Wolf‐dieter Ludwig
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Why Is Wolf‐dieter Ludwig Influential?
(Suggest an Edit or Addition)Wolf‐dieter Ludwig's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). (1995) (1451)
- A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. (2006) (833)
- Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. (2010) (697)
- Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. (2000) (681)
- Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. (1994) (660)
- Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood (1998) (617)
- Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. (2007) (536)
- Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995 (2000) (524)
- Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000 (2010) (447)
- Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study. (2009) (439)
- Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: A report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90. (1999) (398)
- Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies. (2012) (388)
- Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality. (1985) (363)
- Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): two multicenter studies of the German AML Cooperative Group. (1985) (358)
- Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. (1999) (346)
- Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group. (1999) (345)
- Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report. (2000) (337)
- The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95. (2004) (330)
- Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials (1997) (308)
- Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group. (1995) (301)
- Improved outcome in adult B-cell acute lymphoblastic leukemia. (1996) (293)
- Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. (2005) (287)
- Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. (2006) (273)
- TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (1991) (269)
- Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87. (2005) (267)
- Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. (2011) (261)
- PET-guided treatment in patients with advanced-stage Hodgkin's lymphoma (HD18): final results of an open-label, international, randomised phase 3 trial by the German Hodgkin Study Group (2017) (243)
- Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. (2007) (222)
- Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). (2000) (213)
- Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. (1993) (192)
- Clinical and prognostic relevance of the Kiel classification of non‐Hodgkin lymphomas results of a prospective multicenter study by the Kiel Lymphoma Study Group (1984) (192)
- Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood. (1993) (191)
- Multicentre randomized therapeutic trial for advanced centrocytic lymphoma: Anthracycline does not improve the prognosis (1989) (190)
- Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia. (2006) (190)
- Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87. (1995) (189)
- High Expression Levels of X-Linked Inhibitor of Apoptosis Protein and Survivin Correlate with Poor Overall Survival in Childhood de Novo Acute Myeloid Leukemia (2004) (185)
- Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group studies. (2003) (183)
- Favorable outcome of B-cell acute lymphoblastic leukemia in childhood: a report of three consecutive studies of the BFM group. (1992) (182)
- Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89. (1998) (178)
- Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. (2011) (173)
- Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia (2000) (172)
- Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster. (2000) (171)
- Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo (2000) (170)
- Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group. (1996) (170)
- Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. (1995) (169)
- Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial. (1999) (168)
- The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias. The European Group for the Immunological Classification of Leukemias (EGIL). (1998) (162)
- Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse. (1991) (155)
- Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia. (2000) (153)
- Review of the incidence and clinical relevance of myeloid antigen-positive acute lymphoblastic leukemia. (1991) (153)
- The addition of rituximab to front-line therapy with CHOP (R-CHOP) results in a higher response rate and longer time to treatment failure in patients with lymphoplasmacytic lymphoma: results of a randomized trial of the German Low-Grade Lymphoma Study Group (GLSG) (2009) (151)
- IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol (2010) (144)
- Standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia: Multicentric assessment is feasible (2008) (143)
- Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes (1993) (142)
- Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors. (1992) (141)
- Impact of cranial radiotherapy on central nervous system prophylaxis in children and adolescents with central nervous system-negative stage III or IV lymphoblastic lymphoma. (2006) (136)
- Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. (2006) (134)
- MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. (1998) (131)
- CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia. (1998) (127)
- Prethymic phenotype and genotype of pre-T (CD7+/ER-)-cell leukemia and its clinical significance within adult acute lymphoblastic leukemia. (1989) (126)
- The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function (2010) (126)
- Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: results from ALL-BFM 90 and 95. (2006) (120)
- Acute myeloid leukemias expressing lymphoid-associated antigens: diagnostic incidence and prognostic significance. (1993) (120)
- Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL (2005) (119)
- IKZF1plus Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. (2018) (117)
- Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95. (2005) (115)
- Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26). (1994) (113)
- High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. (2009) (110)
- Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia. (1989) (108)
- XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. (2004) (107)
- Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations (2010) (103)
- High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG (2009) (99)
- Time point-dependent concordance of flow cytometry and real-time quantitative polymerase chain reaction for minimal residual disease detection in childhood acute lymphoblastic leukemia (2012) (98)
- Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia (1996) (96)
- The financing of drug trials by pharmaceutical companies and its consequences. Part 1: a qualitative, systematic review of the literature on possible influences on the findings, protocols, and quality of drug trials. (2010) (95)
- Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients (2000) (94)
- Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia. (2000) (94)
- Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group. (1997) (93)
- CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease (2004) (93)
- Acute myeloid leukemia: analysis of ras gene mutations and clonality defined by polymorphic X-linked loci. (1989) (93)
- High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS. (2007) (91)
- In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-κB activity (2001) (90)
- Prevalence, clinical pattern, and outcome of CNS involvement in childhood and adolescent non-Hodgkin's lymphoma differ by non-Hodgkin's lymphoma subtype: a Berlin-Frankfurt-Munster Group Report. (2007) (88)
- Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow. (2003) (86)
- In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype (2004) (86)
- Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics (1999) (86)
- High-Level Secretion of Tumor Necrosis Factor-alpha Contributes to Hematopoietic Failure in Hairy Cell Leukemia (1989) (86)
- AIEOP‐BFM Consensus Guidelines 2016 for Flow Cytometric Immunophenotyping of Pediatric Acute Lymphoblastic Leukemia (2018) (86)
- Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster groups. (1997) (84)
- Blood dyscrasias induced by psychotropic drugs. (2004) (84)
- The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia (2001) (83)
- Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray (2008) (80)
- Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990–2012 (2015) (77)
- Acute myeloid leukaemia M0: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients (2001) (76)
- Infant acute lymphoblastic leukemia – combined cytogenetic, immunophenotypical and molecular analysis of 77 cases (2002) (75)
- The financing of drug trials by pharmaceutical companies and its consequences: part 2: a qualitative, systematic review of the literature on possible influences on authorship, access to trial data, and trial registration and publication. (2010) (74)
- Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias. (1997) (74)
- Impact of immunophenotyping on management of acute leukemias. (1999) (73)
- Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. (1994) (72)
- Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1 (2000) (71)
- CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review (2004) (70)
- NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia (2013) (69)
- Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: clinical features, treatment, and results in trials NHL-BFM 86 and 90. (2000) (68)
- In vivo expression of survivin and its splice variant survivin‐2B: Impact on clinical outcome in acute myeloid leukemia (2006) (67)
- Expression of the C-kit receptor (CD117) is a feature of almost all subtypes of de novo acute myeloblastic leukemia (AML), including cytogenetically good-risk AML, and lacks prognostic significance. (1999) (67)
- Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. (2005) (66)
- Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia (1998) (66)
- Correlation of protein expression and gene expression in acute leukemia (2003) (66)
- Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping. (2001) (65)
- Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG. (2009) (65)
- Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction (2009) (65)
- Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12 (1998) (64)
- Recombinant human stem cell factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene. (1992) (63)
- Expression and prognostic significance of different mRNA 5′‐end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration (2008) (61)
- Spontaneous remission in adult acute myeloid leukemia in association with systemic bacterial infection—case report and review of the literature (2004) (61)
- Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia (2015) (59)
- Loss of heterozygosity on chromosome 6q14–q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma (2006) (58)
- 2 Immunophenotypic classification of acute lymphoblastic leukaemia (1994) (58)
- Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation (2001) (57)
- Pediatric precursor T lymphoblastic leukemia and lymphoblastic lymphoma: Differences in the common regions with loss of heterozygosity at chromosome 6q and their prognostic impact (2008) (57)
- Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000). (2017) (57)
- The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia. (1995) (53)
- Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans’ cell sarcoma: evidence for hematopoietic plasticity (2010) (53)
- Hematopoietic growth factors in acute myeloid leukemia: supportive and priming effects. (1997) (53)
- Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells. (1996) (53)
- Expression of Late Cell Cycle Genes and an Increased Proliferative Capacity Characterize Very Early Relapse of Childhood Acute Lymphoblastic Leukemia (2006) (53)
- Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84). German Adult ALL Study Group. (1993) (52)
- The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. The German Adult ALL Study Group. (1992) (52)
- dic(9; 20): A new recurrent chromosome abnormality in adult acute lymphoblastic leukemia (1995) (51)
- tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease. (1993) (51)
- High-dose cytosine arabinoside in combination with mitoxantrone for the treatment of refractory acute myeloid and lymphoblastic leukemia. (1987) (51)
- Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells (1997) (51)
- Longterm effects of prolonged maintenance and of very early intensification chemotherapy in AML: data from AMLCG. (1992) (51)
- The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event (1995) (51)
- Terminal deoxynucleotidyl transferase (TdT) expression in acute myeloid leukemia. (1993) (51)
- Improved cure rate by very early intensification combined with prolonged maintenance chemotherapy in patients with acute myeloid leukemia: data from the AML Cooperative Group. (1991) (50)
- Constitutive expression levels of CD95 and Bcl‐2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia (2000) (49)
- Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia (1999) (48)
- Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2 (2001) (47)
- High-dose cytosine arabinoside and mitoxantrone: A highly effective regimen in refractory acute myeloid leukemia (1986) (47)
- Immunophenotypic features of childhood and adult acute lymphoblastic leukemia (ALL): experience of the German Multicentre Trials ALL-BFM and GMALL. (1994) (47)
- Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. (1996) (46)
- Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia (2007) (46)
- Key Treatment Questions in Childhood Acute Lymphoblastic Leukemia: Results in 5 Consecutive Trials Performed by the ALL-BFM Study Group From 1981 to 2000 (2013) (46)
- In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia. (2002) (46)
- Detection and clinical relevance of genetic abnormalities in pediatric acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses. (1993) (45)
- Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11). (1994) (45)
- NONSEGMENTAL VITILIGO: DECREASE OF THE CD45RA+ T‐CELL SUBSET AND EVIDENCE EOR PERIPHERAL T‐CELL ACTIVATION (1992) (45)
- Transforming growth factor-beta 1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product. (1993) (43)
- Clinical significance of cytogenetic studies in childhood acute lymphoblastic leukemia: experience of the BFM trials. (1993) (43)
- Aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients (1995) (42)
- Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. (1998) (41)
- Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis (2002) (41)
- Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment (2005) (41)
- Immunophenotypic and Genotypic Features , Clinical Characteristics , and Treatment Outcome of Adult ProB Acute Lymphoblastic Leukemia : Results of the German Multicenter Trials (1998) (41)
- Front - Line Combined Immuno-Chemotherapy (R-CHOP) Significantly Improves the Time to Treatment Failure and Overall Survival in Elderly Patients with Advanced Stage Follicular Lymphoma - Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG). (2006) (40)
- Acute Myeloid Leukemia with Translocation (8;21). Cytomorphology, Dysplasia and Prognostic Factors in 41 Cases (1996) (40)
- Combined immuno-chemotherapy (R-FCM) results in superior remission rates and overall survival in recurrent follicular and mantle cell lymphoma: Follow-up of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG) (2005) (39)
- Acute myeloid leukemia with translocation (8;21). Cytomorphology, dysplasia and prognostic factors in 41 cases. AML Cooperative Group and ECOG. (1996) (39)
- The Reliability and Specificity of c-kit for the Diagnosis of Acute Myeloid Leukemias and Undifferentiated Leukemias (1998) (39)
- Secondary acute leukaemias with 11q23 rearrangement: clinical, cytogenetic, FISH and FICTION studies (1996) (39)
- High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia (1998) (37)
- Case definition for progressive multifocal leukoencephalopathy following treatment with monoclonal antibodies (2012) (37)
- High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia. (1989) (36)
- Acute myeloid leukemia: treatment over 60. (2002) (35)
- Incidence of thyroid hormone therapy in patients treated with sunitinib or sorafenib: a cohort study. (2012) (35)
- Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH) (1998) (35)
- Mutation analysis of CD95 (APO‐1/Fas) in childhood B‐lineage acute lymphoblastic leukaemia (1998) (34)
- High-dose versus intermediate dose cytosine arabinoside combined with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia: results of an age adjusted randomized comparison. (1993) (34)
- Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts. BFM Relapse Study Group. (1996) (34)
- The prognostic significance of antigen expression in leukaemia. (2003) (34)
- The GSTT1 deletion polymorphism is associated with initial response to glucocorticoids in childhood acute lymphoblastic leukemia (2004) (33)
- Expression of intercellular adhesion molecule 1 (ICAM‐1) in childhood acute lymphoblastic leukaemia: correlation with clinical features and outcome (1997) (33)
- Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells. (1996) (32)
- Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis (2005) (32)
- Normal lymphocytes from leukemic samples as an internal quality control for fluorescence intensity in immunophenotyping of acute leukemias (2006) (32)
- Improved Outcome in High Risk and Very High Risk ALL by Risk Adapted SCT and in Standard Risk ALL by Intensive Chemotherapy in 713 Adult ALL Patients Treated According to the Prospective GMALL Study 07/2003. (2007) (31)
- Fatal spleen rupture during induction chemotherapy with rh GM-CSF priming for acute monocytic leukemia. Clinical case report and in vitro studies. (1993) (31)
- G protein subunit G alpha 16 expression is restricted to progenitor B cells during human B-cell differentiation. (1995) (31)
- High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol (2014) (31)
- Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia (2004) (30)
- Discriminant function analysis as decision support system for the diagnosis of acute leukemia with a minimal four color screening panel and multiparameter flow cytometry immunophenotyping (2007) (29)
- Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL. (2006) (29)
- Functional expression of c-kit by acute myelogenous leukemia blasts is enhanced by tumor necrosis factor-alpha through posttranscriptional mRNA stabilization by a labile protein. (1992) (29)
- CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 (2012) (28)
- New insights into the biology of Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques at the single cell level (1997) (28)
- Morphological and cytochemical findings in 150 cases of T‐lineage acute lymphoblastic leukaemia in adults (1997) (27)
- Immunophenotypic classification of acute lymphoblastic leukaemia. (1994) (27)
- [Concept and interim result of the ALL-BFM 90 therapy study in treatment of acute lymphoblastic leukemia in children and adolescents: the significance of initial therapy response in blood and bone marrow]. (1994) (27)
- Suggestions for improving the design of clinical trials in multiple sclerosis—results of a systematic analysis of completed phase III trials (2019) (26)
- Chronic myelocytic leukemia as a second neoplasia in the course of chronic lymphocytic leukemia. Case report and review of the literature. (1986) (26)
- Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis (2019) (26)
- Immunophenotypic and clinical features of T‐cell receptor γδ+ T‐lineage acute lymphoblastic leukaemia (1998) (25)
- Peripheral blood sCD3− CD4+ T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma (2014) (25)
- Late Relapse of Classical Hodgkin Lymphoma: An Analysis of the German Hodgkin Study Group HD7 to HD12 Trials. (2017) (25)
- Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease (2008) (25)
- Clinical characteristics and treatment outcome of infants with non‐Hodgkin lymphoma (2007) (25)
- Combined Immuno-Chemotherapy (R-CHOP) Results in Significantly Superior Response Rates and Time to Treatment Failure in First Line Treatment of Patients with Lymphomplasmocytoid/ic Immunocytoma (LP-IC) - Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG). (2004) (25)
- Chromosomal abnormalities in adult acute lymphoblastic leukemia: results of the German ALL/AUL Study Group. (1993) (24)
- Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases (2006) (24)
- Acute myelogenous leukaemia in children under 2 years--experiences of the West German AML studies BFM-78, -83 and -87. AML-BFM Study Group. (1992) (24)
- Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome (2012) (24)
- Does the pharmaceutical industry influence guidelines?: two examples from Germany. (2013) (23)
- Lineage Classification of Childhood Acute Lymphoblastic Leukemia according to the EGIL Recommendations: Results of the ALL-BFM 2000 Trial (2013) (23)
- Immunosuppressive effects of recombinant interferon‐α during long‐term treatment of cancer patients (1989) (23)
- Rearrangements of T-cell receptor delta, gamma and beta genes in acute myeloid leukemia coexpressing T-lymphoid features. (1992) (23)
- Cytotoxicity of interleukin 2-induced lymphokine-activated killer (LAK) cells against human leukemia and augmentation of killing by interferons and tumor necrosis factor. (1992) (23)
- In vitro drug resistance profile of Philadelphia positive acute lymphoblastic leukemia is heterogeneous and related to age: a report of the Dutch and German Leukemia Study Groups. (2002) (23)
- Acute myeloid and T‐cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRδ gene rearrangements (1996) (22)
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- Chemotherapy for Adult Acute Myeloid Leukemia: Study Results from the Acute Myeloid Leukemia Cooperative Group and Overview (1993) (0)
- Prognostic Analysis of Pre-Transplant CD26-Positive Lymphocytes and CD26bright/CD45RO-Positive Memory T-Cell Levels in Patients Receiving an Autologous Hematopoietic Progenitor-Cell Transplant. (2007) (0)
- [Characterization of the leukemic cell population in a patient with T-ALL at disease beginning and in recurrence: parallel changes in phenotypic and functional behavior]. (1985) (0)
- [Patient education responsibility, specialty and administration information from the internal medicine viewpoint]. (1997) (0)
- Assessment of Response to Therapy in Primary Myeloid Sarcoma Using Positron Emission Tomography/Computer Tomography Imaging: A Case Report (2008) (0)
- Case Report: A Patient with Haemorrhagic Bleeding, an Acquired Factor VIII Inhibitor and Massive Pulmonary Embolism. (2007) (0)
- [Interview -- drug legislation -- reporting unexpected adverse drug reactions]. (2009) (0)
- [Flow-cytometric immunophenotyping in clinical diagnostics]. (2016) (0)
- Proposal for the classification of relapsed and refractory acute myeloid leukemias as the basis for an age-adjusted randomized comparison of sequentially applied high-dose versus intermediate-dose cytosine arabinoside in combination with mitoxantrone (S-HAM). (1990) (0)
- Monitoring of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia — Preliminary Data from a Prospective Study (1998) (0)
- [Editorial comment on Krege S. et al: off-label use: an unsolved problem]. (2007) (0)
- outcome in childhood AML Intact apoptosis signalling in myeloid leukaemia cells determines treatment (2013) (0)
- Interrelationship of Hairy Cell Leukemia and Phorbol Ester Induced B-Cell “Lymphocytes” as Demonstrated by Monoclonal Antibodies (1985) (0)
- Changes in the Hierarchy of Risk Factors with Older Age in De-Novo Acute Myeloid Leukemia (AML). (2006) (0)
- Aldehyde Dehydrogenase-Positive Hematopoetic Progenitor Cells in Peripheral Blood and Progenitor Cell Apheresis Products: Characterization and Correlation with Kinetics of Engraftment. (2005) (0)
- [Definition of malignant histiocytosis and large cell anaplastic (Ki-1) lymphoma in children]. (1989) (0)
- Feasibility of Multicentric Assessment of MRD in All by Flow-Cytometry: Standardization and Experience of the I-BFM-ALL FCM-MRD Study Group. (2004) (0)
- Significance of Copy Number Alterations for Molecular Treatment Response in Childhood Acute Lymphoblastic Leukemia. (2007) (0)
- CD11b Is a Therapy-Induced Marker for Monitoring Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia. (2007) (0)
- A prospective, randomised study on the use of well-fitting masks for prevention of invasive aspergillosis in high-risk patients (2009) (0)
- leukemia : results in 3184 patients of the AIEOP-BFM ALL 2000 study children and adolescents with B-cell precursor acute lymphoblastic Molecular response to treatment redefines all prognostic factors in (2010) (0)
- Intermediate Dose Cytarabine and Idarubicin for Salvage Therapy of Acute Myeloid Leukemia (1998) (0)
- Karyotypic Abnormalities in Secondary Leukemia of Children (1997) (0)
- Prolonged Remission Duration with Interferon Maintenance After Rituximab-Containing Induction in First-Line Advanced Stage Lymphoplasmacytic Lymphoma – a Retrospective Analysis of the German Low-Grade Lymphoma Study Group (GLSG) (2011) (0)
- treatment outcome in childhood AML Intact apoptosis signaling in myeloid leukemia cells determines (2010) (0)
- Glucocorticoid Therapy Targets Proliferation, Differentiation and Bcl-2 Dependent Survival Signaling in ALL Blasts. (2006) (0)
- PCR as a Diagnostic Tool in ALL: A Comparison Between Cytogenetic and Polymerase Chain Reaction Analysis in Pediatric Patients with Acute Lymphoblastic Leukemia (1994) (0)
- Hematopoietic Growth Factors: Supportive and Priming Effects in AML (1998) (0)
- [Therapy of malignant lymphoma]. (1990) (0)
- The Receptor Tyrosine Kinase ~ 1 8 5 ~ ~ ~ ~ Is Expressed on a Subset of B-Lymphoid Blasts Prom Patients With Acute Lymphoblastic Leukemia and Chronic Myelogenous Leukemia (2002) (0)
- Monitoring of PML-RAR alpha in Patients with Acute Promyelocytic Leukemia (APL) by RT-PCR (1998) (0)
- Network German Low Grade Lymphoma Study Group ( GLSG ) and the European Mantle Cell Lymphoma (2007) (0)
- Abnormal marker expression in acute leukemia (AL) characterized by monoclonal antibodies and flow cytometry. (1987) (0)
- Interleukin-2-Induced Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia: Improvement of Cytotoxicity by Combinations of Lymphokines or Cytokines (1990) (0)
- Prospective Multicenter Study for Patients with Therapy - Related Acute Myeloid Leukemia (AML) Using Intensive Induction and Postremission Therapy. (2006) (0)
- Mitochondrial genome variants in non‐remitting ALL of childhood (2011) (0)
- The Expression of the Adaptor Protein SLP-65 Is Freqently Lost in Childhood B-Lineage Acute Lymphoblastic Leukemia (ALL). (2004) (0)
- GM-CSF in the treatment of acute myeloid leukemia. (1992) (0)
- The Early Treatment Response of the Clinically Challenging Group of Childhood T-ALL without NOTCH1 Mutations Is Signified by a Specific mRNA Gene Profile. (2007) (0)
- cell lymphoma A new prognostic index (MIPI) for patients with advanced-stage mantle (2008) (0)
- High Antileukemic Efficacy and Shortened Neutropenia of Dose-Dense Induction (Sequential-HAM Followed by Pegfilgrastim) in Primary Acute Myeloid Leukemia - Results of a Pilot Study of the German AML-CG. (2007) (0)
- Characterization of the t(7;12) chromosomal translocation in infant AMLs: coexpression of T-cell markers, distinct expression of homeobox genes and inhibition of the non-canonical Nf-kappaB pathway (2009) (0)
- Biologic Determinants for AML Therapy (1998) (0)
- Dose-Dense Induction (Sequential-HAM) in Primary Acute Myeloid Leukemia - A Pilot Study of the AML-CG. (2006) (0)
- Regulation of protooncogenes and cytokine genes in acute lymphoblastic leukemia. (1993) (0)
- Salvage Therapy of Adult ALL (1996) (0)
- Therapeutic and Prognostic Factors in the Management of Acute Myeloid Leukemia (1997) (0)
- [Treatment of adult acute lymphoblastic leukemia]. (1999) (0)
- Trial NHL-BFM 90 Intensification of Therapy: A Report of the Berlin-Frankfurt-Münster Group Improved Treatment Results in Childhood B-Cell Neoplasms With Tailored (2013) (0)
- Altered Expression and Signalling of Bone Morphogenetic Protein Receptor 1A (BMPR-1A) and Enhanced Hematopoietic Progenitor Cell Growth in Long-Term Stromal Culture Assays from Two Patients with a Myeloproliferative Syndrome and Pulmonary Hypertension. (2006) (0)
- Gene Expression Analysis of Leukemic Blasts Persisting at Day 8 of Induction Therapy in Childhood ALL. (2004) (0)
- Effect of Chemotherapy Followed by GM-CSF for Acute Leukemias at Higher Age or After Relapse (1990) (0)
- BALTOMe - ein Langzeitverlauf [BALTOMA - long-term follow-up] (2002) (0)
- High Expression Levels of Iaps Predict Poor Overall Survival in Childhood De Novo Acute Myeloid Leukemia. (2004) (0)
- lymphoblastic leukemia interleukin 7, and early cytoreduction in vivo in childhood T-cell acute apoptotic cell death in context of maturation stage, responsiveness to In vitro susceptibility to dexamethasone- and doxorubicin-induced (2013) (0)
- Outcome of Myelodysplastic Syndrome Treated with Intensive Chemotherapy within the AMLCG99 Trial (2011) (0)
- Site-specific Deletions Involving the ta/-1 and s/l Genes Are Restricted to Cells of the T Cell Receptor cd~ Lineage: T Cell Receptor ~ Gene Deletion Mechanism Affects Multiple Genes By Timo M. Breit,* Ellen J. Mol,* Ingrid L. M. Wolvers-Tettero,* (1993) (0)
- HOX-Gene Expression and Inhibition of the Non-Canonical NF-KappaB Pathway in t(7;12) Leukemias (2008) (0)
- In Vitro Sensitivity to Chemotherapy-Induced Apoptosis in CD2+ve and CD2-ve Childhood T-All (2003) (0)
- Prognostic Value of Dysmyelopoiesis in 128 Patients with De Novo Acute Myeloid Leukemia (1997) (0)
- Biosimilars in Germany: guidance of the Drug Commission of the German Medical Association (2017) (0)
- Involvement of BCL-2 and Bax in the IL-7-lnduced Inhibition of Spontaneous Apoptosis in Childhood T-ALL (2001) (0)
- Intermediate-Risk Acute Lymphoblastic Leukemia (ALL) Patients with and without Relapse Differentially Depend on Survival Signals From Microenvironment (2011) (0)
- Monoclonal antibodies recognizing T-cells (Leu 1) and transferrin receptor (OKT 9) crossreact with malignant B-cells of distinct differentiation stages. (1984) (0)
- All-Trans Retinoic Acid (ATRA) Combined with Double Induction Strategy in Acute Promyelocytic Leukemia (APL). Preliminary Results (1998) (0)
- Treatment of relapsed acute lymphoblastic leukemia (ALL): Improved results in GMALL studies but optimisation is an ongoing challenge (2011) (0)
- [Morphological, immunological and cytogenetic diagnosis in acute leukemias]. (1996) (0)
- Favourable Treatment Outcome in Childhood AML Is Determined by Intact Apoptosis Signalling in Myeloid Leukaemia Cells. (2007) (0)
- MRD-Detection by Multiparametric Flow Cytometry in Childhood Precursor B-Cell All:Predictive Impact of Early Blast Reduction Kinetics in Peripheral Blood (PB) on MRD-Level in Bone Marrow (BM) at Day 33 of the All-BFM2000 Potocol. (2004) (0)
- Arbobacteria – Pathogens Transmittable by Arthropods (2008) (0)
- Biology Oriented Investigation of Treatment Strategies for Acute Myeloid Leukemia (AML): The AMLCG Approach (2003) (0)
- [Thrombotic thrombocytopenic purpura within the scope of disseminated tumor disease]. (1987) (0)
- Heterogeneity of VS2 TCR 6 Gene Rearrangements in Acute Myeloid Leukemia (1994) (0)
- CD95-Mediated Apoptosis in Acute Myeloid Leukemia (AML): Dependence on Maturational Stage and Growth Characteristics in Vitro (1998) (0)
- Induction of lymphokine-activated killer (LAK) cells against human leukemia cells. (1989) (0)
- Cell membrane phenotypes in childhood lymphoid malignancies at relapse defined by monoclonal antibodies (MoAbs) (1986) (0)
- Toxicity and Risk Factors Contributing to Delayed Methotrexate (MTX) Elimination in Adult/Elderly Patients (pts) Treated with High-Dose Methotrexate Therapy (HDMTX), a 2-Year, Single Center Survey. (2006) (0)
- Cytomorphology and Clinical Outcome in 80 Patients with AML M4Eo and Inversion 16 (1997) (0)
- Prognostic Impact of Cytogenetics and Early Response and Efficacy of Sequential High-Dose AraC and Idarubicin (S-HAI) in Patients with Refractory and Relapsed Acute Myeloid Leukemia (AML): Results of a Prospective Study. (2004) (0)
- [Legal aspects of medication prescription]. (2005) (0)
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