William Jencks
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American biochemist
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William Jencks's Degrees
- PhD Chemistry California Institute of Technology
- Bachelors Chemistry University of California, Berkeley
Why Is William Jencks Influential?
(Suggest an Edit or Addition)According to Wikipedia, William Platt Jencks was an American biochemist. He was noted particularly for his work on enzymes, using concepts drawn from organic chemistry to understand their mechanisms. Career Jencks graduated from Harvard College in 1947 with a degree in English, and earned a Doctor of Medicine from Harvard University in 1951. He interned at the Peter Bent Brigham hospital. Jencks conducted his first postdoctoral research for two years with Fritz Lipmann at Harvard Medical School. Jencks was drafted into the Army Medical Corps and was assigned to the Army Medical Service Graduate School at Walter Reed Medical Center in Washington, DC. He worked with E. L. Durrum and served as the chair of the department of pharmacology. In 1956–1957, he did a second Public Health Service postdoc with R. B. Woodward of the Harvard University Department of Chemistry. In 1957, he moved to the new graduate program in biochemistry at Brandeis University. He became professor emeritus in 1996.
William Jencks's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Catalysis in chemistry and enzymology (1969) (2129)
- Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect. (1971) (818)
- A primer for the Bema Hapothle. An empirical approach to the characterization of changing transition-state structures (1985) (418)
- On the Mechanism of Schiff Base Formation and Hydrolysis (1962) (366)
- THE EFFECT OF COMPOUNDS OF THE UREA-GUANIDINIUM CLASS ON THE ACTIVITY COEFFICIENT OF ACETYLTETRAGLYCINE ETHYL ESTER AND RELATED COMPOUNDS. (1965) (354)
- General acid-base catalysis of complex reactions in water (1972) (349)
- Reactivity of Nucleophilic Reagents toward Esters (1960) (301)
- Studies on the Mechanism of Oxime and Semicarbazone Formation1 (1959) (296)
- THE EFFECT OF CONCENTRATED SALT SOLUTIONS ON THE ACTIVITY COEFFICIENT OF ACETYLTETRAGLYCINE ETHYL ESTER. (1965) (270)
- Nonlinear structure-reactivity correlations. The reactivity of nucleophilic reagents toward esters (1968) (269)
- When is an intermediate not an intermediate? Enforced mechanisms of general acid-base, catalyzed, carbocation, carbanion, and ligand exchange reaction (1980) (252)
- Ionization Constants of Acids and Bases (2010) (252)
- The Mechanism of Hydrolysis of Schiff Bases Derived from Aliphatic Amines (1963) (238)
- The mechanism of the aminolysis of acetate esters. (1974) (237)
- Ingold Lecture. How does a reaction choose its mechanism (1981) (206)
- Nonlinear structure-reactivity correlations. Acyl transfer between sulfur and oxygen nucleophiles (1977) (191)
- Ester aminolysis. Structure-reactivity relationships and the rate-determining step in the aminolysis of substituted diphenyl carbonates (1977) (170)
- The relationship of structure to the effectiveness of denaturing agents for proteins. (1963) (166)
- INTERACTIONS OF UREA AND OTHER POLAR COMPOUNDS IN WATER (1975) (161)
- Nucleophilic Catalysis of Semicarbazone Formation by Anilines (1962) (161)
- The Reactivity of Nucleophilic Reagents toward the p-Nitrophenyl Phosphate Dianion1 (1965) (160)
- The relationship of structure to the effectiveness of denaturing agents for deoxyribonucleic acid. (1963) (151)
- The mechanism of the condensation of formaldehyde with tetrahydrofolic acid. (1966) (147)
- IUPAC recommendations for the representation of reaction mechanisms (1989) (133)
- Mechanism and Catalysis of Reactions of Acyl Phosphates. II. Hydrolysis1 (1961) (132)
- Paper electrophoresis as a quantitative method: the staining of serum lipoproteins. (1955) (132)
- Equilibria for additions to the carbonyl group (1968) (131)
- Paper electrophoresis as a quantitative method; serum proteins. (1955) (130)
- Enforced general acid-base catalysis of complex reactions and its limitations (1976) (129)
- General base catalysis of ester hydrolysis (1961) (123)
- Lifetimes of oxocarbenium ions in aqueous solution from common ion inhibition of the solvolysis of α-azido ethers by added azide ion (1989) (120)
- Thiol addition to the carbonyl group. Equilibria and kinetics. (1966) (119)
- The utilization of binding energy in coupled vectorial processes. (2006) (116)
- Optical properties of astaxanthin solutions and aggregates. (1968) (115)
- General Base Catalysis of the Aminolysis of Phenyl Acetate1 (1960) (110)
- Energetics of the calcium-transporting ATPase. (1984) (109)
- Mechanism and Catalysis of Reactions of Acyl Phosphates. I. Nucleophilic Reactions1 (1961) (109)
- Acetylpyridinium ion intermediate in pyridine-catalyzed hydrolysis and acyl transfer reactions of acetic anhydride. Observation, kinetics, structure-reactivity correlations, and effects of concentrated salt solutions (1970) (108)
- The characterization of transition states by structure-reactivity coefficients (1977) (105)
- Formation and stability of ring-substituted 1-phenylethyl carbocations (1984) (105)
- Ester aminolysis. Partitioning of the tetrahedral addition intermediate, T.+-., and the relative leaving ability of nitrogen and oxygen (1977) (102)
- Imidazole catalysis. II. Acyl transfer and the reactions of acetyl imidazole with water and oxygen anions. (1959) (101)
- Acetyl-coenzyme A: arylamine N-acetyltransferase. Role of the acetyl-enzyme intermediate and the effects of substituents on the rate. (1971) (98)
- The dissociation constants of tetrahydrofolic acid. (1966) (96)
- Properties of the crustacyanins and the yellow lobster shell pigment. (1968) (96)
- Reactions of substituted 1-phenylethyl carbocations with alcohols and other nucleophilic reagents (1984) (96)
- Nonlinear Structure-Reactivity Correlations. The Imidazole-Catalyzed Hydrolysis of Esters (1964) (95)
- Equilibria for the reaction of amines with formaldehyde and protons in aqueous solution. A re-examination of the formol titration. (1966) (93)
- Solvolysis of D-glucopyranosyl derivatives in mixtures of ethanol and 2,2,2-trifluoroethanol (1980) (91)
- The Reaction of Hydroxylamine with Activated Acyl Groups. I. Formation of O-Acylhydroxylamine1 (1958) (91)
- Reactions of anionic nucleophiles with .alpha.-D-glucopyranosyl fluoride in aqueous solution through a concerted, ANDN (SN2) mechanism (1991) (90)
- Semicarbazone formation from pyridoxal, pyridoxal phosphate, and their Schiff bases. (1962) (89)
- Structure-reactivity correlations for reactions of substituted phenolate anions with acetate and formate esters (1993) (86)
- Thiazolium C(2)-proton exchange: structure-reactivity correlations and the pKa of thiamin C(2)-H revisited. (1988) (86)
- Alcohol-bicarbonate-water system. Structure-reactivity studies on the equilibriums for formation of alkyl monocarbonates and on the rates of their decomposition in aqueous alkali (1975) (86)
- The effect of substituents on the deacylation of benzoyl-chymotrypsins. (1962) (86)
- A study of serum lipoproteins in normal and atherosclerotic patients by paper electrophoretic techniques. (1956) (85)
- Evidence for two concurrent mechanisms and a kinetically significant proton transfer process in acid-catalyzed O-methyloxime formation (1974) (85)
- The effect of divalent metal ions on the rate and transition-state structure of phosphoryl-transfer reactions (1987) (85)
- Trapping of the oxocarbonium ion intermediate in the hydrolysis of acetophenone dimethyl ketals (1977) (84)
- Separation of polar and resonance substituent effects in the reactions of acetophenones with bisulfite and of benzyl halides with nucleophiles (1979) (84)
- Catalysis of the hydrolysis of phosphorylated pyridines by Mg(OH)+: a possible model for enzymatic phosphoryl transfer. (1990) (82)
- Requirements for general acid-base catalysis of complex reactions (1972) (82)
- General Acid Catalysis of Semicarbazone Formation (1962) (81)
- The Effect of Structure on Reactivity in Semicarbazone Formation1 (1960) (80)
- Mechanism of solvolysis of substituted benzoyl halides (1989) (80)
- Reactions of pyridines and primary amines with N-phosphorylated pyridines (1984) (79)
- Pig liver esterase. Reactions with alcohols, structure-reactivity correlations, and the acyl-enzyme intermediate. (1971) (79)
- Base Catalysis of Imidazole Catalysis of Ester Hydrolysis (1964) (79)
- Alkaline phosphatase is an almost perfect enzyme. (1994) (78)
- Imine-Forming Elimination Reactions. I. General Base Acid Catalysis and Influence of the Nitrogen Substituent on Rates and Equilibria for Carbinolamine Dehydration (1973) (78)
- Equilibria and Rates for Acetyl Transfer among Substituted Phenyl Acetates, Acetylimidazole, O-Acylhydroxamic Acids, and Thiol Esters (1964) (77)
- DEPOLYMERIZATION OF F-ACTIN BY CONCENTRATED SOLUTIONS OF SALTS AND DENATURING AGENTS. (1965) (74)
- Evidence that metaphosphate monoanion is not an intermediate in solvolysis reactions in aqueous solution (1989) (73)
- Mechanism of the Reaction of Imido Esters with Amines (1962) (72)
- The free energy of thiol ester hydrolysis. (1960) (72)
- A simple relationship between carbocation lifetime and reactivity-selectivity relationships for the solvolysis of ring-substituted 1-phenylethyl derivatives (1982) (71)
- Concerted bimolecular substitution reactions of 1-phenylethyl derivatives (1984) (70)
- Utilization of binding energy and coupling rules for active transport and other coupled vectorial processes. (1989) (70)
- Pig liver esterase. Physical properties. (1969) (69)
- Phosphoryl Transfer to Anionic Oxygen Nucleophiles. Nature of the Transition State and Electrostatic Repulsion (1989) (69)
- Reactions of cyanide with cobalamins (1979) (69)
- Mechanisms of general acid and base catalysis of the reactions of water and alcohols with formaldehyde (1978) (68)
- Hydrogen bonding between solutes in aqueous solution (1986) (68)
- Studies on the initial step of fatty acid activation. (1957) (68)
- Nonlinear Broensted correlations: The roles of resonance, solvation, and changing transition-state structure (1982) (66)
- Mechanism of reactions of N-(methoxymethyl)-N,N-dimethylanilinium ions with nucleophilic reagents (1980) (64)
- Equilibrium deuterium isotope effects on the ionization of thiol acids (1971) (63)
- Sequential dissociation of Ca2+ from the calcium adenosinetriphosphatase of sarcoplasmic reticulum and the calcium requirement for its phosphorylation by ATP. (1988) (62)
- Nucleophilic reactivity toward acetyl chloride in water (1984) (61)
- The mechanism of the aminolysis of methyl formate (1968) (61)
- Reactions of Nucleophilic Reagents with Phosphoramidate1 (1965) (61)
- The Reaction of Hydroxylamine with Activated Acyl Groups. II. Mechanism of the Reaction (1958) (60)
- Mechanism of cleavage of carbamate anions (1980) (60)
- General base catalysis, structure-reactivity interactions, and merging of mechanisms for elimination reactions of (2-arylethyl)quinuclidinium ions (1982) (59)
- General acid and general base catalysis of the methoxyaminolysis of 1-acetyl-1,2,4-triazole (1974) (57)
- Coenzyme A Transferase KINETICS AND EXCHANGE REACTIONS (1967) (57)
- Acid- and base-catalyzed decomposition of acetaldehyde hydrate and hemiacetals in aqueous solution (1987) (56)
- CHAPTER 6 – Studies on the Mechanism of Oxime and Semicarbazone Formation† (1968) (54)
- The clinical significance of the analysis of serum protein distribution by filter paper electrophoresis. (1956) (52)
- Imidazole catalysis. III. General base catalysis and the reactions of acetyl imidazole with thiols and amines. (1959) (52)
- Nucleophiles of high reactivity in phosphoryl transfer reactions: .alpha.-effect compounds and fluoride ion (1990) (51)
- Mechanism and Catalysis of Simple Carbonyl Group Reactions (2007) (50)
- Reactions of the sarcoplasmic reticulum calcium adenosinetriphosphatase with adenosine 5'-triphosphate and Ca2+ that are not satisfactorily described by an E1-E2 model. (1987) (49)
- Identification of an Enzyme-γ-Glutamyl Coenzyme A Intermediate from Coenzyme A Transferase (1969) (49)
- Decreasing reactivity with increasing nucleophile basicity. The effect of solvation on .beta.nuc for phosphoryl transfer to amines. (1986) (49)
- Reactivity and catalysis in reactions of the serine hydroxyl group and of O-acyl serines. (1961) (49)
- Paper electrophoresis as a quantitative method: measurement of alpha and beta lipoprotein cholesterol. (1955) (47)
- General Base Catalysis of the Aminolysis of Phenyl Acetate by Primary Alkylamines1 (1966) (47)
- Slow dissociation of ATP from the calcium ATPase. (1982) (47)
- Reactions of nucleophilic reagents with acylating agents of extreme reactivity and unreactivity. Correlation of .beta. values for attacking and leaving group variation (1970) (46)
- Intramolecular catalysis in the reactions of nucleophilic reagents with aspirin. (1968) (46)
- The mechanism of nitrone formation. A defense of anthropomorphic electrons. (1966) (45)
- Diffusion-controlled proton transfer in intramolecular thiol ester aminolysis and thiazoline hydrolysis (1969) (45)
- From chemistry to biochemistry to catalysis to movement. (1997) (44)
- Phosphorylation of the calcium adenosinetriphosphatase of sarcoplasmic reticulum: rate-limiting conformational change followed by rapid phosphoryl transfer. (1986) (44)
- THE DENATURATION OF CRUSTACYANIN. (1964) (43)
- Pyrophosphate Formation from Acetyl Phosphate and Orthophosphate Anions in Concentrated Aqueous Salt Solutions Does Not Provide Evidence for a Metaphosphate Intermediate (1986) (42)
- Adenosine 5'-triphosphate at the active site accelerates binding of calcium to calcium adenosinetriphosphatase. (1984) (41)
- Optical rotatory dispersion of G-actin. (1962) (40)
- Thiazolium C(2)-proton exchange: general-base catalysis, direct proton transfer, and acid inhibition (1989) (40)
- Imine-forming elimination reactions. 2. Imbalance of charge distribution in the transition state for carbinolamine dehydration (1977) (40)
- Pig liver esterase. Some kinetic properties. (1969) (39)
- Acetyl phosphate as a substrate for the calcium ATPase of sarcoplasmic reticulum. (1987) (39)
- MECHANISM OF ENZYME ACTION. (1963) (39)
- Mechanism and catalysis of 2-methyl-3-thiosemicarbazone formation. Second change in rate-determining step and evidence for a stepwise mechanism for proton transfer in a simple carbonyl addition reaction (1973) (39)
- Reactions of acetylimidazole and acetylimidazolium ion with nucleophilic reagents. Structure-reactivity relations (1971) (37)
- Role of binding energy with coenzyme A in catalysis by 3-oxoacid coenzyme A transferase. (1995) (37)
- Hydrolysis of benzaldehyde O,S-acetals (1979) (37)
- Electrophilic Catalysis. The Hydrolysis of Phosphoramidate (1964) (37)
- Mechanisms for enforced general acid catalysis of the addition of thiol anions to acetaldehyde (1977) (37)
- Non-enzymic reactions of acyl adenylate and imidazole. (1957) (36)
- Diffusion-controlled and concerted base catalysis in the decomposition of hemithioacetals (1969) (36)
- Lanthanum inhibits steady-state turnover of the sarcoplasmic reticulum calcium ATPase by replacing magnesium as the catalytic ion. (1990) (36)
- LIFETIMES OF IMINIUM IONS IN AQUEOUS SOLUTION (1995) (35)
- Nonlinearity in buffer-rate relations. Significance of carboxylate-acid complexes (1975) (35)
- How does a reaction change its mechanism. General base catalysis of the addition of alcohols to 1-phenylethyl carbocations (1986) (34)
- The Reaction of Hydroxylamine with Amides. Kinetic Evidence for the Existence of a Tetrahedral Addition Intermediate (1964) (34)
- Base Catalysis of the Reaction of Secondary Amines with p-Nitrophenyl Phosphate. Kinetic Evidence for an Addition Intermediate in Nucleophilic Aromatic Substitution1 (1965) (33)
- Reactions of acetylimidazole and acetylimidazolium ion with nucleophilic reagents. Mechanisms of catalysis (1971) (33)
- General base catalysis of the addition of hydroxylic reagents to unstable carbocations and its disappearance (1984) (33)
- Acetyl Transfer Reactions of 1-Acetyl-3-methylimidazolium Chloride1 (1961) (33)
- Thiazolium C(2)-proton exchange: isotope effects, internal return, and a small intrinsic barrier (1989) (33)
- Aminolysis of benzoyl fluorides in water (1989) (32)
- Effect of concentrated salt solutions on a merocyanine dye, a vinylogous amide (1969) (32)
- What everyone wanted to know about tight binding and enzyme catalysis, but never thought of asking. (1980) (31)
- The Nucleophilic Reactivity of Alcoholate Anions Toward p-Nitrophenyl Acetate (1962) (31)
- General-acid and general-base catalysis of the cleavage of .alpha.-D-glucopyranosyl fluoride (1991) (31)
- Unstable carbanions. General acid catalysis of the cleavage of 1-phenylcyclopropanol and 1-phenyl-2-arylcyclopropanol anions (1979) (31)
- Urea synthesis from amines and cyanic acid: kinetic evidence for a zwitterionic intermediate (1974) (31)
- "Orbital steering", entropy, and rate accelerations. (1974) (30)
- The effects of magnesium2+, hydrogen bonding, and steric factors on rate and equilibrium constants for phosphoryl transfer between carboxylate ions and pyridines (1990) (30)
- Bifunctional catalysis of the enolization of acetone (1975) (30)
- Mechanism of partitioning of the intermediates formed in the hydrolysis of phenyl imidates (1974) (30)
- Structure-reactivity correlations and general acid-base catalysis in enzymic transacylation reactions. (1972) (29)
- GENERAL ACID CATALYSIS OF THE AMINOLYSIS OF PHENYL ACETATE BY A PREASSOCIATION MECHANISM (1978) (29)
- UNSTABLE CARBANIONS. GENERAL ACID CATALYSIS OF THE CLEAVAGE OF 1‐PHENYLCYCLOPROPANOL AND 1‐PHENYL‐2‐ARYLCYCLOPROPANOL ANIONS (1979) (28)
- The reaction of carbanions with N,S-diacetylcysteamine. A model for enzymatic carbon--carbon condensation. (1965) (27)
- Concerted bimolecular substitution reactions of acetal derivatives of propionaldehyde and benzaldehyde (1989) (27)
- Formation of active site thiol esters of CoA transferase and the dependence of catalysis on specific binding interactions. (1982) (27)
- Binding of Ca2+ to the calcium adenosinetriphosphatase of sarcoplasmic reticulum. (1988) (27)
- Does dissociation of amine water complexes depend upon amine basicity? Proton exchange between quinuclidinium ions and solvent (1991) (27)
- Intramolecular general base catalysis in the aminolysis of acetylimidazole and methyl formate by diamines (1972) (27)
- The Free Energies of Hydrlysis of Some Esters and Thiol Esters of Acetic Acid (1964) (26)
- Two-step internalization of calcium from a single E.apprx.P.cntdot.Ca2 species by the calcium ATPase (1988) (26)
- General Base Catalysis of Ester Hydrolysis. (1993) (26)
- The Effect of o-Substituents on Benzaldehyde Semicarbazone Formation1 (1961) (25)
- Dissociation of calcium from the phosphorylated calcium-transporting adenosine triphosphatase of sarcoplasmic reticulum: kinetic equivalence of the calcium ions bound to the phosphorylated enzyme. (1991) (25)
- MECHANISM AND CATALYSIS OF THE HYDROLYSIS OF A FORMAMIDINIUM COMPOUND. (1967) (24)
- Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3'-phosphate 5'-diphosphate. (1986) (24)
- Base-catalyzed halogenation of acetone (1982) (24)
- LIFETIME OF AN ALIPHATIC IMINIUM ION IN AQUEOUS SOLUTION (1995) (24)
- Phosphoryl transfer between pyridines (1983) (24)
- Solvolysis of benzylazoxy tosylate and the effect of added bases and nucleophiles in aqueous trifluoroethanol and aqueous acetonitrile (1987) (23)
- General acid and base catalysis of the reversible addition of hydrogen peroxide to aldehydes (1968) (23)
- Binding of two Sr2+ ions changes the chemical specificities for phosphorylation of the sarcoplasmic reticulum calcium ATPase through a stepwise mechanism. (1992) (23)
- Coenzyme A Transferase ISOLATION AND PROPERTIES OF AN ENZYME-COENZYME A INTERMEDIATE (1967) (22)
- Catalysis of transimination through trapping by acids and bases (1977) (22)
- Elimination reactions of .beta.-cyano thioethers: evidence for a carbanion intermediate and a change in rate-limiting step (1988) (22)
- What is a Coupled Vectorial Process (1983) (22)
- Catalysis of the methoxyaminolysis of phenyl acetate by a preassociation mechanism with a solvent isotope effect maximum (1981) (22)
- Effect of denaturing agents of the urea-guanidinium class on the solubility of acetyltetraglycine ethyl ester and related compounds. (1963) (22)
- GENERAL BASE CATALYSIS OF THIOSEMICARBAZONE FORMATION. (1969) (21)
- Catalysis of transimination by rate-limiting proton transfer to buffer bases (1980) (21)
- Acetyl coenzyme A: arylamine acetyltransferase. Measurement of the steady state concentration of the acetyl-enzyme intermediate. (1972) (21)
- Utilization of the inactivation rate of coenzyme A transferase by thiol reagents to determine properties of the enzyme-CoA intermediate. (1976) (21)
- Mechanism and catalysis of the hydrolysis of methenyltetrahydrofolic acid (1967) (21)
- Acetylpyridinium ion intermediate in pyridine-catalyzed acyl transfer (1969) (21)
- Evolution on fast-forward (1992) (20)
- The aminolysis of methyl formate with aniline: evidence for catalysis by a trapping mechanism (1988) (20)
- Mechanism of hydrolysis of a phthalimidium cation. Direct observation and trapping of the tetrahedral addition intermediate and the effect of strong acid on rate and equilibrium constants of the reversible reaction (1974) (20)
- Elimination reactions of N-[2-(p-nitrophenyl)ethyl]alkylammonium ions by an E1cB mechanism (1983) (20)
- On the Mechanism of ATP‐Driven Ca2+ Transport by the Calcium ATPase of Sarcoplasmic Reticulum (1992) (20)
- Mechanism of formation and breakdown of amine tetrahedral addition compounds of a phthalimidium cation. Relative leaving group abilities of amines and alkoxide ions (1974) (20)
- The kinetics for the phosphoryl transfer steps of the sarcoplasmic reticulum calcium ATPase are the same with strontium and with calcium bound to the transport sites. (1992) (20)
- Catalysis of the hydrolysis of phosphorylated pyridines by alkaline phosphatase has little or no dependence on the pKa of the leaving group. (1993) (19)
- CONCERTED BIFUNCTIONAL PROTON TRANSFER AND GENERAL-BASE CATALYSIS IN THE METHOXYAMINOLYSIS OF PHENYL ACETATE (1981) (19)
- Concerted SN2 displacement reactions of 1-phenylethyl chlorides (1982) (19)
- 11 Coenzyme A Transferases (1973) (19)
- Lumenal and cytoplasmic binding sites for calcium on the calcium ATPase of sarcoplasmic reticulum are different and independent. (1994) (18)
- Mechanism of general acid-base catalysis of the breakdown and formation of tetrahedral addition compounds from alcohols and a phthalimidium cation. Dependence of Broensted slopes on alcohol acidity (1974) (18)
- GENERAL ACID CATALYZED BREAKDOWN OF KETONE BISULFITES (1978) (17)
- Is hydrocyanic acid a normal acid? Proton transfer from hydrocyanic acid to bases and small inhibition of proton exchange by acid (1985) (17)
- Reactions of Anionic Nucleophiles with α-D-Glucopyranosyl Fluoride in Aqueous Solution Through a Concerted, ANDN (SN2) Mechanism. (1992) (17)
- General base and acid catalysis in the hydrazinolysis of acetylimidazole (1972) (16)
- Catalysis of the reversible elimination reactions of substituted N-(.beta.-phenylethyl)quinuclidinium ions in aqueous solution (1980) (16)
- There is only one phosphoenzyme intermediate with bound calcium on the reaction pathway of the sarcoplasmic reticulum calcium ATPase. (1995) (16)
- Nonenforced concerted general-acid catalysis of the dehydration step in formaldehyde thiosemicarbazone formation (1980) (16)
- Phosphorylation of the calcium-transporting adenosinetriphosphatase by lanthanum ATP: rapid phosphoryl transfer following a rate-limiting conformational change. (1990) (15)
- Elimination reactions of .beta.-cyano thioethers: internal return and the lifetime of the carbanion intermediate (1988) (15)
- Concerted general base and bifunctional general acid catalysis of the aminolysis of phenyl acetate by pyrazole (1987) (15)
- The binding of ATP and Mg2+ to the calcium adenosinetriphosphatase of sarcoplasmic reticulum follows a random mechanism. (1993) (15)
- The free energy of hydrolysis of acetic anhydride. (1966) (15)
- EQUILIBRIUM CONSTANTS FOR THE SYNTHESIS OF HYDROXAMIC ACIDS. (1963) (15)
- Proton abstraction from dimethyl(2-substituted 9-fluorenyl)sulfonium ions. Evidence for changes in transition-state structure (1990) (15)
- Interactions of salts and denaturing agents with a polyacrylamide gel. (1969) (14)
- Base-catalyzed hemithioacetal decomposition at a diffusion-controlled rate (1967) (14)
- Acid and base catalysis of urea synthesis: nonlinear Brønsted plots consistent with a diffusion-controlled proton-transfer mechanism and the reactions of imidazole and N-methylimidazole with cyanic acid (1974) (14)
- Isolation of an enzyme-coenzyme A intermediate from succinyl coenzyme A-acetoacetate coenzyme A transferase. (1967) (14)
- Structure of Pyruvate in Aqueous Solution (1958) (13)
- General acid catalysis of the reversible addition of thiolate anions to cyanamide (1997) (13)
- Rate-limiting diffusion-controlled proton transfer in an acetyl transfer reaction (1968) (13)
- Swain-Scott correlations for reactions of nucleophilic reagents and solvents with secondary substrates (1986) (13)
- Reaction of thiols with acetylimidazole. Evidence for independent reaction pathways (1971) (13)
- Oxygen exchange into 2-butanol and hydration of 1-butene do not proceed through a common carbocation intermediate (1987) (13)
- Phosphorylation of the sodium--potassium adenosinetriphosphatase proceeds through a rate-limiting conformational change followed by rapid phosphoryl transfer. (1996) (12)
- Reaction mechanisms, catalysis, and movement (1994) (12)
- THE CHYMOTRYPSIN-CATALYZED HYDROLYSIS AND SYNTHESIS OF N-ACETYL-L-TYROSINE HYDROXAMIC ACID. (1964) (11)
- General acid-base catalysis of carbonyl and acyl group reactions (1977) (11)
- Decreasing Reactivity with Increasing Nucleophile Basicity. The Effect of Solvation on βnuc for Phosphoryl Transfer to Amines. (1986) (11)
- THE MECHANISM OF THE AMINOLYSIS OF ACETATE ESTERS (1975) (11)
- Identification of an enzyme-gamma-glutamyl coenzyme A intermediate from coenzyme A transferase. (1969) (11)
- Effects of Solvation on Nucleophilic Reactivity in Hydroxylic Solvents: Decreasing Reactivity with Increasing Basicity (1987) (11)
- Properties and mechanisms for the interconversion of the E and Z isomers of phenyl N-methylacetimidates (1974) (11)
- Elimination reactions: experimental confirmation of the predicted elimination of (.beta.-cyanoethyl)sulfonium ions through a concerted, E2 mechanism (1990) (11)
- [63] Activating enzymes for higher fatty acids (1962) (11)
- Structure and mechanism in complex general acid-base catalyzed reactions (1975) (10)
- The mechanism of the reaction of hydroxylamine with activated acyl groups. (1958) (10)
- EQUILIBRIUM CONSTANTS FOR THE INTERCONVERSION OF SUBSTITUTED 1-PHENYLETHYL ALCOHOLS AND ETHERS. A MEASUREMENT OF INTRAMOLECULAR ELECTROSTATIC INTERACTIONS (1985) (10)
- Changes of selectivity in the reactions of substituted 4-nitrobenzyl sulfonates with nucleophilic reagents (1989) (10)
- Concerted Bimolecular Substitution Reactions of Anilino Thioethers (1995) (10)
- Effect of carnosine on glycolysis. (1959) (10)
- Secondary. cap alpha. -deuterium isotope effects for the cleavage of formaldehyde hemiacetals through concerted and specific-base-catalyzed pathways (1980) (9)
- [125] Infrared measurements in aqueous media (1963) (9)
- Inhibition of the hydrolysis of p-(dimethylamino)benzoyl fluoride by potassium fluoride (1987) (9)
- The mechanism of coupling chemical and physical reactions by the calcium ATPase of sarcoplasmic reticulum and other coupled vectorial systems (1995) (9)
- Uncatalyzed aminolysis of acetylimidazole. Limiting product-like transition state for acyl transfer (1972) (9)
- Structure-reactivity coefficients for general acid catalysis of semicarbazone formation (1978) (9)
- Lifetimes of Imidinium Ions in Aqueous Solution (1997) (8)
- Nonenforced catalysis of the bisulfite carbonyl addition reaction by hydrogen bonding (1977) (8)
- Mechanism of general acid catalysis of the aminolysis of an amide (1970) (8)
- Absence of a common ion effect on the hydrolysis of an .alpha.-azido ether of an aliphatic aldehyde (1988) (8)
- Large, inverse solvent isotope effects: a simple test for the E1cB mechanism (1981) (8)
- TRANSALDIMINATION REACTIONS OF PYRIDOXAL AND RELATED COMPOUNDS (1963) (8)
- The Solvolysis of 1-Acetylimidazole in Concentrated Acid and Salt Solutions (1962) (8)
- THE EFFECT OF PRESSURE ON THE SPONTANEOUS HYDROLYSIS OF ACETYL PHOSPHATE MONO-ANION AND DI-ANION AND OF ACETYL PHENYL PHOSPHATE MONO-ANION (1962) (8)
- Infrared spectra of activated acyl groups in deuterium oxide solution. (1960) (7)
- Model reactions for CoA transferase involving thiol transfer. Anhydride formation from thiol esters and carboxylic acids. (1982) (7)
- THE REACTIVITY OF NUCLEOPHILIC REAGENTS WITH FUROYL-CHYMOTRYPSIN. (1965) (7)
- The apparent absence of an acylenzyme intermediate in the chymotrypsin-catalyzed hydrolysis of acetyl-L-tryosin hydroxamic acid. (1963) (7)
- General-base catalysis of nucleophilic substitution at carbon (1989) (7)
- The Effect of Divalent Metal Ions on the Rate and Transition-State Structure of Phosphoryl-Transfer Reactions. (1987) (6)
- A depressing specific salt effect on the hydrolysis of an iminium ion (1976) (6)
- Rates of hydrolysis of two thiol esters in water (1969) (6)
- [104] Preparation and properties of acyl adenylates (1963) (6)
- Free energies of acetyl transfer from ring-substituted acetanilides (1971) (6)
- Mechanism of the cyanide-induced formation of methyl acetate from [(methoxycarbonyl)methyl]cobalamin (1982) (6)
- Modification and inactivation of CoA transferase by 2-nitro-5-(thiocyanato)benzoate. (1981) (6)
- Phosphorylation of the sodium-potassium adenosinetriphosphatase with adenosine triphosphate and sodium ion that requires subconformations in addition to principal E1 and E2 conformations of the enzyme. (1996) (6)
- MECHANISM AND CATALYSIS OF 2-METHYL-3-THIOSEMICARBAZONE FORMATION, A SECOND CHANGE IN RATE-DETERMINING STEP AND EVIDENCE FOR A STEPWISE MECHANISM FOR PROTON TRANSFER IN A SIMPLE CARBONYL ADDITION REACTION (1973) (6)
- Direct proton transfer between hydrocyanic acid and nitrogen and oxygen bases (1985) (5)
- Rules and the Economics of Energy Balance in Coupled Vectorial Processes (1982) (5)
- Nonlinear broensted relation for general acid-base catalysis of aminolysis reactions (1972) (5)
- Specificity of the sarcoplasmic reticulum calcium ATPase at the hydrolysis step. (1988) (5)
- Mechanism of the aminolysis of alkyl benzimidates (1982) (5)
- Mechanism of the base-catalyzed cleavage of imido esters to nitriles (1979) (5)
- Proton transfer reactions of sulfonium ylides: unit Broensted slopes do not require diffusion-controlled proton transfer (1988) (5)
- Second change in rate-determining step and a nonlinear Broensted relation for general base catalysis of 2-methylthiosemicarbazone formation (1972) (4)
- Reactions of acyl phosphates with carboxylate and thiol anions. Model reactions for CoA transferase involving anhydride formation. (1982) (4)
- The perils of carbonic acid and equilibrium constants (1988) (4)
- Destabilization is as important as binding (1993) (4)
- Kinetic Demonstration of a Tetrahedral Intermediate in the Hydrolysis of Diethyl Acetylmalonate and Diethyl Acetylethylmalonate1 (1965) (4)
- General-Acid and General-Base Catalysis of the Cleavage of α-D- Glucopyranosyl Fluoride (1992) (4)
- Intramolecular proton transfer through water in diamine monocations (1985) (4)
- The vectorial specificity for calcium binding to the CaATPase of sarcoplasmic reticulum is controlled by phosphorylation, not by an E‐E* conformational change (1991) (3)
- Mechanism of Solvolysis of Substituted Benzoyl Halides. (1990) (3)
- Substrate specificity for catalysis of phosphoryl transfer by the calcium ATPase of sarcoplasmic reticulum. (1994) (3)
- Swain‐Scott Correlations for Reactions of Nucleophilic Reagents and Solvents with Secondary Substrates. (1986) (3)
- Mechanism of Reactions of Monosubstituted Phosphates in Water: Appearance and Reality (1992) (3)
- Nitrous oxide as a nucleophile in the formation of a new reactive intermediate from benzyl cations in the solvolysis of benzyl azoxytosylate (1984) (3)
- IMINE-FORMING ELIMINATION REACTIONS PART 1, GENERAL BASE AND ACID CATALYSIS AND INFLUENCE OF THE NITROGEN SUBSTITUENT ON RATES AND EQUILIBRIA FOR CARBINOLAMINE DEHYDRATION (1973) (3)
- Structure‐Reactivity Correlations for Reactions of Substituted Phenolate Anions with Acetate and Formate Esters (1993) (3)
- Two-step internalization of calcium from a single E.apprx.P.cntdot.Ca2 species by the calcium ATPase [Retraction of document cited in CA108(19):163349h] (1990) (2)
- Elimination Reactions of β‐Cyano Thioethers: Evidence for a Carbanion Intermediate and a Change in Rate‐Limiting Step. (1988) (2)
- STRUCTURE‐REACTIVITY COEFFICIENTS FOR GENERAL ACID CATALYSIS OF SEMICARBAZONE FORMATION (1979) (2)
- Quantitative Approaches to Reaction Mechanisms and Catalysis. Substitution at Carbon (1996) (2)
- Additions and Corrections - On the Characterization of Transition States by Structure-Reactivity Coefficients (1978) (2)
- THE APPARENT ABSENCE OF AN ACYL-ENZYME INTERMEDIATE IN CERTAIN CHYMOTRYPSIN-CATALYZED REACTIONS--A CORRECTION. (1963) (1)
- THE MECHANISM OF PARTITIONING OF THE INTERMEDIATES FORMED IN THE HYDROLYSIS OF PHENYL IMIDATES (1975) (1)
- Mechanisms of phosphate ester cleavage. (1962) (1)
- In defence of entropy and strain as explanations for the rate enhancement shown in intramolecular reactions (1987) (1)
- IUPAC recommendations for the representation of reaction mechanisms [Erratum to document cited in CA111(18):161389j] (1990) (1)
- Elimination Reactions of β-Cyano Thioethers: Internal Return and the Lifetime of the Carbanion Intermediate (1988) (1)
- Energy-Rich Compounds and Work (1988) (1)
- Fritz Albert Lipmann. 12 June 1899 — 24 July 1986 (1999) (1)
- Phosphoryl Transfer to Anionic Oxygen Nucleophiles. Nature of the Transition State and Electrostatic Repulsion. (1990) (1)
- Comprehensive Biochemistry. Volume 2. Organic and Physical Chemistry. (1963) (1)
- The Chemistry of Biological Energy Transfer (1963) (1)
- ACID AND BASE CATALYSIS OF UREA SYNTHESIS, NONLINEAR BRONSTED PLOTS CONSISTENT WITH A DIFFUSION-CONTROLLED PROTON-TRANSFER MECHANISM AND THE REACTIONS OF IMIDAZOLE AND N-METHYLIMIDAZOLE WITH CYANIC ACID (1975) (1)
- Thiazolium C(2)-Proton Exchange: Isotope Effects, Internal Return, and a Small Intrinsic Barrier. (1989) (1)
- Elimination Reactions: Experimental Confirmation of the Predicted Elimination of (β‐Cyanoethyl)sulfonium Ions Through a Concerted E2 Mechanism (1991) (1)
- The Aminolysis of Methyl Formate with Aniline: Evidence for Catalysis by a Trapping Mechanism. (1988) (1)
- CATALYSIS OF THE REVERSIBLE ELIMINATION REACTIONS OF SUBSTITUTED N‐(β‐PHENYLETHYL)QUINUCLIDINIUM IONS IN AQUEOUS SOLUTION (1980) (1)
- On the Economics of Binding Energies (1986) (1)
- How Does ATP Make Work (1988) (1)
- SECONDARY α-DEUTERIUM ISOTOPE EFFECTS FOR THE CLEAVAGE OF FORMALDEHYDE HEMIACETALS THROUGH CONCERTED AND SPECIFIC-BASE-CATALYZED PATHWAYS (1981) (0)
- Two-step internalization of Ca2+ from a single E approximately P.Ca2 species by the Ca2+-ATPase. (1988) (0)
- Converted Bimolecular Substitution Reactions of Acetal Derivatives of Propionaldehyde and Benzaldehyde. (1990) (0)
- RNA catalysis. Evolution on fast-forward. (1992) (0)
- Concerted General Base and Bifunctional General Acid Catalysis of the Aminolysis of Phenyl Acetate by Pyrazole. (1988) (0)
- Additions and Corrections - The Effect of Concentrated Salt Solutions on the Activity Coefficient of Acetyltetraglycine Ethyl Ester. (1965) (0)
- Entropic Contributions toRateAccelerations inEnzymicand Intramolecular Reactions andtheChelate Effect (1971) (0)
- Additions and Corrections - Elimination Reactions of N-(2-p-Nitrophenyl)ethyl) alkyl-ammonium Ions by an E1cB Mechanism (1983) (0)
- The vectorial specificity for calcium binding to the CaATPase of sarcoplasmic reticulum is controlled by phosphorylation, not by an E—E* conformational change (2001) (0)
- UREA SYNTHESIS FROM AMINES AND CYANIC ACID, KINETIC EVIDENCE FOR A ZWITTERIONIC INTERMEDIATE (1975) (0)
- Proton Abstraction from Dimethyl(2-substituted-9-fluorenyl)sulfonium Ions. Evidence for Changes in Transition-State Structure. (1990) (0)
- Lifetimes of Oxocarbenium Ions in Aqueous Solution from Common Ion Inhibition of the Solvolysis of α-Azido Ethers by Added Azide Ion. (1990) (0)
- European Biochemical Societies: Structure and Activity of Enzymes . A symposium (London), March 1964. T. W. Goodwin, J. I. Harris, and B. S. Hartley, Eds. Academic Press, New York, 1964. viii + 190 pp. Illus. $6. (1965) (0)
- Structure and Activity of Enzymes. A symposium (London), March 1964. T. W. Goodwin, J. I. Harris, and B. S. Hartley, Eds. Academic Press, New York, 1964. viii + 190 pp. Illus. $6 (1965) (0)
- Additions and Corrections - Structure-Reactivity Coefficients for General Acid Catalysis of Semicarbazone Formation (1978) (0)
- Nate at Brandeis (1987) (0)
- Vol . 6 o ORCINOL REACTION OF MONOSACCHARIDES 205 (0)
- Reply to comments by Professor Olah on "IUPAC recommendations for the representation of reaction mechanisms" (1990) (0)
- Oxygen Exchange Into 2-Butanol and Hydration of 1-Butene Do Not Proceed Through a Common Carbocation Intermediate. (1987) (0)
- Thiazolium C(2)-Proton Exchange: General-Base Catalysis, Direct Proton Transfer, and Acid Inhibition. (1989) (0)
- Additions and Corrections - The Mechanism of the Aminolysis of Methyl Formate (1969) (0)
- Direct proton transfer between hydrocyanic acid and nitrogen and oxygen bases. [Erratum to document cited in CA103(25):214716g] (1993) (0)
- ELECTROPHOREtSIS AS A QUANTITATIVE METHOD : MEASUREMENT OF ALPHA AND BETA LIPOPROTEIN CHOLESTEROL (0)
- Additions and Corrections: Decreasing Reactivity with Increasing Nucleophile Basicity. The Effect of Solvation on (nuc) for Phosphoryl Transfer to Amines. (1986) (0)
- Is HCN a Normal Acid? Proton Transfer from HCN to Bases and Small Inhibition of Proton Exchange by Acid (Kinetik des diffusionskontrollierten, pH-unabhängigen Protonenaustausches in H2O. (1986) (0)
- Direct Proton Transfer Between HCN and Nitrogen and Oxygen Bases (1986) (0)
- Book Review:Molecules and Life. Historical Essays on the Interplay of Chemistry and Biology. Joseph S. Fruton (1973) (0)
- Solvolysis of Benzyl Azoxytosylate and the Effect of Added Bases and Nucleophiles in Aqueous Trifluoroethanol and Aqueous Acetonitrile. (1987) (0)
- Absence of a Common Ion Effect on the Hydrolysis of an α‐Azido Ether of an Aliphatic Aldehyde. (1988) (0)
- Elimination Reactions of N-(2-(p-Nitrophenyl)ethyl)alkylammonium Ions by an E1cB Mechanism. (1983) (0)
- Changes of Selectivity in the Reactions of Substituted 4-Nitrobenzyl Sulfonates with Nucleophilic Reagents. (1989) (0)
- Specificity of the E-P state of the SR Ca-ATPase: implications for the coupling mechanism. (1988) (0)
- Proton-Transfer Reactions of Sulfonium Ylides: Unit Bronsted Slopes Do Not Require Diffusion-Controlled Proton Transfer. (1989) (0)
- How Does a Reaction Change Its Mechanism? General Base Catalysis of the Addition of Alcohols to 1-Phenylethyl Carbocations. (1987) (0)
- INTRINSIC BINDING ENERGY, ENZYMATIC CATALYSIS, AND COUPLED VECTORIAL PROCESSES (1982) (0)
- Fritz Albert Lipmann: June 12, 1899-July 24, 1986. (2006) (0)
- Role of coenzyme A in fatty acid metabolism: Discussion. (1953) (0)
- THE MECHANISM OF FORMATION AND BREAKDOWN OF AMINE TETRAHEDRAL ADDITION COMPOUNDS OF A PHTHALIMIDIUM CATION, THE RELATIVE LEAVING GROUP ABILITIES OF AMINES AND ALKOXIDE IONS (1974) (0)
- The mechanism of coupling atp hydrolysis to the transport of calcium (1989) (0)
- 284 Jencks ATP _ ADt / Cytoplasm CHEMICAL NN , ~ / VECTORIAL SPECIFICITY Eca 2 ATP SPECIFICITY 2 Ca 2 (2005) (0)
- The acyl-phosphate intermediate of the sarcoplasmic reticulum calcium ATPase reaction , formed in a brief incubation of vesicular enzyme (2001) (0)
- Two-step internalization of Ca/sup 2 +/ from a single E approx. P x Ca/sub 2/ species by the Ca/sup 2 +/-ATPase (1988) (0)
- Book reviewTracer applications for the study of organic reactions: By John G. Burr, Jr., Atomics International Division, North American Aviation, Inc. Interscience Publishers, New York, N. Y., 1957, x + 291 pp. Price $7.50 (1959) (0)
- WATER STRUCTURE AND PROTEINS DENATURATION. (1965) (0)
- General-Base Catalysis of Nucleophilic Substitution at Carbon. (1989) (0)
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