William Bosworth Castle | Academic Influence

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William Bosworth Castle

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Philosophy

William Bosworth Castle's Degrees

Doctorate Medicine Harvard University

Why Is William Bosworth Castle Influential?

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According to Wikipedia, William Bosworth Castle was an American physician and physiologist who transformed hematology from a "descriptive art to a dynamic interdisciplinary science." Life Castle was born to William E. Castle and his wife in Cambridge, Massachusetts. His father was a professor of zoology at Harvard, a pioneer in mammalian genetics, and a member of the U.S. National Academy of Sciences. The young Castle was educated in local schools and entered Harvard College in 1914. At the end of his third year of college, he enrolled in Harvard Medical School. Upon graduating from medical school, he did a medical internship at the Massachusetts General Hospital from 1921-1923.

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William Bosworth Castle's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Studies on the destruction of red blood cells; irreversibly sickled erythrocytes; their experimental production in vitro. (1943) (275)
Clinical determination of the sites of red cell sequestration in hemolytic anemias. (1956) (268)
The destruction of red cells by antibodies in man. I. Observations of the sequestration and lysis of red cells altered by immune mechanisms. (1957) (237)
A simple and rapid method for demonstrating sickling of the red blood cells; the use of reducing agents. (1948) (175)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XII. Failure of thymus aminopolypeptidase to act as intrinsic factor. (1929) (169)
Studies on the destruction of red blood cells. X. The biophysics and biology of sickle-cell disease. (1956) (149)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA.: III. THE NATURE OF THE REACTION BETWEEN NORMAL HUMAN GASTRIC JUICE AND BEEF MUSCLE LEADING TO CLINICAL IMPROVEMENT AND INCREASED BLOOD FORMATION SIMILAR TO THE EFFECT OF LIVER FEEDING (1930) (139)
Red cell filtration and the pathogenesis of certain hemolytic anemias. (1961) (137)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA (1929) (112)
Sequential mechanisms in the enhanced absorption of vitamin B12 by intrinsic factor in the rat. (1960) (109)
IN VITRO ASSAY FOR HUMAN INTRINSIC FACTOR. (1963) (107)
QUANTITATIVE ASPECTS OF IRON DEFICIENCY IN HYPOCHROMIC ANEMIA: (The Parenteral Administration of Iron). (1932) (103)
EXPERIMENTAL AND CLINICAL OBSERVATIONS ON INCREASED MECHANICAL FRAGILITY OF ERYTHROCYTES. (1944) (103)
Erythropoietic effect of cobalt in patients with or without anemia. (1949) (91)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XIII. Hematopoietic activity of vitamin B12a (Vitamin B12b). (1948) (90)
The serum vitamin B12 concentration in pernicious anemia. (1954) (90)
Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy. (1968) (89)
Development of knowledge concerning the gastric intrinsic factor and its relation to pernicious anemia. (1953) (86)
Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection. (1971) (85)
STUDIES OF ANEMIA IN PREGNANCY: I. Gastric Secretion in Pregnancy and the Puerperium (1932) (71)
THE INTERPRETATION OF RETICULOCYTE REACTIONS THEIR VALUE IN DETERMINING THE POTENCY OF THERAPEUTIC MATERIALS, ESPECIALLY IN PERNICIOUS ANEMIA (1935) (66)
Studies on the destruction of red blood cells. XII. Factors influencing the role of S hemoglobin in the pathologic physiology of sickle cell anemia and related disorders. (1957) (61)
Absorption of polyglutamic folate: participation of deconjugating enzymes of the intestinal mucosa. (1969) (59)
Etiology and treatment of sprue. Observations on patients in Puerto Rico and subsequent experiments on animals. (1935) (57)
The Nature of the Extrinsic Factor of the Deficiency State in Pernicious Anemia and in Related Macrocytic Anemias (1932) (53)
Divalent cation and pH dependence of rat intrinsic factor action in everted sacs and mucosal homogenates of rat small intestine. (1961) (52)
Pathological Physiology and Clinical Description of the Anæmias (1937) (48)
Agglutination of sensitized red cells by large anisometric molecules. (1956) (47)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: IX. Difference in Site of Secretion of Intrinsic Factor in the Hog and in the Human Stomach (1942) (42)
SUSCEPTIBILITY OF ERYTHROCYTES TO HYPOTONIC HEMOLYSIS AS A FUNCTION OF DISCOIDAL FORM (1937) (42)
PANCREATIC AND HEPATIC ACTIVITY IN DIABETES MELLITUS: THE ALTERATIONS WITH SOME OBSERVATIONS ON THE ETIOLOGY OF THE DISEASE (1925) (38)
Experimental Combined System Disease (1930) (38)
Current concepts of pernicious anemia. (1970) (38)
Pyridoxine-responsive anemia. (1960) (38)
STUDIES OF ANEMIA IN PREGNANCY: II. THE RELATIONSHIP OF DIETARY DEFICIENCY AND GASTRIC SECRETION TO BLOOD FORMATION DURING PREGNANCY (1932) (34)
Cyanocobalamin therapy effect in folic acid deficiency. (1962) (32)
SUSCEPTIBILITY OF MAMMALIAN ERYTHROCYTES TO HEMOLYSIS WITH HYPOTONIC SOLUTIONS: A FUNCTION OF DIFFERENCES BETWEEN DISCOIDAL VOLUME AND VOLUME OF A SPHERE OF EQUAL SURFACE (1937) (32)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: I. The Effect of the Administration to Patients with Pernicious Anemia of the Contents of the Normal Human Stomach Recovered after the Ingestion of Beef Muscle (1974) (32)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA.: VI. THE SITE OF THE INTERACTION OF FOOD (EXTRINSIC) AND GASTRIC (INTRINSIC) FACTORS; FAILURE OF in Vitro INCUBATION TO PRODUCE A THERMOSTABLE HEMATOPOIETIC PRINCIPLE (1937) (31)
STUDIES ON THE DESTRUCTION OF RED BLOOD CELLS V. IRREVERSIBLY SICKLED ERYTHROCYTES: THEIR EXPERIMENTAL PRODUCTION IN VITRO (1949) (29)
Enhanced Absorption of Vitamin B12 in Gastrectomized Rat by Rat Intrinsic Factor.∗ (1956) (29)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: II. The Effect of the Administration to Patients with Pernicious Anemia of Beef Muscle after Incubation with Normal Human Gastric Juice (1974) (29)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: V. FURTHER EVIDENCE FOR THE ESSENTIAL PARTICIPATION OF EXTRINSIC FACTOR IN HEMATOPOIETIC RESPONSES TO MIXTURES OF BEEF MUSCLE AND GASTRIC JUICE AND TO HOG STOMACH MUCOSA (1936) (28)
Observations on the mechanism of hemolytic transfusion reactions occurring without demonstrable hemolysin. (1950) (28)
Necrosis of the Jaw in Workers employed in applying a Luminous Paint containing Radium. (28)
OBSERVATIONS ON THE ETIOLOGY AND TREATMENT OF ANEMIA ASSOCIATED WITH HOOKWORM INFECTION IN PUERTO RICO (1934) (26)
INTRAVENOUS USE OF EXTRACT OF LIVER: MAXIMAL RESPONSES OF RETICULOCYTES FROM A SINGLE INJECTION DERIVED FROM ONE HUNDRED GRAMS OF LIVER: PRELIMINARY COMMUNICATION (1931) (26)
Nutritional macrocytic anemia, especially in pregnancy; response to a substance in liver other than that effective in pernicious anemia. (1946) (26)
The extrinsic (deficiency) factor in pernicious and related anaemias. (1932) (26)
Oxygen Saturation of Sternal Marrow Blood with Special Reference to Pathogenesis of Polycythemia Vera.∗ (1948) (24)
INTRAMUSCULAR USE OF LIVER EXTRACT: MAXIMAL RESPONSES OF RETICULOCYTES FROM DAILY INTRAMUSCULAR INJECTION OF EXTRACT DERIVED FROM TEN GRAMS OF LIVER: PRELIMINARY COMMUNICATION (1931) (24)
The Coexistence of Myxedema and Pernicious Anemia (1931) (24)
EXTRINSIC FACTOR IN PERNICIOUS ANEMIA: INEFFECTIVENESS OF PURIFIED CASEIN AND OF IDENTIFIED COMPONENTS OF THE VITAMIN B COMPLEX. (1944) (23)
THE ETIOLOGY OF PERNICIOUS AND RELATED MACROCYTIC ANEMIAS. (1935) (22)
Mechanism of Intrinsic Factor Action in the Gastrectomized Rat.∗ (1957) (19)
PLASMA CELL LEUKEMIA. A CONSIDERATION OF THE LITERATURE WITH THE REPORT OF A CASE (1936) (19)
THE ÆTIOLOGY AND TREATMENT OF SPRUE IN PORTO RICO. (1932) (18)
Hematologic observations in bacterial endocarditis, especially the prevalence of histiocytes and the elevation and variation of the white cell count in blood from the ear lobe. (1956) (18)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XV. Hematopoietic effects of simultaneous intravenous and of simultaneous or serial oral administration of intrinsic factor and vitamin B12. (1953) (18)
Studies of anemia of pregnancy. 3. The etiological relationship of gastric secretory defects and dietary deficiency to the hypochromic and macrocytic (pernicious) anemias of pregnancy and the treatment of these conditions. (1933) (17)
Factors involved in the absorption of vitamin B12. (1959) (17)
The Pathology of the Bone Marrow in Sprue Anemia. (1933) (16)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA. VII. RESEMBLANCES BETWEEN THE PROTEOLYTIC ACTIVITY OF NORMAL HUMAN GASTRIC JUICE ON CASEIN IN NEUTRAL SOLUTION AND THE ACTIVITY OF THE INTRINSIC FACTOR. (1938) (16)
OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: XIV. Intrinsic Factor Activity of Desiccated and Defatted Human Fundus, Duodenum, and Jejunum (1952) (15)
White paper on the therapeutic equivalence of chemically equivalent drugs. (1969) (14)
The Adequate Treatment of Anemia (1931) (13)
On the Nomenclature of the Anti-Rh Typing Serums: Report of the Advisory Review Board. (1948) (13)
PARENTERAL LIVER THERAPY IN THE TREATMENT OF PERNICIOUS ANEMIA (1932) (13)
The Ætiological Relationship of Achylia Gastrica to Pernicious Anæmia (1929) (12)
HOOKWORM ANEMIA: ETIOLOGY AND TREATMENT WITH ESPECIAL REFERENCE TO IRON (1934) (12)
Destruction of Red Blood Cells. VII. Apparent Autosensitization to Dog Red Blood Cells.∗ (1949) (12)
Present status of the etiology of pernicious anemia. (1951) (12)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. 11. Hematopoietic activity in pernicious anemia of a beef muscle extract containing food (extrinsic) factor upon intravenous injection without contact with gastric (intrinsic) factor. (1949) (12)
THE ETIOLOGY OF PERNICIOUS ANEMIA AND RELATED MACROCYTIC ANEMIAS (1933) (12)
Supplemental folic acid therapy in pernicious anemia: the effect on erythropoiesis and serum vitamin B12 concentrations in selected cases. (1956) (12)
ASSAY OF COMMERCIAL EXTRACTS OF LIVER FOR PARENTERAL USE IN PERNICIOUS ANEMIA: METHOD OF SUCCESSIVE RETICULOCYTE RESPONSES IN THE SAME PATIENT (1934) (11)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. 13. Hematopoietic activity of vitamin B12 (vita-min B12b)-. (1951) (11)
STUDIES IN THE METABOLISM OF MUSCLE (1927) (11)
Observations on the etiologic relationship of achylia gastrica to pernicious anemia; activity of vitamin B12 as food, extrinsic factor. (1948) (10)
The Site of Vitamin B12-Intrinsic Factor Complex “Releasing Factor” Activity in the Rat Small Intestine (1962) (10)
Neuropathology of Experimental Vitamin Deficiency: A Report of Four Series of Dogs Maintained on Diets Deficient in the B Vitamins. (1935) (10)
Amount of Material Effective in Pernicious Anemia Present in Dog Liver (1933) (9)
Nutritional Macrocytic Anemia: Response to a Substance Other Than the Anti-Pernicious Anemia Principle.* (1945) (9)
Treatment of pernicious anemia: Historical aspects (1966) (9)
Correlation of in vitro Activity of Normal Human Gastric Juice on Casein at pH 7.4 with Gastric Intrinsic Factor (1937) (9)
PRESENT STATUS OF TREATMENT OF PERNICIOUS ANEMIA: NINTH ANNOUNCEMENT OF U. S. P. ANTI-ANEMIA PREPARATIONS ADVISORY BOARD (1959) (8)
The Gordon Wilson Lecture. A Century of Curiosity About Pernicious Anemia. (1962) (8)
Osmotic and Mechanical Fragilities of Erythrocytes of Monkeys Infected with P. knowlesi Malaria.∗ (1946) (8)
Releasing Factor and Endogenous Vitamin B12 ∗ (1965) (8)
EFFECT OF AUTOLYSIS ON POTENCY OF LIVER IN TREATMENT OF PERNICIOUS ANEMIA (1935) (7)
The contributions of George Richards Minot to experimental medicine. (1952) (7)
A DOMESTIC LIVER EXTRACT FOR USE IN PERNICIOUS ANEMIA: METHOD OF PREPARATION (1929) (6)
ORAL TREATMENT OF PERNICIOUS ANÆMIA (1958) (6)
Detection, recognition and management of anemia. (1959) (5)
Relation of Cholesterol and Lecithin to Remission in Pernicious Anemia. (1928) (5)
NUTRITIONAL MACROCYTIC ANEMIA, ESPECIALLY IN PREGNANCY: Response to a Substance in Liver Other than that Effective in Pernicious Anemia* (1946) (5)
FAILURE OF CHOLINE CHLORIDE TO AUGMENT ANEMIA IN CIRRHOSIS OF THELIVER (1945) (4)
Oral manifestations of blood dyscrasias (1941) (4)
Folic acid. A report of 12 patients treated with synthetic pteroylglutamic acid with comments on the pertinent literature. (1948) (4)
TESTS FOR URINARY BILIRUBIN (1945) (4)
THE ÆTIOLOGY AND TREATMENT OF ANEMIA IN PREGNANCY. (1932) (4)
III THE ETIOLOGIC RELATIONSHIP OF GASTRIC SECRETORY DEFECTS AND DIETARY DEFICIENCY TO THE HYPOCHROMIC AND MACROCYTIC (PERNICIOUS) ANEMIAS OF PREGNANCY AND THE TREATMENT OF THESE CONDITIONS (1933) (3)
Erythropoiesis: normal and abnormal. (1954) (3)
From man to molecule and back to mankind. (1976) (3)
COMPARISON OF THE EFFECTS OF MASSIVE BLOOD TRANSFUSIONS AND OF LIVER EXTRACT IN PERNICIOUS ANEMIA. (1946) (3)
YEAH BOOK OF MEDICINE, 1960???1961 SERIES (1961) (3)
Control of U.S.P. anti-anemia preparations; special report of the United States Pharmacopeia Anti-Anemia Preparations Advisory Board. (1953) (3)
MAXIMAL RETICULOCYTE RESPONSES FROM INTRAVENOUS INJECTION OF A LIVER EXTRACT. (1931) (3)
Laboratory diagnosis of polycythemia and anemia. (1950) (3)
THE RELATIONSHIP OF THE GASTROINTESTINAL TRACT TO ANEMIA (1937) (2)
Nutritional Megaloblastic Anemias: Etiological Considerations (1966) (2)
Some Remarks on Therapy for Anemia (1942) (2)
The AEtiological Relationship of Achylia Gastrica to Pernicious Anaemia. (2)
Physician as Scientist: Preparation, Performance, and Prospects. (1976) (2)
The Council on Pharmacy and Chemistry (1907) (2)
The Year Book of Medicine (1961???1962 Year Book Series) (1962) (2)
Negative Results of Treatment of Chronic Myelogenous Leukemia as a Deficiency Disease.∗ (1935) (2)
Present status of treatment of pernicious anemia. (1959) (2)
Achylia gastrica in retrospect. (1974) (1)
The etiology and treatment of anaemia in pregnancy. (1932) (1)
Vitamin B12 and folic acid in infant nutrition. (1951) (1)
George Hoyt Whipple and His Friends: The Life-Story of a Nobel Prize Pathologist. (1963) (1)
INFLUENCE OF ENVIRONMENTAL ALTERATIONS ON THE PERIPHERAL TRANSPORT AND METABOLISM OF THYROID HORMONE (1961) (1)
Journal of the American Medical Association, Volume 3, 1931. The relationship of disorders of the digestive tract to anemia. (1931) (1)
Erythropoietic activity of extrinsic factor on parenteral administration in pernicious anemia (1949) (1)
Grain-fed pigeons revisited: a pioneer test for vitamin B12. (1985) (1)
Alan Gregg Memorial Lecture. Physician as scientist: preparation, performance, and prospects. (1976) (1)
ETIOLOGIC CONSIDERATIONS IN MACROCYTIC ANEMIAS (1947) (0)
Year Book of Medicine (1954–1955 Series) (1955) (0)
Improved utilization of medical faculty. (1969) (0)
YEAR BOOK OF MEDICINE, 1959???1960 SERIES (1961) (0)
The Year Book of Medicine (1964–1965) Year Book Series) (1965) (0)
Thomas Hale Ham, M.D. (1976) (0)
George Cheever Shattuck (1973) (0)
MORTALITY FROM PERNICIOUS ANÆMIA IN ENGLAND AND WALES (1935) (0)
Vitamin-related anemias. Historical survey. (1968) (0)
Joseph Treloar Wearn (1985) (0)
Book Review: Ross's Post-mortem Appearances (1963) (0)
Disease Factors Conditioning Malnutrition (1945) (0)
[Studies on the intrinsic factor]. (1958) (0)
YEAR BOOK OF MEDICINE, 1957???1958 SERIES (1958) (0)
George Richards Minot. (1974) (0)
Clinical defects in the assimilation of vitamin B12. (1970) (0)
Memorial: George Cheever Shattuck, M.D. 1879-1972. (1973) (0)
Activation oftheHumanNeutrophil Nicotinamide AdenineDinucleotide Phosphate (NADPH)-Oxidase byProtein KinaseC (1985) (0)
Book Review: The Year Book of Medicine (1963) (0)
Laboratory diagnosis of polycythemia and anemia. (1950) (0)
THE YEAR BOOK OF MEDICINE (1966–1967 SERIES) (1967) (0)
Fifth Alex M. Burgess lecture: Alex M. Burgess and medicine: yesterday, today and tomarrow. (1970) (0)
Panels in Therapy: A New Department I. The Use of Intrinsic Factor-B12 Combinations in the Treatment of Pernicious Anemia (1955) (0)
Studies in the mechanism of hemolysis in congenital hemolytic jaundice; (hereditary spherocytosis). (1952) (0)
The Year Book of Medicine (1955???1956 Series) (1956) (0)
Editorial: From the breakfast table to the saddle-bag. (1974) (0)
The Relationship of Defective Nutrition to Changes in the Gastrointestinal Tract (1936) (0)
Megaloblastic anemia. (1978) (0)
Pernicious Anemia Then and Now. (1965) (0)

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What Schools Are Affiliated With William Bosworth Castle?

William Bosworth Castle is affiliated with the following schools:

Harvard University