Bil Clemons
American structural biologist
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Biology
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(Suggest an Edit or Addition)According to Wikipedia, William "Bil" Clemons, Jr. is an American structural biologist and Professor of Biochemistry at Caltech. He is best known for his work solving the atomic structure of the ribosome with dissertation advisor, Nobel Prize winner in Chemistry, Venki Ramakrishnan. He is also known for his work on the structure and function of proteins involved in membrane translocation and docking of proteins, including the membrane protein translocation channel SecY, chaperones involved in the targeting of tail-anchored membrane proteins in the Get pathway, and signal recognition proteins of the Twin-arginine translocation pathway. He was elected a member of the National Academy of Sciences in 2022.
Bil Clemons's Published Works
Published Works
- X-ray structure of a protein-conducting channel (2004) (1227)
- Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution (1999) (345)
- Crystal Structure of the Long-Chain Fatty Acid Transporter FadL (2004) (191)
- Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY (2005) (178)
- A large conformational change of the translocation ATPase SecA. (2004) (162)
- Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination. (2001) (133)
- Ribosome binding of a single copy of the SecY complex: implications for protein translocation. (2007) (111)
- Modeling the Effects of prl Mutations on the Escherichia coli SecY Complex (2005) (87)
- Model for eukaryotic tail-anchored protein binding based on the structure of Get3 (2009) (85)
- Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain (2014) (76)
- Structural characterization of the Get4/Get5 complex and its interaction with Get3 (2010) (74)
- The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. (2013) (73)
- Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (1999) (72)
- The complex process of GETting tail-anchored membrane proteins to the ER. (2012) (68)
- Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni. (2014) (67)
- A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex* (2011) (64)
- Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. (2012) (63)
- Structural insight into the protein translocation channel. (2004) (59)
- USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation (2014) (54)
- Conformational variability of the N-terminal helix in the structure of ribosomal protein S15. (1998) (52)
- Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4 (2014) (49)
- Precise timing of ATPase activation drives targeting of tail-anchored proteins (2013) (46)
- Tail‐anchor targeting by a Get3 tetramer: the structure of an archaeal homologue (2012) (38)
- Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni (2014) (27)
- Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex* (2012) (25)
- Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli. (2009) (20)
- Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35 (2017) (19)
- A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency. (2016) (17)
- Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores (2018) (14)
- Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting* (2015) (14)
- Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2 (2021) (13)
- Improving membrane protein expression by optimizing integration efficiency (2017) (12)
- A statistical model for improved membrane protein expression using sequence-derived features (2018) (11)
- Sequence‐based features that are determinant for tail‐anchored membrane protein sorting in eukaryotes (2021) (10)
- Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate. (2019) (9)
- Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes. (2015) (9)
- Complexity in targeting membrane proteins (2018) (8)
- The STI1‐domain is a flexible alpha‐helical fold with a hydrophobic groove (2021) (8)
- Structure of the small ribosomal subunit (2000) (5)
- A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides (2015) (5)
- Decoding sequence-level information to predict membrane protein expression (2017) (4)
- A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies (2019) (3)
- The client-binding domain of the cochaperone Sgt2 has a helical-hand structure that binds a short hydrophobic helix (2019) (3)
- Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays. (2019) (3)
- DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors. (2020) (3)
- Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3 (2022) (2)
- Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor. (2022) (2)
- Structures of Bacterial Ribosomal Proteins: High-Resolution Probes of the Architecture and Mechanism of the Ribosome (2000) (2)
- Structural biologists, let’s mind our colors (2020) (1)
- The structure of a protein conducting channel (2004) (1)
- Get 5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get 4 / Get 5 Complex * (2012) (1)
- Crystal structure of the bacterial fatty acid transporter FadL from Escherichia coli (2004) (1)
- Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis (2004) (0)
- Crystal structure of the Sgt2 TPR domain from Aspergillus fumigatus (2011) (0)
- A Link between Integral M embrane Protein Expression and Simulated Integration Efficiency Graphical (2016) (0)
- Crystal Structure of Twin Arginine Translocase Receptor- TatC (2013) (0)
- Predicting Membrane Protein Expression in Yeast from Sequence-Derived Features (2017) (0)
- 6.0 A Crystal structure of a Get3-Get4-Get5 intermediate complex from S.cerevisiae (2015) (0)
- Crystal Structure of Get3 from Methanocaldococcus jannaschii (2011) (0)
- Solution structure of the Get5 carboxyl domain from S. cerevisiae (2012) (0)
- Crystal structure of S. cerevisiae Get3 at 3.7 Angstrom resolution (2009) (0)
- Towards a Universal Characterization of the Membrane Protein Expression Landscape (2017) (0)
- Being Black in biophysics. (2023) (0)
- Sequence-level prediction and control of the production of a membrane protein (2016) (0)
- Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3 (2022) (0)
- Crystal Structure of Twin Arginine Translocase Receptor- TatC in DDM (2013) (0)
- Solution structure of the Sgt2 homodimerization domain (2012) (0)
- Solution structure of the Get5 carboxyl domain from A. fumigatus (2012) (0)
- Crystal structure of S. cerevisiae Get4 in complex with an N-terminal fragment of Get5 (2010) (0)
- Capturing the signal High-resolution structures provide new insights into how an RNA-protein complex recognizes the signal that targets membrane proteins to the endoplasmic reticulum before they aggregate. (2015) (0)
- Crystal structure of the SGTA homodimerization domain with a covalent modification of a single C38 (2012) (0)
- Crystal structure of an ATP-bound Get3-Get4-Get5 complex from S.cerevisiae (2014) (0)
- Structures of Get3d reveal a distinct architecture associated with the emergence of photosynthesis. (2023) (0)
- 2.8 A crystal structure of a Get3-Get4-Get5 intermediate complex from S.cerevisiae (2015) (0)
- Promiscuous Binding of Membrane Proteins on Flexible Co-Chaperones, Yeast Sgt2 and Human SGTA (2016) (0)
- Crystal structure of the Get5 carboxyl domain from S. cerevisiae (2012) (0)
- Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor (2022) (0)
- Crystal structure of Aspergillus fumigatus Get3 with bound ADP (2009) (0)
- Crystal structure of the SGTA homodimerization domain (2012) (0)
- Higher order assemblies in the GET membrane protein targeting pathway (2012) (0)
- Capturing the signal (2015) (0)
- A Machine Learning Approach to Heterologous Membrane Protein Overexpression (2016) (0)
- 1.8 angstrom crystal structure of the human Bag6-NLS & TRC35 complex (2017) (0)
- Statistical Models Robustly Predict Membrane Protein Expression in E. Coli (2017) (0)
- The structure of a tail‐anchor membrane protein‐binding complex reveals the regulation of Get3 by Get4 (950.4) (2014) (0)
- Crystal structure of the Get5 ubiquitin-like domain (2012) (0)
- Solution structure of the Get5 ubiquitin-like domain (2012) (0)
- Crystal Structure of Bag6-Ubl4A Dimerization Domain (2014) (0)
- Structural basis for phage single gene lysis protein mechanisms. (2023) (0)
- Structural investigations of the Get4/Get5/Sgt2 complex (2012) (0)
- The Structural and Biochemical Characterization of Members of the Mammalian TA Protein Sorting Complex (2012) (0)
- Author response: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation (2013) (0)
- The structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35 (2017) (0)
- The structure of the UDP-Glc/GlcNAc 4-epimerase from the human pathogen Campylobacter jejuni (2020) (0)
- Crystal structure of the SGTA homodimerization domain with covalent modifications to both C38 (2012) (0)
- PARTIAL MODEL FOR 30S RIBOSOMAL SUBUNIT (1999) (0)
- Solution structure of the complex between the Sgt2 homodimerization domain and the Get5 UBL domain (2012) (0)
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