Wim b. Van Den Berg

Wim b. Van Den Berg's AcademicInfluence.com Rankings

Wim b. Van Den Berg

Mathematics

#5582

World Rank

#7845

Historical Rank

Probability Theory

#62

World Rank

#84

Historical Rank

mathematics Degrees

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Mathematics

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Wim b. Van Den Berg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Osteoarthritis cartilage histopathology: grading and staging. (2006) (1775)
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. (2010) (1429)
Synovial tissue inflammation in early and late osteoarthritis (2005) (879)
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. (2004) (748)
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. (1996) (512)
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. (2008) (491)
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. (2010) (488)
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. (1999) (487)
Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. (1997) (440)
The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models (2004) (430)
IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis1 (2001) (428)
Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. (1995) (399)
Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? (2012) (396)
Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. (1994) (361)
IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance 1 (2003) (348)
The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. (2010) (343)
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. (2014) (339)
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. (2004) (339)
IL-32, a proinflammatory cytokine in rheumatoid arthritis. (2006) (335)
The macrophage mannose receptor induces IL-17 in response to Candida albicans. (2009) (330)
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. (2002) (328)
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis (2001) (327)
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. (2004) (327)
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. (2005) (312)
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. (2007) (309)
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. (2009) (304)
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. (2007) (300)
Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. (1998) (297)
Th1/Th2 cytokine balance in arthritis. (1997) (297)
Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. (2012) (295)
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. (2000) (294)
TNF-induced structural joint damage is mediated by IL-1 (2007) (287)
Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. (2001) (286)
Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. (2002) (282)
Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis1 (2006) (278)
Osteophytes: relevance and biology. (2007) (274)
Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice1 (2009) (265)
TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. (2009) (255)
Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. (2011) (248)
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. (2001) (239)
Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid Differentiation Factor 88 (2003) (227)
Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair (2002) (225)
Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation (2006) (221)
Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. (2000) (214)
Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein (1989) (214)
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. (2009) (207)
Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. (2005) (198)
Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee. (1997) (194)
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis (1999) (194)
Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. (2003) (191)
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. (2003) (188)
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. (2012) (186)
Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. (2005) (186)
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. (2004) (184)
Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models. (2015) (181)
IL-17 produced by Paneth cells drives TNF-induced shock (2008) (180)
Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro. (2001) (178)
Chondrocyte behavior in fibrin glue in vitro. (1993) (175)
The anti-CD20 antibody rituximab reduces the Th17 cell response. (2011) (172)
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. (2012) (169)
Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. (1989) (169)
Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering. (2002) (168)
Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. (2009) (166)
Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis. (1990) (164)
Dual role of IL-12 in early and late stages of murine collagen type II arthritis. (1997) (162)
Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1–Driven Th17 Response (2014) (155)
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats. (2001) (153)
Resurfacing potential of heterologous chondrocytes suspended in fibrin glue in large full-thickness defects of femoral articular cartilage: an experimental study in the goat. (1999) (149)
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. (2005) (148)
Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification. (2011) (145)
12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis (2009) (144)
The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. (2004) (144)
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis. (1998) (143)
Insulin-like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid. (1989) (142)
Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-β (2015) (140)
Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits. (2003) (139)
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints. (2005) (138)
Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis (2006) (137)
Recommendations for the use of preclinical models in the study and treatment of osteoarthritis. (2010) (135)
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis. (1999) (133)
Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis. (2011) (133)
Th17 cells and IL-17 a--focus on immunopathogenesis and immunotherapeutics. (2013) (130)
Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. (1984) (129)
Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice. (1997) (127)
Interleukin-17 Acts Independently of TNF-α under Arthritic Conditions1 (2006) (127)
An IFN-γ-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis (2000) (126)
Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation. (1998) (125)
Novel therapeutic targets in rheumatoid arthritis. (2015) (124)
Osteoarthritis year 2010 in review: pathomechanisms. (2011) (124)
Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. (1998) (124)
Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts (2016) (123)
Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis (2012) (123)
Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo. (1993) (122)
Effects of treatment with a fully human anti-tumour necrosis factor α monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFα in patients with rheumatoid arthritis (2001) (119)
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis. (2003) (119)
CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative (2008) (117)
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis (2015) (115)
Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. (2001) (115)
Differential effects of IGF-1 and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. (1998) (115)
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction (2016) (112)
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. (2008) (111)
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling (2007) (110)
Cytokine targeting in osteoarthritis. (2007) (109)
Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice (2012) (109)
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. (2008) (109)
Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. (2000) (106)
Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade (2010) (105)
Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritis (2011) (105)
Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. (2004) (104)
Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. (2007) (104)
TGF-beta and osteoarthritis. (2007) (104)
In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences. (1994) (103)
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. (2003) (102)
Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1. (2005) (101)
Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone. (1998) (100)
Animal models for arthritis: innovative tools for prevention and treatment (2011) (100)
Role of tumour necrosis factor α in experimental arthritis: separate activity of interleukin 1β in chronicity and cartilage destruction (1999) (99)
Chondrocyte behaviour within different types of collagen gel in vitro. (1995) (99)
Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis. (1992) (99)
Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. (1995) (98)
Requirement of IL-17 Receptor Signaling in Radiation-Resistant Cells in the Joint for Full Progression of Destructive Synovitis1 (2005) (96)
Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors (2004) (95)
Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice. (2006) (94)
Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA) (2008) (94)
Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content. (1997) (94)
Chondrocyte-seeded hydroxyapatite for repair of large articular cartilage defects. A pilot study in the goat. (1998) (93)
Bartonella quintana Lipopolysaccharide Is a Natural Antagonist of Toll-Like Receptor 4 (2007) (93)
Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. (2011) (92)
Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis. (2003) (91)
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase. (2003) (91)
GM-CSF as a therapeutic target in inflammatory diseases. (2013) (90)
Growth factors and cartilage repair. (2001) (89)
An experimental model for hydrogen peroxide-induced tissue damage. Effects of a single inflammatory mediator on (peri)articular tissues. (1986) (89)
Role of interleukin 1 in antigen-induced exacerbations of murine arthritis. (1995) (89)
TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7 (2006) (89)
IL-1αβ Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-α Blockade Only Ameliorates Joint Inflammation (1999) (88)
T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17. (2008) (87)
Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. (2004) (87)
Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells. (2012) (87)
S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis. (2011) (83)
Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction. (2004) (83)
Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice. (1985) (83)
Role of Interleukin 17 in Arthritis Chronicity through Survival of Synoviocytes via Regulation of Synoviolin Expression (2010) (82)
Intra‐articular IL‐10 gene transfer regulates the expression of collagen‐induced arthritis (CIA) in the knee and ipsilateral paw (2000) (82)
Uncoupling of inflammatory and destructive mechanisms in arthritis. (2001) (80)
Animal models of arthritis in NOS2-deficient mice. (1999) (80)
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis (2007) (79)
Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. (2002) (79)
Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations (2000) (78)
Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis. (2000) (77)
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice. (1999) (77)
Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis (2017) (76)
In vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice. (1991) (76)
Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. (1996) (74)
TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Abrogating the Type I IFN Amplification Loop1 (2009) (74)
To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy. (2010) (74)
Influence of heme oxygenase 1 modulation on the progression of murine collagen-induced arthritis. (2005) (74)
Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels. (2014) (74)
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. (2005) (73)
The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis (1999) (72)
In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. (1993) (72)
Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. (2011) (71)
Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage. (1992) (71)
The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. (2006) (71)
Interleukin 32 (IL-32) Contains a Typical α-Helix Bundle Structure That Resembles Focal Adhesion Targeting Region of Focal Adhesion Kinase-1* (2011) (70)
Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype (2014) (70)
Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection. (2000) (70)
Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. (1998) (69)
Hydrogen peroxide suppresses the proteoglycan synthesis of intact articular cartilage. (1985) (69)
Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation. (2006) (68)
Survival and Biodistribution of Xenogenic Adipose Mesenchymal Stem Cells Is Not Affected by the Degree of Inflammation in Arthritis (2015) (68)
The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes. (2003) (65)
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis (2008) (65)
Anabolic and destructive mediators in osteoarthritis. (2000) (64)
Pathogenesis of joint damage in rheumatoid arthritis: evidence of a dominant role for interleukin-I. (1999) (64)
Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression. (2005) (63)
Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis (2017) (63)
Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor. (1987) (63)
Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls. (1988) (62)
Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis (2013) (62)
Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor α-independent mouse model (2008) (62)
Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. (2014) (61)
IL-4 and IL-13, But Not IL-10, Protect Human Synoviocytes from Apoptosis1 (2001) (61)
Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression. (2012) (60)
Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death. (2012) (60)
Differential role of IL‐18 and IL‐12 in the host defense against disseminated Candida albicans infection (2003) (59)
Amplifying elements of arthritis and joint destruction (2007) (59)
Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage (1999) (59)
Inhibition of TNFα during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNFα blockade in rheumatoid arthritis (2004) (59)
FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA) (2000) (58)
Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis. (2003) (57)
Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's? (2010) (57)
Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice (2002) (56)
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation. (2009) (54)
Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells. (2003) (54)
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist. (2005) (53)
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra. (2008) (52)
Antigen handling in antigen-induced arthritis in mice: an autoradiographic and immunofluorescence study using whole joint sections. (1982) (52)
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium (2016) (52)
Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage. (1997) (52)
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction. (1999) (52)
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice (2006) (51)
The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. (2012) (51)
Anti IL‐17A therapy inhibits bone loss in TNF‐α‐mediated murine arthritis by modulation of the T‐cell balance (2012) (50)
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis. (2013) (50)
Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage. (2015) (50)
Treatment of rats with monoclonal anti‐CD4 induces long‐term resistance to streptococcal cell wall‐induced arthritis (1992) (50)
A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis (2010) (48)
The impact of protein size and charge on its retention in articular cartilage. (1987) (48)
Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences. (1993) (47)
The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions. (2008) (47)
High susceptibility of human articular cartilage glycosaminoglycan synthesis to changes in inorganic sulfate availability (1990) (47)
Liposomal Targeting of Prednisolone Phosphate to Synovial Lining Macrophages during Experimental Arthritis Inhibits M1 Activation but Does Not Favor M2 Differentiation (2013) (47)
Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways (2001) (47)
Phenotypic differences in murine chondrocyte cell lines derived from mature articular cartilage. (2002) (46)
High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis? (2016) (46)
Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis. (1994) (45)
Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis. (2017) (45)
Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae. (1992) (45)
Inflammatory Role of ASC in Antigen-Induced Arthritis Is Independent of Caspase-1, NALP-3, and IPAF1 (2009) (44)
S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis. (2010) (44)
The Inhibitory FcγIIb Receptor Dampens TLR4-Mediated Immune Responses and Is Selectively Up-regulated on Dendritic Cells from Rheumatoid Arthritis Patients with Quiescent Disease1 (2009) (44)
Murine antigen-induced arthritis. (2007) (44)
Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB. (2008) (44)
Early elevation of transforming growth factor-beta, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion. (1997) (43)
Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in r (2015) (43)
Ebselen: a new approach to the inhibition of peroxide-dependent inflammation. (1987) (43)
Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis. (2016) (42)
Translational Mini‐Review Series on Th17 Cells: Are T helper 17 cells really pathogenic in autoimmunity? (2010) (41)
Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis. (2000) (41)
Toll‐like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs? (2011) (41)
Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis. (1997) (40)
Towards a role of interleukin-32 in atherosclerosis. (2013) (40)
Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation. (2014) (40)
High-resolution multipinhole single-photon-emission computed tomography in experimental and human arthritis. (2006) (40)
Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors. (1994) (40)
The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model. (2010) (39)
Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation (2005) (39)
Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis. (2011) (39)
Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice. (1996) (39)
Exacerbation of antigen-induced arthritis after challenge with intravenous antigen. (1983) (39)
Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing. (2008) (38)
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis (2005) (37)
Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study. (1988) (37)
Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis. (1995) (36)
Lessons from animal models of arthritis. (2002) (36)
IL-32γ and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2 (2010) (36)
Neurovascular plasticity in the knee joint of an arthritic mouse model (2000) (36)
Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. (1995) (36)
Lessons from animal models of osteoarthritis. (2001) (36)
Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex–mediated arthritis (2001) (36)
Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen: effects of pre-treatment with cobra venom factor and anti-lymphocyte serum. (1984) (35)
The role of macrophages in chronic arthritis. (1996) (35)
Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis. (2011) (34)
Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis (1999) (34)
Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation. (2016) (34)
Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors. (2016) (34)
Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration. (2001) (34)
Dendritic cells, Fcγ receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis (2005) (34)
Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis (1999) (34)
Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis (2014) (34)
Disease-Dependent Local IL-10 Production Ameliorates Collagen Induced Arthritis in Mice (2012) (33)
Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice. (2003) (33)
Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation (2011) (33)
C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene. (2002) (33)
Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen: studies on the characteristics of and mechanisms involved in the reaction. (1984) (33)
Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance. (1994) (32)
Flare-up of antigen-induced arthritis in mice after challenge with oral antigen. (1984) (32)
Destructive Arthritis in the Absence of Both FcγRI and FcγRIII1 (2008) (32)
Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis. (1998) (32)
Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation. (1990) (31)
Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fcγ receptors on myeloid precursor cells (2012) (31)
In vivo evidence for a key role of IL-1 in cartilage destruction in experimental arthritis. (1991) (31)
Anti-cytokine therapy in chronic destructive arthritis (2000) (31)
Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I. (1993) (31)
TNF alpha and IL-1 beta are separate targets in chronic arthritis. (1999) (31)
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis. (2008) (31)
Sequential alterations of periarticular structures in antigen-induced arthritis in mice. Histological observations on fibrous capsule, ligaments, bone and muscles, using whole joint sections. (1983) (31)
Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models (2018) (31)
Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. (2000) (30)
Milk‐Derived Nanoparticle Fraction Promotes the Formation of Small Osteoclasts But Reduces Bone Resorption (2017) (30)
The role of mast cells in antigen induced arthritis in mice. (1988) (30)
The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis (2015) (30)
Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators. (2002) (29)
WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis. (2017) (29)
Secukinumab for rheumatology: development and its potential place in therapy (2016) (28)
Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis (2016) (28)
Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients? (2004) (28)
In Vivo Molecular Imaging of Cathepsin and Matrix Metalloproteinase Activity Discriminates between Arthritic and Osteoarthritic Processes in Mice (2014) (27)
Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage. (1994) (27)
T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization. (2012) (27)
Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium (2011) (27)
Animal models of arthritis. What have we learned? (2005) (27)
Proteoglycan synthesis and osteophyte formation in 'metabolically' and 'mechanically' induced murine degenerative joint disease: an in-vivo autoradiographic study. (1992) (27)
Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions. (2014) (27)
Allergic arthritis induced by cationic antigens: relationship of chronicity with antigen retention and T-cell reactivity. (1987) (27)
Safety of glucocorticoids can be improved by lower yet still effective dosages of liposomal steroid formulations in murine antigen-induced arthritis: comparison of prednisolone with budesonide. (2011) (27)
Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis. (2013) (26)
Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. (2012) (26)
Detection of intestinal flora-derived bacterial antigen complexes in splenic macrophages of rats. (1994) (26)
Laxity characteristics of normal and pathological murine knee joints in vitro (1995) (26)
Mechanisms of cell association of chloroquine to leucocytes. (1986) (26)
Correlation of the size of type II transforming growth factor beta (TGF-beta) receptor with TGF-beta responses of isolated bovine articular chondrocytes. (1993) (25)
Influence of the severity and duration of murine antigen-induced arthritis on cartilage proteoglycan synthesis and chondrocyte death. (1985) (25)
Uncoupling of inflammation and destruction in rheumatoid arthritis: myth or reality? (2005) (25)
Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis (2010) (25)
Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra (2000) (25)
Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis. (2016) (24)
Site‐specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase (1994) (24)
Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice. (2012) (23)
The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee. (1996) (23)
Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis (2015) (23)
A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis (2010) (23)
Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages (2014) (23)
Electrical charge of hyaline articular cartilage: its role in the retention of anionic and cationic proteins. (1986) (23)
Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion. (1988) (23)
Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis (2018) (22)
Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis? (1988) (22)
Analysis of changes in proteoglycan content in murine articular cartilage using image analysis. (1994) (22)
A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts (2011) (22)
Cationic immune complex arthritis in mice--a new model. Synergistic effect of complement and interleukin-1. (1992) (22)
Effects of experimental joint inflammation on bone marrow and periarticular bone. A study of two types of arthritis, using variable degrees of inflammation. (1985) (21)
Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis. (2002) (21)
Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage. (1998) (21)
Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts. (2011) (21)
A Dual Role of Upper Zone of Growth Plate and Cartilage Matrix–Associated Protein in Human and Mouse Osteoarthritic Cartilage: Inhibition of Aggrecanases and Promotion of Bone Turnover (2017) (21)
Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis. (2011) (21)
Experimental arthritis in C57black/6 normal and beige (Chediak-Higashi) mice: in vivo and in vitro observations on cartilage degradation. (1988) (21)
Determination of small quantities of sulfate (0-12 nmol) in serum, urine, and cartilage of the mouse. (1987) (20)
Effects of synovial fluid and synovial fluid cells on chondrocyte metabolism in short term tissue culture. (1988) (19)
The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40. (2008) (19)
Lessons for joint destruction from animal models. (1997) (19)
Localization and quantification of the insulin-like growth factor-1 receptor in mouse articular cartilage by confocal laser scanning microscopy. (1994) (19)
IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints. (1995) (19)
A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis (2011) (19)
Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis. (2009) (19)
Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis. (1999) (18)
Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane (2016) (18)
Inflammation in osteoarthritis: changing views. (2015) (18)
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis. (2008) (18)
Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? (2013) (18)
The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1. (2015) (18)
On the mechanisms of association of the macrolide antibiotic erythromycin with isolated human polymorphonuclear leucocytes. (1988) (18)
Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. (1981) (18)
Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis (2017) (17)
Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis. (2009) (17)
The contribution of quantitative confocal laser scanning microscopy in cartilage research: Chondrocyte insulin‐like growth factor‐1 receptors in health and pathology (1997) (17)
Insulin-like growth factor stimulation of articular chondrocyte proteoglycan synthesis. Availability and responses at different ages. (1993) (17)
Growth factors in experimental osteoarthritis: transforming growth factor beta pathogenic? (1995) (17)
Fc gamma receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis. (2006) (17)
FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis. (2003) (16)
Induction of arthritis in rats by soluble peptidoglycan-polysaccharide complexes produced by human intestinal flora. (2010) (16)
Role of synovial macrophages in experimental arthritis. (1992) (16)
Inhibition of M1 macrophage activation in favour of M2 differentiation by liposomal targeting of glucocorticoids to the synovial lining during experimental arthritis (2011) (16)
Allergic arthritis induced by cationic proteins: role of molecular weight. (1989) (16)
Characteristics of the transport of ascorbic acid into leucocytes. (1987) (16)
Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB. (2013) (16)
Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis (2017) (15)
Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat. (1994) (15)
Low heme oxygenase-1 levels in patients with systemic sclerosis are associated with an altered Toll-like receptor response: another role for CXCL4? (2016) (15)
An experimental model for hydrogen peroxide induced tissue damage: effect on cartilage and other articular tissues. (1987) (15)
Exposure to Candida albicans Polarizes a T-Cell Driven Arthritis Model towards Th17 Responses, Resulting in a More Destructive Arthritis (2012) (15)
Fate of antigen after intravenous and intraarticular injection into mice. Role of molecular weight and charge. (1989) (15)
Age- and sex-related differences in antigen-induced arthritis in C57Bl/10 mice. (1989) (15)
Is there a rationale for combined TNF and IL-1 blocking in arthritis? (2002) (14)
Arthritis by autoreactive T cell lines obtained from rats after injection of intestinal bacterial cell wall fragments. (1992) (14)
Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis. (2013) (14)
Fc Gamma Receptor IIb on GM-CSF Macrophages Controls Immune Complex Mediated Inhibition of Inflammatory Signals (2014) (14)
Detection and quantification of experimental joint inflammation in mice by measurement of 99mTc-pertechnetate uptake. (1981) (14)
Intravenous Delivery of HIV-Based Lentiviral Vectors Preferentially Transduces F4/80+ and Ly-6C+ Cells in Spleen, Important Target Cells in Autoimmune Arthritis (2013) (14)
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis. (1991) (14)
Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis (2011) (13)
Flare of antigen-induced arthritis in mice after intravenous challenge. Kinetics of antigen in the circulation and localization of antigen in the arthritic and noninflamed joint. (1986) (13)
Species-specific expression of type II TGF-beta receptor isoforms by articular chondrocytes: effect of proteoglycan depletion and aging. (1997) (13)
Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis. (2005) (13)
THU0037 Immune complex-induced inhibition of osteoclastogenesis is mediated via activating, but not inhibitory FCGAMMA receptors on myeloid precursor cells (2013) (13)
Electrical charge of the antigen determines its localization in the mouse knee joint. Deep penetration of cationic BSA in hyaline articular cartilage. (1985) (13)
Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation? (1993) (12)
Antigen induced arthritis in beige (Chediak-Higashi) mice. (1990) (12)
Salicylate-induced depletion of endogenous inorganic sulfate. Potential role in the suppression of sulfated glycosaminoglycan synthesis in murine articular cartilage. (1985) (12)
Is the serum amyloid A we use really serum amyloid A? Comment on the article by Connolly et al. (2013) (12)
Effects of methotrexate on glycosaminoglycan production by scleroderma fibroblasts in culture. (1993) (12)
The effect of low sulfate concentrations on the glycosaminoglycan synthesis in anatomically intact articular cartilage of the mouse (1989) (12)
The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-&bgr;1 (2018) (12)
Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions. (1987) (12)
Impaired Porphyromonas gingivalis–Induced Tumor Necrosis Factor Production by Dendritic Cells Typifies Patients With Rheumatoid Arthritis (2015) (12)
Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis. (2009) (11)
Direct effect of murine rIL-1 on cartilage metabolism in vivo. (1989) (11)
Antigen handling in antigen-induced joint inflammation: kinetics of a second intra-articularly injected dose of antigen in an already established antigen-induced joint inflammation. (1981) (11)
Transient chondrocyte nonresponsiveness to insulin-like growth factor-1 upon H2O2 exposure is not related to IGF receptor damage. (1991) (10)
Potential of modulatory cytokines in the rheumatoid arthritis process. (2001) (10)
How to build an inducible cartilage-specific transgenic mouse (2014) (10)
Immune complex formation between IgM rheumatoid factor and IgG generated by hyaluronic acid. (1989) (10)
Immunomodulation of streptococcal cell wall‐induced arthritis. Identification of inflammatory cells and regulatory T cell subsets by mercuric chloride and in vivo CD8 depletion (1992) (9)
Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis (2013) (9)
Expression of recombinant human soluble type II transforming growth factor-beta receptor in Pichia pastoris and Escherichia coli: two powerful systems to express a potent inhibitor of transforming growth factor-beta. (1998) (9)
Does TGF-beta protect articular cartilage in vivo? (1993) (9)
Synthesis of aberrant glycosaminoglycans during cartilage culture in 'sulfate free' medium. (1988) (9)
Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy (2009) (9)
Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production. (2019) (9)
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint (1993) (8)
Role of beta 2 integrins in the recruitment of phagocytic cells in joint inflammation in the rat. (1994) (8)
Alteration of chloroquine accumulation in human polymorphonuclear leucocytes under inflammatory conditions. (1987) (8)
Mechanisms of cell association of some non-steroidal anti-inflammatory drugs with isolated leucocytes. (1988) (8)
The effect of salicylate on anatomically intact articular cartilage is influenced by sulfate and serum in the culture medium. (1986) (8)
Mechanisms of cartilage destruction in joint inflammation. (1993) (8)
Association of sodium salicylate to isolated leucocytes. (1984) (7)
Crohn's disease associated with arthritis: a possible role for cross-reactivity between gut bacteria and cartilage in the pathogenesis of arthritis. (1988) (7)
Lessons from animal models of arthritis over the past decade. (2009) (7)
Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study. (1989) (7)
Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation (2018) (7)
Development of Interleukin-1 Receptor Antagonist Mutants with Enhanced Antagonistic Activity In Vitro and Improved Therapeutic Efficacy in Collagen-Induced Arthritis (2008) (7)
Joint inflammation and cartilage destruction may occur uncoupled. (1998) (7)
Modes of association of indometacin with human polymorphonuclear leucocytes. (1989) (7)
T cell responses to streptococcal antigens in rats: relation to susceptibility to streptococcal cell wall-induced arthritis. (1988) (6)
Impact of NSAID and steroids on cartilage destruction in murine antigen induced arthritis. (1991) (6)
Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system. (2003) (6)
An in vitro approach to study cellular kinetics of drugs. (1987) (6)
Role of phagocytic synovial lining cells in experimental arthritis. (1993) (5)
Antigen induced arthritis: antigen handling and chronicity of joint inflammation. (1982) (5)
Chronic inflammatory reactions in the guinea-pig peritoneal cavity induced by continuous local PPD stimulation. Immune status dependency of the accumulation of lymphocytes and eosinophils. (1980) (5)
Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase. (1994) (5)
What we learn from arthritis models to benefit arthritis patients. (2000) (5)
Cross-reactivity to proteoglycans in bacterial arthritis: lack of evidence for in vivo role in induction of disease. (1994) (5)
Induction of tolerance by T-cell vaccination is possible beyond the area of autoimmunity: down-regulation of immunity directed to foreign protein antigens. (1993) (5)
Quantitation of the changes in vascularity during arthritis in the knee joint of a mouse with a digital image analysis system (2001) (5)
Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage. (1990) (5)
Circulating immune complexes and rheumatoid arthritis: the induction of immune complex formation between rheumatoid factor and IgG by polyethylene glycol. (1989) (4)
Requirements for flare reactions of joint inflammation induced in mice by cloned MT4+, Lyt-2- T cells. (1989) (4)
Impact of NSAIDS on murine antigen induced arthritis. I. Investigation of antiinflammatory and chondroprotective effects. (1989) (4)
Reply: To PMID 23860661. (2013) (4)
Monoclonal anti-Ia antibodies suppress the flare up reaction of antigen induced arthritis in mice. (1986) (4)
Cytokines and joint erosion in arthritis. (2008) (4)
Proteomic analysis of Systemic Sclerosis serum identifies the toll-like receptor agonists S100A8/A9 as a novel possible pathogenic marker (2010) (3)
Accumulation of T cells and local antippd antibody production in lymphokine‐mediated chronic peritoneal inflammation in the guinea pig (1980) (3)
Impact of NSAIDS on murine antigen induced arthritis. II. A light microscopic investigation of antiinflammatory and bone protective effects. (1990) (3)
Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras. (1991) (3)
99mTc-pertechnetate uptake measurement in the rabbit knee-joint. II. Kinetics of 99mTcO-4 in normal and arthritic rabbit knee-joints. (1983) (3)
1.56 Synergism between GM-CSF and IL-17 causes enhanced joint pathology via the production of IL-6 and IL-23 (2014) (3)
Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models. (2004) (3)
Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis? (2009) (3)
Cytokine directed targeting in chronic arthritis. (2000) (3)
Correction: Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice (2010) (3)
Electrical charge of a protein determines penetration and localization in hyaline articular cartilage. Quantitative and autoradiographic studies on cartilage of different species, including man. (1988) (3)
Suppression of antibody-mediated accumulation of eosinophils in chronic inflammatory lesions by concomitant delayed hypersensitivity reactions. (1980) (3)
Toll-like receptor-4 signalling is specifically tak1-independent in synovial fibroblasts (2011) (2)
Site specific inhibition of cartilage proteoglycan synthesis in the murine knee joint. Differences between 3 metabolic stimuli. (1994) (2)
Variable TGF-beta receptor expression regulates TGF-beta responses of articular chondrocytes. (1993) (2)
Electrical charge and joint inflammation. Suppression of cationic aBSA-induced arthritis with a competitive polycation. (1987) (2)
A8.29 Commensal intestinal microbiota drives spontaneous interleukin-1- and T helper 17-mediated arthritis in mice (2014) (2)
Arguments for interleukin 1 as a target in chronic arthritis (2000) (2)
Quantification of morphometric changes in murine experimental osteoarthritis using image analysis. (1996) (2)
Electrical charge and joint inflammation: suppression of cationic aBSA induced arthritis with the polycation protamine. (1987) (2)
PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology (2012) (2)
A5.15 The validation of disease-inducible promoter constructs for gene therapy in rheumatoid arthritis and osteoarthritis in human THP-1 cells. (2014) (2)
Chondrocyte nonresponsiveness of arthritic articular cartilage caused by short term immobilization. (1991) (2)
SAT0006 High Systemic LDL Cholesterol Levels Lead to Synovial Activation and Strongly Accelerate Development of Ectopic Bone Formation During Experimental Osteoarthritis (2015) (2)
A1.22 IL-22 Drives the initiation and augmentation of TH17-dependent experimental arthritis (2014) (2)
Periodontal pathogens amplify arthritic bone erosion by reducing the TH2 response and promoting a toll-like receptor 2-dependent TH17 phenotype (2012) (1)
Macrophage dysfunction in Psoriatic Arthritis (2011) (1)
IL-32γ and streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2 (2010) (1)
Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg" (2001) (1)
Lessons from animal models of osteoarthritis. (2008) (1)
Stimulation of antigen-specific murine T cell clones in vitro with antigen-pulsed adherent cells fixed to a carrier. (1988) (1)
A5.14 Disease-regulated local interleukin-10 gene therapy diminishes synovitis and articular cartilage damage in experimental arthritis (2014) (1)
Dual role of IL-21 in experimental arthritis via SOCS regulation and Th17 differentiation (2011) (1)
Allergic arthritis induced by cationic proteins. (1990) (1)
Activating FCγ RECEPTORS mediate immune complex-induced inhibition of osteoclastogenesis (2012) (1)
4.8 Role of Toll-like receptor 9 in the pathogenesis of inflammatory autoimmune arthritis and osteoclast activation (2014) (1)
Pathophysiology of osteoarthritis. (2000) (1)
The Th17 Pathway as a Therapeutic Target in Rheumatoid Arthritis and Other Autoimmune and Inflammatory Disorders (2013) (1)
Short-term immobilization restores and prevents inhibition of chondrocyte synthesis caused by IL-1. (1989) (1)
Lymphokine-mediated stimulation of eosinophil migration in the guinea-pig. (1981) (1)
AB0119 BMP-9 induces both SMAD1/5/8 and SMAD2/3 phosphorylation, and specific response genes, in chondrocytes (2013) (1)
Influence of joint inflammation on chondrocyte function. (1988) (1)
NIR-fluorescence imaging points at a role for matrix-metalloproteinases in causing irreversible cartilage damage during collagen-induced arthritis (2012) (0)
Micro-RNA 155 controls the pathogenesis of autoimmune arthritis (2011) (0)
Antigen-induced arthritis: inflammation and antigen handling. (1981) (0)
Lack of TLR4 on bone marrow derived cells ameliorates experimental arthritis and decreases cd4- IL-17+ cells (2012) (0)
A9.13 systemic LDL cholesterol-accumulation during experimental oa leads to increased synovial thickening, s100a8/9 production and ectopic bone formation (2014) (0)
06.07 Disease-inducible interleukin-10 gene therapy suppresses innate cytokine response in the 3d micromass model of the synovial membrane (2017) (0)
THU0022 Enhanced expression of suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function (2013) (0)
SAT0053 Advantages of non-invasive imaging techniques in monitoring antigen induced arthritis rat model (2013) (0)
The polymorphonuclear leukocyte: its pharmacological transport and target properties: an overview. (1989) (0)
99mTc-pertechnetate uptake measurement in the rabbit knee-joint. (1981) (0)
FRI0039 Synovial Macrophages Promote TGF-Beta Signaling but Protect against Influx of S100a8/s100a9-Producing Cells Following Intra-Articular Injections of Oxidized Low-Density Lipoproteins (2016) (0)
Toll-like receptor 2 negatively regulates Fcγ receptor response in macrophages and inhibits FcγR-mediated arthritis (2011) (0)
A10.14 Inhibition of sclerostin accelerates TNFα-mediated bone destruction (2016) (0)
[Role of interleukin-1 in osteoarthritis]. (1997) (0)
Rheumatoid Arthritis is a Lining Cell Disease: An Evolving Concept (1999) (0)
FRI0022 Periodontal pathogens promote autoimmune arthritis by reducing TH2 response and inducing a toll-like receptor 2-dependent TH17 phenotype (2013) (0)
Antigen-induced arthritis: inflammation and antigen handling after two different doses of intra-articularly injected antigen. (1982) (0)
The role of MHC class II antigens in the flare up reaction of antigen-induced arthritis in mice. (1986) (0)
Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis (2017) (0)
Experimental Arthritis (2020) (0)
Sustained high expression of Fcγ receptorII (CD32) on dendritic cells (DCs) in patients with rheumatoid arthritis (RA) (2002) (0)
In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice. (2014) (0)
THU0495 IL-22 Drives the Initiation and Augmentation of TH17-Dependent Experimental Arthritis (2014) (0)
CD4+CD45RA+ T-cells from early diffuse systemic sclerosis patients produce high levels of interleukin-17 (2011) (0)
OP0122 Synovial WNT and WISP1 Expression Induces Expression of Cartilage-Degrading Metalloproteinases in the Synovium (2013) (0)
AB0111 Role of Toll-Like Receptor 9 in the Pathogenesis of Inflammatory Autoimmune Arthritis and Osteoclast Activation (2014) (0)
The role of antigen electric charge in the development of chronic arthritis. (1986) (0)
IL-21 induces socs-mediated suppression of TLR triggering but aggravates TH17-driven destructive arthritis (2012) (0)
Articular cartilage: cause or victim in arthritis. (1995) (0)
Lymphokines in sensitized rats (II). Skin reacting factors and lymphnode activating substances originating from thymocytes. (1975) (0)
FRI0053 IL-21 induces socs-mediated suppression of TLR triggering but aggravates TH17-driven destructive arthritis (2013) (0)
Modulating TLR responses in systemic sclerosis via heme oxygenase-1 (2010) (0)
Role of Cytokines in Cartilage Destruction in Experimental Arthritis (1999) (0)
07.04 Partial elimination of intestinal microbiota dampens t helper 17 cell differentiation and established collagen-induced arthritis in mice (2017) (0)
Increased innate immune responses by interleukin-22 contributes to the inflammatory process in rheumatoid arthritis (2012) (0)
FRI0044 Cholesterol accumulation by low density lipoprotein receptor deficiency or a cholesterol-rich diet enhances osteophyte formation during experimental osteoarthritis by activating transforming growth factor-beta (2013) (0)
T cell lessons from the RA synovium SCID mouse model: synovial tissue rich in CD3 T cells lacks response to CTLA4-Ig, but is successfully treated with anti-IL-17 antibodies (2011) (0)
Complications in post-bariatric body contouring surgery using a practical treatment regime to optimise the nutritional state (2022) (0)
OP0090 LDL receptor deficiency results in osteophyte formation during experimental osteoarthritis which is increased under high cholesterol conditions (2013) (0)
AB0070 Wnt and wisp1 expression in the synovium induces cartilage damage by skewing of tgf-beta signaling via the canonical wnt signaling pathway (2013) (0)
OP0024 Synovial Activation Drives Efficacy of Anti-Inflammatory Effects of Adipose-Derived Stem Cells in Experimental OA Which is Reflected by Serum Levels of S100a8/A9 (2014) (0)
Increased IL-22 expression by synovial Th17 cells during late stages of arthritis is controlled by IL-1 and enhances bone degradation (2011) (0)
Cytokine-directed targeting in chronic arthritis. (2000) (0)
FRI0005 Combination Blocking of IL-22 and IL-17 During Experimental Arthritis Potently Reduces TH17-Driven Disease Progression (2015) (0)
THU0513 Impaired Recognition of Porphyromonas Gingivalis in Rheumatoid Arthritis Patients (2014) (0)
Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: potential consequence for articular cartilage. (1990) (0)
Effect of nonsteroidal antiinflammatory drugs on cartilage destruction in antigen induced arthritis in mice. (1988) (0)
A1.81 Mincle is not essential in T-cell independent arthritis models (2014) (0)
A5.8 Synovial wnt and wisp1 expression induces expression of cartilage-degrading metalloproteinases in the synovium (2014) (0)
Triggering of FcGR during dendritic cell maturation leads to a decreased expression of the chemokines DC-CK1, ELC and TARC (2004) (0)
AB0077 RA-Patients Show Differential Responses in A Novel Cell-Based Promoter Reporter Assay (2014) (0)
Increased expression of chemokines DC-CK1, ELC and TARC by dendritic cells and in synovium from patients with rheumatoid arthritis (2004) (0)
Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis (2017) (0)
Identifying the TLR4 bearing target cell in experimental arthritis (2011) (0)
Systemically delivered glucocorticoid liposomes suppress bone erosion and inhibit osteoclast activation in synovium and bone marrow during experimental murine arthritis (2010) (0)
β2 integrins control the proinflammatory phenotype of type 1 macrophages and dendritic cells (2010) (0)
TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling (2013) (0)
AB0120 Elevated LYSYL hydroxylase 2B expression and pyridinoline cross-link formation in collagenase-induced OA; the cause of OA-related fibrosis? (2013) (0)
OP0112 Synergism between GM-CSF and IL-17 Causes Enhanced Joint Pathology via the Production of IL-6 and IL-23 (2014) (0)
IL-21R deficiency during experimental arthritis increases local expression of inflammatory mediators but protects against joint pathology by suppressing Th17 cells (2010) (0)
Chondrocyte impairment: another mechanism of cartilage destruction in chronic arthritis. (1984) (0)

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