William DeGrado
#55,019
Most Influential Person Now
American biochemist
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William DeGradobiology Degrees
Biology
#3140
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#4841
Historical Rank
#1311
USA Rank
Biochemistry
#310
World Rank
#377
Historical Rank
#130
USA Rank
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Biology
William DeGrado's Degrees
- PhD Chemistry University of California, Berkeley
Why Is William DeGrado Influential?
(Suggest an Edit or Addition)According to Wikipedia, William DeGrado is a professor at the University of California, San Francisco, where he is the Toby Herfindal Presidential Professor of Entrepreneurship and Innovation in the Department of Pharmaceutical Chemistry. As an early pioneer of protein design, he coined the term de novo protein design. He is also active in discovery of small molecule drugs for a variety of human diseases. He is a member of the U.S. National Academy of Sciences , American Academy of Arts & Sciences and National Academy of Inventors. He also is a scientific cofounder of Pliant therapeutics.
William DeGrado's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- beta-Peptides: from structure to function. (2001) (1331)
- A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. (1990) (1054)
- Foldamers as versatile frameworks for the design and evolution of function. (2007) (704)
- How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices (1990) (668)
- Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers (2010) (599)
- Synthetic amphiphilic peptide models for protein ion channels. (1988) (522)
- Characterization of a helical protein designed from first principles. (1988) (458)
- De novo design and structural characterization of proteins and metalloproteins. (1999) (448)
- De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. (2010) (447)
- Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. (2004) (441)
- Protein Design: A Hierarchic Approach (1995) (439)
- Protein design, a minimalist approach. (1989) (411)
- Amphiphilic polymethacrylate derivatives as antimicrobial agents. (2005) (400)
- Short peptides self-assemble to produce catalytic amyloids (2014) (394)
- De novo design of biomimetic antimicrobial polymers (2002) (385)
- Design and synthesis of multi-haem proteins (1994) (381)
- Structural basis for the function and inhibition of an influenza virus proton channel (2008) (366)
- Asparagine-mediated self-association of a model transmembrane helix (2000) (358)
- A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. (1997) (345)
- Polar side chains drive the association of model transmembrane peptides. (2001) (319)
- Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity (1985) (295)
- Helix-packing motifs in membrane proteins (2006) (282)
- De Novo Design of Antibacterial β-Peptides (1999) (279)
- Salt bridges: Geometrically specific, designable interactions (2011) (278)
- The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. (1999) (277)
- Structural basis for the function and inhibition of an influenza virus proton channel (2008) (276)
- De novo design of catalytic proteins. (2004) (275)
- De Novo Design, Synthesis, and Characterization of Antimicrobial β-Peptides (2001) (271)
- Computational Design of Peptides That Target Transmembrane Helices (2007) (267)
- De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers (2009) (262)
- Using nitrile-derivatized amino acids as infrared probes of local environment. (2003) (259)
- De novo design of helical bundles as models for understanding protein folding and function. (2000) (255)
- Design of a 4-helix bundle protein: synthesis of peptides which self-associate into a helical protein (1987) (254)
- The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives. (2009) (250)
- Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. (1987) (250)
- Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library (1992) (250)
- Crystal structure of a synthetic triple-stranded alpha-helical bundle. (1993) (241)
- De novo design of a transmembrane Zn2+-transporting four-helix bundle (2014) (239)
- Design of peptides and proteins. (1988) (234)
- Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity (2017) (228)
- Design of DNA-binding peptides based on the leucine zipper motif. (1990) (225)
- Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations (2003) (222)
- Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus (2010) (217)
- Metal ion-dependent modulation of the dynamics of a designed protein. (1993) (211)
- Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. (1982) (207)
- The αvβ1 integrin plays a critical in vivo role in tissue fibrosis (2015) (206)
- Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. (2000) (205)
- Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41. (1990) (202)
- Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces (2011) (194)
- Signal transduction in histidine kinases: insights from new structures. (2015) (193)
- Polymer-bound oxime esters as supports for solid-phase peptide synthesis. The preparation of protected peptide fragments (1980) (193)
- Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus (2013) (193)
- Nontoxic membrane-active antimicrobial arylamide oligomers. (2004) (190)
- Development of α-helical calpain probes by mimicking a natural protein-protein interaction. (2012) (185)
- Solution structure and dynamics of a de novo designed three-helix bundle protein. (1999) (185)
- Helix formation via conformation diffusion search (2002) (185)
- Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. (2000) (184)
- Design of a heme-binding four-helix bundle (1994) (181)
- Probing designability via a generalized model of helical bundle geometry. (2011) (180)
- The interaction of calmodulin with amphiphilic peptides. (1985) (180)
- p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide. (1986) (179)
- Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains (2001) (175)
- Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. (1999) (174)
- Protein-protein interactions in the membrane: sequence, structural, and biological motifs. (2008) (166)
- De novo designed synthetic mimics of antimicrobial peptides. (2008) (166)
- Synthetic peptides as models for ion channel proteins (1993) (163)
- How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices. (1990) (163)
- Seismostratigraphy and Thermal Structure of Earth ’ s Core-Mantle Boundary Region (2007) (161)
- Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice (2014) (160)
- Dimerization of the Transmembrane Domain of Integrin αIIb Subunit in Cell Membranes* (2004) (159)
- An artificial di-iron oxo-protein with phenol oxidase activity. (2009) (159)
- Design of three-dimensional domain-swapped dimers and fibrous oligomers. (2001) (159)
- Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. (1984) (159)
- Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability. (2001) (157)
- Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel (2009) (156)
- pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. (2000) (155)
- E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices. (2007) (152)
- Computational design of a protein crystal (2012) (150)
- Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles. (1991) (150)
- How do helix–helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo‐oligomeric helical bundles (2003) (149)
- DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A CYTOTOXIC PEPTIDE WITH MELITTIN-LIKE ACTIVITY (1981) (141)
- Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. (2005) (141)
- A push-pull mechanism for regulating integrin function. (2005) (140)
- Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. (2001) (140)
- β-Peptides: From Structure to Function (2001) (139)
- Ultrafast folding of α3D: A de novo designed three-helix bundle protein (2003) (138)
- Molecular characterization of helix-loop-helix peptides. (1992) (137)
- De novo protein design: from molten globules to native-like states (1993) (136)
- Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers (2003) (135)
- Computational design and characterization of a monomeric helical dinuclear metalloprotein. (2003) (134)
- Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. (2007) (132)
- Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. (2003) (130)
- Structural basis for proton conduction and inhibition by the influenza M2 protein (2012) (127)
- From coiled coils to small globular proteins: Design of a native‐like three‐helix bundle (1998) (126)
- Folding dynamics of single GCN-4 peptides by fluorescence resonant energy transfer confocal microscopy (1999) (125)
- Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. (2011) (125)
- Temperature-dependent helix-coil transition of an alanine based peptide. (2001) (122)
- Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16 (2014) (121)
- The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR (2003) (121)
- Computational de novo design, and characterization of an A(2)B(2) diiron protein. (2002) (119)
- Tetraphilin : a four-helix proton channel built on a tetraphenylporphyrin framework (1992) (118)
- Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles. (1992) (117)
- Cu(II) Inhibition of the Proton Translocation Machinery of the Influenza A Virus M2 Protein* (1999) (117)
- De Novo Design of Mercury-Binding Two- and Three-Helical Bundles (1997) (116)
- The crystal structure of the designed trimeric coiled coil coil‐VaLd: Implications for engineering crystals and supramolecular assemblies (1997) (116)
- De novo design of a Zn2+-binding protein (1990) (115)
- Solution Structure of α2D, a Nativelike de Novo Designed Protein (1998) (115)
- Pump/probe self heterodyned 2D spectroscopy of vibrational transitions of a small globular peptide (2000) (114)
- Template-Constrained Cyclic Peptides: Design of High-Affinity Ligands for GPIIb/IIIa (1994) (114)
- Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus (2009) (113)
- [37] Recognition and characterization of calmodulin-binding sequences in peptides and proteins (1987) (113)
- Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. (2011) (112)
- Design of a switchable eliminase (2011) (112)
- The twists and turns of beta-peptides. (1999) (112)
- The design, synthesis, and crystallization of an alpha‐helical peptide (1986) (112)
- De novo design of a redox-active minimal rubredoxin mimic. (2005) (111)
- Computational design of water-soluble analogues of the potassium channel KcsA (2004) (110)
- Crystal structure of alpha 1: implications for protein design. (1990) (109)
- Structural organization and interactions of transmembrane domains in tetraspanin proteins (2005) (109)
- Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ. (2014) (107)
- Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. (2011) (106)
- De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. (2010) (105)
- Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. (2013) (105)
- Solid-phase synthesis of protected peptides on a polymer-bound oxime: preparation of segments comprising the sequence of a cytotoxic 26-peptide analog (1982) (105)
- DNA-induced increase in the alpha-helical content of C/EBP and GCN4. (1991) (104)
- Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. (1996) (104)
- Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. (2010) (103)
- Residue-Specific Vibrational Echoes Yield 3D Structures of a Transmembrane Helix Dimer (2011) (102)
- In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. (1985) (102)
- Agonist-activated αvβ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin* (1997) (100)
- Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. (2009) (100)
- Structural Studies of a Family of High Affinity Ligands for GPIIb/IIIa (1994) (99)
- Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity. (1987) (98)
- The role of helix formation in the folding of a fully α‐helical coiled coil (1996) (96)
- Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. (1993) (96)
- The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. (1998) (94)
- Catalytic efficiency of designed catalytic proteins. (2014) (93)
- De novo design of a single-chain diphenylporphyrin metalloprotein. (2007) (93)
- Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease (2018) (92)
- Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins (2005) (92)
- Type II‘ to Type I β-Turn Swap Changes Specificity for Integrins (1996) (92)
- The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment (2005) (91)
- Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy (2011) (90)
- Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. (2013) (89)
- A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. (2004) (88)
- Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. (2009) (87)
- Peptide Conformational Dynamics and Vibrational Stark Effects Following Photoinitiated Disulfide Cleavage (1997) (87)
- Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. (2018) (86)
- Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. (2001) (85)
- High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction (2015) (85)
- Altering the O2-Dependent Reactivity of de novo Due Ferri Proteins (2012) (84)
- Artificial diiron proteins: From structure to function (2005) (83)
- Native-like and structurally characterized designed α-helical bundles (1995) (83)
- Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism (2009) (82)
- Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. (2006) (82)
- Proton and cation transport activity of the M2 proton channel from influenza A virus (2010) (82)
- Consensus motif for integrin transmembrane helix association (2009) (81)
- Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. (2001) (81)
- De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. (2017) (79)
- New design of helix bundle peptide-polymer conjugates. (2008) (78)
- Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain (2019) (77)
- An atomic environment potential for use in protein structure prediction. (2005) (77)
- The Activation State of αvβ3Regulates Platelet and Lymphocyte Adhesion to Intact and Thrombin-cleaved Osteopontin* (2000) (76)
- A de Novo Designed Protein Mimics the Native State of Natural Proteins (1995) (76)
- De novo protein design, a retrospective (2020) (74)
- Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment. (2011) (74)
- Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine. (1989) (74)
- De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. (1997) (74)
- Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer (2006) (73)
- Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel (2014) (73)
- Zinc-binding structure of a catalytic amyloid from solid-state NMR (2017) (72)
- Conformationally constrained α‐helical peptide models for protein ion channels (1990) (72)
- Antibacterial Mechanism of Action of Arylamide Foldamers (2011) (72)
- Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. (2003) (72)
- Solid-Phase Synthesis of Benzopiperazinones (1998) (71)
- Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion (2011) (71)
- In vitro evolution of thermodynamically stable turns (1996) (71)
- Packing of apolar side chains enables accurate design of highly stable membrane proteins (2019) (70)
- Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. (2012) (70)
- De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities. (2019) (70)
- De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. (2001) (70)
- Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR. (2017) (69)
- Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. (2016) (69)
- Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. (2012) (69)
- A de novo designed protein shows a thermally induced transition from a native to a molten globule-like state (1992) (69)
- Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores. (2007) (68)
- pH-induced conformational change of the influenza M2 protein C-terminal domain. (2008) (68)
- Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR. (2013) (68)
- Aminothiotyrosine Disulfide, an Optical Trigger for Initiation of Protein Folding (1997) (68)
- Blue fluorescent amino acid for biological spectroscopy and microscopy (2017) (67)
- Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design: Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases (1996) (67)
- Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo (2001) (67)
- Thermodynamic analysis of a designed three-stranded coiled coil. (1996) (67)
- Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane (2012) (66)
- Computationally designed peptide inhibitors of protein-protein interactions in membranes. (2008) (66)
- Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides (1997) (66)
- Use of 2,2′-dithiobis(5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group (1996) (66)
- Amino Acid Propensities are Position-dependent Throughout the Length of α-Helices (2004) (66)
- Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. (2011) (66)
- Acid activation mechanism of the influenza A M2 proton channel (2016) (65)
- Noncovalent self-assembly of a heterotetrameric diiron protein (2002) (65)
- Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment (2011) (64)
- Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure. (2015) (64)
- Design of two-stranded and three-stranded coiled-coil peptides. (1995) (64)
- NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation (2010) (63)
- Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. (2018) (63)
- Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding. (2012) (63)
- Molecular Motions and Protein Folding: Characterization of the Backbone Dynamics and Folding Equilibrium of α2D Using13C NMR Spin Relaxation (2000) (63)
- Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides. (2004) (63)
- The membrane- and soluble-protein helix-helix interactome: similar geometry via different interactions. (2015) (62)
- High-density grids for efficient data collection from multiple crystals (2016) (62)
- A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis. (2009) (62)
- Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion (2008) (61)
- Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein (2002) (61)
- The design and evaluation of heparin-binding foldamers. (2005) (60)
- Stimulated Photon Echoes from Amide I Vibrations (1999) (60)
- Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics. (2006) (59)
- Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore. (2013) (59)
- Exploration of the structural features defining the conduction properties of a synthetic ion channel. (1999) (59)
- Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5 (2011) (59)
- Site-specific hydration status of an amphipathic peptide in AOT reverse micelles. (2007) (59)
- The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. (2008) (59)
- A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. (1994) (59)
- Solid-phase synthesis of a selective αvβ3 integrin antagonist library (1997) (59)
- Long-range interactions stabilize the fold of a non-natural oligomer. (2002) (59)
- Designed metalloprotein stabilizes a semiquinone radical. (2016) (59)
- Preorganization of molecular binding sites in designed diiron proteins (2003) (58)
- Analysis and design of turns in alpha-helical hairpins. (2005) (58)
- Nature-inspired design of motif-specific antibody scaffolds (2013) (57)
- De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. (2004) (57)
- XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction (2017) (57)
- Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions (2017) (56)
- Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus (2014) (56)
- Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. (2004) (56)
- Tertiary templates for the design of diiron proteins. (1999) (55)
- Computational design of a β-peptide that targets transmembrane helices. (2011) (55)
- Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. (2005) (55)
- Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. (2010) (55)
- Sequence and structural homologies among type I and type II interferons (1982) (55)
- Inhibition of integrin α2β1 ameliorates glomerular injury. (2012) (55)
- The design, synthesis, and characterization of tight‐binding inhibitors of calmodulin (1985) (55)
- Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. (1984) (54)
- Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays. (2008) (54)
- Protein-directed self-assembly of a fullerene crystal (2016) (54)
- Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals (2012) (54)
- Activation of Platelet αIIbβ3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of αIIb*> (2006) (53)
- De novo protein design: what are we learning? (1991) (53)
- Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay (2010) (53)
- In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments (2019) (53)
- Role of the conformational rigidity in the design of biomimetic antimicrobial compounds. (2010) (52)
- Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides. (2006) (51)
- Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. (2011) (51)
- A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. (2017) (50)
- Characterization of the structural properties of .alpha.1B, a peptide designed to form a four-helix bundle (1992) (50)
- Proton and metal ion‐dependent assembly of a model diiron protein (2001) (50)
- Modeling transmembrane helical oligomers. (1997) (49)
- Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay (2013) (49)
- Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. (2016) (48)
- Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus* (2008) (48)
- Designed peptides that assemble into cross-α amyloid-like structures (2018) (48)
- Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. (2011) (48)
- Analysis and design of three-stranded coiled coils and three-helix bundles. (1998) (47)
- Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. (2002) (47)
- Peptide models for the membrane destabilizing actions of viral fusion proteins (1992) (47)
- Use of phage display to probe the evolution of binding specificity and affinity in integrins. (2003) (47)
- Determination of membrane protein stability via thermodynamic coupling of folding to thiol–disulfide interchange (2003) (47)
- Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist. (1996) (47)
- Molecular Basis of ChvE Function in Sugar Binding, Sugar Utilization, and Virulence in Agrobacterium tumefaciens (2009) (46)
- Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry (2018) (46)
- The interaction of calmodulin with fluorescent and photoreactive model peptides: Evidence for a short interdomain separation (1989) (46)
- Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers. (2007) (46)
- Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production. (1998) (45)
- Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations. (2007) (45)
- Sliding helix and change of coordination geometry in a model di-MnII protein. (2003) (45)
- The helix-forming propensity of D-alanine in a right-handed .alpha.-helix (1992) (45)
- Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. (2009) (45)
- D(n)-symmetrical tertiary templates for the design of tubular proteins. (2001) (45)
- A Designed Buried Salt Bridge in a Heterodimeric Coiled Coil (1997) (45)
- Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ (2010) (44)
- 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. (2013) (44)
- Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations (2013) (44)
- Novel nonpeptide antiplatelet glycoprotein llb/llla receptor antagonist, DMP754: receptor binding affinity and specificity (1996) (44)
- Deep Mutational Scanning Reveals the Structural Basis for α-Synuclein Activity (2020) (44)
- Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. (2010) (43)
- Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. (2019) (43)
- Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography. (2005) (42)
- Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. (2001) (42)
- Association of a model transmembrane peptide containing gly in a heptad sequence motif. (2004) (42)
- Diiron-containing metalloproteins: Developing functional models (2007) (42)
- Computational design of a water‐soluble analog of phospholamban (2003) (42)
- De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. (2003) (41)
- A polar, solvent-exposed residue can be essential for native protein structure. (2000) (41)
- Investigation of an unnatural amino acid for use as a resonance Raman probe: Detection limits, solvent and temperature dependence of the νC≡N band of 4-cyanophenylalanine. (2008) (40)
- An M2‐V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine‐sensitive and ‐resistant influenza A viruses (2017) (40)
- Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy. (2010) (40)
- T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. (2005) (39)
- De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures (2017) (39)
- Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. (2008) (39)
- From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin. (1998) (38)
- Experimental and computational evaluation of forces directing the association of transmembrane helices. (2009) (38)
- Crystal structure of the drug‐resistant S31N influenza M2 proton channel (2016) (37)
- Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. (2017) (37)
- Recognition and characterization of calmodulin-binding sequences in peptides and proteins. (1987) (37)
- A predicted structure of calmodulin suggests an electrostatic basis for its function. (1985) (37)
- Proteins from Scratch (1997) (36)
- Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors. (2011) (36)
- Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function. (2007) (36)
- Characterization of the Dizinc Analogue of the Synthetic Diiron Protein DF1 Using ab Initio and Hybrid Quantum/Classical Molecular Dynamics Simulations (2003) (35)
- A defined structural unit enables de novo design of small-molecule–binding proteins (2020) (35)
- Constructing ion-channels from water-soluble α–helical barrels (2021) (35)
- The leech product saratin is a potent inhibitor of platelet integrin α2β1 and von Willebrand factor binding to collagen (2007) (34)
- The design of a four-helix bundle protein. (1987) (34)
- De novo design of heterotrimeric coiled coils (1996) (34)
- Small Molecule Inhibitors of Integrin α2β1 (2007) (34)
- Evolution of binding affinity in a WW domain probed by phage display (2000) (34)
- Arylamide derivatives as peptidomimetic inhibitors of calmodulin. (2006) (33)
- Thermodynamic genetics of the folding of the B1 immunoglobulin‐binding domain from streptococcal protein G (1995) (33)
- Infrared signature and folding dynamics of a helical beta-peptide. (2010) (33)
- Hydrophobic core malleability of a de novo designed three-helix bundle protein. (2001) (33)
- Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of CaV Function (2017) (33)
- Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. (2003) (33)
- Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study. (2006) (32)
- Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers. (2004) (32)
- Polar networks control oligomeric assembly in membranes. (2006) (32)
- Posttranslational modification of human T-cell growth factor. (1983) (32)
- Two models of the influenza A M2 channel domain: verification by comparison. (1998) (32)
- Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. (1997) (32)
- Centrosymmetric bilayers in the 0.75 å resolution structure of a designed alpha‐helical peptide, D, L‐Alpha‐1 (1999) (32)
- Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. (2005) (31)
- Predicted calmodulin‐binding sequence in the γ subunit of phosphorylase b kinase (1987) (31)
- Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-jump/UV Raman spectroscopy. (2007) (30)
- Development of a rotamer library for use in beta-peptide foldamer computational design. (2010) (30)
- De Novo Design of Self-Assembling Foldamers That Inhibit Heparin–Protein Interactions (2014) (30)
- Metal-binding dependent disruption of membranes by designed helices. (2009) (30)
- Computational design of a self-assembling β-peptide oligomer. (2010) (29)
- X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils. (2005) (29)
- Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors. (2015) (29)
- De novo design, synthesis, and characterization of antimicrobial beta-peptides. (2001) (29)
- The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. (2000) (29)
- Engineering photosynthesis: synthetic redox proteins (1996) (29)
- The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. (2006) (29)
- Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops (2005) (29)
- A hierarchic approach to the design of hexameric helical barrels. (2002) (29)
- Structural basis for integrin alphaIIbbeta3 clustering. (2004) (29)
- Amino acid propensities are position-dependent throughout the length of alpha-helices. (2004) (28)
- Graphene Symmetry Amplified by Designed Peptide Self-Assembly (2016) (28)
- Resin-to-Resin Acyl- and Aminoacyl-Transfer Reactions Using Oxime Supports (1999) (28)
- Multiple Proton Confinement in the M2 Channel from the Influenza A Virus. (2010) (28)
- Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. (1998) (28)
- Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. (2006) (28)
- De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. (2017) (28)
- Oxygen reactivity of the biferrous site in the de novo designed four helix bundle peptide DFsc: nature of the "intermediate" and reaction mechanism. (2008) (28)
- Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins (2012) (27)
- Cooperativity and specificity of association of a designed transmembrane peptide. (2002) (26)
- Macrocyclic amino carboxylates as selective MMP-8 inhibitors. (1998) (26)
- Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus. (2013) (26)
- Engineered single- and multi-cell chemotaxis pathways in E. coli (2009) (26)
- Mutagenesis data in the automated prediction of transmembrane helix dimers (2007) (26)
- Spectroscopic definition of the biferrous and biferric sites in de novo designed four-helix bundle DFsc peptides: implications for O2 reactivity of binuclear non-heme iron enzymes. (2009) (26)
- Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. (2009) (26)
- De novo design, synthesis and characterization of membrane-active peptides. (2001) (26)
- α‐α linking motifs and interhelical orientations (2005) (26)
- Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. (1986) (25)
- Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. (2000) (24)
- Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins. (2015) (24)
- The Design of Efficient α-Helical C-Capping Auxiliaries (1998) (24)
- A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. (2010) (23)
- Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. (2015) (23)
- Catalytic molten globules (1993) (23)
- The role of helix formation in the folding of a fully alpha-helical coiled coil. (1996) (23)
- Simulated evolution of emergent chiral structures in polyalanine. (2004) (23)
- Light-induced helix formation. (2002) (23)
- Allosteric cooperation in a de novo-designed two-domain protein (2020) (23)
- 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. (2014) (23)
- Design, synthesis and in vitro activities of a series of benzimidazole/benzoxazole glycoprotein IIb/IIIa inhibitors (1996) (23)
- Introduction: protein design. (2001) (22)
- Disulfide crosslinks to probe the structure and flexibility of a designed four‐helix bundle protein (1994) (22)
- Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion. (2005) (22)
- Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering* (2016) (22)
- Computational design of heterochiral peptides against a helical target. (2006) (22)
- The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets* (2015) (22)
- Photoactivatable protein labeling by singlet oxygen mediated reactions. (2016) (21)
- Determination of the physiological dimer interface of the PhoQ sensor domain. (2008) (21)
- The accommodation index measures the perturbation associated with insertions and deletions in coiled‐coils: Application to understand signaling in histidine kinases (2017) (21)
- Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M 2 (2011) (21)
- Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices. (2010) (21)
- Hydrogen Bonded Cluster Can Specify the Native State of a Protein (2000) (20)
- Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation. (2015) (20)
- Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: Identification of αvβ3 antagonists lead compounds (1999) (20)
- Alpha-alpha linking motifs and interhelical orientations. (2005) (20)
- A one-dimensional free energy surface does not account for two-probe folding kinetics of protein alpha(3)D. (2009) (19)
- Detection of drug‐induced conformational change of a transmembrane protein in lipid bilayers using site‐directed spin labeling (2013) (19)
- Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel. (2011) (19)
- Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. (2003) (19)
- Activation of Individual αIIbβ3 Integrin Molecules by Disruption of Transmembrane Domain Interactions in the Absence of Clustering (2006) (19)
- Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus. (2018) (19)
- Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport (2017) (18)
- Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. (2016) (18)
- Introduction of a Trp residue into .alpha.4 as a probe of dynamics (1993) (18)
- De novo design of a transmembrane Zn[superscript 2+]-transporting four-helix bundle (2014) (18)
- Identification of Interacting Hot Spots in the β3 Integrin Stalk Using Comprehensive Interface Design* (2010) (18)
- Computational biology: Biosensor design (2003) (18)
- The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. (2007) (18)
- Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity. (2018) (18)
- Development of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinase (1980) (17)
- A general method for coupling unprotected peptides to bromoacetamido porphyrin templates (1994) (17)
- De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban. (2005) (17)
- Arylamide derivatives as allosteric inhibitors of the integrin α2β1/type I collagen interaction (2006) (17)
- Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid. (1997) (17)
- Proton Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. (2019) (17)
- Targeting integrin &agr;5&bgr;1 ameliorates severe airway hyperresponsiveness in experimental asthma (2016) (17)
- Novel synthesis of N a -methyl-arginine and N a -methyl-ornithine derivatives (1995) (17)
- SNAC-tag for Sequence-specific Chemical Protein Cleavage (2019) (17)
- Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids. (2011) (16)
- Native-like and structurally characterized designed alpha-helical bundles. (1995) (16)
- Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins. (2015) (16)
- Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. (2009) (16)
- A long‐lived Aβ oligomer resistant to fibrillization (2018) (15)
- Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide (2004) (15)
- Use of Synthetic Peptides for the Study of Membrane Protein Structure (1994) (14)
- Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity (2010) (14)
- Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability. (2005) (14)
- Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. (2006) (14)
- Proton Release from the Histidine-Tetrad in the M2 Channel of the Influenza A Virus (2014) (14)
- Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular Simulations (2013) (14)
- X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance. (2020) (13)
- Fmoc-based synthesis of glycolate ester peptides for the assembly of de novo designed multimeric proteins using subtiligase (1996) (13)
- Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. (2016) (13)
- The Flu's Proton Escort (2010) (13)
- Design of a Short Thermally Stable α‐Helix Embedded in a Macrocycle (2018) (13)
- Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics (2020) (13)
- Design of a Synthetic Receptor for the Calmodulin-Binding Domain of Calcineurin (1997) (13)
- Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. (2001) (13)
- Design of Peptides and Proteins (1989) (13)
- X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. (2019) (13)
- Seismic Imaging of Transition Zone Discontinuities Suggests Hot Mantle West of Hawaii (2011) (12)
- C‐terminal juxtamembrane region of full‐length M2 protein forms a membrane surface associated amphipathic helix (2015) (12)
- Identification of recognition sequences of adhesion molecules using phage display technology. (1994) (12)
- Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy. (2021) (12)
- Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. (2019) (12)
- Automated use of mutagenesis data in structure prediction (2005) (12)
- Protein minimization: downsizing through mutation. (1996) (12)
- Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly (2014) (12)
- Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. (2020) (12)
- Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study. (2019) (11)
- Probing Structural Dynamics of Individual Calmodulin:Peptide Complexes in Hydrogels by Single-Molecule Confocal Microscopy (2004) (11)
- Structural Stability and Binding Strength of a Designed Peptide-Carbon Nanotube Hybrid. (2013) (11)
- De novo metalloprotein design (2021) (11)
- Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster (2018) (11)
- Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron (2014) (11)
- De novo design of a homo-trimeric amantadine-binding protein (2019) (11)
- A Real-Time All-Atom Structural Search Engine for Proteins (2014) (10)
- Prion biology: implications for Alzheimer's disease therapeutics (2020) (10)
- The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil. (2010) (10)
- Rotational orientation of monomers within a designed homo‐oligomer transmembrane helical bundle (2005) (10)
- Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy. (2017) (10)
- Crystallization of proton channel peptides (1992) (10)
- Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell (2022) (10)
- Role for the Integrin 2 1 in Experimental and Developmental Angiogenesis (2009) (10)
- Small molecule inhibitors of integrin alpha2beta1. (2007) (10)
- Assessment of local friction in protein folding dynamics using a helix cross-linker. (2013) (9)
- An Efficient Synthesis of Glycoprotein IIb/IIIa Inhibitor DMP728. A Novel Synthesis of N.alpha.-Methylarginine-Containing Peptide (1995) (9)
- Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. (2018) (9)
- Modest membrane hydrogen bonds deliver rich results. (2008) (9)
- Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. (2006) (9)
- X‐ray grade crystals of a designed α‐helical coiled coil (1992) (9)
- Cysteine‐linked aromatic nitriles as UV resonance Raman probes of protein structure (2012) (9)
- A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion (2019) (9)
- De novo designed transmembrane peptides activating the &agr;5&bgr;1 integrin (2018) (8)
- DESIGNED TRIMERIC COILED COIL-VALD (1997) (8)
- Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. (2019) (8)
- Structural consequences of an amino acid deletion in the B1 domain of protein G (2000) (8)
- De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. (2020) (8)
- The Twists and Turns of β‐Peptides (2010) (7)
- Potent matrix metalloproteinase inhibitors: Amino-carboxylate compounds containing modifications of the P1 residue (1996) (7)
- The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling (2022) (7)
- Analytical ultracentrifugation studies of the influenza M2 homotetramerization equilibrium in detergent solutions (2006) (7)
- Design and synthesis of simplified energy-converting proteins. (1994) (7)
- Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. (2021) (6)
- Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies. (1984) (6)
- Synthesis and antiplatelet activity of DMP 757 analogs (1995) (6)
- Carbon-13 enriched S-methyl probe at the active site of an enzyme: [S-[13C]methylmethionine-192]-.alpha.-chymotrypsin (MSMC) (1980) (6)
- Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. (2006) (6)
- Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ (2022) (6)
- An Assay Suitable for High Throughput Screening of Anti-Influenza Drugs (2013) (5)
- Slow folding-unfolding kinetics of an octameric β-peptide bundle. (2014) (5)
- Calmodulin binding to α1‐purothionin: Soloution binding and modeling of the complex (1992) (5)
- 4-Cyanoindole-2′-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics (2019) (5)
- Nanosecond Dynamics of InfluenzaA/M2TM and an Amantadine Resistant Mutant Probed by Time-Dependent Red Shifts of a Native Tryptophan. (2013) (5)
- Expression of de novo designed alpha-helical bundles. (1996) (5)
- Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein. (2014) (4)
- Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Inter-subunit Contacts. (2019) (4)
- Peptide engineering. Catalytic molten globules. (1993) (4)
- Lipid membranes supported on optically transparent nanosilicas: synthesis and application in characterization of protein-membrane interactions. (2011) (4)
- Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction (2021) (4)
- Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function (2019) (4)
- Design of a heme-binding four helix bundle (1993) (4)
- Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site. (2021) (4)
- Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding (2020) (4)
- Cover Picture: Nontoxic Membrane‐Active Antimicrobial Arylamide Oligomers (Angew. Chem. Int. Ed. 9/2004) (2004) (4)
- Design and synthesis of polytripeptide (leuglnpro)n based upon the matrix protein amelogenin (1994) (4)
- Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome (2021) (4)
- Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides (2022) (3)
- Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ (2021) (3)
- Brilacidin, a COVID-19 Drug Candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E and NL63 through targeting both the virus and the host cell (2021) (3)
- Phage Display of Random Peptides on a Protein Scaffold (1994) (3)
- Activation of the platelet integrin alphaIIbbeta3 by thermodynamic modulation of transmembrane helix associations (2003) (3)
- Design of a 4-Helix Bundle Protein: Synthesis of Peptides Which Self-Associate into a Helical Protein. (1988) (3)
- A New Design of Coiled-Coil Helix Bundle Peptide-Polymer Conjugates (2008) (3)
- Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness. (2020) (3)
- Interactions of ADP-stimulated human platelets with PEGylated polystyrene substrates prepared by surface amidation. (2007) (3)
- Conformationally constrained alpha-helical peptide models for protein ion channels. (1990) (3)
- Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments (2022) (2)
- Towards Design of Novel Antimicrobial Agents: Role of the Conformational Rigidity (2010) (2)
- Stabilities of coiled-coil dimers as a model for leucine zippers (1992) (2)
- Optimized Fully-Synthetic Salicylamide Heparin Antagonists Have Greater Efficacy Versus LMWHs and Display Improved Hemodynamic Responses as Compared to Protamine (2010) (2)
- Emerging In Vivo Analyses of Cell Function Using Fluorescence Imaging ∗ (2011) (2)
- Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA (2021) (2)
- Correction for Thomaston et al., High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction (2016) (2)
- Exposing the Nucleation Site of Alpha Helix Folding: A Joint Experimental and Simulation Study (2019) (2)
- Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase. (1987) (2)
- Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior (2021) (2)
- A photon-free approach to transmembrane protein structure determination. (2011) (2)
- SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers (2022) (2)
- Interaction of sTREM2 with Amyloid Beta: Implication on the Protective Role of sTREM2 in Alzheimer’s Disease (2020) (2)
- Titelbild: The Design and Evaluation of Heparin-Binding Foldamers (Angew. Chem. 41/2005) (2005) (2)
- Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides. (2021) (2)
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits (2021) (2)
- Erratum: Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β 3-amino acids (Organic Letters (3475)) (2012) (1)
- De Novo Design of Helical Proteins (1993) (1)
- Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. (1999) (1)
- SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D) (1999) (1)
- Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein—Protein Interactions (2009) (1)
- Induction of Peptide Conformation at Apolar/Water Interfaces. Part 1. (1986) (1)
- Aβ and Tau Prions Causing Alzheimer's Disease. (2023) (1)
- The S31N mutant of the influenza A M2 proton channel in two distinct conformational states (2019) (1)
- Designer Peptides Self-Assemble on Graphene to Create Remarkably Stable, Precisely Organized Substrates (2017) (1)
- Inside Cover: Design of a Three‐Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment (Angew. Chem. Int. Ed. 9/2011) (2011) (1)
- De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures (2017) (1)
- Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors (2020) (1)
- In memorium: Emil Thomas Kaiser, 1938–1988 (1988) (1)
- Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity (2017) (1)
- Synthetic A beta prion strains producing distinct amyloid deposits in the brains of transgenic mice (2014) (1)
- A Conserved Transmembrane Domain Interface Regulates Integrin Function (2008) (1)
- The Interplay of Thermodynamic Stability, Functional Tuning, and Drug Resistance in the Evolution of the M2 Proton Channel From the Influenza A Virus (2008) (1)
- Endothelial cell_collagen interactions in angiogenesis (2006) (1)
- Structural analysis of a de novo designed metalloprotein (2003) (1)
- Towards the de novo Design of Functional Metalloproteins (2020) (1)
- Influenza A M2 proton channel wild type TM domain bound to S-rimantadine (2020) (1)
- Computational Design of a Model for the Platelet Integrin αIIbβ3. (2006) (1)
- Membrane Fusion Activity of Influenza Virus and Reconstituted Viral Envelopes (Virosomes) (1991) (1)
- Track A Basic Science (2012) (1)
- Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors. (2013) (1)
- Deciphering Regulatory Mechanism of the Juxtamembrane Region in Thrombopoietin Receptor Activation (2014) (1)
- Fibrinogen receptor antagonists isoxazoline and isoxazole. (1994) (1)
- Regulation of the Function of αvβ3 in Platelets by a Designed Peptide Targeting the αv Transmembrane Domain. (2006) (1)
- Antimicrobial synthetic polymers: Amphiphilic polymethacrylate derivatives (2004) (1)
- 2SD06 Computational design of water-soluble analogues of the potassium channel KcsA (2004) (1)
- Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid. (2021) (1)
- The Protocol for SNAC-tag Chemical Protein Cleavage (2019) (1)
- Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. (2021) (1)
- The Role a-Helical of Helix Formation in the Folding of a Fully Coiled Coil (1996) (1)
- THE LEECH PRODUCT SARATIN IS A POTENT INHIBITOR OF PLATELET INTEGRIN ALPHA2BETA1 AND VWF BINDING TO COLLAGEN (2007) (0)
- Roles of Hydrogen-Bonding Networks in Proton Channel Function as Revealed through de novo Designed Proton Channels (2020) (0)
- X-ray crystal structures of the influenza A M2 proton channel bound to amantadine, rimantadine and inhibiting compounds (2017) (0)
- Assessing the Biochemistry of Kindlin-3 In Human Platelets (2010) (0)
- Editor's Note (0)
- Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide (2013) (0)
- Crystallization of a designed peptide from a molten globule ensemble. (1996) (0)
- NMR Structure of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer (2008) (0)
- Erratum (0)
- EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains (2023) (0)
- CORRECTION (2006) (0)
- SNAC-tag for sequence-specific chemical protein cleavage (2019) (0)
- Remorino Transmembrane Helix Dimer Residue-Specific Vibrational Echoes Yield 3 D Structures of a (2014) (0)
- Transient Water Wires Mediate Selective Proton Transport in Designed Channel Proteins (2022) (0)
- Dedication to Emil T. Kaiser and Irving S. Sigal (1990) (0)
- The Leech Product Saratin Is a Potent Inhibitor of Both VWF and Integrin α2β1 Binding to Collagen. (2006) (0)
- Protein-Protein and Protein-Lipid Interactions Modulate αIIbβ3 Inside-out Signaling. (2009) (0)
- Influenza A M2 proton channel wild type TM domain bound to R-rimantadine (2020) (0)
- United States Patent DeGrado (2017) (0)
- Novel Synthesis of Nα-Methyl-arginine and Nα-Methyl- ornithine Derivatives. (1995) (0)
- Integrin αIIbβ3-Mediated c-Src Activation: Differential Binding to Inactive and Active c-Src (2014) (0)
- Multi-state modeling of the PhoQ two-component system (2014) (0)
- De Novo Design of Cross-α Amyloid-Like Fibrils with Cellular Activity (2018) (0)
- Communication: General Principles and Lessons from the Structure and Function of (2011) (0)
- Crystal Structure of the Computationally Designed Transmembrane Metallotransporter with 4-bromophenylalanine in Lipidic Cubic Phase (2014) (0)
- Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion. (2021) (0)
- Structural basis of adamantane resistance in the influenza A M2 proton channel (2019) (0)
- The two-dimensional IR nonlinea penta-peptide in relation to its tl (2016) (0)
- Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation (2018) (0)
- De novo design of self-assembling foldamers that inhibit heparin-protein interactions - eScholarship (2014) (0)
- Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor (2018) (0)
- CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc-gamma receptor signaling in natural killer cells (2022) (0)
- Solution structure of a diiron protein model: Due Ferri(II) turn mutant (2005) (0)
- Reversibility of Amantadine Inhibition in the M2 Proton Channel of Influenza A Virus (2009) (0)
- 2D IR measurements of the coupling in transmembrane helix dimers (2006) (0)
- Activation of Platelet α Iibβ 3 by Exogenous Peptides Corresponding to the Transmembrane Domains of α Iib and β 3. (2005) (0)
- Inhibition of Integrin a 2 b 1 Ameliorates Glomerular Injury (2012) (0)
- Solution NMR structure of Diiron protein in presence of 2 eq Zn2+, Northeast Structural Genomics Consortium Target OR21 (2011) (0)
- Expression of de novo Designed α‐Helical Bundles (1996) (0)
- Calmodulin, C-terminal domain, F92E mutant (2011) (0)
- Analysis of β3 Binding to the c-Src SH3 Domain (2012) (0)
- Characterization of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer by NMR. (2007) (0)
- Three-Dimensional Structure of Full Length Integrin Embedded in Membrane (0)
- XFEL structure of influenza A M2 wild type TM domain at intermediate pH in the lipidic cubic phase at room temperature (2017) (0)
- Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor (2020) (0)
- Controlled Fabrication of Nanogaps for Molecular Electronics (2005) (0)
- 1H Chemical Shift Assignments and Interproton 3JHNHA Coupling Constants of Alpha2-D, a Nativelike de Novo Designed Four Helix Bundle (2008) (0)
- INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 BASED ON PROLYL (2017) (0)
- SOLUTION STRUCTURE OF ALPHA2D (1999) (0)
- Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions (2017) (0)
- Characterizing insertions in coiled coil proteins (2017) (0)
- Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under cryo diffraction conditions (2015) (0)
- Activation of Platelet (cid:1) IIb (cid:2) 3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of (cid:1) IIb * □ (2006) (0)
- Infrared Signature and Folding Dynamics of a Helical (cid:1) -Peptide (2010) (0)
- Species differences in small molecule binding to (cid:1) IIb (cid:2) 3 are the result of sequence differences in 2 loops of the (cid:1) IIb (cid:2) propeller (2009) (0)
- Contributions of chemistry: biotechnology and materials science. (1989) (0)
- Factors That Influence the Homo- and Hetero-Oligomerization of the Leukocyte Integrin Transmembrane Domains (2008) (0)
- De novo design of functional Mn-porphyrin binding proteins (2022) (0)
- Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton (2018) (0)
- Influenza A M2 transmembrane domain drug-resistant S31N mutant at pH 8.0 (2016) (0)
- Het-N2-SO3- - De novo designed three-helix heterodimer with Cysteine S-sulfate at the N2 position of the alpha-helix (2021) (0)
- The delicate balance between apolar packing and hydrogen bonding determines membrane protein assembly and function (2022) (0)
- Cover Picture: Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure (Eur. J. Inorg. Chem. 21/2015) (2015) (0)
- Small molecule inhibitors of collagen-induced angiogenesis (2008) (0)
- Selection of improved peptide ligases by yeast surface display (2012) (0)
- Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndrome (2021) (0)
- CaV beta2a subunit: CaV1.2 AID-CAP complex (2017) (0)
- Crystal Structure of De novo Designed Fullerene organizing peptide (2016) (0)
- Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides. (2005) (0)
- Iconography : Diiron-containing metalloproteins: Developing functional models (2008) (0)
- Arylamides: Discovery of a Novel Class of Fully-Synthetic Small Molecule Heparin and LMWH Antagonists. (2010) (0)
- X-Ray Crystal Structures of the Influenza a M2 Proton Channel Bound to Amantadine, Rimantadine, and Inhibiting Compounds (2018) (0)
- Mapping Water Density to Design New Blockers Against a Viral Proton Channel (2012) (0)
- Apo structure of phosphotyrosine (pYAb) scaffold (2013) (0)
- The Design and Synthesis of Small Molecule Inhibitors of Collagen Binding to Integrin α2β1 as Antithrombotic Agents. (2007) (0)
- Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under room temperature diffraction conditions (2015) (0)
- Computational Design of Helical Peptides Targeting Transmembrane Domain of Cellular Receptors (2016) (0)
- De novo designed two-domain di-Zn(II) and porphyrin-binding protein (2020) (0)
- Association of Transmembrane Helices in Viral Fusion Peptides Suggests a Protein-Centric Mechanism of Membrane Fusion (2011) (0)
- Solution structure of a four-helix bundle model, apo-DF1 (2003) (0)
- Crystal Structure of the Computationally Designed Transmembrane Metallotransporter with 4-bromophenylalanine in Octyl Glucoside (2014) (0)
- Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation (2011) (0)
- Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome (2021) (0)
- De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-1 (2019) (0)
- A novel class of Calmodulin mimetics: De Novo designed proteins in molecular recognition (2002) (0)
- XFEL structures of the influenza M2 proton channel at 1.4 Å: room-temperature water networks and insights into proton conduction (2017) (0)
- Proton Stabilization and Conduction Pathway in the Matrix Protein M2 (2018) (0)
- The structure of a designed peptide refined to 2.1 Å resolution (1996) (0)
- PL5, synthetic transmembrane domain variant of human phospholamban (2019) (0)
- Cover Picture: The Design and Evaluation of Heparin‐Binding Foldamers (Angew. Chem. Int. Ed. 41/2005) (2005) (0)
- NCBS SYMPOSIUM ON MOLECULES, MACHINES AND NETWORKS (2003) (0)
- De Novo Design of Polynuclear Transition Metal Clusters in Helix Bundles-4DH1 (2018) (0)
- Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct (2020) (0)
- High resolution crystal structure of transmembrane domain of M2 (2010) (0)
- Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology (2023) (0)
- Crystal Structure of De novo Designed helical assembly protein (2011) (0)
- Structural studies of designed alpha-helical hairpins (2005) (0)
- QM/MM structure refined from NMR-structure of a single chain diiron protein (2007) (0)
- Differential Stability of CaVβ2a and CaVβ3 in a CaV1.2 Calcium Channel Complex (2014) (0)
- DESIGNED PEPTIDE ALPHA-1, RACEMIC P1BAR FORM (1998) (0)
- Protein function, folding, and dynamics in the proteinomic era (2003) (0)
- NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11 (2014) (0)
- Engineering and design: editorial overview. (2009) (0)
- CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER (2001) (0)
- Use of De Novo Designed Peptides for the Study of Metalloproteins and Enzymes (1995) (0)
- Structure and Inhibition of the M2 Proton Channel from the Influenza a Virus (2014) (0)
- Contributions of Chemistry. (Book Reviews: Biotechnology and Materials Science) (1989) (0)
- Innentitelbild: Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment (Angew. Chem. 9/2011) (2011) (0)
- Crystal structure of a water soluble analog of phospholamban (2005) (0)
- Biopolymers: Modulation of nucleic acids, carbohydrates and proteins to different task (1999) (0)
- Design, synthesis and characterization of DNA binding peptides (1992) (0)
- Structure of phosphoserine (pSAb) scaffold bound to pSer peptide (2013) (0)
- Monitoring Proton Flux Quantitatively; Influenza Proton Channel A/M2 (2010) (0)
- Phasing by maximal-minimal non-isomorphic sub-super-groups relationship in four-helix bundle designed protein (2002) (0)
- EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains (2023) (0)
- Biopolymers: Multifaceted biopolymers (2002) (0)
- Supplemental Information Graphene Symmetry Ampli fi ed by Designed Peptide Self-Assembly (2016) (0)
- SPECIFICITY FOR HOMO-VERSUS HETERO-OLIGOMER FORMATION IN INTEGRIN TRANSMEMBRANE HELICES (2011) (0)
- Activating Individual αIIbβ3 Molecules Using An Anti-αIIb-Transmembrane Domain Peptide Causes αIIbβ3 Oligomerization and αIIbβ3-Mediated Outside-In Signaling (2013) (0)
- De novo design of a β-lactamase in a modular helical bundle protein scaffold (2022) (0)
- Cross-alpha Amyloid-like Structure alphaAmL, 2nd form (2019) (0)
- Characterization of the Weak Interaction of C-Src with the β3 Cytoplasmic Tail (2008) (0)
- Heteromeric and Homomeric Transmembrane Domain Associations Regulate αIIbβ3 Function. (2004) (0)
- Solution structure of a diiron protein model (2005) (0)
- Promotion of the neutralization-competent structure of the HIV-1 gp41 membrane proximal external region when tethered to its native transmembrane domain, and expressed in the context of the plasma membrane: implications for vaccine design (53.24) (2011) (0)
- Crystallographically Characterized De Novo Designed Mn-Diphenylporphyrin Binding Protein (2021) (0)
- Het-Ncap - De novo designed three-helix heterodimer with Cysteine at the Ncap position of the alpha-helix (2021) (0)
- A designed pentameric membrane protein stabilized by van der Waals interaction (2019) (0)
- Contributions of Chemistry: Biotechnology and Materials Science : Chemistry for the Future. Mary L. Good et al. , Eds. American Chemical Society, Washington, DC, 1988. xx, 135 pp., illus. $24.95; paper, $14.95. (1989) (0)
- Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats (2023) (0)
- Identification of Oligomerization Motifs in the β3 Transmembrane Domain. (2007) (0)
- Testing the Structural Mechanism of Transmembrane Translocation using De-Novo Designed Soft-Metal Transporters with Inverted Dual Topology (2012) (0)
- Bioorganic Models for Protein Ion Channels (1991) (0)
- Transmembrane Helices Computational Design of Peptides That Target (2007) (0)
- Het-N2 - De novo designed three-helix heterodimer with Cysteine at the N2 position of the alpha-helix (2021) (0)
- Factors Influencing the Homomeric and Heteromeric Association of Platelet Integrin Transmembrane Domains. (2006) (0)
- ssNMR structure of a designed rocker protein (2014) (0)
- Determining the Functional Core for Proton Transport, Ion Selectivity and Amantadine Sensitivity of the A/M2 Protein from Influenza A Virus (2009) (0)
- A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi (2022) (0)
- Cover Feature: Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle (ChemBioChem 9/2018) (2018) (0)
- Isoxazolin and isozazol fibrinogen (1994) (0)
- Engineering and design: Expanding the protein world (2004) (0)
- Analysis and design of ion channel proteins (1997) (0)
- Succinate-based TNF-alpha convertase inhibitors 5-Azabenzimidazole as a surrogate of the amide bond at P3 (1998) (0)
- Lear homo-oligomeric helical bundles membrane proteins ? Perspectives from the study of How do helix – helix interactions help determine the folds of (2003) (0)
- Molecular Design and X-Ray Crystal Structure of Engineered Phospholamban Transmembrane Variant (2018) (0)
- NOVEL SYNTHESIS OF NALPHA -METHYL-ARGININE AND NALPHA -METHYL-ORNITHINE DERIVATIVES (1995) (0)
- Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. (1992) (0)
- Computational Design of Transmembrane Peptides that Bind and Inhibit the Erythropoietin Receptor (2020) (0)
- A new look for the RLBL Newsletter (2002) (0)
- Structural characterization of adamantane-resistant mutants of the influenza M2 proton channel (2018) (0)
- Crystal structure of the periplasmic sugar binding protein ChvE (2012) (0)
- Real-Time Characterization of an Antimicrobial Mechanism-of-Action with Nonlinear Optical Scattering (2017) (0)
- Artificial Diiron Enzymes with a de novo Designed Four-Helix Bundle Structure (2015) (0)
- Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide (2013) (0)
- Proton/ion co-transport by protein M2 of influenza virus A (2010) (0)
- Crystal Structure of the Computationally Designed Transmembrane Metallotransporter in Octyl Glucoside (2014) (0)
- Influenza A M2 transmembrane domain bound to amantadine (2018) (0)
- Facially amphiphilic polymers as an anti-infective agents (2002) (0)
- Identification of Stalk Mutations That Stabilize the High Affinity Conformation of αIIbβ3 by Negative Design. (2009) (0)
- Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine (2010) (0)
- The use of neuromagnetism to evaluate normal and abnormal neurological function (2006) (0)
- Mantle West of Hawaii Seismic Imaging of Transition Zone Discontinuities Suggests Hot (2012) (0)
- Direct visualization of platelet integrins using anti-transmembrane domain peptides containing a blue fluorescent amino acid (2019) (0)
- NOE-based model of the influenza A virus M2 (19-49) bound to drug 11 (2014) (0)
- Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion. (2021) (0)
- De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-2 (2019) (0)
- ε 4 POTENTIATES THE RELATIONSHIP BETWEEN AMYLOID- b AND TAU PATHOLOGIES IN A DOSE- DEPENDENT MANNER (2018) (0)
- Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332 (2013) (0)
- MPSA abstracts (1994) (0)
- The Development of Small Molecule Inhibitors of Collagen Binding to the Integrin α2β1 as Antithrombotic Drugs. (2005) (0)
- The quinol oxidizing and charge separating structures of the ubiquinol cytochrome c oxidoreductase (1993) (0)
- Crystal structure of an antiparallel octameric transmembrane coiled coil K2-CCTM-VbIc (2021) (0)
- Theoretical and experimental studies of complex peptide-membrane systems: general discussion. (2021) (0)
- AGED ALZHEIMER’S DISEASE BRAINS EXHIBIT NUMEROUS Aβ BUT ONLY FEW TAU PRIONS (2018) (0)
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