William French Anderson

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#5180

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#7916

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#1392

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#2698

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#3728

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#614

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William French Anderson

Biology

#5769

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#8329

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#1939

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#613

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#696

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#223

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Molecular Biology

#751

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#768

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#175

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Why Is William French Anderson Influential?

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According to Wikipedia, William French Anderson is an American physician, geneticist and molecular biologist. He is known as the "father of gene therapy". He graduated from Harvard College in 1958, Trinity College, Cambridge University in 1960, and from Harvard Medical School in 1963. In 1990 he was the first person to succeed in carrying out gene therapy by treating a 4-year-old girl suffering from severe combined immunodeficiency . In 2006, he was convicted of sexual abuse of a minor and in 2007 was sentenced to 14 years in prison. He was paroled on May 17, 2018, for good behavior.

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William French Anderson's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cardiovascular Risk Associated With Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention (2005) (2002)
T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years (1995) (1412)
Celecoxib for the prevention of sporadic colorectal adenomas. (2006) (1030)
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation (1993) (971)
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. (1986) (535)
Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. (1994) (508)
A nanoliter-scale nucleic acid processor with parallel architecture (2004) (456)
Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients (1993) (435)
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. (1993) (417)
Improved methods of retroviral vector transduction and production for gene therapy. (1994) (401)
Microfluidic single-cell mRNA isolation and analysis. (2006) (342)
Seeding of intravascular stents with genetically engineered endothelial cells. (1989) (336)
Effect of internal viral sequences on the utility of retroviral vectors (1987) (325)
Continuous subcutaenous administration of deferoxamine in patients with iron overload. (1977) (290)
Scaling properties of a low-actuation pressure microfluidic valve (2004) (279)
Residues that mediate DNA binding of autoimmune antibodies. (1993) (275)
Site-directed neovessel formation in vivo. (1988) (270)
Gene expression in mice after high efficiency retroviral-mediated gene transfer. (1985) (250)
Recent trends in breast cancer among younger women in the United States. (2008) (249)
Prospects for human gene therapy. (1984) (225)
Localization of the human α-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay (1977) (219)
Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy. (1992) (217)
Safety issues related to retroviral-mediated gene transfer in humans. (1991) (211)
pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: implications for the role of the R peptide and p12E TM in viral entry (1994) (205)
The regulation of initiation of mammalian protein synthesis. (1981) (194)
Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. (1995) (192)
A mouse model for β-thalassemia (1983) (183)
Parallel picoliter rt-PCR assays using microfluidics. (2006) (182)
Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. (1987) (166)
Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. (1990) (160)
Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. (1990) (147)
Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy. (1989) (146)
Lymphocytes as cellular vehicles for gene therapy in mouse and man. (1991) (136)
High-level recombinant gene expression in rabbit endothelial cells transduced by retroviral vectors. (1989) (131)
Lymphocyte gene therapy. (1991) (130)
Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. (1980) (129)
Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent (1989) (128)
In utero gene therapy: transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses. (1998) (125)
Prospects for in utero human gene therapy. (1999) (124)
Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo. (1989) (124)
The effects of ultraviolet light on the biological and physical chemical properties of deoxyribonucleic acids. (1961) (123)
Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans. (1993) (121)
Sounding boards. Gene therapy in human beings: when is it ethical to begin? (1980) (120)
Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences. (1994) (120)
Breast cancer heterogeneity: a mixture of at least two main types? (2006) (116)
Cell-free hemoglobin synthesis. II. Characteristics of the transfer ribonucleic acid-dependent assay system. (1970) (112)
Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. (1995) (107)
Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein (1997) (101)
Determination of the binding affinity of an anti-CD34 single-chain antibody using a novel, flow cytometry based assay. (1997) (96)
Applications of the polymerase chain reaction in retroviral-mediated gene transfer and the analysis of gene-marked human TIL cells. (1990) (95)
Identification of a subdomain in the Moloney murine leukemia virus envelope protein involved in receptor binding (1996) (95)
Isolation and partial characterization of reticulocyte factors M1 and M2. (1970) (95)
Human gene therapy: why draw a line? (1989) (94)
Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells. (1998) (90)
Treatment of Severe Combined Immunodeficiency Disease (SCID) due to Adenosine Deaminase Deficiency with CD34+ Selected Autologous Peripheral Blood Cells Transduced with a Human ADA Gene (Amendment). National Institutes of Health (1993) (90)
Murine hematopoietic stem cell characterization and its regulation in BM transplantation. (2000) (89)
Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteins (1993) (89)
Purification and physical properties of homogeneous initiation factor MP from rabbit reticulocytes. (1975) (88)
Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells. (2005) (88)
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. (1990) (86)
New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma (1998) (85)
A uniquely stable replication-competent retrovirus vector achieves efficient gene delivery in vitro and in solid tumors. (2001) (84)
Eukaryotic initiation complex formation. Evidence for two distinct pathways. (1975) (83)
Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice. (1998) (82)
Identification of the block in targeted retroviral-mediated gene transfer. (1999) (81)
A mouse model for beta-thalassemia. (1983) (81)
Microfluidic vias enable nested bioarrays and autoregulatory devices in Newtonian fluids (2006) (80)
Cytoplasmic Tail of Moloney Murine Leukemia Virus Envelope Protein Influences the Conformation of the Extracellular Domain: Implications for Mechanism of Action of the R Peptide (2003) (78)
No retroviremia or pathology in long-term follow-up of monkeys exposed to a murine amphotropic retrovirus. (1991) (78)
Uncoupled expression of Moloney murine leukemia virus envelope polypeptides SU and TM: a functional analysis of the role of TM domains in viral entry (1994) (78)
Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis (1992) (77)
Structural and functional homology of parvovirus and papovavirus polypeptides. (1987) (75)
International symposium on protein synthesis Summary of Fogarty Center‐NIH Workshop held in Bethesda, Maryland on 18–20 October, 1976 (1977) (74)
Cell-free transcription of mammalian chromatin: transcription of globin messenger RNA sequences from bone-marrow chromatin with mammalian RNA polymerase. (1974) (73)
Induction of stable prenatal tolerance to beta-galactosidase by in utero gene transfer into preimmune sheep fetuses. (2001) (72)
Infectious Entry by Amphotropic as well as Ecotropic Murine Leukemia Viruses Occurs through an Endocytic Pathway (2001) (71)
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir. (1996) (71)
Determination of Infectious Retrovirus Concentration from Colony-Forming Assay with Quantitative Analysis (2003) (70)
Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes. (1971) (69)
Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation. (1975) (69)
In utero gene transfer and expression: a sheep transplantation model. (1989) (69)
EVALUATION OF CARDIAC FUNCTION IN PATIENTS WITH THALASSEMIA MAJOR (1980) (68)
Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids (1979) (68)
Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. (1998) (68)
The Development of Gene Therapy for the Treatment of Cancer (1993) (68)
Analysis of retroviral packaging lines for generation of replication-competent virus. (1990) (67)
Binding of MET-TRNAf and GTP to homogeneous initiation factor MP. (1975) (67)
Molecular engineering of matrix-targeted retroviral vectors incorporating a surveillance function inherent in von Willebrand factor. (2000) (67)
Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics (2010) (67)
Retroviral-mediated gene transfer. (1990) (67)
Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer. (1991) (66)
Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation. (2002) (64)
Purification and properties of bacteriophage T4-induced RNA ligase. (1976) (64)
Characterization of the Proline-Rich Region of Murine Leukemia Virus Envelope Protein (1998) (64)
Gene therapy using retroviral vectors. (1994) (63)
Structure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies. (1994) (63)
Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice. (2001) (62)
Binding kinetics of ecotropic (Moloney) murine leukemia retrovirus with NIH 3T3 cells (1995) (62)
Purification and characterization of homogeneous protein synthesis initiation factor M1 from rabbit reticulocytes. (1975) (62)
Downregulation of cyclin G1 expression by retrovirus-mediated antisense gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation. (1997) (60)
Antibody-mediated targeting of replication-competent retroviral vectors. (2003) (60)
Targeting retroviral vectors to vascular lesions by genetic engineering of the MoMLV gp70 envelope protein. (1997) (60)
Targeting retroviral vectors to CD34-expressing cells: binding to CD34 does not catalyze virus-cell fusion. (1999) (59)
Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector. (1987) (59)
Sequences determining the pH dependence of viral entry are distinct from the host range-determining region of the murine ecotropic and amphotropic retrovirus envelope proteins (1993) (58)
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma. (1999) (58)
Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system (1996) (56)
In utero transfer and expression of exogenous genes in sheep. (2000) (56)
High-throughput multi-antigen microfluidic fluorescence immunoassays. (2006) (55)
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. (1994) (53)
The analytical approach to polydimethylsiloxane microfluidic technology and its biological applications. (2006) (53)
Retroviral vector-mediated transfer of an antisense cyclin G1 construct inhibits osteosarcoma tumor growth in nude mice. (1997) (53)
The molecular mechanism of hemoglobin synthesis and its regulation in the reticulocyte. (1978) (53)
Identification of regions in the Moloney murine leukemia virus SU protein that tolerate the insertion of an integrin-binding peptide. (2000) (53)
[12] Initiation of globin synthesis: Assays (1974) (52)
Infection of human cells with murine amphotropic replication-competent retroviruses. (1993) (51)
Modulation of Activity of Moloney Murine Leukemia Virus Preintegration Complexes by Host Factors In Vitro (1998) (51)
Prospects for human gene therapy. (1984) (51)
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy? (1995) (51)
Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector. (1996) (51)
Receptor-Mediated Moloney Murine Leukemia Virus Entry Can Occur Independently of the Clathrin-Coated-Pit-Mediated Endocytic Pathway (1999) (50)
Isolation of protein synthesis initiation factors from rabbit liver. (1973) (50)
In vivo expression and survival of gene-modified T lymphocytes in rhesus monkeys. (1990) (50)
Identification of envelope protein residues required for the expanded host range of 10A1 murine leukemia virus (1997) (49)
Enhancement of the fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer. (1991) (48)
Extinction of hemoglobin inducibility in Friend erythroleukemia cells by fusion with cytoplasm of enucleated mouse neuroblastoma or fibroblast cells. (1977) (48)
Human gene therapy: scientific and ethical considerations. (1985) (48)
Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes. (1975) (47)
tRNA-dependent translational control of in vitro hemoglobin synthesis. (1969) (46)
Functional Domains in the Retroviral Transmembrane Protein (1998) (46)
Retroviral vectors expressing soluble CD4: a potential gene therapy for AIDS. (1990) (46)
Recent advances in retrovirus vector-mediated gene therapy: teaching an old vector new tricks. (2001) (46)
Mutational Analysis of the Fusion Peptide of Moloney Murine Leukemia Virus Transmembrane Protein p15E (1998) (45)
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. (1981) (44)
Translation of exogenous messenger RNA for hemoglobin on reticulocyte and liver ribosomes. (1971) (44)
Expression of a foreign gene in cats reconstituted with retroviral vector infected autologous bone marrow. (1991) (44)
Gene Marking and Autologous Bone Marrow Transplantation a (1994) (44)
The Best of Times, the Worst of Times (2000) (44)
Functional interactions between monomers of the retroviral envelope protein complex (1997) (44)
Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein. (2001) (44)
Experimentally validated quantitative linear model for the device physics of elastomeric microfluidic valves. (2007) (43)
Hemoglobin synthesis in somatic cell hybrids: globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts. (1975) (43)
Separation of two factors, M1 and M2, required for poly U dependent polypeptide synthesis by rabbit reticulocyte ribosomes at low magnesium ion concentration. (1970) (43)
Incorporation of Tumor Vasculature Targeting Motifs into Moloney Murine Leukemia Virus Env Escort Proteins Enhances Retrovirus Binding and Transduction of Human Endothelial Cells (2000) (43)
Retroviral vector-mediated transfer of the bacterial neomycin resistance gene into fetal and adult sheep and human hematopoietic progenitors in vitro. (1990) (43)
Epigenetic activation of phenylalanine hydroxylase in mouse erythroleukemia cells by the cytoplast of rat hepatoma cells. (1979) (43)
Capture and expansion of bone marrow-derived mesenchymal progenitor cells with a transforming growth factor-beta1-von Willebrand's factor fusion protein for retrovirus-mediated delivery of coagulation factor IX. (1997) (43)
Gene therapy scores against cancer (2000) (42)
Hemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia. (1973) (42)
Purification and properties of rabbit reticulocyte protein synthesis elongation factor 2. (1975) (41)
Gene expression in implanted rat hepatocytes following retroviral-mediated gene transfer (1989) (41)
Retroviral gene transfer in autologous bone marrow transplantation for adult acute leukemia. (1996) (40)
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. (1998) (39)
Extinction of globin gene expression in human fibroblast × mouse erythroleukemia cell hybrids (1976) (39)
Germ-Line Gene Therapy: A New Stage of Debate (1992) (39)
Retroviral vector-mediated gene transfer into keratocytes: in vitro effects of polybrene and protamine sulfate (1998) (39)
Hemoglobin McKees Rocks (alpha2beta2145Tyr leads to Term). A human "nonsense" mutation leading to a shortened beta-chain. (1976) (39)
Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene. (1998) (38)
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. (1984) (37)
Establishment and characterization of adenosine deaminase-deficient human T cell lines. (1989) (37)
A prospective study of adjuvant CMF in males with node positive breast cancer: 20-year follow-up (2007) (37)
Gene transfer into hematopoietic progenitor cells from normal and cyclic hematopoietic dogs using retroviral vectors. (1988) (37)
The β-globin gene is on the short arm of human chromosome 11 (1980) (36)
Retroviral gene therapy vectors for prevention of excimer laser-induced corneal haze. (2002) (36)
Thalassemia Major: Molecular and Clinical Aspects (1979) (36)
Hemoglobin switching in sheep and goats: change in functional globin messenger RNA in reticulocytes and bone marrow cells. (1972) (35)
Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34+ selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195, January 10, 1992. (1993) (35)
Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy. (1996) (34)
Three mouse models of human thalassemia. (1981) (34)
Retroviral vector-mediated gene transfer into keratocytes in vitro and in vivo. (1998) (34)
Further evaluation of soluble CD4 as an anti-HIV type 1 gene therapy: demonstration of protection of primary human peripheral blood lymphocytes from infection by HIV type 1. (1994) (33)
Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. (1980) (33)
[44] Mouse erythroleukemia cells (1979) (33)
Hemoglobin synthesis in somatic cell hybrids: coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells. (1975) (33)
Role of Variable Regions A and B in Receptor Binding Domain of Amphotropic Murine Leukemia Virus Envelope Protein (1998) (32)
A Mouse Model for b-Thalassemia (1982) (32)
High efficiency in vitro gene transfer into vascular tissues using a pseudotyped retroviral vector without pseudotransduction (1999) (31)
Initiation of globin synthesis. Preparation and use of reticulocyte ribosomes retaining initiation region messenger ribonucleic acid fragments. (1972) (30)
Inhibition of rabbit keratocyte and human fetal lens epithelial cell proliferation by retrovirus-mediated transfer of antisense cyclin G1 and antisense MAT1 constructs. (2000) (30)
Soluble factor(s) from bone marrow cells can rescue lethally irradiated mice by protecting endogenous hematopoietic stem cells. (2005) (29)
Downregulation of NPM-ALK by siRNA Causes Anaplastic Large Cell Lymphoma Cell Growth Inhibition and Augments the Anti Cancer Effects of Chemotherapy In Vitro (2007) (29)
[58] Preparation of globin messenger RNA (1974) (28)
Increased efficiency of retroviral-mediated gene transfer and expression in primate bone marrow progenitors after 5-fluorouracil- induced hematopoietic suppression and recovery (1991) (28)
Retroviral vectors for introduction of genes into mammalian cells. (1988) (28)
Differential activation of the mouse beta-globin promoter by enhancers (1983) (28)
Internally calibrated quantification of protein analytes in human serum by fluorescence immunoassays in disposable elastomeric microfluidic devices (2008) (27)
Mouse alpha-globin genes and alpha-globin-like pseudogenes are not syntenic. (1981) (26)
Cell-free transcription of mammalian chromatin. Quantitative measurement of newly synthesized globin messenger RNA sequences. (1975) (26)
Polypeptide chain initiation in eukaryotes: initiation factor requirements for translation of natural messengers. (1976) (25)
Translation of rabbit haemoglobin messenger RNA by thalassaemic and non-thalassaemic ribosomes. (1971) (25)
Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors. (2001) (24)
Retroviral-mediated gene transfer of bone marrow cells during autologous bone marrow transplantation for acute leukemia. (1992) (24)
Hemoglobin switching in sheep and goats. V. Effect of erythropoietin concentration on in vitro erythroid colony growth and globin synthesis (1975) (24)
Importance of full size complementary DNA in nucleic acid hybridization. (1976) (24)
Evaluation of desferrioxamine and ascorbic acid for the treatment of chronic iron overload. (1976) (23)
A conditional self-inactivating retrovirus vector that uses a tetracycline-responsive expression system (1997) (22)
Initiation of globin synthesis (1972) (22)
Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control. (1986) (22)
Prospects for gene therapy for immunodeficiency diseases. (1988) (22)
Gene transfer into primates and prospects for gene therapy in humans. (1989) (22)
Lesion-targeted injectable vectors for vascular restenosis. (2001) (21)
The amphotropic and ecotropic murine leukemia virus envelope TM subunits are equivalent mediators of direct membrane fusion: implications for the role of the ecotropic envelope and receptor in syncytium formation and viral entry (1995) (21)
Cell-free hemoglobin synthesis in beta-thalassemia. (1970) (20)
Increased efficiency of gene transfer with retroviral vectors in neonatal hematopoietic progenitor cells. (1990) (20)
Separation of reticulocyte initiation factor M 2 activity into two components. (1972) (20)
Human gene therapy. (1998) (20)
Development of a Clinical Protocol for Hepatic Gene Transfer: Lessons Learned in Preclinical Studies (1993) (19)
Initial dipeptide formation in hemoglobin biosynthesis. (1971) (19)
Neonatal gene therapy. transfer and expression of exogenous genes in neonatal sheep following direct injection of retroviral vectors into the bone marrow space. (2000) (19)
Initiation of protein synthesis in prokaryotic and eukaryotic systems Summary of EMBO workshop held in Noordwijkerhout, The Netherlands on 17–19 April 1974 (1974) (19)
[59] tRNA-dependent cell-free hemoglobin synthesis (1971) (19)
Retroviral vector-mediated in vivo expression of low-density-lipoprotein receptors in the Watanabe heritable hyperlipidemic rabbit (1991) (18)
Puromycin-peptide bond formation with reticulocyte initiation factors M1 and M2. (1971) (18)
Comparison of fMet-tRNAf and Met-tRNAf from Escherichia coli and rabbit liver in initiation of hemoglobin synthesis. (1975) (18)
Hemogloblin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures. (1973) (18)
Erythropoietin‐independent erythroid colony formation in patients with erythroleukaemia (M6) and related disorders (1982) (18)
Involvement of Niemann‐Pick Type C2 Protein in Hematopoiesis Regulation (2006) (17)
Mechanism of action of ribonucleic acid-directed deoxyribonucleic acid polymerase. I. Transcription of globin messenger ribonucleic acid. (1974) (17)
Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer. (1991) (17)
Gene therapy. The best of times, the worst of times. (2000) (17)
Mouse erythroleukemia cells. (1979) (17)
Polypeptide chain initiation in eukaryotes: mechanism of formation of initiation complex. (1976) (17)
Gene transfer and expression in nonhuman primates using retroviral vectors. (1986) (17)
Deletions in the alpha-globin gene complex in alpha-thalassemic mice. (1981) (17)
Promoter dependence of enhancer activity (1984) (17)
Fate and structure of DNA microinjected into mouse TK-L cells. (1984) (16)
Requirement for GTP in the initiation process on reticulocyte ribosomes and ribosomal subunits. (1971) (16)
Transduction of long-term-engrafting human hematopoietic stem cells by retroviral vectors. (2002) (16)
TNF/TIL Human Gene Therapy Clinical Protocol: Original Protocol, April 23, 1990 (1990) (16)
Retrovirus-mediated gene transfer targeted to retinal photocoagulation sites (1998) (15)
A ribosome dissociation factor from rabbit reticulocytes distinct from initiation factor M3. (1973) (15)
Electrical microfluidic pressure gauge for elastomer microelectromechanical systems. (2007) (15)
Transcription of single base oligonucleotides by ribonucleic acid- directed deoxyribonucleic acid polymerase (1976) (15)
Retrovirus-mediated transfer of the suicide gene into retinal pigment epithelial cells in vitro. (1997) (14)
Attempts at Gene Therapy in β‐Thalassemic Mice (1985) (14)
Correlation of gene expression and transformation frequency with the presence of an enhancing sequence in the transforming DNA (1984) (14)
Gene therapy in a murine model for clinical application to multiple sclerosis (2004) (14)
Genetic engineering of animals. (1986) (14)
Hemoglobin switching in sheep and goats. 3. Cell-free initiation of sheep globin synthesis. (1974) (14)
Molecular cloning and nucleotide sequence of cDNA encoding a functional murine low-density-lipoprotein receptor (1992) (13)
Prospects for Human Gene Therapy in the Born and Unborn Patient (1986) (13)
A 66-base pair insert bridges the deletion responsible for a mouse model of beta-thalassemia. (1986) (13)
Recombinant gene expression in human umbilical vein endothelial cells transduced by retroviral vectors. (1990) (13)
Human globin gene expression in hybrid 2S MEL × human fibroblast cells (1984) (13)
Preparation of rabbit reticulocyte initiation factor IF-M3. (1974) (13)
Initiation of hemoglobin synthesis: comparison of model reactions that use artificial templates with those using natural messenger RNA. (1972) (12)
Quantitation of MoMuLV envelope protein on the cell surface. (1998) (12)
Membrane destabilization assay based on potassium release from liposomes. (1999) (12)
Human gene therapy: scientific and ethical considerations. (1985) (12)
Clinical protocol. Tumor site specific phase I evaluation of safety and efficacy of hepatic arterial infusion of a matrix-targeted retroviral vector bearing a dominant negative cyclin G1 construct as intervention for colorectal carcinoma metastatic to liver. (2002) (12)
Isolation of an active transcription initiation complex from HeLa cell-free extract. (1984) (12)
Hemoglobin Messenger RNA from Human Bone Marrow (1973) (11)
Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes. (1998) (11)
Transfer of human and murine globin-gene sequences into transgenic mice. (1985) (11)
In vitro infection of human bone marrow by feline leukemia viruses. (1993) (11)
High-Dose Chemotherapy and Autologous Bone Marrow Plus Peripheral Blood Stem Cell Transplantation for Patients with Lymphoma or Metastatic Breast Cancer: Use of Marker Genes to Investigate Hematopoietic Reconstitution in Adults. University of Southern California, Norris Cancer Center, Los Angeles, C (1996) (11)
alpha-and beta-Globin complementary deoxyribonucleic acids of human and rabbit. Specificity of hybridization. (1975) (11)
HEMOGLOBIN SWITCHING IN SHEEP AND GOATS: ASPECTS OF THE MOLECULAR MECHANISM (1974) (10)
Preparation of protein synthesis initiation factors IF-M1, IF-M2A, and IF-M2B from rabbit reticulocytes. (1974) (10)
Mouse a-globin genes and a-globin-like pseudogenes are not syntenic* (10)
Membrane-proximal cytoplasmic domain of Moloney murine leukemia virus envelope tail facilitates fusion. (2008) (10)
Complementation of a Binding-Defective Retrovirus by a Host Cell Receptor Mutant (2004) (10)
Homologous globin cell-free transcription system with comparison of heterologous factors (1984) (9)
Isolation of stable preinitiation, initiation, and elongation complexes from RNA polymerase II-directed transcription. (1985) (9)
Drug Delivery by Genetically Engineered Cell Implants (1991) (9)
Human gene therapy. (1992) (8)
Phase I/II evaluation of safety and efficacy of a matrix-targeted retroviral vector bearing a dominant negative cyclin G1 construct (Md-dnG1) as adjunctive intervention for superficial corneal opacity/corneal scarring. (2003) (8)
Induction of mouse erythroleukemia cells by microinjection of inducing compound. (1981) (8)
Genetic Engineering of Targeted Retroviral Vectors (2003) (8)
Diagnostic use of CFU-E formation from peripheral blood in polycythemia vera. (1983) (8)
Ability of retroviral transduction to modify the angiogenic characteristics of RPE cells (1998) (8)
Deletions in the a-globin gene complex in a-thalassemic mice ( Southern blotting technique / mouse genetics / hemoglobin / mutation ) (7)
Gene therapy for genetic diseases. (1989) (7)
Human gene therapy protocols: RAC review. (1995) (7)
The beta-globin gene is on the short arm of human chromosome 11. (1980) (7)
Regulation of murine hematopoietic stem cell proliferation in vivo (2000) (7)
Gene expression using retroviral vectors. (1990) (7)
Increased efficiency of retroviral-mediated gene transfer and expression in primate bone marrow progenitors after 5-fluorouracil-induced hematopoietic suppression and recovery. (1991) (7)
Paper electrophoresis and chromatography of oligopeptides with N-terminal methionine. (1973) (6)
Lack of site specific recombination of exogenous DNA in mouse L cells. (1983) (6)
Preparation of protein synthesis initiation factors from rabbit liver. (1974) (6)
Chimeric envelope glycoproteins constructed between amphotropic and xenotropic murine leukemia retroviruses (1995) (6)
Separation of human from mouse and monkey adenosine deaminase by ion-exchange chromatography following retroviral-mediated gene transfer. (1987) (6)
A genetic therapy for familial hypercholesterolemia. (1990) (6)
Regulation of human globin gene expression in mouse erythroleukemia × human fibroblast hybrid cells (1982) (5)
Sequences present in a small region of the AKV virus envelope gene determine the efficiency with which pseudotyped spleen focus-forming virus infects erythroid target cells. (1992) (5)
Infection of human hematopoietic progenitor cells using a retroviral vector with a xenotropic pseudotype. (1988) (5)
Retroviral-mediated gene transfer into hemopoietic cells. (1988) (5)
CELL‐FREE SYNTHESIS OF GLOBIN CHAINS:AN OVERVIEW (1974) (5)
CELL‐FREE TRANSCRIPTION OF HUMAN BONE MARROW CHROMATIN (1974) (5)
Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein. (2008) (5)
Mixed myeloid—lymphoid colonies in a patient with polycythemia vera (1982) (5)
Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells (1991) (5)
Initiation of globin synthesis: assays. (1974) (4)
The expression of integrated plasmid DNA depends on copy number. (1987) (4)
The purification and characterization of subunits α, β, and γ from the rabbit reticulocyte eukaryotic initiation factor 2 (1987) (4)
A HUMAN "NONSENSE" MUTATION LEADING TO A SHORTENED ,-CHAIN (1976) (4)
Morphological and molecular classification of human cancer (2017) (4)
Activation and inactivation of genes determining hemoglobin types (1975) (4)
Cellular and molecular studies on globin gene expression. (1978) (4)
Development of systemic immunologic responses against hepatic metastases during gene therapy for peritoneal carcinomatosis with retroviral HS-tk and ganciclovir (1997) (3)
In reply: murine retroviral vectors and human gene therapy. (1985) (3)
Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. (1999) (3)
Quantitative synthesis of full-length globin genes: dependence on template. (1978) (3)
Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo (1990) (3)
Fibrosarcoma Protein 78 Promoter in Suicide Gene Therapy of Murine Use of the Glucose Starvation-inducible Glucose-regulated Updated (1999) (3)
Human gene therapy. (1992) (3)
Translational control of in vitro hemoglobin synthesis. (1969) (3)
The influence of patient-related factors on ex vivo retroviral-mediated gene transfer into mobilized peripheral blood myeloid progenitors. (1998) (3)
Non-Hodgkin lymphoma in early life. (2012) (3)
Retroviral Vector‐mediated Gene Transfer and Expression in Nonhuman Primates Following Autologous Bone Marrow Transplantation a (1987) (2)
Differential Activation oftheMouse,-Globin Promoter by Enhancers (1983) (2)
Quantitation of retroviral-mediated transfer using luciferase in living and lysed cells. (2001) (2)
Targeted siRNA inhibition of NPM-ALK in anaplastic large cell lymphoma causes disease specific growth inhibition which augments chemotherapeutic agents (2005) (2)
Development of Retroviral Vectors that Target Hematopoietic Stem Cells (2000) (2)
High-dose chemotherapy and autologous bone marrow plus peripheral blood stem cell transplantation for patients with lymphoma or metastatic breast cancer: use of marker genes to investigate hematopoietic reconstitution in adults. (1996) (2)
REGULATION OF GLOBIN GENE EXPRESSION AT THE MOLECULAR LEVEL (1980) (2)
Cycling of RNA-directed DNA polymerase on natural and synthetic RNA templates (1976) (2)
PCR and other test systems in human gene therapy. (1992) (2)
Attempts at gene therapy in beta-thalassemic mice. (1985) (2)
Methionine transfer RNAF: the initiator transfer RNA for hemoglobin biosynthesis. (1971) (2)
A cure that may cost us ourselves. Society: one of the pioneers of human genetic engineering predicts that within 30 years, there will be a gene-based therapy for most diseases. But he fears the profound dangers of his own work. (2000) (2)
ISOLATION AND TRANSLATION OF MESSENGER RNA FROM β‐THALASSEMIA RED CELLS (1974) (2)
Mouse models of human thalassemia. (1982) (2)
Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids. (1979) (2)
Bringing Gene Therapy to the Clinic (2000) (2)
Mass spectrometry of murine leukemia virus core proteins. (2010) (2)
Corrections: Heparain-Binding Growth Factor 1 Induces the Formation of Organoid Neovascular Structures In vivo (1990) (1)
Preparation of globin messenger RNA. (1974) (1)
Gene Transfer in Canine and Feline Hematopoietic Progenitor Cells with Retroviral Vectors (1989) (1)
Globin gene expression in somatic cell hybrids. (1983) (1)
Gene therapy researchers. (1984) (1)
Transcription of chromatin with prokaryotic and eukaryotic polymerases. (1978) (1)
Initiation of globin synthesis in beta-thalassemia. (1973) (1)
δ-Aminolevulinate dehydratase: Induced expression and regional assignment of the human gene to chromosome 9q13»qter (2004) (1)
Gene transfer into animals by retroviral vectors. (1986) (1)
FROM THE GENETIC CODE TO BETA THALASSEMIA (1984) (1)
A new technique for mapping the human hemoglobin genes. (1976) (1)
250. Cell-free transcription of mammalian globin genes (1974) (1)
The purification and characterization of subunits alpha, beta, and gamma from the rabbit reticulocyte eukaryotic initiation factor 2. (1987) (1)
Risks inherent in fetal gene therapy (1999) (1)
MSJAMA: bringing gene therapy to the clinic. (2000) (1)
Genetic engineering in mammalian cells. (1981) (1)
Microfluidic Systems for Studying Cell Migration Regulation (2006) (1)
Modified viral envelope polypeptide (1997) (0)
Correlation ofGeneExpression andTransformation Frequency with thePresence ofan Enhancing Sequence intheTransforming DNA (1984) (0)
Homologous GlobinCell-Free Transcription Systemwith Comparison ofHeterologous Factors (1984) (0)
Gene Therapy for Immunodeficiency and Cancer (1993) (0)
Regulation of Globin Gene Expression (2008) (0)
Translation ofExogenous Messenger RNA forHemoglobin onReticulocyte andLiver Ribosomes (1971) (0)
770 REGIONAL ASSIGNMENT OF HUMAN PBG-DEAMINASE (PBGD) AND ESTERASE A4 (ESA4) TO 11q23 11qter (1981) (0)
Effect of erythropoietin on hemoglobin synthesis. (1977) (0)
Hematopoietic Stem Cells: Identification, Characterization, and Assays (2003) (0)
leukemia retrovirus with NIH 3 T 3 cells . Binding kinetics of ecotropic ( Moloney ) murine (1995) (0)
Three mouse models of human thalassemia ( DNA-RNA hybridization / restriction endonuclease mapping / globin synthesis ) (0)
To proteins to extracellular matrix constituents tethering modified (1998) (0)
Separation ofReticulocyte Initiation Factor M2Activity intoTwoComponents (1972) (0)
Gene Therapy Clinical Trials for Adenosine Deaminase Deficiency/Severe Combined Immunodeficiency (2020) (0)
sensitive cells TGF beta 1 derived from bone marrow. (1997) (0)
retroviral vectors containing sites internal ribosome entry. (1992) (0)
PL-10 Gene therapy: Application to the treatment of hepatocellular carcinoma (1995) (0)
Isolation and translation of messenger RNA from beta-thalassemia red cells. (1974) (0)
DNA technology continues to improve (1989) (0)
The role of initiation factors in hemoglobin synthesis. (1972) (0)
ENZYMATIC SYNTHESIS OF RABBIT GLOBIN GENES: COMPARISON OF T4 DNA POLYMERASE AND RNA-DIRECTED DNA POLYMERASE (1977) (0)
GENE THERAPY (1996) (0)
Gene therapy. (1995) (0)
MurineLeukemia VirusBinding to Cells byImmunofluorescence Analysis (1992) (0)
Subject Index Vol. 16, 1976 (1976) (0)
Addressing pharmaceutical agents injured tissues. (1999) (0)
The synthesis of DNA complementary to rabbit globin mRNA by the enzyme (2003) (0)
Internal ribosome entry provide retroviral vectors contained (1992) (0)
Advances toward somatic cell gene therapy. (1991) (0)
Initial Dipeptide Formation in Hemoglobin Biosynthesis ( ribosomes / rabbit / initiation factors / elongation factor / endogenous messenger RNA ) (0)
The expression of cyclin g1 in tumors (1996) (0)
Human Gene Therapy: A New Beginning (1998) (0)
Effects of gene transfer into keratocytes on corneal wound healing after excimer laser keratectomy (1997) (0)
Purification and Characterization of Homogeneous Protein Synthesis Initiation Factor Ml from Rabbit Reticulocytes (1998) (0)
Gene Therapy: I. Strategies for Gene Therapy (1995) (0)
Regulation of Human Globin Gene Expression after Gene Transfer (1981) (0)
A Ribosome Dissociation Factor from Rabbit Reticulocytes Distinct from Initiation Factor M 3 ( elongation factors / protein synthesis / sucrose density gradients / protein purification ) (1999) (0)
Human Gene Therapy: The Initial Concepts (2020) (0)
A new technique for mapping the human hemoglobin genes. (1976) (0)
[Study of suicidal gene therapy and its vaccine effect]. (1997) (0)
Growth of erythroid colonies from mammalian bone marrow. (1974) (0)
IDENTIFICATION OF DEFECTIVE GLOBIN mRNA IN MEL × FIBROBLAST HYBRID CELLS (1982) (0)
Apparatus for preparing cDNA libraries from single cells (2017) (0)
Letter to the Editor: Assignments of 1H, 15N and 13C resonances of the proline-rich matrix protein of Moloney Murine Leukemia Virus (MA MoMuLV) (2003) (0)
Response: Re: Recent Trends in Breast Cancer Among Younger Women in the United States (2009) (0)
Proteines modifiees se fixant a des composants de matrice extracellulaires (1998) (0)
Targeted administration of artificial genes (2000) (0)
Gene therapy. (1981) (0)
The problem of nuclease activity in nucleic acid hybridization reactions. Theoretical considerations. (1977) (0)
24 Human Gene Therapy: Public Policy and Regulatory Issues (1999) (0)
INHIBITION OF RABBIT KERATOCYTE CELL PROLIFERATION BY RETROVIRUS-MEDIATED TRANSFER OF ANTISENSE CYCLIN G1 AND ANTISENSE MAT1 CONSTRUCTS TO PREVENT CORNEAL HAZE DEVELOPMENT AFTER PHOTOREFRACTIVE/PHOTOTHERAPEUTIC KERATECTOMY. (2000) (0)
EVALUATION OF RETROVIRAL MEDIATED GENE TRANSFER BY IN SITU HYBRIDIZATION (1987) (0)

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