in microbial evolution (1991) (35)
Die Struktur des Schwanzes der Phagen T2 und T4 und der Mechanismus der irreversiblen Adsorption (1955) (33)
Bleomycin-resistance gene derived from the transposon Tn5 confers selective advantage to Escherichia coli K-12. (1991) (33)
An Antisense RNA in IS30 Regulates the Translational Expression of the Transposase (1997) (32)
Host specificity of DNA produced by Escherichia coli (1965) (31)
Promotion of RNA transcription on the insertion element IS30 of E. coli K12. (1985) (30)
Terminal inverted repeats of prokaryotic transposable element IS186 which can generate duplications of variable length at an identical target sequence. (1986) (29)
Study of the properties of seven defective-lysogenic strains derived from Escherichia coli K12 (lambda). (1958) (29)
Accessory genes in the darA operon of bacteriophage P1 affect antirestriction function, generalized transduction, head morphogenesis, and host cell lysis. (1998) (29)
The sequence of the bacteriophage P1 genome region serving as hot target for IS2 insertion. (1983) (28)
Plaque forming specialized transducing phage P1: Isolation of P1CmSmSu, a precursor of P1Cm (1977) (28)
Vector for IS element entrapment and functional characterization based on turning on expression of distal promoterless genes. (1996) (27)
Transposable element IS1 intrinsically generates target duplications of variable length. (1985) (26)
Is the IS1-flanked r-determinant of the R plasmid NR1 a transposon? (1981) (26)
Does the insertion element IS1 transpose preferentially into A+T-rich DNA segments? (2004) (24)
The bacteriophage P1 site-specific recombinase cin: recombination events and DNA recognition sequences. (1984) (24)
Characterization of in vitro constructed IS30-flanked transposons. (1989) (23)
Generation of genetic diversity by DNA rearrangements in resting bacteria (1994) (23)
Bacteriophage P1 gene 10 encodes a trans-activating factor required for late gene expression (1991) (22)
The Min DNA inversion enzyme of plasmid p15B of Escherichia coli 15T−: a new member of the Din family of site‐specific recombinases (1990) (22)
Site-specific DNA recombination system Min of plasmid p15B: a cluster of overlapping invertible DNA segments. (1990) (22)
IS30, a new insertion sequence of Escherichia coli K12 (2004) (22)
Promotion and limitation of genetic exchange (1979) (22)
The generation of variation in bacterial genomes (2004) (21)
APPENDIX I Spontaneous Mutations in the Escherichia coli Prophage P1 and IS-Mediated Processes (1981) (21)
A Beginner’s Guide to Lambda Biology (1983) (21)
An Escherichia coli mutant which inhibits the injection of phage lambda DNA. (1974) (21)
Host specificity of DNA produced by Escherichia coli. XIV. The role of nucleotide methylation in in vivo B-specific modification. (1972) (21)
Genetic Variation and Molecular Evolution (2006) (20)
Occurrence and properties of composite transposon Tn2672: evolution of multiple drug resistance transposons (1982) (19)
[Mutational loss of the B-specific restriction in bacteriophage fd]. (1967) (19)
Sequence relations among the IncY plasmid p15B, P1, and P7 prophages. (1986) (19)
The Major Histocompatibility Antigens in Various Species (1970) (18)
Gene organization in the multiple DNA inversion region min of plasmid p15B of E.coli 15T-: assemblage of a variable gene. (1991) (17)
Phage lambda DNA injection into Escherichia coli pel- mutants is restored by mutations in phage genes V or H. (1976) (17)
Mechanisms in microbial evolution. (1990) (17)
Involvement of Gene Products in Bacterial Evolution (1999) (16)
Bacteriophage P1 tail-fibre and dar operons are expressed from homologous phage-specific late promoter sequences. (1989) (16)
ON THE HOST-CONTROLLED MODIFICATION OF BACTERIOPHAGE LAMBDA. (1963) (16)
Mutational analysis of the bacteriophage P1 late promoter sequence Ps. (1992) (16)
Host specificity of DNA produced by Escherichia coli. 8. Its acquisition by phage lambda and its persistence through consecutive growth cycles. (1966) (15)
Host-controlled restriction and modification of filamentous 1- and F-specific bacteriophages. (1969) (15)
Physical analysis of the genomes of hybrid phages between phage P1 and plasmid p15B. (1983) (15)
Biological evolution: lessons to be learned from microbial population biology and genetics. (2004) (15)
On the segregation of IS1-mediated cointegrates between bacteriophage P1 DNA and plasmid pBR322 derivatives (1982) (15)
The characterization of terminators of RNA transcription on IS30 and an analysis of their role in IS element-mediated polarity. (1986) (14)
On the role of IS1 in the formation of hybrids between the bacteriophage P1 and the R plasmid NR1 (2004) (14)
A cloned DNA fragment from bacteriophage P1 enhances IS2 insertion (1987) (14)
Parental fd DNA is efficiently transferred into progeny bacteriophage particles even at low multiplicity of infection. (1969) (12)
Tn5‐mediated bleomycin resistance in Escherichia coli requires the expression of host genes (1993) (12)
A transcriptional terminator sequence in the prokaryotic transposable element IS1 (1987) (12)
Bacteriophage P1 gene 10 is expressed from a promoter-operator sequence controlled by C1 and Bof proteins (1992) (12)
The impact of science and technology on the civilization. (2009) (12)
Roots, strategies and prospects of functional genomics (2002) (11)
Random mutagenesis using degenerate oligodeoxyribonucleotides. (1988) (11)
Cointegrates between bacteriophage P1 DNA and plasmid pBR322 derivatives suggest molecular mechanisms for P1-mediated transduction of small plasmids (2004) (11)
Organization of the bacteriophage P1 tail-fibre operon. (1989) (11)
Mutations in the carboxy‐terminal part of IS30 transposase affect the formation and dissolution of (IS30)2 dimer (1997) (10)
Multiple physical differences in the genome structure of functionally related bacteriophages P1 and P7 (1979) (10)
Biodiversity as a source for synthetic domestication of useful specific traits (2013) (10)
Bacteriophage P1 derivatives unaffected in their growth by a large inversion or by IS insertions at various locations. (1985) (9)
The evolutionary strategy of DNA acquisition as a possible reason for a universal genetic code. (2006) (9)
Molecular mechanisms driving Darwinian evolution (2008) (8)
Restriction endonucleases. (1978) (8)
Morphologie von Leberglykogen (1957) (8)
Chapter 4 Host-controlled Variation (1971) (8)
On the Role of IS 1 in the Formation of Hybrids between the Bacteriophage P 1 and the R Plasmid NR 1 (8)
Molecular Darwinism: The Contingency of Spontaneous Genetic Variation (2011) (8)
Dual Nature of the Genome: Genes for the Individual Life and Genes for the Evolutionary Progress of the Population (2005) (7)
Cin-mediated recombination at secondary crossover sites on the Escherichia coli chromosome (1995) (7)
Amplification of drug resistance genes flanked by inversely repeated IS1 elements: involvement of IS1-promoted DNA rearrangements before amplification (1987) (7)
Bacterial "inserted sequence" elements and their influence on genetic stability and evolution. (1983) (7)
DNA restriction-modification enzymes of phage P1 and plasmid p15B (1983) (7)
APPENDIX II Analysis of Transposition of IS1-kan and Its Relatives (1981) (7)
Lack of hotspot targets: a constraint for IS30 transposition in Salmonella. (1999) (6)
Gene products with evolutionary functions (2005) (6)
Evolutionary relevance of genetic rearrangements involving plasmids. (1985) (6)
Evolution of prokaryotic genomes. (2002) (6)
HOST SPECIFICITY OF DNA PRODUCED BY ESCHERICHIA COLI. 3. EFFECTS ON TRANSDUCTION MEDIATED BY LAMBDA DG. (1964) (5)
Genome fusion mediated by the site specific DNA inversion system of bacteriophage P1 (2004) (4)
Systemic aspects of biological evolution. (2009) (4)
What is the function of DNA restriction enzymes (1977) (4)
Crossover sites cix for inversion of the invertible DNA segment C on the bacteriophage P7 genome. (1985) (4)
An active variant of the prokaryotic transposable element IS903 carries an amber stop codon in the middle of an open reading frame (2004) (4)
Towards a Sustainable Use of Natural Resources by Respecting the Laws of Nature (2016) (4)
Genetic Variation and Molecular Darwinism (2011) (4)
MOLECULAR EVOLUTION: COMPARISON OF NATURAL AND ENGINEERED GENETIC VARIATIONS (2013) (4)
Mechanisms involved in the formation of plaque-forming derivatives from over-sized hybrid phages between bacteriophage P1 and the R plasmid NR1 (1987) (3)
Société Suisse de Microbiologie/ Schweizerische Mikrobiologische Gesellschaft (1952) (3)
Genetic engineering represents a safe approach for innovations improving nutritional contents of major food crops (2017) (3)
Host specificity of DNA produced byEscherichia coli (1966) (2)
The Scientific Legacy of the 20th Century : the Proceedings of the Plenary Session, 28 October – 1 November, 2010 (2011) (2)
[Origin and properties of type A host specificity in Escherichia coli]. (1969) (2)
On the Origin of Genetic Diversity (1995) (2)
Host specificity of DNA produced by Escherichia coli. XVI. Phage lambda DNA carries a single site of affinity for A-specific restriction and modification. (1972) (2)
Host specificity of DNA produced by Escherichia coli. 13. Breakdown of cellular DNA upon growth in ethionine of strains with r plus-15, r plus-P1 or r plus-N3 restriction phenotypes. (1970) (2)
Involvement of transposable elements in the formation of hybrid phages between bacteriophage P1 and the R plasmid NR1 (1987) (1)
[Enlargement of the host area of bacteriophage lambda for Escherichia coli B]. (1961) (1)
Erratum: Host Specificity of DNA Produced by Escherichia coli (1970) (1)
[Defectiveness of lambda phage transductor]. (1957) (1)
[THE ROLE OF DNA METHYLATION IN THE CONTROL MY THE HOST OF MODIFICATION OF THE BACTERIOPHAGE]. (1965) (1)
Plaque-Forming Recombinants between Bacteriophage P1 and R factor NR1 and their Behaviour in Lysogenic Conditions (1974) (1)
[Research on the fine structure of a bacteriophage with the help of oxydative decomposition]. (1955) (1)
Evolutionary Interplay Between Spontaneous Mutation and Selection: Aleatoric Contributions of Molecular Reaction Mechanisms (1994) (1)
Contemplations on genes and biological functions. (1991) (1)
Restriction Enzymes: From Their Discovery to Their Applications (2012) (1)
Diversity of Life in a Changing World (1995) (1)
[Not all risks of medical progress and biological basic research are predictable]. (1980) (1)
STOCHASTIC GENETIC VARIATIONS AND THEIR ROLE IN BIOLOGICAL EVOLUTION (2013) (1)
The 2009 Lindau Nobel Laureate Meeting: Werner Arber, Physiology or Medicine 1978 (2010) (1)
Genetically encoded generators of genetic variants. (2009) (1)
"Investing in Science, Technology and Innovation: Challenges and Opportunities for Parliaments" (2007) (1)
Current Topics in Microbiology and Immunology (1981) (0)
[Factors of antibiotic resistance. Viewpoint of the molecular geneticist]. (1967) (0)
Microbiology: impact on research in life sciences. (2001) (0)
Today’s molecular biological research. (2010) (0)
THE IMPACT OF MICROBIAL GENETICS ON THE DEVELOPMENT OF GENOMICS AND BIOTECHNOLOGY (2013) (0)
Transdisciplinarity in Science Education and in Science Communication (2020) (0)
Molecular Darwinism and its Relevance for Translational Genetic Research (2011) (0)
DNA inversion mediated by the r-determinant of plasmid NR1: Evidence for the intramolecular replicative transposition of a 23 kb IS1-flanked transposon? (1986) (0)
FROM MICROBIAL GENETICS TO MOLECULAR DARWINISM AND BEYOND (2013) (0)
Concluding Remarks (1999) (0)
In vitro Modifikation der replikativen Form des Bakteriophagen fd (1969) (0)
Buchbesprechungen-BookReviews-LivresNouveaux (1951) (0)
Structures of oversized genomes of phage P1 derivatives carrying lac genes of Escherichia coli K12 (1987) (0)
[Biological specificities of desoxyribonucleic acid]. (1962) (0)
Referees 1997 (1997) (0)
Roots, promotion and impact of technological innovation (2008) (0)
The Proceedings of the Plenary Session on Predictability in Science: Accuracy and Limitations: 3-6 November 2006 (2008) (0)
Letter from Werner Arber to Esther Lederberg (1958) (0)
Report of the CGIAR Science Partnership Committee (2001) (0)
Index autorum ad Vol. XXX (1967) (0)
Insight into the natural potency to evolve, can indicate safe procedures for genetic engineering (2012) (0)
Nobel Laureate's views on higher education (2006) (0)
ASYMMETRIC HYDROFORMYLATION OF OLEFINIC HYDROCARBONS BY PLATINUM CATALYSTS (1978) (0)
Host-Controlled Modification of DNA (1968) (0)
Letter from Werner Arber to Joshua Lederberg (1959) (0)
Letter from Werner Arber to Joshua and Esther Lederberg (1958) (0)
Research letterStructures of oversized genomes of phage P1 derivatives carrying lac genes of Escherichia coli K12 (1987) (0)
Self-Organization of the Biological Evolution (2019) (0)
DNA fingerprinting. (2020) (0)
Natural Strategies of Spontaneous Genetic Variation: The Driving Force of Biological Evolution (2018) (0)
Closing Session: Future Directions: Strategies and Perspectives (1999) (0)
Reversion of a truncated gene for ampicillin resistance by genetic rearrangements in Escherichia coli K12 (2004) (0)
Stability and alteration of insertion sequence IS1-mediated chloramphenicol transposons (1981) (0)
Letter from Werner and Silvia Arber to Joshua Lederberg (1978) (0)
Index reriim ad Vol. XXX (1967) (0)
Complexity and Analogy in Science : Theoretical, Methodological and Epistemological Aspects ; The Proceedings of the Plenary Session, 5-7 November 2012 (2015) (0)
Natural mechanisms of interspecific gene transfer (1987) (0)
3 The theory of molecular evolution and its medical implications (2005) (0)
Bioengineering at the Interface between Science and Society (2011) (0)
Incompatibilities and Restrictions in Plasmid Transmission (2008) (0)
Normal expression of the viral gene N interferes with growth of bacteriophage λ in Escherichia coli 15T- (1977) (0)
[In vitro modification of the replicative form of fd bacteriophage]. (1969) (0)
Mitglieder-Liste der Schweizerischen Mikrobiologischen Gesellschaft (1951) (0)
Ernst Wïesmann zum 60. Geburtstag (1969) (0)
Untersuchung der Feinstruktur eines Bakteriophagen mit Hilfe von oxydativem Abbau (1955) (0)
Human-Nature Co-Evolution (2014) (0)
Schweizerische Mikrobiologische Gesellschaft/ Société Suisse de Microbiologie (2004) (0)
Complexity of Life and Its Dependence on the Environment (2020) (0)
Book Review – Buchbesprechung – Livre nouveau (1974) (0)
Transduction By P1 of Gal and Lp Regions From Heterogenotic Donors (1959) (0)
Ursprung und Eigenschaften des Wirtsspezifittstypus A in Escherichia coli (1969) (0)
NUCLEOTIDE SEQUENCE SPECIFICITY OF RESTRICTION ENDONUCLEASES (1999) (0)
Normal expression of the viral gene N interferes with growth of bacteriophage lambda in Escherichia coli 15T-. (1977) (0)

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