William Beltran
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French–American ophthalmologist
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William Beltranmedical Degrees
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William Beltran's Degrees
- Doctorate Veterinary Medicine University of Pennsylvania
- PhD Genetics University of Pennsylvania
Why Is William Beltran Influential?
(Suggest an Edit or Addition)According to Wikipedia, William Anthony Beltran is a French–American ophthalmologist. He is a professor of ophthalmology in the Department of Clinical Sciences and Advanced Medicine and director of the Division of Experimental Retinal Therapies at the University of Pennsylvania School of Veterinary Medicine. In 2020, Beltran was elected a Member of the National Academy of Medicine for his research focus on inherited retinal degeneration.
William Beltran's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement (2013) (402)
- Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa (2012) (240)
- Human cone photoreceptor dependence on RPE65 isomerase (2007) (142)
- A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa. (2006) (114)
- Canine Retina Has a Primate Fovea-Like Bouquet of Cone Photoreceptors Which Is Affected by Inherited Macular Degenerations (2014) (101)
- Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector (2018) (98)
- Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells (2014) (95)
- rAAV2/5 gene-targeting to rods: dose-dependent efficiency and complications associated with different promoters (2010) (73)
- Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease (2015) (72)
- Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. (2013) (67)
- Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations. (2017) (58)
- BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure (2018) (57)
- Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. (2005) (55)
- Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects (2013) (50)
- Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor α (CNTFRα) (2003) (48)
- Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy. (2020) (41)
- The use of canine models of inherited retinal degeneration to test novel therapeutic approaches. (2009) (40)
- Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation. (2016) (37)
- Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration (2014) (35)
- Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. (2007) (35)
- Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations. (2009) (34)
- Photoreceptor Cell Death, Proliferation and Formation of Hybrid Rod/S-Cone Photoreceptors in the Degenerating STK38L Mutant Retina (2011) (34)
- Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus). (2007) (32)
- Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. (2015) (29)
- Up-Regulation of Tumor Necrosis Factor Superfamily Genes in Early Phases of Photoreceptor Degeneration (2013) (29)
- Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). (2003) (28)
- Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration (2017) (27)
- Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog. (2012) (26)
- Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina? (2007) (26)
- scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution (2021) (18)
- CREB1/ATF1 activation in photoreceptor degeneration and protection. (2009) (17)
- Exclusion of the Unfolded Protein Response in Light-Induced Retinal Degeneration in the Canine T4R RHO Model of Autosomal Dominant Retinitis Pigmentosa (2015) (16)
- Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition. (2009) (15)
- Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration. (2010) (14)
- Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa (2017) (12)
- Toxicity and Efficacy Evaluation of an AAV Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa. (2020) (12)
- Translational Retinal Research and Therapies (2018) (11)
- Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy. (2020) (10)
- Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma. (2013) (9)
- Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations (2020) (8)
- Ndr kinases regulate retinal interneuron proliferation and homeostasis (2018) (8)
- On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde? (2008) (8)
- Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry. (2019) (8)
- Progress in Gene Therapy for Rhodopsin Autosomal Dominant Retinitis Pigmentosa. (2019) (8)
- Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. (2003) (7)
- Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. (2014) (6)
- Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness (2021) (6)
- Focal/multifocal and geographic retinal dysplasia in the dog-In vivo retinal microanatomy analyses. (2019) (6)
- scAAVengr: Single-cell transcriptome-based quantification of engineered AAVs in non-human primate retina (2020) (5)
- Automatic segmentation of canine retinal OCT using adaptive gradient enhancement and region growing (2016) (5)
- Sustained Therapeutic Reversal of Canine Bestrophinopathy with Gene Therapy using Recombinant AAV2 (2013) (5)
- Gene Therapy Reforms Photoreceptor Structure and Restores Vision in NPHP5-associated Leber Congenital Amaurosis (2020) (5)
- Immunolocalization of Ciliary Neurotrophic Factor Receptor α (CNTFRα) in Mammalian Photoreceptor Cells (2015) (4)
- Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs (2022) (4)
- Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy (2021) (3)
- In-vivo longitudinal changes in thickness of the canine postnatal retina. (2020) (3)
- RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function. (2014) (3)
- Morphologic Analysis of Retinal Disease in the Area Centralis of RPGR-ORF15 Mutant Dogs (2007) (3)
- Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. (2018) (3)
- Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration (2013) (3)
- Development and validation of a canine-specific profiling array to examine expression of pro-apoptotic and pro-survival genes in retinal degenerative diseases. (2012) (2)
- Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases (2022) (2)
- Assessment of AAV-mediated RHO Augmentation in the Canine T4R RHO Model of Autosomal Dominant Retinitis Pigmentosa (2014) (2)
- Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration (2021) (2)
- Gene therapy for bestrophinopathies (2014) (2)
- Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography (2021) (2)
- Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa (2020) (2)
- Evaluation of AAV2tYF-GRK1-RPGR vectors in a canine model of RPGR-XLRP (2017) (1)
- Gene therapy for RPGR-XLRP in a canine model results in retained photoreceptors and vision for at least 2.5 years (2015) (1)
- Corrective Gene Therapy for RPGR-XLRP Rescues a Canine Model at Mid-Stage Disease (2013) (1)
- Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration (2014) (1)
- Azobenzene-based DENAQ photoswitch confers light sensitivity to degenerated but not to healthy canine retina (2016) (1)
- Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis (2018) (1)
- Directed evolution identifies novel AAV capsid variants for targeting the canine outer retina following intravitreal delivery (2016) (1)
- CNTFRα) in mammalian photoreceptor cells (2005) (1)
- Retinal structural and microvascular abnormalities in retinal dysplasia imaged by OCT and OCT angiography. (2021) (1)
- AAV-mediated gene augmentation restores retinal function and vision in the canine model of NPHP5 Leber congenital amaurosis (2016) (1)
- Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy (2019) (1)
- Cellular and molecular studies of ciliary neurotrophic factor receptor alpha expression and ciliary neurotrophic factor mediated neuroprotection in the canine retina (2006) (1)
- Systemic but Not Intravitreal Steroids Inhibit AP-1 in Light Exposed T4R Rhodopsin Mutant Dog Retina, but Neither Prevent Photoreceptor Degeneration (2008) (1)
- rAAV-mediated Gene Delivery of Truncated Canine RPGR Causes Photoreceptor Dysplasia in Dogs with RPGR-ORF15 Stop Mutation (2011) (1)
- Disease-based promoter selection for retinal gene therapy (2014) (1)
- Identification of circular RNAs hosted by the RPGR ORF15 genomic locus (2023) (0)
- Development of an optimized light damage paradigm to assess efficacy of gene therapy in a canine model of RHO-ADRP (2017) (0)
- Up-Regulation of Expression of Genes Belonging to the Tumor Necrosis Factor (TNF) Superfamily in RPGR-ORF15 Frameshift Mutant Retina (2010) (0)
- Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina (2022) (0)
- AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO-ADRP (2017) (0)
- Study of pro-apoptotic and pro-survival pathways at late stage disease in two non-allelic forms of photoreceptor degeneration (2016) (0)
- Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration (2018) (0)
- Author response: scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution (2021) (0)
- Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration (2021) (0)
- Prolactin Expression is Induced in Photoreceptors of Degenerating Retina (2019) (0)
- Intravitreal CNTF Injection Leads to Reversible Photoreceptor Deconstruction in the Normal Canine Retina (2011) (0)
- Photoreceptor Cell Death and Proliferation in the STK38L Mutant Dog Retina Precedes Development of Hybrid Rod/S-Cone Photoreceptors (2010) (0)
- New Developments in Vision Research Translational Retinal Research and Therapies (2018) (0)
- Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis. (2021) (0)
- Restoring visual function in blind mice and dogs with an improved 2nd generation azobenzene based photoswitch (2014) (0)
- Ndr kinases regulate retinal interneuron proliferation and homeostasis (2018) (0)
- Distinct phenotypic consequences of pathogenic C1QTNF5 mutants associated with late-onset retinal degeneration. (2022) (0)
- Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration (2018) (0)
- AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP (2018) (0)
- ASSESSMENT OF RETINAL STRUCTURE FOLLOWING REPEATED LIGHT EXPOSURE IN THE LIGHT SENSITIVE T4R RHODOPSIN MUTANT DOG RETINA (2013) (0)
- Immunolocalization of RPGR and RPGRIP in Normal Dogs, and in Mutants (XLPRA1/XLPRA2) Affected with Microdeletions of RPGR Exon ORF15 (2003) (0)
- Evaluation of CNTF’s Photoreceptor Rescue Effect in Affected XLPRA2 Dogs (2005) (0)
- 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery (2016) (0)
- Comparative Study of CLUL1, a Cone Photoreceptor Cell-specific Protein (2003) (0)
- GENETIC ABLATION OF 11-CIS RETINAL ACCELERATES RETINAL DEGENERATION IN THE CANINE T4R RHO MODEL OF ADRP BUT PREVENTS LIGHT-INDUCED DAMAGE (2015) (0)
- Successful Photoreceptor-Directed Gene Therapy with AAV2/5-hRPGR Reverses Post-Receptoral Remodeling in Canine Models of X-linked RP (2012) (0)
- AP–1 DNA Binding Activity in Retinas with RPGR Frame Shift Mutation (2006) (0)
- Bimodal Cell Death Kinetics in the STK 38L (erd) Mutant Dog Retina (2009) (0)
- Distinct Phenotypic Consequences of Pathogenic C1q e Tumor Necrosis Factor-5 Q3 Mutants Associated with Late-Onset Retinal Degeneration (2022) (0)
- Comparative Proteomic Analysis of Light Exposed and Unexposed T4R RHO Mutant Retinas (2009) (0)
- Immunocytochemical Localization of Ciliary Neurotrophic Factor Receptor (CNTFR) in the Retina of Mammalian Species (2003) (0)
- Photoreceptor function and structure in retinal degenerations caused by biallelic BEST1 mutations (2022) (0)
- Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes (2020) (0)
- Canine Multifocal Retinopathy (cmr1) Model of Human Best Macular Dystrophy: Imaging Earliest Retinal Lesions (2010) (0)
- Influence of Ambient Illumination on the Course of Retinal Degeneration in a Canine model of RHO-ADRP (2017) (0)
- Visual Behavior and Retinal Structure Following Acute Light Exposure in Normal and T4R RHO Dogs (2011) (0)
- Photoreceptor development, degeneration and retinal gene expression in the canine NPHP5 Leber congenital amaurosis model (2015) (0)
- Cloning and Expression of Ciliary Neurotrophic Factor Receptor (CNTFR) in the Canine Retina (2002) (0)
- Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis (2017) (0)
- NDR kinases regulate retinal development, homeostasis and gene expression (2017) (0)
- AAV2/5 Mediated Gene Augmentation Rescues Photoreceptors in Canine Models of RPGR-XLRP (2012) (0)
- Role of Endoplasmic Reticulum (ER) Stress Following Light Exposure in the Canine T4R RHO Mutant Model (2012) (0)
- Characterization of a Novel Prolactin Transcript in Photoreceptors of Degenerating Retina (2020) (0)
- Photoreceptor Cell Mitosis Preserves Outer Nuclear Layer During the Peak of Cell Death in the STK38L Mutant Dog Retina (2011) (0)
- BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments (2018) (0)
- Morphologic Analysis of Clonal Retinal Disease in Carriers of RPGRORF15 Frameshift Mutation (2006) (0)
- Expression of apoptosis inhibiting proteins, XIAP and Survivin, in the mammalian retina (2015) (0)
- Characterization of Photoreceptor Loss and Inner Retinal Remodeling in a Canine Model of Cone-Rod Dystrophy (CRD2) (2010) (0)
- Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration (2017) (0)
- Photoreceptor structure and gene expression in the canine NPHP5-LCA ciliopathy model (2016) (0)
- The use of canine models to develop translational gene therapies for the treatment of six forms of inherited retinal degenerations (2022) (0)
- Common Apoptosis-Related miRNA Expression During Chronic Photoreceptor Cell Death in Canine Models (2012) (0)
- Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations (2022) (0)
- Tandem Delivery of Short Hairpin RNAs and Rhodopsin cDNA to Combat Retinal Degeneration in Autosomal Dominant Retinitis Pigmentosa (2017) (0)
- Efficiency of rAAV5 Vectors Containing Three Different Promoters for Rod Transduction in the Canine Retina (2010) (0)
- Early disease phenotype in canine RPGRORF15 model is characterized by strong up-regulation of pro-inflammatory genes and down-regulation of neuroretinal maintenance genes (2015) (0)
- Association of long-term RPE65 expression and photoreceptor preservation in RPE65-gene therapy-treated canines (2018) (0)
- Two AAV2/5-mediated RPGR gene augmentation constructs driven by the GRK1 promoter rescue photoreceptor structure and function in a canine model of RPGR X-linked retinitis pigmentosa (2016) (0)
- Preface: Special 'retina' issue. (2012) (0)
- rAAV-Mediated Gene Delivery of a Rho Knockdown and Replacement Construct in the Canine Retina (2011) (0)
- Retinal Remodeling in a Canine Model of Early Onset Retinitis Pigmentosa (2008) (0)
- Canine Bestrophinopathies: Lesion Morphology and Molecular Pathology (2012) (0)
- Evaluation of the efficacy of mouse opsin promoter for rhodopsin gene augmentation in dogs (2015) (0)
- Retinal histopathology of X–linked Progressive Retinal Atrophy 2 (XLPRA2), a canine model of early onset X–linked Retinitis Pigmentosa. (2004) (0)
- Optimization of Rod Photoreceptor Culture and Rod Outer Segment Isolation from a Single Canine Retina (2014) (0)
- Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations (2022) (0)
- Disease Associated Changes in Gene Expression in RPGRORF15 Frameshift Mutant Retina (2009) (0)
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