Wilfred van der Donk
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Dutch-American enzymologist and chemical biologist
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Wilfred van der Donkchemistry Degrees
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Wilfred van der Donkbiology Degrees
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Chemistry Biology
Wilfred van der Donk's Degrees
- PhD Chemistry University of Groningen
- Masters Chemistry University of Groningen
Why Is Wilfred van der Donk Influential?
(Suggest an Edit or Addition)According to Wikipedia, Wilfred A. van der Donk is a Dutch–American enzymologist and chemical biologist. He is the Richard E. Heckert Chair in Chemistry at the University of Illinois Urbana-Champaign. Early life and education van der Donk was born on April 21, 1966, and raised in Culemborg, Netherlands, where he remained to earn his bachelor's degree and master's degree in inorganic chemistry at Leiden University. Following this, he moved to the United States for his PhD at Rice University with Kevin Burgess. Upon graduating in 1994, he completed his postdoctoral work at the Massachusetts Institute of Technology.
Wilfred van der Donk's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. (2013) (1360)
- Protein Radicals in Enzyme Catalysis. (1998) (1126)
- Biosynthesis and mode of action of lantibiotics. (2005) (607)
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Lantibiotics: peptides of diverse structure and function. (2007) (582)
- Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease (2019) (365)
- Follow the leader: the use of leader peptides to guide natural product biosynthesis. (2010) (349)
- Recent developments in pyridine nucleotide regeneration. (2003) (332)
- Regeneration of cofactors for use in biocatalysis. (2003) (318)
- Discovery, biosynthesis, and engineering of lantipeptides. (2012) (297)
- Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes (2017) (261)
- Biosynthesis of phosphonic and phosphinic acid natural products. (2009) (260)
- Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis (2006) (256)
- Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean (2012) (244)
- Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic (2006) (229)
- Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB (2014) (228)
- Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria (2010) (228)
- Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity (2004) (227)
- New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products. (2016) (204)
- Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS (2011) (181)
- Sublancin is not a lantibiotic but an S-linked glycopeptide (2011) (181)
- Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights (2010) (176)
- New developments in RiPP discovery, enzymology and engineering. (2020) (175)
- Synthesis of a selenocysteine-containing peptide by native chemical ligation. (2001) (164)
- Genome mining for ribosomally synthesized natural products. (2011) (161)
- The cyclooxygenase reaction mechanism. (2002) (147)
- Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. (2003) (144)
- Evolution of lanthipeptide synthetases (2012) (142)
- Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes (2015) (140)
- Production of Lantipeptides in Escherichia coli (2010) (138)
- In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin (2015) (128)
- Facile chemoselective synthesis of dehydroalanine-containing peptides. (2000) (125)
- Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era. (2017) (120)
- Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin (2009) (117)
- Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. (2005) (116)
- Lantibiotics from Geobacillus thermodenitrificans (2012) (112)
- Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. (2002) (109)
- Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. (2007) (107)
- Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. (2013) (107)
- An Unusual Carbon-Carbon Bond Cleavage Reaction During Phosphinothricin Biosynthesis (2009) (100)
- Substrate activation by iron superoxo intermediates. (2010) (98)
- New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. (2007) (98)
- Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. (2006) (97)
- In vitro activity of the nisin dehydratase NisB (2013) (97)
- Nine Post-translational Modifications during the Biosynthesis of Cinnamycin (2011) (94)
- Mechanism of Inhibition of Bacillus anthracis Spore Outgrowth by the Lantibiotic Nisin (2011) (92)
- A lanthipeptide library used to identify a protein–protein interaction inhibitor (2017) (91)
- An engineered azurin variant containing a selenocysteine copper ligand. (2002) (89)
- In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids (2009) (88)
- Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. (2010) (87)
- Structural Characterization of Four Prochlorosins: A Novel Class of Lantipeptides Produced by Planktonic Marine Cyanobacteria (2012) (87)
- Heterologous Expression, Purification, and Characterization of a Highly Active Xylose Reductase from Neurospora crassa (2005) (87)
- Comparison of the properties of prostaglandin H synthase-1 and -2. (2003) (85)
- The importance of the leader sequence for directing lanthionine formation in lacticin 481. (2008) (83)
- Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. (2006) (82)
- Post-translational modifications during lantibiotic biosynthesis. (2004) (82)
- Convergent synthesis of peptide conjugates using dehydroalanines for chemoselective ligations. (2001) (81)
- Development and Application of Yeast and Phage Display of Diverse Lanthipeptides (2018) (80)
- The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry (2013) (79)
- Identification of Essential Catalytic Residues of the Cyclase NisC Involved in the Biosynthesis of Nisin* (2007) (78)
- Biosynthesis of the Class III Lantipeptide Catenulipeptin (2012) (78)
- Novel cofactors via post-translational modifications of enzyme active sites. (2000) (77)
- Inhibition of Bacillus anthracis Spore Outgrowth by Nisin (2008) (76)
- Insights into the functional role of the tyrosine-histidine linkage in cytochrome c oxidase [17] (2000) (75)
- Structure-activity relationship studies of the two-component lantibiotic haloduracin. (2008) (74)
- Use of a scaffold peptide in the biosynthesis of amino acid–derived natural products (2019) (73)
- The many roles of glutamate in metabolism (2016) (73)
- In vitro reconstitution and substrate specificity of a lantibiotic protease. (2008) (71)
- An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate (2012) (71)
- SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. (2003) (71)
- Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products (2017) (70)
- Biomimetic studies on the mechanism of stereoselective lanthionine formation. (2003) (70)
- Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. (2011) (68)
- Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate. (1998) (67)
- Substrate Control in Stereoselective Lanthionine Biosynthesis (2014) (64)
- Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin. (2016) (64)
- Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes (2016) (63)
- Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. (2005) (63)
- Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. (2007) (62)
- Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. (2011) (62)
- Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. (2010) (62)
- Biomimetic stereoselective formation of methyllanthionine. (2002) (61)
- Mechanistic investigation of a novel vitamin B(12)-catalyzed carbon [bond] carbon bond forming reaction, the reductive dimerization of arylalkenes. (2002) (61)
- Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic (2016) (61)
- Mechanism and applications of phosphite dehydrogenase. (2005) (59)
- Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. (2007) (58)
- A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2 (2014) (58)
- Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family (2020) (58)
- Expanded Natural Product Diversity Revealed by Analysis of Lanthipeptide-Like Gene Clusters in Actinobacteria (2015) (58)
- Properties and reactivity of chlorovinylcobalamin and vinylcobalamin and their implications for vitamin B12-catalyzed reductive dechlorination of chlorinated alkenes. (2005) (56)
- New developments in lantibiotic biosynthesis and mode of action. (2005) (56)
- Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis. (2017) (56)
- Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors. (1996) (55)
- Evolutionary radiation of lanthipeptides in marine cyanobacteria (2017) (55)
- The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation. (2014) (54)
- Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X (2012) (54)
- Mechanistic Studies of Ser/Thr Dehydration Catalyzed by a Member of the LanL Lanthionine Synthetase Family (2011) (54)
- Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS (2014) (53)
- Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry (2011) (53)
- Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides. (2004) (52)
- Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis. (2016) (51)
- Mechanistic Studies on the Substrate-Tolerant Lanthipeptide Synthetase ProcM (2014) (51)
- Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis (2017) (51)
- Ribosomal Natural Products, Tailored To Fit. (2017) (51)
- Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry (2009) (50)
- Tyrosyl radical cofactors. (2001) (49)
- The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. (2004) (49)
- Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry (2013) (49)
- Mechanistic Studies on the Vitamin B12-Catalyzed Dechlorination of Chlorinated Alkenes (2000) (48)
- Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. (2013) (48)
- High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis (2014) (47)
- The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold (2015) (47)
- Phosphite dehydrogenase: an unusual phosphoryl transfer reaction. (2001) (46)
- Different Biosynthetic Pathways to Fosfomycin in Pseudomonas syringae and Streptomyces Species (2012) (46)
- Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids (2009) (45)
- Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. (2008) (44)
- Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. (2009) (43)
- Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin (2018) (42)
- Selenocysteine Derivatives for Chemoselective Ligations (2002) (42)
- Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates. (2003) (42)
- Genetic and Biochemical Characterization of a Pathway for the Degradation of 2-Aminoethylphosphonate in Sinorhizobium meliloti 1021* (2011) (42)
- Substrate Selectivity of the Sublancin S-Glycosyltransferase (2011) (41)
- Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways* (2008) (41)
- Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. (2009) (41)
- Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. (2002) (41)
- Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt (2014) (40)
- Insights into the evolution of lanthipeptide biosynthesis (2013) (40)
- NMR Structure of the S-Linked Glycopeptide Sublancin 168 (2014) (40)
- Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli. (2012) (39)
- Optimizing a biocatalyst for improved NAD(P)H regeneration: directed evolution of phosphite dehydrogenase. (2006) (39)
- Chemical and Enzymatic Synthesis of Lanthionines (2005) (39)
- Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis. (2017) (38)
- Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. (2011) (38)
- Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. (2010) (38)
- Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants. (2002) (38)
- Structural basis for methylphosphonate biosynthesis (2017) (37)
- Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies (2006) (37)
- Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. (2005) (36)
- Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. (2014) (36)
- Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease (2019) (35)
- The Phosphoenolpyruvate:Sugar Phosphotransferase System Is Involved in Sensitivity to the Glucosylated Bacteriocin Sublancin (2015) (35)
- Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control. (2015) (35)
- Post-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ (2015) (35)
- New insights into the biosynthesis of fosfazinomycin (2016) (35)
- The leader peptide is not required for post-translational modification by lacticin 481 synthetase (2007) (35)
- Hydroperoxylation by Hydroxyethylphosphonate Dioxygenase (2009) (34)
- Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid. (2015) (33)
- Structure and mechanism of lanthipeptide biosynthetic enzymes. (2014) (33)
- O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides. (2019) (33)
- Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis (2010) (33)
- Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. (2008) (33)
- Michael-type cyclizations in lantibiotic biosynthesis are reversible. (2015) (33)
- Inhibition and pH dependence of phosphite dehydrogenase. (2005) (32)
- Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. (2003) (32)
- Lacticin 481 Synthetase as a General Serine/Threonine Kinase (2009) (32)
- Reductive Dechlorination of Trichloroethylene: A Computational Study (2002) (31)
- Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation (2012) (31)
- On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase (2011) (31)
- A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. (2013) (31)
- Heterologous expression and purification of SpaB involved in subtilin biosynthesis. (2002) (31)
- On the substrate specificity of dehydration by lacticin 481 synthetase. (2007) (30)
- Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium. (2016) (30)
- Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems. (2018) (30)
- Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway (2013) (30)
- Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. (2007) (30)
- Catalytic promiscuity of a bacterial α‐N‐methyltransferase (2012) (30)
- The dehydratase activity of lacticin 481 synthetase is highly processive. (2006) (29)
- Structure-activity relationships of the phosphonate antibiotic dehydrophos. (2010) (29)
- Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3. (2018) (29)
- Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration. (2012) (29)
- O–H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase (2017) (28)
- Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics (2019) (28)
- A quantum chemical study of the synthesis of prostaglandin G2 by the cyclooxygenase active site in prostaglandin endoperoxide H synthase 1 (2003) (28)
- Site-directed mutagenesis of active site residues of phosphite dehydrogenase. (2005) (28)
- Theoretical investigations into the intermediacy of chlorinated vinylcobalamins in the reductive dehalogenation of chlorinated ethylenes. (2005) (28)
- Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. (1998) (28)
- Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO (2014) (28)
- Insights into the Biosynthesis of Duramycin (2016) (28)
- Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species (2015) (27)
- The Antibiotic Dehydrophos Is Converted to a Toxic Pyruvate Analog by Peptide Bond Cleavage in Salmonella enterica (2011) (27)
- Mode of action and structure–activity relationship studies of geobacillin I (2013) (27)
- Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes (2017) (27)
- Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. (2016) (27)
- Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase (2017) (27)
- Structure-Activity Relationships of the S-Linked Glycocin Sublancin. (2017) (26)
- On the regioselectivity of thioether formation by lacticin 481 synthetase. (2007) (26)
- Converging on a mechanism for choline degradation (2012) (25)
- Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. (2013) (25)
- Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications. (2019) (25)
- Investigations into the Mechanism of Action of Sublancin. (2018) (25)
- Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration (2005) (25)
- Chapter 21. In vitro studies of lantibiotic biosynthesis. (2009) (24)
- Photochemical cleavage of leader peptides. (2010) (24)
- Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects. (2011) (24)
- Mechanistic Investigation of Methylphosphonate Synthase, a Non-Heme Iron-Dependent Oxygenase (2012) (24)
- Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics. (2018) (23)
- Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli. (2018) (23)
- Answers to the Carbon–Phosphorus Lyase Conundrum (2012) (23)
- A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase (2014) (23)
- Rings, Radicals, and Regeneration: the Early Years of a Bioorganic Laboratory (2006) (22)
- Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2. (2001) (22)
- An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase. (2003) (22)
- Structural Characterization of Arachidonyl Radicals Formed by Aspirin-treated Prostaglandin H Synthase-2* (2002) (22)
- On the role of alkylcobalamins in the vitamin B12-catalyzed reductive dehalogenation of perchloroethylene and trichloroethylene. (2006) (22)
- Bacillus anthracis spore interactions with mammalian cells: Relationship between germination state and the outcome of in vitro (2011) (21)
- Synthesis of nonproteinogenic amino acids to probe lantibiotic biosynthesis. (2005) (20)
- Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus. (2020) (20)
- Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. (2011) (20)
- Synergistic binding of the leader and core peptides by the lantibiotic synthetase HalM2. (2015) (20)
- Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli. (2018) (20)
- Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin. (2018) (19)
- The leader peptide is not required for post-translational modification by lacticin 481 synthetase. (2007) (19)
- A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase. (2015) (19)
- Biosynthesis of fosfazinomycin is a convergent process (2014) (19)
- Mechanism and Substrate Recognition of 2-Hydroxyethylphosphonate Dioxygenase (2011) (18)
- Characterization of chlorovinylcobalamin, a putative intermediate in reductive degradation of chlorinated ethylenes. (2003) (18)
- Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin (2018) (18)
- Engineering of new-to-nature ribosomally synthesized and post-translationally modified peptide natural products. (2021) (18)
- Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. (2014) (18)
- Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage† †Electronic supplementary information (ESI) available: Molecular biology procedures, protein expression and purifications, procedures for enzyme assays, supplementary figures and tables. (2015) (17)
- LanCL proteins are not Involved in Lanthionine Synthesis in Mammals (2017) (17)
- Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. (2004) (17)
- Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB. (2018) (16)
- Discovery and Characterization of a Class IV Lanthipeptide with a Non-overlapping Ring Pattern. (2020) (16)
- Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1. (1996) (16)
- Pre-steady-state studies of phosphite dehydrogenase demonstrate that hydride transfer is fully rate limiting. (2007) (16)
- LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome (2021) (15)
- Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2. (2020) (15)
- In Vitro Characterization of a Heterologously Expressed Nonribosomal Peptide Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis† (2009) (15)
- esized and post-translationally modi fi ed peptide natural products : overview and recommendations for a universal nomenclature (2012) (15)
- Dichloroacetylene is not the precursor to dichlorinated vinylcobaloxime and vinylcobalamin in cobalt catalyzed dechlorination of perchloro- and trichloroethylene. (2002) (15)
- Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) (2013) (15)
- Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin. (2016) (15)
- Homemade cofactors: Self-processing in galactose oxidase (2001) (14)
- Efficient Synthesis of Suitably Protected β-Difluoroalanine and γ-Difluorothreonine from l-Ascorbic Acid (2007) (14)
- Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase. (2008) (14)
- Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. (2008) (14)
- Rings, radicals, and regeneration: the early years of a bioorganic laboratory. (2006) (14)
- The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis. (2016) (14)
- Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads. (2017) (13)
- Investigation of the Role of Arg301 Identified in the X-ray Structure of Phosphite Dehydrogenase (2012) (13)
- Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern. (2021) (13)
- Synthesis of 2-amino-3-fluoroacrylic acid containing peptides. (2001) (13)
- Conjugation to Albumin‐Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin (2014) (13)
- Discovery and biosynthesis of phosphonate and phosphinate natural products. (2012) (13)
- Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine. (2014) (13)
- Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function. (2006) (13)
- Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides. (2022) (12)
- Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase (2014) (12)
- The Enzymology of Prochlorosin Biosynthesis. (2018) (12)
- The Fellowship of the Rings: Macrocyclic Antibiotic Peptides Reveal an Anti-Gram-Negative Target. (2020) (11)
- Non-ribosomal Peptide Extension by a Peptide Amino-acyl tRNA Ligase. (2019) (10)
- Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM (2016) (10)
- Expressed protein ligation for metalloprotein design and engineering. (2009) (10)
- Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post‐translationally Modified Peptides in Lachnospiraceae (2020) (10)
- A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor (2021) (10)
- Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways† (2020) (10)
- MicroED in natural product and small molecule research. (2020) (9)
- Cameo appearances of aminoacyl-tRNA in natural product biosynthesis. (2016) (9)
- CylA is a sequence-specific protease involved in toxin biosynthesis (2019) (9)
- Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM. (2021) (9)
- Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. (2008) (9)
- Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases. (2019) (9)
- Model studies of the Cu(B) site of cytochrome c oxidase utilizing a Zn(II) complex containing an imidazole-phenol cross-linked ligand. (2006) (9)
- Probing the role of the backbone carbonyl interaction with the CuA center in azurin by replacing the peptide bond with an ester linkage. (2016) (8)
- Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping. (2011) (8)
- Chemical and Enzymatic Synthesis of Fluorinated‐Dehydroalanine‐Containing Peptides (2003) (8)
- Vitamin B12 catalyzed radical cyclizations of arylalkenes (2006) (8)
- 5.08 – Biosynthesis and Mode of Action of Lantibiotics (2010) (8)
- Mechanisms and Evolution of Diversity-Generating RiPP Biosynthesis (2021) (8)
- Mechanistic Investigation of a Novel Vitamin B12-Catalyzed Carbon—Carbon Bond Forming Reaction, the Reductive Dimerization of Arylalkenes. (2002) (7)
- Investigation of Amide Bond Formation during Dehydrophos Biosynthesis. (2018) (7)
- Bacteria Do It Differently: An Alternative Path to Squalene (2015) (7)
- Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ. (2011) (7)
- Temperature independent kinetic isotope effects as evidence for a Marcus-like model of hydride tunneling in phosphite dehydrogenase. (2019) (7)
- Synthesis of Antibiotics and Related Molecules. (2018) (7)
- Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin. (2019) (6)
- Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT (2022) (6)
- Biosynthesis of 3-thia-α-amino acids on a carrier peptide (2022) (6)
- Substrate Recognition by the Peptidyl-(S)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis (2022) (6)
- Exploring structural signatures of the lanthipeptide prochlorosin 2.8 using tandem mass spectrometry and trapped ion mobility-mass spectrometry (2021) (6)
- 18O Kinetic Isotope Effects Reveal an Associative Transition State for Phosphite Dehydrogenase Catalyzed Phosphoryl Transfer. (2018) (6)
- Editorial overview: Biocatalysis and Biotransformation: Esoteric, Niche Enzymology. (2016) (6)
- Lighting up the nascent cell wall. (2006) (5)
- Macrocyclization and Backbone Modification in RiPP Biosynthesis. (2022) (5)
- Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. (2022) (5)
- An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase† †Electronic supplementary information (ESI) available: General experimental procedures, primer sequences, and supporting figures. See DOI: 10.1039/c2cc34138g Click here for additional data file. (2012) (5)
- Structure-Activity Relationships of the Enterococcal Cytolysin. (2021) (5)
- Corrigendum to: ‘Novel cofactors via post-translational modifications of enzyme active sites’ (2001) (5)
- Using expressed protein ligation to probe the substrate specificity of lantibiotic synthetases. (2009) (5)
- Oligosaccharide—Peptide Ligation of Glycosyl Thiolates with Dehydropeptides: Synthesis of S-Linked Mucin-Related Glycopeptide Conjugates. (2004) (5)
- The Antimicrobial Activity of the Glycocin Sublancin Is Dependent on an Active Phosphoenolpyruvate-Sugar Phosphotransferase System. (2021) (5)
- Introduction: Unusual Enzymology in Natural Product Synthesis (2017) (4)
- Overall Retention of Methyl Stereochemistry during B12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis (2021) (4)
- Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily (2021) (4)
- Site‐Selective Conjugation of Thiols with Aziridine‐2‐carboxylic Acid‐Containing Peptides. (2005) (4)
- Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product. (2022) (4)
- Introduction: Unusual Enzymology in Natural Product Synthesis. (2017) (4)
- Vitamin B12 Catalyzed Radical Cyclizations of Arylalkenes. (2006) (4)
- A scalable platform to discover antimicrobials of ribosomal origin (2022) (4)
- An unexpected role for ergothioneine (2015) (3)
- An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase w (2012) (3)
- Mechanistic Studies on Dehydration in Class V Lanthipeptides (2022) (3)
- Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis. (2012) (3)
- Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation[S] (2018) (3)
- RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides (2014) (3)
- Lighting Up the Nascent Cell Wall (2006) (3)
- Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2. (2007) (3)
- Divergent Evolution of Lanthipeptide Stereochemistry (2022) (2)
- Lantibiotics: Biosynthesis and Modes of Action (2008) (2)
- Structural and mechanistic investigations of protein S-glycosyltransferases. (2021) (2)
- Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway (2022) (2)
- Recent Progress in Lanthipeptide Biosynthesis, Discovery, and Engineering (2020) (1)
- Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2. (2011) (1)
- Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel. (2006) (1)
- Conjugation of Selenols with Aziridine-2-Carboxylic Acid-Containing Peptides (2005) (1)
- The protein modification repertoire (2005) (1)
- Substrate Specificity of the Flavoenzyme BhaC1 That Converts a C-Terminal Trp to a Hydroxyquinone (2022) (1)
- the biosynthesis of fosfazinomycin † (2016) (1)
- Peptide backbone modifications in lanthipeptides. (2021) (1)
- Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1995) (1)
- Bacteria Do It Differently: An Alternative Path to Squalene. (2015) (1)
- Synthesis of Fluorescent Lanthipeptide Cytolysin S Analogues by Late-Stage Sulfamidate Ring Opening (2023) (0)
- Mechanistic investigation of HalM2, one of two bifunctional enzymes involved in haloduracin biosynthesis (2007) (0)
- Solution NMR of Prochlorosin 2.8 produced by Prochlorococcus MIT 9313 (2020) (0)
- Cover Picture: Conjugation to Albumin‐Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin (ChemMedChem 10/2014) (2014) (0)
- A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria (2023) (0)
- Never stop questioning (2007) (0)
- Introducing unnatural amino acids into protein metal-binding sites and its role in metalloprotein design and engineering (2003) (0)
- Author response: Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease (2018) (0)
- An unexpected role for ergothioneine Zedu Huang and (2015) (0)
- The cellular and mechanistic study of nisin inhibition of bacillus anthracis spore outgrowth, nisin alteration of infection, and native producer immunity (2011) (0)
- Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid. (2007) (0)
- Solution NMR structure of enterococcal cytolysin S (CylLS"") produced by Enterococcus faecalis (2020) (0)
- Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family (2020) (0)
- [Movement therapy in the psychiatric hospital]. (1970) (0)
- Solution NMR structure of enterococcal cytolysin L (CylLL"") produced by Enterococcus faecalis (2020) (0)
- Solution structure of OlvA(BCS) (2019) (0)
- Improved production of class I lanthipeptides in Escherichia coli (2023) (0)
- Correction: Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways (2020) (0)
- Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease (2019) (0)
- Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin (2018) (0)
- Catalytic Use of a Leader Peptide in the Biosynthesis of 3-Thiaglutamate (2018) (0)
- Cover Picture: Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids (ChemBioChem 5/2009) (2009) (0)
- Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692 (2023) (0)
- Structural description of enzyme catalysing unusual modification in lantibiotic biosynthesis (2010) (0)
- The protein modification repertoire (2005) (0)
- Nature's way to make the lantibiotics (2006) (0)
- Substrate Recognition in Lantibiotic Biosynthesis (2015) (0)
- Solution NMR structure of Prochlorosin 2.10 produced by Prochlorococcus MIT 9313 (2020) (0)
- Investigations into the role of Lantibiotic Cyclase‐like (LanCL) proteins in mammals (2013) (0)
- A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product (2023) (0)
- Mechanistic aspects of chlorinated ethylene degradation by vitamin B12 (2005) (0)
- The identification and characterization of novel antibacterial compounds via target-based and whole cell screening approaches (2011) (0)
- The mechanism of thia-Michael addition catalyzed by LanC enzymes (2023) (0)
- [Illinois] RiPPs: A Treasure Trove for Bioengineering (2014) (0)
- PEARL mediated biosynthesis: a novel pathway to aromatic amines (2022) (0)
- he class II lanthipeptide protease LicP for sequence-speci fi c , traceless peptide bond cleavage † (2015) (0)
- Development of Phage Display of Nisin (2018) (0)
- Biochemistry: Positive and radical (2013) (0)
- Author response: The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold (2015) (0)
- Solution structure of OlvA(BC) (2019) (0)
- Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes (2016) (0)
- Sequence Controlled Secondary Structure Determines Site-selectivity of Lanthipeptides (2022) (0)
- syn-Elimination of glutamylated threonine in lanthipeptide biosynthesis (2022) (0)
- The frontiers of medicine (2009) (0)
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