Winfried Denk
#11,627
Most Influential Person Now
Physicist and neurobiologist
Winfried Denk's AcademicInfluence.com Rankings
Winfried Denkbiology Degrees
Biology
#713
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#1244
Historical Rank
Neuroscience
#125
World Rank
#132
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Biology Physics
Winfried Denk's Degrees
- PhD Physics University of Göttingen
Why Is Winfried Denk Influential?
(Suggest an Edit or Addition)According to Wikipedia, Winfried Denk is a German physicist. He built the first two-photon microscope while he was a graduate student in Watt W. Webb's lab at Cornell University, in 1989. Early life and education Denk was born in Munich, Germany. As a child he spent most of his playtime learning to use the tools and building materials in his father's workshop. In school it became apparent that Denk’s ‘talents were unevenly spread across subjects, math and physics being favored’. Fixing and constructing electronic devices was his main hobby throughout high school.
Winfried Denk's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Two-photon laser scanning fluorescence microscopy. (1990) (7651)
- Deep tissue two-photon microscopy (2005) (3631)
- Optical stethoscopy: Image recording with resolution λ/20 (1984) (1933)
- Serial Block-Face Scanning Electron Microscopy to Reconstruct Three-Dimensional Tissue Nanostructure (2004) (1455)
- Dendritic spines as basic functional units of neuronal integration (1995) (973)
- Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. (2004) (949)
- Connectomic reconstruction of the inner plexiform layer in the mouse retina (2013) (874)
- In vivo dendritic calcium dynamics in neocortical pyramidal neurons (1997) (824)
- Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. (1998) (801)
- Wiring specificity in the direction-selectivity circuit of the retina (2011) (747)
- Photon Upmanship: Why Multiphoton Imaging Is More than a Gimmick (1997) (705)
- Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier. (2003) (615)
- A Miniature Head-Mounted Two-Photon Microscope High-Resolution Brain Imaging in Freely Moving Animals (2001) (562)
- Directionally selective calcium signals in dendrites of starburst amacrine cells (2002) (543)
- Direct Measurement of Coupling Between Dendritic Spines and Shafts (1996) (532)
- Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. (1999) (519)
- Coincidence detection in single dendritic spines mediated by calcium release (2000) (481)
- Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo (2004) (463)
- Space-time wiring specificity supports direction selectivity in the retina (2014) (438)
- In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons (1999) (380)
- Convolutional Networks Can Learn to Generate Affinity Graphs for Image Segmentation (2010) (372)
- On the fundamental imaging-depth limit in two-photon microscopy (2004) (371)
- Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy (1994) (364)
- Imaging in vivo: watching the brain in action (2008) (359)
- The Big and the Small: Challenges of Imaging the Brain’s Circuits (2011) (356)
- Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing (2006) (336)
- Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo (2008) (332)
- The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging. (2008) (308)
- Mechanisms of Calcium Influx into Hippocampal Spines: Heterogeneity among Spines, Coincidence Detection by NMDA Receptors, and Optical Quantal Analysis (1999) (300)
- Towards neural circuit reconstruction with volume electron microscopy techniques (2006) (285)
- Two types of calcium response limited to single spines in cerebellar Purkinje cells. (1995) (282)
- Two-photon scanning photochemical microscopy: mapping ligand-gated ion channel distributions. (1994) (275)
- High-accuracy neurite reconstruction for high-throughput neuroanatomy (2011) (271)
- Axons and Synaptic Boutons Are Highly Dynamic in Adult Visual Cortex (2006) (258)
- Calcium imaging of single stereocilia in hair cells: Localization of transduction channels at both ends of tip links (1995) (258)
- High-precision automated reconstruction of neurons with flood-filling networks (2017) (250)
- Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control (2004) (249)
- Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo (1999) (242)
- Supervised Learning of Image Restoration with Convolutional Networks (2007) (234)
- Targeted Whole-Cell Recordings in the Mammalian Brain In Vivo (2003) (225)
- Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor (2008) (204)
- Visually evoked activity in cortical cells imaged in freely moving animals (2009) (203)
- Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. (2008) (194)
- Rapid Axonal Sprouting and Pruning Accompany Functional Reorganization in Primary Visual Cortex (2009) (191)
- Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo (2011) (187)
- 3D structural imaging of the brain with photons and electrons (2008) (183)
- Structural neurobiology: missing link to a mechanistic understanding of neural computation (2012) (182)
- Optical measurement of picometer displacements of transparent microscopic objects. (1990) (173)
- New developments in multiphoton microscopy (2002) (161)
- High-resolution whole-brain staining for electron microscopic circuit reconstruction (2015) (151)
- Large-Scale Automated Histology in the Pursuit of Connectomes (2011) (149)
- Eyecup scope—optical recordings of light stimulus-evoked fluorescence signals in the retina (2009) (147)
- Action potentials reliably invade axonal arbors of rat neocortical neurons. (2000) (146)
- Boundary Learning by Optimization with Topological Constraints (2010) (146)
- Near‐field optics: Microscopy with nanometer‐size fields (1991) (146)
- A Dendrite-Autonomous Mechanism for Direction Selectivity in Retinal Starburst Amacrine Cells (2007) (144)
- Staining and embedding the whole mouse brain for electron microscopy (2012) (138)
- Imaging calcium dynamics in dendritic spines (1996) (134)
- Maximin affinity learning of image segmentation (2009) (132)
- Fly motion vision is based on Reichardt detectors regardless of the signal-to-noise ratio. (2004) (121)
- Axon tracking in serial block-face scanning electron microscopy (2009) (121)
- Forward and reverse transduction at the limit of sensitivity studied by correlating electrical and mechanical fluctuations in frog saccular hair cells (1992) (120)
- Neurotechnology: Summa technologiae (2012) (119)
- High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge. (2004) (118)
- Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging (2004) (112)
- Optical recording of light-evoked calcium signals in the functionally intact retina. (1999) (110)
- Local electrical dissipation imaged by scanning force microscopy (1991) (109)
- In vivo two-photon voltage-sensitive dye imaging reveals top-down control of cortical layers 1 and 2 during wakefulness (2008) (106)
- Synthesis, photochemistry, and biological activity of a caged photolabile acetylcholine receptor ligand. (1989) (105)
- Segmentation of SBFSEM Volume Data of Neural Tissue by Hierarchical Classification (2008) (104)
- Mechanical properties of sensory hair bundles are reflected in their Brownian motion measured with a laser differential interferometer. (1989) (103)
- Alpha-Herpesvirus Infection Induces the Formation of Nuclear Actin Filaments (2006) (97)
- Globally Optimal Closed-Surface Segmentation for Connectomics (2012) (96)
- Two-photon excitation in functional biological imaging. (1996) (92)
- Determination of absolute two-photon excitation cross sections by in situ second-order autocorrelation. (1995) (87)
- The Mind of a Mouse (2020) (86)
- Progress and remaining challenges in high-throughput volume electron microscopy (2018) (84)
- Feasibility of molecular-resolution fluorescence near-field microscopy using multi-photon absorption and field enhancement near a sharp tip (1999) (81)
- Wide-range, low-operating-voltage, bimorph STM: Application as potentiometer (1986) (79)
- Dendritic processing (2001) (78)
- EM connectomics reveals axonal target variation in a sequence-generating network (2017) (78)
- Miniaturization of two-photon microscopy for imaging in freely moving animals. (2013) (77)
- Miniature random-access fiber scanner for in vivo multiphoton imaging (2007) (73)
- Contour-propagation algorithms for semi-automated reconstruction of neural processes (2008) (72)
- Multi-Photon Molecular Excitation in Laser-Scanning Microscopy (2006) (71)
- Two-photon targeted patching (TPTP) in vivo (2006) (71)
- Learning to Agglomerate Superpixel Hierarchies (2011) (70)
- Coherence-gated wave-front sensing in strongly scattering samples. (2004) (70)
- Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core. (2002) (64)
- Oscillations and gaseous oxides in invertebrate olfaction. (1996) (61)
- Two-photon optical beam induced current (OBIC) imaging through the backside of integrated circuits (1997) (60)
- High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe (2010) (57)
- A Miniature Head-Mounted Neurotechnique Two-Photon Microscope: High-Resolution Brain Imaging in Freely Moving Animals (2001) (53)
- Point-spread functions for backscattered imaging in the scanning electron microscope (2007) (50)
- 3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries (2012) (49)
- Single-protein detection in crowded molecular environments in cryo-EM images (2017) (45)
- Longitudinal spread of second messenger signals in isolated rod outer segments of lizards (1999) (45)
- Mechanical response of frog saccular hair bundles to the aminoglycoside block of mechanoelectrical transduction. (1992) (43)
- Quantitative evaluation of cross-peak intensities by projection of two-dimensional NOE spectra on a linear space spanned by a set of reference resonance lines (1986) (43)
- Combined suppression of diagonal peaks and t1 ridges in two-dimensional nuclear overhauser enhancement spectra (1985) (41)
- Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development (2006) (39)
- Comparison of one- and two-photon optical beam-induced current imaging (1999) (38)
- Automated in‐chamber specimen coating for serial block‐face electron microscopy (2013) (36)
- Volume EM Reconstruction of Spinal Cord Reveals Wiring Specificity in Speed-Related Motor Circuits. (2018) (36)
- Flood-Filling Networks (2016) (36)
- Identification of chemical synapses in the pharynx of Caenorhabditis elegans. (1997) (35)
- Second-harmonic generation imaging of membrane potential with retinal analogues. (2011) (35)
- Further advancing the throughput of a multi-beam SEM (2015) (28)
- Seeded watershed cut uncertainty estimators for guided interactive segmentation (2012) (27)
- Odour-evoked [Ca2+] transients in mitral cell dendrites of frog olfactory glomeruli. (2001) (23)
- Oscillatory flow in the cochlea visualized by a magnetic resonance imaging technique. (1993) (22)
- An anatomical substrate of credit assignment in reinforcement learning (2020) (19)
- Learning to Segment Neurons with Non-local Quality Measures (2013) (19)
- Initiation and propagation of calcium-dependent action potentials in a coupled network of olfactory interneurons. (2001) (18)
- Odour‐evoked [Ca2+] transients in mitral cell dendrites of frog olfactory glomeruli (2001) (16)
- Properties of coherence-gated wavefront sensing. (2007) (15)
- Corrigendum: Deep tissue two-photon microscopy (2006) (14)
- Controlling FIB‐SBEM slice thickness by monitoring the transmitted ion beam (2013) (14)
- Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain (2022) (12)
- Low-Dosage Maximum-A-Posteriori Focusing and Stigmation (2013) (12)
- Grand Challenges for Global Brain Sciences (2016) (11)
- Full reconstruction of large lobula plate tangential cells in Drosophila from a 3D EM dataset (2018) (11)
- Pulsing mercury arc lamps for uncaging and fast imaging (1997) (10)
- Simultaneous Recording of Fluctuations of Hair-Bundle Deflection and Intracellular Voltage in Saccular Hair Cells (1989) (10)
- Two-photon Imaging of Neuronal Function in the Neocortex In Vivo (2000) (9)
- Label-free single-instance protein detection in vitrified cells (2020) (8)
- Principles of multiphoton-excitation fluorescence microscopy. (2007) (8)
- Techreview Why Multiphoton Imaging Is More than a Gimmick (1997) (8)
- Two‐photon Microscopy and Imaging (2006) (7)
- Light-efficient, quantum-limited interferometric wavefront estimation by virtual mode sensing. (2006) (5)
- Long duration three-dimensional imaging of calcium waves in zebrafish using multiphoton fluorescence microscopy. (2003) (5)
- Coupling between dendritic spines and shafts in cerebellar Purkinje cells (1997) (4)
- A Fuzzy Algorithm to Trace Stained Neurons in Serial Block-Face Scanning Electron Microscopy Image Series (2009) (3)
- Coherence-gated wavefront sensing using a virtual Shack-Hartmann sensor (2006) (3)
- Author response: EM connectomics reveals axonal target variation in a sequence-generating network (2017) (3)
- Erratum: Connectomic reconstruction of the inner plexiform layer in the mouse retina (Nature (2013) 500 (168-174) DOI:10.1038/nature12346)) (2014) (3)
- Multiphoton microscopy in neuroscience (2002) (3)
- 3D Reconstruction of Neural Circuits from Serial EM Images (2007) (2)
- Functional fluorescent calcium indicator proteins targeted to neurons using adeno−associated viral expression systems (2006) (2)
- Light−evoked calcium signals in ON/OFF direction−selective ganglion cells in the rabbit retina, ARVO #611 (2001) (2)
- Direction-Selective Calcium Signals in Starburst Cell Dendrites (2002) (2)
- In Vivo Calcium Imaging in the Fly Visual System (2005) (2)
- Multi-photon microscopy in neuroscience (2003) (1)
- Author response: Single-protein detection in crowded molecular environments in cryo-EM images (2017) (1)
- Fluid viscosity dominates hair bundle damping in transducer cells of the frog sacculus (1987) (1)
- Connectomic reconstruction of the inner plexiform layer in the mouse retina (2013) (1)
- Multiphoton imaging using a Ti:sapphire regenerative amplifier (2003) (1)
- Multiphoton confocal microscopy (2001) (1)
- Boundary Learning by Optimization with Topological Constraints Supplementary Material (2010) (1)
- Microinterferometry to 1 pm (Invited Paper) (1992) (0)
- Dendritic ‘Hotspots’ of Visually-Evoked Ca2+ Signaling in Starburst Amacrine Cells (2007) (0)
- Adaptive wave-front correction for multi-photon microscopy using coherence-gated wave-front sensing (2006) (0)
- Transgenic mice expressing genetically−encoded calcium indicators under control of a chemically−inducible promoter (2003) (0)
- Imaging tools to reverse engineer the brain (2012) (0)
- biologically useful cross-sections for two photon photolysis Brominated 7-hydroxycoumarin-4-ylmethyls: Photolabile protecting groups with (2006) (0)
- Knossos-A tool to reconstruct neuronal morphology and connectivity from 3 D electron microscopic data (2014) (0)
- Visualizing glutamate receptor(s) trafficking by in vivo two−photon imaging in the somatosensory cortex of transgenic mice (2004) (0)
- New technologies (2004) (0)
- Phase shifts within the auditory hair bundle (1990) (0)
- Two-photon imaging in vivo : transgenic mice, pattern photobleaching, inducible gene expression, and improvements in depth penetration (2002) (0)
- Multi-Photon Microscopy (2019) (0)
- Cochlear fluid motion visualized with magnetic resonance imaging. (1992) (0)
- Corrigendum to “Progress and remaining challenges in high-throughput volume electron microscopy” [Curr Opin Neurobiol 50 (June 2018) 261-267] (2019) (0)
- Retinal Circuit Reconstruction Using Serial Block-Face Scanning Electron Microscopy (2009) (0)
- Tracking glutamate-receptor dynamics in the mouse somatosensory cortex by in vivo two-photon photo-bleaching and imaging (2007) (0)
- The anatomical substrate of precise timing in zebra finch HVC (2016) (0)
- 3D changes in arterial nanostructure during experimental aneurysm growth studied by serial block-face scanning electron microscopy (2006) (0)
- News in Brief (2004) (0)
- A process for preparing submicron droplets of liquid (1998) (0)
- Medical Image Segmentation using an Extended Active Shape Model (2020) (0)
- High-precision automated reconstruction of neurons with flood-filling networks (2018) (0)
- Tunable Ti:Al2O3 oscillator optimized for high-repetition-rate and short pulses (2007) (0)
- Two-photon excitation laser scanning microscopy: applications in neuroscience (1996) (0)
- How do starburst cell dendrites become direction−selective? (2003) (0)
- In vivo imaging of calcium indicator proteins in identified cell types of the cerebellum (2008) (0)
- Targeted patch-clamp recordings from unlabelled neurons in vivo (2006) (0)
- Method and apparatus for measuring wavefronts (2004) (0)
- Connectomic analysis of local HVC circuitry in the zebra finch (2015) (0)
- Faculty Opinions recommendation of Focal spots of size lambda/23 open up far-field fluorescence microscopy at 33 nm axial resolution. (2002) (0)
- Dendritic processing in the direction-selective circuitry of the retina (2007) (0)
- Animals Miniaturization of Two-Photon Microscopy for Imaging in Freely Moving (2014) (0)
- Polarization Effects in Coherence-gated Wave-front Sensing (2005) (0)
- Erratum: Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex (Proceedings of the National Academy of Sciences of the United States of America (December 22, 1998)) (1999) (0)
- Life at 10/sup 10/ W/cm/sup 2/: low-damage microscopy in living specimens using multi-photon microscopy (1998) (0)
- Eyecup Scope – Optophysiological Recordings of Light–Stimulus Evoked Fluorescence Signals in the Retina (2006) (0)
- The Kavli prize winners (2012) (0)
- Two-photon imaging of neuronal populations in the visual cortex of freely-moving animals (2009) (0)
- Laser Scanning Microscope two photons. (1990) (0)
- Multi-Photon Microscopy, High Resolution Imaging Deep in Strongly Scattering Specimens (1997) (0)
- Detection of single action potentials in vitro and in vivo with genetically−encoded Ca2+ sensors (2008) (0)
- InterneuronsPotentials in a Coupled Network of Olfactory Initiation and Propagation of Calcium-Dependent (2015) (0)
- Two-photon excitation scanning microscopy with a compact, mode locked, diode- pumped Cr:LiSAF Laser (1996) (0)
- You can't teach a middle-aged ganglion new tricks (2003) (0)
- New approaches to the measurement of cross-relaxation rates by two-dimensional NMR (1984) (0)
- Life at 101uW/cm2: Low-damage microscopy in living specimens using multi-photon microscopy (1998) (0)
- Biologically Accurate Modeling of Mouse Brain Requires Biologically Accurate Networks (2005) (0)
- In Vivo Dendritic Calcium Imaging in the Fly Visual System (2011) (0)
- Computation of the Directional Asymmetry in Starburst Amacrine Cell Dendrites Involves Voltage–Gated Channels (2006) (0)
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What Schools Are Affiliated With Winfried Denk?
Winfried Denk is affiliated with the following schools:
