Wladimir Wertelecki
Geneticist and pediatrician
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Medical Biology
Wladimir Wertelecki's Degrees
- Masters Epidemiology University of California, Berkeley
Why Is Wladimir Wertelecki Influential?
(Suggest an Edit or Addition)According to Wikipedia, Wladimir Wertelecki is a Pediatrician and Medical Geneticist who in 1974 established one of the first free-standing Departments of Medical Genetics at the new South Alabama University College of Medicine in Mobile, Alabama, U.S.A. Since 1996 and following his retirement as Chairman and Emeritus Professor of Medical Genetics, Pediatrics, and Pathology, he has continued his investigations of developmental anomalies and their prevention as a Project Scientist at the Department of Pediatrics, University of California San Diego. Since 1996, his research has focused mainly on alcohol and ionizing radiation impacts on congenital anomalies. He is the author over 135 scientific reports. In 2000, he established the OMNI-Net Ukraine Programs to investigate reproductive risks posed by exposures to alcohol and Chornobyl ionizing radiation. OMNI-Net Ukraine established a population-based registry for the epidemiological surveillance of congenital anomalies. It qualified to become full member of EUROCAT, a network of over 38 such registries across Europe. OMNI-Net Ukraine is the sole full member of EUROCAT conducting such investigations in regions formerly ruled by the USSR. OMNI-Net Ukraine also implements a variety of collaborative investigations with experts from UCSD, Emory, and other Universities sponsored by the Collaborative Initiative on Fetal Alcohol Spectrum Disorders funded by then National Institute on Alcohol Abuse and Alcoholism . Many components of the OMNI-Net Ukraine programs introduced by Wertelecki were previously implemented in Alabama. He established a regional network of clinics across southern Alabama and West Florida and in 1978 organized the Southern Genetic Group, which expanded into the South-Eastern Regional Genetics Group, enhancing genetic services in six states. Wertelecki also contributed to the efforts by local Native-Americans to gain Federal Recognition as Native-Americans in Alabama. In 1992, he made a presentation to the US Senate regarding the reproductive risks posed by the Chornobyl radiation. Following an initial sponsorship by USAID, he established OMNI-Net programs in Ukraine, a not-for-profit network to provide training and to engage Ukrainian professionals to conduct monitoring of the frequency of birth defects. OMNI-Net teams promptly detected an epidemic of spina bifida and associated malformations collectively known as neural tube defects . The frequency of these malformations and the associated child mortality are persistently the highest in Europe. From the start, OMNI-Net advocates for Ukrainian authorities to introduce folic acid fortification programs, a measure that will significantly reduce the epidemic and related mortality. Flour fortification with folic acid is safe, effective and affordable as shown by implementations adopted by 80 countries. Currently , a legislative initiative to establish an NTD prevention program is under consideration by the Ukrainian National Parliament. OMNI-Net has also documented that thousands of pregnant women continue to accumulate in their bodies through eating, drinking, and inhaling radioactive elements . Whole body counts of incorporated Cs-137 by pregnant women are much higher than in women residing away from Chornobyl radiation impacted regions. OMNI-Net teams seek national and international partners to elucidate the inherent risks of such facts. Although some reports state that Chornobyl radiation is not biologically harmful, OMNI-Net researchers note that such studies did not include pregnant women with known levels of incorporated nuclides. The association of incorporated levels of Cs-137 with prevalence of birth defects remains to be clarified. Another frequent known cause of birth defects in Ukraine is alcohol consumption by pregnant women. Since 2006, OMNI-Net has implemented an international initiative focused on fetal alcohol spectrum disorders. In summary, OMNI-Net is effectively a catalist for joint scientific collaborations of Ukrainian and International investigations.
Wladimir Wertelecki's Published Works
Published Works
- Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22 (1987) (443)
- Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. (1999) (336)
- Epidemiology of congenital diaphragmatic hernia in Europe: a register-based study (2014) (220)
- Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred. (1988) (153)
- Paper 6: EUROCAT member registries: organization and activities. (2011) (123)
- The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: The potential influence of zinc status as an example (2010) (114)
- Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants (2015) (100)
- Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen. (1992) (97)
- Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22. (1990) (89)
- Clinical and chromosomal studies of the 18q- syndrome. (1971) (84)
- Isodicentric Y chromosome: cytogenetic, molecular and clinical studies and review of the literature (1995) (72)
- Malformations in a Chornobyl-Impacted Region (2010) (71)
- Repair of mitochondrial DNA damage induced by bleomycin in human cells. (1995) (69)
- Varied manifestations of a familial lymphoproliferative disorder. (1975) (67)
- Nongonadal neoplasia in Turners syndrome (1970) (64)
- The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. (2015) (63)
- The Clinical Syndrome of Triploidy (1976) (60)
- DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree. (1993) (57)
- Myopathy in Marinesco-Sjogren syndrome. (1987) (49)
- Congenital malformation among offspring of epileptic women. (1973) (48)
- The early treatment of phenylketonuria. (1967) (44)
- DiGeorge syndrome associated with combined immunodeficiency (1972) (44)
- Prevalence and predictors of maternal alcohol consumption in 2 regions of Ukraine. (2014) (43)
- Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure (2016) (42)
- Can prenatal ultrasound detect the effects of in‐utero alcohol exposure? A pilot study (2009) (41)
- PARTIAL DELETION OF CHROMOSOME 18 (1966) (41)
- How valid are the rates of Down syndrome internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research (2010) (39)
- Paternal drinking, intimate relationship quality, and alcohol consumption in pregnant Ukrainian women. (2011) (37)
- Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy (2018) (36)
- Increased Birth Weight in Leukemia (1973) (34)
- Presymptomatic diagnosis for neurofibromatosis 2 with chromosome 22 markers (1993) (34)
- Initial observations of human dermatosparaxis: Ehlers-Danlos syndrome type VIIC. (1992) (33)
- Fetal akinesia and multiple perinatal fractures. (1995) (32)
- Comparative studies of infants with mosaic and complete triploidy: an analysis of 55 cases. (1982) (32)
- Trisomy 22 mosaicism syndrome and Ullrich-Turner stigmata. (1986) (29)
- Dermatoglyphics -- fifty years later. (1979) (29)
- Neuroradiologic findings in Marinesco-Sjögren syndrome. (1998) (29)
- Chronic radiation exposure in the Rivne‐Polissia region of Ukraine: Implications for birth defects (2010) (28)
- Similarity of effects--experimental hyperthermia as a teratogen and maternal febrile illness associated with oromandibular and limb defects. (1985) (27)
- Phenotype–genotype correlations in patients with Marinesco–Sjögren syndrome (2014) (27)
- Prevalence and Mortality in Children with Congenital Diaphragmatic Hernia: A Multi-Country Study. (2020) (27)
- Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development (2019) (26)
- History of the Cerebrohepatorenal Syndrome of Zellweger and Other Peroxisomal Disorders (1988) (24)
- Prenatal detection of de novo duplication of the short arm of chromosome 18 confirmed by fluorescence in situ hybridization (FISH). (1998) (23)
- Nongonadal neoplasia in Turner's syndrome. (1970) (22)
- 45,XO Turner's syndrome and leukaemia. (1970) (22)
- Cytological analyses of a 14p+variant by means of N-banding and combinations of silver staining and chromosome bandings (1979) (21)
- Confirmation of proximal 1q duplication using fluorescence in situ hybridization. (1994) (21)
- The Brain in the 18q‐ Syndrome (1990) (21)
- A method for subclassifying the interdigital patterns: a comparative study of the palmar configurations. (1972) (20)
- High rates of neural tube defects in Ukraine. (2004) (20)
- Dermatoglyphics in Leukemia (1973) (20)
- A novel RSK2 (RPS6KA3) gene mutation associated with abnormal brain MRI findings in a family with Coffin–Lowry syndrome (2006) (20)
- Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine (2014) (19)
- Identification of supernumerary ring chromosome 1 mosaicism using fluorescence in situ hybridization. (1995) (19)
- Neurofibromatosis, skin hemangiomas, and arterial disease. (1982) (18)
- Analysis of Mortality among Neonates and Children with Spina Bifida: An International Registry‐Based Study, 2001‐2012 (2019) (18)
- Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure (2020) (17)
- A rapid method for PCR amplification of DNA directly from cells fixed in Carnoy's fixative. (1995) (17)
- The Use of Cardiac Orienting Responses as an Early and Scalable Biomarker of Alcohol‐Related Neurodevelopmental Impairment (2017) (16)
- Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status (2017) (15)
- Persistent changes in stress-regulatory genes in pregnant woman or a child with prenatal alcohol exposure. (2019) (15)
- Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes. (2016) (15)
- Fertility and the cri du chat syndrome (1993) (14)
- Cantharidin poisoning from ingestion of a "Blister Beetle". (1967) (14)
- Elevated congenital anomaly rates and incorporated cesium-137 in the Polissia region of Ukraine. (2016) (13)
- Non-neural malignancy complicating neurofibromatosis in two relatives. (1985) (13)
- Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2017) (13)
- Birth defects surveillance in Ukraine: a process (2010) (12)
- The Marinesco-Sjögren syndrome described a quarter of a century before Marinesco. (1985) (12)
- Duplication of the short arm of the X chromosome in mother and daugther (1993) (12)
- Angiomas and von Recklinghausen neurofibromatosis. (1988) (11)
- A multi‐country study of prevalence and early childhood mortality among children with omphalocele (2020) (11)
- Chornobyl, radiation, neural tube defects, and microcephaly. (2018) (10)
- FGFR3 gene mutation (Gly380Arg) with achondroplasia and i(21q) Down syndrome: phenotype-genotype correlation. (2000) (10)
- A complex five breakpoint intrachromosomal rearrangement ascertained through two recombinant offspring. (1994) (10)
- Dermatoglyphics in the 18q-Syndrome (1971) (9)
- Prevention of Neural Tube Defects in Europe: A Public Health Failure (2021) (9)
- Chornobyl 30 years later: Radiation, pregnancies, and developmental anomalies in Rivne, Ukraine. (2017) (8)
- 1p microdeletion in sibs with minimal phenotypic manifestations. (1999) (8)
- Abnormal centromere-chromatid apposition (ACCA) and Peters' anomaly. (1985) (8)
- Second-Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders. (2016) (8)
- Dermatoglyphics in leukaemia. (1969) (7)
- DiGeorge syndrome associated with combined immunodeficiency. Dissociation of phytohemagglutinin and mixed leukocyte culture responses. (1972) (7)
- Of dreaming on solid grounds and silent triumphs of one man: a story about Joseph Warkany. (1989) (6)
- Telomeres of higher primates. (1995) (6)
- Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers. (2016) (6)
- Absent d triradius and dotting of the ridges in siblings. (1980) (6)
- Partial trisomy 7p defined by analysis of a complex chromosome rearrangement using a BAC clone panel (2001) (6)
- Molecular characterization of a ring chromosome 16 from a patient with bilateral cataracts. (2002) (6)
- Prevention of birth defects: a task for a world alliance. (1996) (5)
- Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders (2020) (5)
- Genetic services in the United States (1994) (4)
- Relationship of SV40 T‐antigen expression in vitro to disorders of bone marrow function (1980) (4)
- Prevalence and Predictors of Maternal Alcohol Consumption in Two Regions of Ukraine (2014) (4)
- Partner influence as a factor in maternal alcohol consumption and depressive symptoms, and maternal effects on infant neurodevelopmental outcomes. (2021) (4)
- Dermatoglyphic investigations in twins and siblings. (1974) (4)
- Choanal atresia with Down syndrome. (1981) (3)
- Normal and aberrant palmar creases in twins and siblings. (1974) (3)
- The Impact of Micronutrient Supplementation in Alcohol-Exposed Pregnancies on Reaction Time Responses of Preschoolers in Ukraine. (2021) (3)
- Dermatoglyphic investigations: expanding prospects. (1991) (3)
- Translocation 10;18 in a patient with juvenile neuronal ceroid-lipofuscinosis (Batten disease). (1995) (3)
- Gestational age and socioeconomic status as mediators for the impact of prenatal alcohol exposure on development at 6 months (2018) (3)
- Patterns of Prenatal Alcohol Exposure and Alcohol-Related Dysmorphic Features. (2020) (2)
- Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period. (2020) (2)
- Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children (2021) (2)
- Combined system immunodeficiency with Digeorge syndrome and dissociation of PHA-MLC responses. (1973) (2)
- Initial observations of human dermatosparaxis: Ehlers-Danlos type VIIC syndrome (1992) (2)
- [Disorders of reproduction in the diabetic male rat]. (1961) (1)
- Changing trends in dermatoglyphic research. (1982) (1)
- Low Vitamin D status is a common finding in a population of pregnant women enrolled in a nutrition intervention study in the Ukraine (2012) (1)
- A genetic services microcomputer data base. Part I. Design and implementation. (1987) (1)
- Prevalence and mortality among children with anorectal malformation: A multi-country analysis (2022) (1)
- Regional rural genetics program: educational considerations. (1979) (1)
- A teratology information system in vernacular: Closing an information gap (2021) (1)
- Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi‐registry cohort study (2022) (1)
- MICRONUTRIENT SUPPLEMENTS CANMITIGATE THE TERATOGENIC EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON UKRAINIAN INFANTS AT 6 MONTHS (2013) (1)
- Evidence that sister chromatid exchanges and chromatid breaks are two independent events (2004) (1)
- A genetic services microcomputer data base. Part II. Results and trends. (1987) (1)
- Analysis of early neonatal case fatality rate among newborns with congenital hydrocephalus, a 2000–2014 multi‐country registry‐based study (2022) (1)
- Alcohol Consumption and Smoking During Pregnancy Alters Maternal Plasma Fatty Acid Composition: Association with Fetal Alcohol Spectrum Disorders (P11-028-19). (2019) (1)
- Chornobyl radiation—congenital anomalies: A persisting dilemma (2020) (0)
- Rates of Neural Tube Defects in Ukraine Highest in Chornobyl Impacted Regions (2006) (0)
- Antenatal diagnosis of genetic defects. (1976) (0)
- P-43Persistence of elevated incorporated cesium-137 in the Polissia region of Ukraine (2017) (0)
- Dermatoglyphic research and the clinician. (1982) (0)
- Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure (2020) (0)
- Incorporated levels of cesium-137 in pregnant women and prevalence rates of neural tube defects and microcephaly (2018) (0)
- S21 * TOWARD A BETTER UNDERSTANDING OF THE SPECTRUM OF FETAL ALCOHOL SPECTRUM DISORDERS AND THE ROLE OF MATERNAL NUTRITION IN MODIFYING FETAL RISK (2013) (0)
- Clinical genetics: whose business? (1978) (0)
- Pregnant Women with High Levels of 137 Caesium and High Rates of Congenital Anomalies near Chornobyl (2014) (0)
- Yqs in an American family of Scottish descent (2004) (0)
- Adaptation of teratology information systems (2017) (0)
- Wireless Heart Sensor for Capturing Cardiac Orienting Response for Prediction of Neurodevelopmental Delay in Infants (2022) (0)
- Plasma IL‐6 Levels are Elevated During the Third Trimester in Alcohol‐Exposed Women with Children Diagnosed with Fetal Alcohol Spectrum Disorder (FASD) Compared to Alcohol–Exposed Women with Normally Developed Children (2015) (0)
- Prevalence and Mortality among Children with Congenital DiaphragmaticHernia: A Multi-Country Analysis (2021) (0)
- NEUROFIBROMATOSIS II (ACOUSTIC NEUROMA-MENINGIOMA) (1987) (0)
- EPIDEMIC OF NEURAL TUBE DEFECTS IN UKRAINE, OR WHY CHILDREN`S DEATH AND DISABILITIES ARE NOT PREVENTED (2016) (0)
- Josef Warkany's gestation of the teratology society (2020) (0)
- FAMILIAL CARDIOMYOPATHY: A GENERALIZED DISEASE (1977) (0)
- INCLUSION BODY MYOPATHY IN OCULOCRANIOSOMATIC DISEASE (OCSD): 31 (1979) (0)
- Altered nutrient status in alcohol‐exposed pregnant women (2010) (0)
- Subject Index, Vol. 30, 1980 (1980) (0)
- MYOPATHY (SKELETAL AND CARDIAC) AND WHISTLING-FACE SYNDROME (WF) (1987) (0)
- Alcohol-related dysmorphic features as predictors of neurodevelopmental delay in infants and preschool-aged children: Results from a birth cohort in Ukraine. (2022) (0)
- A Multicountry Analysis of Prevalence and Mortality among Neonates and Children with Bladder Exstrophy. (2022) (0)
- Marinesco-Sjögren Syndrome: Neuroradiologic Findings (1999) (0)
- Novel human pathological mutations (2006) (0)
- In Memoriam: H. Warner Kloepfer, 1913–1982 (1983) (0)
- A multi‐program analysis of cleft lip with cleft palate prevalence and mortality using data from 22 International Clearinghouse for Birth Defects Surveillance and Research programs, 1974–2014 (2023) (0)
- 26 Deletion of Chromosome No. 18 (Long Arm). A New Syndrome (1967) (0)
- Altered maternal immune networks are associated with adverse child Check for neurodevelopment: Impact of alcohol consumption during pregnancy (0)
- Dysmorphology in practice (2017) (0)
- MAGNITUDE AND SCOPE OF DYSMORPHOLOGY. 486 (1996) (0)
- PERSISTING PATTERNS OF ELEVATED CONGENITAL MALFORMATIONS IN A CHORNOBYL IMPACTED REGION OF UKRAINE. (Extract from a Monograph on the Subject) (Please contact authors if more information is needed) (2013) (0)
- Chornobyl Radiation – Congenital Anomalies – A Persisting Dilemma (2020) (0)
- Gene symbol: RPS6KA3. (2007) (0)
- Contents, Vol. 30, 1980 (1980) (0)
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